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The use of gamification to enhance learning in education has been well documented. However, little is known about whether gamification can impact supply chain management knowledge and behaviors among healthcare professionals. In this study, we tested the effectiveness of a simulation app (ShipShape) designed and developed to gamify the fundamental concepts of supply chain management. We field tested the effectiveness of the app to impact knowledge gain and supply chain practice by asking healthcare professionals to use the app in their day-to-day operations. We collected longitudinal data spanning the period before and after the introduction of the app. The analysis and results of different types of data collected provide support for the positive impact of the app on both supply chain knowledge and practice among healthcare professionals.