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3. A magnetic resonance imaging-based morphometric and structural covariance network study of Brazilian adolescents stratified by depression risk

Author

Rohrsetzer, Fernanda, Balardin, Joana Bisol, Picon, Felipe, Sato, João Ricardo, Battel, Lucas, Viduani, Anna, Manfro, Pedro Henrique, Yoon, Leehyun, Kohrt, Brandon A, Fisher, Helen L, Mondelli, Valeria, Swartz, Johnna R, and Kieling, Christian

Subjects
Paediatrics, Biomedical and Clinical Sciences, Depression, Brain Disorders, Biomedical Imaging, Pediatric, Clinical Research, Mental Illness, Neurosciences, Mental Health, Mental health, adolescent, depression, risk factors, methods, neuroimaging/structural, Adolescent, Clinical Sciences, Psychiatry, Clinical sciences, Clinical and health psychology
Abstract

ObjectiveTo explore differences in regional cortical morphometric structure between adolescents at risk for depression or with current depression.MethodsWe analyzed cross-sectional structural neuroimaging data from a sample of 150 Brazilian adolescents classified as low-risk (n=50) or high-risk for depression (n=50) or with current depression (n=50) through a vertex-based approach with measurements of cortical volume, surface area and thickness. Differences between groups in subcortical volumes and in the organization of networks of structural covariance were also explored.ResultsNo significant differences in brain structure between groups were observed in whole-brain vertex-wise cortical volume, surface area or thickness. Also, no significant differences in subcortical volume were observed between risk groups. In relation to the structural covariance network, there was an indication of an increase in the hippocampus betweenness centrality index in the high-risk group network compared to the low-risk and current depression group networks. However, this result was only statistically significant when applying false discovery rate correction for nodes within the affective network.ConclusionIn an adolescent sample recruited using an empirically based composite risk score, no major differences in brain structure were detected according to the risk and presence of depression.

Published
2023

5. Advancing precision psychiatry and targeted treatments: Insights from immunopsychiatry

Author

Miller, Andrew H., Berk, Michael, Bloch, Gilles, Briquet-Laugier, Veronique, Brouillon, Carinne, Cuthbert, Bruce N., Dantzer, Robert, Davis, Michael C., De Picker, Livia J., Drevets, Wayne C., Eyre, Harris A., Hack, Laura M., Harrison, Neil A., Krystal, Andrew D., Lombardo, Giulia, Mondelli, Valeria, Pariante, Carmine M., Pulvirenti, Luigi, Salvadore, Giacomo, Sforzini, Luca, Swieboda, Pawel, Trivedi, Madhukar H., and Leboyer, Marion

Published
2025
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9. Disturbed sex hormone milieu in males and females with major depressive disorder and low-grade inflammation

Author

Lombardo, Giulia, Mondelli, Valeria, Worrell, Courtney, Sforzini, Luca, Mariani, Nicole, Nikkheslat, Naghmeh, Nettis, Maria A., Kose, Melisa, Zajkowska, Zuzanna, Cattaneo, Annamaria, Pointon, Linda, Turner, Lorinda, Cowen, Philip J., Drevets, Wayne C., Cavanagh, Jonathan, Harrison, Neil A., Bullmore, Edward T., Dazzan, Paola, and Pariante, Carmine M.

Published
2024
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10. Prospective Follow-Up of Adolescents With and at Risk for Depression: Protocol and Methods of the Identifying Depression Early in Adolescence Risk Stratified Cohort Longitudinal Assessments

Author

Piccin, Jader, Viduani, Anna, Buchweitz, Claudia, Pereira, Rivka B., Zimerman, Aline, Amando, Guilherme R., Cosenza, Victor, Ferreira, Leonardo Z., McMahon, Natália A.G., Melo, Ramásio F., Richter, Danyella, Reckziegel, Frederico D.S., Rohrsetzer, Fernanda, Souza, Laila, Tonon, André C., Costa-Valle, Marina Tuerlinckx, Zajkowska, Zuzanna, Araújo, Ricardo Matsumura, Hauser, Tobias U., van Heerden, Alastair, Hidalgo, Maria Paz, Kohrt, Brandon A., Mondelli, Valeria, Swartz, Johnna R., Fisher, Helen L., and Kieling, Christian

Published
2024
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13. A systematic review of the association between biological markers and environmental stress risk factors for adolescent depression.

Author

Zajkowska, Zuzanna, Walsh, Annabel, Zonca, Valentina, Gullett, Nancy, Pedersen, Gloria, Kieling, Christian, Swartz, Johnna, Karmacharya, Rakesh, Fisher, Helen, Kohrt, Brandon, and Mondelli, Valeria

Subjects
Adolescence, Biomarkers, Brain, Child maltreatment, Cortisol, Depression, Early life adversity, Inflammation, MDD, MRI, Major depressive disorder, Risk factors, Young people, Youth, Adolescent, Biomarkers, Cross-Sectional Studies, Depression, Depressive Disorder, Major, Humans, Prospective Studies, Risk Factors, Young Adult
Abstract

INTRODUCTION: Although the aetiology and pathophysiology of depression are multifactorial, to date most studies have examined either biological or environmental mechanisms without looking at the integration of both; with most studies conducted in high-income countries (HICs). Therefore, we conducted a systematic review of worldwide studies investigating the relationship between biological and environmental stress risk factors for major depressive disorder (MDD) in adolescence. METHODS: We searched MEDLINE (via Ovid), PsycINFO, Cochrane Database of Systematic Reviews, Web of Science (Core Collection), Lilacs, African Journals Online and Global Health for prospective and cross-sectional studies that examined the association between biological markers and environmental stress risk factors in MDD during adolescence. FINDINGS: Of 11,089 articles identified, 21 were included, with only two from middle-income countries. Increased inflammation, telomere length and brain abnormalities, including blunted reward-related activity, white matter disruptions, and altered volume of limbic brain regions, were associated with increased risk for MDD mainly in the context of early life adversity. There is little evidence suggesting that the neurobiological changes investigated were associated with MDD in the context of recent life stress. INTERPRETATION: The developmental trajectory of depression appears to start with early life adversities and occurs in the context of immune and brain abnormalities. Understanding these biopsychosocial processes will help to improve our ability to detect individuals at risk of developing depression in adolescence. However, generalizability is limited by few studies examining both biological and environmental stress risk factors and a lack of studies on adolescents and young adults in low-and-middle-income countries (LMICs).

Published
2021

16. Mind the brain gap: The worldwide distribution of neuroimaging research on adolescent depression

Author

Battel, Lucas, Cunegatto, Fernanda, Viduani, Anna, Fisher, Helen L, Kohrt, Brandon A, Mondelli, Valeria, Swartz, Johnna R, and Kieling, Christian

Subjects
Biomedical and Clinical Sciences, Serious Mental Illness, Pediatric, Mental Health, Depression, Neurosciences, Mental Illness, Brain Disorders, 2.3 Psychological, social and economic factors, Mental health, Good Health and Well Being, Adolescent, Adolescent Behavior, Biomedical Research, Brain, Databases, Factual, Developing Countries, Global Health, Humans, Neuroimaging, Risk Factors, Adolescence, Income, Inequality, Developing countries, Medical and Health Sciences, Psychology and Cognitive Sciences, Neurology & Neurosurgery, Biomedical and clinical sciences, Health sciences
Abstract

Adolescents comprise one fourth of the world's population, with about 90% of them living in low- and middle-income countries (LMICs). The incidence of depression markedly increases during adolescence, making the disorder a leading cause of disease-related disability in this age group. However, most research on adolescent depression has been performed in high-income countries (HICs). To ascertain the extent to which this disparity operates in neuroimaging research, a systematic review of the literature was performed. A total of 148 studies were identified, with neuroimaging data available for 4,729 adolescents with depression. When stratified by income group, 122 (82%) studies originated from HICs, while 26 (18%) were conducted in LMICs, for a total of 3,705 and 1,024 adolescents with depression respectively. A positive Spearman rank correlation was observed between country per capita income and sample size (rs=0.673, p = 0.023). Our results support the previous reports showing a large disparity between the number of studies and the adolescent population per world region. Future research comparing neuroimaging findings across populations from HICs and LMICs may provide unique insights to enhance our understanding of the neurobiological processes underlying the development of depression.

Published
2021

18. The Identifying Depression Early in Adolescence Risk Stratified Cohort (IDEA-RiSCo): Rationale, Methods, and Baseline Characteristics

Author

Kieling, Christian, Buchweitz, Claudia, Caye, Arthur, Manfro, Pedro, Pereira, Rivka, Viduani, Anna, Anés, Maurício, Battel, Lucas, Benetti, Silvia, Fisher, Helen L, Karmacharya, Rakesh, Kohrt, Brandon A, Martini, Thais, Petresco, Sandra, Piccin, Jader, Rocha, Thiago, Rohde, Luis Augusto, Rohrsetzer, Fernanda, Souza, Laila, Velazquez, Bruna, Walsh, Annabel, Yoon, Leehyun, Zajkowska, Zuzanna, Zonca, Valentina, Swartz, Johnna R, and Mondelli, Valeria

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Behavioral and Social Science, Mental Health, Brain Disorders, Mental Illness, Serious Mental Illness, Clinical Research, Depression, Pediatric, Major Depressive Disorder, 4.2 Evaluation of markers and technologies, Mental health, Good Health and Well Being, depression, adolescence, risk score, cohort, neurobiology, Public Health and Health Services, Psychology, Clinical sciences
Abstract

Background: The characterization of adolescents at high risk for developing depression has traditionally relied on the presence or absence of single risk factors. More recently, the use of composite risk scores combining information from multiple variables has gained attention in prognostic research in the field of mental health. We previously developed a sociodemographic composite score to estimate the individual level probability of depression occurrence in adolescence, the Identifying Depression Early in Adolescence Risk Score (IDEA-RS). Objectives: In this report, we present the rationale, methods, and baseline characteristics of the Identifying Depression Early in Adolescence Risk Stratified Cohort (IDEA-RiSCo), a study designed for in-depth examination of multiple neurobiological, psychological, and environmental measures associated with the risk of developing and with the presence of depression in adolescence, with a focus on immune/inflammatory and neuroimaging markers. Methods: Using the IDEA-RS as a tool for risk stratification, we recruited a new sample of adolescents enriched for low (LR) and high (HR) depression risk, as well as a group of adolescents with a currently untreated major depressive episode (MDD). Methods for phenotypic, peripheral biological samples, and neuroimaging assessments are described, as well as baseline clinical characteristics of the IDEA-RiSCo sample. Results: A total of 7,720 adolescents aged 14-16 years were screened in public state schools in Porto Alegre, Brazil. We were able to identify individuals at low and high risk for developing depression in adolescence: in each group, 50 participants (25 boys, 25 girls) were included and successfully completed the detailed phenotypic assessment with ascertainment of risk/MDD status, blood and saliva collections, and magnetic resonance imaging (MRI) scans. Across a variety of measures of psychopathology and exposure to negative events, there was a clear pattern in which either the MDD group or both the HR and the MDD groups exhibited worse indicators in comparison to the LR group. Conclusion: The use of an empirically-derived composite score to stratify risk for developing depression represents a promising strategy to establish a risk-enriched cohort that will contribute to the understanding of the neurobiological correlates of risk and onset of depression in adolescence.

Published
2021

22. Gone Too Soon: priorities for action to prevent premature mortality associated with mental illness and mental distress

Author

O'Connor, Rory C, Worthman, Carol M, Abanga, Marie, Athanassopoulou, Nikoletta, Boyce, Niall, Chan, Lai Fong, Christensen, Helen, Das-Munshi, Jayati, Downs, James, Koenen, Karestan C, Moutier, Christine Yu, Templeton, Peter, Batterham, Philip, Brakspear, Karen, Frank, Richard G, Gilbody, Simon, Gureje, Oye, Henderson, David, John, Ann, Kabagambe, Wilbroad, Khan, Murad, Kessler, David, Kirtley, Olivia J, Kline, Sarah, Kohrt, Brandon, Lincoln, Alisa K, Lund, Crick, Mendenhall, Emily, Miranda, Regina, Mondelli, Valeria, Niederkrotenthaler, Thomas, Osborn, David, Pirkis, Jane, Pisani, Anthony R, Prawira, Benny, Rachidi, Hala, Seedat, Soraya, Siskind, Dan, Vijayakumar, Lakshmi, and Yip, Paul S F

Published
2023
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23. Serum immune markers and transition to psychosis in individuals at clinical high risk

Author

Mondelli, Valeria, Blackman, Graham, Kempton, Matthew J., Pollak, Thomas A., Iyegbe, Conrad, Valmaggia, Lucia R., Amminger, Paul, Barrantes-Vidal, Neus, Bressan, Rodrigo, van der Gaag, Mark, de Haan, Lieuwe, Krebs, Marie-Odile, Nordentoft, Merete, Ruhrmann, Stephan, Riecher-Rössler, Anita, Rutten, Bart P.F., Sachs, Gabriele, Koutsouleris, Nikolaos, and McGuire, Philip

Published
2023
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25. Neuroimaging adolescents with depression in a middle-income country: feasibility of an fMRI protocol and preliminary results

Author

Battel, Lucas, Swartz, Johnna, Anes, Mauricio, Manfro, Pedro H, Rohde, Luis A, Viduani, Anna, Mondelli, Valeria, and Kieling, Christian

Subjects
Biological Psychology, Biomedical and Clinical Sciences, Psychology, Clinical Research, Brain Disorders, Behavioral and Social Science, Biomedical Imaging, Basic Behavioral and Social Science, Major Depressive Disorder, Mental Health, Serious Mental Illness, Depression, Neurosciences, Pediatric, Mental health, Adolescent, Brazil, Cerebral Cortex, Depressive Disorder, Major, Feasibility Studies, Humans, Magnetic Resonance Imaging, Male, Neural Pathways, Neuroimaging, Neuropsychological Tests, Quality Control, Reproducibility of Results, Socioeconomic Factors, Surveys and Questionnaires, adolescent, neuroimaging, Clinical Sciences, Psychiatry, Clinical sciences, Clinical and health psychology
Abstract

ObjectiveTo test the feasibility and to present preliminary results of a neuroimaging protocol to evaluate adolescent depression in a middle-income setting.MethodsWe assessed psychotropic medication-free adolescents (age range 14-16 years) with a diagnosis of major depressive disorder (MDD). Participants underwent a comprehensive clinical evaluation and both structural and functional magnetic resonance imaging (fMRI). In this pilot study, a preliminary single-group analysis of resting-state fMRI (rs-fMRI) data was performed, with a focus on the default mode network (DMN), cognitive control network (CCN), and salience network (SN).ResultsThe sample included 29 adolescents with MDD (mean age 16.01, SD 0.78) who completed the protocol. Only two participants were excluded due to MRI quality issues (head movement), and were not included in the analyses. The scans showed significant connectivity between the medial prefrontal cortex and posterior cingulate cortex (DMN), the ACC and anterior insula (SN), and the lateral prefrontal cortex and dorsal parietal cortex (CCN).ConclusionWe demonstrated the feasibility of implementing a complex neuroimaging protocol in a middle-income country. Further, our preliminary rs-fMRI data revealed patterns of resting-state connectivity consistent with prior research performed in adolescents from high-income countries.

Published
2020

26. Protocol for a systematic review of the development of depression among adolescents and young adults: psychological, biological, and contextual perspectives around the world

Author

Pedersen, Gloria A, Zajkowska, Zuzanna, Kieling, Christian, Gautam, Kamal, Mondelli, Valeria, Fisher, Helen L, Swartz, Johnna R, Adewuya, Abiodun, Karmacharya, Rakesh, and Kohrt, Brandon A

Subjects
Paediatrics, Biomedical and Clinical Sciences, Clinical Sciences, Prevention, Mental Health, Depression, Clinical Research, Behavioral and Social Science, 2.3 Psychological, social and economic factors, Aetiology, Mental health, Good Health and Well Being, Adolescent, Adult, Developed Countries, Developing Countries, Global Health, Humans, Risk Factors, Socioeconomic Factors, Young Adult, Young adult, Risk factors, Protective factors, Early diagnosis, Developing countries, Neurosciences, Review, Risk assessment, Medical and Health Sciences, Biomedical and clinical sciences, Health sciences
Abstract

BackgroundDepression is a leading contributor to disability-adjusted life-years because of early onset and chronicity throughout the lifecycle. It is crucial to identify early predictors of depression among adolescents and young people to effectively target prevention. A gap in the literature is a comprehensive systematic review of predictors of depression among adolescents around the globe, especially in low- and middle-income countries LMICs. This review aims to identify evidence for biological, psychological, and contextual risk factors for the development of depression among adolescents and young adults (10-24 years of age) in high-income countries (HICs) and LMICs, ultimately contributing to (a) identification of potential mechanisms underlying depression development, (b) selection of common risk and protective factors as targets for detection, and (c) refinement of risk models that can be evaluated through existing cohorts in HICs and LMICs.MethodsThis review will follow the Population, Exposure, Comparison, Outcome (PI(E)CO) model and adheres to the PRISMA-P guidelines. A search strategy was developed by a multidisciplinary research consortium. Seven databases (MEDLINE via Ovid, PsycINFO, Cochrane Database of Systematic Reviews, Web of Science, Lilacs, African Journals Online, Global Health) will be searched to identify articles. Independent raters will screen and retrieve articles for inclusion, conduct quality ratings, and extract data. The Systematic Assessment of Quality in Observational Research adapted for Cultural Psychiatry Epidemiology (SAQOR-CPE) will be used to assess quality of observational studies. We will assess for publication bias using funnel plots and statistical methods. We will use narrative synthesis to present results, addressing the study's objectives following the Cochrane Handbook guidelines. Meta-analyses will be used to report summary statistics for association of risk factors with development of depression.DiscussionThis systematic review will summarize evidence-based research that examines the psychological, biological, and contextual factors contributing to the onset of depression in adolescents across the globe. Results will support the development of a model that can be evaluated in existing cohorts around the world.Systematic review registrationPROSPERO registration CRD42018103973 .

Published
2019

28. Sex differences in a double-blind randomized clinical trial with minocycline in treatment-resistant depressed patients: CRP and IL-6 as sex-specific predictors of treatment response

Author

Lombardo, Giulia, Nettis, Maria Antonietta, Hastings, Caitlin, Zajkowska, Zuzanna, Mariani, Nicole, Nikkheslat, Naghmeh, Worrell, Courtney, Enache, Daniela, McLaughlin, Anna, Kose, Melisa, Bogdanova, Anna, Sforzini, Luca, Cleare, Anthony J., Young, Allan H., Dazzan, Paola, Mondelli, Valeria, and Pariante, Carmine M.

Published
2022
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31. Extra-axial inflammatory signal and its relationship to peripheral and central immunity in depression.

Author

Eiff, Brandi, Bullmore, Edward T, Clatworthy, Menna R, Fryer, Tim D, Pariante, Carmine M, Mondelli, Valeria, Maccioni, Lucia, Hadjikhani, Nouchine, Loggia, Marco L, Moskowitz, Michael A, Bruner, Emiliano, Veronese, Mattia, Turkheimer, Federico E, and Schubert, Julia J

Subjects
OCCIPITAL bone, POSITRON emission tomography, BIOMARKERS, TRANSLOCATOR proteins, BONE marrow
Abstract

Although both central and peripheral inflammation have been observed consistently in depression, the relationship between the two remains obscure. Extra-axial immune cells may play a role in mediating the connection between central and peripheral immunity. This study investigates the potential roles of calvarial bone marrow and parameningeal spaces in mediating interactions between central and peripheral immunity in depression. PET was used to measure regional TSPO expression in the skull and parameninges as a marker of inflammatory activity. This measure was correlated with brain TSPO expression and peripheral cytokine concentrations in a cohort enriched for heightened peripheral and central immunity comprising 51 individuals with depression and 25 healthy controls. The findings reveal a complex relationship between regional skull TSPO expression and both peripheral and central immunity. Facial and parietal skull bone TSPO expression showed significant associations with both peripheral and central immunity. TSPO expression in the confluence of sinuses was also linked to both central and peripheral immune markers. Group-dependent elevations in TSPO expression within the occipital skull bone marrow were also found to be significantly associated with central inflammation. Significant associations between immune activity within the skull, parameninges, parenchyma and periphery highlight the role of the skull bone marrow and venous sinuses as pivotal sites for peripheral and central immune interactions. [ABSTRACT FROM AUTHOR]

Published
2025
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32. Associations between perceived parenting, brain activity and connectivity, and depression symptoms in Brazilian adolescents.

Author

Carranza, Angelica F., Yoon, Leehyun, Rohrsetzer, Fernanda, Battel, Lucas, Manfro, Pedro H., Rohde, Luis A., Viduani, Anna, Zajkowska, Zuzanna, Mondelli, Valeria, Kieling, Christian, and Swartz, Johnna R.

Subjects
PARENTING, DEPRESSION in adolescence, BRAIN function localization, FUNCTIONAL magnetic resonance imaging
Abstract

In adolescence, parental care is associated with lower depression symptoms whereas parental overprotection is associated with greater depression symptoms, effects which may be mediated by adolescent brain activity and connectivity. The present study examined associations between perceived parenting, brain activity and connectivity, and depression symptoms in adolescents from Brazil, a middle-income country (MIC). Analyses included 100 adolescents who underwent functional magnetic resonance imaging scanning while completing a face matching task. Parental care and overprotection were associated with adolescent depression symptoms in expected directions. We also found that parental care and overprotection were associated with amygdala connectivity with several brain regions; however, amygdala activity was not associated with parenting and neither activity or connectivity mediated the association between parenting and depression symptoms. Results identify how parenting influences brain function and depression symptoms in youth from a MIC. [ABSTRACT FROM AUTHOR]

Published
2024
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34. Mapping genomic loci implicates genes and synaptic biology in schizophrenia

Author

Trubetskoy, Vassily, Pardiñas, Antonio F., Qi, Ting, Panagiotaropoulou, Georgia, Awasthi, Swapnil, Bigdeli, Tim B., Bryois, Julien, Chen, Chia-Yen, Dennison, Charlotte A., Hall, Lynsey S., Lam, Max, Watanabe, Kyoko, Frei, Oleksandr, Ge, Tian, Harwood, Janet C., Koopmans, Frank, Magnusson, Sigurdur, Richards, Alexander L., Sidorenko, Julia, Wu, Yang, Zeng, Jian, Grove, Jakob, Kim, Minsoo, Li, Zhiqiang, Voloudakis, Georgios, Zhang, Wen, Adams, Mark, Agartz, Ingrid, Atkinson, Elizabeth G., Agerbo, Esben, Al Eissa, Mariam, Albus, Margot, Alexander, Madeline, Alizadeh, Behrooz Z., Alptekin, Köksal, Als, Thomas D., Amin, Farooq, Arolt, Volker, Arrojo, Manuel, Athanasiu, Lavinia, Azevedo, Maria Helena, Bacanu, Silviu A., Bass, Nicholas J., Begemann, Martin, Belliveau, Richard A., Bene, Judit, Benyamin, Beben, Bergen, Sarah E., Blasi, Giuseppe, Bobes, Julio, Bonassi, Stefano, Braun, Alice, Bressan, Rodrigo Affonseca, Bromet, Evelyn J., Bruggeman, Richard, Buckley, Peter F., Buckner, Randy L., Bybjerg-Grauholm, Jonas, Cahn, Wiepke, Cairns, Murray J., Calkins, Monica E., Carr, Vaughan J., Castle, David, Catts, Stanley V., Chambert, Kimberley D., Chan, Raymond C. K., Chaumette, Boris, Cheng, Wei, Cheung, Eric F. C., Chong, Siow Ann, Cohen, David, Consoli, Angèle, Cordeiro, Quirino, Costas, Javier, Curtis, Charles, Davidson, Michael, Davis, Kenneth L., de Haan, Lieuwe, Degenhardt, Franziska, DeLisi, Lynn E., Demontis, Ditte, Dickerson, Faith, Dikeos, Dimitris, Dinan, Timothy, Djurovic, Srdjan, Duan, Jubao, Ducci, Giuseppe, Dudbridge, Frank, Eriksson, Johan G., Fañanás, Lourdes, Faraone, Stephen V., Fiorentino, Alessia, Forstner, Andreas, Frank, Josef, Freimer, Nelson B., Fromer, Menachem, Frustaci, Alessandra, Gadelha, Ary, Genovese, Giulio, Gershon, Elliot S., Giannitelli, Marianna, Giegling, Ina, Giusti-Rodríguez, Paola, Godard, Stephanie, Goldstein, Jacqueline I., González Peñas, Javier, González-Pinto, Ana, Gopal, Srihari, Gratten, Jacob, Green, Michael F., Greenwood, Tiffany A., Guillin, Olivier, Gülöksüz, Sinan, Gur, Raquel E., Gur, Ruben C., Gutiérrez, Blanca, Hahn, Eric, Hakonarson, Hakon, Haroutunian, Vahram, Hartmann, Annette M., Harvey, Carol, Hayward, Caroline, Henskens, Frans A., Herms, Stefan, Hoffmann, Per, Howrigan, Daniel P., Ikeda, Masashi, Iyegbe, Conrad, Joa, Inge, Julià, Antonio, Kähler, Anna K., Kam-Thong, Tony, Kamatani, Yoichiro, Karachanak-Yankova, Sena, Kebir, Oussama, Keller, Matthew C., Kelly, Brian J., Khrunin, Andrey, Kim, Sung-Wan, Klovins, Janis, Kondratiev, Nikolay, Konte, Bettina, Kraft, Julia, Kubo, Michiaki, Kučinskas, Vaidutis, Kučinskiene, Zita Ausrele, Kusumawardhani, Agung, Kuzelova-Ptackova, Hana, Landi, Stefano, Lazzeroni, Laura C., Lee, Phil H., Legge, Sophie E., Lehrer, Douglas S., Lencer, Rebecca, Lerer, Bernard, Li, Miaoxin, Lieberman, Jeffrey, Light, Gregory A., Limborska, Svetlana, Liu, Chih-Min, Lönnqvist, Jouko, Loughland, Carmel M., Lubinski, Jan, Luykx, Jurjen J., Lynham, Amy, Macek, Jr, Milan, Mackinnon, Andrew, Magnusson, Patrik K. E., Maher, Brion S., Maier, Wolfgang, Malaspina, Dolores, Mallet, Jacques, Marder, Stephen R., Marsal, Sara, Martin, Alicia R., Martorell, Lourdes, Mattheisen, Manuel, McCarley, Robert W., McDonald, Colm, McGrath, John J., Medeiros, Helena, Meier, Sandra, Melegh, Bela, Melle, Ingrid, Mesholam-Gately, Raquelle I., Metspalu, Andres, Michie, Patricia T., Milani, Lili, Milanova, Vihra, Mitjans, Marina, Molden, Espen, Molina, Esther, Molto, María Dolores, Mondelli, Valeria, Moreno, Carmen, Morley, Christopher P., Muntané, Gerard, Murphy, Kieran C., Myin-Germeys, Inez, Nenadić, Igor, Nestadt, Gerald, Nikitina-Zake, Liene, Noto, Cristiano, Nuechterlein, Keith H., O’Brien, Niamh Louise, O’Neill, F. Anthony, Oh, Sang-Yun, Olincy, Ann, Ota, Vanessa Kiyomi, Pantelis, Christos, Papadimitriou, George N., Parellada, Mara, Paunio, Tiina, Pellegrino, Renata, Periyasamy, Sathish, Perkins, Diana O., Pfuhlmann, Bruno, Pietiläinen, Olli, Pimm, Jonathan, Porteous, David, Powell, John, Quattrone, Diego, Quested, Digby, Radant, Allen D., Rampino, Antonio, Rapaport, Mark H., Rautanen, Anna, Reichenberg, Abraham, Roe, Cheryl, Roffman, Joshua L., Roth, Julian, Rothermundt, Matthias, Rutten, Bart P. F., Saker-Delye, Safaa, Salomaa, Veikko, Sanjuan, Julio, Santoro, Marcos Leite, Savitz, Adam, Schall, Ulrich, Scott, Rodney J., Seidman, Larry J., Sharp, Sally Isabel, Shi, Jianxin, Siever, Larry J., Sigurdsson, Engilbert, Sim, Kang, Skarabis, Nora, Slominsky, Petr, So, Hon-Cheong, Sobell, Janet L., Söderman, Erik, Stain, Helen J., Steen, Nils Eiel, Steixner-Kumar, Agnes A., Stögmann, Elisabeth, Stone, William S., Straub, Richard E., Streit, Fabian, Strengman, Eric, Stroup, T. Scott, Subramaniam, Mythily, Sugar, Catherine A., Suvisaari, Jaana, Svrakic, Dragan M., Swerdlow, Neal R., Szatkiewicz, Jin P., Ta, Thi Minh Tam, Takahashi, Atsushi, Terao, Chikashi, Thibaut, Florence, Toncheva, Draga, Tooney, Paul A., Torretta, Silvia, Tosato, Sarah, Tura, Gian Battista, Turetsky, Bruce I., Üçok, Alp, Vaaler, Arne, van Amelsvoort, Therese, van Winkel, Ruud, Veijola, Juha, Waddington, John, Walter, Henrik, Waterreus, Anna, Webb, Bradley T., Weiser, Mark, Williams, Nigel M., Witt, Stephanie H., Wormley, Brandon K., Wu, Jing Qin, Xu, Zhida, Yolken, Robert, Zai, Clement C., Zhou, Wei, Zhu, Feng, Zimprich, Fritz, Atbaşoğlu, Eşref Cem, Ayub, Muhammad, Benner, Christian, Bertolino, Alessandro, Black, Donald W., Bray, Nicholas J., Breen, Gerome, Buccola, Nancy G., Byerley, William F., Chen, Wei J., Cloninger, C. Robert, Crespo-Facorro, Benedicto, Donohoe, Gary, Freedman, Robert, Galletly, Cherrie, Gandal, Michael J., Gennarelli, Massimo, Hougaard, David M., Hwu, Hai-Gwo, Jablensky, Assen V., McCarroll, Steven A., Moran, Jennifer L., Mors, Ole, Mortensen, Preben B., Müller-Myhsok, Bertram, Neil, Amanda L., Nordentoft, Merete, Pato, Michele T., Petryshen, Tracey L., Pirinen, Matti, Pulver, Ann E., Schulze, Thomas G., Silverman, Jeremy M., Smoller, Jordan W., Stahl, Eli A., Tsuang, Debby W., Vilella, Elisabet, Wang, Shi-Heng, Xu, Shuhua, Adolfsson, Rolf, Arango, Celso, Baune, Bernhard T., Belangero, Sintia Iole, Børglum, Anders D., Braff, David, Bramon, Elvira, Buxbaum, Joseph D., Campion, Dominique, Cervilla, Jorge A., Cichon, Sven, Collier, David A., Corvin, Aiden, Curtis, David, Forti, Marta Di, Domenici, Enrico, Ehrenreich, Hannelore, Escott-Price, Valentina, Esko, Tõnu, Fanous, Ayman H., Gareeva, Anna, Gawlik, Micha, Gejman, Pablo V., Gill, Michael, Glatt, Stephen J., Golimbet, Vera, Hong, Kyung Sue, Hultman, Christina M., Hyman, Steven E., Iwata, Nakao, Jönsson, Erik G., Kahn, René S., Kennedy, James L., Khusnutdinova, Elza, Kirov, George, Knowles, James A., Krebs, Marie-Odile, Laurent-Levinson, Claudine, Lee, Jimmy, Lencz, Todd, Levinson, Douglas F., Li, Qingqin S., Liu, Jianjun, Malhotra, Anil K., Malhotra, Dheeraj, McIntosh, Andrew, McQuillin, Andrew, Menezes, Paulo R., Morgan, Vera A., Morris, Derek W., Mowry, Bryan J., Murray, Robin M., Nimgaonkar, Vishwajit, Nöthen, Markus M., Ophoff, Roel A., Paciga, Sara A., Palotie, Aarno, Pato, Carlos N., Qin, Shengying, Rietschel, Marcella, Riley, Brien P., Rivera, Margarita, Rujescu, Dan, Saka, Meram C., Sanders, Alan R., Schwab, Sibylle G., Serretti, Alessandro, Sham, Pak C., Shi, Yongyong, St Clair, David, Stefánsson, Hreinn, Stefansson, Kari, Tsuang, Ming T., van Os, Jim, Vawter, Marquis P., Weinberger, Daniel R., Werge, Thomas, Wildenauer, Dieter B., Yu, Xin, Yue, Weihua, Holmans, Peter A., Pocklington, Andrew J., Roussos, Panos, Vassos, Evangelos, Verhage, Matthijs, Visscher, Peter M., Yang, Jian, Posthuma, Danielle, Andreassen, Ole A., Kendler, Kenneth S., Owen, Michael J., Wray, Naomi R., Daly, Mark J., Huang, Hailiang, Neale, Benjamin M., Sullivan, Patrick F., Ripke, Stephan, Walters, James T. R., and O’Donovan, Michael C.

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2022
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40. A Modest Increase in 11C-PK11195-Positron Emission Tomography TSPO Binding in Depression Is Not Associated With Serum C-Reactive Protein or Body Mass Index

Author

Wlazly, Dominika, Dickinson, Amber, Foster, Andy, Knight, Clare, Leckey, Claire, Morgan, Paul, Morgan, Angharad, O'Hagan, Caroline, Touchard, Samuel, Khan, Shahid, Murphy, Phil, Parker, Christine, Patel, Jai, Richardson, Jill, Acton, Paul, Austin, Nigel, Bhattacharya, Anindya, Carruthers, Nick, de Boer, Peter, Drevets, Wayne, Isaac, John, Jones, Declan, Kemp, John, Kolb, Hartmuth, Nye, Jeff, Wittenberg, Gayle, Barker, Gareth, Bogdanova, Anna, Byrom, Heidi, Cash, Diana, Cattaneo, Annamaria, Enache, Daniela, Gee, Tony, Hastings, Caitlin, Kose, Melisa, Lombardo, Giulia, Mariani, Nicole, McLaughlin, Anna, Mondelli, Valeria, Nettis, Maria, Nikkheslat, Naghmeh, Pariante, Carmine, Randall, Karen, Schubert, Julia, Sforzini, Luca, Sheridan, Hannah, Simmons, Camilla, Singh, Nisha, Turkheimer, Federico, Van Loo, Vicky, Veronese, Mattia, Rodriguez, Marta Vicente, Wood, Toby, Worrell, Courtney, Zajkowska, Zuzanna, Campbell, Brian, Egebjerg, Jan, Eriksson, Hans, Gastambide, Francois, Adams, Karen Husted, Jeggo, Ross, Moeller, Thomas, Nelson, Bob, Plath, Niels, Thomsen, Christian, Pederson, Jan Torleif, Zorn, Stevin, Deith, Catherine, Farmer, Scott, McClean, John, McPherson, Andrew, Penandes, Nagore, Scouller, Paul, Sutherland, Murray, Attenburrow, Mary Jane, Benjamin, Jithen, Jones, Helen, Mada, Fran, Oladejo, Akintayo, Smith, Katy, Balice-Gordon, Rita, Binneman, Brendon, Duerr, James, Fullerton, Terence, Goli, Veeru, Hughes, Zoe, Piro, Justin, Samad, Tarek, Sporn, Jonathan, Hoskins, Liz, Kohn, Charmaine, Wilcock, Lauren, Aigbirhio, Franklin, Bhatti, Junaid, Bullmore, Ed, Chamberlain, Sam, Correia, Marta, Crofts, Anna, Fryer, Tim, Graves, Martin, Hatton, Alex, Kitzbichler, Manfred, Lynall, Mary-Ellen, Maurice, Christina, O'Donnell, Ciara, Pointon, Linda, St George Hyslop, Peter, Turner, Lorinda, Vertes, Petra, Widmer, Barry, Williams, Guy, Cavanagh, Jonathan, McColl, Alison, Shaw, Robin, Boddeke, Erik, Baird, Alison, Clare, Stuart, Cowen, Phil, Huang, I-Shu (Dante), Hurley, Sam, Lovestone, Simon, Nevado-Holgado, Alejo, Ribe, Elena, Vyas, Anviti, Winchester, Laura, Cleal, Madeleine, Gomez-Nicola, Diego, Mancuso, Renzo, Perry, Hugh, Cercignani, Mara, Clarke, Charlotte, Colasanti, Alessandro, Harrison, Neil, Murray, Rosemary, O'Connor, Jason, Mount, Howard, Schubert, Julia J., Fryer, Tim D., Manavaki, Roido, Kitzbichler, Manfred G., Nettis, Maria A., Pariante, Carmine M., Bullmore, Edward T., and Turkheimer, Federico E.

Published
2021
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44. Identifying Adolescents at Risk for Depression: A Prediction Score Performance in Cohorts Based in 3 Different Continents

Author

Rocha, Thiago Botter-Maio, Fisher, Helen L., Caye, Arthur, Anselmi, Luciana, Arseneault, Louise, Barros, Fernando C., Caspi, Avshalom, Danese, Andrea, Gonçalves, Helen, Harrington, Hona Lee, Houts, Renate, Menezes, Ana M.B., Moffitt, Terrie E., Mondelli, Valeria, Poulton, Richie, Rohde, Luis Augusto, Wehrmeister, Fernando, and Kieling, Christian

Published
2021
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