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Additional file 1: Supplementary Table S1. Baseline characteristics of the 101 patients included in the study by baseline TNFi treatment status and radiographic progression. Supplementary Table S2. Baseline characteristics of the 101 patients included in the study by radiographic progression. Supplementary Table S3. Baseline characteristics of the 156 REGISPONSERBIO patients not included in the study. Supplementary Table S4. Comparison of baseline characteristics at first visit between patients included (101) and not included (156) in the study. Supplementary Table S5. Inter-observer reliability. Supplementary Figure S1 Blat and Altman Pot, inter-reader reliability. Supplementary Figure S2. Boxplot of the ASDAS values averaged across all time points in patients under long-term TNFi treatment. Supplementary Figure S3. Association between disease activity measured by BASDAI (a) and CRP(b) every 6 months with radiographic progression defined as an increase in the mSASSS score at ���2 points in patients unter TNFi treatment during a follow-up period of three years. Bold dots and intervals represent means and +/- their corresponding standard errors provided a the mixed-effects linear model (no other covariates included).