1. Molecular Mechanisms of Dentine-Pulp Complex Response Induced by Microbiome of Deep Caries
- Author
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Șachir Erdoğan, Mitran Loredana, Moraru Iren, Iliescu Andrei, Scărlătescu Sînziana, Mitran Mihai, Paula Perlea, Iliescu Alexandru-Andrei, and Gheorghiu Irina-Maria
- Subjects
0301 basic medicine ,deep caries ,business.industry ,molecular signals ,microbiome ,030206 dentistry ,General Biochemistry, Genetics and Molecular Biology ,Microbiology ,03 medical and health sciences ,stomatognathic diseases ,030104 developmental biology ,0302 clinical medicine ,tertiary dentine ,stomatognathic system ,Medicine ,Pulp (tooth) ,Microbiome ,business - Abstract
Deep caries progress is associated with tertiary dentin formation and additional reversible or irreversible dental pulp inflammation. It seems that some particular signs of pain in irreversible pulpitis are associated to a particular caries microflora. Streptococcus species, Parvimonas micra and Dialister invisus are prevailing in cases of throbbing pain while Streptococcus mutans is incriminated in sensitivity to vertical percussion of tooth. Continuous pain is thought to be the clinical outcome of Lactobacillus implication. A better understanding of molecular signals and mechanisms induced by microbiome of deep caries that orchestrate the modulation of dental pulp complex response toward tertiary dentinogenesis or pulp inflammation it is supposed to improve diagnosis and conservative therapies of vital pulp.
- Published
- 2019