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Many studies have reported that heavy substance use is associated with impaired response inhibition. Studies typically focused on associations with a single substance, while polysubstance use is common. Further, most studies compared heavy users with light/non-users, though substance use occurs along a continuum. The current mega-analysis accounted for these issues by aggregating individual data from 43 studies (3610 adult participants) that used the Go/No-Go (GNG) or Stop-signal task (SST) to assess inhibition among mostly "recreational" substance users (i.e., the rate of substance use disorders was low). Main and interaction effects of substance use, demographics, and task-characteristics were entered in a linear mixed model. Contrary to many studies and reviews in the field, we found that only lifetime cannabis use was associated with impaired response inhibition in the SST. An interaction effect was also observed: the relationship between tobacco use and response inhibition (in the SST) differed between cannabis users and non-users, with a negative association between tobacco use and inhibition in the cannabis non-users. In addition, participants' age, education level, and some task characteristics influenced inhibition outcomes. Overall, we found limited support for impaired inhibition among substance users when controlling for demographics and task-characteristics.

Purpose: Stigma reduction is an important public health challenge because of the large morbidity and mortality associated with some forms of substance use. Extreme stigma can lead to dehumanisation of target groups, who are ascribed with lesser humanity. The authors examined whether there was blatant and subtle dehumanisation of people who use heroin, and if these were associated with levels of support for non-discriminatory drug policy. Design/methodology/approach: A cross-sectional online study using a UK convenience sample (n = 307 [75.2% female, mean age 28.6 ± 12.2 years]) was conducted. Participants completed assessments of blatant (Ascent of Humans [AoH] scale) and subtle (an emotion attribution task) dehumanisation and a bespoke measure assessing support for non-discriminatory drug policies. Other measures controlled for stigma towards people who use drugs (PWUD) and moral disgust. Findings: There was greater blatant dehumanisation of people who used heroin compared to the general population and other potentially stigmatised reference groups, including people who use cannabis. The authors also found evidence of subtle dehumanisation, and people who used heroin were rated as being less likely to feel uniquely human emotions, less likely to feel positive emotions and more likely to feel negative emotions. Blatant dehumanisation was associated with significantly lower probability of support for non-discriminatory drug policy. Social implications: Dehumanisation may present significant challenges for stigma reduction initiatives and in fostering public support for drug policy and treatment. Denial of the humanity of this group could be used to justify discriminatory policies or relative deprioritisation of support services in funding decisions. Activities that seek to "rehumanise" PWUD, including social inclusion, and encouraging compassionate media representations that portray the lived experiences of substance use may be useful areas of future work. Originality/value: This is the first study to investigate blatant and subtle dehumanisation of people who use heroin, and how this relates to public support for drug policy.

There has been recent UK media attention on the global impact of the cocaine trade and the morality of personal use of cocaine powder. In this study we investigated whether people who use cocaine engage in moral disengagement (MD) strategies to reduce anticipated guilt associated with use. Participants read text describing the impact of the global cocaine market on others and completed a range of measures including assessments of substance use, MD, anticipated guilt, internalised moral identity, and empathy. We hypothesised that cocaine-related MD would positively predict cocaine use, and this would be partly mediated by anticipated guilt. Complete data were obtained from 254 participants through an anonymous cross-sectional survey (59.8% Female; mean age 30.8 ± 12.6 years). Our hypotheses were supported; (i) MD predicted cocaine use positively and anticipated guilt negatively; (ii) anticipated guilt negatively predicted cocaine use; anticipated guilt partially mediated the relationship between MD and cocaine use. People who use powder cocaine may use MD to reduce the anticipated guilt associated with knowledge of the harms associated with the drugs trade. Campaigns that focus on the morality of cocaine use or ethical choices may therefore have limited impact unless MD is challenged as part of these campaigns. [ABSTRACT FROM AUTHOR]

Recent research suggests that not only does the use of recreational drugs impact on working memory functioning, but more 'everyday' aspects of memory (e.g. remembering to do something in the future) are also affected. Forty-three ecstasy-polydrug users and 51 non-ecstasy users were recruited from a university population. Each participant completed the Cognitive Failures Questionnaire (CFQ) and Everyday Memory Questionnaire (EMQ). Of these, 28 ecstasy-polydrug users and 35 non-ecstasy users completed the Prospective Memory Questionnaire (PMQ). In addition, an objective measure of cognitive failures (the CFQ-for-others) was completed by friends of participants. With the exception of the CFQ-forothers, in each regression equation, cannabis emerged as the only significant predictor of everyday and prospective memory deficits. Significant correlations were found between the different indicators of everyday memory and various measures of illicit drug use. Cannabis featured prominently in this respect. The present study provides further support for cannabis related deficits in aspects of everyday memory functioning. Ecstasy may also be associated with cognitive slips, but not to the same extent as cannabis. Keywords ecstasy, MDMA, cannabis, everyday memory, prospective memory, failure, Introduction With millions of individuals using the recreational drug ecstasy worldwide, the increasing amount of evidence reporting adverse effects of the drug is of major concern. Research suggests that ecstasy [...]