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9. Volumetry in the Assessment of Pituitary Adenoma Resection: Endoscopy versus Microscopy

Author

Wang, Anthony C, Shah, Ashish H, Sidani, Charif, Gaynor, Brandon G, Dockrell, Simon, Burks, S Shelby, Sargi, Zoukaa B, Casiano, Roy R, and Morcos, Jacques J

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Cancer, Brain Disorders, Clinical Research, pituitary adenoma, volumetry, endoscopy, microscopy, Neurology & Neurosurgery, Dentistry
Abstract

Background  Assessment of the extent of resection after surgical resection of pituitary adenomas is most commonly reported in terms of the presence or absence of residual tumor. A quantitative comparison of volumetric resection between endonasal endoscopy (EE) and microsurgery (MS) has rarely been done. Methods  A retrospective analysis was performed on a consecutive series of 154 patients with pituitary adenomas treated by the same surgeon at a single institution. We employed volumetric analysis pre- and postoperatively on two cohorts of pituitary adenoma patients treated through MS ( n  = 37) versus EE approach ( n  = 117). Results  Volumetric analysis revealed a higher incidence of complete resection (64.4 vs. 56.8%) and mean volume reduction in the EE cohort (92.7 vs. 88.4%), although not significant. Recurrence rates were significantly lower in the EE group (7.7% vs 24.3%, p  = 0.015). Subgroup analysis identified that patients with preoperative tumor volumes >1 mL were less likely to recur through EE (7.8 vs. MS: 29.6%; p  = 0.0063). A higher incidence of complete resection was also noted in patients with favorable Knosp grades (0-1) (EE: 87.8 vs. MS: 63.2%; p  = 0.036). Postoperative complication rates were not significantly different between both techniques. Conclusion  Both microscopy and endoscopy are well-tolerated, effective approaches in the treatment of pituitary adenomas. Our series demonstrated that EE may be superior to MS in preventing tumor recurrence and achieving a complete resection in certain subsets of patients. EE provides a slight advantage in tumor control outcomes that may justify the paradigm shift to pure endoscopy at our center.

Published
2018

11. Microsurgical Resection of Brainstem Cavernomas: A Systematic Review and Meta-Analysis of Complications and Outcomes

Author

Albalkhi, Ibrahem, additional, Shafqat, Areez, additional, Bin-Alamer, Othman, additional, Mallela, Arka N., additional, Kuminkoski, Chloe, additional, Labib, Mohamed A., additional, Lang, Michael J., additional, Lawton, Michael T., additional, Morcos, Jacques J., additional, Couldwell, William T., additional, and Abou-Al-Shaar, Hussam, additional

Published
2024
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12. User’s Behavior in Digital Libraries: Process Mining Exploration

Author

Trabelsi, Marwa, Suire, Cyrille, Morcos, Jacques, Champagnat, Ronan, Goos, Gerhard, Founding Editor, Hartmanis, Juris, Founding Editor, Bertino, Elisa, Editorial Board Member, Gao, Wen, Editorial Board Member, Steffen, Bernhard, Editorial Board Member, Woeginger, Gerhard, Editorial Board Member, Yung, Moti, Editorial Board Member, Doucet, Antoine, editor, Isaac, Antoine, editor, Golub, Koraljka, editor, Aalberg, Trond, editor, and Jatowt, Adam, editor

Published
2019
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16. Table S3 from Cotargeting Phosphoinositide 3-Kinase and Focal Adhesion Kinase Pathways Inhibits Proliferation of NF2 Schwannoma Cells

Author

Hardin, Haley M., primary, Dinh, Christine T., primary, Huegel, Julianne, primary, Petrilli, Alejandra M., primary, Bracho, Olena, primary, Allaf, Abdulrahman M., primary, Karajannis, Matthias A., primary, Griswold, Anthony J., primary, Ivan, Michael E., primary, Morcos, Jacques, primary, Gultekin, Sakir H., primary, Telischi, Fred F., primary, Liu, Xue Zhong, primary, and Fernandez-Valle, Cristina, primary

Published
2023
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17. Figure S2 from Cotargeting Phosphoinositide 3-Kinase and Focal Adhesion Kinase Pathways Inhibits Proliferation of NF2 Schwannoma Cells

Author

Hardin, Haley M., primary, Dinh, Christine T., primary, Huegel, Julianne, primary, Petrilli, Alejandra M., primary, Bracho, Olena, primary, Allaf, Abdulrahman M., primary, Karajannis, Matthias A., primary, Griswold, Anthony J., primary, Ivan, Michael E., primary, Morcos, Jacques, primary, Gultekin, Sakir H., primary, Telischi, Fred F., primary, Liu, Xue Zhong, primary, and Fernandez-Valle, Cristina, primary

Published
2023
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18. Western Blot Raw Images and Quantification from Cotargeting Phosphoinositide 3-Kinase and Focal Adhesion Kinase Pathways Inhibits Proliferation of NF2 Schwannoma Cells

Author

Hardin, Haley M., primary, Dinh, Christine T., primary, Huegel, Julianne, primary, Petrilli, Alejandra M., primary, Bracho, Olena, primary, Allaf, Abdulrahman M., primary, Karajannis, Matthias A., primary, Griswold, Anthony J., primary, Ivan, Michael E., primary, Morcos, Jacques, primary, Gultekin, Sakir H., primary, Telischi, Fred F., primary, Liu, Xue Zhong, primary, and Fernandez-Valle, Cristina, primary

Published
2023
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19. Step-by-Step Dissection of the Extreme Lateral Transodontoid Approach to the Anterior Craniovertebral Junction: Surgical Anatomy and Technical Nuances

Author

Abramov, Irakliy, primary, Labib, Mohamed A., additional, Altshuler, David, additional, Houlihan, Lena Mary, additional, Gonzalez-Romo, Nicolas I., additional, Luther, Evan, additional, Ivan, Michael E., additional, Lawton, Michael T., additional, Morcos, Jacques J., additional, and Preul, Mark C., additional

Published
2023
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20. Data from Cotargeting Phosphoinositide 3-Kinase and Focal Adhesion Kinase Pathways Inhibits Proliferation of NF2 Schwannoma Cells

Author

Hardin, Haley M., primary, Dinh, Christine T., primary, Huegel, Julianne, primary, Petrilli, Alejandra M., primary, Bracho, Olena, primary, Allaf, Abdulrahman M., primary, Karajannis, Matthias A., primary, Griswold, Anthony J., primary, Ivan, Michael E., primary, Morcos, Jacques, primary, Gultekin, Sakir H., primary, Telischi, Fred F., primary, Liu, Xue Zhong, primary, and Fernandez-Valle, Cristina, primary

Published
2023
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21. Supplementary Data Legends from Cotargeting Phosphoinositide 3-Kinase and Focal Adhesion Kinase Pathways Inhibits Proliferation of NF2 Schwannoma Cells

Author

Hardin, Haley M., primary, Dinh, Christine T., primary, Huegel, Julianne, primary, Petrilli, Alejandra M., primary, Bracho, Olena, primary, Allaf, Abdulrahman M., primary, Karajannis, Matthias A., primary, Griswold, Anthony J., primary, Ivan, Michael E., primary, Morcos, Jacques, primary, Gultekin, Sakir H., primary, Telischi, Fred F., primary, Liu, Xue Zhong, primary, and Fernandez-Valle, Cristina, primary

Published
2023
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23. “Surgery is Art. You Should be One of the Artists” Juha Hernesniemi (1947–2023)

Author

Ramirez, Manuel Encarnacion, primary, Türe, Uğur, additional, Güngör, Abuzer, additional, Nurmukhametov, Renat, additional, Campero, Alvaro, additional, Baldoncini, Matias, additional, Kaprovoy, Stanislav, additional, Konovalov, Nikolay, additional, Mura, Jorge, additional, Lawton, Michael T., additional, Montemurro, Nicola, additional, and Morcos, Jacques J., additional

Published
2023
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31. Transcavernous Approach via Eyebrow Incision for Radiation Induced Medial Temporal Lobe Cavernoma: Two-Dimensional Operative Video.

Author

Wu, Eva M and Morcos, Jacques J

Subjects
*EYEBROWS, *TEMPORAL lobe, *CUSHING'S syndrome, *RADIATION
Abstract

We present a 31-year-old female with Cushing's disease treated with endoscopic endonasal resection followed by proton-beam radiation. She developed radiation-induced carotid stenosis and required a STA to MCA bypass. She presented years later with an ipsilateral radiation-induced medial temporal lobe cavernoma. Given her history of bypass, a cranioorbital approach could not be used. We demonstrate a step-by-step surgical technique of resection of a medial temporal lobe cavernoma through an eyebrow approach.By Eva M Wu and Jacques J MorcosReported by Author; Author [Extracted from the article]

Published
2024
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34. Long-term Functional Outcomes and Complications of Microsurgical Resection of Brainstem Cavernous Malformations: A Systematic Review and Meta-analysis

Author

Albalkhi, Ibrahem, primary, Shafqat, Areez, additional, Bin-Alamer, Othman, additional, Mallela, Arka N., additional, Kuminkoski, Chloe, additional, Labib, Mohamed A., additional, Lang, Michael J., additional, Lawton, Michael T., additional, Morcos, Jacques J., additional, Couldwell, William T., additional, and Abou-Al-Shaar, Hussam, additional

Published
2023
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35. Cotargeting Phosphoinositide 3-Kinase and Focal Adhesion Kinase Pathways Inhibits Proliferation of NF2 Schwannoma Cells

Author

Hardin, Haley M., primary, Dinh, Christine T., additional, Huegel, Julianne, additional, Petrilli, Alejandra M., additional, Bracho, Olena, additional, Allaf, Abdulrahman M., additional, Karajannis, Matthias A., additional, Griswold, Anthony J., additional, Ivan, Michael E., additional, Morcos, Jacques, additional, Gultekin, Sakir H., additional, Telischi, Fred F., additional, Liu, Xue Zhong, additional, and Fernandez-Valle, Cristina, additional

Published
2023
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48. Effect of AR42 in Primary Vestibular Schwannoma Cells and a Xenograft Model of Vestibular Schwannoma

Author

Misztal, Carly, Bracho, Olena, Bas, Esperanza, Estivill, Michael, Ivan, Michael E., Morcos, Jacques, Bhatia, Rita, Telischi, Fred, Liu, Xue-Zhong, Gultekin, Sakir H., Fernandez-Valle, Cristina, and Dinh, Christine T.

Subjects
Histone Deacetylase Inhibitors, Disease Models, Animal, Otorhinolaryngology, Animals, Heterografts, Humans, Neuroma, Acoustic, Schwann Cells, Neurology (clinical), Article, Sensory Systems, Rats
Abstract

HYPOTHESIS: AR42, a histone deacetylase (HDAC) inhibitor, reduces viability of primary vestibular schwannoma (VS) cells and delays tumor progression and hearing loss (HL) in a xenograft model of VS. BACKGROUND: The impact of HDAC expression on AR42 response in primary VS cells is unknown, as well as the effects of AR42 on VS-associated HL and imbalance. METHODS: Primary human VS cells (n=7) were treated with AR42 (0–3.0μM), and viability assays were conducted. Immunohistochemistry and western blotting for phosphorylated-HDAC2 (pHDAC2) were performed on tumor chunks. Pharmacokinetic studies were conducted in Fischer rats using mass spectrometry. Merlin-deficient Schwann cells were grafted onto cochleovestibular nerves of immunodeficient rats and treated with vehicle (n=7) or AR42 (25mg/kg/day for 4 weeks; n=12). Tumor bioluminescence imaging, auditory brainstem response (ABR), and rotarod tests were conducted to 6 weeks. Final tumor weight and toxicities were measured. RESULTS: AR42 caused dose-dependent reductions in viability of VS cells. Tumors with higher pHDAC2:HDAC2 ratios had greater reductions in viability with AR42. On pharmacokinetic studies, AR42 reached peak levels in nerve ~24 hours after oral administration. Although AR42-treated rats demonstrated mean ABR threshold shifts ~10–20 dB lower than controls, this did not persist nor reach significance. When compared to controls, AR42 did not affect tumor bioluminescence, tumor weight, and rotarod measurements. CONCLUSIONS: Response of primary VS cells to AR42 may be influenced by pHDAC2 expression in tumor. Although AR42 may delay HL in our xenograft model, it did not halt tumor growth or vestibular dysfunction. Further investigations are warranted to evaluate the AR42 effectiveness in NF2-associated VS.

Published
2022

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