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2. Associations of exposure to outdoor PM2.5 and NO2 during pregnancy with childhood asthma, rhinitis, and eczema in a predominantly rural French mother-child cohort

Author

Patlán-Hernández, Alan R., Savouré, Marine, Audureau, Etienne, Monfort, Christine, de Castro, Montserrat, Epaud, Ralph, de Hoogh, Kees, Hough, Ian, Kloog, Itai, Lanone, Sophie, Lepeule, Johanna, Nieuwenhuijsen, Mark, Vienneau, Danielle, Warembourg, Charline, Chevrier, Cécile, and Jacquemin, Bénédicte

Published
2024
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10. Prenatal exposure to multiple persistent organic pollutants in association with adiposity markers and blood pressure in preadolescents

Author

Rouxel, Elke, Costet, Nathalie, Monfort, Christine, Audouze, Karine, Cirugeda, Lourdes, Gaudreau, Eric, Grimalt, Joan O., Ibarluzea, Jesus, Lainé, Fabrice, Llop, Sabrina, Lopez-Espinosa, Maria-Jose, Rouget, Florence, Santa-Marina, Loreto, Vrijheid, Martine, Chevrier, Cécile, Casas, Maribel, and Warembourg, Charline

Published
2023
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12. Prenatal Exposure to Perfluoroalkyl Substances and Child Behavior at Age 12: A PELAGIE Mother-Child Cohort Study

Author

Tillaut, Helene, Monfort, Christine, Rouget, Florence, Pele, Fabienne, Laine, Fabrice, Gaudreau, Eric, Cordier, Sylvaine, Warembourg, Charline, Saint-Amour, Dave, and Chevrier, Cecile

Subjects
Ammonium perfluorooctanoate, Pregnancy -- Behavior, Children -- Behavior -- Health aspects, Pregnant women, Environmental issues, Health
Abstract

Background: Per- and polyfluoroalkyl substances (PFAS) are chemical substances spread throughout the environment worldwide. Exposure during pregnancy represents a specific window of vulnerability for child health. Objective: Our objective was to assess the impact of prenatal exposure to multiple PFAS on emotional and behavioral functions in 12-y-old children. Method: In the PELAGIE mother-child cohort (France), prenatal exposure to nine PFAS was measured from concentrations in cord serum samples. Behavior was assessed at age 12 y using the parent-reported Strengths and Difficulties Questionnaire (SDQ) and the self-reported Dominic Interactive for Adolescents (DIA) for 444 children. Associations were estimated using negative binomial models for each PFAS. Bayesian kernel machine regression (BKMR) models were performed to assess the exposure mixture effect on children's behavior. Results: In our study population, 73% of mothers had spent more than 12 y in education. Higher scores on SDQ externalizing subscale were observed with increasing cord-serum concentration of perfluorooctanoic acid (PFOA) and perfluorononanoic acid (PFNA) [adjusted mean ratio (aMR) = 1.18, 95% confidence interval (CI): 1.03, 1.34, and aMR=1.14 (95% CI: 1.00, 1.29) for every doubling of concentration, respectively]. Results for the hyperactivity score were similar [aMR = 1.20 (95% CI: 1.04, 1.40) and aMR = 1.18 (95% CI: 1.02, 1.36), respectively]. With regard to major depressive disorder and internalizing subscales, perfluorodecanoic acid (PFDA) was associated with higher self- reported DIA scores [aMR= 1.14 (95% CI: 1.01, 1.27) and aMR= 1.11 (95% CI: 1.02, 1.21), respectively]. In terms of the anxiety subscale, PFDA and PFNA were associated with higher scores [aMR = 1.11 (95% CI: 1.02, 1.21) and aMR = 1.10 (95% CI: 1.01, 1.19), respectively]. Concurrent increases in the PFAS concentrations included in the BKMR models showed no change in the SDQ externalizing and DIA internalizing subscales scores. Conclusion: Prenatal exposure to PFNA and PFOA were associated with increasing scores for measures of externalizing behaviors, specifically hyperactivity. We also identified associations between PFNA and PFDA prenatal exposure levels and increasing scores related to internalizing behaviors (general anxiety and major depressive disorder), which adds to the as yet sparse literature examining the links between prenatal exposure to PFAS and internalizing disorders. https://doi.org/10.1289/EHP12540, Introduction Per- and polyfluoroalkyl substances (PFAS) form a group of more than 9,000 synthetic chemicals that have been used worldwide for more than 70 y. Their surfactant properties have ensured [...]

Published
2023
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18. Prenatal Exposure to Glycol Ethers and Neurocognitive Abilities in 6-Year-Old Children: The PELAGIE Cohort Study

Author

Béranger, Rémi, Garlantézec, Ronan, Le Maner-Idrissi, Gaïd, Lacroix, Agnès, Rouget, Florence, Trowbridge, Jessica, Warembourg, Charline, Monfort, Christine, Le Gléau, Florent, Jourdin, Marylène, Multigner, Luc, Cordier, Sylvaine, and Chevrier, Cécile

Subjects
Reproductive Medicine, Biomedical and Clinical Sciences, Neurosciences, Pediatric, Clinical Research, Reproductive health and childbirth, Child, Ethers, Ethylene Glycols, Female, France, Glycols, Hazardous Substances, Humans, Intelligence Tests, Male, Maternal Exposure, Neuropsychological Tests, Pregnancy, Prenatal Exposure Delayed Effects, Solvents, Wechsler Scales, Environmental Sciences, Medical and Health Sciences, Toxicology, Biomedical and clinical sciences, Environmental sciences, Health sciences
Abstract

BackgroundGlycol ethers (GE) are widely used organic solvents. Despite the potential neurotoxicity of several families of organic solvents, little is known about the impact of GE on the neurodevelopment of infants and children.ObjectivesWe investigated the relation between urinary concentrations of GE metabolites in pregnant women and neurocognitive abilities in their 6-year-old children in the PELAGIE mother-child cohort.MethodsFive GE metabolites were measured in first morning void urine samples of 204 French pregnant women in early pregnancy (< 19 weeks of gestation). Psychologists assessed the neurocognitive abilities of their 6-year-old children with the Wechsler Intelligence Scale for Children IV (WISC) and the Developmental Neuropsychological Assessment (NEPSY). We analyzed the results with linear (WISC) and Poisson regression models (NEPSY), adjusted for potential confounders, including child's stimulation at home.ResultsGE metabolites were detected in 90-100% of maternal urine samples. The WISC Verbal Comprehension score was significantly lower for children with the highest tertile of urinary phenoxyacetic acid (PhAA) [β (third vs. first tertile) = -6.53; 95% CI: -11.44, -1.62]. Similarly, the NEPSY Design Copying subtest score was lower in those with the highest tertile of urinary ethoxyacetic acid (EAA) [β (third vs. first tertile) = -0.11; 95% CI: -0.21, 0.00]. The other GE metabolites we studied were not significantly associated with WISC or NEPSY scores.ConclusionsPrenatal urine concentrations of two GE metabolites were associated with lower WISC Verbal Comprehension Index scores and NEPSY Design Copying subscale scores, respectively, at age 6 years. PhAA is the primary metabolite of 2-phenoxyethanol (EGPhE), which is commonly found in cosmetics, and precursors of EAA are frequently used in cleaning agents. Additional research is needed to confirm our findings and further explore potential effects of prenatal GE exposures on neurocognitive performance in children.

Published
2017

20. Comment créer et animer SA COMMUNAUTÉ DE CLIENTS?

Author

Monfort, Christine

Subjects
KEY performance indicators (Management), BRAND name products, SUCCESS, SCHEDULING
Abstract

Copyright of Marketing Magazine (France) is the property of Netmedia Group and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Published
2024

21. Régies digitales LE BON MIX.

Author

Monfort, Christine

Subjects
PERIODICAL publishing, DIGITAL media, ARTIFICIAL intelligence, ELECTRONIC commerce, ADVERTISING, BRAND name products
Abstract

Copyright of Marketing Magazine (France) is the property of Netmedia Group and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Published
2024

28. Cohort Profile: The PELAGIE mother-child cohort.

Author

Warembourg, Charline, Monfort, Christine, Costet, Nathalie, Rouget, Florence, Pelé, Fabienne, Garlantézec, Ronan, Cordier, Sylvaine, and Chevrier, Cécile

Subjects
*ATRAZINE, *PREGNANCY, *WHEEZE, *WECHSLER Intelligence Scale for Children, *PERSISTENT pollutants, *CONTINUOUS performance test, *WECHSLER Adult Intelligence Scale
Abstract

The PELAGIE mother-child cohort study, conducted in western France, aims to examine the impact of prenatal exposure to chemicals on pregnancy outcomes and child health. The study followed over 3,000 pregnant women and their newborns, collecting extensive data on chemical exposures and various health outcomes. The cohort is part of a European network and welcomes collaborations. The study found associations between prenatal exposure to solvents, pesticides, and persistent organic pollutants and adverse health effects in children. The data collected is available for further research. [Extracted from the article]

Published
2024
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37. Quelles innovations du côté des MMARARTECH ?

Author

Monfort, Christine

Subjects
DATA management, COOKIES (Computer science), MARKETING, ARTIFICIAL intelligence, PENCILS, ADVERTISING management
Abstract

Copyright of Marketing Magazine (France) is the property of Netmedia Group and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Published
2024

39. Prenatal exposure to multiple persistent organic pollutants in association with adiposity markers and blood pressure in preadolescents

Author

European Commission, 0000-0003-4277-818X, 0000-0001-7525-4089, 0000-0003-1095-5137, 0000-0002-3326-2459, 0000-0002-7391-5768, 0000-0002-6933-5373, 0000-0003-1405-9751, 0000-0002-2112-6740, 0000-0003-2716-9167, Rouxel, Elke, Costet, Nathalie, Monfort, Christine, Audouze, Karine, Cirugeda, Lourdes, Gaudreau, Eric, Grimalt, Joan O., Ibarluzea, Jesús, Lainé, Fabrice, Llop, Sabrina, Lopez-Espinosa, Maria-Jose, Rouget, Florence, Santa-Marina, Loreto, Vrijheid, Martine, Chevrier, Cécile, Casas, Maribel, Warembourg, Charline, European Commission, 0000-0003-4277-818X, 0000-0001-7525-4089, 0000-0003-1095-5137, 0000-0002-3326-2459, 0000-0002-7391-5768, 0000-0002-6933-5373, 0000-0003-1405-9751, 0000-0002-2112-6740, 0000-0003-2716-9167, Rouxel, Elke, Costet, Nathalie, Monfort, Christine, Audouze, Karine, Cirugeda, Lourdes, Gaudreau, Eric, Grimalt, Joan O., Ibarluzea, Jesús, Lainé, Fabrice, Llop, Sabrina, Lopez-Espinosa, Maria-Jose, Rouget, Florence, Santa-Marina, Loreto, Vrijheid, Martine, Chevrier, Cécile, Casas, Maribel, and Warembourg, Charline

Abstract

Several studies have reported that prenatal exposure to some persistent organic pollutants (POPs) is associated with higher adiposity in childhood. Few studies have assessed whether this finding persists into adolescence, and few have considered exposure to POPs as a mixture. This study aims to assess the association between prenatal exposure to multiple POPs and adiposity markers and blood pressure in preadolescents.

Published
2023

46. Persistent Organic Pollutant Exposure and Thyroid Function among 12-Year-Old Children.

Author

Tillaut, Hélène, Monfort, Christine, Giton, Frank, Warembourg, Charline, Rouget, Florence, Cordier, Sylvaine, Lainé, Fabrice, Gaudreau, Eric, Garlantézec, Ronan, Saint-Amour, Dave, and Chevrier, Cécile

Subjects
*PERSISTENT pollutants, *FLUOROALKYL compounds, *THYROID gland, *PERFLUOROOCTANOIC acid, *ORGANOCHLORINE pesticides
Abstract

Introduction: Polychlorobiphenyls (PCBs), organochlorine pesticides (OCPs), and per- and polyfluoroalkyl substances (PFASs) are persistent organic pollutants (POPs) having numerous toxicological properties, including thyroid endocrine disruption. Our aim was to assess the impact of POPs on thyroid hormones among 12-year-old children, while taking puberty into consideration. Methods: Exposure to 7 PCBs, 4 OCPs, and 6 PFASs (in µg/L), and free tri-iodothyronine (fT3, pg/mL), free thyroxine (fT4, ng/dL), and thyroid-stimulating hormones (TSH, mIU/L) were assessed through blood-serum measurements at age 12 years in 249 boys and 227 girls of the PELAGIE mother-child cohort (France). Pubertal status was clinically rated using the Tanner stages. For each POP, associations were estimated using linear regression, adjusted for potential confounders. Results: Among boys, hexachlorobenzene and perfluorodecanoic acid were associated with decreased fT3 (log-scale; β [95% confidence interval] = -0.07 [−0.12,−0.02] and β = −0.03 [−0.06,−0.00], respectively). Intermediate levels of perfluorohexanesulfonic acid (PFHxS) and PCB180 were associated, respectively, with increased and decreased fT4. After stratification on pubertal status, PCBs and OCPs were associated with decreased TSH only in the more advanced Tanner stages (3–5) and with decreased fT3 among early Tanner stages (1–2). Among girls, PFHxS was associated with decreased TSH (log-scale; β = −0.15 [−0.29,-0.00]), and perfluorooctanoic acid was associated with decreased fT3 (β2nd_tercile = −0.06 [−0.10,-0.03] and β3rd_tercile = −0.04 [−0.08,-0.00], versus. 1st tercile). Discussion: This cross-sectional study highlights associations between some POPs and thyroid function disruption, which appears consistent with the literature. Considering that the associations were sex-specific and moderated by pubertal status in boys, complex endocrine interactions are likely involved. [ABSTRACT FROM AUTHOR]

Published
2023
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