353 results on '"Morandi, Andrea"'
Search Results
2. FADS1/2 control lipid metabolism and ferroptosis susceptibility in triple-negative breast cancer
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Lorito, Nicla, Subbiani, Angela, Smiriglia, Alfredo, Bacci, Marina, Bonechi, Francesca, Tronci, Laura, Romano, Elisabetta, Corrado, Alessia, Longo, Dario Livio, Iozzo, Marta, Ippolito, Luigi, Comito, Giuseppina, Giannoni, Elisa, Meattini, Icro, Avgustinova, Alexandra, Chiarugi, Paola, Bachi, Angela, and Morandi, Andrea
- Published
- 2024
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3. Large-scale photonic computing with nonlinear disordered media
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Wang, Hao, Hu, Jianqi, Morandi, Andrea, Nardi, Alfonso, Xia, Fei, Li, Xuanchen, Savo, Romolo, Liu, Qiang, Grange, Rachel, and Gigan, Sylvain
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Physics - Optics ,Computer Science - Emerging Technologies - Abstract
Neural networks find widespread use in scientific and technological applications, yet their implementations in conventional computers have encountered bottlenecks due to ever-expanding computational needs. Photonic neuromorphic hardware, which manipulates information and represents data continuously in the optical domain, is one of the promising platforms with potential advantages of massive parallelism, ultralow latency, and reduced energy consumption. While linear photonic neural networks are within reach, photonic computing with large-scale optical nonlinear nodes remains largely unexplored. Here, we demonstrate a large-scale, high-performance nonlinear photonic neural system based on a disordered polycrystalline slab composed of lithium niobate nanocrystals. Mediated by random quasi-phase-matching and multiple scattering, linear and nonlinear optical speckle features are generated as the interplay between the simultaneous linear random scattering and the second-harmonic generation, defining a complex neural network in which the second-order nonlinearity acts as internal nonlinear activation functions. Benchmarked against linear random projection, such nonlinear mapping embedded with rich physical computational operations shows improved performance across a large collection of machine learning tasks in image classification, regression, and graph classification with varying complexity. Demonstrating up to 27,648 input and 3,500 nonlinear output nodes, the combination of optical nonlinearity and random scattering serves as a scalable computing engine for diverse applications.
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- 2023
4. Large-scale photonic computing with nonlinear disordered media
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Wang, Hao, Hu, Jianqi, Morandi, Andrea, Nardi, Alfonso, Xia, Fei, Li, Xuanchen, Savo, Romolo, Liu, Qiang, Grange, Rachel, and Gigan, Sylvain
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- 2024
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5. Graph model for multiple scattering in lithium niobate on insulator integrated photonic networks
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Wang, Xiyue Sissi, Savo, Romolo, Maeder, Andreas, Kaufmann, Fabian, Kellner, Jost, Morandi, Andrea, Rotter, Stefan, Sapienza, Riccardo, and Grange, Rachel
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Physics - Optics ,Physics - Applied Physics - Abstract
We present a graph-based model for multiple scattering of light in integrated lithium niobate on insulator (LNOI) networks, which describes an open network of single-mode integrated waveguides with tunable scattering at the network nodes. We first validate the model at small scale with experimental LNOI resonator devices and show consistent agreement between simulated and measured spectral data. Then, the model is used to demonstrate a novel platform for on-chip multiple scattering in large-scale optical networks up to few hundred nodes, with tunable scattering behaviour and tailored disorder. Combining our simple graph-based model with material properties of LNOI, this platform creates new opportunities to control randomness in large optical networks.
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- 2023
6. Broadband photon pair generation from a single lithium niobate microcube
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Duong, Ngoc My Hanh, Saerens, Gregoire, Timpu, Flavia, Buscaglia, Maria Teresa, Buscaglia, Vincenzo, Morandi, Andrea, Muller, Jolanda S., Maeder, Andreas, Kaufmann, Fabian, Sonltsev, Alexander, and Grange, Rachel
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Quantum Physics ,Condensed Matter - Materials Science - Abstract
Nonclassical light sources are highly sought after as they are an integral part of quantum communication and quantum computation devices. Typical sources rely on bulk crystals that are not compact and have limited bandwidth due to phase-matching conditions. In this work, we demonstrate the generation of photon pairs from a free-standing lithium niobate microcube at the telecommunication wavelength through the spontaneous parametric down-conversion process. The maximum photon pair generation rate obtained from a single microcube with the size of ~4 microns is ~80 Hz, resulting in an efficiency of ~1.2 GHz/Wm per unit volume, which is an order of magnitude higher than the efficiency of photon-pair generation in bulky nonlinear crystals. The microcubes are synthesized through a solvothermal method, offering the possibility for scalable devices via bottom-up assembly. Our work constitutes an important step forward in the realization of compact nonclassical light sources with broadband tunability for various applications in quantum communication, quantum computing, and quantum metrology., Comment: 19 pages, 4 figures
- Published
- 2021
7. Essential requirements for reporting radiation therapy in breast cancer clinical trials: An international multi-disciplinary consensus endorsed by the European Society for Radiotherapy and Oncology (ESTRO)
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Kaidar-Person, Orit, Meattini, Icro, Boersma, Liesbeth J., Becherini, Carlotta, Cortes, Javier, Curigliano, Giuseppe, de Azambuja, Evandro, Harbeck, Nadia, Rugo, Hope S., Del Mastro, Lucia, Gennari, Alessandra, Isacke, Clare M., Vestmø Maraldo, Maja, Marangoni, Elisabetta, Nader Marta, Gustavo, Mjaaland, Ingvil, Salvestrini, Viola, Spanic, Tanja, Visani, Luca, Morandi, Andrea, Lambertini, Matteo, Livi, Lorenzo, Coles, Charlotte E., Poortmans, Philip, and Offersen, Birgitte V.
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- 2024
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8. Oxidative phosphorylation is a metabolic vulnerability of endocrine therapy and palbociclib resistant metastatic breast cancers
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El-Botty, Rania, Morriset, Ludivine, Montaudon, Elodie, Tariq, Zakia, Schnitzler, Anne, Bacci, Marina, Lorito, Nicla, Sourd, Laura, Huguet, Léa, Dahmani, Ahmed, Painsec, Pierre, Derrien, Heloise, Vacher, Sophie, Masliah-Planchon, Julien, Raynal, Virginie, Baulande, Sylvain, Larcher, Thibaut, Vincent-Salomon, Anne, Dutertre, Guillaume, Cottu, Paul, Gentric, Géraldine, Mechta-Grigoriou, Fatima, Hutton, Scott, Driouch, Keltouma, Bièche, Ivan, Morandi, Andrea, and Marangoni, Elisabetta
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- 2023
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9. International multidisciplinary consensus on the integration of radiotherapy with new systemic treatments for breast cancer: European Society for Radiotherapy and Oncology (ESTRO)-endorsed recommendations
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Alkner, Sara, Bhattacharya, Indrani S., Boersma, Liesbeth, Callari, Maurizio, Clarke, Robert B., Del Mastro, Lucia, Ekholm, Maria, Gennari, Alessandra, Kirby, Anna M., Kroeze, Stephanie, Malumbres, Marcos, Vestmø Maraldo, Maja, Marta, Gustavo Nader, Mjaaland, Ingvil, Morgan, Gilberto, Pistilli, Barbara, Paluch-Shimon, Shani, Rivera, Sofia, Rottenberg, Sven, Saura, Cristina, Skyttä, Tanja, Spanic, Tanja, Meattini, Icro, Becherini, Carlotta, Caini, Saverio, Coles, Charlotte E, Cortes, Javier, Curigliano, Giuseppe, de Azambuja, Evandro, Isacke, Clare M, Harbeck, Nadia, Kaidar-Person, Orit, Marangoni, Elisabetta, Offersen, Birgitte V, Rugo, Hope S, Salvestrini, Viola, Visani, Luca, Morandi, Andrea, Lambertini, Matteo, Poortmans, Philip, and Livi, Lorenzo
- Published
- 2024
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10. Modeling of Random Quasi-Phase-Matching in Birefringent Disordered Media
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Müller, Jolanda S., Morandi, Andrea, Grange, Rachel, and Savo, Romolo
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Physics - Optics ,Condensed Matter - Disordered Systems and Neural Networks ,Condensed Matter - Mesoscale and Nanoscale Physics - Abstract
We provide a vectorial model to simulate second-harmonic generation (SHG) in birefringent, transparent media with an arbitrary configuration of non-linear ($\chi^{(2)}$) crystalline grains. We apply this model on disordered assemblies of LiNbO$_3$ and BaTiO$_3$ grains to identify the influence of the birefringence on the random quasi-phase-matching process. We show that in monodispersed assemblies, the birefringence relaxes the grain-size dependence of the SHG efficiency. In polydispersed assemblies with sufficiently large grains, we find that the birefringence introduces an SHG efficiency enhancement of up to 54% compared to isotropic reference crystals, which is grain size independent. This enhancement increases linearly with the grain size, if the birefringent grains can be phase matched. These two different scaling behaviours are used in Kurtz and Perry's powder-technique to identify the phase-matchability of a material. We show on the example of LiNbO$_3$ and ADP that this technique cannot be applied when the grains get smaller than the coherence length, because the SHG scaling with the grain size becomes material specific., Comment: Main: 7 pages, 4 Figures. Supplementaries: 11 pages, 8 figures
- Published
- 2020
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11. Broadband Mie-driven random quasi-phase-matching
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Savo, Romolo, Morandi, Andrea, Müller, Jolanda S., Kaufmann, Fabian, Timpu, Flavia, Escalé, Marc Reig, Zanini, Michele, Isa, Lucio, and Grange, Rachel
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Physics - Optics ,Condensed Matter - Disordered Systems and Neural Networks ,Condensed Matter - Mesoscale and Nanoscale Physics - Abstract
High-quality crystals without inversion symmetry are the conventional platform to achieve optical frequency conversion via three wave-mixing. In bulk crystals, efficient wave-mixing relies on phase-matching configurations, while at the micro- and nano-scale it requires resonant mechanisms that enhance the nonlinear light-matter interaction. These strategies commonly result in wavelength-specific performances and narrowband applications. Disordered photonic materials, made up of a random assembly of optical nonlinear crystals, enable a broadband tunability in the random quasi-phase-matching (RQPM) regime and do not require high-quality materials. Here, we combine resonances and disorder by implementing RQPM in Mie-resonant spheres of a few microns realized by the bottom-up assembly of barium titanate nano-crystals. The measured second harmonic generation (SHG) reveals a combination of broadband and resonant wave mixing, in which Mie resonances drive and enhance the SHG, while the disorder keeps the phase-matching conditions relaxed. This new phase-matching regime can be described by a random walk in the SHG complex plane whose step lengths depend on the local field enhancement within the micro-sphere. Our nano-crystals assemblies provide new opportunities for tailored phase-matching at the micro-scale, beyond the coherence length of the bulk crystal. They can be adapted to achieve frequency conversion from the near-ultraviolet to the infrared ranges, they are low-cost and scalable to large surface areas., Comment: Main: 9 pages, 5 Figures. Supplementaries: 24 pages, 11 figures, 1 table
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- 2020
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12. Sex difference in liver diseases: How preclinical models help to dissect the sex-related mechanisms sustaining NAFLD and hepatocellular carcinoma
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Smiriglia, Alfredo, Lorito, Nicla, Serra, Marina, Perra, Andrea, Morandi, Andrea, and Kowalik, Marta Anna
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- 2023
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13. Safety profile of cyclin-dependent kinase (CDK) 4/6 inhibitors with concurrent radiation therapy: A systematic review and meta-analysis
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Becherini, Carlotta, Visani, Luca, Caini, Saverio, Bhattacharya, Indrani S., Kirby, Anna M., Nader Marta, Gustavo, Morgan, Gilberto, Salvestrini, Viola, Coles, Charlotte E., Cortes, Javier, Curigliano, Giuseppe, de Azambuja, Evandro, Harbeck, Nadia, Isacke, Clare M., Kaidar-Person, Orit, Marangoni, Elisabetta, Offersen, Birgitte, Rugo, Hope S., Morandi, Andrea, Lambertini, Matteo, Poortmans, Philip, Livi, Lorenzo, and Meattini, Icro
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- 2023
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14. Safety profile of trastuzumab-emtansine (T-DM1) with concurrent radiation therapy: A systematic review and meta-analysis
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Salvestrini, Viola, Kim, Kyubo, Caini, Saverio, Alkner, Sara, Ekholm, Maria, Skyttä, Tanja, Becherini, Carlotta, Coles, Charlotte E., Kaidar-Person, Orit, Offersen, Birgitte, de Azambuja, Evandro, Visani, Luca, Cortes, Javier, Harbeck, Nadia, Rugo, Hope S., Isacke, Clare M., Marangoni, Elisabetta, Morandi, Andrea, Lambertini, Matteo, Poortmans, Philip, Livi, Lorenzo, and Meattini, Icro
- Published
- 2023
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15. Local tuning of WS2 photoluminescence using polymeric micro-actuators in a monolithic van der Waals heterostructure
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Colangelo, Francesco, Morandi, Andrea, Forti, Stiven, Fabbri, Filippo, Coletti, Camilla, Di Girolamo, Flavia Viola, Di Lieto, Alberto, Tonelli, Mauro, Tredicucci, Alessandro, Pitanti, Alessandro, and Roddaro, Stefano
- Subjects
Condensed Matter - Mesoscale and Nanoscale Physics ,Condensed Matter - Materials Science - Abstract
The control of the local strain profile in 2D materials offers an invaluable tool for tailoring the electronic and photonic properties of solid-state devices. In this paper, we demonstrate a local engineering of the exciton photoluminescence (PL) energy of monolayer tungsten disulfide (WS2) by means of strain. We apply a local uniaxial stress to WS2 by exploiting electron-beam patterned and actuated polymeric micrometric artificial muscles (MAMs), which we implement onto monolithic synthetic WS2/graphene heterostructures. We show that MAMs are able to induce an in-plane stress to the top WS2 layer of the van der Waals heterostructure and that the latter can slide on the graphene underneath with negligible friction. As a proof of concept for the local strain-induced PL shift experiments, we exploit a two-MAM configuration in order to apply uniaxial tensile stress on well-defined micrometric regions of WS2. Remarkably, our architecture does not require the adoption of fragile suspended microstructures. We observe a spatial modulation of the excitonic PL energy of the WS2 monolayers under stress, which agrees with the expected strain profile and attains a maximum redshift of about 40 meV at the maximum strain intensity point. After the actuation, a time-dependent PL blueshift is observed in agreement with the viscoelastic properties of the polymeric MAMs. Our approach enables inducing local and arbitrary deformation profiles and circumvents some key limitations and technical challenges of alternative strain engineering methods requiring the 2D material transfer and production of suspended membranes., Comment: This article may be downloaded for personal use only. Any other use requires prior permission of the author and AIP Publishing. This article appeared in APL and may be found at https://aip.scitation.org/doi/10.1063/1.5122262
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- 2019
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16. Estrogen-dependent TRX2 activation reverts oxidative stress and metabolic dysfunction associated to steatotic disease
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Morandi, Andrea, primary, Smiriglia, Alfredo, additional, Lorito, Nicla, additional, Bacci, Marina, additional, Subbiani, Angela, additional, Bonechi, Francesca, additional, Comito, Giuseppina, additional, Kowalik, Marta Anna, additional, and Perra, Andrea, additional
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- 2024
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17. Modified Gravity (MOG) and its test on galaxy clusters
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Nieuwenhuizen, Theodorus M., Morandi, Andrea, and Limousin, Marceau
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Astrophysics - Cosmology and Nongalactic Astrophysics - Abstract
The MOdified Gravity (MOG) theory of J. Moffat assumes a massive vector particle which causes a repulsive contribution to the tensor gravitation. For the galaxy cluster A1689 new data for the X-ray gas and the strong lensing properties are presented. Fits to MOG are possible by adjusting the galaxy density profile. However, this appears to work as an effective dark matter component, posing a serious problem for MOG. New gas and strong lensing data for the cluster A1835 support these conclusions and point at a tendency of the gas-alone to overestimate the lensing effects in MOG theory., Comment: 6 pages latex, 6 figures. MNRAS accepted
- Published
- 2018
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18. The galaxy group NGC2563
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Morandi, Andrea, Sun, Ming, Mulchaey, John, Nagai, Daisuke, and Bonamente, Massimiliano
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Astrophysics - Cosmology and Nongalactic Astrophysics ,Astrophysics - High Energy Astrophysical Phenomena - Abstract
We present a $Chandra$ study of the hot intragroup medium (hIGM) of the galaxy group NCG2563. The $Chandra$ mosaic observations, with a total exposure time of ~430 ks, allow the gas density to be detected beyond $R_{200}$ and the gas temperature out to 0.75 $R_{200}$. This represents the first observational measurement of the physical properties of a poor groups beyond $R_{500}$. By capitalizing on the exquisite spatial resolution of $Chandra$ that is capable to remove unrelated emission from point sources and substructures, we are able to radially constrain the inhomogeneities of gas ("clumpiness"), gas fraction, temperature and entropy distribution. Although there is some uncertainty in the measurements, we find evidences of gas clumping in the virialization region, with clumping factor of about 2 - 3 at $R_{200}$. The gas clumping-corrected gas fraction is significantly lower than the cosmological baryon budget. These results may indicate a larger impact of the gas inhomogeneities with respect to the prediction from hydrodynamic numerical simulations, and we discuss possible explanations for our findings., Comment: MNRAS in press
- Published
- 2017
19. Acetyl-CoA carboxylase 1 controls a lipid droplet–peroxisome axis and is a vulnerability of endocrine-resistant ER + breast cancer
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Bacci, Marina, primary, Lorito, Nicla, additional, Smiriglia, Alfredo, additional, Subbiani, Angela, additional, Bonechi, Francesca, additional, Comito, Giuseppina, additional, Morriset, Ludivine, additional, El Botty, Rania, additional, Benelli, Matteo, additional, López-Velazco, Joanna I., additional, Caffarel, Maria M., additional, Urruticoechea, Ander, additional, Sflomos, George, additional, Malorni, Luca, additional, Corsini, Michela, additional, Ippolito, Luigi, additional, Giannoni, Elisa, additional, Meattini, Icro, additional, Matafora, Vittoria, additional, Havas, Kristina, additional, Bachi, Angela, additional, Chiarugi, Paola, additional, Marangoni, Elisabetta, additional, and Morandi, Andrea, additional
- Published
- 2024
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20. A Strong Merger Shock in Abell 665
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Dasadia, Sarthak, Sun, Ming, Sarazin, Craig, Morandi, Andrea, Markevitch, Maxim, Wik, Daniel, Feretti, Luigina, Giovannini, Gabriele, Govoni, Federica, and Vacca, Valentina
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Astrophysics - High Energy Astrophysical Phenomena - Abstract
Deep (103 ks) \chandra\ observations of Abell 665 have revealed rich structures in this merging galaxy cluster, including a strong shock and two cold fronts. The newly discovered shock has a Mach number of $M$ = 3.0 $\pm$ 0.6, propagating in front of a cold disrupted cloud. This makes Abell~665 the second cluster where a strong merger shock of $M \approx$ 3 has been detected, after the Bullet cluster. The shock velocity from jump conditions is consistent with (2.7 $\pm$ 0.7) $\times$ 10$^3$ km sec$^{-1}$. The new data also reveal a prominent southern cold front, with potentially heated gas ahead of it. Abell 665 also hosts a giant radio halo. There is a hint of diffuse radio emission extending to the shock at the north, which needs to be examined with better radio data. This new strong shock provides a great opportunity to study the re-acceleration model with the X-ray and radio data combined., Comment: Accepted for publication in ApJL
- Published
- 2016
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21. Shocking Features in the Merging Galaxy Cluster RXJ0334.2-0111
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Dasadia, Sarthak, Sun, Ming, Morandi, Andrea, Sarazin, Craig, Clarke, Tracy, Nulsen, Paul, Massaro, Francesco, Roediger, Elke, Harris, Dan, and Forman, Bill
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Astrophysics - High Energy Astrophysical Phenomena ,Astrophysics - Astrophysics of Galaxies - Abstract
We present a 66 ksec $\textit{Chandra}$ X-ray observation of the galaxy cluster RXJ0334.2-0111. This deep observation revealed a unique bow shock system associated with a wide angle tail (WAT) radio galaxy and several intriguing substructures. The temperature across the bow shock jumps by a factor of $\sim$ 1.5 (from 4.1 keV to 6.2 keV), and is consistent with the Mach number $M = 1.6_{-0.3}^{+0.5}$. A second inner surface brightness edge is a cold front that marks the border between infalling subcluster cool core and the ICM of the main cluster. The temperature across the cold front increases from $1.3_{-0.8}^{+0.3}$ keV to $6.2_{-0.6}^{+0.6}$ keV. We find an overpressurized region $\sim$ 250 kpc east of the cold front that is named "the eastern extension (EE)". The EE may be a part of the third subcluster in the ongoing merger. We also find a tail shaped feature that originates near the bow shock and may extend up to a distance of $\sim$ 1 Mpc. This feature is also likely overpressurized. The luminous FR-I radio galaxy, 3C89, appears to be the cD galaxy of the infalling subcluster. We estimated 3C89's jet power from jet bending and the possible interaction between the X-ray gas and the radio lobes. A comparison between the shock stand-off distance and the Mach number for all known shock front/cold front combinations suggests that the core is continuously shrinking in size by stripping., Comment: Accepted for publication in MNRAS
- Published
- 2016
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22. Probing dark energy via galaxy cluster outskirts
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Morandi, Andrea and Sun, Ming
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Astrophysics - Cosmology and Nongalactic Astrophysics ,Astrophysics - Astrophysics of Galaxies ,Astrophysics - High Energy Astrophysical Phenomena - Abstract
We present a Bayesian approach to combine $Planck$ data and the X-ray physical properties of the intracluster medium in the virialization region of a sample of 320 galaxy clusters ($0.056
3$ keV) observed with $Chandra$. We exploited the high-level of similarity of the emission measure in the cluster outskirts as cosmology proxy. The cosmological parameters are thus constrained assuming that the emission measure profiles at different redshift are weakly self-similar, that is their shape is universal, explicitly allowing for temperature and redshift dependence of the gas fraction. This cosmological test, in combination with $Planck$+SNIa data, allows us to put a tight constraint on the dark energy models. For a constant-$w$ model, we have $w=-1.010\pm0.030$ and $\Omega_m=0.311\pm0.014$, while for a time-evolving equation of state of dark energy $w(z)$ we have $\Omega_m=0.308\pm 0.017$, $w_0=-0.993\pm0.046$ and $w_a=-0.123\pm0.400$. Constraints on the cosmology are further improved by adding priors on the gas fraction evolution from hydrodynamic simulations. Current data favour the cosmological constant with $w\equiv-1$, with no evidence for dynamic dark energy. We checked that our method is robust towards different sources of systematics, including background modelling, outlier measurements, selection effects, inhomogeneities of the gas distribution and cosmic filaments. We also provided for the first time constraints on which definition of cluster boundary radius is more tenable, namely based on a fixed overdensity with respect to the critical density of the Universe. This novel cosmological test has the capacity to provide a generational leap forward in our understanding of the equation of state of dark energy., Comment: Accepted for publication in MNRAS - Published
- 2016
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23. Fat and Furious: Lipid Metabolism in Antitumoral Therapy Response and Resistance
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Bacci, Marina, Lorito, Nicla, Smiriglia, Alfredo, and Morandi, Andrea
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- 2021
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24. Accurate modeling of the strong and weak lensing profiles for the galaxy clusters Abell 1689 and 1835
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Nieuwenhuizen, Theodorus M., Limousin, Marceau, and Morandi, Andrea
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- 2021
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25. The galaxy cluster outskirts probed by Chandra
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Morandi, Andrea, Sun, Ming, Forman, William, and Jones, Christine
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Astrophysics - Cosmology and Nongalactic Astrophysics - Abstract
We studied the physical properties of the intracluster medium in the virialization region of a sample of 320 clusters ($0.056
3$ keV) in the Chandra archive. With the emission measure profiles from this large sample, the typical gas density, gas slope and gas fraction can be constrained out to and beyond $R_{200}$. We observe a steepening of the density profiles beyond $R_{500}$ with $\beta \sim 0.68$ at $R_{500}$ and $\beta \sim 1$ at $R_{200}$ and beyond. By tracking the direction of the cosmic filaments approximately with the ICM eccentricity, we report that galaxy clusters deviate from spherical symmetry, with only small differences between relaxed and disturbed systems. We also did not find evolution of the gas density with redshift, confirming its self-similar evolution. The value of the baryon fraction reaches the cosmic value at $R_{200}$: however, systematics due to non-thermal pressure support and clumpiness might enhance the measured gas fraction, leading to an actual deficit of the baryon budget with respect to the primordial value. This study has important implications for understanding the ICM physics in the outskirts., Comment: MNRAS in press: conclusions the same, full data table included - Published
- 2015
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26. Metabolic reprogramming in Nrf2-driven proliferation of normal rat hepatocytes.
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Kowalik, Marta A., Taguchi, Keiko, Serra, Marina, Caddeo, Andrea, Puliga, Elisabetta, Bacci, Marina, Koshiba, Seizo, Inoue, Jin, Hishinuma, Eiji, Morandi, Andrea, Giordano, Silvia, Perra, Andrea, Yamamoto, Masayuki, and Columbano, Amedeo
- Published
- 2024
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27. Essential requirements for reporting radiation therapy in breast cancer clinical trials: an international multi-disciplinary consensus endorsed by the European SocieTy for Radiotherapy and Oncology (ESTRO)
- Author
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Kaidar-Person, Orit, primary, Meattini, Icro, additional, Boersma, Liesbeth J., additional, Becherini, Carlotta, additional, Cortes, Javier, additional, Curigliano, Giuseppe, additional, de Azambuja, Evandro, additional, Harbeck, Nadia, additional, Rugo, Hope S., additional, Del Mastro, Lucia, additional, Gennari, Alessandra, additional, Isacke, Clare M., additional, Vestmø Maraldo, Maja, additional, Marangoni, Elisabetta, additional, Nader Marta, Gustavo, additional, Mjaaland, Ingvil, additional, Salvestrini, Viola, additional, Spanic, Tanja, additional, Visani, Luca, additional, Morandi, Andrea, additional, Lambertini, Matteo, additional, Livi, Lorenzo, additional, Coles, Charlotte E., additional, Poortmans, Philip, additional, and Offersen, Birgitte V., additional
- Published
- 2023
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28. Graph model for multiple scattering in lithium niobate on insulator integrated photonic networks
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Wang, Xiyue Sissi, primary, Savo, Romolo, additional, Maeder, Andreas, additional, Kaufmann, Fabian, additional, Kellner, Jost, additional, Morandi, Andrea, additional, Rotter, Stefan, additional, Sapienza, Riccardo, additional, and Grange, Rachel, additional
- Published
- 2023
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29. Are observations of the galaxy cluster Abell 1689 consistent with a neutrino dark matter scenario?
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Nieuwenhuizen, Theo M. and Morandi, Andrea
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Astrophysics - Cosmology and Nongalactic Astrophysics - Abstract
Recent weak and strong lensing data of the galaxy cluster A1689 are modelled by dark fermions that are quantum degenerate within some core. The gas density, deduced from X-ray observations up to 1 Mpc and obeying a cored power law, is taken as input, while the galaxy mass density is modelled. An additional dark matter tail may arise from cold or warm dark matter, axions or non-degenerate neutrinos. The fit yields that the fermions are degenerate within a 430 kpc radius. The fermion mass is a few eV and the best case involves 3 active plus 3 sterile neutrinos of equal mass, for which we deduce $1.51 \pm 0.04$ eV. The eV mass range will be tested in the KATRIN experiment., Comment: 5 pages latex, 5 figures. Accepted for MNRAS Letters
- Published
- 2013
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30. Measuring the gas clumping in Abell 133
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Morandi, Andrea and Cui, Wei
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Astrophysics - Cosmology and Nongalactic Astrophysics ,Astrophysics - High Energy Astrophysical Phenomena - Abstract
This paper continues a series in which we developed a non-parametric method to measure inhomogeneities in the gas distribution from X-ray observations of galaxy clusters. In this work, we apply our method to Chandra X-ray observations of Abell 133 and present the determination of the gas clumping factor from X-ray cluster data. We find that the gas clumping factor in Abell 133 increases with radius and reaches $\sim 2-3$ at $0.9\,R_{200}$. This is in good agreement with the predictions of hydrodynamical simulations and our previous determination. We then observe a general trend of steepening in the radial profiles of the clumping-corrected gas density beyond $0.3\, R_{200}$, with a logarithmic slope of $\sim 2.6$ at $0.9\,R_{200}$. The observed density profiles appear to be flatter compared to simulations, but in agreement with previous observational findings. In addition, we observe that the measured temperature decreases steadily with radius toward the outskirts of A133, while the entropy increases monotonically with radius, gently flattening in the outer volumes. With respect to theoretical predictions from pure gravitational collapse, the results presented here point to an entropy excess in the central regions, which extends out to large radii. These results suggest that gas inhomogeneities should be treated properly when interpreting X-ray measurements in the envelope of galaxy clusters. We finally discuss how the brightness distribution keeps a record of the large-scale structures formation scenario, providing a snapshot of the 'melting pot' in the virialization region., Comment: MNRAS in press. arXiv admin note: text overlap with arXiv:1305.5256
- Published
- 2013
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31. Non-parametric method for measuring gas inhomogeneities from X-ray observations of galaxy clusters
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Morandi, Andrea, Nagai, Daisuke, and Cui, Wei
- Subjects
Astrophysics - Cosmology and Nongalactic Astrophysics - Abstract
We present a non-parametric method to measure inhomogeneities in the intracluster medium (ICM) from X-ray observations of galaxy clusters. Analysing mock Chandra X-ray observations of simulated clusters, we show that our new method enables the accurate recovery of the 3D gas density and gas clumping factor profiles out to large radii of galaxy clusters. We then apply this method to Chandra X-ray observations of Abell 1835 and present the first determination of the gas clumping factor from the X-ray cluster data. We find that the gas clumping factor in Abell 1835 increases with radius and reaches ~2-3 at r=R_{200}. This is in good agreement with the predictions of hydrodynamical simulations, but it is significantly below the values inferred from recent Suzaku observations. We further show that the radially increasing gas clumping factor causes flattening of the derived entropy profile of the ICM and affects physical interpretation of the cluster gas structure, especially at the large cluster-centric radii. Our new technique should be useful for improving our understanding of the cluster structure and to advance the use of galaxy clusters as cosmological probes, by helping to exploit rich data sets provided by Chandra and XMM-Newton X-ray space telescopes., Comment: MNRAS in press
- Published
- 2013
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32. Reconstructing three-dimensional parameters of galaxy clusters via multifrequency SZ observations
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Morandi, Andrea, Nagai, Daisuke, and Cui, Wei
- Subjects
Astrophysics - Cosmology and Nongalactic Astrophysics - Abstract
The Sunyaev-Zeldovich (SZ) effect is a promising tool to study physical properties of the hot X-ray emitting intracluster medium (ICM) in galaxy clusters. To date, most SZ observations have been interpreted in combination with X-ray follow-up measurements in order to determine the ICM temperature and estimate the cluster mass. Future high-resolution, multifrequency SZ observations promise to enable detailed studies of the ICM structures, by measuring the ICM temperature through the temperature-dependent relativistic corrections. In this work we develop a non-parametric method to derive three-dimensional physical quantities, including temperature, pressure, total mass, and peculiar velocities, of galaxy clusters from SZ observations alone. We test the performance of this method using hydrodynamical simulations of galaxy clusters, in order to assess systematic uncertainties in the reconstructed physical parameters. In particular, we analyze mock Cerro Chajnantor Atacama Telescope (CCAT) SZ observations, taking into account various sources of systematic uncertainties associated with instrumental effects and astrophysical foregrounds. We show that our method enables accurate reconstruction of the three-dimensional ICM profiles, while retaining full information about the gas distribution. We discuss the application of this technique for ongoing and future multifrequency SZ observations., Comment: MNRAS in press
- Published
- 2012
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33. The Three-Dimensional Shapes of Galaxy Clusters
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Limousin, Marceau, Morandi, Andrea, Sereno, Mauro, Meneghetti, Massimo, Ettori, Stefano, Bartelmann, Matthias, and Verdugo, Tomas
- Subjects
Astrophysics - Cosmology and Nongalactic Astrophysics - Abstract
While clusters of galaxies are considered one of the most important cosmological probes, the standard spherical modelling of the dark matter and the intracluster medium is only a rough approximation. Indeed, it is well established both theoretically and observationally that galaxy clusters are much better approximated as triaxial objects. However, investigating the asphericity of galaxy clusters is still in its infancy. We review here this topic which is currently gathering a growing interest from the cluster community. We begin by introducing the triaxial geometry. Then we discuss the topic of deprojection and demonstrate the need for combining different probes of the cluster's potential. We discuss the different works that have been addressing these issues. We present a general parametric framework intended to simultaneously fit complementary data sets (X-ray, Sunyaev Zel'dovich and lensing data). We discuss in details the case of Abell 1689 to show how different models/data sets lead to different haloe parameters. We present the results obtained from fitting a 3D NFW model to X-ray, SZ, and lensing data for 4 strong lensing clusters. We argue that a triaxial model generally allows to lower the inferred value of the concentration parameter compared to a spherical analysis. This may alleviate tensions regarding, e.g. the over-concentration problem. However, we stress that predictions from numerical simulations rely on a spherical analysis of triaxial halos. Given that triaxial analysis will have a growing importance in the observational side, we advocate the need for simulations to be analysed in the very same way, allowing reliable and meaningful comparisons. Besides, methods intended to derive the three dimensional shape of galaxy clusters should be extensively tested on simulated multi-wavelength observations., Comment: (Biased) Review paper. Comments welcome. Accepted for publication in Space Science Reviews. This is a product of the work done by an international team at the International Space Science Institute (ISSI) in Bern on "Astrophysics and Cosmology with Galaxy Clusters: the X-ray and lensing view"
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- 2012
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34. Mass Reconstruction using Particle Based Lensing II: Quantifying substructure with Strong+Weak lensing and X-rays
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Deb, Sanghamitra, Morandi, Andrea, Pedersen, Kristian, Riemer-Sorensen, Signe, Goldberg, David M., and Dahle, Hakon
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Astrophysics - Cosmology and Extragalactic Astrophysics - Abstract
We report a mass reconstruction of A1689 using Particle Based Lensing (PBL), a new technique for Strong+Weak lensing that allows a variable resolution depending on the data density and the signal-to-noise. Using PBL we also calculate the covariance matrix for the resulting mass map. The reconstruction of A1689 shows a secondary mass peak in the north-east direction confirming previous optical observations. This indicates that the central region of the cluster is still undergoing a weak merger. We have used this mass map to measure power ratios of the dark matter distribution and compared it to the X-ray distribution. We find that the power in the X-ray distribution is lower suggesting a smoother and rounder gas distribution compared to the dark matter distribution. We fitted an NFW profile to the profile derived from the mass map and we find that the lensing mass within 1 Mpc is $1.5\pm0.33\times 10^{15}M_\odot$. This is higher than the X-ray mass., Comment: submitted to APJ. 21 pages, 6 figures
- Published
- 2012
35. X-ray, lensing and Sunyaev Zel'dovich triaxial analysis of Abell 1835 out to R_{200}
- Author
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Morandi, Andrea, Limousin, Marceau, Sayers, Jack, Golwala, Sunil R., Czakon, Nicole G., Pierpaoli, Elena, Jullo, Eric, Richard, Johan, and Ameglio, Silvia
- Subjects
Astrophysics - Cosmology and Nongalactic Astrophysics - Abstract
Measuring the intrinsic shape and orientation of dark matter (DM) and intracluster (IC) gas in galaxy clusters is crucial to constraining their formation and evolution, and for enhancing the use of clusters as more precise cosmological probes. Extending our previous works, we present for the first time results from a triaxial joint analysis of the galaxy cluster Abell 1835, by means of X-ray, strong lensing (SL) and Sunyaev Zel'dovich (SZ) data. We parametrically reconstruct the full three-dimensional structure (triaxial shape and principal axis orientation) of both the DM and the IC gas, and the level of non-thermal pressure of the IC gas. We find that the intermediate-major and minor-major axis ratios of the DM are 0.71+/-0.08 and 0.59+/-0.05, respectively, and the major axis of the DM halo is inclined with respect to the line of sight at 18.3+/-5.2 deg. We present the first observational measurement of the non-thermal pressure out to R_{200}, which has been evaluated to be a few percent of the total energy budget in the internal regions, while reaching approximately 20% in the outer volumes. We discuss the implications of our method for the viability of the CDM scenario, focusing on the concentration parameter C and the inner slope of the DM gamma in order to test the cold dark matter (CDM) paradigm for structure formation: we measure gamma=1.01+/-0.06 and C=4.32+/-0.44, values which are close to the predictions of the CDM model. The combination of X-ray/SL data at high spatial resolution, capable of resolving the cluster core, with the SZ data, which are more sensitive to the cluster outer volume, allows us to characterize the level and the gradient of the gas entropy distribution and non-thermal pressure out to R_{200}, breaking the degeneracy among the physical models describing the thermal history of the ICM., Comment: MNRAS in press. arXiv admin note: substantial text overlap with arXiv:1108.0769
- Published
- 2011
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36. Cluster-Cluster Lensing and the Case of Abell 383
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Zitrin, Adi, Rephaeli, Yoel, Sadeh, Sharon, Medezinski, Elinor, Umetsu, Keiichi, Sayers, Jack, Nonino, Mario, Morandi, Andrea, Molino, Alberto, Czakon, Nicole, and Golwala, Sunil R.
- Subjects
Astrophysics - Cosmology and Extragalactic Astrophysics - Abstract
Extensive surveys of galaxy clusters motivate us to assess the likelihood of cluster-cluster lensing (CCL), namely, gravitational-lensing of a background cluster by a foreground cluster. We briefly describe the characteristics of CCLs in optical, X-ray and SZ measurements, and calculate their predicted numbers for $\Lambda$CDM parameters and a viable range of cluster mass functions and their uncertainties. The predicted number of CCLs in the strong-lensing regime varies from several ($<10$) to as high as a few dozen, depending mainly on whether lensing triaxiality bias is accounted for, through the c-M relation. A much larger number is predicted when taking into account also CCL in the weak-lensing regime. In addition to few previously suggested CCLs, we report a detection of a possible CCL in A383, where background candidate high-$z$ structures are magnified, as seen in deep Subaru observations., Comment: 9 pages, 5 figures, submitted to MNRAS
- Published
- 2011
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37. Triaxiality, principal axis orientation and non-thermal pressure in Abell 383
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Morandi, Andrea and Limousin, Marceau
- Subjects
Astrophysics - Cosmology and Nongalactic Astrophysics - Abstract
While clusters of galaxies are regarded as one of the most important cosmological probes, the conventional spherical modeling of the intracluster medium (ICM) and the dark matter (DM), and the assumption of strict hydrostatic equilibrium (i.e., the equilibrium gas pressure is provided entirely by thermal pressure) are very approximate at best. Extending our previous works, we developed further a method to reconstruct for the first time the full three-dimensional structure (triaxial shape and principal axis orientation) of both DM and intracluster (IC) gas, and the level of non-thermal pressure of the IC gas. We outline an application of our method to the galaxy cluster Abell 383, taken as part of the CLASH multi-cycle treasury program, presenting results of a joint analysis of X-ray and strong lensing measurements. We find that the intermediate-major and minor-major axis ratios of the DM are 0.71+/-0.10 and 0.55+/-0.06, respectively, and the major axis of the DM halo is inclined with respect to the line of sight of 21.1+/-10.1 deg. The level of non-thermal pressure has been evaluated to be about 10% of the total energy budget. We discuss the implications of our method for the viability of the CDM scenario, focusing on the concentration parameter C and the inner slope of the DM gamma, since the cuspiness of dark-matter density profiles in the central regions is one of the critical tests of the cold dark matter (CDM) paradigm for structure formation: we measure gamma=1.02+/-0.06 on scales down to 25 Kpc, and C=4.76+/-0.51, values which are close to the predictions of the standard model, and providing further evidences that support the CDM scenario. Our method allows us to recover the three-dimensional physical properties of clusters in a bias-free way, overcoming the limitations of the standard spherical modelling and enhancing the use of clusters as more precise cosmological probes., Comment: MNRAS in press
- Published
- 2011
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38. Prediction for the neutrino mass in the KATRIN experiment from lensing by the galaxy cluster A1689
- Author
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Nieuwenhuizen, Theo M. and Morandi, Andrea
- Subjects
Astrophysics - Cosmology and Extragalactic Astrophysics ,High Energy Physics - Phenomenology - Abstract
The KATRIN experiment in Karlsruhe Germany will monitor the decay of tritium, which produces an electron-antineutrino. While the present upper bound for its mass is 2 eV/$c^2$, KATRIN will search down to 0.2 eV$/c^2$. If the dark matter of the galaxy cluster Abell 1689 is modeled as degenerate isothermal fermions, the strong and weak lensing data may be explained by degenerate neutrinos with mass of 1.5 eV$/c^2$. Strong lensing data beyond 275 kpc put tension on the standard cold dark matter interpretation. In the most natural scenario, the electron antineutrino will have a mass of 1.5 eV/$c^2$, a value that will be tested in KATRIN., Comment: 13 pages, 5 figures
- Published
- 2011
39. Triaxiality and non-thermal gas pressure in Abell 1689
- Author
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Morandi, Andrea, Limousin, Marceau, Rephaeli, Yoel, Umetsu, Keiichi, Barkana, Rennan, Broadhurst, Tom, and Dahle, Haakon
- Subjects
Astrophysics - Cosmology and Nongalactic Astrophysics - Abstract
Clusters of galaxies are uniquely important cosmological probes of the evolution of the large scale structure, whose diagnostic power depends quite significantly on the ability to reliably determine their masses. Clusters are typically modeled as spherical systems whose intracluster gas is in strict hydrostatic equilibrium (i.e., the equilibrium gas pressure is provided entirely by thermal pressure), with the gravitational field dominated by dark matter, assumptions that are only rough approximations. In fact, numerical simulations indicate that galaxy clusters are typically triaxial, rather than spherical, and that turbulent gas motions (induced during hierarchical merger events) provide an appreciable pressure component. Extending our previous work, we present results of a joint analysis of X-ray, weak and strong lensing measurements of Abell 1689. The quality of the data allows us to determine both the triaxial shape of the cluster and the level of non-thermal pressure that is required if the intracluster gas is in hydrostatic equilibrium. We find that the dark matter axis ratios are 1.24 +/- 0.13 and 2.02 +/- 0.01 on the plane of the sky and along the line of sight, respectively, and that about 20% of the pressure is non-thermal. Our treatment demonstrates that the dynamical properties of clusters can be determined in a (mostly) bias-free way, enhancing the use of clusters as more precise cosmological probes., Comment: Accepted for publication in MNRAS
- Published
- 2011
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40. Studying cosmic reionization with observations of the global 21-cm signal
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Morandi, Andrea and Barkana, Rennan
- Subjects
Astrophysics - Cosmology and Nongalactic Astrophysics - Abstract
We explore the ability of observations of the global brightness temperature of the 21-cm signal to constrain the reionization history and the properties of the ionizing sources. In order to describe the reionization signal, we employ either a commonly-used toy model or a structure formation model that parameterizes the properties of the ionizing sources. If the structure formation model captures the actual evolution of the reionization signal, then detecting the signal is somewhat easier than it would be for the toy model; using the toy model in this case also leads to systematic errors in reconstructing the reionization history, though a sufficiently sensitive experiment should be able to distinguish between the two models. We show that under optimistic assumptions regarding systematic noise and foreground removal, one-year observations of the global 21-cm spectrum should be able to detect a wide range of realistic models and measure the main features of the reionization history while constraining the key properties of the ionizing sources., Comment: MNRAS in press
- Published
- 2011
- Full Text
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41. Reconstructing the triaxiality of the galaxy cluster Abell 1689: solving the X-ray and strong lensing mass discrepancy
- Author
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Morandi, Andrea, Pedersen, Kristian, and Limousin, Marceau
- Subjects
Astrophysics - Cosmology and Nongalactic Astrophysics - Abstract
We present the first determination of the intrinsic triaxial shapes and tree-dimensional physical parameters of both dark matter (DM) and intra-cluster medium (ICM) for the galaxy cluster Abell 1689. We exploit the novel method we recently introduced (Morandi et al. 2010) in order to infer the tree-dimensional physical properties in triaxial galaxy clusters by combining jointly X-ray and strong lensing data. We find that Abell 1689 can be modeled as a triaxial galaxy cluster with DM halo axial ratios 1.24 +/- 0.13 and 2.37 +/- 0.11 on the plane of the sky and along the line of sight, respectively. We show that accounting for the three-dimensional geometry allows to solve the discrepancy between the mass determined from X-ray and strong gravitational lensing observations. We also determined the inner slope of the DM density profile alpha: we measure alpha = 0.90 +/- 0.05 by accounting explicitly for the 3D structure for this cluster, a value which is close to the cold dark matter (CDM) predictions, while the standard spherical modeling leads to the biased value alpha = 1.16 +/- 0.04. Our findings dispel the potential inconsistencies arisen in the literature between the predictions of the CDM scenario and the observations, providing further evidences that support the CDM scenario., Comment: Accepted for publication in ApJ
- Published
- 2010
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42. Measuring dark matter ellipticity of Abell 901/902 using Particle Based Lensing
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Deb, Sanghamitra, Goldberg, David M., Heymans, Catherine, and Morandi, Andrea
- Subjects
Astrophysics - Cosmology and Nongalactic Astrophysics - Abstract
We present a non-parametric measure of the ellipticity and the alignment of the dark matter halos in Abell 901/902 supercluster. This super-cluster is a system of four separate peaks in a $0.5^{\circ}\times0.5^{\circ}$ field of view. We map the mass distribution of each individual peak using an improved version of Particle Based Lensing (PBL) and measure the ellipticity of the dark matter halos associated with two of the peaks directly from the mass map and by fitting them to a singular isothermal ellipse. The parametric and non-parametric measurements are consistent for A901b while the position angle for the Southwest Group is different for the two techniques. We account for this discrepancy to substructure present in the Southwest Peak. We estimate an axis ratio of $0.37\pm 0.1$ for A901b and $0.54^{+0.08}_{-0.09}$ for the Southwest Group., Comment: submitted to APJ, 25 pages, 13 figures
- Published
- 2009
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43. Metabolic reprogramming in Nrf2-driven proliferation of normal rat hepatocytes
- Author
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Kowalik, Marta Anna, primary, Taguchi, Keiko, additional, Serra, Marina, additional, Caddeo, Andrea, additional, Puliga, Elisabetta, additional, Bacci, Marina, additional, Koshiba, Seizo, additional, Inoue, Jin, additional, Hishinuma, Eiji, additional, Morandi, Andrea, additional, Giordano, Silvia, additional, Perra, Andrea, additional, Yamamoto, Masayuki, additional, and Columbano, Amedeo, additional
- Published
- 2023
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44. Measurement of the dark matter velocity anisotropy in galaxy clusters
- Author
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Host, Ole, Hansen, Steen H., Piffaretti, Rocco, Morandi, Andrea, Ettori, Stefano, Kay, Scott T., and Valdarnini, Riccardo
- Subjects
Astrophysics - Abstract
The internal dynamics of a dark matter structure may have the remarkable property that the local temperature in the structure depends on direction. This is parametrized by the velocity anisotropy beta which must be zero for relaxed collisional structures, but has been shown to be non-zero in numerical simulations of dark matter structures. Here we present a method to infer the radial profile of the velocity anisotropy of the dark matter halo in a galaxy cluster from X-ray observables of the intracluster gas. This non-parametric method is based on a universal relation between the dark matter temperature and the gas temperature which is confirmed through numerical simulations. We apply this method to observational data and we find that beta is significantly different from zero at intermediate radii. Thus we find a strong indication that dark matter is effectively collisionless on the dynamical time-scale of clusters, which implies an upper limit on the self-interaction cross-section per unit mass sigma/m < 1 cm2/g. Our results may provide an independent way to determine the stellar mass density in the central regions of a relaxed cluster, as well as a test of whether a cluster is in fact relaxed., Comment: 10 pages, 8 figures, submitted to ApJ
- Published
- 2008
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45. Spontaneous Parametric Down-Conversion from GaAs Nanowires at Telecom Wavelength
- Author
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Saerens Grégoire, Duong Ngoc My Hanh, Solntsev Alexander S., Karvounis Artemios, Dursap Thomas, Regreny Philippe, Morandi Andrea, Chapman Robert J., Maeder Andreas, Danescu Alexandre, Penuelas José, Chauvin Nicolas, and Grange Rachel
- Subjects
Physics ,QC1-999 - Abstract
We report on the generation of photon pairs at 1550 nm from free-standing epitaxially grown self-assisted micrometre long GaAs nanowires. The efficiency of the spontaneous parametric down-conversion process has a rate of 320 GHz/Wm normalized to the transmission of the setup, the pump intensity, and the volume of the nanostructure. GaAs is a high index dielectric that can support electromagnetic Mie modes, therefore we model how shorter nanowires could improve the second-harmonic signal and we found that sub-micro long nanowires (600 nm length and 250 nm diameter) can support quality factors up to 15 at the pump wavelength (780 nm). We anticipate that the near field enhancement compared to micrometre long nanowires will boost the second-harmonic generation and, correspondingly, the biphoton rate efficiency.
- Published
- 2022
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46. Safety profile of cyclin-dependent kinase (CDK) 4/6 inhibitors with concurrent radiation therapy:A systematic review and meta-analysis
- Author
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Becherini, Carlotta, Visani, Luca, Caini, Saverio, Bhattacharya, Indrani S., Kirby, Anna M., Nader Marta, Gustavo, Morgan, Gilberto, Salvestrini, Viola, Coles, Charlotte E., Cortes, Javier, Curigliano, Giuseppe, de Azambuja, Evandro, Harbeck, Nadia, Isacke, Clare M., Kaidar-Person, Orit, Marangoni, Elisabetta, Offersen, Birgitte, Rugo, Hope S., Morandi, Andrea, Lambertini, Matteo, Poortmans, Philip, Livi, Lorenzo, and Meattini, Icro
- Subjects
CDK4/6 inhibitors ,Meta-analysis ,Breast cancer ,Radiotherapy ,Toxicity ,Systematic review - Abstract
The cyclin-dependent kinase 4 and 6 inhibitors (CDK4/6i) have become the standard of care for hormone receptor-positive (HR + ) and human epidermal growth factor receptor 2-negative (HER2-) metastatic breast cancer, improving survival outcomes compared to endocrine therapy alone. Abemaciclib and ribociclib, in combination with endocrine therapy, have demonstrated significant benefits in invasive disease-free survival for high-risk HR+/HER2- early breast cancer patients. Each CDK4/6i—palbociclib, ribociclib, and abemaciclib—exhibits distinct toxicity profiles. Radiation therapy (RT) can be delivered with a palliative or ablative intent, particularly using stereotactic body radiation therapy for oligometastatic or oligoprogressive disease. However, pivotal randomized trials lack information on concomitant CDK4/6i and RT, and existing preclinical and clinical data on the potential combined toxicities are limited and conflicting. As part of a broader effort to establish international consensus recommendations for integrating RT and targeted agents in breast cancer treatment, we conducted a systematic review and meta-analysis to evaluate the safety profile of combining CDK4/6i with palliative and ablative RT in both metastatic and early breast cancer settings.
- Published
- 2023
47. Cancer-associated fibroblasts promote prostate cancer malignancy via metabolic rewiring and mitochondrial transfer
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Ippolito, Luigi, Morandi, Andrea, Taddei, Maria Letizia, Parri, Matteo, Comito, Giuseppina, Iscaro, Alessandra, Raspollini, Maria Rosaria, Magherini, Francesca, Rapizzi, Elena, Masquelier, Julien, Muccioli, Giulio G., Sonveaux, Pierre, Chiarugi, Paola, and Giannoni, Elisa
- Published
- 2019
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48. Lithium Niobate on Insulator Photonic Networks as an Integrated Multiple Scattering Platform
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Wang, Xiyue Sissi, primary, Savo, Romolo, additional, Maeder, Andreas, additional, Kaufmann, Fabian, additional, Kellner, Jost, additional, Morandi, Andrea, additional, Rotter, Stefan, additional, Sapienza, Riccardo, additional, and Grange, Rachel, additional
- Published
- 2023
- Full Text
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49. Background-Free Near-Infrared Biphoton Emission from Single GaAs Nanowires
- Author
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Saerens, Grégoire, primary, Dursap, Thomas, additional, Hesner, Ian, additional, Duong, Ngoc M. H., additional, Solntsev, Alexander S., additional, Morandi, Andrea, additional, Maeder, Andreas, additional, Karvounis, Artemios, additional, Regreny, Philippe, additional, Chapman, Robert J., additional, Danescu, Alexandre, additional, Chauvin, Nicolas, additional, Penuelas, José, additional, and Grange, Rachel, additional
- Published
- 2023
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50. Pre-historic (
- Author
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Morandi, Andrea, Di Muro, Andrea, Principe, Claudia, Michon, Laurent, Leroi, Gabrielle, Norelli, Francesco, Bachèlery, Patrick, Cimarelli, Corrado, Series editor, Müller, Sebastian, Series editor, Bachelery, Patrick, editor, Lenat, Jean-François, editor, Di Muro, Andrea, editor, and Michon, Laurent, editor
- Published
- 2016
- Full Text
- View/download PDF
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