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4 results on '"Mongkolspaya J"'

1. Endothelial nitric oxide pathways in the pathophysiology of dengue: a prospective observational study

Author

Yacoub, S, Lam, PK, Huynh, TT, Ho, HH, Thi, HT, Van, NT, Lien, LT, Ha, QNT, Le, DHT, Mongkolspaya, J, Culshaw, A, Yeo, TW, Wertheim, H, Simmons, C, Screaton, G, Wills, B, National Institute for Health Research, Commission of the European Communities, Wellcome Trust, and GlaxoSmithKline Services Unlimited

Subjects
Adult, Male, Adolescent, Arginase, 11 Medical And Health Sciences, 06 Biological Sciences, Arginine, Nitric Oxide, Microbiology, dengue, Young Adult, endothelial function, Humans, Female, l-arginine, Endothelium, Vascular, Prospective Studies, Articles and Commentaries, Biomarkers
Abstract

Endothelial dysfunction/reduced nitric oxide bioavailability is associated with worse plasma leakage in dengue patients and occurs early in the course of the disease. Endothelial dysfunction correlates with lower plasma l-arginine and higher arginase-1 levels., Background Dengue can cause increased vascular permeability that may lead to hypovolemic shock. Endothelial dysfunction may underlie this; however, the association of endothelial nitric oxide (NO) pathways with disease severity is unknown. Methods We performed a prospective observational study in 2 Vietnamese hospitals, assessing patients presenting early (

Published
2017

2. Association of Microvascular Function and Endothelial Biomarkers With Clinical Outcome in Dengue: An Observational Study.

Author

Yacoub, S., Lam, P.K., le, H.M. Vu, Le, T.L., Ha, N.T., Toan, T.T., Van, N.T., Quyen, N.T., Duyen, H.T. Le, Kinh, N. Van, Fox, A., Mongkolspaya, J., Wolbers, M., Simmons, C.P., Screaton, G.R., Wertheim, H.F.L., Wills, B., Yacoub, S., Lam, P.K., le, H.M. Vu, Le, T.L., Ha, N.T., Toan, T.T., Van, N.T., Quyen, N.T., Duyen, H.T. Le, Kinh, N. Van, Fox, A., Mongkolspaya, J., Wolbers, M., Simmons, C.P., Screaton, G.R., Wertheim, H.F.L., and Wills, B.

Abstract

Contains fulltext : 171871.pdf (Publisher’s version ) (Open Access)

Published
2016

3. Association of Microvascular Function and Endothelial Biomarkers With Clinical Outcome in Dengue: An Observational Study

Author

Yacoub, S, Phung, KL, Le, HMV, Thi, LL, Ngo, TH, Tran, TT, Nguyen, TV, Nguyen, THQ, Huynh, TLD, Nguyen, VK, Fox, A, Mongkolspaya, J, Wolbers, M, Simmons, CP, Screaton, GR, Wertheim, H, Wills, B, Yacoub, S, Phung, KL, Le, HMV, Thi, LL, Ngo, TH, Tran, TT, Nguyen, TV, Nguyen, THQ, Huynh, TLD, Nguyen, VK, Fox, A, Mongkolspaya, J, Wolbers, M, Simmons, CP, Screaton, GR, Wertheim, H, and Wills, B

Abstract

BACKGROUND: The hallmark of severe dengue is increased microvascular permeability, but alterations in the microcirculation and their evolution over the course of dengue are unknown. METHODS: We conducted a prospective observational study to evaluate the sublingual microcirculation using side-stream dark-field imaging in patients presenting early (<72 hours after fever onset) and patients hospitalized with warning signs or severe dengue in Vietnam. Clinical findings, microvascular function, global hemodynamics assessed with echocardiography, and serological markers of endothelial activation were determined at 4 time points. RESULTS: A total of 165 patients were enrolled. No difference was found between the microcirculatory parameters comparing dengue with other febrile illnesses. The proportion of perfused vessels (PPV) and the mean flow index (MFI) were lower in patients with dengue with plasma than those without leakage (PPV, 88.1% vs 90.6% [P = .01]; MFI, 2.1 vs 2.4 [P = .007]), most markedly during the critical phase. PPV and MFI were correlated with the endothelial activation markers vascular cell adhesion molecule 1 (P < .001 for both) and angiopoietin 2 (P < .001 for both), negatively correlated. CONCLUSIONS: Modest microcirculatory alterations occur in dengue, are associated with plasma leakage, and are correlate with molecules of endothelial activation, angiopoietin 2 and vascular cell adhesion molecule 1.

Published
2016

4. Association of Microvascular Function and Endothelial Biomarkers With Clinical Outcome in Dengue: An Observational Study.

Author

Yacoub S, Lam PK, Vu le HM, Le TL, Ha NT, Toan TT, Van NT, Quyen NT, Le Duyen HT, Van Kinh N, Fox A, Mongkolspaya J, Wolbers M, Simmons CP, Screaton GR, Wertheim H, and Wills B

Subjects
Adolescent, Adult, Aged, Aged, 80 and over, Blood Vessels diagnostic imaging, Child, Dengue diagnostic imaging, Female, Humans, Male, Middle Aged, Optical Imaging, Prospective Studies, Treatment Outcome, Vietnam, Young Adult, Biomarkers analysis, Blood Vessels pathology, Capillary Permeability, Dengue pathology, Endothelial Cells physiology
Abstract

Background: The hallmark of severe dengue is increased microvascular permeability, but alterations in the microcirculation and their evolution over the course of dengue are unknown., Methods: We conducted a prospective observational study to evaluate the sublingual microcirculation using side-stream dark-field imaging in patients presenting early (<72 hours after fever onset) and patients hospitalized with warning signs or severe dengue in Vietnam. Clinical findings, microvascular function, global hemodynamics assessed with echocardiography, and serological markers of endothelial activation were determined at 4 time points., Results: A total of 165 patients were enrolled. No difference was found between the microcirculatory parameters comparing dengue with other febrile illnesses. The proportion of perfused vessels (PPV) and the mean flow index (MFI) were lower in patients with dengue with plasma than those without leakage (PPV, 88.1% vs 90.6% [P = .01]; MFI, 2.1 vs 2.4 [P = .007]), most markedly during the critical phase. PPV and MFI were correlated with the endothelial activation markers vascular cell adhesion molecule 1 (P < .001 for both) and angiopoietin 2 (P < .001 for both), negatively correlated., Conclusions: Modest microcirculatory alterations occur in dengue, are associated with plasma leakage, and are correlate with molecules of endothelial activation, angiopoietin 2 and vascular cell adhesion molecule 1., (© The Author 2016. Published by Oxford University Press for the Infectious Diseases Society of America.)

Published
2016
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