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326 results on '"Moraleda, Cinta"'

1. Twice-Daily Dosing of Dolutegravir in Infants on Rifampicin Treatment: A Pharmacokinetic Substudy of the EMPIRICAL Trial.

Author

Jacobs, Tom, Mumbiro, Vivian, Cassia, Uneisse, Zimba, Kevin, Nalwanga, Damalie, Ballesteros, Alvaro, Domínguez-Rodríguez, Sara, Tagarro, Alfredo, Madrid, Lola, Mutata, Constantine, Chitsamatanga, Moses, Bwakura-Dangarembizi, Mutsa, Passanduca, Alfeu, Buck, W, Nduna, Bwendo, Chabala, Chishala, Najjingo, Elizabeth, Musiime, Victor, Moraleda, Cinta, Colbers, Angela, Mujuru, Hilda, Rojo, Pablo, and Burger, David

Subjects
HIV, dolutegravir, drug–drug interaction, infants, rifampicin, Female, Humans, Infant, Male, Heterocyclic Compounds, 3-Ring, HIV, HIV Infections, Oxazines, Piperazines, Pyridones, Rifampin
Abstract

BACKGROUND: We evaluated dolutegravir pharmacokinetics in infants with human immunodeficiency virus (HIV) receiving dolutegravir twice daily (BID) with rifampicin-based tuberculosis (TB) treatment compared with once daily (OD) without rifampicin. METHODS: Infants with HIV aged 1-12 months, weighing ≥3 kg, and receiving dolutegravir BID with rifampicin or OD without rifampicin were eligible. Six blood samples were taken over 12 (BID) or 24 hours (OD). Dolutegravir pharmacokinetic parameters, HIV viral load (VL) data, and adverse events (AEs) were reported. RESULTS: Twenty-seven of 30 enrolled infants had evaluable pharmacokinetic curves. The median (interquartile range) age was 7.1 months (6.1-9.9), weight was 6.3 kg (5.6-7.2), 21 (78%) received rifampicin, and 11 (41%) were female. Geometric mean ratios comparing dolutegravir BID with rifampicin versus OD without rifampicin were area under curve (AUC)0-24h 0.91 (95% confidence interval, .59-1.42), Ctrough 0.95 (0.57-1.59), Cmax 0.87 (0.57-1.33). One infant (5%) receiving rifampicin versus none without rifampicin had dolutegravir Ctrough

Published
2024

2. First-Line Antituberculosis Drug Concentrations in Infants With HIV and a History of Recent Admission With Severe Pneumonia.

Author

Chabala, Chishala, Jacobs, Tom, Moraleda, Cinta, Ndaferankhande, John, Mumbiro, Vivian, Passanduca, Alfeu, Namuziya, Natasha, Nalwanga, Damalie, Musiime, Victor, Ballesteros, Alvaro, Domínguez-Rodríguez, Sara, Chitsamatanga, Moses, Cassia, Uneisse, Nduna, Bwendo, Bramugy, Justina, Sacarlal, Jahit, Madrid, Lola, Nathoo, Kusum, Colbers, Angela, Burger, David, Mulenga, Veronica, Buck, William, Mujuru, Hilda, Te Brake, Lindsey, Rojo, Pablo, Tagarro, Alfredo, and Aarnoutse, Rob

Subjects
HIV, HRZE, Tuberculosis, infants, pharmacokinetics, Adult, Infant, Humans, Antitubercular Agents, HIV Infections, Pneumonia, Reference Values
Abstract

Optimal antituberculosis therapy is essential for favorable clinical outcomes. Peak plasma concentrations of first-line antituberculosis drugs in infants with living HIV receiving WHO-recommended dosing were low compared with reference values for adults, supporting studies on increased doses of first-line TB drugs in infants.

Published
2023

3. Brief Report: Suboptimal Lopinavir Exposure in Infants on Rifampicin Treatment Receiving Double-dosed or Semisuperboosted Lopinavir/Ritonavir: Time for a Change

Author

Jacobs, Tom G, Mumbiro, Vivian, Chitsamatanga, Moses, Namuziya, Natasha, Passanduca, Alfeu, Domínguez-Rodríguez, Sara, Tagarro, Alfredo, Nathoo, Kusum J, Nduna, Bwendo, Ballesteros, Alvaro, Madrid, Lola, Mujuru, Hilda A, Chabala, Chishala, Buck, W Chris, Rojo, Pablo, Burger, David M, Moraleda, Cinta, and Colbers, Angela

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Pediatric, HIV/AIDS, Infectious Diseases, Clinical Research, Clinical Trials and Supportive Activities, Pediatric AIDS, Evaluation of treatments and therapeutic interventions, 6.1 Pharmaceuticals, Infection, Good Health and Well Being, Male, Infant, Humans, Child, Female, Lopinavir, Ritonavir, Rifampin, HIV Infections, Anti-HIV Agents, HIV Protease Inhibitors, lopinavir, infants, rifampin, HIV, tuberculosis, drug-drug interaction, EMPIRICAL Clinical Trial Group, Public Health and Health Services, Virology, Clinical sciences, Epidemiology, Public health
Abstract

BackgroundAlthough super-boosted lopinavir/ritonavir (LPV/r; ratio 4:4 instead of 4:1) is recommended for infants living with HIV and receiving concomitant rifampicin, in clinical practice, many different LPV/r dosing strategies are applied due to poor availability of pediatric separate ritonavir formulations needed to superboost. We evaluated LPV pharmacokinetics in infants with HIV receiving LPV/r dosed according to local guidelines in various sub-Saharan African countries with or without rifampicin-based tuberculosis (TB) treatment.MethodsThis was a 2-arm pharmacokinetic substudy nested within the EMPIRICAL trial (#NCT03915366). Infants aged 1-12 months recruited into the main study were administered LPV/r according to local guidelines and drug availability either with or without rifampicin-based TB treatment; during rifampicin cotreatment, they received double-dosed (ratio 8:2) or semisuperboosted LPV/r (adding a ritonavir 100 mg crushed tablet to the evening LPV/r dose). Six blood samples were taken over 12 hours after intake of LPV/r.ResultsIn total, 14/16 included infants had evaluable pharmacokinetic curves; 9/14 had rifampicin cotreatment (5 received double-dosed and 4 semisuperboosted LPV/r). The median (IQR) age was 6.4 months (5.4-9.8), weight 6.0 kg (5.2-6.8), and 10/14 were male. Of those receiving rifampicin, 6/9 infants (67%) had LPV Ctrough

Published
2023

4. Empirical treatment against cytomegalovirus and tuberculosis in HIV-infected infants with severe pneumonia: study protocol for a multicenter, open-label randomized controlled clinical trial

Author

Rojo, Pablo, Moraleda, Cinta, Tagarro, Alfredo, Domínguez-Rodríguez, Sara, Castillo, Lola Madrid, Tato, Luis Manuel Prieto, López, Aranzazu Sancho, Manukyan, Lilit, Marcy, Olivier, Leroy, Valeriane, Nardone, Alessandra, Burger, David, Bassat, Quique, Bates, Matthew, Moh, Raoul, Iroh Tam, Pui-Ying, Mvalo, Tisungane, Magallhaes, Justina, Buck, W Chris, Sacarlal, Jahit, Musiime, Victor, Chabala, Chishala, and Mujuru, Hilda Angela

Subjects
Medical Microbiology, Biomedical and Clinical Sciences, Rare Diseases, Pneumonia, Clinical Trials and Supportive Activities, Tuberculosis, Pediatric, Patient Safety, HIV/AIDS, Clinical Research, Pneumonia & Influenza, Lung, Orphan Drug, Infectious Diseases, Evaluation of treatments and therapeutic interventions, 6.1 Pharmaceuticals, Infection, Good Health and Well Being, Child, Clinical Trials, Phase II as Topic, Cytomegalovirus, Cytomegalovirus Infections, HIV Infections, Humans, Infant, Multicenter Studies as Topic, Randomized Controlled Trials as Topic, Treatment Outcome, Valganciclovir, Factorial, Empirical, HIV, Infants, Child mortality, Factorial randomized clinical trial, Cardiorespiratory Medicine and Haematology, Clinical Sciences, Cardiovascular System & Hematology, General & Internal Medicine, Clinical sciences, Epidemiology, Health services and systems
Abstract

BackgroundPneumonia is the primary cause of death among HIV-infected children in Africa, with mortality rates as high as 35-40% in infants hospitalized with severe pneumonia. Bacterial pathogens and Pneumocystis jirovecii are well known causes of pneumonia-related death, but other important causes such as cytomegalovirus (CMV) and tuberculosis (TB) remain under-recognized and undertreated. The immune response elicited by CMV may be associated with the risk of developing TB and TB disease progression, and CMV may accelerate disease caused both by HIV and TB. Minimally invasive autopsies confirm that CMV and TB are unrecognized causes of death in children with HIV. CMV and TB may also co-infect the same child. The aim of this study is to compare the impact on 15-day and 1-year mortality of empirical treatment against TB and CMV plus standard of care (SoC) versus SoC in HIV-infected infants with severe pneumonia.MethodsThis is a Phase II-III, open-label randomized factorial (2 × 2) clinical trial, conducted in six African countries. The trial has four arms. Infants from 28 to 365 days of age HIV-infected and hospitalized with severe pneumonia will be randomized (1:1:1:1) to (i) SoC, (ii) valganciclovir, (iii) TB-T, and (iv) TB-T plus valganciclovir. The primary endpoint of the study is all-cause mortality, focusing on the short-term (up to 15 days) and long-term (up to 1 year) mortality. Secondary endpoints include repeat hospitalization, duration of oxygen therapy during initial admission, severe and notable adverse events, adverse reactions, CMV and TB prevalence at enrolment, TB incidence, CMV viral load reduction, and evaluation of diagnostic tests such as GeneXpert Ultra on fecal and nasopharyngeal aspirate samples and urine TB-LAM.DiscussionGiven the challenges in diagnosing CMV and TB in children and results from previous autopsy studies that show high rates of poly-infection in HIV-infected infants with respiratory disease, this study aims to evaluate a new approach including empirical treatment of CMV and TB for this patient population. The potential downsides of empirical treatment of these conditions include toxicity and medication interactions, which will be evaluated with pharmacokinetics sub-studies.Trial registrationClinicalTrials.gov , NCT03915366, Universal Trial Number U111-1231-4736, Pan African Clinical Trial Registry PACTR201994797961340.

Published
2022

6. Clinical outcomes and antibody transfer in a cohort of infants with in utero or perinatal exposure to SARS-CoV-2 (Coronascope Study)

Author

Carrasco Colom, Jaime, Manzanares, Ángela, Álvaro Gómez, Alicia, Serrano Escribano, Isabel, Esquivel, Estrella, Pérez-Rivilla, Alfredo, Moral-Pumarega, Maria Teresa, Aguirre Pascual, Elisa, De Vergas, Joaquín, Reda del Barrio, Sara, Moraleda, Cinta, Epalza, Cristina, Fernández-Cooke, Elisa, Prieto, Luis, Villaverde, Serena, Zamora, Berta, Herraiz, Ignacio, Galindo, Alberto, Folgueira, María Dolores, Delgado, Rafael, and Blázquez-Gamero, Daniel

Published
2023
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7. T-Cell Immune Responses in Newborns and Long-Term Sequelae in Congenital Cytomegalovirus Infection (CYTRIC Study)

Author

Hernández, Judith, Pisón, Raquel Pinillos, Arnaiz, Eneritz Velasco, Villaverde, Serena, Vila, Sara, Rojo, Pablo, Epalza, Cristina, Moraleda, Cinta, Cooke, Elisa Fernández, Prieto, Luis, Zamora, Berta, Martínez de Aragón, Ana, Simón, Rogelio, Camacho, Ana, Machín, Fátima, Cabello, Laura, Romero, María Luz, Serna, Miquel, Martín, Marta, Esquivel-De la Fuente, Estrella, Calle, María de la, Rodríguez, Sara Domínguez, Cabanes, María, Gómez-Montes, Enery, Goncé, Anna, Bango, Marta Valdés, Viñuela-Benéitez, M<ce:sup loc='post">a</ce:sup> Carmen, Muñoz-Chápuli Gutiérrez, Mar, Pérez, Irene Cuadrado, Encinas, Begoña, Tagarro, Alfredo, Alcázar, Diana García, Burguillo, Antonio García, Martín, Roser Díez, Calavia, Olga, Salvia, Dolors, Olabarrieta, Iciar, Xiberta, Joan Manel, Jiménez Losa, Luz María, Soriano-Ramos, María, Pedrero-Tomé, Roberto, Giménez-Quiles, Estela, Albert, Eliseo, Baquero-Artigao, Fernando, Rodríguez-Molino, Paula, del Rosal, Teresa, Noguera-Julian, Antoni, Fortuny, Clàudia, Ríos-Barnés, María, Saavedra-Lozano, Jesús, Dueñas, Eva, Sánchez-Mateos, Miguel, Castells, Laura, de la Serna, María, Frick, Marie Antoinette, de Vergas, Joaquín, Núñez-Enamorado, Noemí, Moral-Pumarega, María Teresa, Folgueira, María Dolores, Navarro, David, and Blázquez-Gamero, Daniel

Published
2024
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9. Clinical phenotypes and outcomes in children with multisystem inflammatory syndrome across SARS-CoV-2 variant eras: a multinational study from the 4CE consortium

Author

Aaron, James R., Adam, Atif, Agapito, Giuseppe, Albayrak, Adem, Albi, Giuseppe, Alessiani, Mario, Alloni, Anna, Amendola, Danilo F., Angoulvant, François, Anthony, Li LLJ., Aronow, Bruce J., Ashraf, Fatima, Atz, Andrew, Avillach, Paul, Panickan, Vidul Ayakulangara, Azevedo, Paula S., Badenes, Rafael, Balshi, James, Batugo, Ashley, Beaulieu-Jones, Brendin R., Beaulieu-Jones, Brett K., Bell, Douglas S., Bellasi, Antonio, Bellazzi, Riccardo, Benoit, Vincent, Beraghi, Michele, Bernal-Sobrino, José Luis, Bernaux, Mélodie, Bey, Romain, Bhatnagar, Surbhi, Blanco-Martínez, Alvar, Boeker, Martin, Bonzel, Clara-Lea, Booth, John, Bosari, Silvano, Bourgeois, Florence T., Bradford, Robert L., Brat, Gabriel A., Bréant, Stéphane, Brown, Nicholas W., Bruno, Raffaele, Bryant, William A., Bucalo, Mauro, Bucholz, Emily, Burgun, Anita, Cai, Tianxi, Cannataro, Mario, Carmona, Aldo, Cattelan, Anna Maria, Caucheteux, Charlotte, Champ, Julien, Chen, Jin, Chen, Krista Y., Chiovato, Luca, Chiudinelli, Lorenzo, Cho, Kelly, Cimino, James J., Colicchio, Tiago K., Cormont, Sylvie, Cossin, Sébastien, Craig, Jean B., Cruz-Bermúdez, Juan Luis, Cruz-Rojo, Jaime, Dagliati, Arianna, Daniar, Mohamad, Daniel, Christel, Das, Priyam, Devkota, Batsal, Dionne, Audrey, Duan, Rui, Dubiel, Julien, DuVall, Scott L., Esteve, Loic, Estiri, Hossein, Fan, Shirley, Follett, Robert W., Ganslandt, Thomas, García-Barrio, Noelia, Garmire, Lana X., Gehlenborg, Nils, Getzen, Emily J., Geva, Alon, Goh, Rachel SJ., González, Tomás González, Gradinger, Tobias, Gramfort, Alexandre, Griffier, Romain, Griffon, Nicolas, Grisel, Olivier, Gutiérrez-Sacristán, Alba, Guzzi, Pietro H., Han, Larry, Hanauer, David A., Haverkamp, Christian, Hazard, Derek Y., He, Bing, Henderson, Darren W., Hilka, Martin, Ho, Yuk-Lam, Holmes, John H., Honerlaw, Jacqueline P., Hong, Chuan, Huling, Kenneth M., Hutch, Meghan R., Issitt, Richard W., Jannot, Anne Sophie, Jouhet, Vianney, Kainth, Mundeep K., Kate, Kernan F., Kavuluru, Ramakanth, Keller, Mark S., Kennedy, Chris J., Kernan, Kate F., Key, Daniel A., Kirchoff, Katie, Klann, Jeffrey G., Kohane, Isaac S., Krantz, Ian D., Kraska, Detlef, Krishnamurthy, Ashok K., L'Yi, Sehi, Leblanc, Judith, Lemaitre, Guillaume, Lenert, Leslie, Leprovost, Damien, Liu, Molei, Will Loh, Ne Hooi, Long, Qi, Lozano-Zahonero, Sara, Luo, Yuan, Lynch, Kristine E., Mahmood, Sadiqa, Maidlow, Sarah E., Makoudjou, Adeline, Makwana, Simran, Malovini, Alberto, Mandl, Kenneth D., Mao, Chengsheng, Maram, Anupama, Maripuri, Monika, Martel, Patricia, Martins, Marcelo R., Marwaha, Jayson S., Masino, Aaron J., Mazzitelli, Maria, Mazzotti, Diego R., Mensch, Arthur, Milano, Marianna, Minicucci, Marcos F., Moal, Bertrand, Ahooyi, Taha Mohseni, Moore, Jason H., Moraleda, Cinta, Morris, Jeffrey S., Morris, Michele, Moshal, Karyn L., Mousavi, Sajad, Mowery, Danielle L., Murad, Douglas A., Murphy, Shawn N., Naughton, Thomas P., Breda Neto, Carlos Tadeu, Neuraz, Antoine, Newburger, Jane, Ngiam, Kee Yuan, Njoroge, Wanjiku FM., Norman, James B., Obeid, Jihad, Okoshi, Marina P., Olson, Karen L., Omenn, Gilbert S., Orlova, Nina, Ostasiewski, Brian D., Palmer, Nathan P., Paris, Nicolas, Patel, Lav P., Pedrera-Jiménez, Miguel, Pfaff, Ashley C., Pfaff, Emily R., Pillion, Danielle, Pizzimenti, Sara, Priya, Tanu, Prokosch, Hans U., Prudente, Robson A., Prunotto, Andrea, Quirós-González, Víctor, Ramoni, Rachel B., Raskin, Maryna, Rieg, Siegbert, Roig-Domínguez, Gustavo, Rojo, Pablo, Romero-Garcia, Nekane, Rubio-Mayo, Paula, Sacchi, Paolo, Sáez, Carlos, Salamanca, Elisa, Samayamuthu, Malarkodi Jebathilagam, Sanchez-Pinto, L. Nelson, Sandrin, Arnaud, Santhanam, Nandhini, Santos, Janaina C.C., Sanz Vidorreta, Fernando J., Savino, Maria, Schriver, Emily R., Schubert, Petra, Schuettler, Juergen, Scudeller, Luigia, Sebire, Neil J., Serrano-Balazote, Pablo, Serre, Patricia, Serret-Larmande, Arnaud, Shah, Mohsin A., Hossein Abad, Zahra Shakeri, Silvio, Domenick, Sliz, Piotr, Son, Jiyeon, Sonday, Charles, South, Andrew M., Sperotto, Francesca, Spiridou, Anastasia, Strasser, Zachary H., Tan, Amelia LM., Tan, Bryce W.Q., Tan, Byorn W.L., Tanni, Suzana E., Taylor, Deanne M., Terriza-Torres, Ana I., Tibollo, Valentina, Tippmann, Patric, Toh, Emma MS., Torti, Carlo, Trecarichi, Enrico M., Vallejos, Andrew K., Varoquaux, Gael, Vella, Margaret E., Verdy, Guillaume, Vie, Jill-Jênn, Visweswaran, Shyam, Vitacca, Michele, Wagholikar, Kavishwar B., Waitman, Lemuel R., Wang, Xuan, Wassermann, Demian, Weber, Griffin M., Wolkewitz, Martin, Wong, Scott, Xia, Zongqi, Xiong, Xin, Ye, Ye, Yehya, Nadir, Yuan, William, Zachariasse, Joany M., Zahner, Janet J., Zambelli, Alberto, Zhang, Harrison G., Zöller, Daniela, Zuccaro, Valentina, Zucco, Chiara, Li, Xiudi, Rofeberg, Valerie N., Elias, Matthew D., Laird-Gion, Jessica, and Newburger, Jane W.

Published
2023
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10. Characterization of long COVID temporal sub-phenotypes by distributed representation learning from electronic health record data: a cohort study

Author

Aaron, James R., Agapito, Giuseppe, Albayrak, Adem, Albi, Giuseppe, Alessiani, Mario, Alloni, Anna, Amendola, Danilo F., François Angoulvant, Anthony, Li L.L.J., Aronow, Bruce J., Ashraf, Fatima, Atz, Andrew, Avillach, Paul, Azevedo, Paula S., Balshi, James, Beaulieu-Jones, Brett K., Bell, Douglas S., Bellasi, Antonio, Bellazzi, Riccardo, Benoit, Vincent, Beraghi, Michele, Bernal-Sobrino, José Luis, Bernaux, Mélodie, Bey, Romain, Bhatnagar, Surbhi, Blanco-Martínez, Alvar, Bonzel, Clara-Lea, Booth, John, Bosari, Silvano, Bourgeois, Florence T., Bradford, Robert L., Brat, Gabriel A., Bréant, Stéphane, Brown, Nicholas W., Bruno, Raffaele, Bryant, William A., Bucalo, Mauro, Bucholz, Emily, Burgun, Anita, Cai, Tianxi, Cannataro, Mario, Carmona, Aldo, Caucheteux, Charlotte, Champ, Julien, Chen, Jin, Chen, Krista Y., Chiovato, Luca, Chiudinelli, Lorenzo, Cho, Kelly, Cimino, James J., Colicchio, Tiago K., Cormont, Sylvie, Cossin, Sébastien, Craig, Jean B., Cruz-Bermúdez, Juan Luis, Cruz-Rojo, Jaime, Dagliati, Arianna, Daniar, Mohamad, Daniel, Christel, Das, Priyam, Devkota, Batsal, Dionne, Audrey, Duan, Rui, Dubiel, Julien, DuVall, Scott L., Esteve, Loic, Estiri, Hossein, Fan, Shirley, Follett, Robert W., Ganslandt, Thomas, Barrio, Noelia García, Garmire, Lana X., Gehlenborg, Nils, Getzen, Emily J., Geva, Alon, Gradinger, Tobias, Gramfort, Alexandre, Griffier, Romain, Griffon, Nicolas, Grisel, Olivier, Gutiérrez-Sacristán, Alba, Han, Larry, Hanauer, David A., Haverkamp, Christian, Hazard, Derek Y., He, Bing, Henderson, Darren W., Hilka, Martin, Ho, Yuk-Lam, Holmes, John H., Hong, Chuan, Huling, Kenneth M., Hutch, Meghan R., Issitt, Richard W., Jannot, Anne Sophie, Jouhet, Vianney, Kavuluru, Ramakanth, Keller, Mark S., Kennedy, Chris J., Key, Daniel A., Kirchoff, Katie, Klann, Jeffrey G., Kohane, Isaac S., Krantz, Ian D., Kraska, Detlef, Krishnamurthy, Ashok K., L'Yi, Sehi, Le, Trang T., Leblanc, Judith, Lemaitre, Guillaume, Lenert, Leslie, Leprovost, Damien, Liu, Molei, Will Loh, Ne Hooi, Long, Qi, Lozano-Zahonero, Sara, Luo, Yuan, Lynch, Kristine E., Mahmood, Sadiqa, Maidlow, Sarah E., Makoudjou, Adeline, Malovini, Alberto, Mandl, Kenneth D., Mao, Chengsheng, Maram, Anupama, Martel, Patricia, Martins, Marcelo R., Marwaha, Jayson S., Masino, Aaron J., Mazzitelli, Maria, Mensch, Arthur, Milano, Marianna, Minicucci, Marcos F., Moal, Bertrand, Ahooyi, Taha Mohseni, Moore, Jason H., Moraleda, Cinta, Morris, Jeffrey S., Morris, Michele, Moshal, Karyn L., Mousavi, Sajad, Mowery, Danielle L., Murad, Douglas A., Murphy, Shawn N., Naughton, Thomas P., Breda Neto, Carlos Tadeu, Neuraz, Antoine, Newburger, Jane, Ngiam, Kee Yuan, Njoroge, Wanjiku F.M., Norman, James B., Obeid, Jihad, Okoshi, Marina P., Olson, Karen L., Omenn, Gilbert S., Orlova, Nina, Ostasiewski, Brian D., Palmer, Nathan P., Paris, Nicolas, Patel, Lav P., Pedrera-Jiménez, Miguel, Pfaff, Emily R., Pfaff, Ashley C., Pillion, Danielle, Pizzimenti, Sara, Prokosch, Hans U., Prudente, Robson A., Prunotto, Andrea, Quirós-González, Víctor, Ramoni, Rachel B., Raskin, Maryna, Rieg, Siegbert, Roig-Domínguez, Gustavo, Rojo, Pablo, Rubio-Mayo, Paula, Sacchi, Paolo, Sáez, Carlos, Salamanca, Elisa, Samayamuthu, Malarkodi Jebathilagam, Sanchez-Pinto, L. Nelson, Sandrin, Arnaud, Santhanam, Nandhini, Santos, Janaina C.C., Sanz Vidorreta, Fernando J., Savino, Maria, Schriver, Emily R., Schubert, Petra, Schuettler, Juergen, Scudeller, Luigia, Sebire, Neil J., Serrano-Balazote, Pablo, Serre, Patricia, Serret-Larmande, Arnaud, Shah, Mohsin, Hossein Abad, Zahra Shakeri, Silvio, Domenick, Sliz, Piotr, Son, Jiyeon, Sonday, Charles, South, Andrew M., Spiridou, Anastasia, Strasser, Zachary H., Tan, Amelia L.M., Tan, Bryce W.Q., Tan, Byorn W.L., Tanni, Suzana E., Taylor, Deanne M., Terriza-Torres, Ana I., Tibollo, Valentina, Tippmann, Patric, Toh, Emma M.S., Torti, Carlo, Trecarichi, Enrico M., Tseng, Yi-Ju, Vallejos, Andrew K., Varoquaux, Gael, Vella, Margaret E., Verdy, Guillaume, Vie, Jill-Jênn, Visweswaran, Shyam, Vitacca, Michele, Wagholikar, Kavishwar B., Waitman, Lemuel R., Wang, Xuan, Wassermann, Demian, Weber, Griffin M., Wolkewitz, Martin, Wong, Scott, Xia, Zongqi, Xiong, Xin, Ye, Ye, Yehya, Nadir, Yuan, William, Zambelli, Alberto, Zhang, Harrison G., Zo¨ller, Daniela, Zuccaro, Valentina, Zucco, Chiara, Mesa, Rebecca, and Verdy, Guillame

Published
2023
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11. Treatments for multi-system inflammatory syndrome in children — discharge, fever, and second-line therapies

Author

Tagarro, Alfredo, Domínguez-Rodríguez, Sara, Mesa, Juan Miguel, Epalza, Cristina, Grasa, Carlos, Iglesias-Bouzas, María Isabel, Fernández-Cooke, Elisa, Calvo, Cristina, Villaverde, Serena, Torres-Fernández, David, Méndez-Echevarria, Ana, Leoz, Inés, Fernández-Pascual, María, Saavedra-Lozano, Jesús, Soto, Beatriz, Aguilera-Alonso, David, Rivière, Jacques G., Fumadó, Victoria, Martínez-Campos, Leticia, Vivanco, Ana, Pilar-Orive, Francisco Javier, Alcalá, Pedro, Ruiz, Beatriz, López-Machín, Ana, Oltra, Manuel, and Moraleda, Cinta

Published
2023
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14. Clinical spectrum of COVID-19 and risk factors associated with severity in Spanish children

Author

Tagarro, Alfredo, Cobos-Carrascosa, Elena, Villaverde, Serena, Sanz-Santaeufemia, Francisco-Javier, Grasa, Carlos, Soriano-Arandes, Antoni, Hernanz, Alicia, Navarro, María Luisa, Pino, Rosa, Epalza, Cristina, Batista, Rosa, Rizo, Jana, Iglesias-Bouzas, María-Isabel, Rodríguez-Molino, Paula, Villanueva-Medina, Sara, Carrasco-Colom, Jaime, Alonso-Cadenas, José-Antonio, Mellado, María-José, Herrero, Blanca, Melendo, Susana, De La Torre, Mercedes, Calleja, Lourdes, Calvo, Cristina, Urretavizcaya-Martínez, María, Astigarraga, Itziar, Menasalvas, Ana, Penin, María, Neth, Olaf, Berzosa, Arantxa, De Ceano-Vivas, María, Vidal, Paula, Romero, Isabel, González, Raúl, García, María Luz, Mesa, Juan-Miguel, Ballesteros, Álvaro, Bernardino, María, and Moraleda, Cinta

Published
2022
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16. Global burden of acute lower respiratory infection associated with human parainfluenza virus in children younger than 5 years for 2018: a systematic review and meta-analysis

Author

Wang, Xin, Li, You, Deloria-Knoll, Maria, Madhi, Shabir A, Cohen, Cheryl, Arguelles, Vina Lea, Basnet, Sudha, Bassat, Quique, Brooks, W Abdullah, Echavarria, Marcela, Fasce, Rodrigo A, Gentile, Angela, Goswami, Doli, Homaira, Nusrat, Howie, Stephen R C, Kotloff, Karen L, Khuri-Bulos, Najwa, Krishnan, Anand, Lucero, Marilla G, Lupisan, Socorro, Mathisen, Maria, McLean, Kenneth A, Mira-Iglesias, Ainara, Moraleda, Cinta, Okamoto, Michiko, Oshitani, Histoshi, O'Brien, Katherine L, Owor, Betty E, Rasmussen, Zeba A, Rath, Barbara A, Salimi, Vahid, Sawatwong, Pongpun, Scott, J Anthony G, Simões, Eric A F, Sotomayor, Viviana, Thea, Donald M, Treurnicht, Florette K, Yoshida, Lay-Myint, Zar, Heather J, Campbell, Harry, and Nair, Harish

Published
2021
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17. Fever without source as the first manifestation of SARS-CoV-2 infection in infants less than 90 days old

Author

Blázquez-Gamero, Daniel, Epalza, Cristina, Cadenas, José Antonio Alonso, Gero, Lourdes Calleja, Calvo, Cristina, Rodríguez-Molino, Paula, Méndez, María, Santos, Maria del Mar, Fumadó, Victoria, Guzmán, María Fernanda, Soriano-Arandes, Antoni, Jiménez, Ana B., Penin, Maria, Cobo-Vazquez, Elvira, Pareja, Marta, Lobato, Zulema, Serna, Miquel, Delgado, Rafael, Moraleda, Cinta, and Tagarro, Alfredo

Published
2021
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18. Global burden of acute lower respiratory infection associated with human metapneumovirus in children under 5 years in 2018: a systematic review and modelling study

Author

Libster, Romina, Otieno, Grieven, Joundi, Imane, Broor, Shobha, Nicol, Mark, Amarchand, Ritvik, Shi, Ting, López-Labrador, F. Xavier, Baker, Julia M., Jamison, Alexandra, Choudekar, Avinash, Juvekar, Sanjay, Obermeier, Patrick, Schweiger, Brunhilde, Madrid, Lola, Thomas, Elizabeth, Lanaspa, Miguel, Nohynek, Hanna, Nokes, James, Werner, Marta, Danhg, Anh, Chadha, Mandeep, Puig-Barberà, Joan, Caballero, Mauricio T., Mathisen, Maria, Walaza, Sibongile, Hellferscee, Orienka, Laubscher, Matt, Higdon, Melissa M., Haddix, Meredith, Sawatwong, Pongpun, Baggett, Henry C., Seidenberg, Phil, Mwanayanda, Lawrence, Antonio, Martin, Ebruke, Bernard E., Adams, Tanja, Rahman, Mustafizur, Rahman, Mohammed Ziaur, Sow, Samboa O., Baillie, Vicky L., Workman, Lesley, Toizumi, Michiko, Tapia, Milagritos D., Nguyen, Thi hien anh, Morpeth, Susan, Wang, Xin, Li, You, Deloria-Knoll, Maria, Madhi, Shabir A, Cohen, Cheryl, Ali, Asad, Basnet, Sudha, Bassat, Quique, Brooks, W Abdullah, Chittaganpitch, Malinee, Echavarria, Marcela, Fasce, Rodrigo A, Goswami, Doli, Hirve, Siddhivinayak, Homaira, Nusrat, Howie, Stephen R C, Kotloff, Karen L, Khuri-Bulos, Najwa, Krishnan, Anand, Lucero, Marilla G, Lupisan, Socorro, Mira-Iglesias, Ainara, Moore, David P, Moraleda, Cinta, Nunes, Marta, Oshitani, Histoshi, Owor, Betty E, Polack, Fernando P, O'Brien, Katherine L, Rasmussen, Zeba A, Rath, Barbara A, Salimi, Vahid, Scott, J Anthony G, Simões, Eric A F, Strand, Tor A, Thea, Donald M, Treurnicht, Florette K, Vaccari, Linda C, Yoshida, Lay-Myint, Zar, Heather J, Campbell, Harry, and Nair, Harish

Published
2021
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19. Cancer is not a risk factor for severe COVID‐19 in children, except in patients with recent allogeneic hematopoietic stem cell transplantation or comorbidities.

Author

Velasco Puyó, Pablo, Tagarro, Alfredo, Garcia‐Obregon, Susana, Villate, Olatz, Moraleda, Cinta, Huerta Aragonés, Jorge, Bardón Cancho, Eduardo J., Faura Morros, Anna, Galán‐Gómez, Víctor, Escobar Fernández, Laura, Lendinez‐Molinos, Francisco, Herrero Velasco, Blanca, Ureña Horno, Laura, Domínguez‐Pinilla, Nerea, Pascual Gazquez, Juan Francisco, Nova Lozano, Cristina, Osuna‐Marco, Marta, Marín‐Cruz, Inés, Gomez Pastrana, Irene, and Garcia de Andoin Barandiaran, Nagore

Published
2024
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21. Quality of care and maternal mortality in a tertiary-level hospital in Mozambique: a retrospective study of clinicopathological discrepancies

Author

Menéndez, Clara, Quintó, Llorenç, Castillo, Paola, Fernandes, Fabiola, Carrilho, Carla, Ismail, Mamudo R, Lorenzoni, Cesaltina, Hurtado, Juan Carlos, Rakislova, Natalia, Munguambe, Khátia, Moraleda, Cinta, Maixenchs, Maria, Macete, Eusebio, Mandomando, Inacio, Martínez, Miguel J, Alonso, Pedro L, Bassat, Quique, and Ordi, Jaume

Published
2020
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22. Global patterns in monthly activity of influenza virus, respiratory syncytial virus, parainfluenza virus, and metapneumovirus: a systematic analysis

Author

Acacio, Sozinho, Alonso, Wladimir J, Antonio, Martin, Ayora Talavera, Guadalupe, Badarch, Darmaa, Baillie, Vicky L, Barrera-Badillo, Gisela, Bigogo, Godfrey, Broor, Shobha, Bruden, Dana, Buchy, Philippe, Byass, Peter, Chipeta, James, Clara, Wilfrido, Dang, Duc-Anh, de Freitas Lázaro Emediato, Carla Cecília, de Jong, Menno, Díaz-Quiñonez, José Alberto, Do, Lien Anh Ha, Fasce, Rodrigo A, Feng, Luzhao, Ferson, Mark J, Gentile, Angela, Gessner, Bradford D, Goswami, Doli, Goyet, Sophie, Grijalva, Carlos G, Halasa, Natasha, Hellferscee, Orienka, Hessong, Danielle, Homaira, Nusrat, Jara, Jorge, Kahn, Kathleen, Khuri-Bulos, Najwa, Kotloff, Karen L, Lanata, Claudio F, Lopez, Olga, Lopez Bolaños, Maria Renee, Lucero, Marilla G, Lucion, Florencia, Lupisan, Socorro P, Madhi, Shabir A, Mekgoe, Omphile, Moraleda, Cinta, Moyes, Jocelyn, Mulholland, Kim, Munywoki, Patrick K, Naby, Fathima, Nguyen, Thanh Hung, Nicol, Mark P, Nokes, D James, Noyola, Daniel E, Onozuka, Daisuke, Palani, Nandhini, Poovorawan, Yong, Rahman, Mustafizur, Ramaekers, Kaat, Romero, Candice, Schlaudecker, Elizabeth P, Schweiger, Brunhilde, Seidenberg, Phil, Simoes, Eric A F, Singleton, Rosalyn, Sistla, Sujatha, Sturm-Ramirez, Katharine, Suntronwong, Nungruthai, Sutanto, Agustinus, Tapia, Milagritos D, Thamthitiwat, Somsak, Thongpan, Ilada, Tillekeratne, Gayani, Tinoco, Yeny O, Treurnicht, Florette K, Turner, Claudia, Turner, Paul, van Doorn, Rogier, Van Ranst, Marc, Visseaux, Benoit, Waicharoen, Sunthareeya, Wang, Jianwei, Yoshida, Lay-Myint, Zar, Heather J, Li, You, Reeves, Rachel M, Wang, Xin, Bassat, Quique, Brooks, W Abdullah, Cohen, Cheryl, Moore, David P, Nunes, Marta, Rath, Barbara, Campbell, Harry, and Nair, Harish

Published
2019
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24. PA-455 Bedside ultrasound for the diagnosis of tuberculosis in HIV-positive infants hospitalized with severe pneumonia

Author

Sidat, Muhammad, primary, Muvale, Gil, additional, Salgado, Mohammad, additional, Domingos, Cátia, additional, Liasse, Suraia, additional, Cassia, Uneisse, additional, Mavume, Celda, additional, Sacarlal, Jahit, additional, Passanduca, Alfeu, additional, Seni, Amir, additional, Chhaganlal, Kajal, additional, Borrell, Joseph, additional, Richardson, Shannon, additional, Lopez, Elisa, additional, Marcy, Olivier, additional, Ballesteros, Álvaro, additional, Tagarro, Alfredo, additional, Moraleda, Cinta, additional, Rojo, Pablo, additional, and Chris Buck, W, additional

Published
2023
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25. PA-450 Laboratory diagnosis of Pneumocystis jirovecii in HIV-positive infants with severe pneumonia using non-invasive samples

Author

Passanduca, Alfeu, primary, Nkongho, Franklyn, additional, Cassia, Uneisse, additional, Sidat, Muhammad, additional, Martins, Sónia, additional, Manjate, Elias, additional, Mavume, Celda, additional, Seni, Amir, additional, Chhaganlal, Kajal, additional, Salimo, Atija, additional, Gafur, Merunissa, additional, Beca, Laize, additional, Saide, Armando, additional, Borrell, Joseph, additional, Richardson, Shannon, additional, Nielsen-Saines, Karin, additional, Bramugy, Justina, additional, Fernández-Luis, Sheila, additional, Bassat, Quique, additional, Bates, Matthew, additional, Tagarro, Alfredo, additional, Moraleda, Cinta, additional, Rojo, Pablo, additional, Sacarlal, Jahit, additional, and Chris Buck, W, additional

Published
2023
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26. PA-655 Severe pneumonia is associated with worse neurocognitive function among infants living with HIV

Author

Nalwanga, Damalie, primary, Moraleda, Cinta, additional, Tagoola, Abner, additional, Lubega, John Paul, additional, Nalunkuma, Amina, additional, Kakooza, Lawrence, additional, Kiggwe, Andrew, additional, Mbabazi, Bashira, additional, Nkinzi, Sharafat, additional, Ballesteros, Alvaro, additional, Tagarro, Alfredo, additional, Rojo, Pablo, additional, and Musiime, Victor, additional

Published
2023
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27. PA-477 Building a national network for inpatient pediatric clinical research in Mozambique

Author

Sacarlal, Jahit, primary, Chris Buck, W, additional, Passanduca, Alfeu, additional, Macassa, Eugénia, additional, Saíde, Alarquia, additional, Chhaganlal, Kajal, additional, Gafur, Merunissa, additional, Seni, Amir, additional, Machava, Sara, additional, Martins, Luzidina, additional, Issa, Faiaz, additional, Macanze, Eleutéria, additional, Manjate, Nádia, additional, Chaúque, Sílvia, additional, Langa, Stella, additional, Sidat, Muhammad, additional, Cassia, Uneisse, additional, Salimo, Atija, additional, Mavume, Celda, additional, Massitela, Cláudia, additional, Maieca, Alice, additional, Joaquim, Winete, additional, Martins, Sónia, additional, Adriano, Quim, additional, Zandamela, Mastalina, additional, Bramugy, Justina, additional, Bassat, Quique, additional, Moraleda, Cinta, additional, Tagarro, Alfredo, additional, Sharland, Mike, additional, and Rojo, Pablo, additional

Published
2023
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28. OA-429 High mortality in African infants living with HIV hospitalized with severe pneumonia

Author

Nduna, Bwendo, primary, Moraleda, Cinta, additional, Sacaral, Jahit, additional, Beinomugisha, Judith, additional, Zulu, Idah, additional, Chitamatanga, Moses, additional, Tam, Pui-Ying Iroh, additional, Chawinga, Chimwemwe, additional, Fernandez, Sheila, additional, Ballesteros, Álvaro, additional, Passanduca, Alfeu, additional, Tagoola, Abner, additional, Atibo, Raul, additional, Nansera, Denis, additional, Bwakura-Dangarembizi, Mutsa, additional, Gambi, Lughano, additional, Mvalo, Tisungane, additional, Madrid, Lola, additional, Macmillan, Belinda, additional, Musiime, Victor, additional, Moh, Raoul, additional, Buck, Chris W, additional, Chabala, Chishala, additional, Tagarro, Alfredo, additional, Rojo, Pablo, additional, and Empirical, Trial, additional

Published
2023
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29. OA-286 Plasma concentrations of first line antituberculosis drugs in infants with HIV and severe pneumonia: a pharmacokinetic sub-study of the empirical trial

Author

Chabala, Chishala, primary, Jacobs, Tom, additional, Moraleda, Cinta, additional, Mumbiro, Vivian, additional, Namuziya, Natasha, additional, Mutesi, Sophie, additional, Domínguez-Rodríguez, Sara, additional, Chitsamatanga, Moses, additional, Casia, Uneisse, additional, Nalwanga, Damalie, additional, Nduna, Bwendo, additional, Lajara, Nancy, additional, Ballesteros, Alvaro, additional, Madrid, Lola, additional, Nathoo, Kusum, additional, Mulenga, Veronica, additional, Buck, Chris, additional, Musiime, Victor, additional, Mujuru, Hilda, additional, Tagarro, Alfredo, additional, Brake, Lindsey te, additional, Aarnoutse, Rob, additional, Rojo, Pablo, additional, and Burger, David, additional

Published
2023
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30. Clinical phenotypes and outcomes in children with multisystem inflammatory syndrome across SARS-CoV-2 variant eras: a multinational study from the 4CE consortium

Author

Sperotto, Francesca, primary, Gutiérrez-Sacristán, Alba, additional, Makwana, Simran, additional, Li, Xiudi, additional, Rofeberg, Valerie N., additional, Cai, Tianxi, additional, Bourgeois, Florence T., additional, Omenn, Gilbert S., additional, Hanauer, David A., additional, Sáez, Carlos, additional, Bonzel, Clara-Lea, additional, Bucholz, Emily, additional, Dionne, Audrey, additional, Elias, Matthew D., additional, García-Barrio, Noelia, additional, González, Tomás González, additional, Issitt, Richard W., additional, Kernan, Kate F., additional, Laird-Gion, Jessica, additional, Maidlow, Sarah E., additional, Mandl, Kenneth D., additional, Ahooyi, Taha Mohseni, additional, Moraleda, Cinta, additional, Morris, Michele, additional, Moshal, Karyn L., additional, Pedrera-Jiménez, Miguel, additional, Shah, Mohsin A., additional, South, Andrew M., additional, Spiridou, Anastasia, additional, Taylor, Deanne M., additional, Verdy, Guillaume, additional, Visweswaran, Shyam, additional, Wang, Xuan, additional, Xia, Zongqi, additional, Zachariasse, Joany M., additional, Newburger, Jane W., additional, Avillach, Paul, additional, Aaron, James R., additional, Adam, Atif, additional, Agapito, Giuseppe, additional, Albayrak, Adem, additional, Albi, Giuseppe, additional, Alessiani, Mario, additional, Alloni, Anna, additional, Amendola, Danilo F., additional, Angoulvant, François, additional, Anthony, Li LLJ., additional, Aronow, Bruce J., additional, Ashraf, Fatima, additional, Atz, Andrew, additional, Panickan, Vidul Ayakulangara, additional, Azevedo, Paula S., additional, Badenes, Rafael, additional, Balshi, James, additional, Batugo, Ashley, additional, Beaulieu-Jones, Brendin R., additional, Beaulieu-Jones, Brett K., additional, Bell, Douglas S., additional, Bellasi, Antonio, additional, Bellazzi, Riccardo, additional, Benoit, Vincent, additional, Beraghi, Michele, additional, Bernal-Sobrino, José Luis, additional, Bernaux, Mélodie, additional, Bey, Romain, additional, Bhatnagar, Surbhi, additional, Blanco-Martínez, Alvar, additional, Boeker, Martin, additional, Booth, John, additional, Bosari, Silvano, additional, Bradford, Robert L., additional, Brat, Gabriel A., additional, Bréant, Stéphane, additional, Brown, Nicholas W., additional, Bruno, Raffaele, additional, Bryant, William A., additional, Bucalo, Mauro, additional, Burgun, Anita, additional, Cannataro, Mario, additional, Carmona, Aldo, additional, Cattelan, Anna Maria, additional, Caucheteux, Charlotte, additional, Champ, Julien, additional, Chen, Jin, additional, Chen, Krista Y., additional, Chiovato, Luca, additional, Chiudinelli, Lorenzo, additional, Cho, Kelly, additional, Cimino, James J., additional, Colicchio, Tiago K., additional, Cormont, Sylvie, additional, Cossin, Sébastien, additional, Craig, Jean B., additional, Cruz-Bermúdez, Juan Luis, additional, Cruz-Rojo, Jaime, additional, Dagliati, Arianna, additional, Daniar, Mohamad, additional, Daniel, Christel, additional, Das, Priyam, additional, Devkota, Batsal, additional, Duan, Rui, additional, Dubiel, Julien, additional, DuVall, Scott L., additional, Esteve, Loic, additional, Estiri, Hossein, additional, Fan, Shirley, additional, Follett, Robert W., additional, Ganslandt, Thomas, additional, Garmire, Lana X., additional, Gehlenborg, Nils, additional, Getzen, Emily J., additional, Geva, Alon, additional, Goh, Rachel SJ., additional, Gradinger, Tobias, additional, Gramfort, Alexandre, additional, Griffier, Romain, additional, Griffon, Nicolas, additional, Grisel, Olivier, additional, Guzzi, Pietro H., additional, Han, Larry, additional, Haverkamp, Christian, additional, Hazard, Derek Y., additional, He, Bing, additional, Henderson, Darren W., additional, Hilka, Martin, additional, Ho, Yuk-Lam, additional, Holmes, John H., additional, Honerlaw, Jacqueline P., additional, Hong, Chuan, additional, Huling, Kenneth M., additional, Hutch, Meghan R., additional, Jannot, Anne Sophie, additional, Jouhet, Vianney, additional, Kainth, Mundeep K., additional, Kate, Kernan F., additional, Kavuluru, Ramakanth, additional, Keller, Mark S., additional, Kennedy, Chris J., additional, Key, Daniel A., additional, Kirchoff, Katie, additional, Klann, Jeffrey G., additional, Kohane, Isaac S., additional, Krantz, Ian D., additional, Kraska, Detlef, additional, Krishnamurthy, Ashok K., additional, L'Yi, Sehi, additional, Leblanc, Judith, additional, Lemaitre, Guillaume, additional, Lenert, Leslie, additional, Leprovost, Damien, additional, Liu, Molei, additional, Will Loh, Ne Hooi, additional, Long, Qi, additional, Lozano-Zahonero, Sara, additional, Luo, Yuan, additional, Lynch, Kristine E., additional, Mahmood, Sadiqa, additional, Makoudjou, Adeline, additional, Malovini, Alberto, additional, Mao, Chengsheng, additional, Maram, Anupama, additional, Maripuri, Monika, additional, Martel, Patricia, additional, Martins, Marcelo R., additional, Marwaha, Jayson S., additional, Masino, Aaron J., additional, Mazzitelli, Maria, additional, Mazzotti, Diego R., additional, Mensch, Arthur, additional, Milano, Marianna, additional, Minicucci, Marcos F., additional, Moal, Bertrand, additional, Moore, Jason H., additional, Morris, Jeffrey S., additional, Mousavi, Sajad, additional, Mowery, Danielle L., additional, Murad, Douglas A., additional, Murphy, Shawn N., additional, Naughton, Thomas P., additional, Breda Neto, Carlos Tadeu, additional, Neuraz, Antoine, additional, Newburger, Jane, additional, Ngiam, Kee Yuan, additional, Njoroge, Wanjiku FM., additional, Norman, James B., additional, Obeid, Jihad, additional, Okoshi, Marina P., additional, Olson, Karen L., additional, Orlova, Nina, additional, Ostasiewski, Brian D., additional, Palmer, Nathan P., additional, Paris, Nicolas, additional, Patel, Lav P., additional, Pfaff, Ashley C., additional, Pfaff, Emily R., additional, Pillion, Danielle, additional, Pizzimenti, Sara, additional, Priya, Tanu, additional, Prokosch, Hans U., additional, Prudente, Robson A., additional, Prunotto, Andrea, additional, Quirós-González, Víctor, additional, Ramoni, Rachel B., additional, Raskin, Maryna, additional, Rieg, Siegbert, additional, Roig-Domínguez, Gustavo, additional, Rojo, Pablo, additional, Romero-Garcia, Nekane, additional, Rubio-Mayo, Paula, additional, Sacchi, Paolo, additional, Salamanca, Elisa, additional, Samayamuthu, Malarkodi Jebathilagam, additional, Sanchez-Pinto, L. Nelson, additional, Sandrin, Arnaud, additional, Santhanam, Nandhini, additional, Santos, Janaina C.C., additional, Sanz Vidorreta, Fernando J., additional, Savino, Maria, additional, Schriver, Emily R., additional, Schubert, Petra, additional, Schuettler, Juergen, additional, Scudeller, Luigia, additional, Sebire, Neil J., additional, Serrano-Balazote, Pablo, additional, Serre, Patricia, additional, Serret-Larmande, Arnaud, additional, Hossein Abad, Zahra Shakeri, additional, Silvio, Domenick, additional, Sliz, Piotr, additional, Son, Jiyeon, additional, Sonday, Charles, additional, Sperotto, Francesca, additional, Strasser, Zachary H., additional, Tan, Amelia LM., additional, Tan, Bryce W.Q., additional, Tan, Byorn W.L., additional, Tanni, Suzana E., additional, Terriza-Torres, Ana I., additional, Tibollo, Valentina, additional, Tippmann, Patric, additional, Toh, Emma MS., additional, Torti, Carlo, additional, Trecarichi, Enrico M., additional, Vallejos, Andrew K., additional, Varoquaux, Gael, additional, Vella, Margaret E., additional, Vie, Jill-Jênn, additional, Vitacca, Michele, additional, Wagholikar, Kavishwar B., additional, Waitman, Lemuel R., additional, Wassermann, Demian, additional, Weber, Griffin M., additional, Wolkewitz, Martin, additional, Wong, Scott, additional, Xiong, Xin, additional, Ye, Ye, additional, Yehya, Nadir, additional, Yuan, William, additional, Zahner, Janet J., additional, Zambelli, Alberto, additional, Zhang, Harrison G., additional, Zöller, Daniela, additional, Zuccaro, Valentina, additional, and Zucco, Chiara, additional

Published
2023
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31. MIS-C, Can Latency Interval Help in Diagnosis?

Author

Mosquera Fernández, Pablo, García García, Sonsoles, Epalza, Cristina, Blázquez-Gamero, Daniel, Carrasco, Jaime, Fernandez-Cook, Elisa, Prieto-Tato, Luis, Torres, David, Villaverde, Serena, Belda, Sylvia, Toral-Vázquez, Belén, and Moraleda, Cinta

Published
2021
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32. PHENOTYPIC VARIATION IN DISEASE SEVERITY AMONG HOSPITALIZED PEDIATRIC PATIENTS WITH COVID-19: ASSESSING THE IMPACT OF COVID-19 IN THE EPICO STUDY

Author

Vanegas, Melisa Sofía Naranjo, primary, Sossa, María Camila, additional, Gutiérrez, Mónica Paola, additional, Becerra, Natalia, additional, Ortegon, Luz Yessenia, additional, David, María Camila, additional, Vasquez-Hoyos, Pablo, additional, Mesa-Rubio, María Lucia, additional, Moreno-Lopez, Sergio, additional, Castañeda, Olga Lucía Baquero, additional, Restrepo-Gualteros, Sonia, additional, Galvis, Clara, additional, Africano, Martha, additional, MORALEDA, CINTA, additional, TAGARRO, ALFREDO, additional, Herrero, Blanca, additional, Grasa, Carlos, additional, Soriano-Arandes, Antoni, additional, Ramirez, Andrea, additional, Ramirez, Luis Miguel Navarro, additional, Friedrich, Gabriela, additional, Díaz-Díaz, Alejandro, additional, Alvarez-Moreno, Carlos, additional, Piñeros, Juan Gabriel, additional, Mejía, Luz Marina, additional, Gutierrez-Tobar, Iván, additional, Mesa, Andrés Camilo, additional, Tuta, William Ricardo Bachiller, additional, Nieto, José Manuel, additional, Camacho, Paola Marcela Pérez, additional, Beltrán-Arroyave, Claudia, additional, Trochez, Rosalba Vivas, additional, Gastegi, Irati, additional, Rodriguez-Molino, Paula, additional, Melendo, Susana, additional, Pastrana, Irene Gómez, additional, García, Sonsoles García, additional, Fumadó, Victoria, additional, and Calleja, Lourdes, additional

Published
2023
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33. WHAT TO LOOK FOR IN CHEST X-RAYS OF PEDIATRIC PATIENTS WITH COVID-19: INSIGHTS FROM A COLOMBIAN COHORT.

Author

Vanegas, Melisa Sofía Naranjo, primary, Burgos, Claudia, additional, Mendez, Laura Melissa, additional, Rodriguez, María Margarita, additional, Martinez, Arianna, additional, Sanchez, Paola, additional, Tovar, Carolina, additional, Vasquez-Hoyos, Pablo, additional, Mesa-Rubio, María Lucia, additional, Triana, Gustavo, additional, Royero-Arias, Mónica, additional, Echeverry, Jessica, additional, Gamo, Tamara, additional, Moreno, Luz Ángela, additional, Castañeda, Olga Lucía Baquero, additional, Restrepo-Gualteros, Sonia, additional, Moreno-Lopez, Sergio, additional, Galvis, Clara, additional, MORALEDA, CINTA, additional, TAGARRO, ALFREDO, additional, Ramirez, Andrea, additional, Friedrich, Gabriela, additional, Mejía, Luz Marina, additional, Ramirez, Luis Miguel Navarro, additional, Piñeros, Juan Gabriel, additional, Alvarez-Moreno, Carlos, additional, Díaz-Díaz, Alejandro, additional, Gutierrez-Tobar, Iván, additional, Nieto, José Manuel, additional, and Gastegi, Irati, additional

Published
2023
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34. Global, regional, and national disease burden estimates of acute lower respiratory infections due to respiratory syncytial virus in young children in 2015: a systematic review and modelling study

Author

Shi, Ting, McAllister, David A, O'Brien, Katherine L, Simoes, Eric A F, Madhi, Shabir A, Gessner, Bradford D, Polack, Fernando P, Balsells, Evelyn, Acacio, Sozinho, Aguayo, Claudia, Alassani, Issifou, Ali, Asad, Antonio, Martin, Awasthi, Shally, Awori, Juliet O, Azziz-Baumgartner, Eduardo, Baggett, Henry C, Baillie, Vicky L, Balmaseda, Angel, Barahona, Alfredo, Basnet, Sudha, Bassat, Quique, Basualdo, Wilma, Bigogo, Godfrey, Bont, Louis, Breiman, Robert F, Brooks, W Abdullah, Broor, Shobha, Bruce, Nigel, Bruden, Dana, Buchy, Philippe, Campbell, Stuart, Carosone-Link, Phyllis, Chadha, Mandeep, Chipeta, James, Chou, Monidarin, Clara, Wilfrido, Cohen, Cheryl, de Cuellar, Elizabeth, Dang, Duc-Anh, Dash-yandag, Budragchaagiin, Deloria-Knoll, Maria, Dherani, Mukesh, Eap, Tekchheng, Ebruke, Bernard E, Echavarria, Marcela, de Freitas Lázaro Emediato, Carla Cecília, Fasce, Rodrigo A, Feikin, Daniel R, Feng, Luzhao, Gentile, Angela, Gordon, Aubree, Goswami, Doli, Goyet, Sophie, Groome, Michelle, Halasa, Natasha, Hirve, Siddhivinayak, Homaira, Nusrat, Howie, Stephen R C, Jara, Jorge, Jroundi, Imane, Kartasasmita, Cissy B, Khuri-Bulos, Najwa, Kotloff, Karen L, Krishnan, Anand, Libster, Romina, Lopez, Olga, Lucero, Marilla G, Lucion, Florencia, Lupisan, Socorro P, Marcone, Debora N, McCracken, John P, Mejia, Mario, Moisi, Jennifer C, Montgomery, Joel M, Moore, David P, Moraleda, Cinta, Moyes, Jocelyn, Munywoki, Patrick, Mutyara, Kuswandewi, Nicol, Mark P, Nokes, D James, Nymadawa, Pagbajabyn, da Costa Oliveira, Maria Tereza, Oshitani, Histoshi, Pandey, Nitin, Paranhos-Baccalà, Gláucia, Phillips, Lia N, Picot, Valentina Sanchez, Rahman, Mustafizur, Rakoto-Andrianarivelo, Mala, Rasmussen, Zeba A, Rath, Barbara A, Robinson, Annick, Romero, Candice, Russomando, Graciela, Salimi, Vahid, Sawatwong, Pongpun, Scheltema, Nienke, Schweiger, Brunhilde, Scott, J Anthony G, Seidenberg, Phil, Shen, Kunling, Singleton, Rosalyn, Sotomayor, Viviana, Strand, Tor A, Sutanto, Agustinus, Sylla, Mariam, Tapia, Milagritos D, Thamthitiwat, Somsak, Thomas, Elizabeth D, Tokarz, Rafal, Turner, Claudia, Venter, Marietjie, Waicharoen, Sunthareeya, Wang, Jianwei, Watthanaworawit, Wanitda, Yoshida, Lay-Myint, Yu, Hongjie, Zar, Heather J, Campbell, Harry, and Nair, Harish

Published
2017
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36. Prevalence and Clinical Manifestations of Congenital Cytomegalovirus Infection in a Screening Program in Madrid (PICCSA Study)

Author

Blázquez-Gamero, Daniel, Soriano-Ramos, María, Vicente, Marta, Pallás-Alonso, Carmen Rosa, Pérez-Rivilla, Alfredo, García-Álvarez, Mónica, Pinilla Martín, María Teresa, Freire, Xavier, De Vergas, Joaquín, De Aragón, Ana Martínez, Zamora, Berta, Epalza, Cristina, Moraleda, Cinta, Rojo, Pablo, Prieto, Luis, Fernández-Cooke, Elisa, Ruíz-Contreras, Jesús, Delgado, Rafael, and Folgueira, María Dolores

Published
2020
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37. Oral saliva swab reverse transcription PCR for Covid-19 in the paediatric population

Author

Instituto de Salud Carlos III, Ministerio de Economía y Competitividad (España), European Commission, Asociación Española de Pediatría, Universidad Europea de Madrid, Ministerio de Ciencia e Innovación (España), Moraleda, Cinta [0000-0002-8335-903X], Domínguez-Rodríguez, Sara [0000-0003-3747-9265], Mesa, Juan Miguel [0000-0003-2338-7984], García Sánchez, Paula [0000-0003-4866-6656], Alonso-Cadenas, José Antonio [0000-0002-7648-1336], Bermejo, Amanda [0000-0002-1568-6805], Sabrido, Gema [0000-0002-9690-261X], Martínez-Campos, Leticia [0000-0002-1493-0060], Gonzlez-Posada, Aránzazu Flavia [0000-0001-5787-9093], Illán-Ramos, Marta [0000-0003-2491-1549], Cobos-Carrascosa, Elena [0000-0001-7553-9615], Aguilera-Alonso, David [0000-0003-1017-2386], Dahdouh, Elias [0000-0003-2309-4129], Blázquez-Gamero, Daniel [0000-0001-6483-8329], Gonzalez-Donapetry, Patricia [0000-0002-6093-3254], Fernández-Pinero, Jovita [0000-0001-9919-0112], Pérez-Ramírez, Elisa [0000-0001-7701-9816], Tagarro, Alfredo [0000-0003-2860-3455], Moraleda, Cinta, Domínguez-Rodríguez, Sara, Mesa, Juan Miguel, García Sánchez, Paula, de la Serna, María, Alonso-Cadenas, José Antonio, Bermejo, Amanda, Sabrido, Gema, Martínez-Campos, Leticia, González-Posada, Aránzazu Flavia, Illán-Ramos, Marta, Cobos-Carrascosa, Elena, Ballesteros, Álvaro, Galán, Juan Carlos, Llorente, Francisco, Aguilera-Alonso, David, Jiménez, Ana Belén, Catalán, Pilar, Dahdouh, Elias, Navarro, Ignacio, Fernández-Garoz, Bárbara, Mendoza, Pablo, Pérez-Jorge, Concepción, Cabezas-Fernández, Teresa, Blázquez-Gamero, Daniel, Rivas, Gonzalo, Gonzalez-Donapetry, Patricia, Sáez, Elena, Fernández-Pinero, Jovita, Lucas-Fernández, Jesús, Pérez-Ramírez, E., Merino, Paloma, Miragaya, Sandra, Lorente, Jorge, Iglesias, Irene, Tagarro, Alfredo, Instituto de Salud Carlos III, Ministerio de Economía y Competitividad (España), European Commission, Asociación Española de Pediatría, Universidad Europea de Madrid, Ministerio de Ciencia e Innovación (España), Moraleda, Cinta [0000-0002-8335-903X], Domínguez-Rodríguez, Sara [0000-0003-3747-9265], Mesa, Juan Miguel [0000-0003-2338-7984], García Sánchez, Paula [0000-0003-4866-6656], Alonso-Cadenas, José Antonio [0000-0002-7648-1336], Bermejo, Amanda [0000-0002-1568-6805], Sabrido, Gema [0000-0002-9690-261X], Martínez-Campos, Leticia [0000-0002-1493-0060], Gonzlez-Posada, Aránzazu Flavia [0000-0001-5787-9093], Illán-Ramos, Marta [0000-0003-2491-1549], Cobos-Carrascosa, Elena [0000-0001-7553-9615], Aguilera-Alonso, David [0000-0003-1017-2386], Dahdouh, Elias [0000-0003-2309-4129], Blázquez-Gamero, Daniel [0000-0001-6483-8329], Gonzalez-Donapetry, Patricia [0000-0002-6093-3254], Fernández-Pinero, Jovita [0000-0001-9919-0112], Pérez-Ramírez, Elisa [0000-0001-7701-9816], Tagarro, Alfredo [0000-0003-2860-3455], Moraleda, Cinta, Domínguez-Rodríguez, Sara, Mesa, Juan Miguel, García Sánchez, Paula, de la Serna, María, Alonso-Cadenas, José Antonio, Bermejo, Amanda, Sabrido, Gema, Martínez-Campos, Leticia, González-Posada, Aránzazu Flavia, Illán-Ramos, Marta, Cobos-Carrascosa, Elena, Ballesteros, Álvaro, Galán, Juan Carlos, Llorente, Francisco, Aguilera-Alonso, David, Jiménez, Ana Belén, Catalán, Pilar, Dahdouh, Elias, Navarro, Ignacio, Fernández-Garoz, Bárbara, Mendoza, Pablo, Pérez-Jorge, Concepción, Cabezas-Fernández, Teresa, Blázquez-Gamero, Daniel, Rivas, Gonzalo, Gonzalez-Donapetry, Patricia, Sáez, Elena, Fernández-Pinero, Jovita, Lucas-Fernández, Jesús, Pérez-Ramírez, E., Merino, Paloma, Miragaya, Sandra, Lorente, Jorge, Iglesias, Irene, and Tagarro, Alfredo

Abstract

To evaluate the performance of oral saliva swab (OSS) reverse transcription PCR (RT-PCR) compared with RT-PCR and antigen rapid diagnostic test (Ag-RDT) on nasopharyngeal swabs (NPS) for SARS-CoV-2 in children.

Published
2022

39. Oral saliva swab reverse transcription PCR for Covid-19 in the paediatric population

Author

Moraleda, Cinta, Domínguez-Rodríguez, Sara, Mesa, Juan Miguel, García-Sánchez, Paula, de la Serna, María, Alonso-Cadenas, José Antonio, Bermejo, Amanda, Sabrido, Gema, Martínez-Campos, Leticia, González-Posada, Aránzazu Flavia, Illán-Ramos, Marta, Cobos-Carrascosa, Elena, Ballesteros, Álvaro, Galán, Juan Carlos, Llorente, Francisco, Aguilera-Alonso, David, Jiménez, Ana Belén, Catalán, Pilar, Dahdouh, Elias, Navarro, Ignacio, Fernández-Garoz, Bárbara, Mendoza, Pablo, Pérez-Jorge, Concepción, Cabezas-Fernández, Teresa, Blázquez-Gamero, Daniel, Rivas, Gonzalo, Gonzalez-Donapetry, Patricia, Sáez, Elena, Fernández-Pinero, Jovita, Lucas-Fernández, Jesús, Pérez-Ramírez, Elisa, Merino, Paloma, Miragaya, Sandra, Lorente, Jorge, Iglesias, Irene, Tagarro, Alfredo, EPICO working group, Instituto de Salud Carlos III, Ministerio de Economía y Competitividad (España), European Commission, Asociación Española de Pediatría, Universidad Europea de Madrid, Ministerio de Ciencia e Innovación (España), Moraleda, Cinta, Domínguez-Rodríguez, Sara, Mesa, Juan Miguel, García-Sánchez, Paula, Alonso-Cadenas, José Antonio, Bermejo, Amanda, Sabrido, Gema, Martínez-Campos, Leticia, Gonzlez-Posada, Aránzazu Flavia, Illán-Ramos, Marta, Cobos-Carrascosa, Elena, Aguilera-Alonso, David, Dahdouh, Elias, Blázquez-Gamero, Daniel, Gonzalez-Donapetry, Patricia, Fernández-Pinero, Jovita, Pérez-Ramírez, Elisa, Tagarro, Alfredo, Moraleda, Cinta [0000-0002-8335-903X], Domínguez-Rodríguez, Sara [0000-0003-3747-9265], Mesa, Juan Miguel [0000-0003-2338-7984], García-Sánchez, Paula [0000-0003-4866-6656], Alonso-Cadenas, José Antonio [0000-0002-7648-1336], Bermejo, Amanda [0000-0002-1568-6805], Sabrido, Gema [0000-0002-9690-261X], Martínez-Campos, Leticia [0000-0002-1493-0060], Gonzlez-Posada, Aránzazu Flavia [0000-0001-5787-9093], Illán-Ramos, Marta [0000-0003-2491-1549], Cobos-Carrascosa, Elena [0000-0001-7553-9615], Aguilera-Alonso, David [0000-0003-1017-2386], Dahdouh, Elias [0000-0003-2309-4129], Blázquez-Gamero, Daniel [0000-0001-6483-8329], Gonzalez-Donapetry, Patricia [0000-0002-6093-3254], Fernández-Pinero, Jovita [0000-0001-9919-0112], Pérez-Ramírez, Elisa [0000-0001-7701-9816], and Tagarro, Alfredo [0000-0003-2860-3455]

Subjects
Infectious Disease Medicine, SARS-CoV-2, Infecciones por coronavirus, Pediatría, COVID-19, Enfermedad transmisible, Reverse Transcription, Sensitivity and Specificity, Polymerase Chain Reaction, Microbiology, Ensayo, COVID-19 Testing, Cross-Sectional Studies, Virology, Pediatrics, Perinatology and Child Health, Humans, Prospective Studies, Child, Saliva, Molecular Biology
Abstract

8Pág. Centro de Investigación en Sanidad Animal (CISA), To evaluate the performance of oral saliva swab (OSS) reverse transcription PCR (RT-PCR) compared with RT-PCR and antigen rapid diagnostic test (Ag-RDT) on nasopharyngeal swabs (NPS) for SARS-CoV-2 in children., The study was funded by: Project PI20/00095, from the Instituto de Salud Carlos III (Ministry of Economy, Industry and Competitiveness) and cofounded by the European Regional Development Fund, by Infanta Sofia University Hospital and Henares University Hospital Foundation for Biomedical Research and Innovation (FIIB HUIS HHEN), and by SERMAS-Fundación para la Investigación Biomédica del Hospital 12 de Octubre. EC-C is supported by the Spanish Society of Paediatrics (Asociación Española de Pediatría); Grant COVID-19 EPICO-AEP 2020. JMM is funded by SERMAS-Fundación para la Investigación Biomédica del Hospital Infanta Sofía y del Henares and by Universidad Europea de Madrid, Spain. MdlS is funded by Grant Cantera de Investigación Santander, Fundación Universidad Europea de Madrid, Spain. ED is funded by the Juan de la Cierva–Incorporación granted by the Spanish Ministry of Science and Innovation. DB-G is funded by the Spanish Ministry of Science and Innovation—Instituto de Salud Carlos III and Fondos FEDER by ’Contratos para la intensificación de la actividad investigadora en el Sistema Nacional de Salud, 2020 (INT20/00086)’.

Published
2022

43. Long-term kidney function recovery and mortality after COVID-19-associated acute kidney injury: an international multi-centre observational cohort study

Author

Tan, Byorn W.L., primary, Tan, Bryce W.Q., additional, Tan, Amelia L.M., additional, Schriver, Emily R., additional, Gutiérrez-Sacristán, Alba, additional, Das, Priyam, additional, Yuan, William, additional, Hutch, Meghan R., additional, García Barrio, Noelia, additional, Pedrera Jimenez, Miguel, additional, Abu-el-rub, Noor, additional, Morris, Michele, additional, Moal, Bertrand, additional, Verdy, Guillaume, additional, Cho, Kelly, additional, Ho, Yuk-Lam, additional, Patel, Lav P., additional, Dagliati, Arianna, additional, Neuraz, Antoine, additional, Klann, Jeffrey G., additional, South, Andrew M., additional, Visweswaran, Shyam, additional, Hanauer, David A., additional, Maidlow, Sarah E., additional, Liu, Mei, additional, Mowery, Danielle L., additional, Batugo, Ashley, additional, Makoudjou, Adeline, additional, Tippmann, Patric, additional, Zöller, Daniela, additional, Brat, Gabriel A., additional, Luo, Yuan, additional, Avillach, Paul, additional, Bellazzi, Riccardo, additional, Chiovato, Luca, additional, Malovini, Alberto, additional, Tibollo, Valentina, additional, Samayamuthu, Malarkodi Jebathilagam, additional, Serrano Balazote, Pablo, additional, Xia, Zongqi, additional, Loh, Ne Hooi Will, additional, Chiudinelli, Lorenzo, additional, Bonzel, Clara-Lea, additional, Hong, Chuan, additional, Zhang, Harrison G., additional, Weber, Griffin M., additional, Kohane, Isaac S., additional, Cai, Tianxi, additional, Omenn, Gilbert S., additional, Holmes, John H., additional, Ngiam, Kee Yuan, additional, Aaron, James R., additional, Agapito, Giuseppe, additional, Albayrak, Adem, additional, Albi, Giuseppe, additional, Alessiani, Mario, additional, Alloni, Anna, additional, Amendola, Danilo F., additional, Angoulvant, François, additional, Anthony, Li L.L.J., additional, Aronow, Bruce J., additional, Ashraf, Fatima, additional, Atz, Andrew, additional, Panickan, Vidul Ayakulangara, additional, Azevedo, Paula S., additional, Balshi, James, additional, Beaulieu-Jones, Brett K., additional, Beaulieu-Jones, Brendin R., additional, Bell, Douglas S., additional, Bellasi, Antonio, additional, Benoit, Vincent, additional, Beraghi, Michele, additional, Bernal-Sobrino, José Luis, additional, Bernaux, Mélodie, additional, Bey, Romain, additional, Bhatnagar, Surbhi, additional, Blanco-Martínez, Alvar, additional, Boeker, Martin, additional, Booth, John, additional, Bosari, Silvano, additional, Bourgeois, Florence T., additional, Bradford, Robert L., additional, Bréant, Stéphane, additional, Brown, Nicholas W., additional, Bruno, Raffaele, additional, Bryant, William A., additional, Bucalo, Mauro, additional, Bucholz, Emily, additional, Burgun, Anita, additional, Cannataro, Mario, additional, Carmona, Aldo, additional, Cattelan, Anna Maria, additional, Caucheteux, Charlotte, additional, Champ, Julien, additional, Chen, Jin, additional, Chen, Krista Y., additional, Cimino, James J., additional, Colicchio, Tiago K., additional, Cormont, Sylvie, additional, Cossin, Sébastien, additional, Craig, Jean B., additional, Cruz-Bermúdez, Juan Luis, additional, Cruz-Rojo, Jaime, additional, Daniar, Mohamad, additional, Daniel, Christel, additional, Devkota, Batsal, additional, Dionne, Audrey, additional, Duan, Rui, additional, Dubiel, Julien, additional, DuVall, Scott L., additional, Esteve, Loic, additional, Estiri, Hossein, additional, Fan, Shirley, additional, Follett, Robert W., additional, Ganslandt, Thomas, additional, García-Barrio, Noelia, additional, Garmire, Lana X., additional, Gehlenborg, Nils, additional, Getzen, Emily J., additional, Geva, Alon, additional, González, Tomás González, additional, Gradinger, Tobias, additional, Gramfort, Alexandre, additional, Griffier, Romain, additional, Griffon, Nicolas, additional, Grisel, Olivier, additional, Guzzi, Pietro H., additional, Han, Larry, additional, Haverkamp, Christian, additional, Hazard, Derek Y., additional, He, Bing, additional, Henderson, Darren W., additional, Hilka, Martin, additional, Honerlaw, Jacqueline P., additional, Huling, Kenneth M., additional, Issitt, Richard W., additional, Jannot, Anne Sophie, additional, Jouhet, Vianney, additional, Kavuluru, Ramakanth, additional, Keller, Mark S., additional, Kennedy, Chris J., additional, Kernan, Kate F., additional, Key, Daniel A., additional, Kirchoff, Katie, additional, Krantz, Ian D., additional, Kraska, Detlef, additional, Krishnamurthy, Ashok K., additional, L'Yi, Sehi, additional, Le, Trang T., additional, Leblanc, Judith, additional, Lemaitre, Guillaume, additional, Lenert, Leslie, additional, Leprovost, Damien, additional, Liu, Molei, additional, Will Loh, Ne Hooi, additional, Long, Qi, additional, Lozano-Zahonero, Sara, additional, Lynch, Kristine E., additional, Mahmood, Sadiqa, additional, Makwana, Simran, additional, Mandl, Kenneth D., additional, Mao, Chengsheng, additional, Maram, Anupama, additional, Maripuri, Monika, additional, Martel, Patricia, additional, Martins, Marcelo R., additional, Marwaha, Jayson S., additional, Masino, Aaron J., additional, Mazzitelli, Maria, additional, Mazzotti, Diego R., additional, Mensch, Arthur, additional, Milano, Marianna, additional, Minicucci, Marcos F., additional, Ahooyi, Taha Mohseni, additional, Moore, Jason H., additional, Moraleda, Cinta, additional, Morris, Jeffrey S., additional, Moshal, Karyn L., additional, Mousavi, Sajad, additional, Murad, Douglas A., additional, Murphy, Shawn N., additional, Naughton, Thomas P., additional, Breda Neto, Carlos Tadeu, additional, Newburger, Jane, additional, Njoroge, Wanjiku F.M., additional, Norman, James B., additional, Obeid, Jihad, additional, Okoshi, Marina P., additional, Olson, Karen L., additional, Orlova, Nina, additional, Ostasiewski, Brian D., additional, Palmer, Nathan P., additional, Paris, Nicolas, additional, Pedrera-Jiménez, Miguel, additional, Pfaff, Ashley C., additional, Pfaff, Emily R., additional, Pillion, Danielle, additional, Pizzimenti, Sara, additional, Priya, Tanu, additional, Prokosch, Hans U., additional, Prudente, Robson A., additional, Prunotto, Andrea, additional, Quirós-González, Víctor, additional, Ramoni, Rachel B., additional, Raskin, Maryna, additional, Rieg, Siegbert, additional, Roig-Domínguez, Gustavo, additional, Rojo, Pablo, additional, Rubio-Mayo, Paula, additional, Sacchi, Paolo, additional, Sáez, Carlos, additional, Salamanca, Elisa, additional, Sanchez-Pinto, L. Nelson, additional, Sandrin, Arnaud, additional, Santhanam, Nandhini, additional, Santos, Janaina C.C., additional, Sanz Vidorreta, Fernando J., additional, Savino, Maria, additional, Schubert, Petra, additional, Schuettler, Juergen, additional, Scudeller, Luigia, additional, Sebire, Neil J., additional, Serrano-Balazote, Pablo, additional, Serre, Patricia, additional, Serret-Larmande, Arnaud, additional, Shah, Mohsin, additional, Hossein Abad, Zahra Shakeri, additional, Silvio, Domenick, additional, Sliz, Piotr, additional, Son, Jiyeon, additional, Sonday, Charles, additional, Sperotto, Francesca, additional, Spiridou, Anastasia, additional, Strasser, Zachary H., additional, Tan, Byorn W.L., additional, Tanni, Suzana E., additional, Taylor, Deanne M., additional, Terriza-Torres, Ana I., additional, Toh, Emma M.S., additional, Torti, Carlo, additional, Trecarichi, Enrico M., additional, Vallejos, Andrew K., additional, Varoquaux, Gael, additional, Vella, Margaret E., additional, Vie, Jill-Jênn, additional, Vitacca, Michele, additional, Wagholikar, Kavishwar B., additional, Waitman, Lemuel R., additional, Wang, Xuan, additional, Wassermann, Demian, additional, Wolkewitz, Martin, additional, Wong, Scott, additional, Xiong, Xin, additional, Ye, Ye, additional, Yehya, Nadir, additional, Zachariasse, Joany M., additional, Zahner, Janet J., additional, Zambelli, Alberto, additional, Zuccaro, Valentina, additional, and Zucco, Chiara, additional

Published
2023
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44. International comparisons of laboratory values from the 4CE collaborative to predict COVID-19 mortality

Author

Weber, Griffin, Hong, Chuan, Xia, Zongqi, Palmer, Nathan, Avillach, Paul, L’yi, Sehi, Keller, Mark, Murphy, Shawn, Gutiérrez-Sacristán, Alba, Bonzel, Clara-Lea, Serret-Larmande, Arnaud, Neuraz, Antoine, Omenn, Gilbert, Visweswaran, Shyam, Klann, Jeffrey, South, Andrew, Loh, Ne Hooi Will, Cannataro, Mario, Beaulieu-Jones, Brett, Bellazzi, Riccardo, Agapito, Giuseppe, Alessiani, Mario, Aronow, Bruce, Bell, Douglas, Benoit, Vincent, Bourgeois, Florence, Chiovato, Luca, Cho, Kelly, Dagliati, Arianna, Duvall, Scott, Barrio, Noelia García, Hanauer, David, Ho, Yuk-Lam, Holmes, John, Issitt, Richard, Liu, Molei, Luo, Yuan, Lynch, Kristine, Maidlow, Sarah, Malovini, Alberto, Mandl, Kenneth, Mao, Chengsheng, Matheny, Michael, Moore, Jason, Morris, Jeffrey, Morris, Michele, Mowery, Danielle, Ngiam, Kee Yuan, Patel, Lav, Pedrera Jiménez, Miguel, Ramoni, Rachel, Schriver, Emily, Schubert, Petra, Balazote, Pablo Serrano, Spiridou, Anastasia, Tan, Amelia, Tan, Byorn, Tibollo, Valentina, Torti, Carlo, Trecarichi, Enrico, Wang, Xuan, Aaron, James, Albayrak, Adem, Albi, Giuseppe, Balshi, James, Alloni, Anna, Amendola, Danilo, Angoulvant, François, Anthony, Li, Ashraf, Fatima, Atz, Andrew, Azevedo, Paula, Bellasi, Antonio, Beraghi, Michele, Bernal-Sobrino, José Luis, Bernaux, Mélodie, Bey, Romain, Bhatnagar, Surbhi, Blanco-Martínez, Alvar, Boeker, Martin, Booth, John, Bosari, Silvano, Bradford, Robert, Brat, Gabriel, Bréant, Stéphane, Brown, Nicholas, Bruno, Raffaele, Bryant, William, Bucalo, Mauro, Bucholz, Emily, Burgun, Anita, Cai, Tianxi, Carmona, Aldo, Caucheteux, Charlotte, Champ, Julien, Chen, Krista, Chen, Jin, Chiudinelli, Lorenzo, Cimino, James, Colicchio, Tiago, Cormont, Sylvie, Cossin, Sébastien, Craig, Jean, Cruz-Bermúdez, Juan Luis, Cruz-Rojo, Jaime, Daniar, Mohamad, Daniel, Christel, Das, Priyam, Devkota, Batsal, Garmire, Lana, Dionne, Audrey, Duan, Rui, Dubiel, Julien, Esteve, Loic, Estiri, Hossein, Fan, Shirley, Follett, Robert, Ganslandt, Thomas, García-Barrio, Noelia, Gehlenborg, Nils, Getzen, Emily, Geva, Alon, Gradinger, Tobias, Gramfort, Alexandre, Griffier, Romain, Griffon, Nicolas, Grisel, Olivier, Han, Larry, Haverkamp, Christian, Key, Daniel, Hazard, Derek, He, Bing, Henderson, Darren, Hilka, Martin, Huling, Kenneth, Hutch, Meghan, Jannot, Anne Sophie, Jouhet, Vianney, Kavuluru, Ramakanth, Kennedy, Chris, Kernan, Kate, Kirchoff, Katie, Kohane, Isaac, Krantz, Ian, Kraska, Detlef, Krishnamurthy, Ashok, Le, Trang, Leblanc, Judith, Lemaitre, Guillaume, Lenert, Leslie, Leprovost, Damien, Long, Qi, Lozano-Zahonero, Sara, Mahmood, Sadiqa, Makoudjou, Adeline, Maram, Anupama, Martel, Patricia, Martins, Marcelo, Marwaha, Jayson, Masino, Aaron, Mazzitelli, Maria, Mensch, Arthur, Milano, Marianna, Minicucci, Marcos, Moal, Bertrand, Ahooyi, Taha Mohseni, Moraleda, Cinta, Moshal, Karyn, Mousavi, Sajad, Murad, Douglas, Naughton, Thomas, Neto, Carlos Tadeu Breda, Newburger, Jane, Njoroge, Wanjiku, Norman, James, Obeid, Jihad, Okoshi, Marina, Olson, Karen, Orlova, Nina, Ostasiewski, Brian, Paris, Nicolas, Pedrera-Jiménez, Miguel, Pfaff, Ashley, Pfaff, Emily, Pillion, Danielle, Pizzimenti, Sara, Prokosch, Hans, Prudente, Robson, Prunotto, Andrea, Quirós-González, Víctor, Raskin, Maryna, Rieg, Siegbert, Roig-Domínguez, Gustavo, Rojo, Pablo, Rubio-Mayo, Paula, Sacchi, Paolo, Sáez, Carlos, Salamanca, Elisa, Samayamuthu, Malarkodi Jebathilagam, Sanchez-Pinto, L. Nelson, Sandrin, Arnaud, Santhanam, Nandhini, Santos, Janaina, Sanz Vidorreta, Fernando, Savino, Maria, Schuettler, Juergen, Scudeller, Luigia, Sebire, Neil, Serrano-Balazote, Pablo, Serre, Patricia, Shah, Mohsin, Abad, Zahra Shakeri Hossein, Silvio, Domenick, Sliz, Piotr, Son, Jiyeon, Sonday, Charles, Sperotto, Francesca, Strasser, Zachary, Tan, Bryce, Tanni, Suzana, Taylor, Deanne, Terriza-Torres, Ana, Tippmann, Patric, Toh, Emma, Tseng, Yi-Ju, Vallejos, Andrew, Varoquaux, Gael, Vella, Margaret, Verdy, Guillaume, Vie, Jill-Jênn, Vitacca, Michele, Wagholikar, Kavishwar, Waitman, Lemuel, Wassermann, Demian, Wolkewitz, Martin, Wong, Scott, Xiong, Xin, Ye, Ye, Yehya, Nadir, Yuan, William, Zambelli, Alberto, Zhang, Harrison, Zöller, Daniela, Zuccaro, Valentina, Zucco, Chiara, Harvard Medical School [Boston] (HMS), University of Pittsburgh (PITT), Pennsylvania Commonwealth System of Higher Education (PCSHE), Massachusetts General Hospital [Boston], Centre de Recherche des Cordeliers (CRC (UMR_S_1138 / U1138)), École Pratique des Hautes Études (EPHE), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU)-Université Paris Cité (UPCité), Service d'informatique médicale et biostatistiques [CHU Necker], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-CHU Necker - Enfants Malades [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Université Paris Cité (UPCité), Health data- and model- driven Knowledge Acquisition (HeKA), Inria de Paris, Institut National de Recherche en Informatique et en Automatique (Inria)-Institut National de Recherche en Informatique et en Automatique (Inria)-Centre de Recherche des Cordeliers (CRC (UMR_S_1138 / U1138)), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU)-Université Paris Cité (UPCité)-École Pratique des Hautes Études (EPHE), University of Michigan [Ann Arbor], University of Michigan System, Wake Forest School of Medicine [Winston-Salem], Wake Forest Baptist Medical Center, National University Health System [Singapore] (NUHS), Università degli Studi 'Magna Graecia' di Catanzaro = University of Catanzaro (UMG), Università degli Studi di Pavia = University of Pavia (UNIPV), Istituti Clinici Scientifici Maugeri [Pavia] (IRCCS Pavia - ICS Maugeri), ASST Pavia, University of Cincinnati (UC), University of California [Los Angeles] (UCLA), University of California (UC), VA Boston Healthcare System, Hospital Universitario 12 de Octubre [Madrid], University of Pennsylvania, Great Ormond Street Hospital for Children [London] (GOSH), Harvard School of Public Health, Northwestern University [Chicago, Ill. USA], VA Salt Lake City Health Care System, Boston Children's Hospital, University of Kansas [Kansas City], and National University Hospital [Singapore] (NUH)

Subjects
Health Information Management, Medicine (miscellaneous), Health Informatics, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, Computer Science Applications
Abstract

Given the growing number of prediction algorithms developed to predict COVID-19 mortality, we evaluated the transportability of a mortality prediction algorithm using a multi-national network of healthcare systems. We predicted COVID-19 mortality using baseline commonly measured laboratory values and standard demographic and clinical covariates across healthcare systems, countries, and continents. Specifically, we trained a Cox regression model with nine measured laboratory test values, standard demographics at admission, and comorbidity burden pre-admission. These models were compared at site, country, and continent level. Of the 39,969 hospitalized patients with COVID-19 (68.6% male), 5717 (14.3%) died. In the Cox model, age, albumin, AST, creatine, CRP, and white blood cell count are most predictive of mortality. The baseline covariates are more predictive of mortality during the early days of COVID-19 hospitalization. Models trained at healthcare systems with larger cohort size largely retain good transportability performance when porting to different sites. The combination of routine laboratory test values at admission along with basic demographic features can predict mortality in patients hospitalized with COVID-19. Importantly, this potentially deployable model differs from prior work by demonstrating not only consistent performance but also reliable transportability across healthcare systems in the US and Europe, highlighting the generalizability of this model and the overall approach.

Published
2022
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45. Congenital cytomegalovirus infection in newborns born to HIV-infected mothers

Author

Prieto, Luis M., primary, Blázquez Gamero, Daniel, additional, Rubio Mancha, Irene, additional, Torres Pastor, Belén, additional, Epalza Ibarrondo, Cristina, additional, Rojo Conejo, Pablo, additional, Ramos Amador, José Tomás, additional, Fer-nández Cooke, Elisa, additional, Manzanares, Ángela, additional, Mazariegos, Diana, additional, Moraleda, Cinta, additional, Muñoz, Alberto, additional, Prieto, Luis M., additional, Torres Fernández, David, additional, and Villaverde, Serena, additional

Published
2022
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48. Comparison of pneumonia features in children caused by SARS‐CoV‐2 and other viral respiratory pathogens

Author

del Valle, Rut, primary, Ballesteros, Álvaro, additional, Calvo, Cristina, additional, Sainz, Talía, additional, Mendez, Ana, additional, Grasa, Carlos, additional, Molina, Paula R., additional, Mellado, María J., additional, Sanz‐Santaeufemia, Francisco J., additional, Herrero, Blanca, additional, Calleja, Lourdes, additional, Soriano‐Arandes, Antoni, additional, Melendo, Susana, additional, Rincón‐López, Elena, additional, Hernánz, Alicia, additional, Epalza, Cristina, additional, García‐Baeza, Carmen, additional, Rupérez‐García, E., additional, Berzosa, Arantxa, additional, Ocaña, Angustias, additional, Villarroya‐Villalba, Alvaro, additional, Barrios, Ana, additional, Otheo, Enrique, additional, Galán, Juan C., additional, Rodríguez, Mario José, additional, Mesa, Juan M., additional, Domínguez‐Rodríguez, Sara, additional, Moraleda, Cinta, additional, and Tagarro, Alfredo, additional

Published
2022
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49. Treatments for multi-system inflammatory syndrome in children - discharge, fever, and second-line therapies

Author

Tagarro, Alfredo, Domínguez-Rodríguez, Sara, Mesa, Juan Miguel, Epalza, Cristina, Grasa, Carlos, Iglesias-Bouzas, María Isabel, Fernández-Cooke, Elisa, Calvo, Cristina, Villaverde, Serena, Torres-Fernández, David, Méndez-Echevarria, Ana, Leoz, Inés, Fernández-Pascual, María, Saavedra-Lozano, Jesús, Soto, Beatriz, Aguilera-Alonso, David, Rivière, Jacques G, Fumadó, Victoria, Martínez-Campos, Leticia, Vivanco, Ana, Pilar-Orive, Francisco Javier, Alcalá, Pedro, Ruiz, Beatriz, López-Machín, Ana, Oltra, Manuel, Moraleda, Cinta, and EPICO Working Group

Subjects
Fever, SARS-CoV-2, Pediatrics, Perinatology and Child Health, COVID-19, Humans, Immunoglobulins, Intravenous, MIS-C, Steroids, Child, Children, Patient Discharge, Retrospective Studies
Abstract

Scarce evidence exists about the best treatment for multi-system inflammatory syndrome (MIS-C). We analyzed the effects of steroids, intravenous immunoglobulin (IVIG), and their combination on the probability of discharge over time, the probability of switching to second-line treatment over time, and the persistence of fever 2 days after treatment. We did a retrospective study to investigate the effect of different treatments on children with MIS-C from 1 March 2020 to 1 June 2021. We estimated the time-to-event probability using a Cox model weighted by propensity score to balance the baseline characteristics. Thirty of 132 (22.7%) patients were initially treated with steroids alone, 29/132 (21.9%) with IVIG alone, and 73/132 (55%) with IVIG plus steroids. The probability of early discharge was higher with IVIG than with IVIG plus steroids (hazard ratio [HR] 1.65, 95% CI 1.11-2.45, p = 0.013), but with a higher probability of needing second-line therapy compared to IVIG plus steroids (HR 3.05, 95% CI 1.12-8.25, p = 0.028). Patients on IVIG had a higher likelihood of persistent fever than patients on steroids (odds ratio [OR] 4.23, 95% CI 1.43-13.5, p = 0.011) or on IVIG plus steroids (OR 4.4, 95% CI 2.05-9.82, p 0.001). No differences were found for this endpoint between steroids or steroids plus IVIG. Conclusions: The benefits of each approach may vary depending on the outcome assessed. IVIG seemed to increase the probability of earlier discharge over time but also of needing second-line treatment over time. Steroids seemed to reduce persistent fever, and combination therapy reduced the need for escalating treatment. What is Known: • Steroids plus intravenous immunoglobulin, compared with intravenous immunoglobulin alone for multi-system inflammatory syndrome (MIS-C) might reduce the need for hemodynamic support and the duration of fever, but the certainty of the evidence is low. What is New: • Intravenous immunoglobulin, steroids, and their combination for MIS-C may have different outcomes. • In this study, intravenous immunoglobulin increased the probability of discharge over time, steroids reduced persistent fever, while combination therapy reduced the need for second-line treatments.

Published
2022

50. Viruses and Mycoplasma pneumoniae are the main etiological agents of community-acquired pneumonia in hospitalized pediatric patients in Spain

Author

Instituto de Investigación Hospital 12 de Octubre, Instituto de Salud Carlos III, European Commission, Instituto Ramón y Cajal de Investigación Sanitaria (España), Universidad Europea de Madrid, Otheo, Enrique [10000-0001-9891-0456], Otheo, Enrique, Rodríguez Peña, Mario, Moraleda, Cinta, Domínguez-Rodríguez, Sara, Martín, María D., Herreros, María L., Vázquez, Carmen, Folgueira, María D., Pérez-Rivilla, Alfredo, Jensen, Julia, López, Agustín, Berzosa, Arantxa, Sanz de Santaeufemia, Francisco J., Jiménez, Ana B., Sainz, Talía, Llorente, Marta, Santos, Mar, Garrote, Elisa, Muñoz, Cristina, Sánchez, Paula, Illán, Marta, Coca, Ana, Barrios, Ana, Pacheco, Mónica, Arquero, Carmen, Gutiérrez, Lourdes, Epalza, Cristina, Rojo, Pablo, Serna-Pascual, Miquel, Mota, Inmaculada, Moreno, Santiago, Galán, Juan C., Tagarro, Alfredo, Instituto de Investigación Hospital 12 de Octubre, Instituto de Salud Carlos III, European Commission, Instituto Ramón y Cajal de Investigación Sanitaria (España), Universidad Europea de Madrid, Otheo, Enrique [10000-0001-9891-0456], Otheo, Enrique, Rodríguez Peña, Mario, Moraleda, Cinta, Domínguez-Rodríguez, Sara, Martín, María D., Herreros, María L., Vázquez, Carmen, Folgueira, María D., Pérez-Rivilla, Alfredo, Jensen, Julia, López, Agustín, Berzosa, Arantxa, Sanz de Santaeufemia, Francisco J., Jiménez, Ana B., Sainz, Talía, Llorente, Marta, Santos, Mar, Garrote, Elisa, Muñoz, Cristina, Sánchez, Paula, Illán, Marta, Coca, Ana, Barrios, Ana, Pacheco, Mónica, Arquero, Carmen, Gutiérrez, Lourdes, Epalza, Cristina, Rojo, Pablo, Serna-Pascual, Miquel, Mota, Inmaculada, Moreno, Santiago, Galán, Juan C., and Tagarro, Alfredo

Abstract

[Objectives]: To describe the etiology of community-acquired pneumonia (CAP) in hospitalized children in Spain and analyze the predictors of the etiology., [Hypothesis]: The different etiological groups of pediatric CAP are associated with different clinical, radiographic, and analytical data., [Design]: Observational, multicenter, and prospective study., [Patient selection]: This study included children aged 1 month to 17 years with CAP, who were hospitalized between April 2012 and May 2019., [Methods]: An extensive microbiological workup was performed. The clinical, radiographic, and analytical parameters were analyzed for three etiological groups., [Results]: Among the 495 children included, at least one causative pathogen was identified in 262 (52.9%): pathogenic viruses in 155/262 (59.2%); atypical bacteria (AB), mainly Mycoplasma pneumonia, in 84/262 (32.1%); and typical bacteria (TyB) in 40/262 (15.3%). Consolidation was observed in 89/138 (64.5%) patients with viral CAP, 74/84 (88.1%) with CAP caused by AB, and 40/40 (100%) with CAP caused by TyB. Para-pneumonic pleural effusion (PPE) was observed in 112/495 (22.6%) patients, of which 61/112 (54.5%) presented a likely causative pathogen: viruses in 12/61 (19.7%); AB in 23/61 (37.7%); and TyB in 26/61 (42.6%). Viral etiology was significantly frequent in young patients and in those with low oxygen saturation, wheezing, no consolidation, and high lymphocyte counts. CAP patients with AB as the etiological agent had a significantly longer and less serious course as compared to those with other causative pathogens., [Conclusions]: Viruses and M. pneumoniae are the main causes of pediatric CAP in Spain. Wheezing, young age, and no consolidation on radiographs are indicative of viral etiology. Viruses and AB can also cause PPE. Since only a few cases can be directly attributed to TyB, the indications for antibiotics must be carefully considered in each patient.

Published
2022

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