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1. Genomic analysis of Plasmodium vivax describes patterns of connectivity and putative drivers of adaptation in Ethiopia

Author

Kebede, Alebachew Messele, Sutanto, Edwin, Trimarsanto, Hidayat, Benavente, Ernest Diez, Barnes, Mariana, Pearson, Richard D., Siegel, Sasha V., Erko, Berhanu, Assefa, Ashenafi, Getachew, Sisay, Aseffa, Abraham, Petros, Beyene, Lo, Eugenia, Mohammed, Rezika, Yilma, Daniel, Rumaseb, Angela, Nosten, Francois, Noviyanti, Rintis, Rayner, Julian C., Kwiatkowski, Dominic P., Price, Ric N., Golassa, Lemu, and Auburn, Sarah

Published
2023
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2. Persistent T cell unresponsiveness associated with chronic visceral leishmaniasis in HIV-coinfected patients

Author

de Vrij, Nicky, Pollmann, Julia, Rezende, Antonio M., Ibarra-Meneses, Ana V., Pham, Thao-Thy, Hailemichael, Wasihun, Kassa, Mekibib, Bogale, Tadfe, Melkamu, Roma, Yeshanew, Arega, Mohammed, Rezika, Diro, Ermias, Maes, Ilse, Domagalska, Malgorzata A., Landuyt, Hanne, Vogt, Florian, van Henten, Saskia, Laukens, Kris, Cuypers, Bart, Meysman, Pieter, Beyene, Hailemariam, Sisay, Kasaye, Kibret, Aderajew, Mersha, Dagnew, Ritmeijer, Koert, van Griensven, Johan, and Adriaensen, Wim

Published
2024
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3. A molecular barcode and web-based data analysis tool to identify imported Plasmodium vivax malaria

Author

Trimarsanto, Hidayat, Amato, Roberto, Pearson, Richard D., Sutanto, Edwin, Noviyanti, Rintis, Trianty, Leily, Marfurt, Jutta, Pava, Zuleima, Echeverry, Diego F., Lopera-Mesa, Tatiana M., Montenegro, Lidia M., Tobón-Castaño, Alberto, Grigg, Matthew J., Barber, Bridget, William, Timothy, Anstey, Nicholas M., Getachew, Sisay, Petros, Beyene, Aseffa, Abraham, Assefa, Ashenafi, Rahim, Awab G., Chau, Nguyen H., Hien, Tran T., Alam, Mohammad S., Khan, Wasif A., Ley, Benedikt, Thriemer, Kamala, Wangchuck, Sonam, Hamedi, Yaghoob, Adam, Ishag, Liu, Yaobao, Gao, Qi, Sriprawat, Kanlaya, Ferreira, Marcelo U., Laman, Moses, Barry, Alyssa, Mueller, Ivo, Lacerda, Marcus V. G., Llanos-Cuentas, Alejandro, Krudsood, Srivicha, Lon, Chanthap, Mohammed, Rezika, Yilma, Daniel, Pereira, Dhelio B., Espino, Fe E. J., Chu, Cindy S., Vélez, Iván D., Namaik-larp, Chayadol, Villegas, Maria F., Green, Justin A., Koh, Gavin, Rayner, Julian C., Drury, Eleanor, Gonçalves, Sónia, Simpson, Victoria, Miotto, Olivo, Miles, Alistair, White, Nicholas J., Nosten, Francois, Kwiatkowski, Dominic P., Price, Ric N., and Auburn, Sarah

Published
2022
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4. Prediction of Visceral Leishmaniasis Development in a Highly Exposed HIV Cohort in Ethiopia Based on Leishmania Infection Markers: Results from the Preleish Study

Author

Van Griensven, Johan, primary, Henten, Saskia van, additional, Kibret, Aderajew, additional, Tessema, Mekibib Kassa, additional, Beyene, Hailemariam, additional, Abdellati, Said, additional, Mersha, Dagnew, additional, Sisay, Kasaye, additional, Seyum, Hailemicheal, additional, Eshetie, Hamid, additional, Kassa, Fikadu, additional, Bogale, Tadfe, additional, Melkamu, Roma, additional, Yeshanew, Arega, additional, Smekens, Bart, additional, Burm, Christophe, additional, Landuyt, Hanne, additional, de Hondt, Annelies, additional, Van den Bossche, Dorien, additional, Mohammed, Rezika, additional, Pareyn, Myrthe, additional, Vogt, Florian, additional, Adriaensen, Wim, additional, Ritmeijer, Koert, additional, and Diro, Ermias, additional

Published
2024
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7. Genomic analysis of Plasmodium vivax identifies putative drivers of adaptation and connectivity across diverse districts in Ethiopia

Author

Kebede, Alebachew Messele, primary, Sutanto, Edwin, additional, Trimarsanto, Hidayat, additional, Benavente, Ernest Diez, additional, Barnes, Mariana, additional, Pearson, Richard, additional, Siegel, Sasha, additional, Erko, Berhanu, additional, Assefa, Ashenafi, additional, Getachew, Sisay, additional, Aseffa, Abraham, additional, Petros, Beyene, additional, Lo, Eugenia, additional, Mohammed, Rezika, additional, Yilma, Daniel, additional, Rumaseb, Angela, additional, Nosten, Francois, additional, Noviyanti, Rintis, additional, Rayner, Julian, additional, Kwiatkowski, Dominic, additional, Price, Ric, additional, Golassa, Lemu, additional, and Auburn, Sarah, additional

Published
2023
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8. Population pharmacokinetics of a combination of miltefosine and paromomycin in Eastern African children and adults with visceral leishmaniasis

Author

Verrest, Luka, primary, Roseboom, Ignace C, additional, Wasunna, Monique, additional, Mbui, Jane, additional, Njenga, Simon, additional, Musa, Ahmed M, additional, Olobo, Joseph, additional, Mohammed, Rezika, additional, Ritmeijer, Koert, additional, Chu, Wan-Yu, additional, Huitema, Alwin D R, additional, Solomos, Alexandra, additional, Alves, Fabiana, additional, and Dorlo, Thomas P C, additional

Published
2023
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15. PCR for detection of Leishmania donovani from microscopically negative tissue smears of suspected patients in Gondar, Ethiopia

Author

Melkamu, Roma, primary, Berhane, Nega, additional, Jacobs, Bart K. M., additional, Mohammed, Rezika, additional, Kassa, Mekibib, additional, Yeshanew, Arega, additional, Fikre, Helina, additional, Atnafu, Saba, additional, van Henten, Saskia, additional, van Griensven, Johan, additional, and Pareyn, Myrthe, additional

Published
2023
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16. Persistent T cell unresponsiveness associated with chronic visceral leishmaniasis in HIV-coinfected patients

Author

de Vrij, Nicky, primary, Rezende, Antonio, additional, Pollmann, Julia, additional, Meneses, Ana, additional, Pham, Thao-Thy, additional, Hailemichael, Wasihun, additional, Kassa, Mekebib, additional, Bogale, Tadfe, additional, Melkamu, Roma, additional, Yeshanew, Arega, additional, Mohammed, Rezika, additional, Diro, Ermias, additional, Maes, Ilse, additional, Domagalska, Malgorzata, additional, Landuyt, Hanne, additional, Vogt, Florian, additional, Henten, Saskia van, additional, Laukens, Kris, additional, Cuypers, Bart, additional, Meysman, Pieter, additional, Beyene, Hailemariam, additional, Sisay, Kasaye, additional, Kibret, Aderajew, additional, Mersha, Dagnew, additional, Ritmeijer, Koert, additional, Griensven, Johan Van, additional, and Adriaensen, Wim, additional

Published
2023
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19. Persistent T cell unresponsiveness associated with chronic VL disease in VL-HIV patients

Author

de Vrij, Nicky, Rezende, Antonio Mauro, Pollmann, Julia, Meneses, Ana Victoria Ibarra, Pham, Thao-Thy, Hailemichael, Wasihun, Kassa, Mekebib, Bogale, Tadfe, Melkamu, Roma, Yeshanew, Arega, Mohammed, Rezika, Diro, Ermias, Maes, Ilse, Domagalska, Malgorzata Anna, Landuyt, Hanne, Vogt, Florian, Van Henten, Saskia, Laukens, Kris, Cuypers, Bart, Meysman, Pieter, Beyene, Hailemariam, Sisay, Kasaye, Kibret, Aderajew, Mersha, Dagnew, Ritmeijer, Koert, van Griensven, Johan, and Adriaensen, Wim

Subjects
Visceral leishmaniasis, HIV co-infection, Single-cell TCR, Single-cell RNA, VL-HIV
Abstract

Data for "Persistent T cell unresponsiveness associated with chronic VL disease in VL-HIV patients" Data directory Contains processed single-cell RNA and TCR sequencing of two individuals per group. Patient and grouping information is provided in meta_data.txt Script directories src Contains various scripts used to generate the results and figures in the manuscript. Result directories results Contains the inbetween files for many of the analyses. Contains the Seurat object for the single cell analysis reported in the paper. Also used as output directory for the scripts listed in src, thus containing the figures used in the manuscript.

Published
2023
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20. Paromomycin and Miltefosine Combination as an Alternative to Treat Patients With Visceral Leishmaniasis in Eastern Africa: A Randomized, Controlled, Multicountry Trial

Author

Musa, Ahmed M, primary, Mbui, Jane, additional, Mohammed, Rezika, additional, Olobo, Joseph, additional, Ritmeijer, Koert, additional, Alcoba, Gabriel, additional, Muthoni Ouattara, Gina, additional, Egondi, Thaddaeus, additional, Nakanwagi, Prossy, additional, Omollo, Truphosa, additional, Wasunna, Monique, additional, Verrest, Luka, additional, Dorlo, Thomas P C, additional, Musa Younis, Brima, additional, Nour, Ali, additional, Taha Ahmed Elmukashfi, Elmukashfi, additional, Ismail Omer Haroun, Ahmed, additional, Khalil, Eltahir A G, additional, Njenga, Simon, additional, Fikre, Helina, additional, Mekonnen, Tigist, additional, Mersha, Dagnew, additional, Sisay, Kasaye, additional, Sagaki, Patrick, additional, Alvar, Jorge, additional, Solomos, Alexandra, additional, and Alves, Fabiana, additional

Published
2022
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21. Safety and Effectiveness of Sodium Stibogluconate and Paromomycin Combination for the Treatment of Visceral Leishmaniasis in Eastern Africa: Results from a Pharmacovigilance Programme

Author

Kimutai, Robert, Musa, Ahmed M., Njoroge, Simon, Omollo, Raymond, Alves, Fabiana, Hailu, Asrat, Khalil, Eltahir A. G., Diro, Ermias, Soipei, Peninah, Musa, Brima, Salman, Khalid, Ritmeijer, Koert, Chappuis, Francois, Rashid, Juma, Mohammed, Rezika, Jameneh, Asfaw, Makonnen, Eyasu, Olobo, Joseph, Okello, Lawrence, Sagaki, Patrick, Strub, Nathalie, Ellis, Sally, Alvar, Jorge, Balasegaram, Manica, Alirol, Emilie, and Wasunna, Monique

Published
2017
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24. An open dataset of Plasmodium vivax genome variation in 1,895 worldwide samples

Author

Adam, Ishag, Alam, Mohammad Shafiul, Alemu, Sisay, Amaratunga, Chanaki, Amato, Roberto, Andrianaranjaka, Voahangy, Anstey, Nicholas M, Aseffa, Abraham, Ashley, Elizabeth, Assefa, Ashenafi, Auburn, Sarah, Barber, Bridget E, Barry, Alyssa, Batista Pereira, Dhelio, Cao, Jun, Chau, Nguyen Hoang, Chotivanich, Kesinee, Chu, Cindy, Dondorp, Arjen M, Drury, Eleanor, Echeverry, Diego F, Erko, Berhanu, Espino, Fe, Fairhurst, Rick, Faiz, Abdul, Fernanda Villegas, María, Gao, Qi, Golassa, Lemu, Goncalves, Sonia, Grigg, Matthew J, Hamedi, Yaghoob, Hien, Tran Tinh, Htut, Ye, Johnson, Kimberly J, Karunaweera, Nadira, Khan, Wasif, Krudsood, Srivicha, Kwiatkowski, Dominic P, Lacerda, Marcus, Ley, Benedikt, Lim, Pharath, Liu, Yaobao, Llanos-Cuentas, Alejandro, Lon, Chanthap, Lopera-Mesa, Tatiana, Marfurt, Jutta, Michon, Pascal, Miotto, Olivo, Mohammed, Rezika, Mueller, Ivo, Namaik-Larp, Chayadol, Newton, Paul N, Nguyen, Thuy-Nhien, Nosten, Francois, Noviyanti, Rintis, Pava, Zuleima, Pearson, Richard D, Petros, Beyene, Phyo, Aung P, Price, Ric N, Pukrittayakamee, Sasithon, Rahim, Awab Ghulam, Randrianarivelojosia, Milijaona, Rayner, Julian C, Rumaseb, Angela, Siegel, Sasha V, Simpson, Victoria J, Thriemer, Kamala, Tobon-Castano, Alberto, Trimarsanto, Hidayat, Urbano Ferreira, Marcelo, Vélez, Ivan D, Wangchuk, Sonam, Wellems, Thomas E, White, Nicholas J, William, Timothy, Yasnot, Maria F, Yilma, Daniel, Alam, Mohammad Shafiul [0000-0001-8330-5499], Ashley, Elizabeth [0000-0002-7620-4822], Barber, Bridget E [0000-0003-1066-7960], Batista Pereira, Dhelio [0000-0002-7761-5498], Chu, Cindy [0000-0001-9465-8214], Dondorp, Arjen M [0000-0001-5190-2395], Echeverry, Diego F [0000-0003-0301-4478], Espino, Fe [0000-0003-1690-1711], Faiz, Abdul [0000-0002-3460-7535], Golassa, Lemu [0000-0002-1216-8711], Grigg, Matthew J [0000-0001-9914-8352], Karunaweera, Nadira [0000-0003-3985-1817], Kwiatkowski, Dominic P [0000-0002-5023-0176], Ley, Benedikt [0000-0002-5734-0845], Miotto, Olivo [0000-0001-8060-6771], Nguyen, Thuy-Nhien [0000-0002-4101-5706], Nosten, Francois [0000-0002-7951-0745], Pearson, Richard D [0000-0002-7386-3566], Phyo, Aung P [0000-0002-0383-9624], Price, Ric N [0000-0003-2000-2874], Rayner, Julian C [0000-0002-9835-1014], Urbano Ferreira, Marcelo [0000-0002-5293-9090], Wellems, Thomas E [0000-0003-3899-8454], Yasnot, Maria F [0000-0001-8081-4212], Yilma, Daniel [0000-0001-6058-2696], and Apollo - University of Cambridge Repository

Subjects
parasitic diseases, Genomics, Genomic Epidemiology, Plasmodium vivax, Malaria, Data Resource
Abstract

This report describes the MalariaGEN Pv4 dataset, a new release of curated genome variation data on 1,895 samples of Plasmodium vivax collected at 88 worldwide locations between 2001 and 2017. It includes 1,370 new samples contributed by MalariaGEN and VivaxGEN partner studies in addition to previously published samples from these and other sources. We provide genotype calls at over 4.5 million variable positions including over 3 million single nucleotide polymorphisms (SNPs), as well as short indels and tandem duplications. This enlarged dataset highlights major compartments of parasite population structure, with clear differentiation between Africa, Latin America, Oceania, Western Asia and different parts of Southeast Asia. Each sample has been classified for drug resistance to sulfadoxine, pyrimethamine and mefloquine based on known markers at the dhfr, dhps and mdr1 loci. The prevalence of all of these resistance markers was much higher in Southeast Asia and Oceania than elsewhere. This open resource of analysis-ready genome variation data from the MalariaGEN and VivaxGEN networks is driven by our collective goal to advance research into the complex biology of P. vivax and to accelerate genomic surveillance for malaria control and elimination.

Published
2022

26. An open dataset of Plasmodium vivax genome variation in 1,895 worldwide samples

Author

MalariaGEN, Adam, Ishag, Alam, Mohammad Shafiul, Alemu, Sisay, Amaratunga, Chanaki, Amato, Roberto, Andrianaranjaka, Voahangy, Anstey, Nicholas M, Aseffa, Abraham, Ashley, Elizabeth, Assefa, Ashenafi, Auburn, Sarah, Barber, Bridget E, Barry, Alyssa, Batista Pereira, Dhelio, Cao, Jun, Chau, Nguyen Hoang, Chotivanich, Kesinee, Chu, Cindy, Dondorp, Arjen M, Drury, Eleanor, Echeverry, Diego F, Erko, Berhanu, Espino, Fe, Fairhurst, Rick, Faiz, Abdul, Fernanda Villegas, María, Gao, Qi, Golassa, Lemu, Goncalves, Sonia, Grigg, Matthew J, Hamedi, Yaghoob, Hien, Tran Tinh, Htut, Ye, Johnson, Kimberly J, Karunaweera, Nadira, Khan, Wasif, Krudsood, Srivicha, Kwiatkowski, Dominic P, Lacerda, Marcus, Ley, Benedikt, Lim, Pharath, Liu, Yaobao, Llanos-Cuentas, Alejandro, Lon, Chanthap, Lopera-Mesa, Tatiana, Marfurt, Jutta, Michon, Pascal, Miotto, Olivo, Mohammed, Rezika, Mueller, Ivo, Namaik-Larp, Chayadol, Newton, Paul N, Nguyen, Thuy-Nhien, Nosten, Francois, Noviyanti, Rintis, Pava, Zuleima, Pearson, Richard D, Petros, Beyene, Phyo, Aung P, Price, Ric N, Pukrittayakamee, Sasithon, Rahim, Awab Ghulam, Randrianarivelojosia, Milijaona, Rayner, Julian C, Rumaseb, Angela, Siegel, Sasha V, Simpson, Victoria J, Thriemer, Kamala, Tobon-Castano, Alberto, Trimarsanto, Hidayat, Urbano Ferreira, Marcelo, Vélez, Ivan D, Wangchuk, Sonam, Wellems, Thomas E, White, Nicholas J, William, Timothy, Yasnot, Maria F, Yilma, Daniel, AII - Infectious diseases, Intensive Care Medicine, MalariaGEN, Alam, Mohammad Shafiul [0000-0001-8330-5499], Ashley, Elizabeth [0000-0002-7620-4822], Barber, Bridget E [0000-0003-1066-7960], Batista Pereira, Dhelio [0000-0002-7761-5498], Chu, Cindy [0000-0001-9465-8214], Dondorp, Arjen M [0000-0001-5190-2395], Echeverry, Diego F [0000-0003-0301-4478], Espino, Fe [0000-0003-1690-1711], Faiz, Abdul [0000-0002-3460-7535], Golassa, Lemu [0000-0002-1216-8711], Karunaweera, Nadira [0000-0003-3985-1817], Kwiatkowski, Dominic P [0000-0002-5023-0176], Ley, Benedikt [0000-0002-5734-0845], Miotto, Olivo [0000-0001-8060-6771], Nguyen, Thuy-Nhien [0000-0002-4101-5706], Nosten, Francois [0000-0002-7951-0745], Pearson, Richard D [0000-0002-7386-3566], Phyo, Aung P [0000-0002-0383-9624], Price, Ric N [0000-0003-2000-2874], Rayner, Julian C [0000-0002-9835-1014], Urbano Ferreira, Marcelo [0000-0002-5293-9090], Wellems, Thomas E [0000-0003-3899-8454], Yasnot, Maria F [0000-0001-8081-4212], Yilma, Daniel [0000-0001-6058-2696], and Apollo - University of Cambridge Repository

Subjects
Data resource, parasitic diseases, Medicine (miscellaneous), Genomics, Genomic epidemiology, Plasmodium vivax, General Biochemistry, Genetics and Molecular Biology, Malaria
Abstract

This report describes the MalariaGEN Pv4 dataset, a new release of curated genome variation data on 1,895 samples of Plasmodium vivax collected at 88 worldwide locations between 2001 and 2017. It includes 1,370 new samples contributed by MalariaGEN and VivaxGEN partner studies in addition to previously published samples from these and other sources. We provide genotype calls at over 4.5 million variable positions including over 3 million single nucleotide polymorphisms (SNPs), as well as short indels and tandem duplications. This enlarged dataset highlights major compartments of parasite population structure, with clear differentiation between Africa, Latin America, Oceania, Western Asia and different parts of Southeast Asia. Each sample has been classified for drug resistance to sulfadoxine, pyrimethamine and mefloquine based on known markers at the dhfr, dhps and mdr1 loci. The prevalence of all of these resistance markers was much higher in Southeast Asia and Oceania than elsewhere. This open resource of analysis-ready genome variation data from the MalariaGEN and VivaxGEN networks is driven by our collective goal to advance research into the complex biology of P. vivax and to accelerate genomic surveillance for malaria control and elimination.

Published
2022

27. Paromomycin and Miltefosine Combination as an Alternative to Treat Patients With Visceral Leishmaniasis in Eastern Africa: A Randomized, Controlled, Multicountry Trial.

Author

Musa, Ahmed M, Mbui, Jane, Mohammed, Rezika, Olobo, Joseph, Ritmeijer, Koert, Alcoba, Gabriel, Ouattara, Gina Muthoni, Egondi, Thaddaeus, Nakanwagi, Prossy, Omollo, Truphosa, Wasunna, Monique, Verrest, Luka, Dorlo, Thomas P C, Younis, Brima Musa, Nour, Ali, Elmukashfi, Elmukashfi Taha Ahmed, Haroun, Ahmed Ismail Omer, Khalil, Eltahir A G, Njenga, Simon, and Fikre, Helina

Subjects
ANTIPROTOZOAL agents, RESEARCH, LEISHMANIASIS, COMBINATION drug therapy, CONFIDENCE intervals, MULTIVARIATE analysis, NEOMYCIN, TREATMENT effectiveness, RANDOMIZED controlled trials, MILTEFOSINE, DESCRIPTIVE statistics, DATA analysis software, LOGISTIC regression analysis, PHARMACODYNAMICS
Abstract

Background This study aimed to determine whether paromomycin plus miltefosine (PM/MF) is noninferior to sodium stibogluconate plus paromomycin (SSG/PM) for treatment of primary visceral leishmaniasis in eastern Africa. Methods An open-label, phase 3, randomized, controlled trial was conducted in adult and pediatric patients at 7 sites in eastern Africa. Patients were randomly assigned to either 20 mg/kg paromomycin plus allometric dose of miltefosine (14 days), or 20 mg/kg sodium stibogluconate plus 15 mg/kg paromomycin (17 days). The primary endpoint was definitive cure after 6 months. Results Of 439 randomized patients, 424 completed the trial. Definitive cure at 6 months was 91.2% (155 of 170) and 91.8% (156 of 170) in the PM/MF and SSG/PM arms in primary efficacy modified intention-to-treat analysis (difference, 0.6%; 97.5% confidence interval [CI], −6.2 to 7.4), narrowly missing the noninferiority margin of 7%. In the per-protocol analysis, efficacy was 92% (149 of 162) and 91.7% (155 of 169) in the PM/MF and SSG/PM arms (difference, −0.3%; 97.5% CI, –7.0 to 6.5), demonstrating noninferiority. Treatments were well tolerated. Four of 18 serious adverse events were study drug–related, and 1 death was SSG-related. Allometric dosing ensured similar MF exposure in children (<12 years) and adults. Conclusions PM/MF and SSG/PM efficacies were similar, and adverse drug reactions were as expected given the drugs safety profiles. With 1 less injection each day, reduced treatment duration, and no risk of SSG-associated life-threatening cardiotoxicity, PM/MF is a more patient-friendly alternative for children and adults with primary visceral leishmaniasis in eastern Africa. Clinical Trials Registration NCT03129646. [ABSTRACT FROM AUTHOR]

Published
2023
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28. Aetiologies of acute undifferentiated febrile illness at the emergency ward of the University of Gondar Hospital, Ethiopia

Author

Akelew, Yibeltal, primary, Pareyn, Myrthe, additional, Lemma, Mulualem, additional, Negash, Markos, additional, Bewket, Gezahegn, additional, Derbew, Agegnehu, additional, Belay, Gizeaddis, additional, Pollmann, Julia, additional, Adriaensen, Wim, additional, Peeters, Marjan, additional, Ombelet, Sien, additional, Adane, Aynishet, additional, Mohammed, Rezika, additional, Griensven, Johan, additional, and Cnops, Lieselotte, additional

Published
2022
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29. Evaluation of the CL Detect Rapid Test in Ethiopian patients suspected for Cutaneous Leishmaniasis

Author

van Henten, Saskia, primary, Fikre, Helina, additional, Melkamu, Roma, additional, Dessie, Dilargachew, additional, Mekonnen, Tigist, additional, Kassa, Mekibib, additional, Bogale, Tadfe, additional, Mohammed, Rezika, additional, Cnops, Lieselotte, additional, Vogt, Florian, additional, Pareyn, Myrthe, additional, and van Griensven, Johan, additional

Published
2022
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34. Miltefosine for the treatment of cutaneous leishmaniasis—A pilot study from Ethiopia

Author

van Henten, Saskia, primary, Tesfaye, Annisa Befekadu, additional, Abdela, Seid Getahun, additional, Tilahun, Feleke, additional, Fikre, Helina, additional, Buyze, Jozefien, additional, Kassa, Mekibib, additional, Cnops, Lieselotte, additional, Pareyn, Myrthe, additional, Mohammed, Rezika, additional, Vogt, Florian, additional, Diro, Ermias, additional, and van Griensven, Johan, additional

Published
2021
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39. Single-Dose Tafenoquine to Prevent Relapse ofPlasmodium vivaxMalaria

Author

Lacerda, Marcus V.G., primary, Llanos-Cuentas, Alejandro, additional, Krudsood, Srivicha, additional, Lon, Chanthap, additional, Saunders, David L., additional, Mohammed, Rezika, additional, Yilma, Daniel, additional, Batista Pereira, Dhelio, additional, Espino, Fe E.J., additional, Mia, Reginaldo Z., additional, Chuquiyauri, Raul, additional, Val, Fernando, additional, Casapía, Martín, additional, Monteiro, Wuelton M., additional, Brito, Marcelo A.M., additional, Costa, Mônica R.F., additional, Buathong, Nillawan, additional, Noedl, Harald, additional, Diro, Ermias, additional, Getie, Sisay, additional, Wubie, Kalehiwot M., additional, Abdissa, Alemseged, additional, Zeynudin, Ahmed, additional, Abebe, Cherinet, additional, Tada, Mauro S., additional, Brand, Françoise, additional, Beck, Hans-Peter, additional, Angus, Brian, additional, Duparc, Stephan, additional, Kleim, Jörg-Peter, additional, Kellam, Lynda M., additional, Rousell, Victoria M., additional, Jones, Siôn W., additional, Hardaker, Elizabeth, additional, Mohamed, Khadeeja, additional, Clover, Donna D., additional, Fletcher, Kim, additional, Breton, John J., additional, Ugwuegbulam, Cletus O., additional, Green, Justin A., additional, and Koh, Gavin C.K.W., additional

Published
2019
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40. Antigen Detection in Urine for Noninvasive Diagnosis and Treatment Monitoring of Visceral Leishmaniasis in Human Immunodeficiency Virus Coinfected Patients: An Exploratory Analysis from Ethiopia

Author

Vogt, Florian, primary, Mengesha, Bewketu, additional, Asmamaw, Helen, additional, Mekonnen, Tigist, additional, Fikre, Helina, additional, Takele, Yegnasew, additional, Adem, Emebet, additional, Mohammed, Rezika, additional, Ritmeijer, Koert, additional, Adriaensen, Wim, additional, Melsew, Yayehirad, additional, van Griensven, Johan, additional, and Diro, Ermias, additional

Published
2018
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41. Leishmania Antigenuria to Predict Initial Treatment Failure and Relapse in Visceral Leishmaniasis/HIV Coinfected Patients: An Exploratory Study Nested Within a Clinical Trial in Ethiopia

Author

van Griensven, Johan, primary, Mengesha, Bewketu, additional, Mekonnen, Tigist, additional, Fikre, Helina, additional, Takele, Yegnasew, additional, Adem, Emebet, additional, Mohammed, Rezika, additional, Ritmeijer, Koert, additional, Vogt, Florian, additional, Adriaensen, Wim, additional, and Diro, Ermias, additional

Published
2018
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43. Long-term Clinical Outcomes in Visceral Leishmaniasis/Human Immunodeficiency Virus–Coinfected Patients During and After Pentamidine Secondary Prophylaxis in Ethiopia: A Single-Arm Clinical Trial

Author

Diro, Ermias, primary, Ritmeijer, Koert, additional, Boelaert, Marleen, additional, Alves, Fabiana, additional, Mohammed, Rezika, additional, Abongomera, Charles, additional, Ravinetto, Raffaella, additional, De Crop, Maaike, additional, Fikre, Helina, additional, Adera, Cherinet, additional, van Loen, Harry, additional, Tsoumanis, Achilleas, additional, Adriaensen, Wim, additional, Hailu, Asrat, additional, and Griensven, Johan van, additional

Published
2017
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44. Development and external validation of a clinical prognostic score for death in visceral leishmaniasis patients in a high HIV co-infection burden area in Ethiopia

Author

Abongomera, Charles, primary, Ritmeijer, Koert, additional, Vogt, Florian, additional, Buyze, Jozefien, additional, Mekonnen, Zelalem, additional, Admassu, Henok, additional, Colebunders, Robert, additional, Mohammed, Rezika, additional, Lynen, Lutgarde, additional, Diro, Ermias, additional, and van Griensven, Johan, additional

Published
2017
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45. Use of Pentamidine As Secondary Prophylaxis to Prevent Visceral Leishmaniasis Relapse in HIV Infected Patients, the First Twelve Months of a Prospective Cohort Study

Author

Diro, Ermias, primary, Ritmeijer, Koert, additional, Boelaert, Marleen, additional, Alves, Fabiana, additional, Mohammed, Rezika, additional, Abongomera, Charles, additional, Ravinetto, Raffaella, additional, De Crop, Maaike, additional, Fikre, Helina, additional, Adera, Cherinet, additional, Colebunders, Robert, additional, van Loen, Harry, additional, Menten, Joris, additional, Lynen, Lutgarde, additional, Hailu, Asrat, additional, and van Griensven, Johan, additional

Published
2015
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46. Shigella Bacteremia in a Patient with Visceral Leishmaniasis

Author

Endris, Mengistu, Mohammed, Rezika, Takele, Yegnasew, Woldeyohannes, Desalegn, Tiruneh, Moges, and Diro, Ermias

Subjects
Article Subject
Abstract

Bacteremia due to Shigella is rare. A 26-year-old HIV-negative male presented with a persistent high-grade fever of two months duration to the Leishmaniasis Research and Treatment Center of University of Gondar Hospital. He was anorexic and had lost significant weight (from 76 to 57 kg in 4 months, BMI = 17.2 kg/m2). He also complained of headache, chills, and rigor. In the last one year, he was experiencing a few episodes of acute bloody diarrhea, the last episode being two months ago. Microscopy from splenic aspiration showed Leishman-Donovan bodies with parasite load of +3. The blood culture showed Shigella species, but the stool was culture negative. The isolate was sensitive to most tested antibiotic discs, sulfamethoxazole, ceftriaxone, gentamicin, tetracycline, and norfloxacilin, except ampicillin. Therefore, requesting blood culture for identifying unexpected type of organisms causing infections in patients with underlying diseases like visceral leishmaniasis should be encouraged.

Published
2013
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47. Long-term Clinical Outcomes in Visceral Leishmaniasis/ Human Immunodeficiency Virus-Coinfected Patients During and After Pentamidine Secondary Prophylaxis in Ethiopia: A Single-Arm Clinical Trial.

Author

Diro, Ermias, Ritmeijer, Koert, Boelaert, Marleen, Alves, Fabiana, Mohammed, Rezika, Abongomera, Charles, Ravinetto, Raffaella, Crop, Maaike De, Fikre, Helina, and Adera, Cherinet

Subjects
PENTAMIDINE, CONFIDENCE intervals, HIV infections, LEISHMANIASIS, RISK assessment, PROPORTIONAL hazards models, KAPLAN-Meier estimator, MIXED infections, SYMPTOMS, THERAPEUTICS
Abstract

Background. We have conducted a single-arm trial evaluating monthly pentamidine secondary prophylaxis (PSP) to prevent visceral leishmaniasis (VL) relapse in Ethiopian human immunodeficiency virus-infected patients. Outcomes at 12 months of PSP have been previously reported, supporting PSP effectiveness and safety. However, remaining relapse-free after PSP discontinuation is vital. We now report outcomes and associated factors for a period of up to 2.5 years after initiating PSP, including 1-year follow-up after PSP discontinuation. Methods. The trial had 3 phases: (1) 12 months of PSP; (2) a 6-month PSP extension period if CD4 count was ≤200 cells/μL at month 12; and (3) 12-month follow-up after stopping PSP. The probability of relapse and risk factors were calculated using Kaplan- Meier methods and Cox regression analysis. Results. For the 74 patients included, final study outcomes were as follows: 39 (53%) relapse-free, 20 (27%) relapsed, 5 (7%) deaths, 10 (14%) lost to follow-up. The 2-year risk of relapse was 36.9% (95% confidence interval, 23.4%-55.0%) and was highest for those with a history of VL relapse and low baseline CD4 count. Forty-five patients were relapse-free and in follow-up at month 12 of PSP. This included 28 patients with month 12 CD4 counts >200 cells/µL, remaining relapse-free after PSP discontinuation. Among the 17 with month 12 CD4 count <200 cells/µL, 1 relapsed and 3 were lost during the PSP extension period. During 1-year post-PSP follow-up, 2 patients relapsed and 1 was lost to follow-up. No PSP-related serious adverse events were reported during the PSP-extension/post-PSP follow-up period. Conclusions. It seems safe to discontinue PSP at month 12 CD4 counts of >200 cells/µL. The management of those failing to reach this level remains to be defined. Clinical Trials Registration. NCT01360762. [ABSTRACT FROM AUTHOR]

Published
2018
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48. Impact of the Use of a Rapid Diagnostic Test for Visceral Leishmaniasis on Clinical Practice in Ethiopia: A Retrospective Study

Author

Diro, Ermias, primary, Lynen, Lutgarde, additional, Assefa, Mahlet, additional, Takele, Yegnasew, additional, Mengesha, Bewketu, additional, Adem, Emebet, additional, Mohammed, Rezika, additional, Kimutai, Robert, additional, Hailu, Asrat, additional, Boelaert, Marleen, additional, and van Griensven, Johan, additional

Published
2015
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