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Background: The first mass vaccination program for COVID-19 in India started on January 16, 2021. Initially, Covaxin and Covishield were used. Later, the Government of India has approved the usage of Corbevax, a Hyderabad-based biological E SARS-CoV-2 (COVID-19) vaccine among 12- to 14-year age group from March 16, 2022. Corbevax vaccination was started in our hospital setting on March 19, 2022, for 12- to 14-year age group. Monitoring safety of any vaccine is of importance in a real-world setting. Limited study has been performed till date on side effects of Corbevax vaccine. Therefore, this study has been planned to assess the side effects after Corbevax vaccination among 12- to 14-year age group in a tertiary care hospital setting in Meerut district. To assess the side effects after Corbevax vaccination among 12- to 14-year age group in a tertiary care hospital setting in Meerut district. Tertiary care hospital setting and cross-sectional study design. Methods and Material: A cross-sectional study was conducted among 270 study participants. Sample size was calculated assuming 50% prevalence of side effects after vaccination. Study subjects were selected by using simple random sampling among the beneficiaries of a tertiary care center. Data were collected using a pretested semistructured questionnaire. Proportions, Chi-square test. Results: Of all the participants, 41.48% had developed side-effects with pain at site of injection being the most commonly reported symptom (64.29%), and about half among those affected had resolved spontaneously. Conclusions: The vaccine causes only mild symptoms and is safe for use in children.

Background: Adductor canal block (ACB) is an emerging technique for postoperative analgesia following knee surgery. ACB technique is relatively easy and is performed under ultrasound guidance. Aims: This study aimed to compare the efficacy of fentanyl and magnesium sulfate as adjuvants with 0.5% ropivacaine in ACB for patients undergoing knee surgeries. Adverse events if any were also noted. Materials and Methods: The study was conducted on 100 patients aged 40–80 years posted for knee surgeries. They were divided into two groups of 50 each: Group ropivacaine with fentanyl (RF) and Group ropivacaine with magnesium (RM). Group RF received 30 mL of 0.5% ropivacaine with 50 μg of fentanyl. Group RM received 30 mL of 0.5% ropivacaine with 125 mg of magnesium sulfate. Both the groups were compared on the basis of time for the first rescue analgesia given after the block. The results were analyzed using the SPSS software. Results: The mean time of the first rescue analgesia was 8.40 ± 0.85 h in Group RF and 10.63 ± 1.10 h in Group RM, which was higher and statistically significant (P = 0.002). Rescue analgesia was given more frequently in Group RF (5.77±3.84) compared to group RM (3.20±1.27) and this was statistically significant (P = 0.000). There were no significant adverse events noted in both the groups. Conclusion: Both the adjuvants, when added to ropivacaine, prolong the duration of blockade and reduce the requirement of rescue analgesia without causing significant adverse effects, but magnesium sulfate has an extra edge over fentanyl in terms of longer duration of postoperative analgesia.

The intermolecular interactions of amino acids (glycine, L–alanine, and L–valine) in aqueous solutions of an ionic liquid, 1–butyl–3–methylimidazolium methylsulfate [Bmim][MeSO4] as a function of temperature have been investigated by combination of volumetric and acoustic methods. The density, ρ, and speed of sound, u, of glycine, L–alanine and L–valine in aqueous 1–buytl–3–methylimidazolium methylsulfate solutions have been measured in the temperature interval T = (288.15, 298.15, and 308.15) K and atmospheric pressure. These data have been used to calculate apparent molar volume (V∅), and apparent molar adiabatic compressibility (K∅,s) of these mixtures at different temperatures. Later, the standard partial molar volume (V∅0), standard partial molar volumes of transfer (ΔV∅0), standard partial molar adiabatic compressibility (K∅,s0), and standard partial molar adiabatic compressibility (ΔK∅,s0) of transfer have been determined for these amino acid solutions from density and speed of sound data. Also, hydration number (nH) and various group contribution have been calculated. Finally the results have been interpreted in terms of solute - solvent interactions that exist among the currently investigated systems.

This case report discusses the abuse of methamphetamine in North East India.