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548 results on '"Mokrousov, Igor"'

1. Insight into pathogenomics and phylogeography of hypervirulent and highly-lethal Mycobacterium tuberculosis strain cluster

Author

Mokrousov, Igor, Vyazovaya, Anna, Shitikov, Egor, Badleeva, Maria, Belopolskaya, Olesya, Bespiatykh, Dmitry, Gerasimova, Alena, Ioannidis, Panayotis, Jiao, Weiwei, Khromova, Polina, Masharsky, Aleksey, Naizabayeva, Dinara, Papaventsis, Dimitrios, Pasechnik, Oksana, Perdigão, João, Rastogi, Nalin, Shen, Adong, Sinkov, Viacheslav, Skiba, Yuriy, Solovieva, Natalia, Tafaj, Silva, Valcheva, Violeta, Kostyukova, Irina, Zhdanova, Svetlana, Zhuravlev, Viacheslav, and Ogarkov, Oleg

Published
2023
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4. Phylogenomic and genomic analysis reveals unique and shared genetic signatures of Mycobacterium kansasii complex species

Author

Machado, Edson, primary, Vasconcellos, Sidra, additional, Gomes, Lia, additional, Catanho, Marcos, additional, Ramos, Jesus, additional, de Carvalho, Luciana, additional, Goldenberg, Telma, additional, Dalcolmo, Margareth, additional, Redner, Paulo, additional, Caldas, Paulo, additional, Campos, Carlos, additional, Lourenco, Maria Cristina, additional, Lasunskaia, Elena, additional, Mussi, Vinicius, additional, Spinasse, Lizania, additional, Vinhas, Solange, additional, Rigouts, Leen, additional, Cogneau, Sari, additional, de Rijk, Pim, additional, Utpatel, Christian, additional, Kaustova, Jarmila, additional, van der Laan, Tridia, additional, de Neeling, Han, additional, Rastogi, Nalin, additional, Levina, Klavdia, additional, Kutt, Marge, additional, Mokrousov, Igor, additional, Zhuravlev, Viacheslav, additional, Makhado, Ndivhu, additional, Zolnir-Dovc, Manca, additional, Jankovic, Vera, additional, de Waard, Jacobus, additional, Sisco, Maria, additional, van Soolingen, Dick, additional, Niemann, Stefan, additional, de Jong, Bouke C., additional, Meehan, Conor J, additional, and Suffys, Philip, additional

Published
2024
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9. Practical approach to detection and surveillance of emerging highly resistant Mycobacterium tuberculosis Beijing 1071-32-cluster

Author

Mokrousov, Igor, Vyazovaya, Anna, Sinkov, Viacheslav, Gerasimova, Alena, Ioannidis, Panayotis, Jiao, Weiwei, Khromova, Polina, Papaventsis, Dimitrios, Pasechnik, Oksana, Perdigão, João, Rastogi, Nalin, Shen, Adong, Skiba, Yuriy, Solovieva, Natalia, Suffys, Philip, Tafaj, Silva, Umpeleva, Tatiana, Vakhrusheva, Diana, Yarusova, Irina, Zhdanova, Svetlana, Zhuravlev, Viacheslav, and Ogarkov, Oleg

Published
2021
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12. Insight into Population Structure and Drug Resistance of Pediatric Tuberculosis Strains from China and Russia Gained through Whole-Genome Sequencing

Author

Zhdanova, Svetlana, primary, Jiao, Wei-Wei, additional, Sinkov, Viacheslav, additional, Khromova, Polina, additional, Solovieva, Natalia, additional, Mushkin, Alexander, additional, Mokrousov, Igor, additional, Belopolskaya, Olesya, additional, Masharsky, Aleksey, additional, Vyazovaya, Anna, additional, Rychkova, Lubov, additional, Kolesnikova, Lubov, additional, Zhuravlev, Viacheslav, additional, Shen, A-Dong, additional, and Ogarkov, Oleg, additional

Published
2023
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19. Exhibition of persistent and drug-tolerant L-form habit of Mycobacterium tuberculosis during infection in rats

Author

Markova, Nadya, Michailova, Lilia, Jourdanova, Mimi, Kussovski, Vesselin, Valcheva, Violeta, Mokrousov, Igor, and Radoucheva, Tatyana

Abstract

Abstract: A model for studying mycobacterial L-form formation in vivo was established to demonstrate the ability of M. tuberculosis to behave as a drug-tolerant L-form persister. Rats were infected by intranasal (i.n.) and intraperitoneal (i.p.) routes with 1×108 cells/ml of M. tuberculosis. At weekly intervals during a period of five weeks, samples from lung, spleen, liver, kidney, mesenterial and inguinal lymph nodes, broncho-alveolar and peritoneal lavage liquid were plated simultaneously on Löwenstein-Jensen (LJ) medium or inoculated into specially supplemented for L-forms Dubos broth (drug-free and drug-containing variants). The use of liquid media enabled isolation of mycobacterial L-form cultures during the whole period of experiment including the last two weeks, when tubercle bacilli were not isolated on LJ medium. An unique feature of mycobacterial L-forms was their ability to grow faster than the classical tubercle bacilli. Isolation and growth of L-form cultures in primary drug-containing media demonstrated their drug-tolerant properties. Electron microscopy of liquid media isolates showed that they consisted of morphologically heterogenous populations of membrane-bound and of variable sized L-bodies that completely lack cell walls. The identity of the isolated non-acid fast and morphologically modified L-forms as M. tuberculosis was verified by specific spoligotyping test. The results contribute to special aspects concerning the importance of mycobacterial L-form phenomenon for persistence and latency in tuberculosis, phenotypic drug tolerance, as well as for diagnosis of difficult to identify morphologically changed tubercle bacilli which are often mistaken for contaminants.

Published
2024
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23. Diphtheria

Author

Sharma, Naresh Chand, Efstratiou, Androulla, Mokrousov, Igor, Mutreja, Ankur, Das, Bhabatosh, and Ramamurthy, Thandavarayan

Published
2019
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24. Whole-Genome Analysis of Mycobacterium tuberculosis from Patients with Tuberculous Spondylitis, Russia

Author

Chernyaeva, Ekaterina, Rotkevich, Mikhail, Krasheninnikova, Ksenia, Yurchenko, Andrey, Vyazovaya, Anna, Mokrousov, Igor, Solovieva, Natalia, Zhuravlev, Viacheslav, Yablonsky, Piotr, and OBrien, Stephen J.

Subjects
Spondylitis -- Genetic aspects -- Analysis, Virulence (Microbiology) -- Analysis, Microbial drug resistance -- Genetic aspects -- Analysis, Genomes -- Analysis, Tuberculosis -- Genetic aspects -- Analysis, Rifampin -- Analysis, Genomics -- Analysis, Health
Abstract

Tuberculosis (TB) is an infectious disease caused by Mycobacterium tuberculosis, which typically affects the lungs but can affect other sites. In 2016, an estimated 10.4 million new TB cases and [...]

Published
2018
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26. Additional file 1 of Insight into pathogenomics and phylogeography of hypervirulent and highly-lethal Mycobacterium tuberculosis strain cluster

Author

Mokrousov, Igor, Vyazovaya, Anna, Shitikov, Egor, Badleeva, Maria, Belopolskaya, Olesya, Bespiatykh, Dmitry, Gerasimova, Alena, Ioannidis, Panayotis, Jiao, Weiwei, Khromova, Polina, Masharsky, Aleksey, Naizabayeva, Dinara, Papaventsis, Dimitrios, Pasechnik, Oksana, Perdigão, João, Rastogi, Nalin, Shen, Adong, Sinkov, Viacheslav, Skiba, Yuriy, Solovieva, Natalia, Tafaj, Silva, Valcheva, Violeta, Kostyukova, Irina, Zhdanova, Svetlana, Zhuravlev, Viacheslav, and Ogarkov, Oleg

Abstract

Supplementary Material 1

Published
2023
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29. Mycobacterium tuberculosis RD-Rio Strain in Kazakhstan

Author

Skiba, Yuriy, Mokrousov, Igor, Nabirova, Dilyara, Vyazovaya, Anna, Maltseva, Elina, Malakhova, Natalya, Ismagulova, Gulnara, Pole, Ilva, Ranka, Renate, Sapiyeva, Zhanar, Ismailov, Shakhimurat, and Moffett, Daphne

Subjects
Drug resistance -- Analysis, Tuberculosis -- Analysis, Health
Abstract

The RD-Rio strain of Mycobacterium tuberculosis was initially described in Rio de Janeiro, Brazil, and was demonstrated to be spread beyond South America (1). However, RD-Rio isolates are rare in [...]

Published
2019
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32. Genetic diversity of the Mycobacterium tuberculosis Beijing family in Brazil and Mozambique and relation with infectivity and induction of necrosis in THP-1 cells

Author

Gomes, Lia Lima, Vasconcellos, Sidra Ezidrio Gonçalves, Gomes, Harrison Magdinier, Elias, Atina Ribeiro, da Silva Rocha, Adalgiza, Ribeiro, Simone C.M., Panunto, Alessandra Costa, Ferrazoli, Lucilaine, da Silva Telles, Maria Alice, Ivens de, Araujo Marelo Emanuel, Kritski, Afranio Lineu, Mokrousov, Igor, Manicheva, Olga A., Lasunskaia, Elena, and Suffys, Philip Noel

Published
2015
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33. Molecular Insight into Mycobacterium tuberculosis Resistance to Nitrofuranyl Amides Gained through Metagenomics-like Analysis of Spontaneous Mutants

Author

Mokrousov, Igor, primary, Slavchev, Ivaylo, additional, Solovieva, Natalia, additional, Dogonadze, Marine, additional, Vyazovaya, Anna, additional, Valcheva, Violeta, additional, Masharsky, Aleksey, additional, Belopolskaya, Olesya, additional, Dimitrov, Simeon, additional, Zhuravlev, Viacheslav, additional, Portugal, Isabel, additional, Perdigão, João, additional, and Dobrikov, Georgi, additional

Published
2022
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37. Synthesis, Characterization and Complex Evaluation of Antibacterial Activity and Cytotoxicity of New Arylmethylidene Ketones and Pyrimidines with Camphane Skeletons

Author

Slavchev, Ivaylo M., primary, Mitrev, Yavor, additional, Shivachev, Boris, additional, Valcheva, Violeta, additional, Dogonadze, Marine, additional, Solovieva, Natalia, additional, Vyazovaya, Anna, additional, Mokrousov, Igor, additional, Link, Wolfgang, additional, Jiménez, Lucía, additional, Cautain, Bastien, additional, Mackenzie, Thomas A., additional, Portugal, Isabel, additional, Lopes, Francisca, additional, Capela, Rita, additional, Perdigão, João, additional, and Dobrikov, Georgi M., additional

Published
2022
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38. First Insight into Diversity of Minisatellite Loci in Mycobacterium bovis / M. caprae in Bulgaria.

Author

Terentieva, Daria, Savova-Lalkovska, Tanya, Dimitrova, Albena, Bonovska, Magdalena, Mokrousov, Igor, and Valcheva, Violeta

Subjects
MYCOBACTERIUM bovis, LOCUS (Genetics)
Abstract

The aim of this study was to assess the diversity of minisatellite VNTR loci in Mycobacterium bovis/M. caprae isolates in Bulgaria and view their position within global M. bovis diversity. Forty-three M. bovis/M. caprae isolates from cattle in different farms in Bulgaria were collected in 2015–2021 and typed in 13 VNTR loci. The M. bovis and M. caprae branches were clearly separated on the VNTR phylogenetic tree. The larger and more geographically dispersed M. caprae group was more diverse than M. bovis group was (HGI 0.67 vs. 0.60). Overall, six clusters were identified (from 2 to 19 isolates) and nine orphans (all loci-based HGI 0.79). Locus QUB3232 was the most discriminatory one (HGI 0.64). MIRU4 and MIRU40 were monomorphic, and MIRU26 was almost monomorphic. Four loci (ETRA, ETRB, Mtub21, and MIRU16) discriminated only between M. bovis and M. caprae. The comparison with published VNTR datasets from 11 countries showed both overall heterogeneity between the settings and predominantly local evolution of the clonal complexes. To conclude, six loci may be recommended for primary genotyping of M. bovis/M. caprae isolates in Bulgaria: ETRC, QUB11b, QUB11a, QUB26, QUB3232, and MIRU10 (HGI 0.77). VNTR typing based on a limited number of loci appears to be useful for primary bTB surveillance. [ABSTRACT FROM AUTHOR]

Published
2023
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40. Additional file 1 of Impact of pathobiological diversity of Mycobacterium tuberculosis on clinical features and lethal outcome of tuberculosis

Author

Mokrousov, Igor, Pasechnik, Oksana, Vyazovaya, Anna, Yarusova, Irina, Gerasimova, Alena, Blokh, Aleksey, and Zhuravlev, Viacheslav

Abstract

Additional file 1: Table S1. Comparison of Beijing B0/W148 and Central Asian / Russian clusters. Table S2. Comparison of Beijing B0/W148 and 1071-32 clusters. Table S3. Comparison of Beijing B0/W148 and 14717-15 clusters. Table S4. Comparison of the Beijing Central Asian Russian and 1071-32 clusters. Table S5. Comparison of Beijing Central Asian Russian and 14717-15 clusters. Table S6. Comparison of Beijing 1071-32 and 14717-15 clusters.

Published
2022
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41. Additional file 3 of Mycobacterium bovis and M. caprae in Bulgaria: insight into transmission and phylogeography gained through whole-genome sequencing

Author

Valcheva, Violeta, Perea, Claudia, Savova-Lalkovska, Tanya, Dimitrova, Albena, Radulski, Lukasz, Mokrousov, Igor, Marinov, Krustyu, Najdenski, Hristo, and Bonovska, Magdalena

Abstract

Additional file 3: Figure S1. Phylogenetic tree of Bulgarian isolates with world isolates. Based on classification by Loiseau et al., 2020 [26].

Published
2022
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42. List of contributors

Author

Abecasis, Ana B., Aiewsakun, Pakorn, Altynova, Nazym, Ansari, Afzal, Baker, Kate S., Bespiatykh, Dmitry, Bhardwaj, Neha, Burkovski, Andreas, Caetano-Anollés, Gustavo, Chodvadiya, Jaimin, Cui, Yujun, Djansgurova, Leyla, Dwivedi, Purna, Elias, Rita, Gharbi, Nour, Gomes, Pedro, González-Candelas, Fernando, Hak, Fiona, Hawkey, Jane, Huete, Samuel G., Ingle, Danielle, Jia, Chenghao, Kale, Mohan M., Kasibhatla, Sunitha Manjari, Khussainova, Elmira, Kimura, Hirokazu, Kulkarni-Kale, Urmila, Lamer, Ombeline, Le Meur, Adrien, Li, Qi, Liu, Yuhao, Luo, Tao, Miles, Sydney L., Mokrousov, Igor, Musralina, Lyazzat, Nieves, Cecilia, O’Donnell, Samuel, Palittapongarnpim, Prasit, Perdigão, João, Picardeau, Mathieu, Pingarilho, Marta, Portugal, Isabel, Qian, Xiuwei, Refrégier, Guislaine, Reva, Oleg N., de la Vega, Ricardo Rodriguez, Rousseau, Emilie, Sada, Mitsuru, Sangal, Vartul, Senelle, Gaëtan, Sharma, Mukul, Shirai, Tatsuya, Shitikov, Egor, Singh, Pushpendra, Singh, Urvashi B., Sondhiya, Gayatri, The, Hao Chung, Tibayrenc, Michel, Vaidya, Sunil R., Vandamme, Anne-Mieke, Vernadet, Jean-Philippe, Veyrier, Frédéric J., Wang, Ran, Wang, Zining, Wirth, Thierry, Wu, Yarong, Yang, Ruifu, Yue, Min, Zein-Eddine, Rima, Zhou, Haiyang, and Zuo, Xiujuan

Published
2024
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45. Prevalence of the epidemic variants of the Mycobacterium tuberculosis Beijing genotype across Russian regions

Author

Mokrousov, Igor, primary, Vyazovaya, Anna, additional, Zhdanova, Svetlana, additional, Umpeleva, Tatiana, additional, Badleeva, Maria, additional, Yarusova, Irina, additional, Gerasimova, Alena, additional, Mudarisova, Regina, additional, Solovieva, Natalia, additional, Eremeeva, Natalia, additional, Vakhrusheva, Diana, additional, Pasechnik, Oksana, additional, Ogarkov, Oleg, additional, and Zhuravlev, Viacheslav, additional

Published
2021
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46. Highly lethal strain cluster of the Mycobacterium tuberculosis Beijing genotype endemically prevalent in Buryatia, Russia

Author

Mokrousov, Igor, primary, Vinogradova, Tatiana, additional, Dogonadze, Marine, additional, Badleeva, Maria, additional, Yarusova, Irina, additional, Zabolotnykh, Natalia, additional, Vitovskaya, Maria, additional, Vyazovaya, Anna, additional, Gerasimova, Alena, additional, Zhdanova, Svetlana, additional, Khromova, Polina, additional, Sinkov, Viachelsav, additional, Molchanov, Vladimir, additional, Chernyaeva, Ekaterina, additional, Solovieva, Natalia, additional, Pasechnik, Oksana, additional, and Ogarkov, Oleg, additional

Published
2021
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