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As defined by the World Health Organization, the Eastern Mediterranean Region (EMR), given its special geopolitical situation and internal/external conflicts, faces an increase in illegal activities such as drug production and trafficking, highlighting the need for a comprehensive understanding of the substance use situation. On the basis of a review of published papers between 2015 and 2021 we briefly review substance use in the EMR with special focus on the emerging drugs pertinent to this region, namely tramadol, captagon and khat. [ABSTRACT FROM AUTHOR]

BACKGROUND: Inflammatory states are known to cause an imbalance in the redox status. We aimed to study the possible associations between pro-oxidant-antioxidant balance (PAB) and serum high-sensitive C-reactive protein (hs-CRP) concentrations and traditional cardiovascular disease (CVD) risk factors in an unselected Iranian population and in groups of individuals with specific disease. METHODS: The study was conducted among an unselected population of 758 male subjects. Biochemical markers, including hs-CRP and PAB values, were measured. RESULTS: Serum hs-CRP concentrations were positively associated with serum PAB values (r = 0.260, P <= 0.001). Univariate analysis showed that PAB values were statistically higher in individuals who were obese or smokers compared with non-obese and non-smokers individuals (P < 0.01). While serum hs-CRP concentrations were significantly higher in older subjects, subjects with obesity, diabetes mellitus, metabolic syndrome, central obesity, hypertriglyceridaemia, higher low-density lipoprotein cholesterol concentrations, positive history of CVD and lower physical activity than subjects without these risk factors (P < 0.05). Comparing hs-CRP and PAB values in different CVD risk score subgroups showed a significant incremental rise in both parameters as CVD risk score increased (P < 0.05). Using multiple linear regression analysis we found a strong association between PAB values and hs-CRP concentrations. CONCLUSIONS: This study showed that among Iranian subjects, the inflammatory marker, hs-CRP, was strongly and positively associated with a marker of oxidative stress and also with several traditional risk factors of CVD. Moreover, the impact of traditional cardiovascular risk factors on hs-CRP concentrations and PAB values differed. [ABSTRACT FROM AUTHOR]

Addiction medicine is a dynamic field that encompasses clinical practice and research in the context of societal, economic, and cultural factors at the local, national, regional, and global levels. This field has evolved profoundly during the past decades in terms of scopes and activities with the contribution of addiction medicine scientists and professionals globally. The dynamic nature of drug addiction at the global level has resulted in a crucial need for developing an international collaborative network of addiction societies, treatment programs and experts to monitor emerging national, regional, and global concerns. This protocol paper presents methodological details of running longitudinal surveys at national, regional, and global levels through the Global Expert Network of the International Society of Addiction Medicine (ISAM-GEN). The initial formation of the network with a recruitment phase and a round of snowball sampling provided 354 experts from 78 countries across the globe. In addition, 43 national/regional addiction societies/associations are also included in the database. The surveys will be developed by global experts in addiction medicine on treatment services, service coverage, co-occurring disorders, treatment standards and barriers, emerging addictions and/or dynamic changes in treatment needs worldwide. Survey participants in categories of (1) addiction societies/associations, (2) addiction treatment programs, (3) addiction experts/clinicians and (4) related stakeholders will respond to these global longitudinal surveys. The results will be analyzed and cross-examined with available data and peer-reviewed for publication., Competing Interests: 2.10.6All the investigators involved in designing the surveys, analyzing the data, interpreting the results and publishing the reports will need to report any potential conflict of interest in advance and inform the principal investigators if there is any update in their conflict of interest within 3 months.Dr. MP has consulted for Opiant Therapeutics, Game Day Data, Baria-Tek, the Addiction Policy Forum, AXA, and Idorsia Pharmaceuticals; been involved in a patent application with Yale University and Novartis; received research support from Mohegan Sun Casino, Children and Screens and the Connecticut Council on Problem Gambling; is on the Boards of multiple organizations including the International Society of Addiction Medicine and the Addiction Policy Forum; been a principal investigator on a grant supporting the annual conference of the International Society of Addiction Medicine; participated in surveys, mailings, or telephone consultations related to drug addictions, internet use, impulse-control disorders, and other health topics; consulted for or advised gambling, non-profit and legal entities on issues related to internet use, impulse-control and/addictive disorders; and given academic lectures in grand rounds, continuing medical education events, and other clinical or scientific venues. Dr. AMB has no conflicts of interest with regard to the current work. However unrelated to this project he has received unrestricted educational grants from Schering Plough, Merck Serono, Reckitt Benckiser, CAMURUS and Indivior. The remaining authors declare that the research was conducted in the absence of commercial or financial relationships constituting conflicts of interest., (Copyright © 2024 Ekhtiari, Khojasteh Zonoozi, Rafei, Abolghasemi, Pemstein, Abdelgawad, Achab, Ghafri, Al’Absi, Bisch, Conti, Ambekar, Arunogiri, Bhad, Bilici, Brady, Bunt, Busse, Butner, Danesh, El-Khoury, Omari, Jokūbonis, Jong, Dom, Ebrahimi, Fathi Jouzdani, Ferri, Galea-Singer, Parker, Higuchi, Kathiresan, Khelifa, Kouimtsidis, Krupitsky, Long, Maremmani, McGovern, Mohaddes Ardabili, Rahimi-Movaghar, Rataemane, Sangchooli, Sibeko, Vella, Vista, Zare-Bidoky, Zhao, Javed, Potenza and Baldacchino.)

Background: Metabolic syndrome (MetS) is a cluster of clinical and metabolic features that include central obesity, dyslipidemia, hypertension and impaired glucose tolerance. These features are accompanied by increased oxidative stress and impaired antioxidant defenses. Vitamin E is a major factor in the non-enzymatic antioxidant defenses. The aim of present study was to investigate the association between serum levels of vitamin E and the presence of MetS and its components in a sample population of Mashhad stroke and heart atherosclerotic disorder (MASHAD) cohort study., Methods: This cross-sectional study was carried out in 128 subjects with MetS and 235 subjects without MetS. MetS was defined according to the International-Diabetes-Federation criteria. Serum levels of vitamin E were measured using the HPLC method. Anthropometric and biochemical parameters were measured using standard protocols.  Results. MetS patients had significantly lower serum levels of vitamin E (Vit E), Vit E/Total cholesterol (TC), and Vit E/ (TC+triglyceride(TG)) compared to the control group (P < 0.05).  Vit E/ (TG+TC) was also significantly lower in diabetics or those with elevated levels of high sensitive C-reactive protein (hs-CRP). Additionally, there was a significant association between Vit E/ (TG + Total Cho) and the number of components of the metabolic syndrome (p= 0.02) Conclusions. There is a significant inverse association between indices of Vit E status and the presence of MetS. Moreover, a significantly lower Vit E/ (TC+TG) was observed along with individuals with increasing numbers of components of the MetS.