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2. Conduction system pacing in pediatric and congenital heart disease.

Author

Chubb, Henry, Mah, Douglas, Dubin, Anne, and Moore, Jeremy

Subjects
His bundle pacing (HBP), conduction system pacing, congenital heart disease, heart failure, left bundle area pacing, pacing induced cardiomyopathy, pediatric, transposition of the great arteries (TGA)
Abstract

Conduction system pacing (CSP) has evolved rapidly to become the pacing method of choice for many adults with structurally normal hearts. Studies in this population have repeatedly demonstrated superior hemodynamics and outcomes compared to conventional pacing with the recruitment of the native conduction system. Children and patients with congenital heart disease (CHD) are also likely to benefit from CSP but were excluded from original trials. However, very recent studies have begun to demonstrate the feasibility and efficacy of CSP in these patients, with growing evidence that some outcomes may be superior in comparison to conventional pacing techniques. Concerns regarding the technical challenges and long-term lead parameters of His Bundle Pacing (HBP) have been overcome to many extents with the development of Left Bundle Branch Area Pacing (LBBAP), and both techniques are likely to play an important role in pediatric and CHD pacing in the future. This review aims to assimilate the latest developments in CSP and its application in children and CHD patients.

Published
2023

3. Testing the ion-current model for flagellar length sensing and IFT regulation

Author

Ishikawa, Hiroaki, Moore, Jeremy, Diener, Dennis R, Delling, Markus, and Marshall, Wallace F

Subjects
Biological Sciences, Medical Physiology, Biomedical and Clinical Sciences, 1.1 Normal biological development and functioning, Underpinning research, Generic health relevance, Chlamydomonas reinhardtii, Biological Transport, Flagella, Cilia, Chlamydomonas, cilia, flagella, intraflagellar transport, calcium, cell biology, chlamydomonas reinhardtii, Biochemistry and Cell Biology, Biological sciences, Biomedical and clinical sciences, Health sciences
Abstract

Eukaryotic cilia and flagella are microtubule-based organelles whose relatively simple shape makes them ideal for investigating the fundamental question of organelle size regulation. Most of the flagellar materials are transported from the cell body via an active transport process called intraflagellar transport (IFT). The rate of IFT entry into flagella, known as IFT injection, has been shown to negatively correlate with flagellar length. However, it remains unknown how the cell measures the length of its flagella and controls IFT injection. One of the most-discussed theoretical models for length sensing to control IFT is the ion-current model, which posits that there is a uniform distribution of Ca2+ channels along the flagellum and that the Ca2+ current from the flagellum into the cell body increases linearly with flagellar length. In this model, the cell uses the Ca2+ current to negatively regulate IFT injection. The recent discovery that IFT entry into flagella is regulated by the phosphorylation of kinesin through a calcium-dependent protein kinase has provided further impetus for the ion-current model. To test this model, we measured and manipulated the levels of Ca2+ inside of Chlamydomonas flagella and quantified IFT injection. Although the concentration of Ca2+ inside of flagella was weakly correlated with the length of flagella, we found that IFT injection was reduced in calcium-deficient flagella, rather than increased as the model predicted, and that variation in IFT injection was uncorrelated with the occurrence of flagellar Ca2+ spikes. Thus, Ca2+ does not appear to function as a negative regulator of IFT injection, hence it cannot form the basis of a stable length control system.

Published
2023

4. Cardiac Resynchronization Therapy for Adult Patients With a Failing Systemic Right Ventricle: A Multicenter Study.

Author

Kharbanda, Rohit K, Moore, Jeremy P, Lloyd, Michael S, Galotti, Robert, Bogers, Ad JJC, Taverne, Yannick JHJ, Madhavan, Malini, McLeod, Christopher J, Dubin, Anne M, Mah, Douglas Y, Chang, Philip M, Kamp, Anna N, Nielsen, Jens C, Aydin, Alper, Tanel, Ronn E, Shah, Maully J, Pilcher, Thomas, Evertz, Reinder, Khairy, Paul, Tan, Reina B, Czosek, Richard J, Shivkumar, Kalyanam, and de Groot, Natasja MS

Subjects
Heart Ventricles, Humans, Transposition of Great Vessels, Treatment Outcome, Retrospective Studies, Adult, Middle Aged, Female, Male, Heart Failure, Cardiac Resynchronization Therapy, cardiac resynchronization therapy, congenital heart disease, heart failure, pacing, systemic right ventricle, Cardiovascular, Heart Disease, Cardiorespiratory Medicine and Haematology
Abstract

Background The objective of this international multicenter study was to investigate both early and late outcomes of cardiac resynchronization therapy (CRT) in patients with a systemic right ventricle (SRV) and to identify predictors for congestive heart failure readmissions and mortality. Methods and Results This retrospective international multicenter study included 13 centers. The study population comprised 80 adult patients with SRV (48.9% women) with a mean age of 45±14 (range, 18-77) years at initiation of CRT. Median follow-up time was 4.1 (25th-75th percentile, 1.3-8.3) years. Underlying congenital heart disease consisted of congenitally corrected transposition of the great arteries and dextro-transposition of the great arteries in 63 (78.8%) and 17 (21.3%) patients, respectively. CRT resulted in significant improvement in functional class (before CRT: III, 25th-75th percentile, II-III; after CRT: II, 25th-75th percentile, II-III; P=0.005) and QRS duration (before CRT: 176±27; after CRT: 150±24 milliseconds; P=0.003) in patients with pre-CRT ventricular pacing who underwent an upgrade to a CRT device (n=49). These improvements persisted during long-term follow-up with a marginal but significant increase in SRV function (before CRT; 30%, 25th-75th percentile, 25-35; after CRT: 31%, 25th-75th percentile, 21-38; P=0.049). In contrast, no beneficial change in the above-mentioned variables was observed in patients who underwent de novo CRT (n=31). A quarter of all patients were readmitted for heart failure during follow-up, and mortality at latest follow-up was 21.3%. Conclusions This international experience with CRT in patients with an SRV demonstrated that CRT in selected patients with SRV dysfunction and pacing-induced dyssynchrony yielded consistent improvement in QRS duration and New York Heart Association functional status, with a marginal increase in SRV function.

Published
2022

5. Patterns of Electrocardiographic Abnormalities in Children with Hypertrophic Cardiomyopathy

Author

Marshall, Mayme, Malik, Aneeq, Shah, Maully, Fish, Frank A., Etheridge, Susan P., Aziz, Peter F., Russell, Mark W., Tisma, Svjetlana, Pflaumer, Andreas, Sreeram, Narayanswami, Kubus, Peter, Law, Ian H., Kantoch, Michal J., Kertesz, Naomi J., Strieper, Margaret, Erickson, Christopher C., Moore, Jeremy P., Nakano, Stephanie J., Singh, Harinder R., Chang, Philip, Cohen, Mitchell, Fournier, Anne, Ilina, Maria V., Zimmermann, Frank, Horndasch, Michaela, Li, Walter, Batra, Anjan S., Liberman, Leonardo, Hamilton, Robert, Janson, Christopher M., Sanatani, Shubhayan, Zeltser, Ilana, McDaniel, George, Blaufox, Andrew D., Garnreiter, Jason M., and Balaji, Seshadri

Published
2023
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13. Electrophysiological Characteristics of Intra-Atrial Reentrant Tachycardia in Adult Congenital Heart Disease: Implications for Catheter Ablation.

Author

Kahle, Ann-Kathrin, Gallotti, Roberto, Alken, Fares-Alexander, Meyer, Christian, and Moore, Jeremy

Subjects
adult congenital heart disease, catheter ablation, conduction velocity, high‐density mapping, intra‐atrial reentrant tachycardia, Action Potentials, Adult, Cardiac Surgical Procedures, Catheter Ablation, Electrophysiologic Techniques, Cardiac, Female, Germany, Heart Defects, Congenital, Heart Rate, Humans, Los Angeles, Male, Middle Aged, Predictive Value of Tests, Retrospective Studies, Tachycardia, Supraventricular
Abstract

Background Ultra-high-density mapping enables detailed mechanistic analysis of atrial reentrant tachycardia but has yet to be used to assess circuit conduction velocity (CV) patterns in adults with congenital heart disease. Methods and Results Circuit pathways and central isthmus CVs were calculated from consecutive ultra-high-density isochronal maps at 2 tertiary centers over a 3-year period. Circuits using anatomic versus surgical obstacles were considered separately and pathway length 85% predicted isthmus block in all cases. Over >1 year of follow-up, arrhythmia-free survival was better for homogeneous CV patterns (90% versus 57%; P=0.04). Conclusions Ultra-high-density mapping-guided CV analysis distinguishes atrial reentrant patterns in adults with congenital heart disease with surgical obstacles producing slower and smaller circuits. Very slow central isthmus CV may be essential for atrial tachycardia maintenance in small circuits, and non-isthmus conduction time in tachycardia appears to be useful for rapid assessment of postablation conduction block.

Published
2021

15. Multicenter retrospective evaluation of magnetic resonance imaging in pediatric and congenital heart disease patients with cardiac implantable electronic devices

Author

Gakenheimer-Smith, Lindsey, Ou, Zhining, Kuang, Jinqiu, Moore, Jeremy P., Burrows, Austin, Kovach, Joshua, Dechert, Brynn, Beach, Cheyenne M., Ayers, Mark, Tan, Reina Bianca, Mostafavifar, Mina, Mah, Douglas Y., Conner, Tracy Marrs, Turpin, Susan, Avasarala, Kishor, Shah, Maully J., Webster, Gregory, Posey, Jessica, Etheridge, Susan P., Binka, Edem, Niu, Mary, Asaki, S. Yukiko, Lambert, Linda M., and Pilcher, Thomas A.

Published
2023
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17. Recurrent sustained atrial arrhythmias and thromboembolism in Fontan patients with total cavopulmonary connection.

Author

Egbe, Alexander, Miranda, William, Devara, Janaki, Shaik, Likhita, Iftikhar, Momina, Goda Sakr, Ahmed, John, Anitha, Cedars, Ari, Rodriguez, Fred, Moore, Jeremy, Russell, Matthew, Grewal, Jasmine, Ginde, Salil, Lubert, Adam, and Connolly, Heidi

Subjects
AAD, anti-arrhythmic drug therapy, Atrial arrhythmia, Fontan operation, TCPC, total cavopulmonary connection, Thromboembolic complication, Total cavopulmonary connection
Abstract

BACKGROUND: Total cavopulmonary connection (TCPC) is associated with a lower risk of incident atrial arrhythmias as compared to atriopulmonary Fontan, but the risk of recurrent atrial arrhythmias is unknown in this population. The purpose of this study was to determine the incidence and risk factors for recurrent atrial arrhythmias and thromboembolic complications in patients with TCPC. METHODS: This is a retrospective multicenter study conducted by the Alliance for Adult Research in Congenital Cardiology (AARCC), 2000-2018. The inclusion criteria were TCPC patients (age > 15 years) with prior history of atrial arrhythmia. RESULTS: A total of 103 patients (age 26 ± 7 years; male 58 [56%]) met inclusion criteria. The mean age at initial arrhythmia diagnosis was 13 ± 5 years, and atrial arrhythmias were classified as atrial flutter/tachycardia in 85 (83%) and atrial fibrillation in 18 (17%). The median duration of follow-up from the first episode of atrial arrhythmia was 14.9 (12.1-17.3) years, and during this period 64 (62%) patients had recurrent atrial arrhythmias (atrial flutter/tachycardia 51 [80%] and atrial fibrillation 13 [20%]) with annual incidence of 4.4%. Older age was a risk factor for arrhythmia recurrence while the use of a class III anti-arrhythmic drug was associated with a lower risk of recurrent arrhythmias. The incidence of thromboembolic complication was 0.6% per year, and the cumulative incidence was 4% and 7% at 5 and 10 years respectively from the time of first atrial arrhythmia diagnosis. There were no identifiable risk factors for thromboembolic complications in this cohort. CONCLUSIONS: Although TCPC provides superior flow dynamics and lower risk of incident atrial arrhythmias, there is a significant risk of recurrent arrhythmias among TCPC patients with a prior history of atrial arrhythmias. These patients may require more intensive arrhythmia surveillance as compared to other TCPC patients.

Published
2021

18. Rationale and Design of the Multicenter Catheter Ablation of Ventricular Tachycardia Before Transcatheter Pulmonary Valve Replacement in Repaired Tetralogy of Fallot Study

Author

Moore, Jeremy P., Aboulhosn, Jamil A., Zeppenfeld, Katja, Waldmann, Victor, Bessière, Francis, Blom, Nico A., Combes, Nicolas, Fish, Frank A., McLeod, Christopher J., Kanter, Ronald J., Tan, Weiyi, Patel, Nimesh, von Alvensleben, Johannes C., Kamp, Anna, Lloyd, Michael S., Anderson, Charles C., Tan, Reina B., Mariucci, Elisabetta, Levi, Daniel S., Salem, Morris, Shivkumar, Kalyanam, and Khairy, Paul

Published
2023
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21. Genotype Predicts Outcomes in Fetuses and Neonates With Severe Congenital Long QT Syndrome

Author

Moore, Jeremy P, Gallotti, Roberto G, Shannon, Kevin M, Bos, J Martijn, Sadeghi, Elham, Strasburger, Janette F, Wakai, Ronald T, Horigome, Hitoshi, Clur, Sally-Ann, Hill, Allison C, Shah, Maully J, Behere, Shashank, Sarquella-Brugada, Georgia, Czosek, Richard, Etheridge, Susan P, Fischbach, Peter, Kannankeril, Prince J, Motonaga, Kara, Landstrom, Andrew P, Williams, Matthew, Patel, Akash, Dagradi, Federica, Tan, Reina B, Stephenson, Elizabeth, Krishna, Mani Ram, Miyake, Christina Y, Lee, Michelle E, Sanatani, Shubhayan, Balaji, Seshadri, Young, Ming-Lon, Siddiqui, Saad, Schwartz, Peter J, Shivkumar, Kalyanam, and Ackerman, Michael J

Subjects
Genetics, Cardiovascular, Pediatric, Infant Mortality, Clinical Research, Heart Disease, Perinatal Period - Conditions Originating in Perinatal Period, Aftercare, Electrocardiography, Fetus, Genotype, Humans, Infant, Newborn, Long QT Syndrome, Patient Discharge, Retrospective Studies, atrioventricular block, cardiac sympathetic denervation, fetal arrhythmia, fetus, genetic testing, implantable cardioverter-defibrillator, long QT syndrome, magnetocardiography, sudden cardiac death, torsades de pointes, Cardiorespiratory Medicine and Haematology, Clinical Sciences
Abstract

ObjectivesThis study sought to determine the relationship between long QT syndrome (LQTS) subtype (LTQ1, LTQ2, LTQ3) and postnatal cardiac events (CEs).BackgroundLQTS presenting with 2:1 atrioventricular block or torsades de pointes in the fetus and/or neonate has been associated with risk for major CEs, but overall outcomes and predictors remain unknown.MethodsA retrospective study involving 25 international centers evaluated the course of fetuses/newborns diagnosed with congenital LQTS and either 2:1 atrioventricular block or torsades de pointes. The primary outcomes were age at first CE after dismissal from the newborn hospitalization and death and/or cardiac transplantation during follow-up. CE was defined as aborted cardiac arrest, appropriate shock from implantable cardioverter-defibrillator, or sudden cardiac death.ResultsA total of 84 fetuses and/or neonates were identified with LQTS (12 as LQT1, 35 as LQT2, 37 as LQT3). Median gestational age at delivery was 37 weeks (interquartile range: 35 to 39 weeks) and age at hospital discharge was 3 weeks (interquartile range: 2 to 5 weeks). Fetal demise occurred in 2 and pre-discharge death in 1. Over a median of 5.2 years, there were 1 LQT1, 3 LQT2, and 23 LQT3 CEs (13 aborted cardiac arrests, 5 sudden cardiac deaths, and 9 appropriate shocks). One patient with LQT1 and 11 patients with LQT3 died or received cardiac transplant during follow-up. The only multivariate predictor of post-discharge CEs was LQT3 status (LQT3 vs. LQT2: hazard ratio: 8.4; 95% confidence interval: 2.6 to 38.9; p

Published
2020

22. Determinants of Sudden Cardiac Death in Adult Patients With Eisenmenger Syndrome.

Author

Chiriac, Anca, Riley, David, Russell, Matthew, Moore, Jeremy, Padmanabhan, Deepak, Hodge, David, Spiegel, Matthew, Vargas, Emily, Phillips, Sabrina, Ammash, Naser, Madhavan, Malini, Asirvatham, Samuel, and McLeod, Christopher

Subjects
Eisenmenger syndrome, atrial fibrillation, cardiac arrhythmia, congenital heart disease, congestive heart failure, sudden cardiac death, Adult, Arrhythmias, Cardiac, Cause of Death, Death, Sudden, Cardiac, Eisenmenger Complex, Female, Florida, Humans, Los Angeles, Male, Middle Aged, Retrospective Studies, Risk Assessment, Risk Factors, Time Factors, Young Adult
Abstract

Background Patients with Eisenmenger syndrome are known to have a high incidence of sudden cardiac death (SCD), yet the underlying causes are not well understood. We sought to define the predictors of SCD in this population. Methods and Results A retrospective analysis of all patients with Eisenmenger syndrome from 2 large tertiary referral centers was performed. ECGs, prolonged ambulatory recordings, echocardiograms, and clinical histories were reviewed; and the cause of death was identified. A total of 246 patients (85 [34.6%] men) with a mean age of 37.3 (±14.2) years were followed up for a median of 7 years. Over the study period, 136 patients died, with 40 experiencing SCD and 74 experiencing cardiac death (sudden and nonsudden). Age, atrial fibrillation, prolonged QRS duration, complete heart block, right atrial enlargement, right bundle branch block, increased right atrial pressure, impaired biventricular function, and the presence of a pacemaker were associated with increased risk of SCD, whereas advanced pulmonary hypertension therapies were protective. Atrial fibrillation (11.45-fold increased risk; P

Published
2020

23. Atrial Standstill in the Pediatric Population: A Multi-Institution Collaboration

Author

Howard, Taylor S., Chiang, David Y., Ceresnak, Scott R., Ladouceur, Virginie Beausejour, Whitehill, Robert D., Czosek, Richard J., Knilans, Timothy K., Ahnfeldt, Agnethe M., Borresen, Malene Lando, Jaeggi, Edgar, Udupa, Sharmila, Gow, Robert, Moore, Jeremy P., Galloti, Roberto G., Mah, Doug Y., Kim, Jeffrey J., Valdes, Santiago O., Milewicz, Dianna M., and Miyake, Christina Y.

Published
2023
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25. Impact and Modifiers of Ventricular Pacing in Patients With Single Ventricle Circulation

Author

Chubb, Henry, Bulic, Anica, Mah, Douglas, Moore, Jeremy P., Janousek, Jan, Fumanelli, Jennifer, Asaki, S. Yukiko, Pflaumer, Andreas, Hill, Allison C., Escudero, Carolina, Kwok, Sit Yee, Mangat, Jasveer, Ochoa Nunez, Luis A., Balaji, Seshadri, Rosenthal, Eric, Regan, William, Horndasch, Michaela, Asakai, Hiroko, Tanel, Ronn, Czosek, Richard J., Young, Ming-Lon, Bradley, David J., Paul, Thomas, Fischbach, Peter, Malloy-Walton, Lindsey, McElhinney, Doff B., and Dubin, Anne M.

Published
2022
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33. Catheter Ablation for Atrial Fibrillation in Adult Congenital Heart Disease: An International Multicenter Registry Study

Author

Griffiths, Jack R., Nussinovitch, Udi, Liang, Jackson J., Sims, Richard, Yoneda, Zachary T., Bernstein, Hannah M., Viswanathan, Mohan N., Khairy, Paul, Srivatsa, Uma N., Frankel, David S., Marchlinski, Francis E., Sandhu, Amneet, Shoemaker, M. Benjamin, Mohanty, Sanghamitra, Burkhardt, John D., Natale, Andrea, Lakireddy, Dhanunjaya, De Groot, Natasja M.S., Gerstenfeld, Edward P., Moore, Jeremy P., Ávila, Pablo, Ernst, Sabine, and Nguyen, Duy T.

Published
2022
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34. Subcutaneous Implantable Cardioverter-Defibrillators in Pediatrics and Congenital Heart Disease: A Pediatric and Congenital Electrophysiology Society Multicenter Review

Author

von Alvensleben, Johannes C., Dechert, Brynn, Bradley, David J., Fish, Frank A., Moore, Jeremy P., Pilcher, Thomas A., Escudero, Carolina, Ceresnak, Scott R., Kwok, Sit Yee, Balaji, Seshadri, Aziz, Peter F., Papagiannis, John, Cortez, Daniel, Garnreiter, Jason, Kean, Adam, Schäfer, Michal, and Collins, Kathryn K.

Published
2020
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36. Loss of ventricular preexcitation during noninvasive testing does not exclude high-risk accessory pathways: A multicenter study of WPW in children

Author

Escudero, Carolina A., Ceresnak, Scott R., Collins, Kathryn K., Pass, Robert H., Aziz, Peter F., Blaufox, Andrew D., Ortega, Michel Cabrera, Cannon, Bryan C., Cohen, Mitchell I., Dechert, Brynn E., Dubin, Anne M., Motonaga, Kara S., Epstein, Michael R., Erickson, Christopher C., Fishberger, Steven B., Gates, Gregory J., Capone, Christine A., Nappo, Lynn, Kertesz, Naomi J., Kim, Jeffrey J., Valdes, Santiago O., Kubuš, Peter, Law, Ian H., Maldonado, Jennifer, Moore, Jeremy P., Perry, James C., Sanatani, Shubhayan, Seslar, Stephen P., Shetty, Ira, Zimmerman, Frank J., Skinner, Jonathan R., Marcondes, Luciana, Stephenson, Elizabeth A., Asakai, Hiroko, Tanel, Ronn E., Uzun, Orhan, Etheridge, Susan P., and Janson, Christopher M.

Published
2020
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39. Permanent conduction system pacing for congenitally corrected transposition of the great arteries: A Pediatric and Congenital Electrophysiology Society (PACES)/International Society for Adult Congenital Heart Disease (ISACHD) Collaborative Study

Author

Moore, Jeremy P., Gallotti, Roberto, Shannon, Kevin M., Pilcher, Thomas, Vinocur, Jeffrey M., Cano, Óscar, Kean, Adam, Mondesert, Blandine, Nürnberg, Jan-Hendrik, Schaller, Robert D., Sharma, Parikshit S., Nishimura, Takuro, and Tung, Roderick

Published
2020
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41. Risk factors for lethal arrhythmic events in children and adolescents with hypertrophic cardiomyopathy and an implantable defibrillator: An international multicenter study

Author

Balaji, Seshadri, DiLorenzo, Michael P., Fish, Frank A., Etheridge, Susan P., Aziz, Peter F., Russell, Mark W., Tisma, Svjetlana, Pflaumer, Andreas, Sreeram, Narayanswami, Kubus, Peter, Law, Ian H., Kantoch, Michal J., Kertesz, Naomi J., Strieper, Margaret, Erickson, Christopher C., Moore, Jeremy P., Nakano, Stephanie J., Singh, Harinder R., Chang, Philip, Cohen, Mitchell, Fournier, Anne, Ilina, Maria V., Smith, Richard T., Zimmerman, Frank, Horndasch, Michaela, Li, Walter, Batra, Anjan, Liberman, Leonardo, Hamilton, Robert, Janson, Christopher M., Sanatani, Shubhayan, Zeltser, Ilana, McDaniel, George, Blaufox, Andrew D., Garnreiter, Jason M., Katcoff, Hannah, and Shah, Maully

Published
2019
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42. Safety and outcomes of catheter ablation for atrial fibrillation in adults with congenital heart disease: A multicenter registry study

Author

Liang, Jackson J., Frankel, David S., Parikh, Valay, Lakkireddy, Dhanujaya, Mohanty, Sanghamitra, Burkhardt, J. David, Natale, Andrea, Szilagyi, Judit, Gerstenfeld, Edward P., Moore, Jeremy P., Collins, Kathryn K., Kay, Joseph D., Santangeli, Pasquale, Marchlinski, Francis E., Sauer, William H., and Nguyen, Duy T.

Published
2019
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43. Continuous-wave Cascaded-Harmonic Generation and Multi-Photon Raman Lasing in Lithium Niobate Whispering-Gallery Resonators

Author

Moore, Jeremy, Tomes, Matthew, Carmon, Tal, and Jarrahi, Mona

Subjects
Physics - Optics
Abstract

We report experimental demonstration of continuous-wave cascaded-harmonic generation and Raman lasing in a millimeter-scale lithium niobate whispering-gallery resonator pumped at a telecommunication-compatible infrared wavelength. Intensity enhancement through multiple recirculations in the whispering-gallery resonator and quasi phase-matching through a nonuniform crystal poling enable simultaneous cascaded-harmonic generation up to the fourth-harmonic accompanied by stimulated Raman, two-photon, three-photon, and four-photon Raman scattering corresponding the molecular vibrational wavenumbers 632 cm-1 and 255 cm-1 in z-cut lithium niobate at pump power levels as low as 200mW. We demonstrate simultaneous cascaded-harmonic generation and Raman lasing by observing the spectrum of the scattered light from the resonator and by capturing the image of the decoupled light from the resonator on a color CCD camera.

Published
2011
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45. Cardiology

Author

Reardon, Leigh C., primary, Wong, Vanessa L., additional, Gallotti, Roberto G., additional, and Moore, Jeremy P., additional

Published
2020
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46. Conduction System Pacing Versus Conventional Cardiac Resynchronization Therapy in Congenital Heart Disease

Author

Moore, Jeremy P, de Groot, Natasja M S, O'Connor, Matthew, Cortez, Daniel, Su, Jonathan, Burrows, Austin, Shannon, Kevin M, O'Leary, Edward T, Shah, Maully, Khairy, Paul, Atallah, Joseph, Wong, Tom, Lloyd, Michael S, Taverne, Yannick J H J, Dubin, Anne M, Nielsen, Jens C, Evertz, Reinder, Czosek, Richard J, Madhavan, Malini, Chang, Philip M, Aydin, Alper, Cano, Óscar, Cardiology, and Cardiothoracic Surgery

Subjects
All institutes and research themes of the Radboud University Medical Center, Vascular damage Radboud Institute for Health Sciences [Radboudumc 16]
Abstract

Item does not contain fulltext BACKGROUND: Dyssynchrony-associated left ventricular systolic dysfunction is a major contributor to heart failure in congenital heart disease (CHD). Although conventional cardiac resynchronization therapy (CRT) has shown benefit, the comparative efficacy of cardiac conduction system pacing (CSP) is unknown. OBJECTIVES: The purpose of this study was compare the clinical outcomes of CSP vs conventional CRT in CHD with biventricular, systemic left ventricular anatomy. METHODS: Retrospective CSP data from 7 centers were compared with propensity score-matched conventional CRT control subjects. Outcomes were lead performance, change in left ventricular ejection fraction (LVEF), and QRS duration at 12 months. RESULTS: A total of 65 CSP cases were identified (mean age 37 ± 21 years, 46% men). The most common CHDs were tetralogy of Fallot (n = 12 [19%]) and ventricular septal defect (n = 12 [19%]). CSP was achieved after a mean of 2.5 ± 1.6 attempts per procedure (38 patients with left bundle branch pacing, 17 with HBP, 10 with left ventricular septal myocardial). Left bundle branch area pacing [LBBAP] vs HBP was associated with a smaller increase in pacing threshold (Δ pacing threshold 0.2 V vs 0.8 V; P = 0.05) and similar sensing parameters at follow-up. For 25 CSP cases and control subjects with baseline left ventricular systolic dysfunction, improvement in LVEF was non-inferior (Δ LVEF 9.0% vs 6.0%; P = 0.30; 95% confidence limits: -2.9% to 10.0%) and narrowing of QRS duration was more pronounced for CSP (Δ QRS duration 35 ms vs 14 ms; P = 0.04). Complications were similar (3 [12%] CSP, 4 [16%] conventional CRT; P = 1.00). CONCLUSIONS: CSP can be reliably achieved in biventricular, systemic left ventricular CHD patients with similar improvement in LVEF and greater QRS narrowing for CSP vs conventional CRT at 1 year. Among CSP patients, pacing electrical parameters were superior for LBBAP vs HBP.

Published
2023

48. Life-Threatening Event Risk in Children With Wolff-Parkinson-White Syndrome: A Multicenter International Study

Author

Etheridge, Susan P., Escudero, Carolina A., Blaufox, Andrew D., Law, Ian H., Dechert-Crooks, Brynn E., Stephenson, Elizabeth A., Dubin, Anne M., Ceresnak, Scott R., Motonaga, Kara S., Skinner, Jonathan R., Marcondes, Luciana D., Perry, James C., Collins, Kathryn K., Seslar, Stephen P., Cabrera, Michel, Uzun, Orhan, Cannon, Bryan C., Aziz, Peter F., Kubuš, Peter, Tanel, Ronn E., Valdes, Santiago O., Sami, Sara, Kertesz, Naomi J., Maldonado, Jennifer, Erickson, Christopher, Moore, Jeremy P., Asakai, Hiroko, Mill, LuAnn, Abcede, Mark, Spector, Zebulon Z., Menon, Shaji, Shwayder, Mark, Bradley, David J., Cohen, Mitchell I., and Sanatani, Shubhayan

Published
2018
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49. Impact of Obesity on Left Ventricular Thickness in Children with Hypertrophic Cardiomyopathy

Author

Balaji, Seshadri, DiLorenzo, Michael P., Fish, Frank A., Etheridge, Susan P., Aziz, Peter F., Russell, Mark W., Tisma, Svjetlana, Pflaumer, Andreas, Sreeram, Narayanswami, Kubus, Peter, Law, Ian H., Kantoch, Michal J., Kertesz, Naomi J., Strieper, Margaret, Erickson, Christopher C., Moore, Jeremy P., Nakano, Stephanie J., Singh, Harinder R., Chang, Philip, Cohen, Mitchell, Fournier, Anne, Ilina, Maria V., Smith, Richard T., Zimmerman, Frank, Horndasch, Michaela, Li, Walter, Batra, Anjan, Liberman, Leonardo, Hamilton, Robert, Janson, Christopher M., Sanatani, Shubhayan, Zeltser, Ilana, McDaniel, George, Blaufox, Andrew D., Garnreiter, Jason M., Katcoff, Hannah, and Shah, Maully

Published
2019
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50. Intrahepatic transcriptomics differentiate advanced fibrosis and clinical outcomes in adults with the Fontan circulation

Author

Bravo-Jaimes, Katia, primary, Wu, Xiuju, additional, Reardon, Leigh C, additional, Lluri, Gentian, additional, Lin, Jeannette P, additional, Moore, Jeremy P, additional, Arsdell, Glen Van, additional, Biniwale, Reshma, additional, Si, Ming-Sing, additional, Naini, Bita V, additional, Venick, Robert, additional, Saab, Sammy, additional, Wray, Christopher L, additional, Ponder, Reid, additional, Rosenthal, Carl, additional, Klomhaus, Alexandra, additional, Böstrom, Kristina I, additional, Aboulhosn, Jamil A, additional, and Kaldas, Fady M, additional

Published
2023
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