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Objectives The aim of this study was to investigate the potential of poly(amido amine) (PAMAM) dendrimer decorated graphene oxide (GO) based nanocarrier for targeted delivery of a hydrophobic anticancer drug, quercetin (QSR). Methods GO-PAMAM was successfully synthesized by covalent bonding between GO and NH2-terminated PAMAM dendrimer (zero generation). To investigate drug loading performance, QSR was loaded on the surface of GO as well as GO-PAMAM. Further, the release behaviour of QSR-loaded GO-PAMAM was studied. Finally, an in-vitro sulforhodamine B assay was performed in HEK 293T epithelial cells and MDA MB 231 breast cancer cells. Key findings It was observed that GO-PAMAM shows higher QSR loading capacity compared to GO. Also, synthesized nanocarrier exhibits controlled as well as pH-responsive release of QSR and the amount of QSR released at pH 4 was approximately two times higher than the release at pH 7.4. Furthermore, GO-PAMAM was found to be biocompatible for HEK 293T cells, and a high cytotoxic effect was observed for QSR-loaded GO-PAMAM on MDA MB 231 cells. Conclusions The present investigation highlights the potential application of synthesized hybrid materials as a nanocarrier with excellent loading and controlled releasing efficiency for the delivery of the hydrophobic anticancer drug.

Polymer grafted magnetic graphene oxide (GO–PVP–Fe3O4) as an efficient nanocarrier for the delivery of anticancer drug quercetin.

Murraya koenigii (L.) Spreng, Indian curry leaf plant is widely used in households for imparting a characteristic flavour to Indian dishes. The plant is reported to have significant medicinal value. The essential oil and dried leaves are exported to several countries due to its importance for culinary and medicinal value. Keeping in view, the chemical diversity of the plant, the essential oils from the fresh and shade dried leaves were analysed by GC and GC-MS. Twenty nine compounds were identified in the oil from the fresh material while forty two compounds were present in the dried sample accounting for 93.5 % and 95.7 % of the oil respectively. The main compounds from the fresh sample were trans-caryophyllene (26.7 %), α-pinene (10.7 %), terpinen-4-ol (8.5 %), sabinene (9.9 %), α-humulene (6.6 %) and β-elemene (5.6 %). The shade dried material showed the presence of α-pinene (34.4 %), trans-caryophyllene (11.4 %), sabinene (11.5 %) and terpinen-4-ol (5.3 %). The percentage of α-pinene in shade ...