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Abstract Antibiotic resistance in bacterial pathogen infections is a growing global issue that occurs due to their adaptation to changing environmental conditions. Therefore, producing an efficient vaccine as an alternative approach can improve the immune system, eradicate related pathogens, and overcome this growing problem. Streptococcus agalactiae belongs to group B Streptococcus (GBS). Colonization of GBS during pregnancy is a significant risk factor for infants and young children. S. agalactiae infected population exhibits resistance to beta-lactams, including penicillin and the second-line antibiotics erythromycin and clindamycin. On the other hand, there are currently no commercial vaccines against this pathogen. Vaccination of pregnant women is a highly effective method to protect newborns and infants from S. agalactiae infection, and it has been identified as an urgent demand by the World Health Organization. This study employed various immunoinformatic tools to develop an effective vaccine that could trigger both humoral and cell-mediated immunity and prevent disease. For this purpose, three conserved antigenic proteins of the main pathogenic strains of S. agalactiae were utilized to predict CTL, HTL, and B-cell epitopes for producing an mRNA vaccine against different strains of S. agalactiae. The selected epitopes were fused using proper linkers. The Resuscitation promoting factor E (RpfE) sequence was incorporated in the designed vaccine construct as an adjuvant to boost its immune response. Different physicochemical characteristics of the final designed vaccine, modeling of the three-dimensional structure, molecular docking, molecular dynamics simulation, and immunological response simulation were screened following vaccine administration in an in vivo model. Computational immune simulation data identified that IgG1, IgM, INF γ, IL-2, T helper, and B-cell populations increased significantly after vaccination. These findings suggested that the vaccine candidate may provide good protection against S. agalactiae infection. However, experimental and animal model studies are required for additional validation and implementation in human vaccination programs.

In this study, a sophisticated two-step methodology is proposed that incorporates the Kolarik and Hashin–Hansen models to precisely evaluate the effects of the interphase on the Young's modulus of nanodiamond (ND)-filled composites. Initially, the ND particles and their surrounding interphase were modeled as a core-shell structure, and the modulus of this structure was calculated. Subsequently, the core-shell particles were considered as a dispersed phase within a polymer matrix, leading to determination of the Young's modulus of the nanocomposite. The results obtained using the proposed method agreed well the experimental data of various nanocomposite samples. Furthermore, a robust correlation was indicated between the interphase properties and nanocomposite modulus. Notably, an interphase characterized by a thickness of 10 nm, modulus of 50 GPa, and a filler volume fraction of 0.02 increased the nanocomposite modulus to more than 3 GPa, assuming a matrix modulus of 1 GPa. Additionally, the findings revealed that ND particles with radii smaller than 4 nm had a remarkable influence on the nanocomposite modulus, whereas a high ND modulus had a minimal effect.

Abstract Background Community-acquired pneumonia (CAP) is a major global health threat for children, causing numerous hospitalizations and deaths. CAP is a leading cause of mortality in children under five and results in millions of hospital admissions each year. Identifying reliable prognostic markers is crucial. Mean platelet volume (MPV) and red blood cell distribution width coefficient of variation (RDW_CV) are accessible and cost-effective options for prognosis assessment. This study investigates MPV and RDW_CV as prognostic markers in children with CAP. Methods This cross-sectional study included 150 children aged 1–15 years diagnosed with CAP upon initial examination and admitted to the hospital. CAP diagnosis was based on clinical symptoms, physical examination, and/or radiographic findings, with hospitalization criteria set for CAP in children. CAP severity was assessed using the Clinical Respiratory Score, categorizing patients into mild, moderate, and severe groups. MPV and RDW_CV were compared among these groups. Results Among the patients, 71 (47.3%) were girls, and 79 (52.7%) were boys. The average hospitalization duration was 6.24 ± 3.82 days, with a median of 5 days. Disease severity distribution was 58 (38.7%) mild, 54 (36.0%) moderate, and 38 (25.3%) severe. Both RDW_CV and MPV were higher in severe cases and in children hospitalized for more than 10 days (P

Abstract Objective The purpose of this study is a new update on the resistance profile, Macrolide–Lincosamide–Streptogramin B resistance mechanisms and biofilm formation in the Staphylococcus aureus isolated from health care workers (HCWs) nasal carriage at a children’s teaching hospital in Babol (Northern Iran). Results A total of 143 non-repetitive nasal swab samples were collected from volunteers, where 53.8% (n; 77/143) were HCWs, 33.6% (n; 48/143) medical students, and 12.6% (n; 18/143) resident students. The prevalence of nasal carriers of S. aureus was 22.4% (n; 32/143), among them, 40.6% (n; 13/32) were identified as methicillin-resistant Staphylococcus aureus (MRSA( carriers. Antimicrobial susceptibility testing showed that erythromycin (68.8%, n; 22/32) and ciprofloxacin (15.6%, n; 5/32) had the highest and lowest resistance rate, respectively. The frequency of resistance genes in the strains was as follows; ermC (n; 17/32, 53.1%), ermA (n; 11/32, 34.4%), ermB (n; 6/32, 18.7%), ereA (n; 3/32, 9.4%). Moreover, 50.0% (n; 16/32), 28.1% (n; 9/32) and 21.8% (n; 7/32) of isolates were strongly, weakly and moderately biofilm producer, respectively. Macrolides-lincosamides-streptogramins B (MLSB) antibiotic resistance among S. aureus isolates from HCWs nasal carriage have found significant prevalence rates throughout the globe. It is crucial to remember that the development of biofilms and MLS B antibiotic resistance are both dynamic processes.

A catalyst based on zero-valent iron nanoparticles (nZVI) supported by zeolite Y (zeolite Y-nZVI) was synthesized to improve the performance of the heterogeneous electro-Fenton-like process for treating a toxic pesticide wastewater with pH of 6. Central Composite Design (CCD) under Response Surface Methodology (RSM) was applied to design the experiments and find the optimal parameters including time, current intensity, hydrogen peroxide volume (or concentration) and the synthesized catalyst dosage. The results showed that the chemical oxygen demand (COD) removal under the optimal conditions (time of 125 min, current intensity of 272 mA, hydrogen peroxide volume (or concentration) of 0.19 ml (8.102 × 10−3 M), and zeolite Y-nZVI catalyst dosage of 1.78 g) was at 83.69 % for treating a wastewater with pH of 6 although this increased to 91.26 % at pH of 3 under the Fenton reactions. In fact, the synthesized catalyst could properly treat wastewater in a pH close to neutral one. Since electro-Fenton is as efficient technique for treating the hazardous pollutants such as pesticide, it can successfully be used by their manufacturing factories. Since it properly works in the acidic pHs, it is not as applied technique for most of industries. Therefore, catalytic electro-Fenton process can be performed in (or near) a neutral pH. Since electro-Fenton is basically associated with iron, a catalyst based on it (such as Fe°) was chosen and supported on an abundant and suitable material such as zeolite. The synthesized catalyst was initially synthesized and characterized, and then successfully applied in the electro-Fenton process to treat a real pesticide containing wastewater obtained from industry.

Background: Pott’s Puffy tumor (PPT) is a complicated frontal sinusitis that is also described as frontal bone osteomyelitis and a localized sub periosteal abscess. Early diagnosis and immediate active treatment are necessary to prevent severe neurologic sequelae. Case Presentation: Here, we report on a case of Pott’s puffy tumor in a previously healthy 13-year-old girl with a worsening headache and swelling of the frontal bone accompanied by vomiting and fever. Magnetic resonance imaging revealed osteomyelitis of the frontal bone. A foreign body was discovered and removed via endoscopy which was then followed by 6 weeks of parenteral and enteral antibiotic therapy, resulting in resolution of all symptoms. Conclusion: A complete history in terms of trauma and insect bite or foreign body in the nose is paramount for a correct diagnosis, and performing a full examination of ear, nose and throat (ENT) to rule out a foreign body is advised.

Plasmid-mediated quinolone resistance (PMQR) in extended-spectrum β-lactamase (ESBL)-producing Klebsiella pneumoniae (K. pneumoniae) contributes to treatment failures, extended hospital stays, and increased mortality percentages. We aimed to determine the prevalence of PMQR genes in ESBL-producing K. pneumoniae isolates from clinical samples in Babol, North of Iran region. This is the first study in this region to investigate this specific association. A total of 95 K. pneumoniae isolates were obtained from hospitalized patients with various clinical infections during March 2022 to February 2023. Disk diffusion and Combination disk method were performed to identification of antimicrobial resistance profiles and ESBL-producing strains. The presence of ESBL and PMQR genes among K. pneumoniae isolates was assessed using polymerase chain reaction (PCR) method. Of the isolates, 68 (71.57 %) were considered as ESBL-producers. The blaTEM, blaSHV and blaCTX-M genes were detected in 74.73 %, 57.89 %, and 41.05 % of K. pneumoniae isolates, respectively. Among the PMQR encoding genes, the highest and lowest frequency was associated to qepA (67.3 %) and qnrA (4.2 %), respectively. The frequency of qnrA, qnrB, qnrS, acc (6′)-Ib-cr, qepA, oqxA, and oqxB genes in 26 MDR-Kp isolates was 11.53 % (n; 3), 69.23 % (n; 18), 65.38 % (n; 17), 73.07 % (n; 19), 80.76 % (n; 21), 84.61 % (n; 22), and 76.92 % (n; 20), respectively. Our result revealed of the 68 ESBL gene-positive isolates, 60 (88.23 %) were positive for the PMQR gene. The co-occurrence of these genes within resistant isolates suggests potential linkage on mobile genetic elements such as plasmids. These findings highlight the significant burden of PMQR determinants in ESBL-producing K. pneumoniae and underscore the urgent need for effective control measures. Implementing robust antimicrobial stewardship programs and strengthening drug-resistance surveillance and control protocols are crucial to prevent the spread of resistant isolates.

In an era of advancing technology, nurses find themselves at the forefront of protecting patient information. Safeguarding patient information is a critical concern in healthcare settings due to the potential adverse effects that can result from breaches or mishandling of this data. This invasion of privacy can have profound emotional, social, and financial repercussions for patients. In this article, possible and effective approaches were provided under Evolving cybersecurity threats, balancing access and privacy, human error and insider threats, education and training, interoperability and data sharing headings. Patient information security is a complex and ever-evolving challenge for nursing professionals. Nurses must remain vigilant, well-informed, and proactive in implementing cybersecurity best practices.

The presence of microplastics in tidal sediments is a growing ecotoxicological concern for sea and benthic health. This investigation was designed to record and characterize the vertical prevalence of microplastics (MPs) in intertidal sediments of the Persian Gulf (around Bushehr city, Iran). Sediments of three depths (0-10 cm, 10-20 cm, and 20-30 cm) were sampled during low tide in six sites along the coastal zone of Bushehr, Iran. MP particles were found in all evaluated areas and sediment depths. The average abundance of MPs in all of the sediment samples was 117.96 ± 97.75 particles kg−1 dry sediment. No differences were found in the MPs number among the sites. The most dominant microplastics in surface sediments were 2-5 mm in size. In all areas, fibers and fragments were more abundant. Particles in higher depths (0-10 cm) were often colorless (white, and transparent). Raman spectroscopy indicated the presence of polystyrene, polyethylene, polyvinyl chloride, polyethylene terephthalate, and polypropylene in the samples. Further research is required to evaluate the possible interaction between MPs and layers of sediments. Waste management and proper wastewater disposal are critical to control MPs pollution in intertidal ecosystems around coastal cities.

Foam stability tests were performed using sodium dodecyl sulfate (SDS) surfactant and SiO2 nanoparticles as foaming system at different asphaltene concentrations, and the half-life of CO2 foam was measured. The mechanism of foam stability reduction in the presence of asphaltene was analyzed by scanning electron microscope (SEM), UV adsorption spectrophotometric concentration measurement and Zeta potential measurement. When the mass ratio of synthetic oil to foam-formation suspension was 1:9 and the asphaltene mass fraction increased from 0 to 15%, the half-life of SDS-stabilized foams decreased from 751 s to 239 s, and the half-life of SDS/silica-stabilized foams decreased from 912 s to 298 s. When the mass ratio of synthetic oil to foam-formation suspension was 2:8 and the asphaltene mass fraction increased from 0 to 15%, the half-life of SDS-stabilized foams decreased from 526 s to 171 s, and the half-life of SDS/silica-stabilized foams decreased from 660 s to 205 s. In addition, due to asphaltene-SDS/silica interaction in the aqueous phase, the absolute value of Zeta potential decreases, and the surface charges of particles reduce, leading to the reduction of repulsive forces between two interfaces of thin liquid film, which in turn, damages the foam stability.

Abstract Background The aim of the present study was to compare the epidemiological patterns of severe acute respiratory syndrome coronavirus 2 (SARS-CoV2) infections, hospitalizations, deaths, and duration of hospitalization during the fourth, fifth and sixth epidemic waves of coronavirus disease 2019 (COVID-19) in Iran. Methods A multicenter retrospective observational study was conducted on hospitalized patients in four hospitals in the Babol district of northern Iran. The study periods were during the fourth, fifth, and sixth waves of the epidemic in Iran, (March 2021 to March 2022). A total of 13,312 patients with suspected COVID-19 were included. Patient demographics, medical history, length of hospital stay, and clinical outcomes were obtained from the hospital information system. Data on the cycle threshold (Ct) and SARS-CoV2 variant were collected for SARS-CoV2-positive cases. Results The highest number of hospitalized patients was reported during the fifth (Delta) wave (5231; 39.3%), while the lowest number of hospitalized patients was reported during the sixth (Omicron) wave (2143; 16.1%). In total, 6459 (48.5%) out of 13,312 hospitalized patients with suspected COVID-19 had a positive rRT-PCR result. The fifth (Delta) wave had the highest number of SARS-CoV2 rRT-PCR-positive hospitalized patients (3573, 55.3%), while the sixth (Omicron) wave had the lowest number (835, 12.9%). Moreover, 238 (3.7%) patients with laboratory-confirmed COVID-19 died. The hospital mortality rate was 6.8% in the fourth (Alpha) wave, which reduced to 2.7 and 3.5% in the fifth (Delta) and sixth (Omicron) waves, respectively (p

Purpose: This study examines the relationship between financial development, corruption, and entrepreneurship in a sample of 21 emerging economies from 2008 to 2020. Methodology: Utilizing the Generalized Method of Moments (GMM) econometric approach, we explore the interactive dynamics between these variables. Results: Our findings indicate that higher levels of corruption are associated with increased entrepreneurial activity in these economies. This can be attributed to the prevalence of corrupt practices, such as bribery, which serve as a means for entrepreneurs to overcome barriers and initiate businesses. Conversely, while financial development has a positive influence on entrepreneurship, its impact is not statistically significant. However, when considering a combined effect of financial development and corruption, a positive net impact is observed. This suggests that corruption can facilitate access to financial resources for entrepreneurs in these emerging economies. These findings support the notion of the “grease the wheels effect”. Conclusion: This study provides valuable insights into the complex interplay between financial accessibility, corruption, and entrepreneurship in emerging economies, informing policymakers and stakeholders on strategies to foster entrepreneurship and drive sustainable economic growth.

Enterprises employ information systems to execute their day-to-day business operations. To enhance their competitive edge through efficient process management, organizations implement business policies. This paper aims to propose a method that combines two approaches: evidence-based policymaking and process mining, to facilitate process reengineering. Many evidence-based approaches based on process mining techniques have been conducted to evaluate process performance through measurements. However, these approaches mainly concentrate on individual process instances, whereas assessments of Business Process Redesign (BPR) primarily employ comprehensive performance measurements, such as overall process performance. This study suggests a method for analyzing process execution time, including Cycle time, Lead time, and Activity time, for evidence-based policymaking in information systems using process mining. Several Key Performance Indicators (KPIs) have been defined for the evidence-based management of business processes to pinpoint process bottlenecks. The results demonstrate that evidence from process mining can be utilized to validate the effectiveness of existing policies.

This study illustrated the impact of Saponins in electrospun nanofibers on nerve regeneration and compared them with Tween 80, which is commonly used as a synthetic surfactant. The study explores the effect of Saponins, natural emulsifiers known for their effectiveness in forming and stabilizing emulsions. Surfactant choice is crucial due to its effects on fluid stability, influenced by parameters like polymer concentration, homogenization rate, and surfactant type/amount. This study explored PCL as the core and PVA as the shell.Core/shell scaffolds displayed favorable wettability (contact angle: 67.0° ± 1.3) and improved mechanical properties (wet state tensile strength: PVA 1.1 ± 0.2 MPa, PVA/PCL-Saponin 2.0 ± 0.5 MPa). The MTT viability assay demonstrated higher viability of PC12 cells on Saponin-containing nanofibers (85.0 % ± 0.1) compared to Tween 80 (69.0 % ± 0.1) after 24 h. Subcutaneous implantation in rats showed no significant inflammation after one week. Eventually, in the animal model, the conduit containing Saponin was more effective than Tween 80 in repairing the rat's sciatic nerve within six weeks, as evidenced by NF-200 counts and histological studies. Overall, the study indicates that PVA/PCL-Saponin nanofibers, without requiring Saponin surfactant removal, show high quality and effectiveness for tissue engineering and medical purposes.

Fusarium head blight (FHB) is a devastating fungal disease of hexaploid wheat (Triticum aestivum). Several genetic loci were previously identified that control FHB resistance in wheat, including Fhb1. Fhb7, a major QTL conferring resistance to FHB, controlling for mycotoxin deoxynivalenol (DON) production, has been introgressed into soft red winter wheat (SRWW). As an exotic QTL, Fhb7 is associated with linkage drag, affecting agronomic and end-use quality performance. This study outlines a breeding strategy for introducing and pyramiding Fhb7 into SRWW breeding populations that already possessed Fhb1 and harbored some additional disease-resistance genes. In addition to the Fhb1-Fhb7 pyramiding, we developed gene-based markers for both genes and examined them on 57 SRWW breeding lines. Our data showed that 15 out of 57 breeding lines possessed both Fhb1 and Fhb7 resistant alleles. Two years of phenotypic data from the inoculated and misted irrigation field showed that the combination of Fhb1-Fhb7 lowers mycotoxin DON accumulation in kernels, which provides protection for end-users and the milling industry. The Fhb gene-pyramided lines, with the additional regionally important disease resistance genes, produced in this breeding pipeline showed reasonable agronomic traits and can be used in crossing programs for the widespread introgression in elite wheat cultivars.

This research presents a comprehensive study on the application of hydroxypropyl cellulose/zinc oxide nanocomposite (HPC/ZnO NC) as an effective consolidant in leather conservation. The critical focus is to prevent photooxidative degradation, a significant challenge in preserving historical leather artifacts. The nanocomposite was evaluated for its protective capabilities against environmental stressors like UV radiation and moisture, mechanical robustness, and potential to stabilize acid-damaged leather. The uniform dispersion of ZnO NPs in the HPC matrix was revealed as crucial for improving leather properties, which was confirmed through SEM imaging. The HPC/ZnO NC coating effectively prevented UV-induced microcracks, surface degradation and collagen denaturation. It also demonstrated enhanced mechanical resistance, inhibiting the reduction in leather’s maximum tolerable force and increasing the elongation index, even after aging. Additionally, it exhibited improved water-repellent properties and increased the pH of the leather, offering potential benefits for the treatment of acid-degraded leathers. Overall, the findings affirm that the application of HPC/ZnO NC significantly augments the physical and mechanical properties of leather, providing enhanced resistance to environmental degradation.

Abstract Enhancing the mechanical and thermal properties of Silicone rubber (SR)/SEBS blends using various compatibilizers opens the opportunity for such new blends to meet the market desire. For this purpose, blends with a 1:1 ratio of SR and SEBS are prepared with different amounts of EVA or SEBS-MA copolymers as compatibilizer. Mechanical properties of the blend are enhanced by adding EVA and SEBS-MA. Addition of 6 phr EVA profoundly improves the tensile strength from 7.70 to 10.06 MPa. Thermogravimetric analysis reveals that the presence of compatibilizer can improve the thermal stability of the blend, especially its initial degradation temperature (T5%). T5% of the blend increases from 376 to 390 °C when comprising 6 phr SEBS-MA. Morphology of the blends is investigated using SEM and AFM. Results of the relaxation modulus curves obtained by rubber process analyzer (RPA) demonstrate that the amount of relaxation in the uncured blends is higher than the cured ones. A comparison of the relaxation of the blends indicates that the relaxation modulus of the SEBS-MA compatibilized blends is enhanced more than other blends after curing. Further investigations indicate that the compatibilized blends exhibit higher tear energy and lower compression set.

Background and purpose: Urinary tract anomalies are responsible for urinary tract infection (UTI) in more than 30% of children. The present study was carried out to determine the prevalence of urinary tract anomalies in children with pyelonephritis referred to Amirkola Children Hospital during 2010-2020. Materials and methods: In this cross-sectional study, all children with UTI admitted to Amirkola Children Hospital during 2010-2020 were enrolled. The inclusion criteria were children aged between 2 months and 18 years, positive signs and symptoms of UTI, and positive urine culture with reliable sampling. Children with a positive history of surgery on the urinary tract were excluded. Imaging studies included ultrasonography, DMSA, DTPA, VCUG, RNC, and IVP for the diagnosis of anomalies in the urinary tract. Results: Among 381 children with pyelonephritis, the mean age was 37.1+41.3 months, and 337 (88.5%) children were girls. One hundred forty-nine (39.1%) children had urinary anomalies. The most anomalies were VUR, ureterovesical junction obstruction, Ureterocele, and ureteral duplication in 112(75.16%), 11(7.38%), 9(6.04%), and 8(5.36%) of children, respectively. A significant difference was observed between age and anomaly prevalence (P=0.04), but there was no significant difference between sex and prevalence of anomaly (P=0.3). Conclusion: The results of the study showed that about 39% of children with UTI had urological anomalies, the most common cause of which was VUR, and other urological anomalies (about a quarter) such as ureterovesical junction obstruction, Ureterocele. In addition to vesicoureteral reflux, paying attention to other urological anomalies in these children is recommended

Background and Aim: Alzheimer’s is a chronic disease that causes cognitive disabilities, thinking, personality changes and disruptions in daily activities. Due to these disorders, patients need long-term care. Most care for Alzheimer’s patients is done at home by family members, which makes home caregivers mentally, physically, emotionally, socially and financially vulnerable. Health personnel have a key role to play in providing information and guidance and helping the family control these conditions. The purpose of this study was to examines the level of knowledge and attitude of health workers and determines the related factors. Materials and Methods: This research is a cross-sectional study to evaluate the level of knowledge and attitude of health workers about Alzheimer’s disease and its related factors. All 260 health workers of Gorgan and Kordkuy districts were studied by census method to assess their knowledge and attitude about Alzheimer’s disease and its related factors. ANOVA and T-tests were used to determine the relationship between the independent variables and the dependent variable. Variables whose significant level of correlation with response variable was less than 0.2 in bivariate analysis were entered into the regression model and finally multiple linear regression was used to determine the factors related to level of knowledge and attitude. Results: The mean level of knowledge was 46.73% (95% CI, 45.46 to 48.16) and the mean level of attitude was 55.61% (95% CI, 54.63 to 56.74). The results show that those with a history of previous education, a history of caring for Alzheimer’s patients, a higher level of work experience in the health care system, and having a female gender and be married have higher levels of knowledge and those with a history of previous education and Sistani descent had a higher attitude. Conclusion: In general, the mean level of knowledge was 46.73(0-100) and the mean level of attitude was 55.61(0-100). Factors such as: gender, work history in the health system, history of participating in educational workshops, history of caring for sick patients, and marital status were related to the level of knowledge and factors such as ethnicity and history of participating in the training workshop were related to the level of attitude of the health care providers.

Background and purpose: This study examines the ultrasound in diagnosing abnormal urological conditions in AmirKola Children's Hospital. Materials and methods: Children with febrile acute pyelonephritis meeting specific inclusion criteria were enrolled in the study, encompassing those aged 1 month to 18 years during the period 2011-2021. Ultrasound was conducted to diagnose structural abnormalities of the urinary system. Results: Indicate that enlarged kidneys above the normal size (29%) and hydronephrosis (27%) were the most common abnormalities. Among the findings, boys exhibited a higher prevalence of abnormalities compared to girls. Ultrasound was effective in diagnosing anomalies in children below two years (41%) and above two years (47%). E.coli (83%) was the most common microorganism across all age groups and genders. Conclusion: The study suggests that ultrasound, as a non-invasive, accessible, and cost-effective method, is recommended for diagnosing urological abnormalities in children with febrile acute pyelonephritis.

In the present work, a 3D finite element model was created using the commercial ABAQUS software to analyze the selective laser melting process of AlSi10Mg powder in a bidirectional multi-track, multi-layer configuration. The focus of this investigation was to examine distribution of temperature, melt pool geometry, thermal history, and the temperature change rate. To improve the accuracy of the results, the enhanced thermal conductivity was utilized to incorporate the Marangoni convection effect. The results revealed that, in the initial track, the maximum temperature and dimensions of the melt pool increased, ultimately reaching a plateau as the deposited path extended. However, using a bidirectional scan strategy, the maximum temperature at the second track reached its peak and then stabilized. While the maximum heating and cooling rates in the first track showed a nearly identical trend, both parameters decreased at the beginning of the second track and then began to rise again. It can be attributed to the overlapping of the molten zone between the first and second tracks. With an increase in the number of tracks, the maximum temperature, melt pool width, and depth increased until they reached a steady state, with specific values of 2093 K, 258 μm, and 150 μm, respectively. Introducing more layers initially caused an increase in the maximum temperature and dimensions of the melt pool, which eventually reached a steady-state condition. Finally, temperature distribution of the steady-state simulated melt pool was found to match with thermal behavior and eutectic Si features of the experimental sample.

Background and purpose: The aim of the study was to determine the relationship between electrolyte disorders and disease severity in children with COVID-19 infection referred to Amirkola Children's Hospital. Materials and methods: We performed the cross-sectional study on children aged 1 month to 18 years with COVID-19 infection referred to Amirkola pediatrics hospital, Babol, Iran from March 2018 to July 2018. The level of serum of potassium, sodium, calcium, and fasting blood sugar were measured at the beginning of hospitalization in all study children. Severity of COVID-19 infection was evaluated with Pediatric Early Warning Score (PEWS). Data were analyzed using Chi-Square, ANOVA, and logistic regression tests. P-values of less than 0.05 were considered significant. Results: Out of 160 children referred to the hospital during the study, 122 were selected. The most common electrolyte disorders were hyponatremia (42.6%) and hypocalcaemia (16.4%). No significant relationship was found between calcium (P=0.30) and potassium (P=0.12) disorders and severity of COVID-19 infection. There was a significant relationship between the sodium disorder and severity of COVID-19 infection (P

Abstract Nickel–aluminum bronzes (NAB) are vital alloys, known for biofouling resistance, crucial for marine and shipbuilding industries. This study examined corrosion performance of NAB samples fabricated by wire arc additive manufacturing (WAAM) in as-built and heat-treated conditions. Microstructural analysis revealed the WAAM-NAB parts primarily consisted of the α-phase (copper) and three types of κ-phases: κII (spherical Fe3Al), κIII (Ni–Al in lamellar shape) within the interdendritic areas, and iron-rich κIV particles dispersed throughout the matrix. In contrast, casting-produced NAB showed the formation of a rosette-like κI phase as well. Corrosion behavior comparisons between the two NAB fabrication methods were also assessed. The microstructural characterizations revealed a rise in the size of the κIV particles after heat-treated at 350 °C for 2 h (HT1). Heat treatment at 550 °C for 4 h (HT2) resulted in a needle-like κV, coarsening of κII, partial spheroidization of κIII, and reduced κIV precipitation. When heat-treated to 675 °C for 6 h (HT3), κII and κV were coarsened, κIII was completely spheroidized, and κIV precipitation was significantly reduced. These microstructural features in HT2 and HT3 conditions steeply decreased their corrosion resistance compared to the WAAM as-built part. The as-built WAAM sample showed superior corrosion resistance in chloride solution, attributed to fewer κ-intermetallic phases and a finer microstructure. The κ-phases, irrespective of morphology, act as the cathodic areas versus the α-dendritic matrix, fostering microgalvanic cell formation. Consequently, precipitation of all cathodic κ-phases draws a higher galvanic current of the anodic α-phase, meaning a lower corrosion resistance.

Abstract The growing use of wireless technologies in power systems has raised concerns about cybersecurity, particularly regarding GPS spoofing attacks (GSAs). These attacks manipulate GPS data, leading to modifications in the phase angle of phasor measurement units (PMUs). In this paper, a Deep‐learning GPS‐Spoofing Counteraction (DLGSC) algorithm is proposed, utilizing PMU data for GSA detection and PMU data correction. The algorithm incorporates a recurrent neural network (RNN) and a set of long short‐term memory (LSTM) units separately, for signal correction after attack detection. Unlike existing methods that struggle with simultaneous attacks or they are static methods, DLGSC tackles these challenges by leveraging deep learning techniques. By selecting appropriate features for GSA detection, DLGSC achieves accurate results. The algorithm is evaluated on standard IEEE 14‐bus and IEEE 39‐bus power systems, and its performance is compared to statistical, dynamic, and Deep Learning (DL) methods in the literature. Additionally, an experimental setup is designed to validate the algorithm in a laboratory environment. Results demonstrate the easy‐implementable DLGSC algorithm's satisfactory real‐time performance in various scenarios, such as load variations and noise, achieving over 98% accuracy. Notably, DLGSC is cable of detecting multiple GSAs on different PMUs.

Reza Valizadeh1, Hamidreza Mohammadi2, Ali Ghaffarian Bahraman3, Mohsen Mohammadi4, Javad Ghasemian Yadegari5 1 Pharmacy Student, Student Research Committee, Lorestan University of Medical Sciences, Khorramabad, Iran 2 Assistant Professor, Department of Toxicology, Faculty of Pharmacy, Razi Herbal Medicines Research Center, Lorestan University of Medical Sciences, Khorramabad, Iran 3 Assistant Professor, Occupational Environment Research Center, Rafsanjan University of Medical Sciences, Rafsanjan, Iran 4 Associate Professor, Department of Pharmaceutical Biotechnology, Faculty of Pharmacy, Hepatitis Research Center, Lorestan University of Medical Sciences, Khoramabad, Iran 5 Assistant Professor, Department of Pharmacognosy, Faculty of Pharmacy, Lorestan University of Medical Sciences, Khorramabad, Iran In the article published in volume 33, issue 221, 2024, the image number 1 was published incorrectly and has been corrected.

The current research aims to explore the effects of entrepreneurship on economic growth in a sample of 35 emerging countries from 2006 to 2020, considering that these effects might not follow a simple linear and predictable pattern. In other words, this study strives not only to assess the positive or negative impact of entrepreneurship on economic growth but also to analyze the nonlinear and more intricate variations of these effects. This research utilizes entrepreneurship density data provided by the World Bank and employs the innovative dynamic threshold panel approach proposed by Seo and Shin (2016) and Seo et al. (2019) to investigate the threshold effect of entrepreneurship on economic growth. The results of this study indicate that achieving a meaningful and positive impact of entrepreneurship on economic growth in developing countries requires a minimum density of approximately 3.25 entrepreneurs per 1000 people. This finding suggests that policymakers should create an environment that not only promotes entrepreneurship but also strengthens it to reach this crucial threshold for economic growth. Additionally, when variables such as per capita income, trade openness, financial development, and income from natural resources exceed a certain threshold level, the significant effect of entrepreneurship on economic growth becomes evident. These findings are of great importance for policymakers, particularly in developing countries interested in enhancing entrepreneurship and economic growth, as they can utilize this information to design effective policies and initiatives. The identification of the threshold level of entrepreneurial activity and the consideration of contextual factors provides policymakers with practical insights for policy and initiative design.

IntroductionSocial dissatisfaction in Iran, particularly over the past decade, has been widespread and profound, as confirmed by national surveys. A review of the last four decades reveals the emergence of social discontent and political unrest in various manifestations and at different times. In certain instances, such as in 2009, the protests have posed a threat to the survival and stability of the Islamic Republic of Iran. Indeed, an analysis of the frequency and duration of social protests demonstrates the growth and prevalence of social dissatisfaction within Iranian society.Social dissatisfaction can manifest itself through apathy and non-participation, as seen in the decline in political participation during the Islamic Council and presidential elections in in the recent decade, particularly in 2019 and 2021. A review of relevant research shows a lack of deep insight and comprehensive understanding of social dissatisfaction as a multi-faceted issue in Iran, which can be a major obstacle to insightful policymaking for successful and cost-effective management of social dissatisfaction.The present research aimed to analyze and elucidate the underlying factors that contribute to social dissatisfaction, and subsequently develop strategies for effectively managing and mitigating the issue within Iranian society. The objective can ultimately enhance the efficiency of the decision-making process and policymaking in order to effectively address social dissatisfaction and protests. Accordingly, the main research questions are: What are the causal factors underlying social dissatisfaction in the Islamic Republic of Iran? and what are the potential solutions to solve the issue?Materials and MethodsThe present research employed a mixed methods research design. The documentary analysis method was utilized to examine and analyze various perspectives and approaches, as well as to investigate the evolution of the phenomenon of social dissatisfaction in Iranian society. Moreover, the method of causal layered analysis (CLA) was used to analyze and explain the underlying causes that contribute to social dissatisfaction in Iran.This method incorporates the examination of four distinct layers: the litany, social/systemic causes, discourse/worldview, and myth/metaphor. The litany layer represents the surface level, encompassing the most evident and objective aspects of the future. The social/systemic layer involves exploring the technological, social, economic, historical, political, and environmental causes associated with the subject matter. The discourse layer encompasses efforts to comprehend linguistic, cultural, and social structures that shape and pertain to the future. Lastly, the myth/metaphor layer delves into the investigation and exploration of schemas, mental images, and underlying narratives.The researchers collected the data by administering an open semi-structured questionnaire to a total of 10 experts. The collected data was subjected to review by 5 additional experts, who were asked to confirm the identified causes and related factors with the ultimate aim of ensuring the validity and reliability of the data. Based on the degree of consensus and frequency, the identified causes were categorized into three levels: systemic, discursive, and metaphorical. Furthermore, the researchers developed scenarios of social dissatisfaction by sharing the collected data with 5 experts, who were requested to envision future dissatisfaction scenarios in the 2031 horizon across three categories: desirable, possible, and probable. Results and DiscussionAfter conducting a review of relevant literature and collecting insights from 10 experts, the present study examined and analyzed the causes and factors contributing to social dissatisfaction the Islamic Republic in three layers: systemic, discursive, and metaphorical. At the systemic level, various factors were identified and discussed, including the prevalence of poverty, increasing discrimination, widening class gap and increasing Gini coefficient, evolving societal lifestyles, widespread feelings of deprivation, unjust distribution of national resources, and unsustainable development, etc.In the discursive layer, various causes and factors were identified and analyzed, including the historical mistrust towards the political sphere, the duality of the Islamic Revolution and the Islamic Republic of Iran, the Shia culture and thought, the modern thought and worldview, the discourse of transformation, the discourse of Western development, and the alienation of political governance, etc. Moving to the metaphorical/mythical layer, factors such as the portrayal of the government as a bandit in Iranian culture, the usurpation of power by the state, the metaphor of the Alavi government, and historical transformation-seeking were recognized and discussed as influential elements in the development of social dissatisfaction.Moreover, in accordance with expert opinions, three scenarios (desirable, possible, and probable) were formulated and constructed regarding the future of social dissatisfaction in Iran. In the desirable scenario, effective reformist measures and the realization of the right to protest would lead to a reduction in social dissatisfaction, putting protests within a legally recognized framework. In the possible scenario, considering the continuation and exacerbation of underlying causes of dissatisfaction, we would witness the accumulation of social dissatisfaction and the emergence of intermittent episodes of violent social protests. Finally, according to the probable scenario, civil disobedience would arise as a result of the prevailing security-focused approach and the rising costs of engaging in protests.ConclusionSocial dissatisfaction remains a significant issue in Iran, posing considerable challenges to political stability and national security. Effective policymaking and management concerning social dissatisfaction initially requires a comprehensive and accurate understanding of this complex issue. In this line, the present study used the CLA method as an effective approach to examine different causal layers and drivers and their impact on social dissatisfaction. The results indicated that the Islamic Republic of Iran aims to move towards its desired scenario, which involves reducing dissatisfaction and implementing a persuasive and systematic approach to managing social protests. However, given the current circumstances, attaining this scenario proves to be challenging. Instead, the possible scenario entails the continued accumulation of dissatisfaction and ongoing social protests, which will pose a significant challenge to the political stability of the Islamic Republic of Iran. Protests will be characterized by increased violence, potentially leading the political system to adopt a hard approach in suppressing and managing social unrest. This, in turn, may exacerbate radicalism and further fuel social dissatisfaction. The probable scenario, characterized by intermittent and costly protests as well as civil disobedience, presents an alternative outlook for the future of social dissatisfaction. In this scenario, social dissatisfaction manifests itself through intermittent protests that occur at various intervals and in response to specific events. As social dissatisfaction continues to evolve and persist, some citizens may resort to civil disobedience and divergence from official values and norms.

Objective(s): Immunotherapy has changed the landscape of oncology over the last decade and has become a standard of care for various cancers. Researchers previously demonstrated that B16-F10 melanoma in C57Bl6 mice is resistant to immune checkpoint inhibitors. The goal of this study was to investigate how anti-PD1 antibodies functioned in combination with a new antimicrobial peptide (AMP) called moronecidin-like peptide (MLP).Materials and Methods: We studied the cytotoxic effect of AMP on the B10-F16 tumor cell line with the MTT experiment. The necrotic and apoptotic cells were determined by Presidium iodide (PI) /Annexin V staining and flow cytometry-based methods. Mice were inoculated subcutaneously with B10-F16 tumor cells in the mammary gland. Each group was sacrificed two weeks after the last injection to examine tumor-specific CD8+ T cell responses using flow cytometry. Results: Annexin V and PI staining assay revealed that MPL significantly induces apoptosis in B16F10 cells. It should be noted that MLP in combination with anti-PD-1 improved antigen-specific T-cell responses synergistically (P=0.01) when compared with respective monotherapy. Furthermore, when compared with the respective monotherapies, combination therapy significantly controlled tumor growth in B10-F16 tumor cells and increased survival rate.Conclusion: Treatments with anti-PD-1 inhibitors alone had only a minor effect on tumor size, whereas combination therapy resulted in significant tumor growth control and increased animal survival. MLP therapy combined with anti-PD-1 antibody improves anti-tumor immune response in addition to inducing tumor cell apoptosis. As a result, the evidence suggests that intratumoral injection of MPL can improve anti-PD-1 antibody antitumor response.

Background and purpose: Appendicitis is one of the reasons for abdominal pain and the most common cause of referral to pediatric emergency departments. There are different results on the frequency and complications of appendicitis during COVID-19 pandemic. This study aims to compare the frequency and complications of acute appendicitis in children who underwent laparotomy before and during the COVID-19 pandemic in Babol Children's Hospital, north of Iran. Materials and methods: This retrospective study was conducted in 172 children with acute appendicitis who underwent laparotomy. Children were divided into two groups according to the time of referral; before the COVID-19 pandemic (between December 2018 and November 2019) and during the pandemic (between March 2019 and February 2020). Surgeon’s observations in laparotomy and also the complications (perforation, abscess, gangrene, and peritonitis) were recorded. Data analysis was carried out using Chi-score and paired t-test. Results: The children studied included 94 before the COVID-19 pandemic and 78 during the pandemic. The average age was 7.76±2.89 years. Findings showed that 165 (95.9%) and 7 (4.1%) children had confirmed and unconfirmed appendicitis, respectively, indicating no significant difference between the two groups (P=0.45). The complications of appendicitis (perforation, gangrene, abscess, and peritonitis) were 8.25% before the pandemic and 34.2% during the pandemic (P=0.24). There was no significant difference between the two groups in average time interval between the onset of pain and attending the hospital (P=0.38). Conclusion: In this study, the COVID-19 pandemic did not affect the frequency of acute appendicitis in children. These results probably indicate the proper performance of the treatment staff and the parents' rapid response to their child’s acute abdominal symptoms during the pandemic.

Iran is one of the few countries that has experienced seven decades of development planning; Parallel to the beginning of development planning in Iran, the Plan Organization was established and has always been responsible for this in Iran. In practice, development planning in Iran has not been successful and Iran has not been able to enter the group of developed countries. Different thinkers have criticized this failure of development plans in Iran from different perspectives. This research has studied the development planning system in Iran from the perspective of the developmental state's theoretical framework. This approach has a special emphasis on the existence of the pilot agency as the institution of development custodian within a developmental state; In this research, the feasibility of the Plan and Budget Organization being the pilot agency of Iran in terms of structure and tools and achieving the developmental goals of the developmental state has been investigated. In general, although the Plan and Budget Organization has some important characteristics in playing a role as a pilot agency, but for the coherence of the tools and the promotion of the organization's activity as the institution of development custodian, it needs important changes in the bureaucracy and organizational structure.

This study explores the fabrication and characterization of a pure copper electrode for an EDM equipment using laser powder bed fusion (LPBF) and comparing its performance with an original cast sample. The microstructural, mechanical, electrical, thermal, and corrosion characteristics of the samples were analyzed. The microstructure of the additively manufactured (AM) sample exhibited superior mechanical properties, with an 18 % increase in ultimate tensile strength and more than two times greater elongation in comparison with those of the cast sample. Moreover, the electrical and thermal conductivity coefficients of the AM sample were found to be consistent with industry standards as 5.52 × 107 S/m and 361 W/mK, respectively. Additionally, the potentiodynamic polarization corrosion test results of the AM sample further exhibited superior corrosion resistance in terms of the corrosion potential particularly in a 3.5 % NaCl environment. Advanced electron microscopy techniques were used to investigate the differences in the properties of the AM and cast samples and further shed light on the superior properties of the LPBF counterpart. Despite challenges in manufacturing pure copper components through LPBF, this study demonstrates the feasibility of producing a functional part that competes effectively with cast counterparts and excels in certain aspects.

[This corrects the article DOI: 10.1371/journal.pone.0274104.].

Background and purpose: Acute liver failure is caused by several factors including drugs. Isoniazid, which is used as an effective drug in treatment of tuberculosis, is considered a strong toxic agent for the liver. The purpose of this study was to investigate the effects of cinnamon extract on isoniazid-induced hepatotoxicity in rats. Materials and methods: In this experimental study, 60 male Wistar rats were randomly divided into six groups. Liver damage and oxidative stress were induced by administration of isoniazid (300 mg/kg/day) for 14 consecutive days. Different doses of cinnamon extract (50, 100, and 200 mg/kg) were administered by gavage. Liver damage caused by isoniazid was evaluated by examining serum biochemical factors, amount of reactive oxygen species, glutathione, antioxidant capacity, lipid peroxidation, and histopathological changes in liver tissue. Data analysis was performed in Prism software applying one-way analysis of variance (ANOVA) and Tukey's post hoc test. Results: Isoniazid at 200 mg/kg caused liver damage and significantly increased liver damage biomarkers (biochemical biomarkers, oxidative stress indices, and histopathological changes) (P

Background and purpose: Multisystem Inflammatory Syndrome in Children (MIS-C) occurs after having COVID-19. The severity and outcomes of COVID-19 with gastrointestinal symptoms are higher. The aim of this study was to investigate gastrointestinal manifestations in MIS-C patients in selected referral hospitals in Iran to obtain comprehensive information about the treatment and prevention of MIS-C. Materials and methods: In this cross-sectional study, all MIS-C patients

The objective of this study was to conduct preclinical immunogenicity and efficacy studies with several therapeutic vaccines for human papillomavirus (HPV)-16-associated cancers expressing the early antigens E5, E6, and E7 with or without E2. The viral oncoproteins were either expressed by themselves as fusion proteins or the fusion proteins were inserted genetically into herpes simplex virus (HSV)-1 glycoprotein D (gD) which, upon binding to the herpes virus entry mediator (HVEM), inhibits an early T cell checkpoint mediated by the B and T cell mediator (BTLA). This, in turn, lowers the threshold for T cell activation and augments and broadens CD8+ T cell responses to the antigens. The fusion antigens were expressed by chimpanzee adenovirus (AdC) vectors. Expression of the HPV antigens within gD was essential for vaccine immunogenicity and efficacy against challenge with TC-1 cells, which express E7 and E6 of HPV-16 but neither E5 nor E2. Unexpectedly, inclusion of E2 increased both CD8+ T cell responses to the other oncoproteins of HPV-16 and the effectiveness of the vaccines to cause the regression of sizable TC-1 tumors.

Objective. This study aim to evaluate the level of vitamin D with the incidence of febrile seizure. Method. This case-control study was conducted on 90 febrile children referred to Amirkola Children’s Hospital from 19 February to 21 August 2021. Febrile children with and without seizures were considered as case and control groups, respectively. Vitamin D, calcium, phosphorus, and alkaline phosphatase were evaluated. Results. The mean level of vitamin D was not significant between the 2 groups ( P = .62), but the mean level of alkaline phosphatase was higher in the case group, statistically ( P = .04). 46.75% and 15.6% of case group, 28.9% and 26.7% of control group had deficiency and insufficiency levels of vitamin D, respectively ( P = .17). Conclusion. In this study the mean level and deficiency of Vitamin D were not significant between the 2 groups. No correlation was also found between Vitamin D levels and the incidence of Febrile Seizure.

Background: We aimed to assess the in vitro effects of the green synthesized silver nanoparticles (Ag NPs) via Thymus vulgaris (thyme) against Leishmania major infection. Methods: We have prepared T. vulgalis silver nanoparticles (TSNPs) by adding thyme extract to the silver nitrate aqueous solution (0.2 mM), and evaluated their antileishmanial activity. The viability of L. major promastigotes was assessed in the presence of various concentrations of TSNPs by direct counting after 24 h. The MTT assay was used to identify the viability of promastigotes. The same procedures were assessed in uninfected macrophage cells. The apoptotic effects of nanoparticles on L. major promastigotes were determined by flow cytometry assay using annexin staining. To evaluate anti-amastigotes activity of TSNPs, light microscopic observation was used to determine the number of parasites within the macrophages in each well. Results: The effect of TSNPs on promastigotes and amastigotes of L. major was effective and had a reverse relationship with its concentration. TSNPs, inhibited the growth rate of L. major amastigotes and, the IC50 value of these nanoparticles was estimated 3.02 µg/mL (28 µM) after 72h. The results of flow cytometry showed that the toxic effects of TSNPs on promastigotes after 24 hours were statistically significant (P

Molavi is one of the poets and writers who has paid much attention, in his works, to the influence of words on the audience and to arousing them. One of the reasons for this claim is, in addition to his direct references to observe the audience's situation, that there are convergent, explanatory, and divergent questions in Masnavi-ye-Ma‘navi, which activates thought and creates positive change. The present study has first collected the questions in the First Book of Masnavi-ye-Ma‘navi, then, while separating educational questions, it has provided educational functions for them based on their arousal in the audience. Having studied and selected the sample, and collected the data, the researchers used the method of qualitative content analysis to analyze the data. The result of this study is that the educational questions of the First Book of Masnavi-ye-Ma‘navi are extracted in functions such as creating reminders, accepting inability, paying attention to and focusing on a subject, revealing neglect and ignorance, by removing neglect, demanding reasoning, expanding insight and knowledge, removing doubt, expressing regret and trying to compensate, asking Allah, and asking others. Teachers can use questions in the functions that were extracted from Masnavi-ye-Ma‘navi to rouse, resolve training and educational problems, develop students’ creativity and logical thinking.

Abstract In this study, regarding the Third Divan of Hakim Rokna (known as Masih Kashani), the meaning of the phrase(به طرح دادن) ‘be tarh dadan’ is investigated. It is one of the controversial combinations, although it has been studied and discussed for centuries, not only has it not reached a conclusion, but everyone has gone wrong in its interpretation. The phrase is dealt with firstly based on a comprehensive study, especially by witnessing the verse of Hakim in one of the sonnets of the Third Divan. The results of this study can be an end to all verbal disputes, meaningless phrases, and incorrect arguments of the authors on the meaning of this combination, since the poet completely clarified the issue by bringing the simile of(به خرمن دادن) ‘be kharman dadan’, which is a sign of abundance, along with the combination of ‘be tarh dadan’. In the examples from other books mentioned in the study, considering the issues before and after it, this point is very clear. However, the verse of Hakim is:ما بلبلیم لیک به گلشن نمی رویم تا گل به ما به طرح و به خرمن نمی‌دهند/Maa bolbolim lik be golshan nemiravim/ /Taa gol be maa be tarh o be kharman nemidehand/Translation: We are nightingales, so we don't go to garden; Until they don't give flowers to us, to.…{be tarh o be kharman}And it is clear that the meaning of this combination in Persian poetry and prose does not match the meaning of Golestan commentators and commentators of other books, and by presenting these incorrect interpretations, they only cause readers and researchers to wander.Then, the Turkish word ‘song’ and ‘Kharabeh-Dehe Song’ and other derivatives and their origins are investigated and different aspects of their meanings are depicted. Then, the importance of the combination of ‘sineh kardan’ is mentioned.IntroductionAfter the emergence of any language, during the history of that language and in different periods, many changes and transformations appear within that language, Persian language is also one of the languages that is not exempted from this rule. The interference with other cultures, the expansion of linguistic needs, and the development of the culture and literature of each country are among the factors that require these changes and lead to the creation and expansion of new words and combinations. Two combinations of ‘be tarh dadan’ and ‘sineh kardan’ and the Turkish word ‘song’ and derivatives that were taken from it helped to express linguistic intentions. And some of them have been popular for a while and some have taken root in the text of culture and have become permanent. This study aimed to find the correct meaning of these words and combinations, which are found in most of the poets' books and the speech of street and bazaar people. We should provide a more precise form of reliable Arabic words in order to reach the correct meaning, especially in the case of ‘be tarh dadan’. This study tries to answer two research questions: 1) When and why did these definitions and terms appear in the field of language? 2) Have they played a role in the enrichment of culture and language? How?Materials and MethodsIn this study, the combinations are investigated according to the explanations of Golestan Saadi, historical books such as Tarikh Sistan, Tarikh Wassaf, and Zubda al-Tawarikh, Tazkirah books such as Tazkirah Nasrabadi, commentaries such as Marzban Nameh, Attar’s Mantegh Al-tair, Anwari’s Divan, Turkish and Arabic dictionaries such as Al-Maajam Al-Wasit, Saeb’s Collection of Poems, Turkish Vocabulary Dictionary (Souzlok), and Nasiri Dictionary. However, it is worth mentioning that it was not possible to search in all sources other than the mentioned ones to clarify the meaning of the word combinations.Research FindingsBy researching the texts and with the help of Hakim's poems in the Third Divan, the meaning of the words is clarified as follows:Be Tarh Dadan = To Donate Without StinginessThe meaning of the phrase is clarified using a phrase in Al-Ma'jam al-Wasit:طَرَحَ الشَیئَ طَرحَهُ والبناءَ و نَحوَهُTranslation: he made the building tall or expanded it.The correct meaning can also be found in a verse from Saadi’s Golestan:خرمای به طرح اگر ببخشند از اهل کرم هدر نباشد/khormay be tarh agar bebakhshand/ /az ahle karam hadar nabashad/If they donate the dates …{be tarh} it will not be a waste thing for the generous personIn Hakim Rokna’s verse:ما بلبلیم لیک به گلشن نمی رویم تا گل به ما به طرح و به خرمن نمی‌دهند/Maa bolbolim lik be golshan nemiravim/ /Taa gol be maa be tarh o be kharman nemidehand/Translation: We are nightingales, so we don't go to garden; Until they don't give flowers to us, to.…{be tarh o be kharman}The poet has accompanied the combination of ‘be tarh dadan’ with the combination of ‘be kharman dadan’. Therefore, it turned out that this combination is meant without embarrassment and with forgiveness and along with donation and indulgence everywhere.Sung, SongThe root of this word could be found in Turkish. When the Safavids came to Isfahan from Ardebil, they brought ‘song’ from Ardebil and the Turkish language into Isfahan, and the people of Isfahan also used it in their dialect. It is mostly seen in the quatrains of the 10th and 11th centuries. It means ‘loot’ and ‘Kharabe-Deh-Song’ means looted ruined village. In Turkish dictionaries, it means ‘end and follow’, ‘a gift presented to elders’, ‘hole’, ‘small, tiny, and fine’ and ‘a kind of robbery and destroying’.Sineh Kardanچون در دل خود جا کنم آن بدخو را وز صبح رخش سینه کنم پهلو را/chon dar dele khod ja konam aan badkhoo raa/ /vaz sobhe rokhash sineh konam pahloo raa/Translation: When I keep that bad-tempered (impatient) in my heart; I will thrust up my flank from her face's morningThe compound infinitive of ‘sineh kardan’ means ‘boasting’ and was used until the 6th century and the early 7th century.Discussion of Results and ConclusionsCommon words and expressions of a language contribute to its richness, and paying attention to all its aspects and all periods could have strong results in recovering their meaning, and indeed, the words and expressions and their use in texts and conversations of people should be searched with regard to social, historical, political, and economic issues. Like the verse of Hakim, who solved the problem of ‘be tarh dadan’ and the terms derived from it in his works. In addition, the position and origin of the compounds and the words ‘sineh kardan’ and ‘Song’ were revealed, and it turned out why and how the compounds made from the word Song have entered the slang literature and in writing.

This study is related to those narratives of Mathnawi which contain therapeutic points. For this purpose, the authors discovered the therapeutic and medical motifs from all Mathnawi narratives. These statements are like a medic's prescription, regardless of the narrator's name. This study showed that Rumi was familiar with medical concepts and used therapeutic propositions to induce meaning. This study showed that Rumi was familiar with medical concepts and used therapeutic propositions to induce meaning. The poet has emerged as a physician among the stories of Mathnawi. He describes physical illnesses, especially mental illnesses, and ways to treat them. The main therapeutic topics discussed in Mathnawi are related to temperament, pulmonology, and herbal medicine and treatment methods. In many narratives, the main character is involved in a physical or mental illness that has been improved by a physical or spiritual physician.

Objective: Some cationic anti-microbial peptides show a wide range of cytotoxic action versus malignant cells,which may lead to developing a novel group of antitumor medications. In the present study, the anticancer activity ofpleurocidin-like peptide WF3 isoform X2 (AMP-WF3), from the Poecilia Mexicana fish, against leukemic cell line Jurkatwas evaluated, and the cytotoxicity compared with the effects on normal cells, including peripheral blood mononuclearcells (PBMCs) and human dermal fibroblast (HDF) cells.Materials and Methods: In this experimental study, cells were treated with various dosages of AMP-WF3 for 24 hours.Using methyl thiazole tetrazolium salt reduction (MTT test), the effects of the AMP-WF3 on cell viability and toxicitywere evaluated. The impact of this peptide on apoptotic pathways was examined using flow cytometry and AnnexinV-PI stains. Additionally, the relative expression of the P53, P21, and BCL-2 genes was evaluated using a real-timepolymerase chain reaction.Results: The Jurkat cell line was more susceptible to AMP-WF3 cytotoxicity [half-maximal inhibitory concentration(IC50)=50 μM], while normal cells (PBMCs and HDF) were less susceptible. Flow cytometry verified that the apoptoticactivity of AMP-WF3 on Jurkat cells was significantly higher than that of HDF and PBMCs. Peptide-treated Jurkat cellswere associated with increased expression of P21, and P53 genes. In contrast, the changes in P21, P53, and BCL-2genes differed in PBMCs and HDF cells. In HDF cells, simultaneous increase of P21, P53, and BCL-2, and in PBMCs,only the increase of BCL-2 was observed.Conclusion: Our research showed that AMP-WF3 could be developed as a novel treatment agent with minimum sideeffects for ALL patients.

The microstructural evolution and mechanical behavior of Fe-0.2C-2.7Mn-1.2Si-0.8Al-0.3Cr (wt.%) quenching and partitioning steel were studied. Partitioning was performed at 400, 440, and 480 °C for various durations from 30 to 300 s to obtain different fractions of retained austenite. Scanning electron microscopy, dilatometry, and X-ray diffraction analysis as well as uniaxial tensile testing were employed to characterize the microstructural evolutions and mechanical properties. The resulting microstructures were primarily composed of tempered lath martensite, bainitic ferrite, retained austenite, and blocky fresh martensite. The lower partitioning temperature of 400 °C was appropriate for efficient carbon partitioning and stabilization of retained austenite at room temperature. However, the retained austenite fraction decreased with increasing partitioning temperature, due to accelerated bainite formation and carbide precipitation at higher partitioning temperatures. The tensile results revealed that all specimens had tensile strength values of more than 1128 MPa and yield strength values of over 830 MPa. Additionally, prolonging the isothermal holding time had a negative effect on the yield strength due to bainite formation, while it enhanced the elongation. Fractography analysis showed that specimens treated at the partitioning temperature of 400 °C were fractured in a relatively ductile mode, but the fracture nature altered to an intergranular mode after partitioning at higher temperatures.

Background and objective: Increasing antibiotic resistance in most bacteria has led to the development of natural antimicrobial compounds. The purpose of this study was to investigate the disinfection effect of Ajowan essential oil (EO) on the standard strain of Pseudomonas aeruginosa Methods: In this study, the essential oil was prepared by distillation of Ajowan. The components of the essential oil were separated and identified by gas chromatography (GC) and gas chromatography-mass spectrometry (GC-MS). Then the antibacterial effects of two combinations including Ajowan EO +dimethyl sulfoxide (DMSO) and glutaraldehyde 2% on standard strain of Pseudomonas aeruginosa were evaluated and determined using dilution broth and disk diffusion methods Results: The results of the study showed that the most component of the essential oil consist of: Thymol (50%), P-cymene (23.6%), and Terpinen (20.3%). The mean values of MIC in the antibacterial substances (Ajowan EO+DMSO, Glutaraldehyde 2%) were 83 and 125µg/mL respectively. The mean values of MBC for abovementioned substances were 125 and 166 µg/mL respectively. The mean diameter of the inhibition zone in the MIC concentration was 11and 12.66 mm respectively. Conclusion: According to the obtained results, Essential oils Ajowan has similar effect of glutaraldehyde 2% on Pseudomonas aeruginosa. It may be a possible substitute to glutaraldehyde in hospital disinfection purposes.

Background and purpose: Ultrasound is easily available, cheap, non-invasive and radiation-free that could be considered as an alternative to Dimercaptosuccinic Acid (DMSA) in evaluation of kidney damage. The aim of this study was to determine the prediction of kidney damage in ultrasound compared with DMSA (standard method) in children with pyelonephritis and vesicoureteral reflux. Materials and methods: This cross-sectional study was performed in children aging one month to 18 years old with pyelonephritis and vesicoureteral reflux grade 2 and higher admitted in Amirkola Children's Hospital, 2011-2020. Renal ultrasound was done in all children at admission and DMSA was done after at least 4-6 months. Then, sensitivity, specificity, and positive and negative predictive values of ultrasound were studied. The kappa coefficient was determined for the percentage agreement between ultrasound and DMSA. Results: Out of 220 children with pyelonephritis and reflux, 153 were included in the study. In ultrasound, out of 306 kidneys, 262 (85.6%) and 44 (15.1%) were normal and abnormal, respectively, but DMSA showed 128 (41.8%) normal and 178 (58.2%) abnormal kidneys. The sensitivity and specificity of ultrasound in predicting kidney damage compared with DMSA were 19% (CI: 12-27%) and 86% (CI: 97-74%), respectively. The positive and negative predictive values of ultrasound compared with DMSA in predicting kidney damage were 82% (CI: 68-68%) and 24% (CI: 17-31%), respectively. Conclusion: Based on current study, ultrasound alone is not able to predict kidney damage following pyelonephritis and vesicoureteral reflux and DMSA should be performed. If the ultrasound is normal, the chances of detecting kidney damage are much lower in DMSA.

One of the important issues in the theoretical framework of the developmental state as one of the important theories in the field of development studies is the activity of the pilot agencies in the countries under study. The naming of the Ministry of Industry, Mining and Trade in Iran and the type of missions assigned to this ministry in the development plans indicate the perception of the development planners in the country about the position of this ministry as the pilot agency in Iran. But the research question is, based on the theoretical framework of the pilot agency in developmental states, what is the organizational model of the pilot agency in Iran and to what extent it matches the characteristics of the Ministry of Industry, Mines and Trade. To answer this question, a qualitative research strategy based on textual data with semi-structured interview method and qualitative data content analysis was used. The characteristics of the pilot agency are explained in this article in the five issues of approach, field of activity, policy tools, mission and organizational structure and human resources. The results of the article show that the most important identified challenges are in the areas of approach and division of work, and in the area of tools, mission and organizational structure, challenges have emerged relatively.

Background: Job satisfaction and the quality of work life are measured as indicators of organizational development in many studies.Work’s nurses affected from this two variables .This research aims to study the relationship between quality of work life and job satisfaction among nurses. Methods: This was a descriptive analytic study. Research population included 538 nurses in Golestan hospital in Ahvaz in 2020. 111 nurses were selected through simple random sampling. Data collection instruments were Walton quality of work life and Whiskey and Chrome job satisfaction questionnaires. The reliability and validity were measured. Data were analyzed through descriptive statistics, Pearson correlation analysis, independent t-test and ANOVA in SPSS20. Results: In this study, 32.40 % of the participants were male and 67.60 % were female. Quality of work life and job satisfaction showed a significant and moderate correlation (r = 0.36, P-value < 0.001). Results indicated a significant correlation between job satisfaction and components of quality of work life (P-value< 0.05), except for the general atmosphere of working life (P-value> 0.05). There was no significant correlation between the study's variables and demographic characteristics. Conclusion: There is a significant relation between the quality of work life and job satisfaction. Job satisfaction among nurses in Ahvaz hospitals can be increased by implementing programs to improve the quality of work life.

Background: Pyelonephritis in children is a serious condition that is commonly encountered in clinical practice. Urinary tract abnormalities increase the risk of urinary tract infections (UTIs) and consequently antibiotic resistance. Our study aimed to evaluate the local trend in terms of bacterial uropathogen resistance in Babol, Iran, in children with pyelonephritis considering urinary tract abnormalities. Methods: We recruited pediatric cases aged 1 month to 18 years who were admitted to Amirkola hospital with a diagnosis of pyelonephritis from 2016 to 2019. Children with negative urine cultures or incomplete imaging were excluded from the study. Causative agents were identified based on biochemical features. Antimicrobial in vitro resistance tests were performed using the disk diffusion agar test. Results: A total of 105 children were included in the study. E. coli was the most common causative agent found in 93 (88.6%) patients. Most of the bacterial isolates were sensitive to amikacin and imipenem, and only 12.4% and 13.3% of isolates were resistant to this antibiotic. On the other hand, nalidixic acid represented the least effective treatment, with a resistance rate of 88.6%. A statistically significant difference was observed in resistance to nitrofurantoin and nalidixic acid between children with and without anomalies (p < 0.05). Conclusion: High antibiotic resistance, especially in children with urinary tract anomalies, was identified for frequently used antibiotics. Our findings provide important implications regarding local patterns of uropathogens and antibiotic resistance in children with pyelonephritis.

As robots more frequently fraternize with humans in everyday life, aspects such as safety, flexibility of tasks, and appearance become increasingly important. Soft robotics is attractive for new human‐close applications, but soft actuators constitute a major challenge both in terms of actuation force and speed, and in terms of control and accuracy of the deformable soft actuator body. Herein, several of these challenges are addressed by developing versatile ultrasoft electromagnetic actuators that operate in absence of external magnetic fields, while simultaneously monitoring their states by internal strain sensors. The versatile actuators can compress to less than 50% of their initial length with strain‐independent contraction force and operate in both contraction and expansion modes up to 200 Hz frequency while conforming to curved surfaces. The soft multilayer conductive cellulose‐based foams are lightweight (3 mg cm−3) and provide internal strain‐sensing capability and structural support, thereby improving the monitoring and controllability of the actuators while maintaining an axial softness of 0.6 kPa. It is believed that the concept of soft versatile electromagnetic actuators with integrated lightweight strain‐sensing foams is promising for a wide range of applications within soft robotics.

Economic complexity is a relatively new concept developed in recent years to assess the productive characteristics of countries. It not only explains the production structure, but also helps examine differences in income and growth across countries. In this paper, we estimate the macroeconomic impact of economic complexity on growth of a sample of N-11 countries for the period 2000-2020, using the economic complexity index developed by Hidalgo and Hausman (2009). Diagnostic tests confirmed the assumption of slope coefficient heterogeneity and cross-sectional dependence of the error term. Thus, we employ the Pesaran (2006) Common Correlated Effects Mean Group estimator (CCEMG) and the Chudik and Pesaran (2015) Common Correlated Effect Pooled Mean Group (CCEPMG) methodology. The findings suggest that economic complexity is one of the key determinants of long-term economic growth. However, its impact on economic growth is not significant in the short term, suggesting that the impact of changes in production structure on economic growth is time-sensitive. The coefficients of other control variables such as human capital, investment, institutional quality, and inflation rate were statistically significant.