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Multisystem inflammatory syndrome in children (MIS-C) is a rare but life-threatening hyperinflammatory condition induced by infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that causes pediatric COVID-19 (pCOVID-19). The relationship of the systemic tissue injury to the pathophysiology of MIS-C is poorly defined. We leveraged the high sensitivity of epigenomics analyses of plasma cell-free DNA (cfDNA) and plasma cytokine measurements to identify the spectrum of tissue injury and glean mechanistic insights. Compared with pediatric healthy controls (pHCs) and patients with pCOVID-19, patients with MIS-C had higher levels of cfDNA primarily derived from innate immune cells, megakaryocyte-erythroid precursor cells, and nonhematopoietic tissues such as hepatocytes, cardiac myocytes, and kidney cells. Nonhematopoietic tissue cfDNA levels demonstrated significant interindividual variability, consistent with the heterogenous clinical presentation of MIS-C. In contrast, adaptive immune cell–derived cfDNA levels were comparable in MIS-C and pCOVID-19 patients. Indeed, the cfDNA of innate immune cells in patients with MIS-C correlated with the levels of innate immune inflammatory cytokines and nonhematopoietic tissue–derived cfDNA, suggesting a primarily innate immunity–mediated response to account for the multisystem pathology. These data provide insight into the pathogenesis of MIS-C and support the value of cfDNA as a sensitive biomarker to map tissue injury in MIS-C and likely other multiorgan inflammatory conditions.

This study is concerned with the development of multi-input multi-output control algorithms for the active vibration suppression of structures using accelerometer signals and force-type actuators. The concept of the single-input single-output virtual tuned mass damper control algorithm developed in the previous study was extended to cope with multiple natural modes of structure equipped with a limited number of sensors and actuators. Two control algorithms were developed based on the assumption of collocated control. One is the decentralized virtual tuned mass damper control that produces the actuator signal using only the accelerometer signal of that actuator position. The other is the centralized virtual tuned mass damper control that is designed in modal-space, and produces the modal control force using the modal coordinate. Both the theoretical and experimental results show that the proposed control algorithms are effective in suppressing multiple natural modes with a lesser number of sensors and actuators. However, the decentralized virtual tuned mass damper control can be designed and implemented more easily than the centralized virtual tuned mass damper control.

The membrane-type air spring can be used to suppress lateral vibration of a vibration isolation table. However, compared to voice coil actuators, pneumatic actuators are difficult to use for precise vibration control, because servo valves have nonlinear dynamic characteristics. Therefore, actuators, such as voice coil actuators, can be placed in parallel with air springs, allowing force-type actuators to provide additional force to the system. These actuators generate force. In the case of a ball-screw mechanism device or a linear servomotor, it is an actuator that generates displacement. These actuators are represented as serial active systems. Serial active systems are structurally simpler than parallel active systems. However, there are very few studies on vibration isolation systems using serial active systems compared to parallel active systems. As the two are different types of systems, a new control algorithm suitable for the serial active system is needed. This study proposes a system in which an actuator capable of accurately controlling displacement is connected in series with a support spring-damper. A new active vibration control algorithm for the proposed control system is also developed, which is termed the position input and position output. The proposed control algorithm uses the displacement of the system as an input and outputs the desired displacement of the actuator installed in series with the damper and spring. The proposed control algorithm increases the damping at the target frequency and reduces the response of the system. Numerical studies and experiments were conducted on the single-degree-of-freedom and multi-degree-of-freedom systems. The results show the efficacy of the proposed control system and the novel control algorithm for the vibration suppression of the lateral vibration of a vibration isolation table.

In this study, an active mass damper that could track desired displacement was considered as a controller to suppress vibrations of a plate. Multi-input multi-output modal-space negative acceleration feedback control algorithm and decentralized multi-input multi-output negative acceleration feedback control algorithm were proposed and their stability conditions were checked theoretically. Stability conditions for both controllers are static, and they can effectively increase the damping of target mode without causing instability in low-frequency region. It was proved theoretically that both the multi-input multi-output modal-space negative acceleration feedback control and the decentralized multi-input multi-output negative acceleration feedback control can suppress vibrations of a continuous system such as a plate.

Various diets and food components have been implicated as one of the environmental factors associated with inflammatory bowel disease (IBD). Patients are often recommended nutritional guidelines to manage disease symptoms. However, the current food consumption pattern of US adults with IBD that are nationally representative is unclear. A secondary analysis of National Health Interview Survey 2015 was performed to characterize the estimated US adults with IBD and their food intake and consumption frequency using bivariate and multivariate logistic regression. Fries were consumed by a greater number of people with IBD. IBD population drank less 100% fruit juice and ate more cheese and cookies than non-IBD population. Intake of fries (OR 1.60, 95% CI 1.14-2.25) and sports and energy drinks (OR 1.46, 95% CI 1.07-1.97) and more frequent drinking of regular soda were significantly associated with the likelihood of having been told one have IBD, while popcorn (OR 0.73, 95% CI 0.548-0.971) and milk (OR 0.70, 95% CI 0.497-0.998) were associated with smaller odds, adjusting for covariates. Foods typically labeled as junk food were positively associated with IBD. Nonetheless, of the assessed 26 foods, we found eating patterns between IBD and non-IBD population to be mostly analogous. It is unclear whether the results reflect potential change in food intake in IBD population long before the survey interview. Understanding the role of food intake in IBD risk/prevalence would benefit from identifying other environmental factors (i.e. food desert), food processing (i.e. frying), and potential bioactive food components that can induce intestinal inflammation that can increase the individual's susceptibility to IBD.

Background & Aims: The human intestinal peptide transporter 1 (hPepT1), is expressed in the small intestine at low levels in the healthy colon and up-regulated during inflammatory bowel disease. hPepT1 plays a role in mouse colitis and human studies have shown that chronic intestinal inflammation leads to colorectal cancer (colitis-associated cancer; CAC). Hence, we assessed here the role of PepT1 in CAC. Methods: Mice with hPepT1 overexpression in intestinal epithelial cells (transgenic [TG]) or PepT1 (PepT1-knockout [KO]) deletion were used and CAC was induced by azoxymethane/dextran sodium sulfate. Results: TG mice had larger tumor sizes, increased tumor burdens, and increased intestinal inflammation compared with wild-type (WT) mice. Conversely, tumor number and size and intestinal inflammation were decreased significantly in PepT1-KO mice. Proliferating crypt cells were increased in TG mice and decreased in PepT1-KO mice. Analysis of human colonic biopsy specimens showed increased expression of PepT1 in patients with colorectal cancer, suggesting that PepT1 might be targeted for the treatment of CAC. The use of an anti-inflammatory tripeptide Lys-Pro-Val (KPV) transported by PepT1 was able to prevent carcinogenesis in WT mice. When administered to PepT1-KO mice, KPV did not trigger any of the inhibitory effect on tumorigenesis observed in WT mice. Conclusions: The observations that PepT1 was highly expressed in human colorectal tumor and that its overexpression and deletion in mice increased and decreased colitis-associated tumorigenesis, respectively, suggest that PepT1 is a potential therapeutic target for the treatment of colitis-associated tumorigenesis. Keywords: Colitis-Associated Cancer, Intestinal Inflammation, PepT1, KPV Peptide

Numerical and analytical investigation of the effects of thermal radiation and viscous heating on a convective flow of a non-Newtonian, incompressible fluid in an axisymmetric stretching sheet with constant temperature wall is performed. The power law model of the blood is used for the non-Newtonian model of the fluid and the Rosseland model for the thermal radiative heat transfer in an absorbing medium and viscous heating are considered as the heat sources. The non-dimensional governing equations are transformed to similarity form and solved numerically. A parameter study on entropy generation in medium is presented based on the Second Law of Thermodynamics by considering various parameters such as the thermal radiation parameter, the Brinkman number, Prandtl number, Eckert number.

Here we report on the existence and functionality of the immune checkpoint signal regulatory protein α (SIRPα) in NK cells and describe how it can be modulated for cell therapy. NK cell SIRPα is up-regulated upon IL-2 stimulation, interacts with target cell CD47 in a threshold-dependent manner, and counters other stimulatory signals, including IL-2, CD16, or NKG2D. Elevated expression of CD47 protected K562 tumor cells and mouse and human MHC class I-deficient target cells against SIRPα+ primary NK cells, but not against SIRPα- NKL or NK92 cells. SIRPα deficiency or antibody blockade increased the killing capacity of NK cells. Overexpression of rhesus monkey CD47 in human MHC-deficient cells prevented cytotoxicity by rhesus NK cells in a xenogeneic setting. The SIRPα-CD47 axis was found to be highly species specific. Together, the results demonstrate that disruption of the SIRPα-CD47 immune checkpoint may augment NK cell antitumor responses and that elevated expression of CD47 may prevent NK cell-mediated killing of allogeneic and xenogeneic tissues.

Temesgen E. Andargie, Katerina Roznik, Neelam Redekar, Tom Hill, Weiqiang Zhou, Zainab Apalara, Hyesik Kong, Oren Gordon, Rohan Meda, Woojin Park, Trevor S. Johnston, Yi Wang, Sheila Brady, Hongkai Ji, [...]

This paper advances scholarly debate on the contradictions of environmental risk management measures by analyzing the determinants of flood insurance coverage among a sample of 403 residents in New Orleans, a city undergoing rapid transformation due to post-Katrina rebuilding efforts and anthropogenic modifications of climate, hydrology, and ecology. The paper focuses on several predictors including subjective flood risk perception, trust in government officials, sociodemographic characteristics, and experience with flood damage. Using binary logistic regression, the results show that the likelihood of having flood insurance coverage is associated with past flood damage and socioeconomic status. Older people (over age 65) are more likely to have flood insurance than younger residents. Race, gender, trust, and perceived flood risk are not statistically significant predictors of flood insurance. We connect our findings to the paradoxes and conflictual dynamics of flood insurance, a major risk mitigation measure. As we point out, in flood-prone cities like New Orleans, flood insurance operates as a double whammy: uninsured or underinsured homes face pervasive risk of both flooding and rising insurance premiums under the conditions of global climate change.

Multisystem inflammatory syndrome in children (MIS-C) is a rare but life- threatening hyperinflammatory condition induced by infection with severe acute respiratory syndrome coronavirus 2 (SARS- CoV-2) that causes pediatric COVID-19 (pCOVID-19). The relationship of the systemic tissue injury to the pathophysiology of MIS-C is poorly defined. We leveraged the high sensitivity of epigenomics analyses of plasma cell-free DNA (cfDNA) and plasma cytokine measurements to identify the spectrum of tissue injury and glean mechanistic insights. Compared with pediatric healthy controls (pHCs) and patients with pCOVID-19, patients with MIS-C had higher levels of cfDNA primarily derived from innate immune cells, megakaryocyte-erythroid precursor cells, and nonhematopoietic tissues such as hepatocytes, cardiac myocytes, and kidney cells. Nonhematopoietic tissue cfDNA levels demonstrated significant interindividual variability, consistent with the heterogenous clinical presentation of MIS-C. In contrast, adaptive immune cell-derived cfDNA levels were comparable in MIS-C and pCOVID-19 patients. Indeed, the cfDNA of innate immune cells in patients with MIS-C correlated with the levels of innate immune inflammatory cytokines and nonhematopoietic tissue- derived cfDNA, suggesting a primarily innate immunity-mediated response to account for the multisystem pathology. These data provide insight into the pathogenesis of MIS-C and support the value of cfDNA as a sensitive biomarker to map tissue injury in MIS-C and likely other multiorgan inflammatory conditions., Introduction Multisystem inflammatory syndrome in children (MIS-C) is a rare yet life-threatening hyperinflammatory condition induced by infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) (1). MIS-C shares clinical features [...]

Objective: The purpose of the study was to investigate the differences between intimate partner violence (IPV) and parenting attitudes by race by comparing demographic, parenting, and IPV indicators for African American and White men. Method: The study employed a nonequivalent, control group design in a secondary analysis of 111 men. Results: Analyses indicated that (1) African American men had more children; (2) chi-square tests revealed no statistically significant differences between African American and Caucasian men with respect to IPV perpetration and parenting attitudes; and (3) a logistic regression model indicated that the number of children and a higher risk category for parenting attitudes were significant predictors of race group membership. Conclusion: These findings reveal that having more children is related to a higher level of stress on intimate partner relationships, and these stressors are not evenly distributed across racial groups. Batterer intervention programs should include parenting skills to help perpetrators better cope with such stresses.

In this article, we apply three theoretical frameworks, poststructural feminism, queer, and sociology of gender to the issue of intimate partner violence (IPV) in order to better account for heterosexual female perpetration and same-sex IPV. Although the traditional feminist paradigm-that assumes men use violence as an extension of patriarchy against their female victims-has been useful in explaining some instances of IPV, it does not adequately frame instances of heterosexual female perpetration and IPV in same-sex relationships. Therefore, in this article we seek to add to existing literature by re-theorizing IPV using poststructural feminism, queer, and sociology of gender perspectives, and their attendant understanding of power as dynamic, fluid, and relational and gender as both interactional and structural, in order to open up new ways of framing IPV and encourage new lines of empirical research resulting in better policy proscriptions and treatment interventions.