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Your search keyword '"Moon, Uk Yeol"' showing total 23 results
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23 results on '"Moon, Uk Yeol"'

2. Anticancer Effect of Verteporfin on Non-Small Cell Lung Cancer via Gradual Reduction of ANO1 Protein Levels

Author

Jeong, Sung Baek, primary, Das, Raju, additional, Kim, Dong-hyun, additional, Lee, Sion, additional, Oh, Hye In, additional, Jo, Sungwoo, additional, Kim, Jeongdong, additional, Park, SeonJu, additional, Moon, Uk Yeol, additional, Kwon, Oh-bin, additional, Namkung, Wan, additional, Lee, Sungwoo, additional, Cho, Byoung Chul, additional, Woo, Joohan, additional, and Seo, Yohan, additional

Published
2024
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3. ANO1-downregulation induced by schisandrathera D: a novel therapeutic target for the treatment of prostate and oral cancers

Author

Park, SeonJu, primary, Das, Raju, additional, Nhiem, Nguyen Xuan, additional, Jeong, Sung Baek, additional, Kim, Minuk, additional, Kim, Dongguk, additional, Oh, Hye In, additional, Cho, Su-Hyeon, additional, Kwon, Oh-Bin, additional, Choi, Jae-Hyeog, additional, Park, Chul Soon, additional, Kim, Song-Rae, additional, Moon, Uk Yeol, additional, Cha, Boksik, additional, Choi, Dong Kyu, additional, Lee, Sungwoo, additional, Namkung, Wan, additional, Woo, Joohan, additional, and Seo, Yohan, additional

Published
2023
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7. Multimodal Analysis of STRADA Function in Brain Development

Author

Dang, Louis T., primary, Glanowska, Katarzyna M., additional, Iffland II, Philip H., additional, Barnes, Allan E., additional, Baybis, Marianna, additional, Liu, Yu, additional, Patino, Gustavo, additional, Vaid, Shivanshi, additional, Streicher, Alexandra M., additional, Parker, Whitney E., additional, Kim, Seonhee, additional, Moon, Uk Yeol, additional, Henry, Frederick E., additional, Murphy, Geoffrey G., additional, Sutton, Michael, additional, Parent, Jack M., additional, and Crino, Peter B., additional

Published
2020
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20. Prostaglandin E2 Induces MUC8 Gene Expression via a Mechanism Involving ERK MAPK/RSK1/cAMP Response Element Binding Protein Activation in Human Airway Epithelial Cells

Author

Cho, Kyou-Nam, primary, Choi, Jae Young, additional, Kim, Chang-Hoon, additional, Baek, Seung Joon, additional, Chung, Kwang Chul, additional, Moon, Uk Yeol, additional, Kim, Kyung-Su, additional, Lee, Won-Jae, additional, Koo, Ja Seok, additional, and Yoon, Joo-Heon, additional

Published
2005
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22. Dexamethasone increases fluid absorption via Na+/H+ exchanger (NHE) 3 activation in normal human middle ear epithelial cells

Author

Choi, Jae Young, Kim, Sang Yub, Son, Eun Jin, Kim, Jung Lim, Shin, Ji-Hyun, Song, Mee Hyun, Moon, Uk Yeol, and Yoon, Joo-Heon

Subjects
*EPITHELIAL cells, *MIDDLE ear, *OTITIS media, *EAR diseases
Abstract

Abstract: The proper homeostasis of the liquid lining the surface of the middle ear cavity is vitally important for maintaining a fluid-free middle ear cavity. Disruption of this homeostasis leads to fluid collection in the middle ear cavity and results in otitis media with effusion. We demonstrated the molecular and functional expression of the Na+/H+ exchanger (NHE)s in normal human middle ear epithelial (NHMEE) cells. We also evaluated the role of NHEs in fluid absorption and the effect of dexamethasone on NHE function and NHE-dependent fluid absorption in NHMEE cells. Western blot analysis was performed for NHE1, -2, and -3 in NHMEE cells. The fluid absorption rate was measured after liquid application on the luminal surface of the cells. Intracellular pH (pHi) was measured using the pH-sensitive fluorescent probe bis-(2-carboxyethyl)-5(6)-carboxyfluorescein (BCECF)-AM. NHE activity was determined as Na+-induced pHi recovery from an acid load achieved by luminal exposure to 40 mmol/l NH4Cl. NHE1, -2 and -3 were all expressed in the NHMEE cells. The pHi recovery rate was suppressed by inhibition of NHE2 and -3 with HOE694 at concentrations greater than 50 μM. Inhibition of NHE3 with 650 μM of HOE694 or S3226 significantly decreased the fluid absorption rate. Dexamethasone increased the Na+-induced pHi recovery rate which was reversed by the inhibition of NHE3 with 650 μM of HOE694. Dexamethasone treatment up-regulated NHE3 expression in a dose-dependent manner. The fluid absorption rate was increased by treatment with dexamethasone (10-7 M) and reversed by the inhibition of NHE3. In summary, we have shown that NHE3 are involved in the regulation of both pHi and fluid absorption on the luminal surface of NHMEE cells. Dexamethasone stimulates NHE3 expression and NHE3-dependent fluid absorption in NHMEE cells. These findings provide a new insight into mechanisms that regulate periciliary fluid and the therapeutic mechanisms behind steroid treatment of otitis media with effusion. [Copyright &y& Elsevier]

Published
2006
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23. The apical complex protein Pals1 is required to maintain cerebellar progenitor cells in a proliferative state.

Author

Park JY, Hughes LJ, Moon UY, Park R, Kim SB, Tran K, Lee JS, Cho SH, and Kim S

Subjects
Animals, Cell Cycle genetics, Cerebellum cytology, Gene Expression Regulation, Developmental, Hedgehog Proteins metabolism, Membrane Proteins genetics, Mice, Mice, Knockout, Neuroglia cytology, Nucleoside-Phosphate Kinase genetics, Organogenesis genetics, Receptors, G-Protein-Coupled metabolism, Signal Transduction genetics, Smoothened Receptor, Cell Proliferation genetics, Cerebellum embryology, Membrane Proteins metabolism, Neurogenesis physiology, Nucleoside-Phosphate Kinase metabolism, Stem Cells cytology
Abstract

Through their biased localization and function within the cell, polarity complex proteins are necessary to establish the cellular asymmetry required for tissue organization. Well-characterized germinal zones, mitogenic signals and cell types make the cerebellum an excellent model for addressing the crucial function of polarity complex proteins in the generation and organization of neural tissues. Deletion of the apical polarity complex protein Pals1 in the developing cerebellum results in a remarkably undersized cerebellum with disrupted layers in poorly formed folia and strikingly reduced granule cell production. We demonstrate that Pals1 is not only essential for cerebellum organogenesis, but also for preventing premature differentiation and thus maintaining progenitor pools in cerebellar germinal zones, including cerebellar granule neuron precursors in the external granule layer. In the Pals1 mouse mutants, the expression of genes that regulate the cell cycle was diminished, correlating with the loss of the proliferating cell population of germinal zones. Furthermore, enhanced Shh signaling through activated Smo cannot overcome impaired cerebellar cell generation, arguing for an epistatic role of Pals1 in proliferation capacity. Our study identifies Pals1 as a novel intrinsic factor that regulates the generation of cerebellar cells and Pals1 deficiency as a potential inhibitor of overactive mitogenic signaling., (© 2016. Published by The Company of Biologists Ltd.)

Published
2016
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