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Melochia corchorifolia is a well-known perennial herb and has been used in traditional medicine for the treatment of a wide number of diseases. However, the phytochemical investigation in the different organs of the M. corchorifolia was poorly understood. In the present study, the organ-specific metabolomic profiling of leaves, stems, and vegetable extract of M. corchorifolia was determined, and their potential antibiofilm activity with wound healing properties was evaluated. The UPLC-ESI-Q-TOF-MS E analysis showed 59 compounds in the leaf, stem, and vegetable extracts of M. corchorifolia. The crystal violet staining assay clearly showed that the extracts of M. corchorifolia have excellent antibiofilm activity against Proteus mirabilis and Salmonella typhi. The extracts of M. corchorifolia also caused the architecture of the bacterial biofilm by inhibiting the adherence to polystyrene and auto-aggregation and subsequently inhibiting the growth and colonization of the biofilm-forming bacteria P. mirabilis and S. typhi. The extracts of M. corchorifolia accelerate the wound healing process in BALB/c mice by completely closing the wound on the 20th day of treatment. Together, the phytochemicals present in the leaf, stem, and vegetable extracts of M. corchorifolia are responsible for potent antibiofilm and wound healing properties and could be used as an excellent remedy for treating chronic wounds and their associated infectious disease., (© 2024. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.)