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3. STereotactic Arrhythmia Radioablation (STAR): the Standardized Treatment and Outcome Platform for Stereotactic Therapy Of Re-entrant tachycardia by a Multidisciplinary consortium (STOPSTORM.eu) and review of current patterns of STAR practice in Europe

Author

Grehn, M., Mandija, S., Miszczyk, M., Krug, D., Tomasik, B., Stickney, K. E., Alcantara, P., Alongi, F., Anselmino, M., Aranda, R. S., Balgobind, B. V., Boda-Heggemann, J., Boldt, L.-H., Bottoni, N., Cvek, J., Elicin, O., Ferrari, G. M., Hassink, R. J., Hazelaar, C., Hindricks, G., Hurkmans, C., Iotti, C., Jadczyk, T., Jiravsky, O., Jumeau, R., Kristiansen, S. B., Levis, M., López, M. A., Martí-Almor, J., Mehrhof, F., Møller, D. S., Molon, G., Ouss, A., Peichl, P., Plasek, J., Postema, P. G., Quesada, A., Reichlin, T., Rordorf, R., Rudic, B., Saguner, A. M., Ter, B., Rachel, M. A., Torrecilla, J. L., (0000-0001-9550-9050) Troost, E. G. C., Vitolo, V., Andratschke, N., Zeppenfeld, K., Blamek, S., Fast, M., Panfilis, L., Blanck, O., Pruvot, E., Verhoeff, J. J. C., Grehn, M., Mandija, S., Miszczyk, M., Krug, D., Tomasik, B., Stickney, K. E., Alcantara, P., Alongi, F., Anselmino, M., Aranda, R. S., Balgobind, B. V., Boda-Heggemann, J., Boldt, L.-H., Bottoni, N., Cvek, J., Elicin, O., Ferrari, G. M., Hassink, R. J., Hazelaar, C., Hindricks, G., Hurkmans, C., Iotti, C., Jadczyk, T., Jiravsky, O., Jumeau, R., Kristiansen, S. B., Levis, M., López, M. A., Martí-Almor, J., Mehrhof, F., Møller, D. S., Molon, G., Ouss, A., Peichl, P., Plasek, J., Postema, P. G., Quesada, A., Reichlin, T., Rordorf, R., Rudic, B., Saguner, A. M., Ter, B., Rachel, M. A., Torrecilla, J. L., (0000-0001-9550-9050) Troost, E. G. C., Vitolo, V., Andratschke, N., Zeppenfeld, K., Blamek, S., Fast, M., Panfilis, L., Blanck, O., Pruvot, E., and Verhoeff, J. J. C.

Abstract

The EU Horizon 2020 Framework-funded Standardized Treatment and Outcome Platform for Stereotactic Therapy Of Re-entrant tachycardia by a Multidisciplinary (STOPSTORM) consortium has been established as a large research network for investigating STereotactic Arrhythmia Radioablation (STAR) for ventricular tachycardia (VT). The aim is to provide a pooled treatment database to evaluate patterns of practice and outcomes of STAR and finally to harmonize STAR within Europe. The consortium comprises 31 clinical and research institutions. The project is divided into nine work packages (WPs): (i) observational cohort; (ii) standardization and harmonization of target delineation; (iii) harmonized prospective cohort; (iv) quality assurance (QA); (v) analysis and evaluation; (vi, ix) ethics and regulations; and (vii, viii) project coordination and dissemination. To provide a review of current clinical STAR practice in Europe, a comprehensive questionnaire was performed at project start. The STOPSTORM Institutions' experience in VT catheter ablation (83% ≥ 20 ann.) and stereotactic body radiotherapy (59% > 200 ann.) was adequate, and 84 STAR treatments were performed until project launch, while 8/22 centres already recruited VT patients in national clinical trials. The majority currently base their target definition on mapping during VT (96%) and/or pace mapping (75%), reduced voltage areas (63%), or late ventricular potentials (75%) during sinus rhythm. The majority currently apply a single-fraction dose of 25 Gy while planning techniques and dose prescription methods vary greatly. The current clinical STAR practice in the STOPSTORM consortium highlights potential areas of optimization and harmonization for substrate mapping, target delineation, motion management, dosimetry, and QA, which will be addressed in the various WPs. © The Author(s) 2023. Published by Oxford University Press on behalf of the European Society of Cardiology.

Published
2023

4. Elevated Serum Urea-to-Creatinine Ratio and In-Hospital Death in Patients with Hyponatremia Hospitalized for COVID-19

Author

Regolisti, G, Rebora, P, Occhino, G, Lieti, G, Molon, G, Maloberti, A, Algeri, M, Giannattasio, C, Valsecchi, M, Genovesi, S, Regolisti, Giuseppe, Rebora, Paola, Occhino, Giuseppe, Lieti, Giulia, Molon, Giulio, Maloberti, Alessandro, Algeri, Michela, Giannattasio, Cristina, Valsecchi, Maria Grazia, Genovesi, Simonetta, Regolisti, G, Rebora, P, Occhino, G, Lieti, G, Molon, G, Maloberti, A, Algeri, M, Giannattasio, C, Valsecchi, M, Genovesi, S, Regolisti, Giuseppe, Rebora, Paola, Occhino, Giuseppe, Lieti, Giulia, Molon, Giulio, Maloberti, Alessandro, Algeri, Michela, Giannattasio, Cristina, Valsecchi, Maria Grazia, and Genovesi, Simonetta

Abstract

Hyponatremia is associated with adverse outcomes in hospitalized patients. An elevated value of the serum urea-to-creatinine ratio (UCR) has been proposed as a proxy of hypovolemia. The aim of this study was to investigate the relationship between the UCR and in-hospital death in patients hospitalized with COVID-19 and hyponatremia. We studied 258 patients admitted for COVID-19 between January 2020 and May 2021 with serum sodium at < 135 mmol/L. The primary end-point was all-cause mortality. A 5-unit increase in the serum UCR during hospital stays was associated with an 8% increase in the hazard of all-cause death (HR = 1.08, 95% CI: 1.03–1.14, p = 0.001) after adjusting for potential confounders. In patients with a UCR > 40 at baseline, a > 10 mmol/L increase in serum sodium values within the first week of hospitalization was associated with higher odds of in-hospital death (OR = 2.93, 95% CI: 1.03–8.36, p = 0.044) compared to patients who experienced a < 10 mmol/L change. This was not observed in patients with a UCR < 40. Hypovolemia developing during hospital stays in COVID-19 patients with hyponatremia detected at hospital admission bears an adverse prognostic impact. Moreover, in hypovolemic patients, a > 10 mmol/L increase in serum sodium within the first week of hospital stays may further worsen the in-hospital prognosis.

Published
2023

5. Negative prognostic impact of electrolyte disorders in patients hospitalized for Covid-19 in a large multicenter study

Author

Genovesi, S, Regolisti, G, Rebora, P, Occhino, G, Belli, M, Molon, G, Citerio, G, Beltrame, A, Maloberti, A, Generali, E, Giannattasio, C, Epis, O, Rossetti, C, Bellelli, G, De Nalda, A, Capua, I, Valsecchi, M, Genovesi, Simonetta, Regolisti, Giuseppe, Rebora, Paola, Occhino, Giuseppe, Belli, Michele, Molon, Giulio, Citerio, Giuseppe, Beltrame, Anna, Maloberti, Alessandro, Generali, Elena, Giannattasio, Cristina, Epis, Oscar Massimiliano, Rossetti, Claudio, Bellelli, Giuseppe, De Nalda, Ana Lleo, Capua, Ilaria, Valsecchi, Maria Grazia, Genovesi, S, Regolisti, G, Rebora, P, Occhino, G, Belli, M, Molon, G, Citerio, G, Beltrame, A, Maloberti, A, Generali, E, Giannattasio, C, Epis, O, Rossetti, C, Bellelli, G, De Nalda, A, Capua, I, Valsecchi, M, Genovesi, Simonetta, Regolisti, Giuseppe, Rebora, Paola, Occhino, Giuseppe, Belli, Michele, Molon, Giulio, Citerio, Giuseppe, Beltrame, Anna, Maloberti, Alessandro, Generali, Elena, Giannattasio, Cristina, Epis, Oscar Massimiliano, Rossetti, Claudio, Bellelli, Giuseppe, De Nalda, Ana Lleo, Capua, Ilaria, and Valsecchi, Maria Grazia

Abstract

Background: The prognostic impact of electrolyte disorders in hospitalized COVID-19 patients is unclear. Methods: The study included all adult patients hospitalized for COVID-19 in four hospitals in Northern Italy between January 2020 and May 2021 with at least one serum potassium and sodium measurement performed within 3 days since admission. Primary outcome was in-hospital death; secondary outcome was Intensive Care Unit (ICU) admission. A cause-specific Cox proportional-hazards regression model was used for investigating the association between potassium and sodium (as either categorical or continuous variables) and mortality or admission to ICU. Results: Analyses included 3,418 adult hospitalized COVID-19 patients. At multivariable analysis, both hyperkalemia (Hazard Ratio, [HR] 1.833, 95% Confidence Interval [CI] 1.371–2.450) and sK above the median (K 5.1 vs 4.1 mmol/L: HR 1.523, 95% CI 1.295–1.798), and hypernatremia (HR 2.313, 95%CI 1.772–3.018) and sNa above the median (Na 149 vs 139 mmol/L: HR 1.442, 95% CI 1.234–1.686), were associated with in-hospital death, whereas hypokalemia and hyponatremia were not. Hyponatremia was associated with increased hazard of ICU admission (HR 1.884, 95%CI 1.389–2.556). Conclusions: Electrolyte disorders detected at hospital admission may allow early identification of COVID-19 patients at increased risk of adverse outcomes.

Published
2023

6. Long-term safety and efficacy of left atrial appendage occlusion in dialysis patients with atrial fibrillation: a multi-center, prospective, open label, observational study

Author

Genovesi, S, Porcu, L, Rebora, P, Slaviero, G, Casu, G, Bertoli, S, Airoldi, F, Buskermolen, M, Gallieni, M, Pieruzzi, F, Rovaris, G, Montoli, A, Piccaluga, E, Molon, G, Alberici, F, Adamo, M, Gaspardone, A, D'Angelo, G, Merella, P, Vezzoli, G, Trezzi, B, Mazzone, P, Genovesi, S, Porcu, L, Rebora, P, Slaviero, G, Casu, G, Bertoli, S, Airoldi, F, Buskermolen, M, Gallieni, M, Pieruzzi, F, Rovaris, G, Montoli, A, Piccaluga, E, Molon, G, Alberici, F, Adamo, M, Gaspardone, A, D'Angelo, G, Merella, P, Vezzoli, G, Trezzi, B, and Mazzone, P

Abstract

As children transition to adulthood, do they remain a major determinant of parental labor supply? To answer this question, we examine how college costs affect the labor supply of mothers and fathers by exploiting the roll-out of nine generous state merit aid programs in the United States from 1993 to 2004, which made college more affordable. Mothers of college-age children decreased their annual hours of work after the introduction of these state-wide programs, while fathers did not adjust their labor supply. Mothers of college-going children were entirely responsible for the decline in hours of work, where mothers of children who did not go to college experienced no change in hours of work. The decline in labor supply was mainly due to adjustments among high-income, married, more educated, and white mothers, whose labor supply was more elastic to college costs.

Published
2023

7. Feasibility of using smartphone app technology in the remote management of heart failure patients with cardiac implantable electronic devices

Author

Ziacchi, M, primary, Biffi, M, additional, Mauro, E, additional, Molon, G, additional, Costa, A, additional, Dell' Aquila, A, additional, Viscardi, L, additional, Botto, G, additional, Casale, M C, additional, Viscusi, M, additional, Brasca, F, additional, Santoro, A, additional, Curcio, A, additional, Manzo, M, additional, and Boriani, G, additional

Published
2023
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8. Comparative effectiveness and safety of non-vitamin K antagonists for atrial fibrillation in clinical practice:: GLORIA-AF Registry

Author

Lip G. Y. H., Kotalczyk A., Teutsch C., Diener H. -C., Dubner S. J., Halperin J. L., Ma C. -S., Rothman K. J., Marler S., Gurusamy V. K., Huisman M. V., Abban D. W., Aziz E., Kalan M. B., Abdul N., Backes L. M., Bradman D., Abud A. M., Badings E., Brautigam D., Adams F., Bagni E., Breton N., Addala S., Baker S. H., Brouwers P. J. A. M., Adragao P., Bala R., Browne K., Ageno W., Baldi A., Cortada J. B., Aggarwal R., Bando S., Bruni A., Agosti S., Banerjee S., Brunschwig C., Agostoni P., Bank A., Buathier H., Aguilar F., Esquivias G. B., Buhl A., Linares J. A., Barr C., Bullinga J., Aguinaga L., Bartlett M., Cabrera J. W., Ahmed J., Basic Kes V., Caccavo A., Aiello A., Baula G., Cai S., Ainsworth P., Behrens S., Caine S., Aiub J. R., Bell A., Calo L., Al-Dallow R., Benedetti R., Calvi V., Alderson L., Mazuecos J. B., Sanchez M. C., Velasco J. A. A., Benhalima B., Candeias R., Alexopoulos D., Bergler-Klein J., Capuano V., Manterola F. A., Berneau J. -B., Capucci A., Aliyar P., Bernstein R. A., Caputo R., Alonso D., Berrospi P., Rizo T. C., da Costa F. A. A., Berti S., Cardona F., Amado J., Berz A., da Costa Darrieux F. C., Amara W., Best E., Vera Y. C. D., Amelot M., Bettencourt P., Carolei A., Amjadi N., Betzu R., Carreno S., Ammirati F., Bhagwat R., Carvalho P., Andrade M., Bhatta L., Cary S., Andrawis N., Biscione F., Casu G., Annoni G., Bisignani G., Cavallini C., Ansalone G., Black T., Cayla G., Ariani M. K., Bloch M. J., Celentano A., Arias J. C., Bloom S., Cha T. -J., Armero S., Blumberg E., Cha K. S., Arora C., Bo M., Chae J. K., Aslam M. S., Bohmer E., Chalamidas K., Asselman M., Bollmann A., Challappa K., Audouin P., Bongiorni M. G., Chand S. P., Augenbraun C., Boriani G., Chandrashekar H., Aydin S., Boswijk D. J., Chartier L., Bott J., Chatterjee K., Ayryanova I., Bottacchi E., Ayala C. A. C., Cheema A., Davis G., Evonich R., Davy J. -M., Evseeva O., Chen L., Dayer M., Ezhov A., Chen S. -A., De Biasio M., Fahmy R., Chen J. H., De Bonis S., Fang Q., Chiang F. -T., De Caterina R., Farsad R., Chiarella F., De Franceschi T., Fauchier L., Chih-Chan L., de Groot J. R., Favale S., Cho Y. K., De Horta J., Fayard M., Choi J. -I., De La Briolle A., Fedele J. L., Choi D. J., de la Pena Topete G., Fedele F., Chouinard G., de Paola A. A. V., Fedorishina O., Chow D. H. -F., de Souza W., Fera S. R., Chrysos D., de Veer A., Ferreira L. G. G., Chumakova G., De Wolf L., Ferreira J., Valenzuela E. J. J. R. C., Decoulx E., Ferri C., Nica N. C., Deepak S., Ferrier A., Cislowski D. J., Defaye P., Ferro H., Clay A., Munoz F. D. -C., Finsen A., Clifford P., Brkljacic D. D., First B., Cohen A., Deumite N. J., Fischer S., Cohen M., Di Legge S., Fonseca C., Cohen S., Diemberger I., Almeida L. F., Colivicchi F., Dietz D., Forman S., Collins R., Dionisio P., Frandsen B., Colonna P., Dong Q., French W., Compton S., dos Santos F. R., Friedman K., Connolly D., Dotcheva E., Friese A., Conti A., Doukky R., Fruntelata A. G., Buenostro G. C., D'Souza A., Fujii S., Coodley G., Dubrey S., Fumagalli S., Cooper M., Ducrocq X., Fundamenski M., Coronel J., Dupljakov D., Furukawa Y., Corso G., Duque M., Gabelmann M., Sales J. C., Dutta D., Gabra N., Cottin Y., Duvilla N., Gadsboll N., Covalesky J., Duygun A., Galinier M., Cracan A., Dziewas R., Gammelgaard A., Crea F., Eaton C. B., Ganeshkumar P., Crean P., Eaves W., Gans C., Crenshaw J., Ebels-Tuinbeek L. A., Quintana A. G., Cullen T., Ehrlich C., Gartenlaub O., Darius H., Eichinger-Hasenauer S., Gaspardone A., Dary P., Eisenberg S. J., Genz C., Dascotte O., Jabali A. E., Georger F., Dauber I., Shahawy M. E., Georges J. -L., Davalos V., Hernandes M. E., Georgeson S., Davies R., Izal A. E., Giedrimas E., Gierba M., Haruna T., Jarmukli N., Ortega I. G., Hayek E., Jeanfreau R. J., Gillespie E., Healey J., Jenkins R. D., Giniger A., Hearne S., Sanchez C. J., Giudici M. C., Heffernan M., Jimenez J., Gkotsis A., Heggelund G., Jobe R., Glotzer T. V., Heijmeriks J. A., Joen-Jakobsen T., Gmehling J., Hemels M., Jones N., Gniot J., Hendriks I., Jorge J. C. M., Goethals P., Henein S., Jouve B., Goldbarg S., Her S. -H., Jung B. C., Goldberg R., Hermany P., Jung K. T., Goldmann B., Del Rio J. E. H., Jung W., Golitsyn S., Higashino Y., Kachkovskiy M., Gomez S., Hill M., Kafkala K., Mesa J. G., Hisadome T., Kalinina L., Gonzalez V. B., Hishida E., Kallmunzer B., Hermosillo J. A. G., Hoffer E., Kamali F., Lopez V. M. G., Hoghton M., Kamo T., Gorka H., Hong K., Kampus P., Gornick C., Hong S., Kashou H., Gorog D., Horbach S., Kastrup A., Gottipaty V., Horiuchi M., Katsivas A., Goube P., Hou Y., Kaufman E., Goudevenos I., Hsing J., Kawai K., Graham B., Huang C. -H., Kawajiri K., Greer G. S., Huckins D., Kazmierski J. F., Gremmler U., Hughes K., Keeling P., Grena P. G., Huizinga A., Saraiva J. F. K., Grond M., Hulsman E. L., Ketova G., Gronda E., Hung K. -C., Khaira A. S., Gronefeld G., Hwang G. -S., Khripun A., Gu X., Ikpoh M., Kim D. -I., Torres I. G. T., Imberti D., Kim Y. H., Guardigli G., Ince H., Kim N. H., Guevara C., Indolfi C., Kim D. K., Guignier A., Inoue S., Kim J. S., Gulizia M., Irles D., Gumbley M., Iseki H., Kim K. S., Gunther A., Israel C. N., Kim J., Ha A., Iteld B., Kinova E., Hahalis G., Iyer V., Klein A., Hakas J., Jackson-Voyzey E., Kmetzo J. J., Hall C., Jaffrani N., Kneller G. L., Han B., Jager F., Knezevic A., Han S., James M., Koh S. M. A., Hargrove J., Jang S. -W., Koide S., Hargroves D., Jaramillo N., Kollias A., Kooistra J. A., Li W., McClure J., Koons J., Li X., McCormack T., Koschutnik M., Lichy C., McGarity W., Kostis W. J., Lieber I., McIntyre H., Kovacic D., Rodriguez R. H. L., McLaurin B., Kowalczyk J., Lin H., Alvaro F., Palomino M., Koziolova N., Melandri F., Kraft P., Liu F., Meno H., Kragten J. A., Liu H., Menzies D., Krantz M., Esperon G. L., Mercader M., Krause L., Navarro N. L., Meyer C., Krenning B. J., Lo E., Meyer B. J., Krikke F., Lokshyn S., Miarka J., Kromhout Z., Lopez A., Mibach F., Krysiak W., Lopez-Sendon J. L., Michalski D., Kumar P., Filho A. M. L., Michel P., Kumler T., Lorraine R. S., Chreih R. M., Kuniss M., Luengas C. A., Luengas A., Mikdadi G., Kuo J. -Y., Luke R., Mikus M., Kuppers A., Luo M., Milicic D., Kurrelmeyer K., Lupovitch S., Militaru C., Kwak C. H., Lyrer P., Minaie S., Laboulle B., Ma C., Minescu B., Labovitz A., Ma G., Mintale I., Ter Lai W., Madariaga I., Mirault T., Lam A., Maeno K., Mirro M. J., Lam Y. Y., Magnin D., Mistry D., Lanas Zanetti F., Maid G., Miu N. V., Landau C., Mainigi S. K., Miyamoto N., Landini G., Makaritsis K., Moccetti T., Lanna Figueiredo E., Malhotra R., Mohammed A., Larsen T., Manning R., Nor A. M., Lavandier K., Manolis A., Mollerus M., LeBlanc J., Hurtado H. A. M., Molon G., Lee M. H., Mantas I., Mondillo S., Lee C. -H., Jattin F. M., Moniz P., Lehman J., Maqueda V., Mont L., Leitao A., Marchionni N., Montagud V., Lellouche N., Ortuno F. M., Montana O., Lelonek M., Santana A. M., Monti C., Lenarczyk R., Martinez J., Moretti L., Lenderink T., Maskova P., Mori K., Gonzalez S. L., Hernandez N. M., Moriarty A., Leong-Sit P., Matsuda K., Morka J., Leschke M., Maurer T., Moschini L., Ley N., Mauro C., Moschos N., Li Z., May E., Mugge A., Mayer N., Mulhearn T. J., Muresan C., Jose E. P., Precoma D. B., Muriago M., Padilla F. G. P., Prelle A., Musial W., Rios V. P., Prodafikas J., Musser C. W., Pajes G., Protasov K., Musumeci F., Pandey A. S., Pye M., Nageh T., Paparella G., Qiu Z., Nakagawa H., Paris F., Quedillac J. -M., Nakamura Y., Park H. W., Raev D., Nakayama T., Park J. S., Grado C. A. R., Nam G. -B., Parthenakis F., Rahimi S., Nanna M., Passamonti E., Raisaro A., Natarajan I., Patel R. J., Rama B., Nayak H. M., Patel J., Ramos R., Naydenov S., Patel M., Ranieri M., Nazlic J., Patrick J., Raposo N., Nechita A. C., Jimenez R. P., Rashba E., Nechvatal L., Paz A., Rauch-Kroehnert U., Negron S. A., Pengo V., Reddy R., Neiman J., Pentz W., Renda G., Neuenschwander F. C., Perez B., Reza S., Neves D., Rios A. M. P., Ria L., Neykova A., Perez-Cabezas A., Richter D., Miguel R. N., Perlman R., Rickli H., Nijmeh G., Persic V., Rieker W., Nizov A., Perticone F., Vera T. R., Campos R. N., Peters T. K., Ritt L. E., Nossan J., Petkar S., Roberts D., Novikova T., Pezo L. F., Briones I. R., Nowalany-Kozielska E., Pflucke C., Escudero A. E. R., Nsah E., Pham D. N., Pascual C. R., Fragoso J. C. N., Phillips R. T., Roman M., Nurgalieva S., Phlaum S., Romeo F., Nuyens D., Pieters D., Ronner E., Nyvad O., Pineau J., Roux J. -F., de Los Rios Ibarra M. O., Pinter A., Rozkova N., O'Donnell P., Pinto F., Rubacek M., O'Donnell M., Pisters R., Rubalcava F., Oh S., Pivac N., Russo A. M., Oh Y. S., Pocanic D., Rutgers M. P., Oh D., Podoleanu C., Rybak K., O'Hara G., Politano A., Said S., Oikonomou K., Poljakovic Z., Sakamoto T., Olivares C., Pollock S., Salacata A., Oliver R., Garcea J. P., Salem A., Ruiz R. O., Poppert H., Bodes R. S., Olympios C., Porcu M., Saltzman M. A., Omaszuk-Kazberuk A., Reino A. P., Salvioni A., Asensi J. O., Prasad N., Vallejo G. S., Fernandez M. S., Sokal A., Tu T. M., Saporito W. F., Yan Y. S. O., Tuininga Y., Sarikonda K., Sotolongo R., Turakhia M., Sasaoka T., de Souza O. F., Turk S., Sati H., Sparby J. A., Turner W., Savelieva I., Spinar J., Tveit A., Scala P. -J., Sprigings D., Tytus R., Schellinger P., Spyropoulos A. C., Valadao C., Scherr C., Stakos D., van Bergen P. F. M. M., Schmitz L., Steinwender C., van de Borne P., Schmitz K. -H., Stergiou G., van den Berg B. J., Schmitz B., Stiell I., van der Zwaan C., Schnabel T., Stoddard M., Van Eck M., Schnupp S., Stoikov A., Vanacker P., Schoeniger P., Streb W., Vasilev D., Schon N., Styliadis I., Vasilikos V., Schwimmbeck P., Su G., Vasilyev M., Seamark C., Su X., Veerareddy S., Searles G., Sudnik W., Mino M. V., Seidl K. -H., Sukles K., Venkataraman A., Seidman B., Sun X., Verdecchia P., Sek J., Swart H., Versaci F., Sekaran L., Szavits-Nossan J., Vester E. G., Serrati C., Taggeselle J., Vial H., Shah N., Takagi Y., Victory J., Shah V., Takhar A. P. S., Villamil A., Shah A., Tamm A., Vincent M., Shah S., Tanaka K., Vlastaris A., Sharma V. K., Tanawuttiwat T., Dahl J., Shaw L., Tang S., Vora K., Sheikh K. H., Tang A., Vranian R. B., Shimizu N., Tarsi G., Wakefield P., Shimomura H., Tassinari T., Wang N., Shin D. -G., Tayal A., Wang M., Shin E. -S., Tayebjee M., Wang X., Shite J., Berg J. M., Wang F., Sibilio G., Tesloianu D., Wang T., Silver F., The S. H. K., Warner A. L., Sime I., Thomas D., Watanabe K., Simmers T. A., Timsit S., Wei J., Singh N., Tobaru T., Weimar C., Siostrzonek P., Tomasik A. R., Weiner S., Smadja D., Torosoff M., Weinrich R., Smith D. W., Touze E., Wen M. -S., Snitman M., Trendafilova E., Wiemer M., Filho D. S., Tsai W. K., Wiggers P., Soda H., Tse H. F., Wilke A., Sofley C., Tsutsui H., Williams D., Williams M. L., Yan P. Y. B., Zhang P., Witzenbichler B., Yang T., Zhang J., Wong B., Yao J., Zhao S. P., Wong K. S. L., Yeh K. -H., Zhao Y., Wozakowska-Kaplon B., Yin W. H., Zhao Z., Wu S., Yotov Y., Zheng Y., Wu R. C., Zahn R., Zhou J., Wunderlich S., Zarich S., Zimmermann S., Wyatt N., Zenin S., Zini A., Wylie J., Zeuthen E. L., Zizzo S., Xu Y., Zhang H., Zong W., Xu X., Zhang D., Zukerman L. 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Vora K., Sheikh K.H., Tang A., Vranian R.B., Shimizu N., Tarsi G., Wakefield P., Shimomura H., Tassinari T., Wang N., Shin D.-G., Tayal A., Wang M., Shin E.-S., Tayebjee M., Wang X., Shite J., Berg J.M., Wang F., Sibilio G., Tesloianu D., Wang T., Silver F., The S.H.K., Warner A.L., Sime I., Thomas D., Watanabe K., Simmers T.A., Timsit S., Wei J., Singh N., Tobaru T., Weimar C., Siostrzonek P., Tomasik A.R., Weiner S., Smadja D., Torosoff M., Weinrich R., Smith D.W., Touze E., Wen M.-S., Snitman M., Trendafilova E., Wiemer M., Filho D.S., Tsai W.K., Wiggers P., Soda H., Tse H.F., Wilke A., Sofley C., Tsutsui H., Williams D., Williams M.L., Yan P.Y.B., Zhang P., Witzenbichler B., Yang T., Zhang J., Wong B., Yao J., Zhao S.P., Wong K.S.L., Yeh K.-H., Zhao Y., Wozakowska-Kaplon B., Yin W.H., Zhao Z., Wu S., Yotov Y., Zheng Y., Wu R.C., Zahn R., Zhou J., Wunderlich S., Zarich S., Zimmermann S., Wyatt N., Zenin S., Zini A., Wylie J., Zeuthen E.L., Zizzo S., Xu Y., Zhang H., Zong W., Xu X., Zhang D., Zukerman L.S., Yamanoue H., Zhang X., and Yamashita T.

Subjects
Apixaban, Atrial fibrillation, Dabigatran, Non-vitamin K antagonists, Rivaroxaban, Pyridones, Medizin, Myocardial Infarction, Administration, Oral, Anticoagulants, Hemorrhage, General Medicine, Non-vitamin K antagonist, Stroke, Clinical Trials, Phase III as Topic, Humans, Prospective Studies, Registries, Cardiology and Cardiovascular Medicine
Abstract

Background and purpose Prospectively collected data comparing the safety and effectiveness of individual non-vitamin K antagonists (NOACs) are lacking. Our objective was to directly compare the effectiveness and safety of NOACs in patients with newly diagnosed atrial fibrillation (AF). Methods In GLORIA-AF, a large, prospective, global registry program, consecutive patients with newly diagnosed AF were followed for 3 years. The comparative analyses for (1) dabigatran vs rivaroxaban or apixaban and (2) rivaroxaban vs apixaban were performed on propensity score (PS)-matched patient sets. Proportional hazards regression was used to estimate hazard ratios (HRs) for outcomes of interest. Results The GLORIA-AF Phase III registry enrolled 21,300 patients between January 2014 and December 2016. Of these, 3839 were prescribed dabigatran, 4015 rivaroxaban and 4505 apixaban, with median ages of 71.0, 71.0, and 73.0 years, respectively. In the PS-matched set, the adjusted HRs and 95% confidence intervals (CIs) for dabigatran vs rivaroxaban were, for stroke: 1.27 (0.79–2.03), major bleeding 0.59 (0.40–0.88), myocardial infarction 0.68 (0.40–1.16), and all-cause death 0.86 (0.67–1.10). For the comparison of dabigatran vs apixaban, in the PS-matched set, the adjusted HRs were, for stroke 1.16 (0.76–1.78), myocardial infarction 0.84 (0.48–1.46), major bleeding 0.98 (0.63–1.52) and all-cause death 1.01 (0.79–1.29). For the comparison of rivaroxaban vs apixaban, in the PS-matched set, the adjusted HRs were, for stroke 0.78 (0.52–1.19), myocardial infarction 0.96 (0.63–1.45), major bleeding 1.54 (1.14–2.08), and all-cause death 0.97 (0.80–1.19). Conclusions Patients treated with dabigatran had a 41% lower risk of major bleeding compared with rivaroxaban, but similar risks of stroke, MI, and death. Relative to apixaban, patients treated with dabigatran had similar risks of stroke, major bleeding, MI, and death. Rivaroxaban relative to apixaban had increased risk for major bleeding, but similar risks for stroke, MI, and death. Registration URL: https://www.clinicaltrials.gov. Unique identifiers: NCT01468701, NCT01671007. Date of registration: September 2013. Graphical abstract

Published
2022
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9. Outcomes on safety and efficacy of left atrial appendage occlusion in end stage renal disease patients undergoing dialysis

Author

Genovesi, S, Porcu, L, Slaviero, G, Casu, G, Bertoli, S, Sagone, A, Buskermolen, M, Pieruzzi, F, Rovaris, G, Montoli, A, Oreglia, J, Piccaluga, E, Molon, G, Gaggiotti, M, Ettori, F, Gaspardone, A, Palumbo, R, Viazzi, F, Breschi, M, Gallieni, M, Contaldo, G, D'Angelo, G, Merella, P, Galli, F, Rebora, P, Valsecchi, M, Mazzone, P, Genovesi S., Porcu L., Slaviero G., Casu G., Bertoli S., Sagone A., Buskermolen M., Pieruzzi F., Rovaris G., Montoli A., Oreglia J., Piccaluga E., Molon G., Gaggiotti M., Ettori F., Gaspardone A., Palumbo R., Viazzi F., Breschi M., Gallieni M., Contaldo G., D'Angelo G., Merella P., Galli F., Rebora P., Valsecchi M., Mazzone P., Genovesi, S, Porcu, L, Slaviero, G, Casu, G, Bertoli, S, Sagone, A, Buskermolen, M, Pieruzzi, F, Rovaris, G, Montoli, A, Oreglia, J, Piccaluga, E, Molon, G, Gaggiotti, M, Ettori, F, Gaspardone, A, Palumbo, R, Viazzi, F, Breschi, M, Gallieni, M, Contaldo, G, D'Angelo, G, Merella, P, Galli, F, Rebora, P, Valsecchi, M, Mazzone, P, Genovesi S., Porcu L., Slaviero G., Casu G., Bertoli S., Sagone A., Buskermolen M., Pieruzzi F., Rovaris G., Montoli A., Oreglia J., Piccaluga E., Molon G., Gaggiotti M., Ettori F., Gaspardone A., Palumbo R., Viazzi F., Breschi M., Gallieni M., Contaldo G., D'Angelo G., Merella P., Galli F., Rebora P., Valsecchi M., and Mazzone P.

Abstract

Background: In patients with end stage renal disease and atrial fibrillation (AF), undergoing chronic dialysis, direct oral agents are contraindicated and warfarin does not fully prevent embolic events while increasing the bleeding risk. The high hemorrhagic risk represents the main problem in this population. Aim of the study was to estimate the safety and efficacy for thromboembolic prevention of left atrial appendage (LAA) occlusion in a cohort of dialysis patients with AF and high hemorrhagic risk. Methods: Ninety-two dialysis patients with AF who underwent LAA occlusion were recruited. For comparative purposes, two cohorts of dialysis patients with AF, one taking warfarin (oral anticoagulant therapy, OAT cohort, n = 114) and the other not taking any OAT (no-therapy cohort, n = 148) were included in the study. Primary endpoints were (1) incidence of peri-procedural complications, (2) incidence of 2-year thromboembolic and hemorrhagic events, (3) mortality at 2 years. In order to evaluate the effect of the LAA occlusion on the endpoints with respect to the OAT and No-therapy cohorts, a multivariable Cox regression model was applied adjusted for possible confounding factors. Results: The device was successfully implanted in 100% of cases. Two major peri-procedural complications were reported. No thromboembolic events occurred at 2-year follow-up. The adjusted multivariable Cox regression model showed no difference in bleeding risk in the OAT compared to the LAA occlusion cohort in the first 3 months of follow-up [HR 1.65 (95% CI 0.43–6.33)], when most of patients were taking two antiplatelet drugs. In the following 21 months the bleeding incidence became higher in OAT patients [HR 6.48 (95% CI 1.32–31.72)]. Overall mortality was greater in both the OAT [HR 2.76 (95% CI 1.31–5.86)] and No-Therapy [HR 3.09 (95% CI 1.59–5.98)] cohorts compared to LAA occlusion patients. Conclusions: The study could open the way to a non-pharmacological option for

Published
2021

10. Correction to: Outcomes on safety and efficacy of left atrial appendage occlusion in end stage renal disease patients undergoing dialysis (Journal of Nephrology, (2020), 10.1007/s40620-020-00774-5)

Author

Genovesi S., Genovesi, S, Porcu, L, Slaviero, G, Casu, G, Bertoli, S, Sagone, A, Buskermolen, M, Pieruzzi, F, Rovaris, G, Montoli, A, Oreglia, J, Piccaluga, E, Molon, G, Gaggiotti, M, Ettori, F, Gaspardone, A, Palumbo, R, Viazzi, F, Breschi, M, Gallieni, M, Contaldo, G, D'Angelo, G, Merella, P, Galli, F, Rebora, P, Valsecchi, M, Mazzone, P, Genovesi S., Porcu L., Slaviero G., Casu G., Bertoli S., Sagone A., Buskermolen M., Pieruzzi F., Rovaris G., Montoli A., Oreglia J., Piccaluga E., Molon G., Gaggiotti M., Ettori F., Gaspardone A., Palumbo R., Viazzi F., Breschi M., Gallieni M., Contaldo G., D'Angelo G., Merella P., Galli F., Rebora P., Valsecchi M., Mazzone P., Genovesi S., Genovesi, S, Porcu, L, Slaviero, G, Casu, G, Bertoli, S, Sagone, A, Buskermolen, M, Pieruzzi, F, Rovaris, G, Montoli, A, Oreglia, J, Piccaluga, E, Molon, G, Gaggiotti, M, Ettori, F, Gaspardone, A, Palumbo, R, Viazzi, F, Breschi, M, Gallieni, M, Contaldo, G, D'Angelo, G, Merella, P, Galli, F, Rebora, P, Valsecchi, M, Mazzone, P, Genovesi S., Porcu L., Slaviero G., Casu G., Bertoli S., Sagone A., Buskermolen M., Pieruzzi F., Rovaris G., Montoli A., Oreglia J., Piccaluga E., Molon G., Gaggiotti M., Ettori F., Gaspardone A., Palumbo R., Viazzi F., Breschi M., Gallieni M., Contaldo G., D'Angelo G., Merella P., Galli F., Rebora P., Valsecchi M., and Mazzone P.

Abstract

The article Outcomes on safety and efficacy of left atrial appendage occlusion in end stage renal disease patients undergoing dialysis, written by Simonetta Genovesi, Luca Porcu, Giorgio Slaviero, Gavino Casu, Silvio Bertoli, Antonio Sagone, Monique Buskermolen, Federico Pieruzzi, Giovanni Rovaris, Alberto Montoli, Jacopo Oreglia, Emanuela Piccaluga, Giulio Molon, Mario Gaggiotti, Federica Ettori, Achille Gaspardone, Roberto Palumbo, Francesca Viazzi, Marco Breschi, Maurizio Gallieni, Gina Contaldo, Giuseppe D’Angelo, Pierluigi Merella, Fabio Galli, Paola Rebora, Mariagrazia Valsecchi, and Patrizio Mazzone, was originally published electronically on the publisher’s internet portal on 6 June 2020 without open access. With the author(s)’ decision to opt for Open Choice the copyright of the article changed on 10 July 2020 to © The Author(s) 2020 and this article is licensed under a Creative Commons Attribution 4.0 International License (http://creat iveco mmons .org/licen ses/ by/4.0/), which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The original article has been updated.

Published
2021

11. Atrial fibrillation incidence in SARS-CoV-2 infected patients: predictors and relationship with in-hospital mortality

Author

Maloberti, A, primary, Giannattasio, C, additional, Rebora, P, additional, Occhino, G, additional, Ughi, N, additional, Fabbri, S, additional, Cartella, I, additional, Algeri, M, additional, Scarpellini, S, additional, Rossetti, C, additional, Epis, O M, additional, Molon, G, additional, Bonfanti, P, additional, Valsecchi, M G, additional, and Genovesi, S, additional

Published
2022
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13. Incident Atrial Fibrillation and In-Hospital Mortality in SARS-CoV-2 Patients

Author

Maloberti, A, Giannattasio, C, Rebora, P, Occhino, G, Ughi, N, Biolcati, M, Gualini, E, Rizzi, J, Algeri, M, Giani, V, Rossetti, C, Epis, O, Molon, G, Beltrame, A, Bonfanti, P, Valsecchi, M, Genovesi, S, Maloberti, Alessandro, Giannattasio, Cristina, Rebora, Paola, Occhino, Giuseppe, Ughi, Nicola, Biolcati, Marco, Gualini, Elena, Rizzi, Jacopo Giulio, Algeri, Michela, Giani, Valentina, Rossetti, Claudio, Epis, Oscar Massimiliano, Molon, Giulio, Beltrame, Anna, Bonfanti, Paolo, Valsecchi, Maria Grazia, Genovesi, Simonetta, Maloberti, A, Giannattasio, C, Rebora, P, Occhino, G, Ughi, N, Biolcati, M, Gualini, E, Rizzi, J, Algeri, M, Giani, V, Rossetti, C, Epis, O, Molon, G, Beltrame, A, Bonfanti, P, Valsecchi, M, Genovesi, S, Maloberti, Alessandro, Giannattasio, Cristina, Rebora, Paola, Occhino, Giuseppe, Ughi, Nicola, Biolcati, Marco, Gualini, Elena, Rizzi, Jacopo Giulio, Algeri, Michela, Giani, Valentina, Rossetti, Claudio, Epis, Oscar Massimiliano, Molon, Giulio, Beltrame, Anna, Bonfanti, Paolo, Valsecchi, Maria Grazia, and Genovesi, Simonetta

Abstract

Background: Among the different cardiovascular (CV) manifestations of the coronavirus disease 2019 (COVID-19), arrhythmia and atrial fibrillation (AF) in particular have recently received special attention. The aims of our study were to estimate the incidence of AF in patients hospitalized for COVID-19, and to evaluate its role as a possible predictor of in-hospital all-cause mortality. (2) Methods: We enrolled 3435 people with SARS-CoV2 infection admitted to three hospitals in Northern Italy from February 2020 to May 2021. We collected data on their clinical history, laboratory tests, pharmacological treatment and intensive care unit (ICU) admission. Incident AF and all-cause in-hospital mortality were considered as outcomes. (3) Results: 145 (4.2%) patients developed AF during hospitalization, with a median time since admission of 3 days (I-III quartile: 0, 12). Patients with incident AF were admitted more frequently to the ICU (39.3 vs. 12.4%, p < 0.001), and more frequently died (37.2 vs. 16.9%, p < 0.001). In the Cox regression model, the significant determinants of incident AF were age (HR: 1.041; 95% CI: 1.022, 1.060 per year), a history of AF (HR: 2.720; 95% CI: 1.508, 4.907), lymphocyte count (HR: 0.584; 95% CI: 0.384, 0.888 per 103/µL), estimated glomerular filtration rate (eGFR, HR: 0.988; 95% CI: 0.980, 0.996 per mL/min) and ICU admission (HR: 5.311; 95% CI: 3.397, 8.302). Incident AF was a predictor of all-cause mortality (HR: 1.405; 95% CI: 1.027, 1.992) along with age (HR: 1.057; 95% CI: 1.047, 1.067), male gender (HR: 1.315; 95% CI: 1.064; 1.626), dementia (HR: 1.373; 95% CI: 1.045, 1.803), lower platelet (HR: 0.997; 95% CI: 0.996, 0.998 per 103/µL) and lymphocyte counts (HR: 0.843; 95% CI: 0.725, 0.982 per 103/µL), C-Reactive protein values (HR: 1.004; 95% CI: 1.003, 1.005 per mg/L), eGFR (HR: 0.990; 95% CI: 0.986, 0.994 per mL/min), and ICU admission (HR: 1.759; 95% CI: 1.292, 2.395). (4) Conclusions: Incident AF is a common complication in C

Published
2022

14. Atrial Fibrillation Incidence in SARS-COV-2 Infected Patients: Predictors and Relationship with in-Hospital Mortality

Author

Maloberti, A, Giannattasio, C, Rebora, P, Occhino, G, Ughi, N, Rizzo, J, Fabbri, S, Leidi, F, Cartella, I, Algeri, M, Scarpellini, S, Rossetti, C, Epis, O, Molon, G, Bonfanti, P, Valsecchi, M, Genovesi, S, Maloberti, Alessandro, Giannattasio, Cristina, Rebora, Paola, Occhino, Giuseppe, Ughi, Nicola, Rizzo, Jacopo, Fabbri, Saverio, Leidi, Filippo, Cartella, Iside, Algeri, Michela, Scarpellini, Sara, Rossetti, Claudio, Epis, Oscar, Molon, Giulio, Bonfanti, Paolo, Valsecchi, Maria Grazia, Genovesi, Simonetta, Maloberti, A, Giannattasio, C, Rebora, P, Occhino, G, Ughi, N, Rizzo, J, Fabbri, S, Leidi, F, Cartella, I, Algeri, M, Scarpellini, S, Rossetti, C, Epis, O, Molon, G, Bonfanti, P, Valsecchi, M, Genovesi, S, Maloberti, Alessandro, Giannattasio, Cristina, Rebora, Paola, Occhino, Giuseppe, Ughi, Nicola, Rizzo, Jacopo, Fabbri, Saverio, Leidi, Filippo, Cartella, Iside, Algeri, Michela, Scarpellini, Sara, Rossetti, Claudio, Epis, Oscar, Molon, Giulio, Bonfanti, Paolo, Valsecchi, Maria Grazia, and Genovesi, Simonetta

Abstract

Among the different CardioVascular (CV) manifestation of the COronaVIrus-related Disease (COVID) particular attention has been paid to arrhythmia and particularly to Atrial fibrillation (AF). The aim of our study was to assess the incidence of AF episodes in patients ospitalisat for COVID and to evaluate its predictors and its relationship with in-hospital all-cause mortality.

Published
2022

16. PO-1452 Stereotactic ablative radiotherapy in patients with refractory ventricular tachyarrhythmia

Author

Nicosia, L., primary, Giaj-Levra, N., additional, Sicignano, G., additional, Cuccia, F., additional, Figlia, V., additional, Mazzola, R., additional, Ricchetti, F., additional, Rigo, M., additional, Vitale, C., additional, Attinà, G., additional, De Simone, A., additional, Gurrera, D., additional, Ruggeri, R., additional, Molon, G., additional, and Alongi, F., additional

Published
2022
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17. P16 ATRIAL FIBRILLATION INCIDENCE IN SARS–COV–2 INFECTED PATIENTS: PREDICTORS AND RELATIONSHIP WITH IN–HOSPITAL MORTALITY

Author

Maloberti, A, primary, Giannattasio, C, additional, Rebora, P, additional, Occhino, G, additional, Ughi, N, additional, Rizzo, J, additional, Fabbri, S, additional, Leidi, F, additional, Cartella, I, additional, Algeri, M, additional, Scarpellini, S, additional, Rossetti, C, additional, Epis, O, additional, Molon, G, additional, Bonfanti, P, additional, Valsecchi, M, additional, and Genovesi, S, additional

Published
2022
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19. Role of CHA₂DS₂-VASc score in predicting atrial fibrillation recurrence in patients undergoing pulmonary vein isolation with cryoballoon ablation [Role of CHA(2)DS(2)-VASc score in predicting atrial fibrillation recurrence in patients undergoing pulmonary vein isolation with cryoballoon ablation]

Author

Rordorf, R., Iacopino, S., Verlato, R., Arena, G., Tondo, C., Molon, G., Manfrin, M., Rovaris, G., Perego, G.B., Sciarra, L., Mantica, M., Sacchi, R., and Pieragnoli, P.

Subjects
AF recurrences, CHA2DS2-VASc, Cryoballoon, Outcomes, Paroxysmal atrial fibrillation, Persistent atrial fibrillation, Settore MED/11 - Malattie dell'Apparato Cardiovascolare
Published
2022

20. Five waves of COVID-19 pandemic in Italy: results of a national survey evaluating the impact on activities related to arrhythmias, pacing, and electrophysiology promoted by AIAC (Italian Association of Arrhythmology and Cardiac Pacing)

Author

Boriani, G., Guerra, F., De Ponti, R., D'Onofrio, A., Accogli, M., Bertini, M., Bisignani, G., Forleo, G. B., Landolina, M., Lavalle, C., Notarstefano, P., Ricci, R. P., Zanotto, G., Palmisano, P., Luise, R., De Bonis, S., Pangallo, A., Talarico, A., Maglia, G., Aspromonte, V., Nigro, G., Bianchi, V., Rapacciuolo, A., Ammendola, E., Solimene, F., Stabile, G., Biffi, M., Ziacchi, M., Malpighi, P. S. O., Saporito, D., Casali, E., Turco, V., Malavasi, V. L., Vitolo, M., Imberti, J. F., Anna, A. S., Zardini, M., Placci, A., Quartieri, F., Bottoni, N., Carinci, V., Barbato, G., De Maria, E., Borghi, A., Ramazzini, O. B., Bronzetti, G., Tomasi, C., Boggian, G., Virzi, S., Sassone, B., Corzani, A., Sabbatani, P., Pastori, P., Ciccaglioni, A., Adamo, F., Scaccia, A., Spampinato, A., Patruno, N., Biscione, F., Cinti, C., Pignalberi, C., Calo, L., Tancredi, M., Di Belardino, N., Ricciardi, D., Cauti, F., Rossi, P., Cardinale, M., Ansalone, G., Narducci, M. L., Pelargonio, G., Silvetti, M., Drago, F., Santini, L., Pentimalli, F., Pepi, P., Caravati, F., Taravelli, E., Belotti, G., Rordorf, R., Mazzone, P., Bella, P. D., Rossi, S., Canevese, L. F., Cilloni, S., Doni, L. A., Vergara, P., Baroni, M., Perna, E., Gardini, A., Negro, R., Perego, G. B., Curnis, A., Arabia, G., Russo, A. D., Marchese, P., Dell'Era, G., Occhetta, E., Pizzetti, F., Amellone, C., Giammaria, M., Devecchi, C., Coppolino, A., Tommasi, S., Anselmino, M., Coluccia, G., Guido, A., Rillo, M., Palama, Z., Luzzi, G., Pellegrino, P. L., Grimaldi, M., Grandinetti, G., Vilei, E., Potenza, D., Scicchitano, P., Favale, S., Santobuono, V. E., Sai, R., Melissano, D., Candida, T. R., Bonfantino, V. M., Di Canda, D., Gianfrancesco, D., Carretta, D., Pisano, E. C. L., Medico, A., Giaccari, R., Aste, R., Murgia, C., Nissardi, V., Sanna, G. D., Firetto, G., Crea, P., Ciotta, E., Sgarito, G., Caramanno, G., Ciaramitaro, G., Faraci, A., Fasheri, A., Di Gregorio, L., Campsi, G., Muscio, G., Giannola, G., Padeletti, M., Del Rosso, A., Nesti, M., Miracapillo, G., Giovannini, T., Pieragnoli, P., Rauhe, W., Marini, M., Guarracini, F., Ridarelli, M., Fedeli, F., Mazza, A., Zingarini, G., Andreoli, C., Carreras, G., Zorzi, A., Rossillo, A., Ignatuk, B., Zerbo, F., Molon, G., Fantinel, M., Zanon, F., Marcantoni, L., Zadro, M., and Bevilacqua, M.

Subjects
Cardiac resynchronization therapy, Remote monitoring, Emergency Medicine, Internal Medicine, Ablation, Arrhythmia, Atrial fibrillation, COVID-19, Implantable cardioverter defibrillators, Pacemakers
Abstract

The subsequent waves of the COVID-19 pandemic in Italy had a major impact on cardiac care.A survey to evaluate the dynamic changes in arrhythmia care during the first five waves of COVID-19 in Italy (first: March-May 2020; second: October 2020-January 2021; third: February-May 2021; fourth: June-October 2021; fifth: November 2021-February 2022) was launched.A total of 127 physicians from arrhythmia centers (34% of Italian centers) took part in the survey. As compared to 2019, a reduction in 40% of elective pacemaker (PM), defibrillators (ICD), and cardiac resynchronization devices (CRT) implantations, with a 70% reduction for ablations, was reported during the first wave, with a progressive and gradual return to pre-pandemic volumes, generally during the third-fourth waves, slower for ablations. For emergency procedures (PM, ICD, CRT, and ablations), recovery from the initial 10% decline occurred in most cases during the second wave, with some variability. However, acute care for atrial fibrillation, electrical cardioversions, and evaluations for syncope showed a prolonged reduction of activity. The number of patients with devices which started remote monitoring increased by 40% during the first wave, but then the adoption of remote monitoring declined.The dramatic and profound derangement in arrhythmia management that characterized the first wave of the COVID-19 pandemic was followed by a progressive return to the volume of activities of the pre-pandemic periods, even if with different temporal dynamics and some heterogeneity. Remote monitoring was largely implemented during the first wave, but full implementation is needed.

Published
2022

27. Anticoagulant selection in relation to the SAMe-TT2R2 score in patients with atrial fibrillation: The GLORIA-AF registry

Author

Ntaios, G., Huisman, M. V., Diener, H. -C., Halperin, J. L., Teutsch, C., Marler, S., Gurusamy, V. K., Thompson, M., Lip, G. Y. H., Olshansky, B., Abban, D. W., Abdul, N., Abud, A. M., Adams, F., Addala, S., Adragao, P., Ageno, W., Aggarwal, R., Agosti, S., Agostoni, P., Aguilar, F., Linares, J. A., Aguinaga, L., Ahmed, J., Aiello, A., Ainsworth, P., Aiub, J. R., Al-Dallow, R., Alderson, L., Aldrete Velasco, J. A., Alexopoulos, D., Manterola, F. A., Aliyar, P., Alonso, D., Alves da Costa, F. A., Amado, J., Amara, W., Amelot, M., Amjadi, N., Ammirati, F., Andrade, M., Andrawis, N., Annoni, G., Ansalone, G., Ariani, M. K., Arias, J. C., Armero, S., Arora, C., Aslam, M. S., Asselman, M., Audouin, P., Augenbraun, C., Aydin, S., Ayryanova, I., Aziz, E., Backes, L. M., Badings, E., Bagni, E., Baker, S. H., Bala, R., Baldi, A., Bando, S., Banerjee, S., Bank, A., Esquivias, G. B., Barr, C., Bartlett, M., Kes, V. B., Baula, G., Behrens, S., Bell, A., Benedetti, R., Mazuecos, J. B., Benhalima, B., Bergler-Klein, J., Berneau, J. -B., Bernstein, R. A., Berrospi, P., Berti, S., Berz, A., Best, E., Bettencourt, P., Betzu, R., Bhagwat, R., Bhatta, L., Biscione, F., Bisignani, G., Black, T., Bloch, M. J., Bloom, S., Blumberg, E., Bo, M., Bohmer, E., Bollmann, A., Bongiorni, M. G., Boriani, G., Boswijk, D. J., Bott, J., Bottacchi, E., Kalan, M. B., Bradman, D., Brautigam, D., Breton, N., Brouwers, P. J. A. M., Browne, K., Cortada, J. B., Bruni, A., Brunschwig, C., Buathier, H., Buhl, A., Bullinga, J., Cabrera, J. W., Caccavo, A., Cai, S., Caine, S., Calo, L., Calvi, V., Sanchez, M. C., Candeias, R., Capuano, V., Capucci, A., Caputo, R., Rizo, T. C., Cardona, F., Carlos da Costa Darrieux, F., Duarte Vera, Y. C., Carolei, A., Carreno, S., Carvalho, P., Cary, S., Casu, G., Cavallini, C., Cayla, G., Celentano, A., Cha, T. -J., Cha, K. S., Chae, J. K., Chalamidas, K., Challappa, K., Chand, S. P., Chandrashekar, H., Chartier, L., Chatterjee, K., Chavez Ayala, C. A., Cheema, A., Chen, L., Chen, S. -A., Chen, J. H., Chiang, F. -T., Chiarella, F., Chih-Chan, L., Cho, Y. K., Choi, J. -I., Choi, D. J., Chouinard, G., Hoi-Fan Chow, D., Chrysos, D., Chumakova, G., Jose Roberto Chuquiure Valenzuela, E. J., Nica, N. C., Cislowski, D. J., Clay, A., Clifford, P., Cohen, A., Cohen, M., Cohen, S., Colivicchi, F., Collins, R., Colonna, P., Compton, S., Connolly, D., Conti, A., Buenostro, G. C., Coodley, G., Cooper, M., Coronel, J., Corso, G., Sales, J. C., Cottin, Y., Covalesky, J., Cracan, A., Crea, Filippo, Crean, P., Crenshaw, J., Cullen, T., Darius, H., Dary, P., Dascotte, O., Dauber, I., Davalos, V., Davies, R., Davis, G., Davy, J. -M., Dayer, M., De Biasio, M., De Bonis, S., De Caterina, R., De Franceschi, T., de Groot, J. R., De Horta, J., De La Briolle, A., Topete, G. D. L. P., Vicenzo de Paola, A. A., de Souza, W., de Veer, A., De Wolf, L., Decoulx, E., Deepak, S., Defaye, P., Del-Carpio Munoz, F., Brkljacic, D. D., Deumite, N. J., Di Legge, S., Diemberger, I., Dietz, D., Dionisio, P., Dong, Q., Rossi dos Santos, F., Dotcheva, E., Doukky, R., D'Souza, A., Dubrey, S., Ducrocq, X., Dupljakov, D., Duque, M., Dutta, D., Duvilla, N., Duygun, A., Dziewas, R., Eaton, C. B., Eaves, W., Ebels-Tuinbeek, L. A., Ehrlich, C., Eichinger-Hasenauer, S., Eisenberg, S. J., El Jabali, A., El Shahawy, M., Hernandes, M. E., Izal, A. E., Evonich, R., Evseeva, O., Ezhov, A., Fahmy, R., Fang, Q., Farsad, R., Fauchier, L., Favale, S., Fayard, M., Fedele, J. L., Fedele, F., Fedorishina, O., Fera, S. R., Gomes Ferreira, L. G., Ferreira, J., Ferri, C., Ferrier, A., Ferro, H., Finsen, A., First, B., Fischer, S., Fonseca, C., Almeida, L. F., Forman, S., Frandsen, B., French, W., Friedman, K., Friese, A., Fruntelata, A. G., Fujii, S., Fumagalli, S., Fundamenski, M., Furukawa, Y., Gabelmann, M., Gabra, N., Gadsboll, N., Galinier, M., Gammelgaard, A., Ganeshkumar, P., Gans, C., Quintana, A. G., Gartenlaub, O., Gaspardone, A., Genz, C., Georger, F., Georges, J. -L., Georgeson, S., Giedrimas, E., Gierba, M., Ortega, I. G., Gillespie, E., Giniger, A., Giudici, M. C., Gkotsis, A., Glotzer, T. V., Gmehling, J., Gniot, J., Goethals, P., Goldbarg, S., Goldberg, R., Goldmann, B., Golitsyn, S., Gomez, S., Mesa, J. G., Gonzalez, V. B., Gonzalez Hermosillo, J. A., Gonzalez Lopez, V. M., Gorka, H., Gornick, C., Gorog, D., Gottipaty, V., Goube, P., Goudevenos, I., Graham, B., Greer, G. S., Gremmler, U., Grena, P. G., Grond, M., Gronda, E., Gronefeld, G., Gu, X., Torres Torres, I. G., Guardigli, G., Guevara, C., Guignier, A., Gulizia, M., Gumbley, M., Gunther, A., Ha, A., Hahalis, G., Hakas, J., Hall, C., Han, B., Han, S., Hargrove, J., Hargroves, D., Harris, K. B., Haruna, T., Hayek, E., Healey, J., Hearne, S., Heffernan, M., Heggelund, G., Heijmeriks, J. A., Hemels, M., Hendriks, I., Henein, S., Her, S. -H., Hermany, P., Hernandez Del Rio, J. E., Higashino, Y., Hill, M., Hisadome, T., Hishida, E., Hoffer, E., Hoghton, M., Hong, K., Hong, S. K., Horbach, S., Horiuchi, M., Hou, Y., Hsing, J., Huang, C. -H., Huckins, D., Kathy, Hughe, Huizinga, A., Hulsman, E. L., Hung, K. -C., Hwang, G. -S., Ikpoh, M., Imberti, D., Ince, H., Indolfi, C., Inoue, S., Irles, D., Iseki, H., Israel, C. N., Iteld, B., Iyer, V., Jackson-Voyzey, E., Jaffrani, N., Jager, F., James, M., Jang, S. -W., Jaramillo, N., Jarmukli, N., Jeanfreau, R. J., Jenkins, R. D., Sanchez, C. J., Jimenez, J., Jobe, R., Joen-Jakobsen, T., Jones, N., Moura Jorge, J. C., Jouve, B., Jung, B. C., Jung, K. T., Jung, W., Kachkovskiy, M., Kafkala, K., Kalinina, L., Kallmunzer, B., Kamali, F., Kamo, T., Kampus, P., Kashou, H., Kastrup, A., Katsivas, A., Kaufman, E., Kawai, K., Kawajiri, K., Kazmierski, J. F., Keeling, P., Kerr Saraiva, J. F., Ketova, G., Khaira, A. S., Khripun, A., Kim, D. -I., Kim, Y. H., Kim, N. H., Kim, D. K., Kim, J. S., Kim, K. S., Kim, J. B., Kinova, E., Klein, A., Kmetzo, J. J., Kneller, G. L., Knezevic, A., Angela Koh, S. M., Koide, S., Kollias, A., Kooistra, J. A., Koons, J., Koschutnik, M., Kostis, W. J., Kovacic, D., Kowalczyk, J., Koziolova, N., Kraft, P., Kragten, J. A., Krantz, M., Krause, L., Krenning, B. J., Krikke, F., Kromhout, Z., Krysiak, W., Kumar, P., Kumler, T., Kuniss, M., Kuo, J. -Y., Kuppers, A., Kurrelmeyer, K., Kwak, C. H., Laboulle, B., Labovitz, A., Lai, W. T., Lam, A., Lam, Y. Y., Zanetti, F. L., Landau, C., Landini, G., Figueiredo, E. L., Larsen, T., Lavandier, K., Leblanc, J., Lee, M. H., Lee, C. -H., Lehman, J., Leitao, A., Lellouche, N., Lelonek, M., Lenarczyk, R., Lenderink, T., Gonzalez, S. L., Leong-Sit, P., Leschke, M., Ley, N., Li, Z., Li, X., Li, W., Lichy, C., Lieber, I., Limon Rodriguez, R. H., Lin, H., Liu, F., Liu, H., Esperon, G. L., Navarro, N. L., Lo, E., Lokshyn, S., Lopez, A., Lopez-Sendon, J. L., Lorga Filho, A. M., Lorraine, R. S., Luengas, C. A., Luke, R., Luo, M., Lupovitch, S., Lyrer, P., Ma, C., Ma, G., Madariaga, I., Maeno, K., Magnin, D., Maid, G., Mainigi, S. K., Makaritsis, K., Malhotra, R., Manning, R., Manolis, A., Manrique Hurtado, H. A., Mantas, I., Jattin, F. M., Maqueda, V., Marchionni, N., Ortuno, F. M., Santana, A. M., Martinez, J., Maskova, P., Hernandez, N. M., Matsuda, K., Maurer, T., Mauro, C., May, E., Mayer, N., Mcclure, J., Mccormack, T., Mcgarity, W., Mcintyre, H., Mclaurin, B., Medina Palomino, F. A., Melandri, F., Meno, H., Menzies, D., Mercader, M., Meyer, C., Meyer, B. J., Miarka, J., Mibach, F., Michalski, D., Michel, P., Chreih, R. M., Mikdadi, G., Mikus, M., Milicic, D., Militaru, C., Minaie, S., Minescu, B., Mintale, I., Mirault, T., Mirro, M. J., Mistry, D., Miu, N. V., Miyamoto, N., Moccetti, T., Mohammed, A., Nor, A. M., Mollerus, M., Molon, G., Mondillo, S., Moniz, P., Mont, L., Montagud, V., Montana, O., Monti, C., Moretti, L., Mori, K., Moriarty, A., Morka, J., Moschini, L., Moschos, N., Mugge, A., Mulhearn, T. J., Muresan, C., Muriago, M., Musial, W., Musser, C. W., Musumeci, F., Nageh, T., Nakagawa, H., Nakamura, Y., Nakayama, T., Nam, G. -B., Nanna, M., Natarajan, I., Nayak, H. M., Naydenov, S., Nazli, J., Nechita, A. C., Nechvatal, L., Negron, S. A., Neiman, J., Neuenschwander, F. C., Neves, D., Neykova, A., Miguel, R. N., Nijmeh, G., Nizov, A., Campos, R. N., Nossan, J., Novikova, T., Nowalany-Kozielska, E., Nsah, E., Nunez Fragoso, J. C., Nurgalieva, S., Nuyens, D., Nyvad, O., Odin de Los Rios Ibarra, M., O'Donnell, P., O'Donnell, M., Oh, S., Oh, Y. S., Oh, D., O'Hara, G., Oikonomou, K., Olivares, C., Oliver, R., Ruiz, R. O., Olympios, C., Anna, omaszuk-Kazberuk, Asensi, J. O., eena Padayattil, Jose, Padilla Padilla, F. G., Rios, V. P., Pajes, G., Pandey, A. S., Paparella, G., Paris, F., Park, H. W., Park, J. S., Parthenakis, F., Passamonti, E., Patel, R. J., Patel, J., Patel, M., Patrick, J., Jimenez, R. P., Paz, A., Pengo, V., Pentz, W., Perez, B., Perez Rios, A. M., Perez-Cabezas, A., Perlman, R., Persic, V., Perticone, F., Peters, T. K., Petkar, S., Pezo, L. F., Pflucke, C., Pham, D. N., Phillips, R. T., Phlaum, S., Pieters, D., Pineau, J., Pinter, A., Pinto, F., Pisters, R., Pivac, N., Pocanic, D., Podoleanu, C., Politano, A., Poljakovic, Z., Pollock, S., Garcea, J. P., Poppert, H., Porcu, M., Reino, A. P., Prasad, N., Precoma, D. B., Prelle, A., Prodafikas, J., Protasov, K., Pye, M., Qiu, Z., Quedillac, J. -M., Raev, D., Raffo Grado, C. A., Rahimi, S., Raisaro, A., Rama, B., Ramos, R., Ranieri, M., Raposo, N., Rashba, E., Rauch-Kroehnert, U., Reddy, R., Renda, G., Reza, S., Ria, L., Richter, D., Rickli, H., Rieker, W., Vera, T. R., Ritt, L. E., Roberts, D., Briones, I. R., Rodriguez Escudero, A. E., Pascual, C. 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S., Paparella, G., Paris, F., Park, H. W., Park, J. S., Parthenakis, F., Passamonti, E., Patel, R. J., Patel, J., Patel, M., Patrick, J., Jimenez, R. P., Paz, A., Pengo, V., Pentz, W., Perez, B., Perez Rios, A. M., Perez-Cabezas, A., Perlman, R., Persic, V., Perticone, F., Peters, T. K., Petkar, S., Pezo, L. F., Pflucke, C., Pham, D. N., Phillips, R. T., Phlaum, S., Pieters, D., Pineau, J., Pinter, A., Pinto, F., Pisters, R., Pivac, N., Pocanic, D., Podoleanu, C., Politano, A., Poljakovic, Z., Pollock, S., Garcea, J. P., Poppert, H., Porcu, M., Reino, A. P., Prasad, N., Precoma, D. B., Prelle, A., Prodafikas, J., Protasov, K., Pye, M., Qiu, Z., Quedillac, J. -M., Raev, D., Raffo Grado, C. A., Rahimi, S., Raisaro, A., Rama, B., Ramos, R., Ranieri, M., Raposo, N., Rashba, E., Rauch-Kroehnert, U., Reddy, R., Renda, G., Reza, S., Ria, L., Richter, D., Rickli, H., Rieker, W., Vera, T. R., Ritt, L. E., Roberts, D., Briones, I. R., Rodriguez Escudero, A. E., Pascual, C. 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V., Vora, K., Vranian, R. B., Wakefield, P., Wang, N., Wang, M., Wang, X., Wang, F., Wang, T., Warner, A. L., Watanabe, K., Wei, J., Weimar, C., Weiner, S., Weinrich, R., Wen, M. -S., Wiemer, M., Wiggers, P., Wilke, A., Williams, D., Williams, M. L., Witzenbichler, B., Wong, B., Lawrence Wong, K. S., Wozakowska-Kaplon, B., Wu, S., Wu, R. C., Wunderlich, S., Wyatt, N., Wylie, J. J., Xu, Y., Xu, X., Yamanoue, H., Yamashita, T., Bryan Yan, P. Y., Yang, T., Yao, J., Yeh, K. -H., Yin, W. H., Yotov, Y., Zahn, R., Zarich, S., Zenin, S., Zeuthen, E. L., Zhang, H., Zhang, D., Zhang, X., Zhang, P., Zhang, J., Zhao, S. P., Zhao, Y., Zhao, Z., Zheng, Y., Zhou, J., Zimmermann, S., Zini, A., Zizzo, S., Zong, W., Zukerman, L. S., and Crea F. (ORCID:0000-0001-9404-8846)

Abstract

Aim: The SAMe-TT2R2 score helps identify patients with atrial fibrillation (AF) likely to have poor anticoagulation control during anticoagulation with vitamin K antagonists (VKA) and those with scores >2 might be better managed with a target-specific oral anticoagulant (NOAC). We hypothesized that in clinical practice, VKAs may be prescribed less frequently to patients with AF and SAMe-TT2R2 scores >2 than to patients with lower scores. Methods and results: We analyzed the Phase III dataset of the Global Registry on Long-Term Oral Antithrombotic Treatment in Patients with Atrial Fibrillation (GLORIA-AF), a large, global, prospective global registry of patients with newly diagnosed AF and ≥1 stroke risk factor. We compared baseline clinical characteristics and antithrombotic prescriptions to determine the probability of the VKA prescription among anticoagulated patients with the baseline SAMe-TT2R2 score >2 and ≤ 2. Among 17,465 anticoagulated patients with AF, 4,828 (27.6%) patients were prescribed VKA and 12,637 (72.4%) patients an NOAC: 11,884 (68.0%) patients had SAMe-TT2R2 scores 0-2 and 5,581 (32.0%) patients had scores >2. The proportion of patients prescribed VKA was 28.0% among patients with SAMe-TT2R2 scores >2 and 27.5% in those with scores ≤2. Conclusions: The lack of a clear association between the SAMe-TT2R2 score and anticoagulant selection may be attributed to the relative efficacy and safety profiles between NOACs and VKAs as well as to the absence of trial evidence that an SAMe-TT2R2-guided strategy for the selection of the type of anticoagulation in NVAF patients has an impact on clinical outcomes of efficacy and safety. The latter hypothesis is currently being tested in a randomized controlled trial. Clinical trial registration: URL: https://www.clinicaltrials.gov//Unique identifier: NCT01937377, NCT01468701, and NCT01671007.

Published
2021

32. Evaluation of Short-Term Pacing Effect to Predict Long-Term Response to Cardiac Resynchronization Therapy: The TRAJECTORIES Study

Author

Santarelli G., Severi S., Tomasi C., Corsi C., Ciccotelli R., Molon G., Zanon F., Corzani A., Rossillo A., Biffi M., Zanotto G., Lanzoni L., Santarelli G., Severi S., Tomasi C., Corsi C., Ciccotelli R., Molon G., Zanon F., Corzani A., Rossillo A., Biffi M., Zanotto G., and Lanzoni L.

Subjects
Cardiac Resynchronization Therapy
Abstract

Cardiac resynchronization therapy (CRT) is an effective treatment for chronic symptomatic systolic heart failure with cardiac dyssynchrony, but about 1/3 of patients do not respond favorably to the therapy. We hypothesized that acute modifications of the coronary sinus (CS) pacing cathode movements induced by biventricular pacing may be related to resynchronization process and consequently may carry predictive power on CRT response. A method for the 3D reconstruction of CS lead's pacing cathode trajectory (3DTJ) throughout a cardiac cycle showed that trajectory's geometry suddenly changed in responders (R) upon starting of biventricular pacing, becoming less eccentric and more multi-directional. Our multicenter observational study aimed at evaluating the clinical value of 3DTJ. Out of 119 patients enrolled, 50 have ended follow-up and have been analyzed. Concordance between 3DTJ metrics and response was 82% overall (41/50), 91% in R (31/34), 62% in NR (10/16). The proposed 3DTJ metric showed high sensitivity (91%) with specificity=62%; PPV=84%, NPV=77%. From our data, 3DTJ seems a promising tool to acutely predict CS pacing site-specific response to CRT. Its investigational use as an intra-operatory, real-time guidance for selecting LV pacing sites may open new opportunities for CRT patients' selection and therapy delivery.

Published
2019

33. P544Evaluation of three-dimensional trajectory of pacing cathode pole in coronary sinus to predict long-term response to cardiac resynchronization therapy

Author

Tomasi, C, primary, Severi, S, additional, Zanon, F, additional, Molon, G, additional, Corzani, A, additional, Rossillo, A, additional, Biffi, M, additional, Marcantoni, L, additional, Costa, A, additional, Dal Monte, A, additional, Santarelli, G, additional, Lanzoni, L, additional, and Corsi, C, additional

Published
2020
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34. 48Remote monitoring of Heart Failure patients with a Multisensor ICD Algorithm: value of an alert-based follow-up strategy

Author

Pecora, D, primary, Tavoletta, V, additional, Dello Russo, A, additional, De Ruvo, E, additional, Ammirati, F, additional, La Greca, C, additional, Favale, S, additional, Petracci, B, additional, Molon, G, additional, Montella, G M, additional, Santini, L, additional, Nozza, C, additional, Valsecchi, S, additional, and Calo, L, additional

Published
2020
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35. Impact of COVID-19 pandemic on the clinical activities related to arrhythmias and electrophysiology in Italy: results of a survey promoted by AIAC (Italian Association of Arrhythmology and Cardiac Pacing)

Author

Boriani, G., Palmisano, P., Guerra, F., Bertini, M., Zanotto, G., Lavalle, C., Notarstefano, P., Accogli, M., Bisignani, G., Forleo, G. B., Landolina, M., D'Onofrio, A., Ricci, R., De Ponti, R., Luise, R., Grieco, P., Pangallo, A., Quirino, G., Talarico, A., De Bonis, S., Carbone, A., De Simone, A., Nappi, F., Rotondi, F., Stabile, G., Uran, C., Balla, C., Boggian, G., Carinci, V., Barbato, G., Corzani, A., Sabbatani, P., Erminio, M., Imberti, J. F., Malavasi, N., Pastori, P., Quartieri, F., Bottoni, N., Saporito, D., Virzi, S., Sassone, B., Zardini, M., Placci, A., Ziacchi, M., Massaro, G., Adamo, F., Scaccia, A., Spampinato, A., Biscione, F., Castro, A., Cauti, F., Rossi, P., Cinti, C., Gatto, M., Kol, A., Narducci, M. L., Pelargonio, G., Patruno, N., Pignalberi, C., Ricci, R. P., Ricciardi, D., Santini, L., Tancredi, M., Di Belardino, N., Pentimalli, F., Zoni-Berisso, M., Belotti, G., Chieffo, E., Cilloni, S., Doni, L. A., Gardini, A., Malaspina, D., Mazzone, P., Della Bella, P., Negro, R., Perego, G. B., Rordorf, R., Cipolletta, L., Russo, A. D., Luzi, M., Amellone, C., Ebrille, E., Favro, E., Lucciola, M. T., Devecchi, C., Rametta, F., Devecchi, F., Matta, M., Sant'Andrea, A. O., Santagostino, M., Dell'Era, G., Candida, T. R., Bonfantino, V. M., Gianfrancesco, D., Guido, A., Pellegrino, P. L., Pisano, E. C. L., Rillo, M., Palama, Z., Sai, R., Santobuono, V. E., Favale, S., Scicchitano, P., Nissardi, V., Campisi, G., Sgarito, G., Arena, G., Casorelli, E., Fumagalli, S., Giaccardi, M., Nesti, M., Padeletti, M., Rossi, A., Piacenti, M., Del Greco, M., Catanzariti, D., Manfrin, M., Werner, R., Marini, M., Andreoli, C., Fedeli, F., Mazza, A., Pagnotta, F., Ridarelli, M., Molon, G., and Rossillo, A.

Subjects
Male, Cardiac pacing, 030204 cardiovascular system & hematology, Ablation, Cardiac Resynchronization Therapy, 0302 clinical medicine, Surveys and Questionnaires, Health care, Pandemic, Registries, 030212 general & internal medicine, Acute management, Secondary prevention, Atrial fibrillation, Arrhythmia, COVID-19, Emergency, Implantable cardioverter defibrillators, Pacemakers, Remote monitoring, Middle Aged, Electrophysiology, Italy, Emergency Medicine, Female, Coronavirus Infections, Adult, medicine.medical_specialty, Atrial fbrillation, Coronavirus disease 2019 (COVID-19), Pneumonia, Viral, Implantable cardioverter defbrillators, NO, 03 medical and health sciences, Physicians, medicine, Internal Medicine, Humans, Pandemics, Ablation, Arrhythmia, Atrial fbrillation, Emergency, Implantable cardioverter defbrillators, Pacemakers, Remote monitoring, COVID-19, Aged, business.industry, Outbreak, Arrhythmias, Cardiac, medicine.disease, Im - Original, Emergency medicine, business
Abstract

COVID-19 outbreak had a major impact on the organization of care in Italy, and a survey to evaluate provision of for arrhythmia during COVID-19 outbreak (March–April 2020) was launched. A total of 104 physicians from 84 Italian arrhythmia centres took part in the survey. The vast majority of participating centres (95.2%) reported a significant reduction in the number of elective pacemaker implantations during the outbreak period compared to the corresponding two months of year 2019 (50.0% of centres reported a reduction of > 50%). Similarly, 92.9% of participating centres reported a significant reduction in the number of implantable cardioverter-defibrillator (ICD) implantations for primary prevention, and 72.6% a significant reduction of ICD implantations for secondary prevention (> 50% in 65.5 and 44.0% of the centres, respectively). The majority of participating centres (77.4%) reported a significant reduction in the number of elective ablations (> 50% in 65.5% of the centres). Also the interventional procedures performed in an emergency setting, as well as acute management of atrial fibrillation had a marked reduction, thus leading to the conclusion that the impact of COVID-19 was disrupting the entire organization of health care, with a massive impact on the activities and procedures related to arrhythmia management in Italy. Electronic supplementary material The online version of this article (10.1007/s11739-020-02487-w) contains supplementary material, which is available to authorized users.

Published
2020

38. P577Early experience with the first pacemakers to directly connect with smart devices for remote monitoring

Author

Tarakji, K, primary, Zweibel, S, additional, Seiler, A, additional, Roberts, P, additional, Shaik, N, additional, Silverstein, J, additional, Patwala, A, additional, Mittal, S, additional, Molon, G, additional, Augello, G, additional, Porfilio, A, additional, Holloman, K, additional, Varma, N, additional, Sears, S, additional, and Turakhia, M, additional

Published
2019
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39. P2872Remote management of heart failure patients with the multisensor ICD alert: preliminary results from the Italian pilot experience

Author

De Ruvo, E, primary, Capucci, A, additional, Santini, L, additional, Pecora, D, additional, Favale, S, additional, Molon, G, additional, Petracci, B, additional, Bianchi, V, additional, Cipolletta, L, additional, Calo', L, additional, Ammirati, F, additional, La Greca, C, additional, Santobuono, V E, additional, Campari, M, additional, and D'Onofrio, A, additional

Published
2019
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40. The Changing Landscape for Stroke Prevention in AF: Findings From the GLORIA-AF Registry Phase 2

Author

Huisman, M. V., Rothman, K. J., Paquette, M., Teutsch, C., Diener, H. -C., Dubner, S. J., Halperin, J. L., C. S., Ma, Zint, K., Elsaesser, A., Bartels, D. B., Lip, G. Y. H., Abban, D., Abdul, N., Abelson, M., Ackermann, A., Adams, F., Adams, L., Adragao, P., Ageno, W., Aggarwal, R., Agosti, S., Marin, J. A., Aguilar, F., Aguilar Linares, J. A., Aguinaga, L., Ahmad, Z., Ainsworth, P., Al Ghalayini, K., Al Ismail, S., Alasfar, A., Alawwa, A., Al-Dallow, R., Alderson, L., Alexopoulos, D., Ali, A., Ali, M., Aliyar, P., Al-Joundi, T., Al Mahameed, S., Almassi, H., Almuti, K., Al-Obaidi, M., Alshehri, M., Altmann, U., Alves, A. R., Al-Zoebi, A., Amara, W., Amelot, M., Amjadi, N., Ammirati, F., Andrawis, N., Angoulvant, D., Annoni, G., Ansalone, G., Antonescu, S. A., Ariani, M., Arias, J. C., Armero, S., Arora, R., Arora, C., Ashcraft, W., Aslam, M. S., Astesiano, A., Audouin, P., Augenbraun, C., Aydin, S., Azar, R., Azim, A., Aziz, S., Backes, L. M., Baig, M., Bains, S., Bakbak, A., Baker, S., Bakhtiar, K., Bala, R., Banayan, J., Bandh, S., Bando, S., Banerjee, S., Bank, A., Barbarash, O., Baron, G., Barr, C., Barrera, C., Barton, J., Kes, V. B., Baula, G., Bayeh, H., Bazargani, N., Behrens, S., Bell, A., Benezet-Mazuecos, J., Benhalima, B., Berdague, P., Berg van den, B. J., Bergen van, P. F. M. M., Berngard, E., Bernstein, R., Berrospi, P., Berti, S., Bertomeu, V., Berz, A., Bettencourt, P., Betzu, R., Beyer-Westendorf, J., Bhagwat, R., Black, T., Blanco Ibaceta, J. H., Bloom, S., Blumberg, E., Bo, M., Bockisch, V., Bohmer, E., Bongiorni, M. G., Boriani, G., Bosch, R., Boswijk, D. J., Bott, J., Bottacchi, E., Kalan, M. B., Brandes, A., Bratland, B., Brautigam, D., Breton, N., Brouwers, P. J. A. M., Browne, K., Bruguera, J., Brunehaut, M., Brunschwig, C., Buathier, H., Buhl, A., Bullinga, J., Butcher, K., Cabrera Honorio, J. W., Caccavo, A., Cadinot, D., Cai, S., Calvi, V., Camm, J., Candeias, R., Capo, J., Capucci, A., Cardoso, J. N., Duarte Vera, Y. C., Carlson, B., Carvalho, P., Cary, S., Casanova, R., Casu, G., Cattan, S., Cavallini, C., Cayla, G., Cha, T. J., Cha, K. S., Chaaban, S., Chae, J. K., Challappa, K., Chand, S., Chandrashekar, H., Chang, M., Charbel, P., Chartier, L., Chatterjee, K., Cheema, A., Chen, S. -A., Chevallereau, P., Chiang, F. -T., Chiarella, F., Chih-Chan, L., Cho, Y. K., Choi, D. J., Chouinard, G., Danny, Chow, H. F., Chrysos, D., Chumakova, G., Jose Roberto Chuquiure Valenzuela, E. J., Cieza-Lara, T., Nica, V. C., Ciobotaru, V., Cislowski, D., Citerne, O., Claus, M., Clay, A., Clifford, P., Cohen, S., Cohen, A., Colivicchi, F., Collins, R., Compton, S., Connors, S., Conti, A., Buenostro, G. C., Coodley, G., Cooper, M., Corbett, L., Corey, O., Coronel, J., Corrigan, J., Cotrina Pereyra, R. Y., Cottin, Y., Coutu, B., Cracan, A., Crean, P., Crenshaw, J., Crijns, H. J. G. M., Crump, C., Cucher, F., Cudmore, D., Cui, L., Culp, J., Darius, H., Dary, P., Dascotte, O., Dauber, I., Davee, T., Davies, R., Davis, G., Davy, J. -M., Dayer, M., De La Briolle, A., de Mora, M., De Teresa, E., De Wolf, L., Decoulx, E., Deepak, S., Defaye, P., Del-Carpio Munoz, F., Brkljacic, D. D., Deluche, L., Destrac, S., Deumite, N. J., Di Legge, S., Dibon, O., Diemberger, I., Dillinger, J., Dionisio, P., Naydenov, S., Dotani, I., Dotcheva, E., D'Souza, A., Dubrey, S., Ducrocq, X., Dupljakov, D., Duthinh, V., Dutra, O. P., Dutta, D., Duvilla, N., Dy, J., Dziewas, R., Eaton, C., Eaves, W., Ebinger, M., Eck van, J. W. M., Edwards, T., Egocheaga, I., Ehrlich, C., Eisenberg, S., El Hallak, A., El Jabali, A., El Mahmoud, R., El Shahawy, M., Eldadah, Z., Elghelbazouri, F., Elhag, O., El-Hamdani, M., Elias, D., Ellery, A., El-Sayed, H., Elvan, A., Erickson, B., Espaliat, E., Essandoh, L., Everington, T., Evonich, R., Ezhov, A., Facila, L., Farsad, R., Fayard, M., Fedele, F., Gomes Ferreira, L. G., Ferreira, D., Santos, J. F., Ferrier, A., Finsen, A., First, B., Fisher, R., Floyd, J., Folk, T., Fonseca, C., Fonseca, L., Forman, S., Forsgren, M., Foster, M., Foster, N., Frais, M., Frandsen, B., Frappe, T., Freixa, R., French, W., Freydlin, M., Frickel, S., Fruntelata, A. G., Fujii, S., Fujino, Y., Fukunaga, H., Furukawa, Y., Gabelmann, M., Gabris, M., Gadsboll, N., Galin, P., Galinier, M., Ganim, R., Garcia, R., Quintana, A. G., Gartenlaub, O., Genz, C., Georger, F., Georges, J. -L., Georgeson, S., Ghanbasha, A., Giedrimas, E., Gierba, M., Gillespie, E., Giniger, A., Gkotsis, A., Gmehling, J., Gniot, J., Goethals, P., Goldberg, R., Goldmann, B., Goldscher, D., Golitsyn, S., Gomez Lopez, E. A., Gomez Mesa, J. E., Gonzalez, E., Cocina, E. G., Juanatey, C. G., Gorbunov, V., Gordon, B., Gorka, H., Gornick, C., Gorog, D., Goss, F., Gotte, A., Goube, P., Goudevenos, I., Goulden, D., Graham, B., Grande, A., Greco, C., Green, M., Greer, G., Gremmler, U., Grena, P., Grinshstein, Y., Grond, M., Gronda, E., Grondin, F., Gronefeld, G., Groot de, J. R., Guardigli, G., Guarnieri, T., Caiedo, C. G., Guignier, A., Gulizia, M., Gumbley, M., Gupta, D., Hack, T., Haerer, W., Hakas, J., Hall, C., Hampsey, J., Hananis, G., Hanbali, B., Handel, F., Hargrove, J., Hargroves, D., Harris, K., Hartley, D., Haruna, T., Hata, Y., Hayek, E., Healey, J., Hearne, S., Heggelund, G., Hemels, M. E. W., Hemery, Y., Henein, S., Henz, B., Her, S. -H., Hermany, P., Hernandes, M. E., Higashino, Y., Hill, M., Hisadome, T., Hishida, E., Hitchcock, J., Hoffer, E., Hoghton, M., Holmes, C., Hong, S. K., Houppe Nousse, M. -P., Howard, V., Hsu, L. F., Huang, C. -H., Huckins, D., Huehnergarth, K., Huizenga, A., Huntley, R., Hussein, G., Hwang, G. -S., Igbokidi, O., Iglesias, I., Ikpoh, M., Imberti, D., Ince, H., Indolfi, C., Ionova, T., Ip, J., Irles, D., Iseki, H., Ismail, Y., Israel, N., Isserman, S., Iteld, B., Ivanchura, G., Iyer, R., Iyer, V., Iza Villanueva, R. O., Jackson-Voyzey, E., Jaffrani, N., Jager, F., Jain, M., James, M., Jamon, Y., Jang, S. W., Pereira Jardim, C. A., Jarmukli, N., Jeanfreau, R., Jenkins, R., Jiang, X., Jiang, H., Jiang, T., Jiang, N., Jimenez, J., Jobe, R., Joffe, I., Johansson, B., Jones, N., Moura Jorge, J. C., Jouve, B., Jundi, M., Jung, W., Jung, B. C., Jung, K. T., Kabbani, S., Kabour, A., Kafkala, C., Kajiwara, K., Kalinina, L., Kampus, P., Kanda, J., Kapadia, S., Karim, A., Karolyi, L., Kashou, H., Kastrup, A., Katsivas, A., Kaufman, E., Kawai, K., Kawajiri, K., Kazmierski, J., Keeling, P., Kerfes, G. A., Kerr Saraiva, J. F., Ketova, G., Khaira, A., Khalid, M., Khludeeva, E., Khripun, A., Kim, D. I., Kim, D. K., Kim, N. H., Kim, K. S., Kim, Y. -H., Kim, J. B., Kim, J. S., Kinova, E., Klein, A., Kleinschnitz, C., Kmetzo, J., Kneller, G. L., Knezevic, A., Koch, S., Koenig, K., Angela Koh, S. M., Kohrmann, M., Koons, J., Korabathina, R., Korennova, O., Koschutnik, M., Kosinski, E., Kovacic, D., Kowalczyk, J., Koziolova, N., Kragten, J. A., Krause, L. U., Kreidieh, I., Krenning, B. J., Krishnaswamy, K., Krysiak, W., Kuck, K. -H., Kumar, S., Kumler, T., Kuniss, M., Kuo, J. -Y., Kuppers, A., Kurrelmeyer, K., Kwan, T., Kyo, E., Labovitz, A., Lacroix, A., Lam, A., Lanas Zanetti, F. T., Landau, C., Landini, G., Lang, W., Larsen, T. B., Laske, V., Lavandier, K., Law, N., Lee, M. H., Lee, D., Leitao, A., Lejay, D., Lelonek, M., Lenarczyk, R., Leprince, P., Lequeux, B., Leschke, M., Ley, N., Li, Z., Li, Y., Li, X., Li, W., Liang, J., Lieber, I., Lillestol, M., Limon Rodriguez, R. H., Lin, H., Lip, G., Litchfield, J., Liu, Z., Liu, X., Liu, Y., Liu, F., Liu, W., Llamas Esperon, G. A., Llisterri, J. L., Lo, T., Lo, E., Lobos, J. M., Lodde, B. -P., Loiselet, P., Lopez-Sendon, J., Lorga Filho, A. M., Lori, I., Luo, M., Lupovitch, S., Lyrer, P., Zuhairy, H. M., Ma, C., Ma, G., Ma, H., Madariaga, I., Maeno, K., Magnin, D., Mahmood, S., Mahood, K., Maid, G., Mainigi, S., Makaritsis, K., Maldonado Villalon, J. A., Malhotra, R., Malik, A., Mallecourt, C., Mallik, R., Manning, R., Manolis, A., Mantas, I., Manzur Jattin, F. G., Marcionni, N., Marin, F., Santana, A. M., Martinez, J., Martinez, L., Maskova, P., Hernandez, N. M., Matskeplishvili, S., Matsuda, K., Mavri, A., May, E., Mayer, N., Mazon, P., Mcclure, J., Mccormack, T., Mcgarity, W., Mcguire, M., Mcintyre, H., Mclaughlin, P., Mclaurin, B., Medina Palomino, F. A., Mehta, P., Mehzad, R., Meinel, A., Melandri, F., Mena, A., Meno, H., Menzies, D., Metcalf, K., Meyer, B., Miarka, J., Mibach, F., Michalski, D., Michel, P., Chreih, R. M., Mikdadi, G., Mikhail, M., Mikus, M., Milicic, D., Militaru, C., Miller, G., Milonas, C., Minescu, B., Mintale, I., Miralles, A., Mirault, T., Mistry, D., Mitchell, G., Miu, N. V., Miyamoto, N., Moccetti, T., Mohammed, A., Nor, A. M., Molina de Salazar, D. I., Molon, G., Molony, D., Mondillo, S., Mont, L., Moodley, R., Moore, R., Ribeiro Moreira, D. A., Mori, K., Moriarty, A., Morka, J., Moschos, N., Mota Gomes, M. A., Mousallem, N., Moya, A., Mugge, A., Mulhearn, T., Muller, J. -J., Muresan, C. M., Muse, D., Musial, W., Musumeci, F., Nadar, V., Nageh, T., Nair, P., Nakagawa, H., Nakamura, Y., Nakayama, T., Nam, K. -B., Napalkov, D., Natarajan, I., Nayak, H., Nechvatal, L., Neiman, J., Nerheim, P., Neuenschwander, F. C., Nishida, K., Nizov, A., Novikova, T., Novo, S., Nowalany-Kozielska, E., Nsah, E., Nunez Fragoso, J. C., Nyvad, O., de Los Rios Ibarra, M. O., O'Donnell, M., O'Donnell, P., D. J., Oh, Y. S., Oh, Daniel Oh, C. T., O'Hara, G., Oikonomou, K., Olalla, J. J., Olivari, Z., Oliver, R., Olympios, C., Osborne, J., Osca, J., Osman, R., Osunkoya, A., Padanilam, B., Panchenko, E., Pandey, A. S., Vicenzo de Paola, A. A., Paraschos, A., Pardell, H., Park, H. W., Park, J. S., Parkash, R., Parker, I., Parrens, E., Parris, R., Passamonti, E., Patel, J., Patel, R., Pentz, W. H., Persic, V., Perticone, F., Peters, P., Petkar, S., Pezo, L. F., Pham, D., Cao Phai, G. P., Phlaum, S., Pineau, J., Pineda-Velez, A., Pini, R., Pinter, A., Pinto, F., Pirelli, S., Pivac, N., Pizzini, A. 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A., Spinar, J., Sprigings, D., Spyropoulos, A., Stakos, D., Steinberg, A., Steinwender, C., Stergiou, G., Stites, H. W., Stoikov, A., Strasser, R., Streb, W., Styliadis, I., Su, G., Su, X., Suarez, R. M., Sudnik, W., Sueyoshi, A., Sukles, K., Sun, L., Suneja, R., Svensson, P., Ziekenhuis, A., Szavits-Nossan, J., Taggeselle, J., Takagi, Y., Takhar, A., Tallet, J., Tamm, A., Tanaka, S., Tanaka, K., Tang, A., Tang, S., Tassinari, T., Tayama, S., Tayebjee, M., Tebbe, U., Teixeira, J., Tesloianu, D. N., Tessier, P., The, S. H. K., Thevenin, J., Thomas, H., Timsit, S., Topkis, R., Torosoff, M., Touze, E., Traissac, T., Trendafilova, E., Troyan, B., Tsai, W. K., Tse, H. F., Tsutsui, H., Tsutsui, T., Tuininga, Y. S., Turakhia, M., Turk, S., Turner, W., Tveit, A., Twiddy, S., Tytus, R., Ukrainski, G., Valdovinos Chavez, S. B., Van De Graaff, E., Vanacker, P., Vardas, P., Vargas, M., Vassilikos, V., Vazquez, J., Venkataraman, A., Verdecchia, P., Vester, E. 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J, Zimmermann, S, Zimmermann, R, Zukerman, L, and Zwaan van der, C

Subjects
Male, oral anticoagulation, Internationality, Middle Aged, registry, Antithrombins, Dabigatran, Stroke, Cross-Sectional Studies, Fibrinolytic Agents, Humans, Female, atrial fibrillation, Prospective Studies, Registries, Cardiology and Cardiovascular Medicine, Aged, Atrial Fibrillation
Abstract

Background GLORIA-AF (Global Registry on Long-Term Oral Antithrombotic Treatment in Patients with Atrial Fibrillation) is a prospective, global registry program describing antithrombotic treatment patterns in patients with newly diagnosed nonvalvular atrial fibrillation at risk of stroke. Phase 2 began when dabigatran, the first non–vitamin K antagonist oral anticoagulant (NOAC), became available. Objectives This study sought to describe phase 2 baseline data and compare these with the pre-NOAC era collected during phase 1. Methods During phase 2, 15,641 consenting patients were enrolled (November 2011 to December 2014); 15,092 were eligible. This pre-specified cross-sectional analysis describes eligible patients’ baseline characteristics. Atrial fibrillation disease characteristics, medical outcomes, and concomitant diseases and medications were collected. Data were analyzed using descriptive statistics. Results Of the total patients, 45.5% were female; median age was 71 (interquartile range: 64, 78) years. Patients were from Europe (47.1%), North America (22.5%), Asia (20.3%), Latin America (6.0%), and the Middle East/Africa (4.0%). Most had high stroke risk (CHA2DS2-VASc [Congestive heart failure, Hypertension, Age ≥75 years, Diabetes mellitus, previous Stroke, Vascular disease, Age 65 to 74 years, Sex category] score ≥2; 86.1%); 13.9% had moderate risk (CHA2DS2-VASc = 1). Overall, 79.9% received oral anticoagulants, of whom 47.6% received NOAC and 32.3% vitamin K antagonists (VKA); 12.1% received antiplatelet agents; 7.8% received no antithrombotic treatment. For comparison, the proportion of phase 1 patients (of N = 1,063 all eligible) prescribed VKA was 32.8%, acetylsalicylic acid 41.7%, and no therapy 20.2%. In Europe in phase 2, treatment with NOAC was more common than VKA (52.3% and 37.8%, respectively); 6.0% of patients received antiplatelet treatment; and 3.8% received no antithrombotic treatment. In North America, 52.1%, 26.2%, and 14.0% of patients received NOAC, VKA, and antiplatelet drugs, respectively; 7.5% received no antithrombotic treatment. NOAC use was less common in Asia (27.7%), where 27.5% of patients received VKA, 25.0% antiplatelet drugs, and 19.8% no antithrombotic treatment. Conclusions The baseline data from GLORIA-AF phase 2 demonstrate that in newly diagnosed nonvalvular atrial fibrillation patients, NOAC have been highly adopted into practice, becoming more frequently prescribed than VKA in Europe and North America. Worldwide, however, a large proportion of patients remain undertreated, particularly in Asia and North America. (Global Registry on Long-Term Oral Antithrombotic Treatment in Patients With Atrial Fibrillation [GLORIA-AF]; NCT01468701)

Published
2017

41. Electrocardiographic RR Interval Dynamic Analysis to Identify Acute Stroke Patients at High Risk for Atrial Fibrillation Episodes During Stroke Unit Admission

Author

Adami, A, Gentile, C, Hepp, T, Molon, G, Gigli, GL, Valente, M, Thijs, V, Adami, A, Gentile, C, Hepp, T, Molon, G, Gigli, GL, Valente, M, and Thijs, V

Abstract

Patients at short-term risk of paroxysmal atrial fibrillation (PAF) often exhibit increased RR interval variability during sinus rhythm. We studied if RR dynamic analysis, applied in the first hours after stroke unit (SU) admission, identified acute ischemic stroke patients at higher risk for subsequent PAF episodes detected within the SU hospitalization. Acute ischemic stroke patients underwent continuous cardiac monitoring (CCM) using standard bedside monitors immediately after SU admission. The CCM tracks from the first 48 h were analyzed using a telemedicine service (SRA clinic, Apoplex Medical, Germany). Based on the RR dynamics, the stroke risk analysis (SRA) algorithm stratified the risk for PAF as follows: low risk for PAF, high risk for PAF, presence of manifest AF. The subsequent presence/absence of PAF during the whole SU hospitalization was ruled out using all available CCMs, standard ECGs, or 24-h Holter ECGs. Two hundred patients (40% females, mean age 71 ± 16 years) were included. According to the initial SRA analysis, 111 patients (56%) were considered as low risk for PAF, 52 (26%) as high risk while 37 patients (18%) had manifest AF. A low-risk level SRA was associated with a reduced probability for subsequent PAF detection (1/111, 0.9%, 95% CI 0-4.3%) while a high-risk level SRA predicted an increased probability (20/52, 38.5% (95% CI 25-52%). RR dynamic analysis performed in the first hours after ischemic stroke may stratify patients into categories at low or high risk for forthcoming paroxysmal AF episodes detected within the SU hospitalization.

Published
2019

47. P5744Long-term response prediction to cardiac resynchronization therapy by acute pacing-induced changes in 3D trajectory of pacing cathode pole in coronary sinus: preliminary results of TRAJECTORIES study

Author

Tomasi, C, primary, Molon, G, additional, Marcantoni, L, additional, Zanon, F, additional, Corzani, A, additional, Rossillo, A, additional, Biffi, M, additional, Zanotto, G, additional, Severi, S, additional, Lanzoni, L, additional, and Corsi, C, additional

Published
2018
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48. P5762Are the repeat cryoablations after index RF ablation safe and effective? Insight from a multicentric observational data collection

Author

Arena, G, primary, Iacopino, S, additional, Pieragnoli, P, additional, Curnis, A, additional, Manfrin, M, additional, Tondo, C, additional, Catanzariti, D, additional, Allocca, G, additional, Senatore, G, additional, Molon, G, additional, Sciarra, L, additional, Bertaglia, M, additional, and Verlato, R, additional

Published
2018
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50. P1103Safety and efficacy of repeat cryoablation after index RF ablation: insight from a multicentric observational data collection

Author

Verlato, R, primary, Pieragnoli, P, additional, Curnis, A, additional, Manfrin, M, additional, Tondo, C, additional, Catanzariti, D, additional, Allocca, G, additional, Senatore, G, additional, Molon, G, additional, Sciarra, L, additional, Arena, G, additional, Bertaglia, M, additional, and Iacopino, S, additional

Published
2018
Full Text
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