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3. Supplementary Figures 1-7 & Supplementary Tables 1-4 from Transcriptomic Analysis of Diffuse Intrinsic Pontine Glioma (DIPG) Identifies a Targetable ALDH-Positive Subset of Highly Tumorigenic Cancer Stem-like Cells

Author

Surowiec, Rachel K., primary, Ferris, Sarah F., primary, Apfelbaum, April, primary, Espinoza, Carlos, primary, Mehta, Ranjit K., primary, Monchamp, Karamoja, primary, Sirihorachai, Veerin R., primary, Bedi, Karan, primary, Ljungman, Mats, primary, and Galban, Stefanie, primary

Published
2023
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4. Supplementary excel file from Transcriptomic Analysis of Diffuse Intrinsic Pontine Glioma (DIPG) Identifies a Targetable ALDH-Positive Subset of Highly Tumorigenic Cancer Stem-like Cells

Author

Surowiec, Rachel K., primary, Ferris, Sarah F., primary, Apfelbaum, April, primary, Espinoza, Carlos, primary, Mehta, Ranjit K., primary, Monchamp, Karamoja, primary, Sirihorachai, Veerin R., primary, Bedi, Karan, primary, Ljungman, Mats, primary, and Galban, Stefanie, primary

Published
2023
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5. Microfluidic concurrent assessment of red blood cell adhesion and microcapillary occlusion: potential hemorheological biomarkers in sickle cell disease

Author

Man, Yuncheng, primary, Wu, Douglas H., additional, An, Ran, additional, Wei, Peiran, additional, Monchamp, Karamoja, additional, Goreke, Utku, additional, Sekyonda, Zoe, additional, Wulftange, William J., additional, Federici, Chiara, additional, Bode, Allison, additional, Nayak, Lalitha V., additional, Little, Jane A., additional, and Gurkan, Umut A., additional

Published
2023
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7. OcclusionChip: A functional microcapillary occlusion assay complementary to ektacytometry for detection of small-fraction red blood cells with abnormal deformability

Author

Man, Yuncheng, primary, An, Ran, additional, Monchamp, Karamoja, additional, Sekyonda, Zoe, additional, Kucukal, Erdem, additional, Federici, Chiara, additional, Wulftange, William J., additional, Goreke, Utku, additional, Bode, Allison, additional, Sheehan, Vivien A., additional, and Gurkan, Umut A., additional

Published
2022
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8. Antithrombin‐III mitigates thrombin‐mediated endothelial cell contraction and sickle red blood cell adhesion in microscale flow

Author

Wulftange, William J., primary, Kucukal, Erdem, additional, Man, Yuncheng, additional, An, Ran, additional, Monchamp, Karamoja, additional, Sevrain, Charlotte D., additional, Dashora, Himanshu R., additional, Owusu‐Ansah, Amma T., additional, Bode, Allison, additional, Ilich, Anton, additional, Little, Jane A., additional, Key, Nigel S., additional, and Gurkan, Umut A., additional

Published
2022
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11. OcclusionChip: A functional microcapillary occlusion assay complementary to ektacytometry for detection of small-fraction red blood cells with abnormal deformability.

Author

Yuncheng Man, An, Ran, Monchamp, Karamoja, Sekyonda, Zoe, Kucukal, Erdem, Federici, Chiara, Wulftange, William J., Goreke, Utku, Bode, Allison, Sheehan, Vivien A., and Gurkan, Umut A.

Subjects
ERYTHROCYTES, SICKLE cell trait, SICKLE cell anemia, STEM cell transplantation, HEMATOPOIETIC stem cells
Abstract

Red blood cell (RBC) deformability is a valuable hemorheological biomarker that can be used to assess the clinical status and response to therapy of individuals with sickle cell disease (SCD). RBC deformability has been measured by ektacytometry for decades, which uses shear or osmolar stress. However, ektacytometry is a population based measurement that does not detect small-fractions of abnormal RBCs. A single cell-based, functional RBC deformability assay would complement ektacytometry and provide additional information. Here, we tested the relative merits of the OcclusionChip, which measures RBC deformability by microcapillary occlusion, and ektacytometry. We tested samples containing glutaraldehyde-stiffened RBCs for up to 1% volume fraction; ektacytometry detected no significant change in Elongation Index (EI), while the OcclusionChip showed significant differences in Occlusion Index (OI). OcclusionChip detected a significant increase in OI in RBCs from an individual with sickle cell trait (SCT) and from a subject with SCD who received allogeneic hematopoietic stem cell transplant (HSCT), as the sample was taken from normoxic (pO2:159 mmHg) to physiologic hypoxic (pO2:45 mmHg) conditions. Oxygen gradient ektacytometry detected no difference in EI for SCT or HSCT. These results suggest that the single cellbased OcclusionChip enables detection of sickle hemoglobin (HbS)-related RBC abnormalities in SCT and SCD, particularly when the HbS level is low. We conclude that the OcclusionChip is complementary to the population based ektacytometry assays, and providing additional sensitivity and capacity to detect modest abnormalities in red cell function or small populations of abnormal red cells. [ABSTRACT FROM AUTHOR]

Published
2022
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12. Transcriptomic Analysis of Diffuse Intrinsic Pontine Glioma (DIPG) Identifies a Targetable ALDH-Positive Subset of Highly Tumorigenic Cancer Stem-like Cells

Author

Surowiec, Rachel K., primary, Ferris, Sarah F., additional, Apfelbaum, April, additional, Espinoza, Carlos, additional, Mehta, Ranjit K., additional, Monchamp, Karamoja, additional, Sirihorachai, Veerin R., additional, Bedi, Karan, additional, Ljungman, Mats, additional, and Galban, Stefanie, additional

Published
2021
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