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1. Epidemiology of heart failure and long-term follow-up outcomes in a north-African population: Results from the NAtional TUnisian REgistry of Heart Failure (NATURE-HF).

Author

Leila Abid, Salma Charfeddine, Ikram Kammoun, Manel Ben Halima, Hedi Ben Slima, Meriem Drissa, Khadija Mzoughi, Dorra Mbarek, Leila Riahi, Saoussen Antit, Afef Ben Halima, Wejdene Ouechtati, Emna Allouche, Mehdi Mechri, Chedi Youssfi, Ali Khorchani, Kais Sammoud, Khaled Zaouia, Rami Tlili, Sana Ouali, Faten Triki, Sonia Hamdi, Selim Boudich, Marwa Chebbi, Mouna Hentati, Amani Farah, Habib Triki, H Ghardallou, H Radoui, Sofien Zayed, F Azaiez, Fadoua Omri, Akram Zouari, Zine Ben Ali, A Najjar, Houssem Thabet, Mouna Chaker, Samar Mohammed, Abdelhamid Ben Jmaa, Haithem Tangour, Yassine Kammoun, Mahmoud Cheikh Bouhlel, S Azeiz, R Gtaief, S Mashki, Aymen Amri, Hela Naanea, Raoudha Othmani, Iheb Chahbani, Houcine Zargouni, Syrine Abid, Mokded Ayari, Ines Ben Ameur, Ali Guesmi, Nejeh Ben Halima, Habib Haouala, Wafa Fehri, Essia Boughzela, Lilia Zakhama, Soraya Ben Youssef, Wided Nasraoui, Rachid Boujneh, Nedia Barakett, Sondos Kraiem, Hbiba Drissa, Ali Ben Khalfalah, Habib Gamra, Salem Kachboura, Yosra Majdoub, Elifa Kanoun, Faiez Zannad, Sami Milouchi, Alexandre Mebaza, Samir Kammoun, Sami Mourali, Karima Hezbri, and Faouzi Addad

Subjects
Medicine, Science
Abstract

The NATURE-HF registry was aimed to describe clinical epidemiology and 1-year outcomes of outpatients and inpatients with heart failure (HF). This is a prospective, multicenter, observational survey conducted in Tunisian Cardiology centers. A total of 2040 patients were included in the study. Of these, 1632 (80%) were outpatients with chronic HF (CHF). The mean hospital stay was 8.7 ± 8.2 days. The mortality rate during the initial hospitalization event for AHF was 7.4%. The all-cause 1-year mortality rate was 22.8% among AHF patients and 10.6% among CHF patients. Among CHF patients, the older age, diabetes, anemia, reduced EF, ischemic etiology, residual congestion and the absence of ACEI/ ARBs treatment were independent predictors of 1-year cumulative rates of rehospitalization and mortality. The female sex and the functional status were independent predictors of 1-year all-cause mortality and rehospitalization in AHF patients. This study confirmed that acute HF is still associated with a poor prognosis, while the mid-term outcomes in patients with chronic HF seems to be improved. Some differences across countries may be due to different clinical characteristics and differences in healthcare systems.

Published
2021
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2. Epidemiology of heart failure and long-term follow-up outcomes in a north-African population: Results from the NAtional TUnisian REgistry of Heart Failure (NATURE-HF)

Author

Sofien Zayed, Faiez Zannad, Habib Gamra, Marwa Chebbi, Khadija Mzoughi, Aymen Amri, S Mashki, Manel Ben Halima, Hela Naanea, Syrine Abid, Ali Ben Khalfalah, Salma Charfeddine, Samar Mohammed, A Najjar, Sondos Kraiem, Wided Nasraoui, Kais Sammoud, E. Boughzela, Emna Allouche, Nedia Barakett, Abdelhamid Ben Jmaa, Haithem Tangour, Fadoua Omri, S Azeiz, Ali Khorchani, Lilia Zakhama, Akram Zouari, Mokded Ayari, S. Milouchi, Faten Triki, Sami Mourali, Amani Farah, H Radoui, Alexandre Mebaza, Iheb Chahbani, Sana Ouali, Soraya Ben Youssef, Leila Riahi, Rami Tlili, Saoussen Antit, Hedi Ben Slima, Dorra Mbarek, Ines ben Ameur, Habib Haouala, Wafa Fehri, F. Addad, Chedi Youssfi, Khaled Zaouia, Houssem Thabet, Ikram Kammoun, Elifa Kanoun, Afef Ben Halima, Fares Azaiez, Wejdene Ouechtati, Zine Ben Ali, Hbiba Drissa, Mouna Hentati, Mahmoud Cheikh Bouhlel, Ali Guesmi, Houcine Zargouni, Karima Hezbri, Rachid Boujneh, Leila Abid, Mouna Chaker, Yassine Kammoun, Raoudha Othmani, H Ghardallou, Salem Kachboura, Meriem Drissa, Sonia Hamdi, R Gtaief, Yosra Majdoub, Habib Triki, Samir Kammoun, Nejeh Ben Halima, Selim Boudich, Mehdi Mechri, Tunisian Society of Cardiology and Cardiac Surgery, Hedi Chaker Hospital [Sfax], Hôpital Abderrahman Mami, Hôpital La Rabta [Tunis], Menzel Bourguiba Regional Hospital, Habib Thameur Hospital, Centre Hospitalier Universitaire Mongi Slim [La Marsa], Department of cardiology, Hospital of the Internal Security Forces, Hôpital Charles Nicolle [Tunis], Hopital Habib Bourguiba - Habib Bourguiba Hospital [Sfax], Department of cardiology, Principal Military Hospital, Department of cardiology, Habib Thameur Hospital, CHU Fattouma Bourguiba [Monastir] (HFB), Hôpital régional Taher Maamouri [Nabeul], Hôpital Universitaire Sahloul (CHU Sahloul), Hôpital Abderrahmen Mami, Hôpital Habib Thameur [Tunis], Department of cardiology, Mohamed Ben Sassi Hospital, Department of cardiology, Ibn El Jazzar Hospital, Department of cardiology, Kasserine Hospital, Mohamed Tahar Maamouri Hospital [Tunisia], Hôpital de Menzel Bourguiba, Centre National des Sciences et Technologies Nucléaires Sidi Thabet, Défaillance Cardiovasculaire Aiguë et Chronique (DCAC), Université de Lorraine (UL)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy), Centre d'investigation clinique plurithématique Pierre Drouin [Nancy] (CIC-P), Centre d'investigation clinique [Nancy] (CIC), Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lorraine (UL)-Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lorraine (UL), Cardiovascular and Renal Clinical Trialists [Vandoeuvre-les-Nancy] (INI-CRCT), Institut Lorrain du Coeur et des Vaisseaux Louis Mathieu [Nancy], French-Clinical Research Infrastructure Network - F-CRIN [Paris] (Cardiovascular & Renal Clinical Trialists - CRCT ), Hôpital Lariboisière-Fernand-Widal [APHP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), National Institute of Applied Sciences and Technology Tunis, Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lorraine (UL), and BOZEC, Erwan

Subjects
Male, 030204 cardiovascular system & hematology, Endocrinology, Medical Conditions, 0302 clinical medicine, Outpatients, Epidemiology, Medicine and Health Sciences, Prospective Studies, Registries, 030212 general & internal medicine, Aged, 80 and over, education.field_of_study, Multidisciplinary, Pharmaceutics, Mortality rate, Anemia, Hematology, Middle Aged, [SDV.MHEP.CSC] Life Sciences [q-bio]/Human health and pathology/Cardiology and cardiovascular system, 3. Good health, Survival Rate, Medicine, Female, Research Article, Adult, medicine.medical_specialty, Tunisia, Patients, Death Rates, Endocrine Disorders, Science, Population, Cardiology, Disease-Free Survival, 03 medical and health sciences, Population Metrics, Drug Therapy, [SDV.MHEP.CSC]Life Sciences [q-bio]/Human health and pathology/Cardiology and cardiovascular system, Diabetes mellitus, Internal medicine, Diabetes Mellitus, medicine, Humans, education, Aged, Heart Failure, Population Biology, business.industry, Biology and Life Sciences, medicine.disease, Health Care, Metabolic Disorders, Heart failure, Etiology, Observational study, business, Receptor Antagonist Therapy, Follow-Up Studies, Ejection Fraction
Abstract

International audience; The NATURE-HF registry was aimed to describe clinical epidemiology and 1-year outcomes of outpatients and inpatients with heart failure (HF). This is a prospective, multicenter, observational survey conducted in Tunisian Cardiology centers. A total of 2040 patients were included in the study. Of these, 1632 (80%) were outpatients with chronic HF (CHF). The mean hospital stay was 8.7 ± 8.2 days. The mortality rate during the initial hospitalization event for AHF was 7.4%. The all-cause 1-year mortality rate was 22.8% among AHF patients and 10.6% among CHF patients. Among CHF patients, the older age, diabetes, anemia, reduced EF, ischemic etiology, residual congestion and the absence of ACEI/ ARBs treatment were independent predictors of 1-year cumulative rates of rehospitalization and mortality. The female sex and the functional status were independent predictors of 1-year all-cause mortality and rehospitalization in AHF patients. This study confirmed that acute HF is still associated with a poor prognosis, while the mid-term outcomes in patients with chronic HF seems to be improved. Some differences across countries may be due to different clinical characteristics and differences in healthcare systems.

Published
2021

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