148 results on '"Montemagni, C."'
Search Results
2. Disorganization and real-world functioning in schizophrenia: Results from the multicenter study of the Italian Network for Research on Psychoses
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Bracale, Nadja, Cardillo, Simona, Brasso, Claudio, Andriola, Ileana, Romano, Raffaella, Caforio, Grazia, Barlati, Stefano, Galluzzo, Alessandro, Deste, Giacomo, Pinna, Federica, Lostia di S. Sofia, Silvia, Lai, Alice, Signorelli, Maria Salvina, Corbo, Mariangela, Baroni, Gaia, Lupi, Matteo, Altamura, Mario, La Montagna, Maddalena, Malerba, Stefania, Murri, Martino Belvederi, Corso, Alessandro, Bugliani, Michele, Pizziconi, Giulia, Rossi, Rodolfo, Serrone, Dario, Giusti, Laura, Ussorio, Donatella, Salza, Anna, Merlotti, Eleonora, Piegari, Giuseppe, Patriarca, Sara, Pietrafesa, Daria, de Bartolomeis, Andrea, Gramaglia, Carla, Gattoni, Eleonora, Marangon, Debora, Grottaroli, Marika, Pigoni, Alessandro, Grassi, Silvia, Cremonese, Carla, Meneguzzo, Paolo, Collantoni, Enrico, Tonna, Matteo, Ossola, Paolo, Gerra, Maria Lidia, Gesi, Camilla, Cremone, IvanMirko, Carpita, Barbara, Brugnoli, Roberto, Comparelli, Anna, Corigliano, Valentina, Di Fabio, Fabio, Buzzanca, Antonio, Girardi, Nicoletta, Niolu, Cinzia, Di Lorenzo, Giorgio, Ribolsi, Michele, Corrivetti, Giulio, Bartoli, Luca, Diasco, Ferdinando, Fagiolini, Andrea, Bolognesi, Simone, Goracci, Arianna, Rocca, P., Galderisi, S., Rossi, A., Bertolino, A., Rucci, P., Gibertoni, D., Montemagni, C., Bellino, S., Aguglia, E., Amore, M., Bellomo, A., Biondi, M., Carpiniello, B., Cuomo, A., D'Ambrosio, E., dell'Osso, L., Girardi, P., Marchesi, C., Monteleone, P., Montemitro, C., Oldani, L., Pacitti, F., Roncone, R., Siracusano, A., Tenconi, E., Vita, A., Zeppegno, P., Steardo, L., Jr, Vignapiano, A., and Maj, M.
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- 2018
- Full Text
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3. Role of 3-monthly long-acting injectable paliperidone in the maintenance of schizophrenia
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Brasso C, Bellino S, Bozzatello P, Montemagni C, and Rocca P
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PP3M ,paliperidone palmitate ,long-acting antipsychotics ,schizophrenia ,efficacy ,safety ,Neurosciences. Biological psychiatry. Neuropsychiatry ,RC321-571 ,Neurology. Diseases of the nervous system ,RC346-429 - Abstract
Claudio Brasso, Silvio Bellino, Paola Bozzatello, Cristiana Montemagni, Paola Rocca Department of Neurosciences “Rita Levi Montalcini”, University of Turin, Turin, Italy Aims: Paliperidone palmitate 3-month (PP3M) represents a new long-acting injectable antipsychotic therapeutic option. This review aims: 1) to summarize available data relating to efficacy, safety, tolerability and costs of PP3M; 2) to describe hospitalization rate, occupational status, treatment preference, satisfaction, adherence and caregiver burden of patients with schizophrenia who participate in PP3M clinical trials; 3) to examine ethical implications, pros and cons of PP3M use and 4) to propose study designs to further assess PP3M.Methods: On August 21, 2017, a search on PubMed about PPM3, without any filter restriction, was conducted and all available records were analyzed. Records written in a language other than English were excluded.Results: Twenty-two records were included in this review: 6 reviews, 1 report, 4 pharmacokinetic studies, 2 cost-effectiveness analyses, 1 open-label clinical trial, 2 randomized controlled trials (RCTs), 5 studies based on these 2 RCTs and 1 observational study.Discussion: According to these last 9 studies, when compared with placebo, PP3M showed a longer time to relapse and good safety and tolerability profiles. Furthermore, when compared with paliperidone palmitate 1 month (PP1M), PP3M treatment showed: 1) non-inferiority in terms of efficacy, safety, tolerability, rate of hospitalization, symptomatic and functional remission, treatment preference and variations of the occupational status; 2) a longer time to relapse after treatment discontinuation and 3) a similar reduction of the caregiver burden.Conclusion: PP3M is the only 3-monthly long-acting injectable antipsychotic available on the market. This makes it a unique option of treatment, which could be chosen both in early and advanced phases of illness. Nonetheless, longer naturalistic follow-up studies, two-arm head-to-head superiority trials and mirror studies, based on real-world samples of patients, are needed to further assess long-term safety and advantages of this new option of treatment and to define patients’ sub-populations that would most beneficiate from it. Keywords: PP3M, paliperidone palmitate, LAI, antipsychotic, clinical assessment, advantages and disadvantages
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- 2017
4. The Meran-Mauls Fault: Tectonic switching from compression to transpression along a restraining bend of the Periadriatic Fault
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Zanchetta, S., primary, Montemagni, C., additional, Mascandola, C., additional, Mair, V., additional, Morelli, C., additional, and Zanchi, A., additional
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- 2023
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5. A cluster-analytical approach toward real-world outcome in outpatients with stable schizophrenia
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Rocca, P., Montemagni, C., Mingrone, C., Crivelli, B., Sigaudo, M., and Bogetto, F.
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- 2016
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6. Second-generation long-acting injectable antipsychotics in schizophrenia: patient functioning and quality of life
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Montemagni C, Frieri T, and Rocca P
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long-acting injectable antipsychotics ,second-generation antipsychotics ,quality of life ,schizophrenia ,functioning ,Neurosciences. Biological psychiatry. Neuropsychiatry ,RC321-571 ,Neurology. Diseases of the nervous system ,RC346-429 - Abstract
Cristiana Montemagni,1,2 Tiziana Frieri,1,2 Paola Rocca1,2 1Department of Neuroscience, Unit of Psychiatry, University of Turin, 2Department of Mental Health, Azienda Sanitaria Locale (ASL) Torino 1 (TO1), Azienda Ospedaliero-Universitaria (AOU) Città della Salute e della Scienza di Torino, Turin, Italy Abstract: Long-acting injectable antipsychotics (LAIs) were developed to make treatment easier, improve adherence, and/or signal the clinician when nonadherence occurs. Second-generation antipsychotic LAIs (SGA-LAIs) combine the advantages of SGA with a long-acting formulation. The purpose of this review is to evaluate the available literature concerning the impact of SGA-LAIs on patient functioning and quality of life (QOL). Although several studies regarding schizophrenia patients’ functioning and QOL have been performed, the quantity of available data still varies greatly depending on the SGA-LAI under investigation. After reviewing the literature, it seems that SGA-LAIs are effective in ameliorating patient functioning and/or QOL of patients with schizophrenia, as compared with placebo. However, while methodological design controversy exists regarding the superiority of risperidone LAI versus oral antipsychotics, the significant amount of evidence in recently published research demonstrates the beneficial influence of risperidone LAI on patient functioning and QOL in stable patients and no benefit over oral treatment in unstable patients. However, the status of the research on SGA-LAIs is lacking in several aspects that may help physicians in choosing the correct drug therapy. Meaningful differences have been observed between SGA-LAIs in the onset of their clinical efficacy and in the relationships between symptoms and functioning scores. Moreover, head-to-head studies comparing the effects of SGA-LAIs on classical measures of psychopathology and functioning are available mainly on risperidone LAI, while those comparing olanzapine LAI with other SGA-LAIs are still lacking. Lastly, some data on their use, especially in first-episode or recent-onset schizophrenia and in refractory or treatment-resistant schizophrenia, is available. Keywords: outcome, first-episode schizophrenia, recent-onset schizophrenia, treatment resistant schizophrenia
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- 2016
7. A review of localization of the deformation in Garhwal Himalaya: younging activation of shear zones from the metamorphic core of the belt towards the foreland
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Carosi R., Montomoli C., Iaccarino S., Montemagni C., Benetti B., Carosi, R, Montomoli, C, Iaccarino, S, Montemagni, C, and Benetti, B
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Structural analyse ,Garhwal ,Shear zone ,Geochronology ,Exhumation - Abstract
Recent studies highlighted that, starting from ~23 Ma onwards, deformation in Garhwal Himalaya (NW India) localized first in the inner part of the Greater Himalayan Sequence (GHS) along the Badrinath shear zone (BSZ) and subsequently along the Main Central thrust zone (MCTz), made by the upper Vaikrita thrust (VT) and the lower Munsiari 40 39 thrust (MT). Detailed in-situ geochronology by U-Th-Pb on monazite and Ar / Ar on micas demonstrated that these thrust-sense shear zones were active in different times from the older BSZ active at 23-21 Ma, through the VT 20-16 to 9-8 Ma up to the younger MT, active at 5-4 Ma. The consequences are twofold: a) all deformation in the MCTz was not active at the same time but in at different times, as deformation migrated from the upper levels to the lower levels of the GHS in few Myrs. In addition, the static growth of micas after deformation testifies that once deformation migrated to the lower shear zone levels, the levels, the deformation in the upper part ceased; b) the downward sequence of deformation demonstrates that the GHS and Lesser Himalayan Sequence were exhumed by an “in-sequence shearing” deformation resulting in the earlier exhumation of the upper portions of the metamorphic core.
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- 2022
8. Prolonged extension in the middle and upper continental crust: insights into the Simplon Shear Zone (Western Alps)
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Montemagni, C, Zanchetta, S, Carmina, B, Fascio, L, Innamorati, G, Pasero, M, Petti, FM, Montemagni, C, and Zanchetta, S
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GEO/03 - GEOLOGIA STRUTTURALE ,Simplon Shear Zone, kinematic vorticity, Ar/Ar geochronology - Published
- 2022
9. Genome-wide association study detected novel susceptibility genes for social cognition impairment in people with schizophrenia
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Gennarelli, M., Monteleone, P., Minelli, A., Monteleone, A. M., Rossi, A., Rocca, P., Bertolino, A., Aguglia, E., Amore, M., Bellino, S., Bellomo, A., Biondi, M., Bucci, P., Carpiniello, B., Cascino, G., Cuomo, A., Dell'Osso, L., di Giannantonio, M., Giordano, G. M., Marchesi, C., Oldani, L., Pompili, M., Roncone, R., Rossi, R., Siracusano, A., Tenconi, E., Vita, A., Zeppegno, P., Galderisi, S., Maj, M., Corrivetti, G., Del Buono, G., Torretta, S., Calia, V., Raio, A., Barlati, S., Deste, G., Magri, C., Valsecchi, P., Pinna, F., Muscas, M., Marras, L., Piegari, G., Giuliani, L., Brando, F., Coccia, C., Concerto, C., Poli, L. F., Surace, T., Martinotti, G., Pettorruso, M., Fraticelli, S., Altamura, M., Pasquale Tortorelli, F. M., Mollica, A., Calcagno, P., Murri, M. B., Serafini, G., Pacitti, F., Socci, V., Lucaselli, A., Giusti, L., Mammarella, S., Bianchini, V., Gramaglia, C., Gambaro, E., Martelli, M., Favaro, A., Meneguzzo, P., Collantoni, E., Tonna, M., Ossola, P., Gerra, M. L., Carmassi, C., Carpita, B., Cremone, I. M., Comparelli, A., Brugnoli, R., Corigliano, V., Fagiolini, A., Bolognesi, S., Goracci, A., Di Lorenzo, G., Ribolsi, M., Niolu, C., Bozzatello, P., Brasso, C., Montemagni, C., Buzzanca, A., Di Fabio, F., Girardi, N., Gennarelli, Massimo, Monteleone, Palmiero, Minelli, Alessandra, Monteleone, Alessio Maria, Rossi, Alessandro, Rocca, Paola, Bertolino, Alessandro, Aguglia, Eugenio, Amore, Mario, Bellino, Silvio, Bellomo, Antonello, Biondi, Massimo, Bucci, Paola, Carpiniello, Bernardo, Cascino, Giammarco, Cuomo, Alessandro, Dell'Osso, Liliana, di Giannantonio, Massimo, Giordano, Giulia Maria, Marchesi, Carlo, Oldani, Lucio, Pompili, Maurizio, Roncone, Rita, Rossi, Rodolfo, Siracusano, Alberto, Tenconi, Elena, Vita, Antonio, Zeppegno, Patrizia, Galderisi, Silvana, and Maj, Mario
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Treatment outcome ,GWAS ,Social cognition ,TMEM74 ,meta-analysis ,schizophrenia ,Genetic Predisposition to Disease ,Genome-Wide Association Study ,Humans ,Membrane Proteins ,Polymorphism, Single Nucleotide ,Schizophrenia ,Social Cognition ,Susceptibility gene ,Genome-wide association study ,Biology ,Affect (psychology) ,meta-analysi ,03 medical and health sciences ,0302 clinical medicine ,medicine ,SNP ,Polymorphism ,Biological Psychiatry ,Genetics ,Single Nucleotide ,medicine.disease ,030227 psychiatry ,Psychiatry and Mental health ,Settore MED/25 ,Meta-analysis - Abstract
Objectives People with schizophrenia (SCZ) present serious and generalised deficits in social cognition (SC), which affect negatively patients' functioning and treatment outcomes. The genetic background of SC has been investigated in disorders other than SCZ providing weak and sparse results. Thus, our aim was to explore possible genetic correlates of SC dysfunctions in SCZ patients with a genome-wide study (GWAS) approach. Methods We performed a GWAS meta-analysis of data coming from two cohorts made of 242 and 160 SCZ patients, respectively. SC was assessed with different tools in order to cover its different domains. Results We found GWAS significant association between the TMEM74 gene and the patients' ability in social inference as assessed by The Awareness of Social Inference Test; this association was confirmed by both SNP-based analysis (lead SNP rs3019332 p-value = 5.24 × 10-9) and gene-based analysis (p-value = 1.09 × 10-7). Moreover, suggestive associations of other genes with different dimensions of SC were also found. Conclusions Our study shows for the first time GWAS significant or suggestive associations of some gene variants with SC domains in people with SCZ. These findings should stimulate further studies to characterise the genetic underpinning of SC dysfunctions in SCZ.
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- 2022
10. Joint structural-functional magnetic resonance imaging features are associated with diagnosis and real-world functioning in patients with schizophrenia
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Antonucci, L. A., Fazio, L., Pergola, G., Blasi, G., Stolfa, G., Di Palo, P., Mucci, A., Rocca, P., Brasso, C., di Giannantonio, M., Maria Giordano, G., Monteleone, P., Pompili, M., Siracusano, A., Bertolino, A., Galderisi, S., Maj, M., Muzzarelli, L., Nettis, M. A., Nicoli, M., Papalino, M., Passiatore, R., Romano, R., Piegari, G., Pezzella, P., Perrottelli, A., Martinotti, G., Pettorruso, M., Fraticelli, S., Comparelli, A., Corigliano, V., Brugnoli, R., Di Lorenzo, G., Niolu, C., Ribolsi, M., Cascino, G., Esposito, F., Russo, A. G., Montemagni, C., Riccardi, C., Del Favero, E., Antonucci, L. A., Fazio, L., Pergola, G., Blasi, G., Stolfa, G., Di Palo, P., Mucci, A., Rocca, P., Brasso, C., di Giannantonio, M., Giordano, Giulia M., Monteleone, P., Pompili, M., Siracusano, A., Bertolino, A., Galderisi, S., and Maj, M.
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Cerebral Cortex ,Real-world functioning ,Rest ,jICA ,Brain ,Magnetic Resonance Imaging ,Psychiatry and Mental health ,Structural MRI ,Settore MED/25 ,Degree centrality ,Resting-state fMRI ,Schizophrenia ,Humans ,Gray Matter ,Biological Psychiatry - Abstract
Objective: Earlier evidence suggested that structural–functional covariation in schizophrenia patients (SCZ) is associated with cognition, a predictor of functioning. Moreover, studies suggested that functional brain abnormalities of schizophrenia may be related with structural network features. However, only few studies have investigated the relationship between structural–functional covariation and both diagnosis and functioning in SCZ. We hypothesized that structural–functional covariation networks associated with diagnosis are related to real-world functioning in SCZ. Methods: We performed joint Independent Component Analysis on T1 images and resting-state fMRI-based Degree Centrality (DC) maps from 89 SCZ and 285 controls. Structural-functional covariation networks in which we found a main effect of diagnosis underwent correlation analysis to investigate their relationship with functioning. Covariation networks showing a significant association with both diagnosis and functioning underwent univariate analysis to better characterize group-level differences at the spatial level. Results: A structural–functional covariation network characterized by frontal, temporal, parietal and thalamic structural estimates significantly covaried with temporo-parietal resting-state DC. Compared with controls, SCZ had reduced structural–functional covariation within this network (pFDR = 0.005). The same measure correlated positively with both social and occupational functioning (both pFDR = 0.042). Univariate analyses revealed grey matter deviations in SCZ compared with controls within this structural–functional network in hippocampus, cerebellum, thalamus, orbito-frontal cortex, and insula. No group differences were found in DC. Conclusions: Findings support the existence of a phenotypical association between group-level differences and inter-individual heterogeneity of functional deficits in SCZ. Given that only the joint structural/functional analysis revealed this association, structural–functional covariation may be a potentially relevant schizophrenia phenotype.
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- 2022
11. A review of localization of the deformation in Garhwal Himalaya: younging activation of shear zones from the metamorphic core of the belt towards the foreland
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Carosi, R., Montomoli, C., Iaccarino, S., Montemagni, C., and YURI BENETTI SILVA, B.
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Garhwal ,Shear zone ,structural analyses ,geochronology ,exhumation ,Shear zone, exhumation, structural analyses, geochronology, Garhwal - Published
- 2022
12. Prevalence of antipsychotic-induced extrapyramidal symptoms and their association with neurocognition and social cognition in outpatients with schizophrenia in the 'real-life'
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Monteleone, P., Cascino, G., Monteleone, A. M., Rocca, P., Rossi, A., Bertolino, A., Aguglia, E., Amore, M., Collantoni, E., Corrivetti, G., Cuomo, A., Bellomo, A., D'Ambrosio, E., Dell'Osso, L., Frascarelli, M., Giordano, G. M., Giuliani, L., Marchesi, C., Montemagni, C., Oldani, L., Pinna, F., Pompili, M., Roncone, R., Rossi, R., Siracusano, A., Vita, A., Zeppegno, P., Galderisi, S., Maj, M., Del Buono, G., Marciello, F., Di Palo, P., Sangiuliano, M., Di Gioia, C., Barlati, S., Deste, G., Turrina, C., Carpiniello, B., Marras, L., Muscas, M., Bucci, P., Piegari, G., Brando, F., Aiello, C., Poli, L. F., Saitta, G., Surace, T., Altamura, M., Malerba, S., Padalino, F., Calcagno, P., Murri, M. B., Escelsior, A., Giusti, L., Bianchini, V., Salza, A., Pacitti, F., Socci, V., Lucaselli, A., De Bartolomeis, A., Gramaglia, C., Feggi, A., Jona, A., Favaro, A., Tenconi, E., Meneguzzo, P., Ossola, P., Tonna, M., Gerra, M. L., Carmassi, C., Cremone, I. M., Carpita, B., Biondi, M., Di Fabio, F., Accinni, T., Brugnoli, R., Comparelli, A., Corigliano, V., Fagiolini, A., Bolognesi, S., Goracci, A., Di Lorenzo, G., Ribolsi, M., Niolu, C., Brasso, C., Riccardi, C., Del Favero, E., Monteleone, P., Cascino, G., Monteleone, A. M., Rocca, P., Rossi, A., Bertolino, A., Aguglia, E., Amore, M., Collantoni, E., Corrivetti, G., Cuomo, A., Bellomo, A., D'Ambrosio, E., Dell'Osso, L., Frascarelli, M., Giordano, G. M., Giuliani, L., Marchesi, C., Montemagni, C., Oldani, L., Pinna, F., Pompili, M., Roncone, R., Rossi, R., Siracusano, A., Vita, A., Zeppegno, P., Galderisi, S., and Maj, M.
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Adult ,Male ,Social Cognition ,Extrapyramidal symptoms ,Chlorpromazine ,medicine.medical_treatment ,Antipsychotic ,03 medical and health sciences ,0302 clinical medicine ,Cognition ,Basal Ganglia Diseases ,Social cognition ,Prevalence ,Medicine ,Antipsychotics ,Humans ,Extrapyramidal symptom ,Neurocognition ,Biological Psychiatry ,Pharmacology ,business.industry ,Parkinsonism ,Middle Aged ,medicine.disease ,Risperidone ,030227 psychiatry ,Settore MED/25 ,Schizophrenia ,Female ,Schizophrenic Psychology ,medicine.symptom ,business ,Neurocognitive ,Antipsychotic Agents ,Psychopathology ,Clinical psychology - Abstract
First generation antipsychotics (FGAs) are more likely to induce extrapyramidal side-effects (EPS) than second generation antipsychotics (SGAs), and EPS have been shown associated to cognitive deficits in schizophrenia. So far, no study has explored the relationships between EPS and social cognition (SC) in people with schizophrenia. Therefore, we assessed the prevalence of EPS in a large sample of drug-treated community-dwelling persons with schizophrenia and explored their relationships with patients' neurocognitive and SC abilities. 875 patients underwent EPS, psychopathological, neurocognitive and SC assessments by means of standardized measures. Relationships between EPS, psychopathology and neurocognitive and SC measures were investigated by correlation tests. Moreover, a partial correlation network was computed by means of a network analysis. 256 patients were treated with FGAs alone or in combination with SGA and 619 with SGAs. EPS were significantly more frequent in FGA-treated group than in the SGA-treated one. Patients with EPS disclosed a more severe psychopathology and were more impaired in neurocognitive and SC measures compared to those without EPS. Disorganization, expressive deficit, and duration of illness were significantly associated to both neurocognitive and SC measures while EPS were associated to neurocognitive measures only. The network analysis showed that parkinsonism was the sole EPS directly connected to both psychopathological and neurocognitive indices whereas no direct connection emerged between EPS and SC measures. Present findings confirm that EPS are still present in the era of SGAs and contribute, together with other clinical variables, to the neurocognitive but not to the SC impairment of patients with schizophrenia.
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- 2021
13. The influence of autistic symptoms on social and non-social cognition and on real-life functioning in people with schizophrenia: Evidence from the Italian Network for Research on Psychoses multicenter study
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Vita, A., Barlati, S., Deste, G., Rocca, P., Rossi, A., Bertolino, A., Aguglia, E., Amore, M., Bellomo, A., Biondi, M., Carpiniello, B., Collantoni, E., Cuomo, A., D'Ambrosio, E., dell' Osso, L., di Giannantonio, M., Giordano, G. M., Marchesi, C., Monteleone, P., Montemagni, C., Oldani, L., Pompili, M., Roncone, R., Rossi, R., Siracusano, A., Zeppegno, P., Nibbio, G., Galderisi, S., Maj, M., Ceraso, A., Galluzzo, A., Lisoni, J., Di Palo, P., Papalino, M., Romano, R., Pinna, F., Lai, A., di Santa Sofia, S. L., Bucci, P., Piegari, G., Brando, F., Giuliani, L., Signorelli, M. S., Poli, L. F., Martinotti, G., Pettorruso, M., Montemitro, C., Altamura, M., Malerba, S., Padalino, F., Amerio, A., Cal-Cagno, P., Zampogna, D., Giusti, L., Salza, A., Mammarella, S., Pacitti, F., Socci, V., Talevi, D., Gramaglia, C., Feggi, A., Jona, A., Favaro, A., Tenconi, E., Meneguzzo, P., Ossola, P., Tonna, M., Gerra, M. L., Carmassi, C., Gesi, C., Carpita, B., Corrivetti, G., Cascino, G., del Buono, G., Di Fabio, F., Buzzanca, A., Girardi, N., Brugnoli, R., Comparelli, A., Corigliano, V., Fagiolini, A., Bolognesi, S., Goracci, A., Di Lorenzo, G., Niolu, C., Ribolsi, M., Brasso, C., Riccardi, C., Del Favero, E., Vita, A., Barlati, S., Deste, G., Rocca, P., Rossi, A., Bertolino, A., Aguglia, E., Amore, M., Bellomo, A., Biondi, M., Carpiniello, B., Collantoni, E., Cuomo, A., D'Ambrosio, E., dell' Osso, L., di Giannantonio, M., Giordano, G. M., Marchesi, C., Monteleone, P., Montemagni, C., Oldani, L., Pompili, M., Roncone, R., Rossi, R., Siracusano, A., Zeppegno, P., Nibbio, G., Galderisi, S., Maj, M., Ceraso, A., Galluzzo, A., Lisoni, J., Di Palo, P., Papalino, M., Romano, R., Pinna, F., Lai, A., di Santa Sofia, S. L., Bucci, P., Piegari, G., Brando, F., Giuliani, L., Signorelli, M. S., Poli, L. F., Martinotti, G., Pettorruso, M., Montemitro, C., Altamura, M., Malerba, S., Padalino, F., Amerio, A., Cal-Cagno, P., Zampogna, D., Giusti, L., Salza, A., Mammarella, S., Pacitti, F., Socci, V., Talevi, D., Gramaglia, C., Feggi, A., Jona, A., Favaro, A., Tenconi, E., Meneguzzo, P., Ossola, P., Tonna, M., Gerra, M. L., Carmassi, C., Gesi, C., Carpita, B., Corrivetti, G., Cascino, G., del Buono, G., Di Fabio, F., Buzzanca, A., Girardi, N., Brugnoli, R., Comparelli, A., Corigliano, V., Fagiolini, A., Bolognesi, S., Goracci, A., Di Lorenzo, G., Niolu, C., Ribolsi, M., Brasso, C., Riccardi, C., and Del Favero, E.
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schizophrenia ,autism spectrum disorders ,cognition ,psychosocial functioning ,social cognition ,Adult ,Male ,Social Cognition ,Interpersonal Relation ,autism spectrum disorders, cognition, psychosocial functioning, schizophrenia, social cognition ,Disease ,Autism spectrum disorders ,Cognition ,Psychosocial functioning ,Schizophrenia ,Social cognition ,Psychotic Disorder ,behavioral disciplines and activities ,03 medical and health sciences ,Interpersonal relationship ,0302 clinical medicine ,mental disorders ,Medicine ,Humans ,Interpersonal Relations ,Autism spectrum disorder ,Autistic Disorder ,business.industry ,medicine.disease ,030227 psychiatry ,Psychiatry and Mental health ,Multicenter study ,Settore MED/25 ,Italy ,Psychotic Disorders ,Autism ,Female ,Verbal memory ,business ,030217 neurology & neurosurgery ,Research Article ,Clinical psychology ,Human - Abstract
Background Autism spectrum disorders (ASDs) and schizophrenia spectrum disorders (SSDs), although conceptualized as separate entities, may share some clinical and neurobiological features. ASD symptoms may have a relevant role in determining a more severe clinical presentation of schizophrenic disorder but their relationships with cognitive aspects and functional outcomes of the disease remain to be addressed in large samples of individuals. Aims To investigate the clinical, cognitive, and functional correlates of ASD symptoms in a large sample of people diagnosed with schizophrenia. Methods The severity of ASD symptoms was measured with the PANSS Autism Severity Scale (PAUSS) in 921 individuals recruited for the Italian Network for Research on Psychoses multicenter study. Based on the PAUSS scores, three groups of subjects were compared on a wide array of cognitive and functional measures. Results Subjects with more severe ASD symptoms showed a poorer performance in the processing speed (p = 0.010), attention (p = 0.011), verbal memory (p = 0.035), and social cognition (p = 0.001) domains, and an overall lower global cognitive composite score (p = 0.010). Subjects with more severe ASD symptoms also showed poorer functional capacity (p = 0.004), real-world interpersonal relationships (p p Conclusions These findings strengthen the notion that ASD symptoms may have a relevant impact on different aspects of the disease, crucial to the life of people with schizophrenia. Prominent ASD symptoms may characterize a specific subpopulation of individuals with SSD.
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- 2020
14. The Main Central Thrust zone along the Alaknanda and Dhauli Ganga valleys (Garhwal Himalaya, NW India): Insights into an inverted metamorphic sequence
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Iaccarino S.[1], Montomoli C.[1, Montemagni C.[3], Massonne H.-J.[4, Langone A.[6], Jain A.K.[7], Visonà D.[8], Carosi R.[1], Iaccarino, S, Montomoli, C, Montemagni, C, Massonne, H, Langone, A, Jain, A, Visona, D, and Carosi, R
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010504 meteorology & atmospheric sciences ,Metamorphic rock ,Himalayan tectonics and metamorphisms ,Geochemistry ,Metamorphism ,Himalayan tectonics and metamorphism ,010502 geochemistry & geophysics ,01 natural sciences ,Kyanite ,Geochemistry and Petrology ,Main Central Thrust ,0105 earth and related environmental sciences ,Inverted metamorphisms ,Main Central Thrust zone ,P-T-D-t paths ,Inverted metamorphism ,main Central Thrust zone ,inverted metamorphisms ,Geology ,visual_art ,Staurolite ,visual_art.visual_art_medium ,Shear zone ,Protolith ,Mylonite - Abstract
New tectono-metamorphic data along the Alaknanda-Dhauli Ganga valleys in the Garhwal Himalaya (NW India) are presented focusing on sheared rocks of the Main Central Thrust zone (MCTz), one of the first order regional structures in the Himalaya. In regard of large hot orogens (LHOs), the MCTz corresponds to the base of the low-viscosity infrastructure. Our new findings support that the MCTz is a c. 4 km thick mylonitic zone, affecting different lithologies and encompassing a possible (previously defined) protolith boundary. Four selected mylonitic samples, at different structural position along the MCTz, were studied with a multi-disciplinary approach in detail, supporting that an inverted metamorphic field gradient, with temperature (T) and pressure (P) ranging from c. 500 up to c. 700 °C and c. 0.50–0.60 GPa up to >1.0 GPa, was present. This inverted P-T array is also discernable by the distribution of Al-rich minerals (e.g. chloritoid, staurolite, kyanite) in the intercalation of sheared quartzite. In situ U-(Th)-Pb monazite geochronology indicates that the high-T shearing in the upper part of the MCTz mylonites developed from c. 20 Ma on after a stage of prograde metamorphism that lasted until c. 23 Ma. The integration of our data with available structural, metamorphic and geochronological information along the MCTz profile, in the study area, sheds light on the development of the associated inverted metamorphic sequence (IMS). These data carry also empirical finite patterns to be tested against theoretical models investigating the possible roles of viscous heating and “tectonic overpressure” in the development of the IMS in the Himalaya, and possibly in LHOs in general. Both phenomena, if have been active at all, are not obvious in regard of the current state of geothermobarometric methods. On the contrary, a model for the tectonic assembly of the IMS is favored. The anomalous apparent P and T inverted field gradients are interpreted to be the result of the differential and diachronous transport along a shear zone experiencing heterogeneous vertical thinning linked to the non-coaxial flow.
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- 2020
15. The association between insight and depressive symptoms in schizophrenia: Undirected and Bayesian network analyses
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Amore, M., Murri, M. B., Calcagno, P., Rocca, P., Rossi, A., Aguglia, E., Bellomo, A., Blasi, G., Carpiniello, B., Cuomo, A., Dell'Osso, L., Di Giannantonio, M., Giordano, G. M., Marchesi, C., Monteleone, P., Montemagni, C., Oldani, L., Pompili, M., Roncone, R., Rossi, R., Siracusano, A., Vita, A., Zeppegno, P., Corso, A., Arzani, C., Galderisi, S., Maj, M., Petrilli, G., Respino, M., Papalino, M., Falsetti, A., Calia, V. M., Barlati, S., Deste, G., Turrina, C., Pinna, F., Lai, A., Di Santa Sofia, S. L., Signorelli, M. S., Petralia, A., Pettorruso, M., Barone, G., Salone, A., Piegari, G., Aiello, C., Brando, F., Giuliani, L., Altamura, M., Carnevale, R., Padalino, F., Giusti, L., Salza, A., Ussorio, D., Pizziconi, G., Santarelli, V., Pacitti, F., De Bartolomeis, A., Gambaro, E., Gattoni, E., Gramaglia, C., De Panfilis, C., Ossola, P., Tonna, M., Carmassi, C., Carpita, B., Cremone, I., Comparelli, A., Corigliano, V., Brugnoli, R., Corrivetti, G., Cascino, G., Del Buono, G., Fagiolini, A., Bolognesi, S., Goracci, A., Di Lorenzo, G., Niolu, C., Ribolsi, M., Bellino, S., Bozzatello, P., Brasso, C., Amore, M., Murri, M. B., Calcagno, P., Rocca, P., Rossi, A., Aguglia, E., Bellomo, A., Blasi, G., Carpiniello, B., Cuomo, A., Dell'Osso, L., di Giannantonio, M., Giordano, G. M., Marchesi, C., Monteleone, P., Montemagni, C., Oldani, L., Pompili, M., Roncone, R., Rossi, R., Siracusano, A., Vita, A., Zeppegno, P., Corso, A., Arzani, C., Galderisi, S., and Maj, M.
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Adult ,Male ,media_common.quotation_subject ,Social Stigma ,Hostility ,NO ,Suicidal Ideation ,Extrapyramidal symptoms ,Demoralization ,depression ,insight ,sadness ,schizophrenia ,self-esteem ,Sadness ,Self-esteem ,medicine ,Humans ,Suicidal ideation ,media_common ,Depression ,Insight ,Schizophrenia ,Bayes Theorem ,Cross-Sectional Studies ,Diagnostic and Statistical Manual of Mental Disorders ,Female ,Middle Aged ,Self Concept ,Social Class ,Guilt ,Schizophrenic Psychology ,Positive and Negative Syndrome Scale ,Sadne ,medicine.disease ,Psychiatry and Mental health ,Settore MED/25 ,medicine.symptom ,Psychology ,Neurocognitive ,Research Article ,Clinical psychology ,Diagnosis of schizophrenia - Abstract
Background. Greater levels of insight may be linked with depressive symptoms among patients with schizophrenia, however, it would be useful to characterize this association at symptom-level, in order to inform research on interventions. Methods. Data on depressive symptoms (Calgary Depression Scale for Schizophrenia) and insight (G12 item from the Positive and Negative Syndrome Scale) were obtained from 921 community-dwelling, clinically-stable individuals with a DSM-IV diagnosis of schizophrenia, recruited in a nationwide multicenter study. Network analysis was used to explore the most relevant connections between insight and depressive symptoms, including potential confounders in the model (neurocognitive and social-cognitive functioning, positive, negative and disorganization symptoms, extrapyramidal symptoms, hostility, internalized stigma, and perceived discrimination). Bayesian network analysis was used to estimate a directed acyclic graph (DAG) while investigating the most likely direction of the putative causal association between insight and depression. Results. After adjusting for confounders, better levels of insight were associated with greater self-depreciation, pathological guilt, morning depression and suicidal ideation. No difference in global network structure was detected for socioeconomic status, service engagement or illness severity. The DAG confirmed the presence of an association between greater insight and self-depreciation, suggesting the more probable causal direction was from insight to depressive symptoms. Conclusions. In schizophrenia, better levels of insight may cause self-depreciation and, possibly, other depressive symptoms. Person-centered and narrative psychotherapeutic approaches may be particularly fit to improve patient insight without dampening self-esteem., Highlights Better insight seems associated with depressive symptoms in schizophrenia.Network analyses were used to explore this association in a large sample.Insight was associated with self-depreciation, guilt, and suicidal ideation.Although cross-sectional, data suggest causal direction from insight to depression.
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- 2020
16. Factors Associated With Real-Life Functioning in Persons With Schizophrenia in a 4-Year Follow-up Study of the Italian Network for Research on Psychoses
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Mucci, A., Galderisi, S., Gibertoni, D., Rossi, A., Rocca, P., Bertolino, A., Aguglia, E., Amore, M., Bellomo, A., Biondi, M., Blasi, G., Brasso, C., Bucci, P., Carpiniello, B., Cuomo, A., Dell'Osso, L., Giordano, G. M., Marchesi, C., Monteleone, P., Niolu, C., Oldani, L., Pettorruso, M., Pompili, M., Roncone, R., Rossi, R., Tenconi, E., Vita, A., Zeppegno, P., Maj, M., Piegari, G., Aiello, C., Brando, F., Giuliani, L., Palumbo, D., Coccia, C., Papalino, M., Calia, V., Romano, R., Barlati, S., Deste, G., Valsecchi, P., Pinna, F., Lai, A., Lostia di Santa Sofia, S., Salvina Signorelli, M., Fusar Poli, L., Surace, T., Martinotti, G., Montemitro, C., Fraticelli, S., Altamura, M., Angelini, E., Elia, A., Calcagno, P., Belvederi Murri, M., Cattedra, S., Pacitti, F., Talevi, D., Socci, V., Giusti, L., Salza, A., Mammarella, S., de Bartolomeis, A., Favaro, A., Collantoni, E., Meneguzzo, P., Tonna, M., Ossola, P., Gerra, M. L., Gramaglia, C., Binda, V., Gambaro, E., Carmassi, C., Carpita, B., Cremone, I. M., Corrivetti, G., Cascino, G., Del Buono, G., Brugnoli, R., Comparelli, A., Corigliano, V., Buzzanca, A., Gerardi, N., Frascarelli, M., Fagiolini, A., Goracci, A., Bolognesi, S., Siracusano, A., Di Lorenzo, G., Ribolsi, M., Montemagni, C., Riccardi, C., Del Favero, E., Mucci, A., Galderisi, S., Gibertoni, D., Rossi, A., Rocca, P., Bertolino, A., Aguglia, E., Amore, M., Bellomo, A., Biondi, M., Blasi, G., Brasso, C., Bucci, P., Carpiniello, B., Cuomo, A., Dell'Osso, L., Giordano, G. M., Marchesi, C., Monteleone, P., Niolu, C., Oldani, L., Pettorruso, M., Pompili, M., Roncone, R., Rossi, R., Tenconi, E., Vita, A., Zeppegno, P., Maj, M., Mucci A., Galderisi S., Gibertoni D., Rossi A., Rocca P., Bertolino A., Aguglia E., Amore M., Bellomo A., Biondi M., Blasi G., Brasso C., Bucci P., Carpiniello B., Cuomo A., Dell'Osso L., Giordano G.M., Marchesi C., Monteleone P., Niolu C., Oldani L., Pettorruso M., Pompili M., Roncone R., Rossi R., Tenconi E., Vita A., Zeppegno P., and Maj M.
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Adult ,Hospitals, Psychiatric ,Male ,Mental Health Services ,Social Cognition ,Apathy ,Psychological intervention ,Relapse prevention ,schizophrenia ,functioning ,psychopatology ,Structural equation modeling ,03 medical and health sciences ,0302 clinical medicine ,Medicine ,Humans ,Cognitive Dysfunction ,Female ,Follow-Up Studies ,Independent Living ,Italy ,Middle Aged ,Psychotic Disorders ,Schizophrenia ,Functional Status ,Original Investigation ,business.industry ,Mental health ,Hospitals ,Cognitive training ,030227 psychiatry ,Psychiatry and Mental health ,Settore MED/25 ,schizophrenia, real-life functioning, SEM ,Psychiatric ,Work Skills ,business ,Psychosocial ,030217 neurology & neurosurgery ,Psychopathology ,Clinical psychology - Abstract
Importance: The goal of schizophrenia treatment has shifted from symptom reduction and relapse prevention to functional recovery; however, recovery rates remain low. Prospective identification of variables associated with real-life functioning domains is essential for personalized and integrated treatment programs. Objective: To assess whether baseline illness-related variables, personal resources, and context-related factors are associated with work skills, interpersonal relationships, and everyday life skills at 4-year follow-up. Design, Setting, and Participants: This multicenter prospective cohort study was conducted across 24 Italian university psychiatric clinics or mental health departments in which 921 patients enrolled in a cross-sectional study were contacted after 4 years for reassessment. Recruitment of community-dwelling, clinically stable persons with schizophrenia was conducted from March 2016 to December 2017, and data were analyzed from January to May 2020. Main Outcomes and Measures: Psychopathology, social and nonsocial cognition, functional capacity, personal resources, and context-related factors were assessed, with real-life functioning as the main outcome. Structural equation modeling, multiple regression analyses, and latent change score modeling were used to identify variables that were associated with real-life functioning domains at follow-up and with changes from baseline in these domains. Results: In total, 618 participants (427 male [69.1%]; mean [SD] age, 45.1 [10.5] years) were included. Five baseline variables were directly associated with real-life functioning at follow-up: neurocognition with everyday life (β, 0.274; 95% CI, 0.207-0.341; P
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- 2021
17. Clinical outcome and length of stay in an Italian Psychiatric Emergency Service
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Frieri, T., Montemagni, C., Rocca, G., Rocca, P., and Villari, V.
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- 2013
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18. Outcome and length of stay in psychiatric hospitalization, the experience of the University Clinic of Turin
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Rocca, Paola, Mingrone, C., Mongini, T., Montemagni, C., Pulvirenti, L., Rocca, G., and Bogetto, F.
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- 2010
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19. Premorbid academic and social functioning in patients with schizophrenia and its associations with negative symptoms and cognition
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Bucci, P., Galderisi, S., Mucci, A., Rossi, A., Rocca, P., Bertolino, A., Aguglia, E., Amore, M., Andriola, I., Bellomo, A., Biondi, M., Cuomo, A., Dell'Osso, L., Favaro, A., Gambi, F., Giordano, G. M., Girardi, P., Marchesi, C., Monteleone, P., Montemagni, C., Niolu, C., Oldani, L., Pacitti, F., Pinna, F., Roncone, R., Vita, A., Zeppegno, P., Maj, M., Patriarca, Sara, Pietrafesa, Daria, Aiello, Carmen, Longo, Luisa, Barone, Marina, Romano, Raffaella, Atti, Anna Rita, Barlati, Stefano, Deste, Giacomo, Valsecchi, Paolo, Carpiniello, Bernardo, Tusconi, Massimo, Puddu, Laura, Signorelli, Maria Salvina, Cannavò, Dario, Minutolo, Giuseppe, Corbo, Mariangela, Montemitro, Chiara, Baroni, Gaia, Altamura, Mario, La Montagna, Maddalena, Carnevale, Raffaella, Murri, Martino Belvederi, Calcagno, Pietro, Bugliani, Michele, Pizziconi, Giulia, Logozzo, Francesca, Rossi, Rodolfo, Giusti, Laura, Salza, Anna, Malavolta, Maurizio, Orsenigo, Giulia, Grassi, Silvia, De Bartolomeis, Andrea, Gramaglia, Carla, Gattoni, Eleonora, Gambaro, Eleonora, Tenconi, Elena, Ferronato, Luisa, Collantoni, Enrico, Tonna, Matteo, Ossola, Paolo, Gerra, Maria Lidia, Carmassi, Claudia, Cremone, Ivan Mirko, Carpita, Barbara, Buzzanca, Antonio, Girardi, Nicoletta, Frascarelli, Marianna, Del Casale, Antonio, Comparelli, Anna, Corigliano, Valentina, Siracusano, Alberto, Di Lorenzo, Giorgio, Ribolsi, Michele, Corrivetti, Giulio, Bartoli, Luca, Del Buono, Gianfranco, Fagiolini, Andrea, Bolognesi, Simone, Goracci, Arianna, Mancini, Irene, Bava, Irene, Cardillo, Simona, Bucci P., Galderisi S., Mucci A., Rossi A., Rocca P., Bertolino A., Aguglia E., Amore M., Andriola I., Bellomo A., Biondi M., Cuomo A., dell'Osso L., Favaro A., Gambi F., Giordano G.M., Girardi P., Marchesi C., Monteleone P., Montemagni C., Niolu C., Oldani L., Pacitti F., Pinna F., Roncone R., Vita A., Zeppegno P., Maj M., Patriarca S., Pietrafesa D., Aiello C., Longo L., Barone M., Romano R., Atti A.R., Barlati S., Deste G., Valsecchi P., Carpiniello B., Tusconi M., Puddu L., Signorelli M.S., Cannavo D., Minutolo G., Corbo M., Montemitro C., Baroni G., Altamura M., La Montagna M., Carnevale R., Murri M.B., Calcagno P., Bugliani M., Pizziconi G., Logozzo F., Rossi R., Giusti L., Salza A., Malavolta M., Orsenigo G., Grassi S., De Bartolomeis A., Gramaglia C., Gattoni E., Gambaro E., Tenconi E., Ferronato L., Collantoni E., Tonna M., Ossola P., Gerra M.L., Carmassi C., Cremone I.M., Carpita B., Buzzanca A., Girardi N., Frascarelli M., Del Casale A., Comparelli A., Corigliano V., Siracusano A., Di Lorenzo G., Ribolsi M., Corrivetti G., Bartoli L., Del Buono G., Fagiolini A., Bolognesi S., Goracci A., Mancini I., Bava I., Cardillo S., Bucci, P., Galderisi, S., Mucci, A., Rossi, A., Rocca, P., Bertolino, A., Aguglia, E., Amore, M., Andriola, I., Bellomo, A., Biondi, Maria, Cuomo, Anna, Dell'Osso, L., Favaro, A., Gambi, F., Giordano, G. M., Girardi, P., Marchesi, C., Monteleone, P., Montemagni, C., Niolu, C., Oldani, L., Pacitti, F., Pinna, F., Roncone, R., DE VITA, Anna, Zeppegno, P., Maj, M., Patriarca, Sara, Pietrafesa, Daria, Aiello, Carmen, Longo, Luisa, Barone, Marina, Romano, Raffaella, Atti, Anna Rita, Barlati, Stefano, Deste, Giacomo, Valsecchi, Paolo, Carpiniello, Bernardo, Tusconi, Massimo, Puddu, Laura, Signorelli, Maria Salvina, Cannavò, Dario, Minutolo, Giuseppe, Corbo, Mariangela, Montemitro, Chiara, Baroni, Gaia, Altamura, Mario, La Montagna, Maddalena, Carnevale, Raffaella, Murri, Martino Belvederi, Calcagno, Pietro, Bugliani, Michele, Pizziconi, Giulia, Logozzo, Francesca, Rossi, Rodolfo, Giusti, Laura, Salza, Anna, Malavolta, Maurizio, Orsenigo, Giulia, Grassi, Silvia, De Bartolomeis, Andrea, Gramaglia, Carla, Gattoni, Eleonora, Gambaro, Eleonora, Tenconi, Elena, Ferronato, Luisa, Collantoni, Enrico, Tonna, Matteo, Ossola, Paolo, Gerra, Maria Lidia, Carmassi, Claudia, Cremone, Ivan Mirko, Carpita, Barbara, Buzzanca, Antonio, Girardi, Nicoletta, Frascarelli, Marianna, Del Casale, Antonio, Comparelli, Anna, Corigliano, Valentina, Siracusano, Alberto, Di Lorenzo, Giorgio, Ribolsi, Michele, Corrivetti, Giulio, Bartoli, Luca, Del Buono, Gianfranco, Fagiolini, Andrea, Bolognesi, Simone, Goracci, Arianna, Mancini, Irene, Bava, Irene, Cardillo, Simona, Biondi, M., Cuomo, A., Vita, A., and Casale, Antonio
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Male ,avolition ,Severity of Illness Index ,cognitive functioning ,0302 clinical medicine ,Cognition ,Academic Performance ,Medicine ,Psychopathology ,Depression ,primary negative symptoms ,Middle Aged ,Psychiatric Status Rating Scale ,avolition, cognitive functioning, poor emotion expression, premorbid adjustment, primary negative symptoms ,poor emotion expression ,premorbid adjustment ,Psychiatry and Mental Health ,Memory, Short-Term ,Schizophrenia ,Female ,Schizophrenic Psychology ,medicine.symptom ,Psychosocial ,Social Adjustment ,Clinical psychology ,Human ,Adult ,primary negative symptom ,03 medical and health sciences ,Cognition Disorder ,Memory ,Social cognition ,Humans ,Cognitive Dysfunction ,Cognitive skill ,Social Behavior ,Aged ,Cognition Disorders ,Motivation ,Psychiatric Status Rating Scales ,Settore MED/25 - Psichiatria ,Avolition ,business.industry ,medicine.disease ,030227 psychiatry ,Short-Term ,business ,Neurocognitive ,030217 neurology & neurosurgery - Abstract
Objective The study aimed to explore premorbid academic and social functioning in patients with schizophrenia, and its associations with the severity of negative symptoms and neurocognitive impairment. Method Premorbid adjustment (PA) in patients with schizophrenia was compared to early adjustment in unaffected first-degree relatives and healthy controls. Its associations with psychopathology, cognition, and real-life functioning were investigated. The associations of PA with primary negative symptoms and their two factors were explored. Results We found an impairment of academic and social PA in patients (P ≤ 0.000001) and an impairment of academic aspects of early adjustment in relatives (P ≤ 0.01). Patients with poor PA showed greater severity of negative symptoms (limited to avolition after excluding the effect of depression/parkinsonism), working memory, social cognition, and real-life functioning (P ≤ 0.01 to ≤0.000001). Worse academic and social PA were associated with greater severity of psychopathology, cognitive impairment, and real-life functioning impairment (P ≤ 0.000001). Regression analyses showed that worse PA in the academic domain was mainly associated to the impairment of working memory, whereas worse PA in the social domain to avolition (P ≤ 0.000001). Conclusion Our findings suggest that poor early adjustment may represent a marker of vulnerability to schizophrenia and highlight the need for preventive/early interventions based on psychosocial and/or cognitive programs.
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- 2018
20. Dating protracted fault activities: microstructures, microchemistry and geochronology of the Vaikrita Thrust, Main Central Thrust zone, Garhwal Himalaya, NW India
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Montemagni, C, Montomoli, C, Iaccarino, S, Carosi, R, Jain, AK., Massonne, HJ, Villa, IM, Sharma, R, Villa, IM, Kumar, S, Montemagni, C, Montomoli, C, Iaccarino, S, Carosi, R, Jain, A, Massonne, H, and Villa, I
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GEO/08 - GEOCHIMICA E VULCANOLOGIA ,Ar-Ar geochronology, Himalaya, MCT ,GEO/03 - GEOLOGIA STRUTTURALE ,550 Earth sciences & geology - Abstract
The timing of shearing along the Vaikrita Thrust, the upper structural boundary of the Main Central Thrust Zone in the Garhwal Himalaya, was constrained by combined microstructural, microchemical and geochronological investigations. Three different biotite–muscovite growth and recrystallization episodes were observed: a relict mica-1; mica-2 along the main mylonitic foliation; and mica-3 in coronitic structures around garnet during its breakdown. Electron microprobe analyses of biotite showed chloritization and a bimodal composition of biotite-2 in one sample. Muscovite-2 and muscovite-3 differed in composition from each other. Biotite and muscovite39 Ar–40 Ar age spectra from all samples showed both inter-and intra-sample discrepancies. Biotite step-ages ranged between 8.6 and 16 Ma and muscovite step-ages between 3.6 and 7.8 Ma. These ages cannot be interpreted as ‘cooling ages’ because samples from the same outcrop cooled simultaneously. Instead, the Ar systematics reflect sample-specific recrystallization markers. Intergrown impurities were diagnosed by the Ca/K ratios. The age data of biotite were interpreted as a mixture of true biotite-2 (9.00 ± 0.10 Ma) and two alteration products. The negative Cl/K–age correlation identified a Cl-poor muscovite-2 (>7 Ma) and a Cl-rich, post-deformational, coronitic muscovite-3 grown at ≤5.88 ± 0.03 Ma. The Vaikrita Thrust was active at least from 9 to 6 Ma at c. 600°C; its movement had ended by 6 Ma.
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- 2019
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21. Geochronology and kinematics of flow of the Main Central Thrust zone in the Bhagirathi valley, NW Indian Himalaya
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Montemagni, C, Zanchetta, S, Montomoli, C, Iaccarino, S, Visonà, D, Villa IM, Carosi, R, Montemagni, C, Zanchetta, S, Montomoli, C, Iaccarino, S, Visonà, D, Villa, I, and Carosi, R
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GEO/08 - GEOCHIMICA E VULCANOLOGIA ,GEO/03 - GEOLOGIA STRUTTURALE ,MCTz, geochronology, vorticity - Abstract
The Himalayan belt has been long studied to deduce large-scale tectonics of shear zones regarding both their kinematics and the age of their timing, especially in the frame of exhumation of the Greater Himalayan Sequence (GHS), the metamorphic core of the orogenic belt. The GHS is delimited at its bottom by an orogenscale shear zone, the Main Central Thrust zone (MCTz), a top-to-the-SW km-thick zone of intensively sheared rocks. As quantitative vorticity analyses in deformed rocks and isotope dating are fundamental in the study of the kinematics of flow and time of activity in shear zones, four samples have been investigated to infer these parameters along the two tectonic boundaries of the MCTz in the Bhagirathi valley: the Munsiari (lower) and the Vaikrita Thrust (upper). To constrain the timing of deformations recorded within the Munsiari and Vaikrita Thrust rocks we undertook 40Ar/39Ar dating. We prepared biotite and muscovite separates with different degrees of purity in order to quantify the bias given by fine-grained impurity phases, which make 100% mica purity unattainable. Combining Argon Differential Release Plots (DRP) with EPMA and Ca-Cl-K signatures of each mica populations we identified the step ages dating deformation. Microstructures of the Munsiari Thrust show the occurrence of a main disjunctive foliation defined by biotite and minor muscovite. 40Ar/39Ar stepheating coupled with correlation diagrams constrains biotite growth on the main foliation at c. 5 Ma. The microstructures of mylonitic micaschists from the Vaikrita Thrust include three different textural generation of micas: a relict foliation, a main mylonitic foliation, and a late generation of static muscovite and chlorite overprinting the relict foliation. 40Ar/39Ar dating constrains muscovite growth on the main foliation around 10 Ma and the growth of large, static muscovite at c. 8 Ma. In the study area, Bhagirathi valley (NW India), our results support an in-sequence shearing from Vaikrita to Munsiari Thrust from c. 10 to c. 5 Ma. Adding information about the kinematic of flow to the age of the bounding shear zones of the GHS is a key purpose for its exhumation models. The use of stable porphyroclasts analysis used for vorticity estimates can suffer from severe limitations, because of the reduction to two dimensions of motion of rigid clasts that is a complex 3D problem. We propose an alternative method to acquire data based on the use of X-ray micro computed tomography that allows to considerably decrease the limitation of the method. We selected the mylonitic orthogneisses from the Munsiari Thrust containing K-feldspar porphyroclasts in order to estimate the kinematic vorticity, which ranges between 0.49 and 0.57. We stress here the importance of a multidisciplinary approach based on detailed meso and microstructural, chemical and geochronological investigations of pervasively sheared rocks from shear zones having multiple generations of fine-grained foliations.
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- 2019
22. Geology and tectono-metamorphic history of the Himalayan metamorphic core: insights from the Alaknanda-Dhauli Ganga valleys (NW India)
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Iaccarino, S, Carosi, R, Montomoli, C, Montemagni, C, Massonne, H-J, Jain, AK, Visonà, D, Iaccarino, S, Carosi, R, Montomoli, C, Montemagni, C, Massonne, H, Jain, A, and Visonà, D
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GEO/03 - GEOLOGIA STRUTTURALE ,Himalaya, P-T-d-t paths, metamorphisms, shear zone - Abstract
In the Alaknanda-Dhauli Ganga valleys (Garhwal Himalaya, NW India) a nearly complete crustal- structural section of the Himalaya crops out (Jain et al., 2014). In this contribution we present field observations, as well as, microstructural, petrological and geochronological data from the Lesser Himalayan Sequences up to the Tethyan Himalayan Sequence from this area. The pressure-temperature-deformation-time history (i.e. the P-T-d-t path) of selected samples from the Main Central Thrust zone (MCTz) and the up to ductile-sheared portion of the South Tibetan Detachment System (STDS) has been reconstructed with the aid of equilibrium assemblage diagrams, coupled with multiequilibrium and trace-element based thermobarometry after detailed electron microprobe analytical work and microstructural analysis have been performed. U-Th-Pb in situ monazite geochronology from selected samples of key-structural positions (MCTZ up to STDS) allowed us to put an absolute temporal constraint both on the prograde metamorphic history and on the exhumation-related overprint. These data, joined with the geological literature (e.g. Thakur et al., 2015; Hunter et al., 2018), shed light on the tectono-metamorphic evolution of the Himalayan metamorphic core in this portion of the belt. Moreover, these new P-T-d-t paths could be quite well compared with data from other portions of the belt located in Central and Central-Western Nepal (e.g. Iaccarino et al., 2017), since the same approach was followed. Hunter N.J.R., Weinberg R.F., Wilson CJ.L., Luzin W. & Misra S. (2018) - Microscopic anatomy of a “hot-on-cold” shear zone: Insights from quartzites of the Main Central Thrust in the Alaknanda region (Garhwal Himalaya). GSA Bulletin, 130, 1519-1539. Iaccarino S., Montomoli C., Carosi R., Massonne H.-J., Visonà D. (2017) - Geology and tectono-metamorphic evolution of the Himalayan metamorphic core: insights from the Mugu Karnali transect, Western Nepal (Central Himalaya). J. Metam. Geol., 35, 301-325. Jain A.K., Shreshtha M., Seth P., Kanyal L., Carosi R., Montomoli C., Iaccarino S. & Mukherjee P.K. (2014) - The Higher Himalayan Crystallines, Alaknanda – Dhauli Ganga Valleys, Garhwal Himalaya, India. J. Virtual Explorer, 47, Paper 8. Thakur S.S., Patel S.C. & Singh A.K. (2015) - A P-T pseudosection modelling approach to understand metamorphic evolution of the Main Central Thrust Zone in the Alaknanda valley, NW Himalaya. Contrib. Mineral. Petrol., 170, 1-26.
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- 2019
23. Familial aggregation of MATRICS Consensus Cognitive Battery scores in a large sample o outpatients with schizophrenia and their unaffected relatives
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Mucci A., Galderisi S., Green M. F., Nuechterlein K., Rucci P., Gibertoni D., Rossi A., Rocca P., Bertolino A., Bucci P., Hellemann G., Spisto M., Palumbo D., Aguglia E., Amodeo G., Amore M., Bellomo A., Brugnoli R., Carpiniello B., Dell'osso L., Di Fabio F., Di Giannantonio M., Di Lorenzo G., Marchesi C., Monteleone P., Montemagni C., Oldani L., Romano R., Roncone R., Stratta P., Tenconi E., Vita A., Zeppegno P., Maj M., Piegari G., Vignapiano A., Caputo F., Plescia G., Montefusco V., Mancini M., Attrotto M. T., Paladini V., Atti A. R., Barlati S., Galluzzo A., Mussoni C., Pinna F., Sanna L., Primavera D., Signorelli M. S., Minutolo G., Cannavo D., Acciavatti T., Santacroce R., Corbo M., Altamura M., La Montagna M., Carnevale R., Pizziconi G., Rossi R., Santarelli V., Giusti L., Malavolta M., Salza A., Murri M. B., Calcagno P., Bugliani M., Serati M., Orsenigo G., Gramaglia C., Gattoni E., Cattaneo C., Campagnola N., Ferronato L., Piovan C., Tonna M., Bettini E., Ossola P., Gesi C., Landi P., Rutigliano G., Biondi M., Girardi P., Buzzanca A., Zocconali M., Comparelli A., Mancinelli I., Niolu C., Ribolsi M., Siracusano A., Corrivetti G., Bartoli L., Diasco F., Bolognesi S., Goracci A., Fagiolini A., Bellino S., Cardillo S., Bracale N., Mucci, A., Galderisi, S., Green, M. F., Nuechterlein, K., Rucci, P., Gibertoni, D., Rossi, A., Rocca, P., Bertolino, A., Bucci, P., Hellemann, G., Spisto, M., Palumbo, D., Aguglia, E., Amodeo, G., Amore, M., Bellomo, A., Brugnoli, R., Carpiniello, B., Dell'Osso, L., Di Fabio, F., Di Giannantonio, M., Di Lorenzo, G., Marchesi, C., Monteleone, P., Montemagni, C., Oldani, L., Romano, R., Roncone, R., Stratta, P., Tenconi, E., Vita, A., Zeppegno, P., Maj, M., Piegari, G., Vignapiano, A., Caputo, F., Plescia, G., Montefusco, V., Mancini, M., Attrotto, M. T., Paladini, V., Atti, A. R., Barlati, S., Galluzzo, A., Mussoni, C., Pinna, F., Sanna, L., Primavera, D., Signorelli, M. S., Minutolo, G., Cannavo, D., Acciavatti, T., Santacroce, R., Corbo, M., Altamura, M., La Montagna, M., Carnevale, R., Pizziconi, G., Rossi, R., Santarelli, V., Giusti, L., Malavolta, M., Salza, A., Murri, M. B., Calcagno, P., Bugliani, M., Serati, M., Orsenigo, G., Gramaglia, C., Gattoni, E., Cattaneo, C., Campagnola, N., Ferronato, L., Piovan, C., Tonna, M., Bettini, E., Ossola, P., Gesi, C., Landi, P., Rutigliano, G., Biondi, M., Girardi, P., Buzzanca, A., Zocconali, M., Comparelli, A., Mancinelli, I., Niolu, C., Ribolsi, M., Siracusano, A., Corrivetti, G., Bartoli, L., Diasco, F., Bolognesi, S., Goracci, A., Fagiolini, A., Bellino, S., Cardillo, S., Bracale, N., and di Giannantonio, M.
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Attention, MCCB Italian standardization, reasoning and problem solving, social cognition, verbal learning, working memory ,Proband ,Adult ,Male ,Consensus ,Psychometrics ,Context (language use) ,social cognition ,Verbal learning ,working memory ,03 medical and health sciences ,Attention ,MCCB Italian standardization ,reasoning and problem solving ,verbal learning ,Aged ,Cognition ,Cognitive Dysfunction ,Family ,Female ,Humans ,Middle Aged ,Outpatients ,Psychiatric Status Rating Scales ,Schizophrenia ,Schizophrenic Psychology ,0302 clinical medicine ,Social cognition ,medicine ,Applied Psychology ,Psychiatry and Mental Health ,Family aggregation ,medicine.disease ,030227 psychiatry ,Settore MED/25 ,Psychology ,MATRICS ,Neurocognitive ,030217 neurology & neurosurgery ,Clinical psychology - Abstract
BackgroundThe increased use of the MATRICS Consensus Cognitive Battery (MCCB) to investigate cognitive dysfunctions in schizophrenia fostered interest in its sensitivity in the context of family studies. As various measures of the same cognitive domains may have different power to distinguish between unaffected relatives of patients and controls, the relative sensitivity of MCCB tests for relative–control differences has to be established. We compared MCCB scores of 852 outpatients with schizophrenia (SCZ) with those of 342 unaffected relatives (REL) and a normative Italian sample of 774 healthy subjects (HCS). We examined familial aggregation of cognitive impairment by investigating within-family prediction of MCCB scores based on probands’ scores.MethodsMultivariate analysis of variance was used to analyze group differences in adjusted MCCB scores. Weighted least-squares analysis was used to investigate whether probands’ MCCB scores predicted REL neurocognitive performance.ResultsSCZ were significantly impaired on all MCCB domains. REL had intermediate scores between SCZ and HCS, showing a similar pattern of impairment, except for social cognition. Proband's scores significantly predicted REL MCCB scores on all domains except for visual learning.ConclusionsIn a large sample of stable patients with schizophrenia, living in the community, and in their unaffected relatives, MCCB demonstrated sensitivity to cognitive deficits in both groups. Our findings of significant within-family prediction of MCCB scores might reflect disease-related genetic or environmental factors.
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- 2018
24. The complex relationship between self-reported 'personal recovery' and clinical recovery in schizophrenia
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Rossi, A, Amore, M, Galderisi, S, Rocca, P, Bertolino, A, Aguglia, E, Amodeo, G, Bellomo, A, Bucci, P, Buzzanca, A, Carpiniello, B, Comparelli, A, Dell'Osso, L, Giannantonio, M, Mancini, M, Marchesi, C, Monteleone, P, Montemagni, C, Oldani, L, Roncone, R, Siracusano, A, Stratta, P, Tenconi, E, Vignapiano, A, Vita, A, Zeppegno, P, Maj, M, Rossetti, M, Rossi, R, Santarelli, V, Giusti, L, Malavolta, M, Salza, A, Palumbo, D, Patriarca, S, Chieffi, M, Attrotto, M, Colagiorgio, L, Andriola, I, Atti, A, Barlati, S, Deste, G, Galluzzo, A, Pinna, F, Deriu, L., Sanna, L, Signorelli, M., Minutolo, G, Cannavò, D, Martinotti, G, Acciavatti, T, Corbo, M, Altamura, M, Carnevale, R, Malerba, S, Murri, M, Calcagno, P, Bugliani, M, Serati, M, Bartolomeis, A, Gramaglia, C, Gattoni, E, Gambaro, E, Collantoni, E, Cremonese, C, Rossi, E, Ossola, P, Tonna, M, Panfilis, C, Rutigliano, G, Gesi, C, Carmassi, C, Biondi, M, Girardi, P, Brugnoli, R, Fabio, F, Pietro, S, Girardi, N, Niolu, C, Lorenzo, G, Ribolsi, M, Corrivetti, G, Pinto, G, Longobardi, N, Fagiolini, A, Goracci, A, Bolognesi, S, Bellino, S, Villari, V, Bracale, N, Rossi, A., Amore, M., Galderisi, S., Rocca, P., Bertolino, A., Aguglia, E., Amodeo, G., Bellomo, A., Bucci, P., Buzzanca, A., Carpiniello, B., Comparelli, A., Dell'Osso, L., Giannantonio, M. D., Mancini, M., Marchesi, C., Monteleone, P., Montemagni, C., Oldani, L., Roncone, R., Siracusano, A., Stratta, P., Tenconi, E., Vignapiano, A., Vita, A., Zeppegno, P., Maj, M., Rossetti, M. C., Rossi, R., Santarelli, V., Giusti, L., Malavolta, M., Salza, A., Palumbo, D., Patriarca, S., Chieffi, M., Attrotto, M. T., Colagiorgio, L., Andriola, I., Atti, A. R., Barlati, S., Deste, G., Galluzzo, A., Pinna, F., Deriu, L., Sanna, L., Signorelli, M. S., Minutolo, G., Cannavo, D., Martinotti, G., Acciavatti, T., Corbo, M., Altamura, M., Carnevale, R., Malerba, S., Murri, M. B., Calcagno, P., Bugliani, M., Serati, M., Bartolomeis, A., Gramaglia, C., Gattoni, E., Gambaro, E., Collantoni, E., Cremonese, C., Rossi, E., Ossola, P., Tonna, M., Panfilis, C. D., Rutigliano, G., Gesi, C., Carmassi, C., Biondi, M., Girardi, P., Brugnoli, R., Fabio, F. D., Pietro, S. D., Girardi, N., Niolu, C., Lorenzo, G. D., Ribolsi, M., Corrivetti, G., Pinto, G., Longobardi, N., Fagiolini, A., Goracci, A., Bolognesi, S., Bellino, S., Villari, V., and Bracale, N.
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Adult ,Male ,Schizophrenia, Personal recovery, Clinical recovery, Insight, Recovery styles, Cluster analysis ,Clinical recovery ,Coping (psychology) ,Cross-sectional study ,Recovery style ,03 medical and health sciences ,Diagnostic Self Evaluation ,0302 clinical medicine ,Cluster analysis ,Recovery styles ,Insight ,Personal recovery ,Schizophrenia ,Cluster Analysis ,Cross-Sectional Studies ,Female ,Humans ,Psychiatric Status Rating Scales ,Self Report ,Recovery of Function ,Schizophrenic Psychology ,Cluster analysi ,Self report ,Settore MED/25 - Psichiatria ,Biological Psychiatry ,030227 psychiatry ,Psychiatry and Mental Health ,Psychiatric status rating scales ,Biological psychiatry ,Psychology ,030217 neurology & neurosurgery ,Clinical psychology - Abstract
Self-reported 'personal recovery' and clinical recovery in schizophrenia (SRPR and CR. respectively) reflect different perspectives in schizophrenia outcome, not necessarily concordant with each other and usually representing the consumer's or the therapist's point of view. By means of a cluster analysis on SRPR related variables, we identified three dusters. The first and third cluster included subjects with the best and the poorest clinical outcome respectively. The second cluster was characterized by better insight, higher levels of depression and stigma, lowest self-esteem and personal strength, and highest emotional coping. The first duster showed positive features of recovery, while the third duster showed negative features. The second cluster, with the most positive insight, showed a more complex pattern, a some-what 'paradoxical' mixture of positive and negative personal and clinical features of recovery. The present results suggest the need for a characterization of persons with schizophrenia along SRPR and CR dimensions to design individualized and integrated treatment programs aimed to improve insight and coping strategies, reduce stigma and shape recovery styles. (C) 2017 Elsevier B.V. All rights reserved.
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- 2018
25. Inverted metamorphic gradient in large-hot orogens: The case of the Main Central Thrust zone in the Alaknanda-Dhauli Ganga Valleys, Garhwal Himalaya, India
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Iaccarino, S, Montomoli, C, Carosi, R, Montemagni, C, Massonne, HJ, Jain, AK, Villa, IM, Visonà, D, Iaccarino, S, Montomoli, C, Carosi, R, Montemagni, C, Massonne, H, Jain, A, Villa, I, and Visonà, D
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Garhwal Himalaya, MCTz, geothermobarometry, U-Th-Pb dating - Published
- 2018
26. The Himalayan metamorphic core along the Alaknanda-Dhauli Ganga valley (Garhwal Himalaya, India)
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Iaccarino, S, Carosi, R, Montomoli, C, Montemagni, C, Massonne, HJ, Jain, AK, Villa, IM, Visonà, D, Iaccarino, S, Carosi, R, Montomoli, C, Montemagni, C, Massonne, H, Jain, A, Villa, I, and Visonà, D
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Garhwal Himalaya, GHS, inverted metamorphism, monazite, geochronology - Published
- 2018
27. Microstructural and geochronological investigations of the Main Central Thrust zone and the South Tibetan Detachment System in the Alaknanda – Dhauli Ganga valleys (NW India)
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Montemagni, C, Carosi, R, Iaccarino, S, Montomoli, C, Jain, AK, Villa, IM, Montemagni, C, Carosi, R, Iaccarino, S, Montomoli, C, Jain, A, and Villa, I
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Himalaya, MCT, STDS, Ar/Ar dating, geochronology - Abstract
Shear zones play a major role in the tectonic evolution of the orogens and in the exhumation of crystalline rocks. In the Himalaya, two crustal scale shear zones having opposite kinematics bound the Greater Himalayan Sequence (GHS), the metamorphic core of the orogen, along the entire belt: the Main Central Thrust zone (MCTz) and the South Tibetan Detachment System (STDS). The activity time-span of these shear zones has been addressed by many studies, which unsurprisingly give very scattered results, as each study focused on different geological features and followed different mapping, sampling, analytical and interpretive strategies. In the Alaknanda – Dhauli Ganga valleys (Garhwal, NW India) both the STDS and the MCTz crop out in the same transect. The MCTz is a > 1-km thick zone delimited by two distinct thrusts, the Munsiari Thrust at the base and the Vaikrita Thrust, the MCT sensu stricto in the study area, at the top. We selected three representative samples from the Vaikrita Thrust, which crops out in the South of the transect, and three from the the STDS, which crops out in the North of the study area, in order to compare the timing of their activity along the same transect using the same analytical and interpretive approach. Microstructural observations on one garnet-staurolite-bearing quartzite and two garnet-bearing mylonitic micaschists from the Vaikrita Thrust prove the occurrence of three different textural generation of micas: a rare relict foliation, a main mylonitic foliation, and a late generation of static micas forming coronites after garnet breakdown. 40Ar/39Ar step-heating coupled with EMP analyses and with Ca-Cl-K correlation diagrams constrains mica growth on the main foliation around 9 Ma, and coronitic micas at c. 6 Ma (Montemagni et al. 2018b). The STDS deforms the small Malari granite. Deformation microstructures vary according to structural level. In the uppermost sample, a pegmatite intruding the Malari main body, low temperature deformation features are expressed by bulging recrystallization in quartz, bent twins in plagioclase, and kink bands in muscovite. 40Ar/39Ar dating on muscovite give 16.46 ± 0.06 Ma. Structurally below, another pegmatite, intruding the HT-mylonites, was formed during a later, waning deformation stage. Mica shows undulose extinction in quartz and rare kink bands, and yields a younger 40Ar/39Ar age of c. 16.0 Ma. The structurally lowest sillimanite-bearing migmatite shows high temperature deformation microstructures (chessboard extinction and grain boundary migration recrystallization in quartz), followed by static growth of undeformed muscovite, which yields a 40Ar/39Ar age of 14.36 ± 0.06 Ma. This is the minimum age for the cessation of ductile deformation (Montemagni et al. 2018a). Our results demonstrate a diachroneity of STDS and MCT in the Garhwal Himalaya. Any model of exhumation of the GHS should account for this lack of contemporaneity. Montemagni C. et al. (2018a) It. J. Geosci., doi: 10.3301/IJG.2018.07 - Montemagni C. et al. (2018b) Geol. Soc. London Spec. Pub., doi: 10.1144/SP481.3
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- 2018
28. Microstructural, petrological, microchemical and geochronological investigation of the Main Central Thrust zone in the Garhwal Himalaya, NW India
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Montemagni C., Montomoli C., Carosi R., Iaccarino S., Jain A. K., Massonne H-J., Villa I. M., Montemagni, C, Montomoli, C, Carosi, R, Iaccarino, S, Jain, A, Massonne, H, and Villa, I
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GEO/08 - GEOCHIMICA E VULCANOLOGIA ,GEO/03 - GEOLOGIA STRUTTURALE ,NW Himalaya, Main Central Thrust, 40Ar/39Ar geochronology - Published
- 2017
29. Pressure-Temperature-Deformation-Time Constraints on the South Tibetan Detachment System in the Garhwal Himalaya (NW India)
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Iaccarino, S., Montomoli, C., Carosi, R., Montemagni, C., Massonne, H. -J., Langone, A., Jain, A. K., Visonà, D., Iaccarino, S, Montomoli, C, Carosi, R, Montemagni, C, Massonne, H, Langone, A, Jain, A, and Visonà, D
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Geophysics ,Geochemistry and Petrology ,P-T-D-t path ,Garhwal geology ,Himalaya ,low-angle normal faults ,monazite geochronology ,South Tibetan Detachment System ,Geophysic ,low-angle normal fault - Abstract
A peculiar feature of the Himalaya is the occurrence of a system of low-angle normal faults and shear zones, the South Tibetan Detachment System (STDS), at the mountain crests. The STDS was active during synconvergent tectonics. We describe the STDS-related sheared rocks along the Dhauli Ganga valley, in the Garhwal Himalaya (NW India), where the Malari granite, reported as an undeformed igneous body crosscutting the STDS, occurs. A detailed multidisciplinary study, integrating field-based, microstructural, petrographic, and geochronological analyses, was carried out on rocks along this valley. We demonstrate how the noncoaxial ductile portion of the STDS affected the upper part of the Greater Himalaya Sequence migmatite, which experienced peak pressure (P)-temperature (T) conditions of 0.9â1.1 GPa and â¥750°C at â¥24 Ma. This migmatite has been reworked structurally upward leading to the formation of high-T sillimanite-bearing mylonites. Further upward, medium-T shearing deformed the Malari granite and leucogranite dykes, forming medium-T mylonites. Ductile shearing was temporally constrained, based on new in situ monazite datings and previously published Ar-Ar geochronology, between ~20 and 15 Ma. We demonstrate that a preserved ductile to brittle spatial and temporal transition of the STDS deformation exists, with the brittle features overprinting ductile ones. Our data shed new light on the geological evolution of the STDS in the NW Himalaya with implications for the relationship and relative timing of partial melting, granite emplacement, and deformation along low-angle normal faults.
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- 2017
30. Pathways to functional outcome in subjects with schizophrenia living in the community and their unaffected first-degree relatives
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Galderisi, S, Rossi, A, Rocca, P, Bertolino, A, Mucci, A, Bucci, P, Rucci, P, Gibertoni, D, Aguglia, E, Amore, M, Blasi, G, Comparelli, A, Di Giannantonio, M, Goracci, A, Marchesi, C, Monteleone, P, Montemagni, C, Pinna, F, Roncone, R, Siracusano, A, Stratta, P, Torti, M, Vita, A, Zeppegno, P, Chieffi, M, Maj, M, Piegari, G, Merlotti, E, Rocco, M, Campana, T, Plescia, G, Montefusco, V, Porcelli, S, Barlati, S, Carpiniello, B, Signorelli, M, Acciavatti, T, Bellomo, A, Respino, M, Di Emidio, G, Giusti, L, Oldani, L, Tomasetti, C, Tenconi, E, Ossola, P, Dell'Osso, L, Squarcione, C, Brugnoli, R, Niolu, C, Bartoli, L, Bolognesi, S, Frieri, T, Galderisi, Silvana, Rossi, Alessandro, Rocca, Paola, Bertolino, Alessandro, Mucci, Armida, Bucci, Paola, Rucci, Paola, Gibertoni, Dino, Aguglia, Eugenio, Amore, Mario, Blasi, Giuseppe, Comparelli, Anna, Di Giannantonio, Massimo, Goracci, Arianna, Marchesi, Carlo, Monteleone, Palmiero, Montemagni, Cristiana, Pinna, Federica, Roncone, Rita, Siracusano, Alberto, Stratta, Paolo, Torti, Maria Chiara, Vita, Antonio, Zeppegno, Patrizia, Chieffi, Marcello, and Maj, Mario
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Adult ,Employment ,Male ,medicine.medical_specialty ,Social Stigma ,Interpersonal relationships ,Models, Psychological ,Avolition ,Cognition ,Schizophrenia first-degree relatives ,Structural equation model ,Work skills ,Psychiatry and Mental Health ,Biological Psychiatry ,03 medical and health sciences ,0302 clinical medicine ,Work skill ,Social cognition ,medicine ,Humans ,Family ,Genetic Predisposition to Disease ,Interpersonal Relations ,First-degree relatives ,Psychiatry ,Settore MED/25 - Psichiatria ,Psychiatric Status Rating Scales ,Models, Statistical ,medicine.disease ,Interpersonal relationship ,030227 psychiatry ,Psychiatry and Mental health ,Schizophrenia ,Educational Status ,Schizophrenia first-degree relative ,Female ,Schizophrenic Psychology ,medicine.symptom ,Biological psychiatry ,Psychology ,Neurocognitive ,030217 neurology & neurosurgery ,Psychopathology ,Clinical psychology - Abstract
Rationale Variables influencing real-life functioning have repeatedly been modeled in schizophrenia subjects but not systematically investigated in their unaffected first-degree relatives (SRs), in whom milder forms of deficits reported in schizophrenia have been observed, but confounders of clinical cohorts are not in play. Demonstrating that pathways to functional outcome are similar between patients and SRs would validate structural models developed in schizophrenia subjects. The present multicenter study aimed to explore whether variables associated with real-life functioning are similar in schizophrenia patients and their unaffected relatives. Methods The study sample included 921 schizophrenia patients, 379 SRs and 780 healthy controls. Structural Equation Models (SEMs) were used in patients and SRs to test associations of psychopathological dimensions, neurocognition, social cognition, resilience, perceived stigma and functional capacity with real-life functioning domains, impaired in both patients and SRs. Results Interpersonal Relationships and Work Skills were the only functional domains impaired in both patients and SRs. For both domains, functional impairment in patients was found to predict impairment in unaffected relatives, suggesting the involvement of similar illness-related vulnerability factors. In both groups variables significantly associated with Interpersonal Relationships included Social Cognition, Neurocognition, Avolition, Resilience, Disorganization, Perceived Stigma and Gender, and those significantly associated with Work Skills included Social Cognition, Neurocognition and Disorganization. Conclusions Pathways to functional outcome for Interpersonal relationships and Work skills are similar between schizophrenia patients and their unaffected first-degree relatives. These findings validate, in the absence of confounders of clinical cohorts, structural models of determinants of functional outcome in people with schizophrenia.
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- 2016
31. Disorganization and real-world functioning in schizophrenia: Results from the multicenter study of the Italian Network for Research on Psychoses
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Rocca, P., primary, Galderisi, S., additional, Rossi, A., additional, Bertolino, A., additional, Rucci, P., additional, Gibertoni, D., additional, Montemagni, C., additional, Bellino, S., additional, Aguglia, E., additional, Amore, M., additional, Bellomo, A., additional, Biondi, M., additional, Carpiniello, B., additional, Cuomo, A., additional, D'Ambrosio, E., additional, dell'Osso, L., additional, Girardi, P., additional, Marchesi, C., additional, Monteleone, P., additional, Montemitro, C., additional, Oldani, L., additional, Pacitti, F., additional, Roncone, R., additional, Siracusano, A., additional, Tenconi, E., additional, Vita, A., additional, Zeppegno, P., additional, Steardo, L., additional, Vignapiano, A., additional, Maj, M., additional, Bracale, Nadja, additional, Cardillo, Simona, additional, Brasso, Claudio, additional, Andriola, Ileana, additional, Romano, Raffaella, additional, Caforio, Grazia, additional, Barlati, Stefano, additional, Galluzzo, Alessandro, additional, Deste, Giacomo, additional, Pinna, Federica, additional, Lostia di S. Sofia, Silvia, additional, Lai, Alice, additional, Signorelli, Maria Salvina, additional, Corbo, Mariangela, additional, Baroni, Gaia, additional, Lupi, Matteo, additional, Altamura, Mario, additional, La Montagna, Maddalena, additional, Malerba, Stefania, additional, Murri, Martino Belvederi, additional, Corso, Alessandro, additional, Bugliani, Michele, additional, Pizziconi, Giulia, additional, Rossi, Rodolfo, additional, Serrone, Dario, additional, Giusti, Laura, additional, Ussorio, Donatella, additional, Salza, Anna, additional, Merlotti, Eleonora, additional, Piegari, Giuseppe, additional, Patriarca, Sara, additional, Pietrafesa, Daria, additional, de Bartolomeis, Andrea, additional, Gramaglia, Carla, additional, Gattoni, Eleonora, additional, Marangon, Debora, additional, Grottaroli, Marika, additional, Pigoni, Alessandro, additional, Grassi, Silvia, additional, Cremonese, Carla, additional, Meneguzzo, Paolo, additional, Collantoni, Enrico, additional, Tonna, Matteo, additional, Ossola, Paolo, additional, Gerra, Maria Lidia, additional, Gesi, Camilla, additional, Cremone, IvanMirko, additional, Carpita, Barbara, additional, Brugnoli, Roberto, additional, Comparelli, Anna, additional, Corigliano, Valentina, additional, Di Fabio, Fabio, additional, Buzzanca, Antonio, additional, Girardi, Nicoletta, additional, Niolu, Cinzia, additional, Di Lorenzo, Giorgio, additional, Ribolsi, Michele, additional, Corrivetti, Giulio, additional, Bartoli, Luca, additional, Diasco, Ferdinando, additional, Fagiolini, Andrea, additional, Bolognesi, Simone, additional, and Goracci, Arianna, additional
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- 2018
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32. Deformation and fluid flow in the Munsiari Thrust (NW India): A preliminary fluid inclusion study
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Montemagni, C., Fulignati, Paolo, Iaccarino, Salvatore, Marianelli, Paola, Montomoli, Chiara, Sbrana, Alessandro, Montemagni, C, Fulignati, P, Iaccarino, S, Marianell, P, Montomoli, C, and Sbrana, A
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Fluid inclusions, Fluids and metamorphism, Garhwal Himalaya, Main central thrust, Munsiari Thrust ,Fluids and metamorphism ,Main central thrust ,Agricultural and Biological Sciences (all) ,GEO/08 - GEOCHIMICA E VULCANOLOGIA ,GEO/03 - GEOLOGIA STRUTTURALE ,Garhwal Himalaya ,Fluid inclusions ,Munsiari Thrust ,Earth and Planetary Sciences (all) ,Fluid inclusion - Abstract
Deformation and fuid flow in the Munsiari Thrust (NW India): a preliminary fluid inclusion study. A fluid inclusion study was carried out on quartz veins deformed during the activity of the Munsiari Thrust in the Garhwal Himalaya (NW India, Western Himalaya). These veins are hosted in mylonitic phyllites, with a greenschist mineral assemblage made of quartz-white mica-biotite-chlorite-epidote and minor calcite and plagioclase. Within the veins two groups of isolated "early fluid" inclusions and trails of small secondary fluid inclusions have been observed. Two types of inclusions preserved in isolated groups have been petrographycally recognized: (i) a two liquids and a vapor phase (L1+L2+V) that is the most common type and (ii) a less frequent liquid and a vapor phase (L+V). Both types of fluid inclusions were investigated through optical microthermometric experiments. For "early fluid" inclusions, assuming a trapping temperature based on quartz dynamic recrystallization mechanisms and previous P-T estimates, in the range of 500-520°C, a corresponding trapping pressure in the range of c. 0.50-0.53 GPa is estimated. The trapping pressure range evaluated in the present contribution support that these fluid inclusions have been entrapped during the early stages of the activity of the Munsiari Thrust.
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- 2016
33. Social cognition in people with schizophrenia: a cluster-analytic approach
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Rocca, P., Galderisi, S., Rossi, A., Bertolino, A., Rucci, P., Gibertoni, D., Montemagni, C., Sigaudo, M., Mucci, A., Bucci, P., Acciavatti, T., Aguglia, E., Amore, M., Bellomo, A., Deronchi, D., Osso, L., Difabio, F., Girardi, P., Goracci, A., Marchesi, C., Monteleone, P., Niolu, C., Pinna, F., Roncone, R., EMILIO SACCHETTI, Santonastaso, P., Zeppegno, P., Maj, M., Chieffi, M., Piegari, M., Vignapiano, A., Merlotti, E., Plescia, G., Montefusco, V., Bava, I., Mancini, I., Sandei, L., Antoniettanettis, I., Rizzo, G., Mancini, M., Porcelli, S., Salfi, G., Bianchini, O., Antonio Vita, Galluzzo, G., Barlati, S., Carpiniello, B., Primavera, D., Floris, S., Salvina, Signorelli, Minutolo, B., Cannavò, G., Corbo, D., Vellante, M., Alessandrini, F., Poli, M., Altamura, M., Petito, M., Marasco, A., Vaggi, D., Calcagno, M., Marozzi, P., Ussorio, V., Giusti, D., Malavolta, L., Diemidio, M., Stratta, G., Collazzoni, P., Debartolomeis, P., Gramaglia, P., Gili, C., Gattoni, S., Ferronato, E., Giannunzio, L., Tenconi, V., Tonna, E., Ossola, M., Camerlengo, P., Landi, E., Rutigliano, P., Buzzanca, G., Paolemili, A., Frascarelli, M., Comparelli, M., Corigliano, A., Brugnoli, V., Siracusano, R., Troisi, A., Dilorenzo, A., Filippo, Di, Longobardi, C., Castaldo, N., Fagiolini, E., Bolognesi, A., Capua, De, A, DIPARTIMENTO DI SCIENZE BIOMEDICHE E NEUROMOTORIE, Facolta' di MEDICINA e CHIRURGIA, AREA MIN. 06 - Scienze mediche, Da definire, Rocca, P, Galderisi, S., Rossi, A., Bertolino, A., Rucci, P., Gibertoni, D., Montemagni, C., Sigaudo, M., Mucci, A., Bucci, P., Acciavatti, T., Aguglia, E., Amore, M., Bellomo, A., De Ronchi, D., Dell'Osso, L., Di Fabio, F., Girardi, P., Goracci, A., Marchesi, C., Monteleone, P., Niolu, C., Pinna, F., Roncone, R., Sacchetti, E., Santonastaso, P., Zeppegno, P., Maj, M., Rocca, P., Chieffi, M., Piegari, M., Vignapiano, A., Merlotti, E., Plescia, G., Montefusco, V., Bava, I., Mancini, I., Sandei, L., Antonietta Nettis, I., Rizzo, G., Mancini, M., Porcelli, S., Salfi, G., Bianchini, O., Vita, A., Galluzzo, G., Barlati, S., Carpiniello, B., Primavera, D., Floris, S., Salvina Signorelli, B., Minutolo, G., Cannavo, D., Corbo, M., Vellante, F., Alessandrini, M., Poli, M., Altamura, M., Petito, A., Marasco, D., Vaggi, M., Calcagno, P., Marozzi, V., Ussorio, D., Giusti, L., Malavolta, M., Di Emidio, G., Stratta, P., Collazzoni, P., De Bartolomeis, P., Gramaglia, C., Gili, S., Gattoni, E., Ferronato, L., Giannunzio, V., Tenconi, E., Tonna, M., Ossola, P., Camerlengo, E., Landi, P., Rutigliano, G., Buzzanca, A., Paolemili, M., Frascarelli, M., Comparelli, A., Corigliano, V., Brugnoli, R., Siracusano, A., Troisi, A., Di Lorenzo, G., Di Filippo, C., Longobardi, N., Castaldo, E., Fagiolini, A., Bolognesi, S., De Capua, A., and Italian Network for Research on, Psychoses
- Subjects
Adult ,Male ,Context (language use) ,social cognition ,Italian Network for Research on Psychoses ,03 medical and health sciences ,0302 clinical medicine ,Cluster analysis ,Social cognition ,Emotion perception ,medicine ,schizophrenia ,theory of mind ,Cluster Analysis ,Emotional Intelligence ,Facial Recognition ,Female ,Humans ,Middle Aged ,Schizophrenia ,Facial Expression ,Social Perception ,Wit and Humor as Topic ,Applied Psychology ,Psychiatry and Mental Health ,Cluster analysis Italian Network for Research on Psychosesschizophrenia social cognition theory of mind ,Cluster analysi ,Italian Network for Research on Psychose ,Settore MED/25 - Psichiatria ,Facial expression ,Social perception ,Emotional intelligence ,medicine.disease ,cluster analysis ,italian network for research on psychoses ,adult ,emotional intelligence ,facial recognition ,female ,humans ,male ,middle aged ,facial expression ,social perception ,wit and humor as topic ,applied psychology ,psychiatry and mental health ,030227 psychiatry ,Psychology ,Neurocognitive ,030217 neurology & neurosurgery ,Clinical psychology - Abstract
none 28 no BACKGROUND: The study aimed to subtype patients with schizophrenia on the basis of social cognition (SC), and to identify cut-offs that best discriminate among subtypes in 809 out-patients recruited in the context of the Italian Network for Research on Psychoses. METHOD: A two-step cluster analysis of The Awareness of Social Inference Test (TASIT), the Facial Emotion Identification Test and Mayer-Salovey-Caruso Emotional Intelligence Test scores was performed. Classification and regression tree analysis was used to identify the cut-offs of variables that best discriminated among clusters. RESULTS: We identified three clusters, characterized by unimpaired (42%), impaired (50.4%) and very impaired (7.5%) SC. Three theory-of-mind domains were more important for the cluster definition as compared with emotion perception and emotional intelligence. Patients more able to understand simple sarcasm (⩾14 for TASIT-SS) were very likely to belong to the unimpaired SC cluster. Compared with patients in the impaired SC cluster, those in the very impaired SC cluster performed significantly worse in lie scenes (TASIT-LI
- Published
- 2016
34. Pressure-Temperature-Deformation-Time constraints on the South Tibetan Detachment System along the Alaknanda–Dhauli Ganga valleys, Garhwal Himalaya (N India)
- Author
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Iaccarino S., Montomoli C., Carosi R., Montemagni C., Massonne H. -J., Jain A. K., Visonà D., Iaccarino, S, Montomoli, C, Carosi, R, Montemagni, C, Massonne, H, Jain, A, and Visonà, D
- Subjects
GEO/03 - GEOLOGIA STRUTTURALE ,Himalaya metamorphism, in situ geochronology, South Tibetan Detachment System - Published
- 2016
35. Pressure-Temperature-Deformation-Time Constraints on the South Tibetan Detachment System in the Garhwal Himalaya (NW India)
- Author
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Iaccarino S.[1, Montomoli C.[1, Carosi R.[2], Montemagni C.[4], Massonne H.-J.[5], Langone A.[6], Jain A. K.[7], and Visonà D.[8]
- Subjects
P-T-D-t path ,Himalaya ,Garhwal geology ,monazite geochronology ,South Tibetan Detachment System ,low-angle normal faults - Abstract
A peculiar feature of the Himalaya is the occurrence of a system of low-angle normal faults and shear zones, the South Tibetan Detachment System (STDS), at the mountain crests. The STDS was active during synconvergent tectonics. We describe the STDS-related sheared rocks along the Dhauli Ganga valley, in the Garhwal Himalaya (NW India), where the Malari granite, reported as an undeformed igneous body crosscutting the STDS, occurs. A detailed multidisciplinary study, integrating field-based, microstructural, petrographic, and geochronological analyses, was carried out on rocks along this valley. We demonstrate how the noncoaxial ductile portion of the STDS affected the upper part of the Greater Himalaya Sequence migmatite, which experienced peak pressure (P)-temperature (T) conditions of 0.9-1.1GPa and 750 degrees C at 24Ma. This migmatite has been reworked structurally upward leading to the formation of high-T sillimanite-bearing mylonites. Further upward, medium-T shearing deformed the Malari granite and leucogranite dykes, forming medium-T mylonites. Ductile shearing was temporally constrained, based on new in situ monazite datings and previously published Ar-Ar geochronology, between similar to 20 and 15Ma. We demonstrate that a preserved ductile to brittle spatial and temporal transition of the STDS deformation exists, with the brittle features overprinting ductile ones. Our data shed new light on the geological evolution of the STDS in the NW Himalaya with implications for the relationship and relative timing of partial melting, granite emplacement, and deformation along low-angle normal faults.
- Published
- 2017
36. The influence of illness-related variables, personal resources and context-related factors on real-life functioning of people with schizophrenia
- Author
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Galderisi, S, Rossi, A, Rocca, P, Bertolino, A, Mucci, A, Bucci, P, Rucci, P, Gibertoni, D, Aguglia, E, Amore, M, Bellomo, A, Biondi, M, Brugnoli, R, Dell'Osso, L, De Ronchi, D, Di Emidio, G, Di Giannantonio, M, Fagiolini, A, Marchesi, C, Monteleone, P, Oldani, L, Pinna, G, S, Pinna, F, Roncone, R, Sacchetti, E, Santonastaso, P, Siracusano, A, Vita, A, Zeppegno, P, Maj, M, Chieffi, M, De Simone, S, De Riso, F, Giugliano, R, Piegari, G, Vignapiano, A, Caforio, G, Mancini, M, Colagiorgio, L, Porcelli, S, Salfi, R, Bianchini, O, Galluzzo, A, Barlati, S, Carpiniello, B, Fatteri, F, Di Santa Sofia, S, Cannavò, D, Minutolo, G, Signorelli, M, Martinotti, G, Di Iorio, G, Acciavatti, T, Pallanti, S, Faravelli, C, Altamura, M, Stella, E, Marasco, D, Calcagno, P, Respino, M, Marozzi, V, Riccardi, I, Collazzoni, A, Stratta, P, Giusti, L, Ussorio, D, Delauretis, I, Serati, M, Caldiroli, A, Palazzo, C, Iasevoli, Fz, Gramaglia, C, Gili, S, Gattoni, E, Tenconi, E, Giannunzio, V, Monaco, F, De Panfilis, C, Camerlengo, A, Ossola, P, Landi, P, Rutigliano, G, Pergentini, I, Mauri, M, Di Fabio, F, Torti, C, Buzzanca, A, Comparelli, A, De Carolis, A, Corigliano, V, DI LORENZO, G, Niolu, C, Troisi, A, Corrivetti, Aa, G, Pinto, Diasco, Aa, F, Goracci, A, Bolognesi, S, Borghini, E, Montemagni, C, Frieri, T, Birindelli, N, Galderisi, S., Rossi, A., Rocca, P., Bertolino, A., Mucci, A., Bucci, P., Rucci, P., Gibertoni, D., Aguglia, E., Amore, M., Bellomo, A., Biondi, M., Brugnoli, R., Dell'Osso, L., De Ronchi, D., Di Emidio, G., Di Giannantonio, M., Fagiolini, A., Marchesi, C., Monteleone, P., Oldani, L., Pinna, F., Roncone, R., Sacchetti, E., Santonastaso, P., Siracusano, A., Vita, A., Zeppegno, P., Maj, M., Chieffi, M., De Simone, S., De Riso, F., Giugliano, R., Piegari, G., Vignapiano, A., Caforio, G., Mancini, M., Colagiorgio, L., Porcelli, S., Salfi, R., Bianchini, O., Galluzzo, A., Barlati, S., Carpiniello, B., Fatteri, F., Di Santa Sofia, S. L., Cannavo, D., Minutolo, G., Signorelli, M., Martinotti, G., Di Iorio, G., Acciavatti, T., Pallanti, S., Faravelli, C., Altamura, M., Stella, E., Marasco, D., Calcagno, P., Respino, M., Marozzi, V., Riccardi, I., Collazzoni, A., Stratta, P., Giusti, L., Ussorio, D., Delauretis, I., Serati, M., Caldiroli, A., Palazzo, C., Iasevoli, F., Gramaglia, C., Gili, S., Gattoni, E., Tenconi, E., Giannunzio, V., Monaco, F., De Panfilis, C., Camerlengo, A., Ossola, P., Landi, P., Rutigliano, G., Pergentini, I., Mauri, M., Di Fabio, F., Torti, C., Buzzanca, A., Comparelli, A., De Carolis, A., Corigliano, V., Di Lorenzo, G., Niolu, C., Troisi, A., Corrivetti, G., Pinto, G., Diasco, F., Goracci, A., Bolognesi, S., Borghini, E., Montemagni, C., Frieri, T., Birindelli, N., Galderisi, Silvana, Rossi, Alessandro, Rocca, Paola, Bertolino, Alessandro, Mucci, Armida, Bucci, Paola, Rucci, Paola, Gibertoni, Dino, Aguglia, Eugenio, Amore, Mario, Bellomo, Antonello, Biondi, Massimo, Brugnoli, Roberto, Dell'Osso, Liliana, De Ronchi, Diana, Di Emidio, Gabriella, Di Giannantonio, Massimo, Fagiolini, Andrea, Marchesi, Carlo, Monteleone, Palmiero, Oldani, Lucio, Pinna, Federica, Roncone, Rita, Sacchetti, Emilio, Santonastaso, Paolo, Siracusano, Alberto, Vita, Antonio, Zeppegno, Patrizia, Maj, Mario, Chieffi, Marcello, De Simone, Stefania, De Riso, Francesco, Giugliano, Rosa, Piegari, Giuseppe, Vignapiano, Annarita, Caforio, Grazia, Mancini, Marina, Colagiorgio, Lucia, Porcelli, Stefano, Salfi, Raffaele, Bianchini, Oriana, Galluzzo, Alessandro, Barlati, Stefano, Carpiniello, Bernardo, Fatteri, Francesca, Di Santa Sofia, Silvia Lostia, Cannavò, Dario, Minutolo, Giuseppe, Signorelli, Maria, Martinotti, Giovanni, Di Iorio, Giuseppe, Acciavatti, Tiziano, Pallanti, Stefano, Faravelli, Carlo, Altamura, Mario, Stella, Eleonora, Marasco, Daniele, Calcagno, Pietro, Respino, Matteo, Marozzi, Valentina, Riccardi, Ilaria, Collazzoni, Alberto, Stratta, Paolo, Giusti, Laura, Ussorio, Donatella, Delauretis, Ida, Serati, Marta, Caldiroli, Alice, Palazzo, Carlotta, Iasevoli, Felice, Gramaglia, Carla, Gili, Sabrina, Gattoni, Eleonora, Tenconi, Elena, Giannunzio, Valeria, Monaco, Francesco, De Panfilis, Chiara, Camerlengo, Annalisa, Ossola, Paolo, Landi, Paola, Rutigliano, Grazia, Pergentini, Irene, Mauri, Mauro, Di Fabio, Fabio, Torti, Chiara, Buzzanca, Antonino, Comparelli, Anna, De Carolis, Antonella, Corigliano, Valentina, Di Lorenzo, Giorgio, Niolu, Cinzia, Troisi, Alfonso, Corrivetti, Giulio, Pinto, Gaetano, Diasco, Ferdinando, Goracci, Arianna, Bolognesi, Simone, Borghini, Elisa, Montemagni, Cristiana, Frieri, Tiziana, and Birindelli, Nadia
- Subjects
medicine.medical_specialty ,media_common.quotation_subject ,neurocognition ,positive symptoms ,Context (language use) ,avolition ,Personal resource ,Social cognition ,Avolition ,Disorganization ,Engagement with mental health services ,Internalized stigma ,Neurocognition ,Personal resources ,Positive symptoms ,Real-life functioning ,Resilience ,Schizophrenia ,Psychiatry and Mental Health ,Psychiatric Mental Health ,medicine ,real-life functioning ,personal resources ,Psychiatry ,resilience ,Settore MED/25 - Psichiatria ,media_common ,business.industry ,Schizophrenia, avolition, disorganization, engagement with mental health services, internalized stigma, neurocognition, personal resources, positive symptoms, real-life functioning, resilience ,disorganization ,internalized stigma ,engagement with mental health services ,Social environment ,Research Reports ,medicine.disease ,Mental health ,Psychiatry and Mental health ,Psychological resilience ,Pshychiatric Mental Health ,medicine.symptom ,business ,Positive symptom ,Independent living ,Engagement with mental health service - Abstract
In people suffering from schizophrenia, major areas of everyday life are impaired, including independent living, productive activities and social relationships. Enhanced understanding of factors that hinder real-life functioning is vital for treatments to translate into more positive outcomes. The goal of the present study was to identify predictors of real-life functioning in people with schizophrenia, and to assess their relative contribution. Based on previous literature and clinical experience, several factors were selected and grouped into three categories: illness-related variables, personal resources and context-related factors. Some of these variables were never investigated before in relationship with real-life functioning. In 921 patients with schizophrenia living in the community, we found that variables relevant to the disease, personal resources and social context explain 53.8% of real-life functioning variance in a structural equation model. Neurocognition exhibited the strongest, though indirect, association with real-life functioning. Positive symptoms and disorganization, as well as avolition, proved to have significant direct and indirect effects, while depression had no significant association and poor emotional expression was only indirectly and weakly related to real-life functioning. Availability of a disability pension and access to social and family incentives also showed a significant direct association with functioning. Social cognition, functional capacity, resilience, internalized stigma and engagement with mental health services served as mediators. The observed complex associations among investigated predictors, mediators and real-life functioning strongly suggest that integrated and personalized programs should be provided as standard treatment to people with schizophrenia. In people suffering from schizophrenia, major areas of everyday life are impaired, including independent living, productive activities and social relationships. Enhanced understanding of factors that hinder real-life functioning is vital for treatments to translate into more positive outcomes. The goal of the present study was to identify predictors of real-life functioning in people with schizophrenia, and to assess their relative contribution. Based on previous literature and clinical experience, several factors were selected and grouped into three categories: illness-related variables, personal resources and context-related factors. Some of these variables were never investigated before in relationship with real-life functioning. In 921 patients with schizophrenia living in the community, we found that variables relevant to the disease, personal resources and social context explain 53.8% of real-life functioning variance in a structural equation model. Neurocognition exhibited the strongest, though indirect, association with real-life functioning. Positive symptoms and disorganization, as well as avolition, proved to have significant direct and indirect effects, while depression had no significant association and poor emotional expression was only indirectly and weakly related to real-life functioning. Availability of a disability pension and access to social and family incentives also showed a significant direct association with functioning. Social cognition, functional capacity, resilience, internalized stigma and engagement with mental health services served as mediators. The observed complex associations among investigated predictors, mediators and real-life functioning strongly suggest that integrated and personalized programs should be provided as standard treatment to people with schizophrenia.
- Published
- 2014
37. Pressure-Temperature-Deformation-Time Constraints on the South Tibetan Detachment System in the Garhwal Himalaya (NW India)
- Author
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Iaccarino, S., primary, Montomoli, C., additional, Carosi, R., additional, Montemagni, C., additional, Massonne, H.-J., additional, Langone, A., additional, Jain, A. K., additional, and Visonà, D., additional
- Published
- 2017
- Full Text
- View/download PDF
38. The Specific Level of Functioning Scale: construct validity, internal consistency and factor structure in a large Italian sample of people with schizophrenia living in the community
- Author
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Mucci, A, Rucci, P, Rocca, P, Bucci, P, Gibertoni, D, Merlotti, E, Galderisi, S, Maj, M, Chieffi, M, Luciano, M, Piegari, G, Plaitano, E, Sampogna, G, Bertolino, A, Salfi, R, Gheda, L, Pinna, F, Signorelli, M, Acciavatti, T, Faravelli, C, Pallanti, S, Altamura, M, Calcagno, P, Emidio, Gd, Roncone, Rita, Oldani, L, Bartolomeis, Ad, Gramaglia, C, Tenconi, E, Marchesi, C, Cargioli, C, Dell'Osso, L, Fabio, Fd, Girardi, P, Lorenzo, Gd, Monteleone, P, Bolognesi, S, Montemagni, C., Mucci, A, Rucci, P, Rocca, P, Bucci, P, Gibertoni, D, Merlotti, E, Galderisi, S, Maj, M, Chieffi, M, Luciano, M, Piegari, G, Plaitano, E, Sampogna, G, Bertolino, A, Salfi, R, Gheda, L, Pinna, F, Signorelli, M, Acciavatti, T, Faravelli, C, Pallanti, S, Altamura, M, Calcagno, P, Di Emidio, G, Roncone, R, Oldani, L, De Bartolomeis, A, Gramaglia, C, Tenconi, E, Marchesi, C, Cargioli, C, Dell'Osso, L, Di Fabio, F, Girardi, P, Di Lorenzo, G, Monteleone, P, Bolognesi, S, Montemagni, C., Armida Mucci, Paola Rucci, Paola Rocca, Paola Bucci, Dino Gibertoni, Eleonora Merlotti, Silvana Galderisi, Mario Maj, and Italian Network for Research on Psychoses
- Subjects
Factor structure ,Personal and Social Performance Scale ,Real-life functioning ,Schizophrenia ,Specific Level of Functioning Scale ,Validation ,Adult ,Female ,Humans ,Italy ,Male ,Middle Aged ,Personality ,Reproducibility of Results ,Statistics as Topic ,Activities of Daily Living ,Residence Characteristics ,Schizophrenic Psychology ,Social Behavior ,Biological Psychiatry ,Psychiatry and Mental Health ,Activities of daily living ,media_common.quotation_subject ,Reproducibility of Result ,Developmental psychology ,Goodness of fit ,Settore MED/25 - Psichiatria ,media_common ,Medicine (all) ,Construct validity ,Variance (accounting) ,Confirmatory factor analysis ,Psychiatry and Mental health ,Residence Characteristic ,Scale (social sciences) ,Principal component analysis ,Psychology ,Factor structure, Personal and Social Performance Scale, Real-life functioning, Schizophrenia, Specific Level of Functioning Scale, Validation ,Human ,Clinical psychology - Abstract
Background The study aimed to assess the construct validity, internal consistency and factor structure of the Specific Levels of Functioning Scale (SLOF), a multidimensional instrument assessing real life functioning. Methods The study was carried out in 895 Italian people with schizophrenia, all living in the community and attending the outpatient units of 26 university psychiatric clinics and/or community mental health departments. The construct validity of the SLOF was analyzed by means of the multitrait–multimethod approach, using the Personal and Social Performance (PSP) Scale as the gold standard. The factor structure of the SLOF was examined using both an exploratory principal component analysis and a confirmatory factor analysis. Results The six factors identified using exploratory principal component analysis explained 57.1% of the item variance. The examination of the multitrait–multimethod matrix revealed that the SLOF factors had high correlations with PSP factors measuring the same constructs and low correlations with PSP factors measuring different constructs. The confirmatory factor analysis (CFA) corroborated the 6-factor structure reported in the original validation study. Loadings were all significant and ranged from a minimum of 0.299 to a maximum of 0.803. The CFA model was adequately powered and had satisfactory goodness of fit indices (comparative fit index = 0.927, Tucker–Lewis index = 0.920 and root mean square error of approximation = 0.047, 95% CI 0.045–0.049). Conclusion The present study confirms, in a large sample of Italian people with schizophrenia living in the community, that the SLOF is a reliable and valid instrument for the assessment of social functioning. It has good construct validity and internal consistency, and a well-defined factor structure.
- Published
- 2013
39. Antipsicotici a rilascio prolungato nel trattamento della schizofrenia: una revisione della letteratura
- Author
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Graffino, M, Montemagni, C, Mingrone, C, and Rocca, Paola
- Published
- 2014
40. Correlazioni tra risposta soggettiva al trattamento antipsicotico, variabili cliniche e funzioni cognitive in schizofrenia
- Author
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Mongini, T., Crivelli, B., Marino, F., Mingrone, C., Montemagni, C., and Rocca, Paola
- Published
- 2007
41. Predittori di interruzione del trattamento in un servizio ambulatoriale di psichiatria. Predictors of drop-out in outpatient mental health care
- Author
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Rocca, Paola, DE LEO, Concetta, Giugiario, M., Marino, F., Mingrone, C., Mongini, T., Montemagni, C., and Pulvirenti, L.
- Published
- 2007
42. Correlazioni tra sintomi di base, psicopatologia e funzioni cognitive nella schizofrenia
- Author
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Montemagni, C., Castagna, F., Giugiario, M., Mingrone, C., Mongini, T., and Rocca, Paola
- Published
- 2007
43. Disturbi psichici nel post-partum
- Author
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Rocca, Paola, Montemagni, C, and Giugiario, M.
- Published
- 2006
44. Caratteristiche cognitive in soggetti schizofrenici paranoidi e non paranoidi
- Author
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Marchiaro, L, Marino, F, Montemagni, C, Scalese, M, Rasetti, R, and Rocca, Paola
- Published
- 2005
45. I modelli clinici sono diversi quando si lavora nel giudiziario?
- Author
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Bogetto, Filippo, Rocca, Paola, Calvarese, P, Montemagni, C, and Perrone, D.
- Published
- 2005
46. Studio retrospettivo di comparazione fra il trattamento con depot o con antipsicotici atipici in pazienti affetti da schizofrenia
- Author
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Marchiaro, L, Le Noci, F, Longo, P, Montemagni, C, Rigazzi, C, Rocca, Paola, and Bogetto, Filippo
- Published
- 2004
47. Il trattamento farmacologico del DPB
- Author
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Marchiaro, L, Marino, F, Montemagni, C, Rivoira, E, Rocca, Paola, and Bogetto, Filippo
- Published
- 2004
48. Clinical outcome and length of stay in an Italian Psychiatric Emergency Service
- Author
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Frieri, T., primary, Montemagni, C., additional, Rocca, G., additional, Rocca, P., additional, and Villari, V., additional
- Published
- 2012
- Full Text
- View/download PDF
49. Outcome and length of stay in psychiatric hospitalization, the experience of the University Clinic of Turin
- Author
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Rocca, Paola, primary, Mingrone, C., additional, Mongini, T., additional, Montemagni, C., additional, Pulvirenti, L., additional, Rocca, G., additional, and Bogetto, F., additional
- Published
- 2009
- Full Text
- View/download PDF
50. Quality of life in schizophrenia: Association with global functioning, symptomatology and neurocognition
- Author
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Giugiario, M., primary, Montemagni, C., additional, Crivelli, B., additional, and Rocca, P., additional
- Published
- 2008
- Full Text
- View/download PDF
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