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33 results on '"Moloney, Cara"'

5. Enabling high-fidelity personalised pharmaceutical tablets through multimaterial inkjet 3D printing with a water-soluble excipient

Author

Rivers, Geoffrey, Lion, Anna, Putri, Nur Rofiqoh Eviana, Rance, Graham A., Moloney, Cara, Taresco, Vincenzo, Crucitti, Valentina Cuzzucoli, Constantin, Hannah, Evangelista Barreiros, Maria Inês, Cantu, Laura Ruiz, Tuck, Christopher J., Rose, Felicity R.A.J., Hague, Richard J.M., Roberts, Clive J., Turyanska, Lyudmila, Wildman, Ricky D., and He, Yinfeng

Published
2024
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7. Poly (diglycerol adipate) variants as enhanced nanocarrier replacements in drug delivery applications

Author

Jacob, Philippa L., Brugnoli, Benedetta, Del Giudice, Alessandra, Phan, Hien, Chauhan, Veeren M., Beckett, Laura, Gillis, Richard B., Moloney, Cara, Cavanagh, Robert J., Krumins, Eduards, Reynolds-Green, Morgan, Lentz, Joachim C., Conte, Claudia, Cuzzucoli Crucitti, Valentina, Couturaud, Benoit, Galantini, Luciano, Francolini, Iolanda, Howdle, Steven M., and Taresco, Vincenzo

Published
2023
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11. Enabling High-Fidelity Personalized Pharmaceutical Tablets Through Multimaterial Inkjet 3D Printing with a Water-Soluble Excipient

Author

Rivers, Geoffrey, primary, Lion, Anna, additional, Putri, Nur Rofiqoh Eviana, additional, Rance, Graham A., additional, Moloney, Cara, additional, Taresco, Vincenzo, additional, Crucitti, Valentina Cuzzucoli, additional, Constantin, Hanna, additional, Evangelista Barreiros, Maria Ines, additional, Cantu, Laura Ruiz, additional, Tuck, Christopher J., additional, Rose, Felicity RAJ, additional, Hague, Richard J.M., additional, Robert, Clive, additional, Turyanska, Lyudmila, additional, Wildman, Ricky D., additional, and He, Yinfeng, additional

Published
2024
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12. Glycerol-based sustainably sourced resin for volumetric printing

Author

Krumins, Eduards, primary, Lentz, Joachim C., additional, Sutcliffe, Ben, additional, Sohaib, Ali, additional, Jacob, Philippa L., additional, Brugnoli, Benedetta, additional, Cuzzucoli Crucitti, Valentina, additional, Cavanagh, Robert, additional, Owen, Robert, additional, Moloney, Cara, additional, Ruiz-Cantu, Laura, additional, Francolini, Iolanda, additional, Howdle, Steven M., additional, Shusteff, Maxim, additional, Rose, Felicity R. A. J., additional, Wildman, Ricky D., additional, He, Yinfeng, additional, and Taresco, Vincenzo, additional

Published
2024
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17. A holistic NMR framework to understand environmental impact: Examining the impacts of superparamagnetic iron oxide nanoparticles (SPIONs) in Daphnia magna via imaging, spectroscopy, and metabolomics

Author

Jenne, Amy, Soong, Ronald, Gruschke, Oliver, Bastawrous, Monica, Monks, Patricia, Moloney, Cara, Wu, Bing, Simpson, Andre, Jenne, Amy, Soong, Ronald, Gruschke, Oliver, Bastawrous, Monica, Monks, Patricia, Moloney, Cara, Wu, Bing, and Simpson, Andre

Abstract

Contains fulltext : 298319.pdf (Publisher’s version ) (Closed access), 31 oktober 2022

Published
2023

19. Chain-extension in hyperbranched polymers alters tissue distribution and cytotoxicity profiles in orthotopic models of triple negative breast cancers

Author

Moloney, Cara, primary, Mehradnia, Fatemeh, additional, Cavanagh, Robert J., additional, Ibrahim, Asmaa, additional, Pearce, Amanda K., additional, Ritchie, Alison A., additional, Clarke, Philip, additional, Rahman, Ruman, additional, Grabowska, Anna M., additional, and Alexander, Cameron, additional

Published
2023
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21. A holistic NMR framework to understand environmental impact: Examining the impacts of superparamagnetic iron oxide nanoparticles (SPIONs) inDaphnia magnavia imaging, spectroscopy, and metabolomics

Author

Jenne, Amy, primary, Soong, Ronald, additional, Gruschke, Oliver, additional, Bastawrous, Monica, additional, Monks, Patricia, additional, Moloney, Cara, additional, Brougham, Dermot F., additional, Busse, Falko, additional, Bermel, Wolfgang, additional, Courtier‐Murias, Denis, additional, Wu, Bing, additional, and Simpson, Andre, additional

Published
2022
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23. Oxygen-Tolerant RAFT Polymerization Initiated by Living Bacteria

Author

Bennett, Mechelle R., primary, Moloney, Cara, additional, Catrambone, Francesco, additional, Turco, Federico, additional, Myers, Benjamin, additional, Kovacs, Katalin, additional, Hill, Philip J., additional, Alexander, Cameron, additional, Rawson, Frankie J., additional, and Gurnani, Pratik, additional

Published
2022
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25. N-Hydroxyethyl acrylamide as a functional eROP initiator for the preparation of nanoparticles under “greener” reaction conditions

Author

Lentz, Joachim C., primary, Cavanagh, Robert, additional, Moloney, Cara, additional, Falcone Pin, Bruno, additional, Kortsen, Kristoffer, additional, Fowler, Harriet R., additional, Jacob, Philippa L., additional, Krumins, Eduards, additional, Clark, Charlotte, additional, Machado, Fabricio, additional, Breitkreuz, Nicholas, additional, Cale, Ben, additional, Goddard, Amy R., additional, Hirst, Jonathan D., additional, Taresco, Vincenzo, additional, and Howdle, Steven M., additional

Published
2022
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28. Enhanced Stability and Emission Properties of Perylene Dyes by Surface Tethering: Preparation of Fluorescent Ru Nanoparticle Suspensions by Alkyne Linker Chemistry.

Author

Morais, Eduardo, Moloney, Cara, O'Modhrain, Colin, McKiernan, Eoin, Brougham, Dermot F., and Sullivan, James A.

Subjects
*SURFACE preparation, *PERYLENE, *SURFACE passivation, *BOUND states, *DYES & dyeing, *FLUORESCENT dyes
Abstract

Spherical ruthenium nanoparticles (NPs) with a narrow size distribution were synthesised in ethanol by a facile low‐temperature solvothermal process without the assistance of templates, structure‐directing agents or post annealing/reduction treatments. Surface passivation with a fluorescent perylene dye (EP), and with silane ligands (ETMS), both initially bearing alkyne groups and subsequently forming vinylidene linkages, provided stable suspensions of the marginally soluble free EP. Quantitative analysis of the suspension gave an estimated EP surface coverage of 15 %, corresponding to an EP/ETMS mole ratio of ≈1:6. Photophysical evaluation of the bound and free dye revealed similar absorption bands and extinction coefficients and improved properties for the bound state, including enhanced fluorescence in the visible range for the bound dye, an extended absorption range into the near‐UV providing strong emission in the visible, and significantly improved photostability. The physical basis of the enhanced photophysical properties, potential routes to further improvements and the implications for applications are discussed. [ABSTRACT FROM AUTHOR]

Published
2021
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30. Photoswitchable Layer-by-layer Coatings Based on Photochromic Polynorbornenes Bearing Spiropyran Side Groups

Author

Química analítica, Kimika analitikoa, Campos, Paula P., Dunne, Aishling, Delaney, Colm, Moloney, Cara, Moulton, Simon E., Benito López, Fernando, Ferreira, Marystela, Diamond, Dermot, Florea, Larisa, Química analítica, Kimika analitikoa, Campos, Paula P., Dunne, Aishling, Delaney, Colm, Moloney, Cara, Moulton, Simon E., Benito López, Fernando, Ferreira, Marystela, Diamond, Dermot, and Florea, Larisa

Abstract

Micro-capillaries, capable of light-regulated binding and qualitative detection of divalent metal ions in continuous flow, have been realised through functionalisation with spiropyran photochromic brush-type coatings. Upon irradiation with UV light, the coating switches from the passive non-binding spiropyran form to the active merocyanine form, which binds different divalent metal ions (Zn2+, Co2+, Cu2+, Ni2+, Cd2+), as they pass through the micro-capillary. Furthermore, the merocyanine visible absorbance spectrum changes upon metal ion binding, enabling the ion uptake to be detected optically. Irradiation with white light causes reversion of the merocyanine to the passive spiropyran form, with simultaneous release of the bound metal ion from the micro-capillary coating.

Published
2018

31. Photoswitchable layer-by-layer coatings based on photochromic polynorbornenes bearing spiropyran side groups

Author

Campos, Paula, Dunne, Aishling, Delaney, Colm, Moloney, Cara, Moulton, Simon E., Benito-Lopez, Fernando, Ferreira, Marystela, Diamond, Dermot, Florea, Larisa, Campos, Paula, Dunne, Aishling, Delaney, Colm, Moloney, Cara, Moulton, Simon E., Benito-Lopez, Fernando, Ferreira, Marystela, Diamond, Dermot, and Florea, Larisa

Abstract

Herein, we present the synthesis of linear photochromic norbornene polymers bearing spiropyran side groups (poly(SP-R)), and their assembly into LbL films on glass substrates when converted to the poly(MC-R) under UV irradiation. The LbL films were composed of bilayers of poly(allylamine hydrochloride) (PAH) and poly(MC-R), forming (PAH/poly(MC-R))n coatings. The MC form presents a significant absorption band in the visible spectral region which allowed the LbL deposition process to be tracked by UV-Vis spectroscopy, showing a linear increase of the characteristic MC absorbance band with increased number of bilayers. The thickness and morphology of the (PAH/poly(MC-R))n films were characterised by ellipsometry and Scanning Electron Microscopy, showing a height of ~27.5 nm for the first bilayer and an overall height of ~165 nm for the (PAH/poly(MC-R))5 multilayer film. Prolonged white light irradiation (22h) showed a gradual decrease of the MC band by 90.4 ±2.9% relative to the baseline, indicating the potential application of these films as coatings for photo-controlled delivery systems.

Published
2018

32. Reversible photochromic polynorbornenes bearing spiropyran side groups for layer-by-layer coatings

Author

Florea, Larisa, Moloney, Cara, Nixon, David, Moulton, Simon E., Wallace, Gordon, Benito-Lopez, Fernando, and Diamond, Dermot

Subjects
Chemistry, Photochemistry, Organic chemistry
Abstract

A great number of stimuli-responsive materials have been reported in the recent years and they find applicability in fields ranging from optoelectronics, surface coatings, photonics and biomedicine. A particular attractive class of stimuli-responsive materials is comprised by photo-responsive materials as light is an environment-friendly stimulus and can be applied remotely, in a non-invasive manner. Photo-responsive materials have been the subject of many investigations over the past decade due to their potential applications, particularly in the design and development of memory devices, artificial muscles, soft-actuators and drug delivery, among others[1]. In the field of photo-responsive polymers, the layer-by-layer (LbL) approach offers a simple and effective method to fabricate uniform thin films capable of photo-modulation. In this context, we are focusing our investigations on the synthesis of LbL coatings based on new photochromic norbornenes polymers bearing spiropyran side groups. We have shown that these LbL coatings are capable of disassembling upon photostimulation. When used for the coating of microcapsules, these polymers have the ability to be used for photo-controlled drug delivery. [1] L. Florea, D. Diamond, F. Benito-Lopez, Macromol. Mater. Eng. 2012, 297, 1148.

Published
2015

33. Magnetic chromatography improves colloidal and MRI attributes of magnetoliposomes enabling evaluation of the impact of size on bio-distribution in an in vivo model of pancreatic cancer.

Author

Moloney C, Roy Chaudhuri T, Straubinger RM, and Brougham DF

Abstract

Magnetic chromatography was exploited to fractionate suspensions of magnetoliposomes (SML: lumen-free lipid-encapsulated clusters of multiple magnetic iron-oxide nanoparticles) improving their colloidal properties and relaxivity (magnetic resonance image contrast capability). Fractionation (i) removed sub-populations that do not contribute to the MRI response, and thus (ii) enabled evaluation of the size-dependence of relaxivity for the MRI-active part, which was surprisingly weak in the 55-90 nm range. MC was therefore implemented for processing multiple PEGylated SML types having average sizes ranging from 85 to 105 nm, which were then shown to have strongly size-dependent uptake in an in vivo pancreatic cancer model. Hence for applications in cancer diagnosis, selection of SML of suitable size for the biological target is more important than size-dependence of relaxivity.

Published
2025
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