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6. Invasive pneumococcal disease in children under 60 months before and after availability of 13-valent conjugate vaccine

Author

Martínez-Osorio, Johanna, García-García, Juan José, Moraga-Llop, Fernando, Díaz, Alvaro, Hernández, Sergi, Solé-Ribalta, Anna, González-Peris, Sebastià, Izquierdo, Conchita, Esteva, Cristina, Codina, Gemma, Planes, Ana María, Uriona, Sonia, Campins, Magda, Ciruela, Pilar, Salleras, Luis, Domínguez, Ángela, Muñoz-Almagro, Carmen, and de Sevilla, Mariona F.

Published
2022
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7. Enfermedad neumocócica invasiva en niños menores de 60 meses, antes y después de la introducción de la vacuna conjugada 13-valente

Author

Martínez-Osorio, Johanna, García-García, Juan José, Moraga-Llop, Fernando, Díaz, Alvaro, Hernández, Sergi, Solé-Ribalta, Anna, González-Peris, Sebastià, Izquierdo, Conchita, Esteva, Cristina, Codina, Gemma, Planes, Ana María, Uriona, Sonia, Campins, Magda, Ciruela, Pilar, Salleras, Luis, Domínguez, Ángela, Muñoz-Almagro, Carmen, and de Sevilla, Mariona F

Published
2022
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8. Necrotizing pneumonia due to Streptococcus pneumoniae in children during the period of non-systematic use of PCV13 in Catalonia, Spain

Author

González-Peris, Sebastià, Campins, Magda, García-García, Juan José, Díaz-Conradi, Álvaro, Domínguez, Ángela, Ciruela, Pilar, de Sevilla, Mariona F., Hernández, Sergi, Muñoz-Almagro, Carmen, Izquierdo, Conchita, Codina, Gemma, Uriona, Sonia, Esteva, Cristina, Solé-Ribalta, Anna, Soldevila, Núria, Planes, Ana María, Martínez-Osorio, Johanna, Salleras, Luis, and Moraga-Llop, Fernando

Published
2021
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9. Characteristics of patients with invasive pneumococcal disease requiring admission to intensive care units

Author

García García, Juan José, Domínguez, Angela, Moraga Llop, Fernando, Díaz Conradi, Alvaro, de Sevilla, Mariona Fernández, González Peris, Sebastià, Ciruela, Pilar, Campins, Magda, Muñoz-Almagro, Carmen, Esteva, Cristina, Izquierdo, Conchita, Uriona, Sonia, Martínez Osorio, Johanna, Solé Ribalta, Anna, Codina, Gemma, Soldevila, Nuria, Salleras Sanmartí, Lluís, Díaz-Conradi, Alvaro, García-García, Juan José, Fernández de Sevilla, Mariona, and Ventura, Paula Sol

Published
2021
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10. Características de los pacientes con enfermedad neumocócica invasora que requieren ingreso en la unidad de cuidados intensivos

Author

Díaz-Conradi, Alvaro, García-García, Juan José, González Peris, Sebastià, Fernández de Sevilla, Mariona, Moraga Llop, Fernando, Ventura, Paula Sol, Domínguez, Angela, de Sevilla, Mariona Fernández, Ciruela, Pilar, Campins, Magda, Muñoz-Almagro, Carmen, Esteva, Cristina, Izquierdo, Conchita, Uriona, Sonia, Martínez Osorio, Johanna, Solé Ribalta, Anna, Codina, Gemma, Soldevila, Nuria, and Salleras Sanmartí, Lluís

Published
2021
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13. Failures of 13-Valent Conjugated Pneumococcal Vaccine in Age-Appropriately Vaccinated Children 2-59 Months of Age, Spain

Author

Hernandez, Sergi, Moraga-Llop, Fernando, Diaz, Alvaro, de Sevilla, Mariona F., Ciruela, Pilar, Munoz-Almagro, Carmen, Codina, Gemma, Campins, Magda, Garcia-Garcia, Juan Jose, Esteva, Cristina, Izquierdo, Conchita, Gonzalez-Peris, Sebastia, Martinez-Osorio, Johanna, Uriona, Sonia, Salleras, Luis, and Dominguez, Angela

Subjects
Diseases, Research, Children's hospitals -- Research, Pneumonia -- Research, Pediatrics -- Research, Vaccination -- Research
Abstract

Conjugated pneumococcal vaccines have been shown to be effective in preventing invasive pneumococcal disease (IPD) in children. In February 2001, the European Medicines Agency (EMA) authorized the use of the [...]

Published
2020
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17. Meningococcal meningitis in Spain in the Horizon 2030: A position paper.

Author

Moraga-Llop, Fernando, Andradas, Elena, Blesa-Baviera, Luis Carlos, Cantón, Rafael, González del Castillo, Juan, Martinón-Torres, Federico, Moya, Elena, Trilla, Antoni, Vazquez, Julio, Villena, Rodolfo Javier, Ruiz-Galiana, Julián, De Lucas Ramos, Pilar, García-Botella, Alejandra, García-Lledó, Alberto, Hernández-Sampelayo, Teresa, Gómez-Pavón, Javier, Martín-Delgado, Mari Cruz, Martín Sánchez, Francisco Javier, Martínez-Sellés, Manuel, and Molero García, José María

Subjects
MENINGOCOCCAL infections, NEISSERIA meningitidis, MENINGITIS, VACCINES, EPIDEMICS, ANTI-infective agents, CHEMOPREVENTION
Abstract

Copyright of Revista Española de Quimioterapia is the property of Sociedad Espanola de Quimioterapia and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Published
2024
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22. Update on Bimervax® immunogenicity amplitude. Insights on humoral response against XBB.1.5 from an extension study (NTC05142553)

Author

Borralleras, Cristina, primary, Castrodeza Sanz, Javier, additional, Arrazola, Pilar, additional, Cámara Hijón, Carmen, additional, Eiros, José Mª, additional, Fernández-Prada, María, additional, Gil de Miguel, Ángel, additional, Mirada Masip, Gloria, additional, Moraga-Llop, Fernando, additional, Ocaña Rodríguez, Daniel, additional, Puig-Barberà, Joan, additional, Vázquez, Jorge, additional, Vergara-Alert, Júlia, additional, and de Cambra, Salomé, additional

Published
2023
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25. The PHH-1V HIPRA vaccine: a new tool in the vaccination strategy against COVID-19

Author

Borralleras, Cristina, primary, Castrodeza Sanz, Javier, additional, Arrazola, Pilar, additional, Cámara Hijón, Carmen, additional, Eiros, José Mª, additional, Fernández-Prada, María, additional, Gil de Miguel, Ángel, additional, Mirada Masip, Gloria, additional, Moraga-Llop, Fernando, additional, Ocaña Rodríguez, Daniel, additional, Puig-Barberà, Joan, additional, Vázquez, Jorge, additional, Vergara-Alert, Júlia, additional, and de Cambra, Salomé, additional

Published
2023
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30. Changes in Invasive Pneumococcal Disease in the Paediatric Population in the Second COVID-19 Pandemic Year.

Author

Izquierdo, Conchita, Ciruela, Pilar, Soldevila, Núria, Garcia-Garcia, Juan-Jose, Gonzalez-Peris, Sebastia, Díaz-Conradi, Alvaro, Viñado, Belen, F de Sevilla, Mariona, Moraga-Llop, Fernando, Muñoz-Almagro, Carmen, and Domínguez, Angela

Subjects
COVID-19 pandemic, CHILD patients, DIAGNOSTIC use of polymerase chain reaction, AGE groups, HOSPITAL emergency services
Abstract

Incidence of invasive pneumococcal disease (IPD) decreased worldwide in 2020, coinciding with the implementation of measures to reduce COVID-19 transmission. We evaluated the impact of the COVID-19 pandemic on healthcare demand and IPD in children in 2021 compared to the pre-pandemic period (2018–2019) and the early pandemic period (2020) in a study carried out during 2018–2021 in Catalonia. Incidence rates were compared by calculating the incidence rate ratio (IRR), and expressing percentage changes in IRR as (1-IRR)x100. Compared to 2018–2019, emergency room (ER) visits declined by 21% in 2021 (p < 0.001), mainly in the first quarter (−39%), and compared to 2020, ER visits increased by 22% in 2021 (p < 0.001), except in the first quarter. IPD incidence overall was 11.0 in 2018–2019 and 4.6 in 2021 (−58%, p < 0.001); the reduction in incidence was similar in the 0–4 age group and was higher in the first quarters. Compared to 2020, in 2021, IPD incidence decreased during the first quarter (−86%, p < 0.001), but increased from 0.0 to 1.2 in the second quarter (p = 0.02) and from 0.6 to 2.1 (p=0.03) in the fourth quarter. The decreased IPD incidence observed in 2021 compared to 2018–2019 (most especially in the first quarter) was greater than the decrease in healthcare demand and PCR test requests. Compared to 2020, IPD incidence decreased in the first quarter when a second state of alarm was in force. In 2021, compared to 2018–2019, there was a greater reduction in PCV13 serotypes than in non-PCV13 serotypes. [ABSTRACT FROM AUTHOR]

Published
2023
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42. Enfermedad neumocócica invasiva en niños menores de 60 meses, antes y después de la introducción de la vacuna conjugada 13-valente

Author

Martínez-Osorio, Johanna, primary, García-García, Juan José, additional, Moraga-Llop, Fernando, additional, Díaz, Alvaro, additional, Hernández, Sergi, additional, Solé-Ribalta, Anna, additional, González-Peris, Sebastià, additional, Izquierdo, Conchita, additional, Esteva, Cristina, additional, Codina, Gemma, additional, Planes, Ana María, additional, Uriona, Sonia, additional, Campins, Magda, additional, Ciruela, Pilar, additional, Salleras, Luis, additional, Domínguez, Ángela, additional, Muñoz-Almagro, Carmen, additional, and de Sevilla, Mariona F, additional

Published
2021
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44. Characteristics of patients with invasive pneumococcal disease requiring admission to intensive care units

Author

Díaz-Conradi, Alvaro, primary, García-García, Juan José, additional, González Peris, Sebastià, additional, Fernández de Sevilla, Mariona, additional, Moraga Llop, Fernando, additional, Ventura, Paula Sol, additional, Domínguez, Angela, additional, García García, Juan José, additional, Díaz Conradi, Alvaro, additional, de Sevilla, Mariona Fernández, additional, Ciruela, Pilar, additional, Campins, Magda, additional, Muñoz-Almagro, Carmen, additional, Esteva, Cristina, additional, Izquierdo, Conchita, additional, Uriona, Sonia, additional, Martínez Osorio, Johanna, additional, Solé Ribalta, Anna, additional, Codina, Gemma, additional, Soldevila, Nuria, additional, and Salleras Sanmartí, Lluís, additional

Published
2021
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45. Erratum for Hernández et al., “Invasive Pneumococcal Disease and Influenza Activity in a Pediatric Population: Impact of PCV13 Vaccination in Epidemic and Nonepidemic Influenza Periods”

Author

Hernández, Sergi, primary, Muñoz-Almagro, Carmen, additional, Ciruela, Pilar, additional, Soldevila, Núria, additional, Izquierdo, Conchita, additional, Codina, Maria Gemma, additional, Díaz, Alvaro, additional, Moraga-Llop, Fernando, additional, García-García, Juan José, additional, and Domínguez, Ángela, additional

Published
2020
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46. Impact of the 13-Valent Conjugated Pneumococcal Vaccine on the Direct Costs of Invasive Pneumococcal Disease Requiring Hospital Admission in Children Aged < 5 Years: A Prospective Study

Author

Hernández, Sergi, primary, Navas, Encarna, additional, Aznar-Lou, Ignacio, additional, Ciruela, Pilar, additional, García-García, Juan José, additional, Moraga-Llop, Fernando, additional, Muñoz-Almagro, Carmen, additional, Codina, Gemma, additional, F. de Sevilla, Mariona F., additional, González-Peris, Sebastià, additional, Esteva, Cristina, additional, Planes, Ana María, additional, Izquierdo, Conchita, additional, Martínez-Osorio, Johanna, additional, Campins, Magda, additional, Uriona, Sonia, additional, Salleras, Luis, additional, Serrano-Blanco, Antoni, additional, Jané, Mireia, additional, and Domínguez, Ángela, additional

Published
2020
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47. Prognostic factors in meningococcal disease: development of a bedside predictive model and scoring system

Author

Barquet, Nicolau, Domingo, Pere, Cayla, Joan A., Gonzalez, Julia, Rodrigo, Carlos, Fernandez-Viladrich, Pedro, Moraga-Llop, Fernando A., Marco, Francesc, Vazquez, Julio, Saez-Nieto, Juan A., Casal, Julio, Canela, Jaume, and Foz, Marius

Subjects
Meningococcal infections -- Prognosis, Hemorrhage -- Health aspects
Abstract

Hemorrhagic diathesis, focal neurologic signs and age 60 years or older may be signs of a poor prognosis in patients with meningococcal infections. These infections are caused by the bacterium Neisseria meningitidis. Researchers compared physical signs apparent at the clinical examination with mortality rates in 907 patients with meningococcal infections. Patients with the highest mortality rates were 60 or older, had muscle or sensory evidence of central nervous system damage and hemorrhagic diathesis. Hemorrhagic diathesis is characterized by spontaneous bleeding from mucous membranes and other sites., Context. -- Meningococcal disease is associated with significant morbidity and mortality. Development of a prognostic model based on clinical findings may be useful for identification and management of patients with meningococcal infection. Objectives. -- To construct and validate a bedside model and scoring system for prognosis in meningococcal disease. Design. -- Prospective, population-based study. Setting. -- Twenty-four hospitals in the metropolitan area of Barcelona, Spain. Patients. -- A total of 907 patients with microbiologically proven meningococcal disease. Patients diagnosed with meningococcal disease from 1987 through 1990 were used to develop the prognostic model, and those diagnosed in 1991 and 1992 were used to validate it. Outcome Measures. -- Clinical independent prognostic factors for mortality in meningococcal disease. The association between outcome and independent prognostic factors was determined by logistic regression analysis. A scoring system was constructed and tested using receiver operating characteristic curves. Results. -- among 624 patients in the derivation set, 287 (46%) were male, the mean age was 12.4 years, and 34 patients (5.40%) died. Among 283 patients in the validation set, 124 (43.8%) were male, the mean age was 12.7 years, and 17 patients (6.0%) died. In multivariate analysis, independent predictors of death were hemorrhagic diathesis (odds ratio [OR], 101; 95% confidence interval [Cl], 30-333), focal neurologic signs (OR, 25; 95% Cl, 7-83), and age 60 years or older (OR, 10; 95% Cl, 3-34), whereas receipt of adequate antibiotic therapy prior to admission was associated with reduced likelihood of death (OR, 0.09; 95% Cl, 0.02-0.4). Hemorrhagic diathesis was scored with 2 points, presence of focal neurologic signs with 1 point, age of 60 years or older with 1 point, and preadmission antibiotic therapy was scored as -1. The clinical scores of -1, 0, 1, 2, and 3 or more points were associated with a probability of death of 0%, 2.3%, 27.3%, 73.3%, and 100%, respectively. Conclusions. -- Hemorrhagic diathesis, focal neurologic signs, and age of 60 years or older were independent predictors of death in meningococcal disease, whereas receipt of adequate antibiotic therapy was associated with a more favorable prognosis. The scoring system presented is simple, is based on findings readily available at the bedside, and may be useful to help guide aggressive therapy.

Published
1997

50. Epidemiological, Clinical, and Microbiological Characteristics of Serotype-3 Streptoccocus pneumoniae Infection after a Partial Introduction of the 13-Valent Pneumococcal Conjugate Vaccine: A Prospective Observational Study

Author

Solé-Ribalta, Anna, additional, de Sevilla, Maria F., additional, Moraga-Llop, Fernando, additional, Conradi, Alvaro D., additional, Hernández, Sergi, additional, Martínez-Osorio, Johanna, additional, González-Peris, Sebastià, additional, Izquierdo, Conchita, additional, Esteva, Cristina, additional, Codina, Gemma, additional, Planes, Ana M., additional, Uriona, Sonia, additional, Campins, Magda, additional, Ciruela, Pilar, additional, Salleras, Luis, additional, Domínguez, Ángela, additional, Muñoz-Almagro, Carmen, additional, and García-Garcia, Juan J., additional

Published
2020
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