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76 results on '"Mordacchini, C."'

13. Endoscopic resection followed by adjuvant radiotherapy for sinonasal intestinal-type adenocarcinoma: Retrospective analysis of 30 consecutive patients

Author

Antognoni, P, Turri-Zanoni, M, Gottardo, S, Molteni, M, Volpi, L, Facco, C, Freguia, S, Mordacchini, C, Alqahtani, A, Bignami, M, Capella, C, Castelnuovo, P, and TURRI ZANONI, Mario

Subjects
Adult, Male, Analysis of Variance, Endoscopy, Kaplan-Meier Estimate, Adenocarcinoma, Middle Aged, Combined Modality Therapy, Risk Assessment, Survival Analysis, Disease-Free Survival, Cohort Studies, Treatment Outcome, Intestinal Neoplasms, Multivariate Analysis, Humans, Female, Radiotherapy, Adjuvant, Neoplasm Recurrence, Local, Paranasal Sinus Neoplasms, Aged, Follow-Up Studies, Proportional Hazards Models, Retrospective Studies
Abstract

Intestinal-type adenocarcinoma (ITAC) is a rare and locally aggressive occupation-related tumor. Currently, endoscopic-assisted resection and advances in irradiation modalities (3D conformal radiotherapy/intensity-modulated radiation therapy [IMRT]) are emerging as an alternative to traditional open surgery and conventional radiotherapy.Retrospective analysis of 30 consecutive patients affected with sinonasal ITAC, primarily treated by an endoscopic approach followed by 3D conformal radiotherapy/IMRT at a single institution, from 2003 to 2010.The 5-year overall survival (OS), disease-specific survival (DSS), disease-free survival (DFS), and recurrence-free survival (RFS) were 72.7% ± 9.6%, 78% ± 9.5%, 67.9% ± 10.7%, and 69.2% ± 9.4%, respectively (mean follow-up, 48 months). No major complications or serious toxicities were observed. Prognostic factors were stage of disease at diagnosis, development of recurrences, status of surgical margins, grading, tumoral pattern of growth, and proliferative index (Ki-67).The low morbidity of endoscopic approaches, the acceptable toxicity of modern irradiation modalities, and these promising survival rates, indicate that this treatment strategy might be considered a safe, minimally invasive, and maximally effective option for treating selected sinonasal ITAC.

Published
2015

22. Dosimetria portale

Author

Stucchi, P., Conte, Leopoldo, and Mordacchini, C.

Published
2003

23. Fisica Medica

Author

Conte, Leopoldo and Mordacchini, C.

Published
2000

49. Correlation between dosimetrical data and rectal bleeding in radiotherapy of prostate cancer: A retrospective analysis

Author

Bianchi, C., Cattaneo, G. M., Cozzarini, C., Fiorino, C., Mordacchini, C., Piazzolla, A., Michele Reni, Vavassori, V., Bianchi, C, Cattaneo, Gm, Cozzarini, C, Fiorino, C, Mordacchini, C, Piazzolla, A, Reni, M, and Vavassori, V

Abstract

The purpose of current study is to search for possible correlation between dosimetry-clinical-technical parameters and late grade II/III rectum bleeding through a retrospective analysis of 175 patients (conformal: 115; non-conformal: 60) treated in the two Institutes for prostate carcinoma with curative or adjuvant intent (ICRU dose ranging from 60 to 76 Gy) in the years 1994-1998. The dose -volume-histograms (DVH) and dose statistics were collected together with a number of clinical and technical/dosimetry data. Mean, median and maximum dose and the fraction of rectum receiving more than 50, 55, 60, 65, 70 and 75 Gy were considered (V50,55,60,65,70,75). Rectal toxicity was scored through the RTOG/EORTC scale [1]: minimum follow-up was 15 months. 23/ 175 patients (13.1%) experienced grade II-III bleeding (grade III: 1/175). Posterior wall irradiation (more than 2 cm, 33% vs. 8.5%) and type of technique (conformal or not, 6% vs. 26%) were significantly correlated with the risk of grade II/III bleeding (p < 0.001. chi (2) test). When considering the greater than or equal to 70 Gy patients (n = 126) a number of constraints resulted to be significant (chi (2) test): mean dose ( greater than or equal to 57 Gy, p = 0.03); median dose ( greater than or equal to 64 Gy, p = 0.025); V70 ( greater than or equal to 35%, p = 0.025); V65 ( greater than or equal to 48%, p = 0.03) V50 ( greater than or equal to 69%, p = 0.04).

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