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483 results on '"Moreaux, Jérôme"'

7. An atlas of cells in the human tonsil

Author

Massoni-Badosa, Ramon, Aguilar-Fernández, Sergio, Nieto, Juan C., Soler-Vila, Paula, Elosua-Bayes, Marc, Marchese, Domenica, Kulis, Marta, Vilas-Zornoza, Amaia, Bühler, Marco Matteo, Rashmi, Sonal, Alsinet, Clara, Caratù, Ginevra, Moutinho, Catia, Ruiz, Sara, Lorden, Patricia, Lunazzi, Giulia, Colomer, Dolors, Frigola, Gerard, Blevins, Will, Romero-Rivero, Lucia, Jiménez-Martínez, Víctor, Vidal, Anna, Mateos-Jaimez, Judith, Maiques-Diaz, Alba, Ovejero, Sara, Moreaux, Jérôme, Palomino, Sara, Gomez-Cabrero, David, Agirre, Xabier, Weniger, Marc A., King, Hamish W., Garner, Lucy C., Marini, Federico, Cervera-Paz, Francisco Javier, Baptista, Peter M., Vilaseca, Isabel, Rosales, Cecilia, Ruiz-Gaspà, Silvia, Talks, Benjamin, Sidhpura, Keval, Pascual-Reguant, Anna, Hauser, Anja E., Haniffa, Muzlifah, Prosper, Felipe, Küppers, Ralf, Gut, Ivo Glynne, Campo, Elias, Martin-Subero, José Ignacio, and Heyn, Holger

Published
2024
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14. Combined inhibition of Wee1 and Chk1 as a therapeutic strategy in multiple myeloma

Author

Bruyer, Angélique, primary, Dutrieux, Laure, additional, de Boussac, Hugues, additional, Martin, Thibaut, additional, Chemlal, Djamila, additional, Robert, Nicolas, additional, Requirand, Guilhem, additional, Cartron, Guillaume, additional, Vincent, Laure, additional, Herbaux, Charles, additional, Lutzmann, Malik, additional, Bret, Caroline, additional, Pasero, Philippe, additional, Moreaux, Jérôme, additional, and Ovejero, Sara, additional

Published
2023
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16. Dihydropyrimidinase Protects from DNA Replication Stress Caused by Cytotoxic Metabolites

Author

Basbous, Jihane, primary, Aze, Antoine, primary, Chaloin, Laurent, primary, Lebdy, Rana, primary, Hodroj, Dana, primary, Ribeyre, Cyril, primary, Larroque, Marion, primary, Shepard, Caitlin, primary, Kim, Baek, primary, Pruvost, Alain, primary, Moreaux, Jérôme, primary, Maiorano, Domenico, primary, Mechali, Marcel, primary, and Constantinou, Angelos, primary

Published
2021
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17. Extreme thrombocytosis with an aggressive evolution harboring a novel variant of calreticulin (CALR) in exon 3.

Author

Bonnet, Sarah, Carillo, Serge, Legrand, Baptiste, Burroni, Barbara, Lavabre‐Bertrand, Thierry, Requirand, Guilhem, Robert, Nicolas, Fornero, Lea, Al Mansoori, Ahmed, Moreaux, Jérôme, Cartron, Guillaume, Gabellier, Ludovic, and Herbaux, Charles

Subjects
CALRETICULIN, THROMBOCYTOSIS, MYELOPROLIFERATIVE neoplasms, MYELODYSPLASTIC syndromes, MYELOID cells, MYELOFIBROSIS
Abstract

We describe the case of a patient with extreme thrombocytosis whose evolution was rapidly fatal. No cause of secondary thrombocytosis was found. There was no sign of myelofibrosis but the megakaryocytes were small and dysplastic. The patient presented a calreticulin (CALR) variant in exon 3 (C105S), as well as concomitant mutations of ASXL1, U2AF1, and EZH2. This variant of CALR has never been described before, and after sorting, all identified mutations were found in myeloid cells but not in lymphoid cells. Therefore, the diagnosis of a frontier case of myelodysplastic syndrome/myeloproliferative neoplasm (MDS/MPN) was made. A treatment with hydroxycarbamide was started because of a high risk of thrombosis. Upon worsening of the hematological status two new mutations appeared, SETBP1 and ETV6, and the CALR mutation was still detectable, as well as the three other mutations found in the chronic stage. Our results show that this variant could contribute to MDS/MPN pathogenesis in that patient. [ABSTRACT FROM AUTHOR]

Published
2024
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18. RNA-sequencing based first choice of treatment and determination of risk in multiple myeloma

Author

Emde-Rajaratnam, Martina, primary, Beck, Susanne, additional, Benes, Vladimir, additional, Salwender, Hans, additional, Bertsch, Uta, additional, Scheid, Christoph, additional, Hänel, Mathias, additional, Weisel, Katja, additional, Hielscher, Thomas, additional, Raab, Marc S., additional, Goldschmidt, Hartmut, additional, Jauch, Anna, additional, Maes, Ken, additional, De Bruyne, Elke, additional, Menu, Eline, additional, De Veirman, Kim, additional, Moreaux, Jérôme, additional, Vanderkerken, Karin, additional, Seckinger, Anja, additional, and Hose, Dirk, additional

Published
2023
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22. Figure S1 from Extracellular S100A9 Protein in Bone Marrow Supports Multiple Myeloma Survival by Stimulating Angiogenesis and Cytokine Secretion

Author

De Veirman, Kim, primary, De Beule, Nathan, primary, Maes, Ken, primary, Menu, Eline, primary, De Bruyne, Elke, primary, De Raeve, Hendrik, primary, Fostier, Karel, primary, Moreaux, Jérôme, primary, Kassambara, Alboukadel, primary, Hose, Dirk, primary, Heusschen, Roy, primary, Eriksson, Helena, primary, Vanderkerken, Karin, primary, and Van Valckenborgh, Els, primary

Published
2023
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23. Supplementary Table S3 from Discovery of Candidate DNA Methylation Cancer Driver Genes

Author

Pan, Heng, primary, Renaud, Loïc, primary, Chaligne, Ronan, primary, Bloehdorn, Johannes, primary, Tausch, Eugen, primary, Mertens, Daniel, primary, Fink, Anna Maria, primary, Fischer, Kirsten, primary, Zhang, Chao, primary, Betel, Doron, primary, Gnirke, Andreas, primary, Imielinski, Marcin, primary, Moreaux, Jérôme, primary, Hallek, Michael, primary, Meissner, Alexander, primary, Stilgenbauer, Stephan, primary, Wu, Catherine J., primary, Elemento, Olivier, primary, and Landau, Dan A., primary

Published
2023
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25. Data from Discovery of Candidate DNA Methylation Cancer Driver Genes

Author

Pan, Heng, primary, Renaud, Loïc, primary, Chaligne, Ronan, primary, Bloehdorn, Johannes, primary, Tausch, Eugen, primary, Mertens, Daniel, primary, Fink, Anna Maria, primary, Fischer, Kirsten, primary, Zhang, Chao, primary, Betel, Doron, primary, Gnirke, Andreas, primary, Imielinski, Marcin, primary, Moreaux, Jérôme, primary, Hallek, Michael, primary, Meissner, Alexander, primary, Stilgenbauer, Stephan, primary, Wu, Catherine J., primary, Elemento, Olivier, primary, and Landau, Dan A., primary

Published
2023
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27. Supplementary Data from Extracellular S100A9 Protein in Bone Marrow Supports Multiple Myeloma Survival by Stimulating Angiogenesis and Cytokine Secretion

Author

De Veirman, Kim, primary, De Beule, Nathan, primary, Maes, Ken, primary, Menu, Eline, primary, De Bruyne, Elke, primary, De Raeve, Hendrik, primary, Fostier, Karel, primary, Moreaux, Jérôme, primary, Kassambara, Alboukadel, primary, Hose, Dirk, primary, Heusschen, Roy, primary, Eriksson, Helena, primary, Vanderkerken, Karin, primary, and Van Valckenborgh, Els, primary

Published
2023
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33. Supplementary Table 1 from Extracellular S100A9 Protein in Bone Marrow Supports Multiple Myeloma Survival by Stimulating Angiogenesis and Cytokine Secretion

Author

De Veirman, Kim, primary, De Beule, Nathan, primary, Maes, Ken, primary, Menu, Eline, primary, De Bruyne, Elke, primary, De Raeve, Hendrik, primary, Fostier, Karel, primary, Moreaux, Jérôme, primary, Kassambara, Alboukadel, primary, Hose, Dirk, primary, Heusschen, Roy, primary, Eriksson, Helena, primary, Vanderkerken, Karin, primary, and Van Valckenborgh, Els, primary

Published
2023
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36. Data from Extracellular S100A9 Protein in Bone Marrow Supports Multiple Myeloma Survival by Stimulating Angiogenesis and Cytokine Secretion

Author

De Veirman, Kim, primary, De Beule, Nathan, primary, Maes, Ken, primary, Menu, Eline, primary, De Bruyne, Elke, primary, De Raeve, Hendrik, primary, Fostier, Karel, primary, Moreaux, Jérôme, primary, Kassambara, Alboukadel, primary, Hose, Dirk, primary, Heusschen, Roy, primary, Eriksson, Helena, primary, Vanderkerken, Karin, primary, and Van Valckenborgh, Els, primary

Published
2023
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37. Supplementary Data from Discovery of Candidate DNA Methylation Cancer Driver Genes

Author

Pan, Heng, primary, Renaud, Loïc, primary, Chaligne, Ronan, primary, Bloehdorn, Johannes, primary, Tausch, Eugen, primary, Mertens, Daniel, primary, Fink, Anna Maria, primary, Fischer, Kirsten, primary, Zhang, Chao, primary, Betel, Doron, primary, Gnirke, Andreas, primary, Imielinski, Marcin, primary, Moreaux, Jérôme, primary, Hallek, Michael, primary, Meissner, Alexander, primary, Stilgenbauer, Stephan, primary, Wu, Catherine J., primary, Elemento, Olivier, primary, and Landau, Dan A., primary

Published
2023
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39. Supplemental Table S3 from Loss of RASSF4 Expression in Multiple Myeloma Promotes RAS-Driven Malignant Progression

Author

De Smedt, Eva, primary, Maes, Ken, primary, Verhulst, Stefaan, primary, Lui, Hui, primary, Kassambara, Alboukadel, primary, Maes, Anke, primary, Robert, Nicolas, primary, Heirman, Carlo, primary, Cakana, Andrew, primary, Hose, Dirk, primary, Breckpot, Karine, primary, van Grunsven, Leo A., primary, De Veirman, Kim, primary, Menu, Eline, primary, Vanderkerken, Karin, primary, Moreaux, Jérôme, primary, and De Bruyne, Elke, primary

Published
2023
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40. Supplemental Figures S1-S7 from Loss of RASSF4 Expression in Multiple Myeloma Promotes RAS-Driven Malignant Progression

Author

De Smedt, Eva, primary, Maes, Ken, primary, Verhulst, Stefaan, primary, Lui, Hui, primary, Kassambara, Alboukadel, primary, Maes, Anke, primary, Robert, Nicolas, primary, Heirman, Carlo, primary, Cakana, Andrew, primary, Hose, Dirk, primary, Breckpot, Karine, primary, van Grunsven, Leo A., primary, De Veirman, Kim, primary, Menu, Eline, primary, Vanderkerken, Karin, primary, Moreaux, Jérôme, primary, and De Bruyne, Elke, primary

Published
2023
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41. Data from Loss of RASSF4 Expression in Multiple Myeloma Promotes RAS-Driven Malignant Progression

Author

De Smedt, Eva, primary, Maes, Ken, primary, Verhulst, Stefaan, primary, Lui, Hui, primary, Kassambara, Alboukadel, primary, Maes, Anke, primary, Robert, Nicolas, primary, Heirman, Carlo, primary, Cakana, Andrew, primary, Hose, Dirk, primary, Breckpot, Karine, primary, van Grunsven, Leo A., primary, De Veirman, Kim, primary, Menu, Eline, primary, Vanderkerken, Karin, primary, Moreaux, Jérôme, primary, and De Bruyne, Elke, primary

Published
2023
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42. Supplemental materials and methods, supplemental references and supplemental figure legends from Loss of RASSF4 Expression in Multiple Myeloma Promotes RAS-Driven Malignant Progression

Author

De Smedt, Eva, primary, Maes, Ken, primary, Verhulst, Stefaan, primary, Lui, Hui, primary, Kassambara, Alboukadel, primary, Maes, Anke, primary, Robert, Nicolas, primary, Heirman, Carlo, primary, Cakana, Andrew, primary, Hose, Dirk, primary, Breckpot, Karine, primary, van Grunsven, Leo A., primary, De Veirman, Kim, primary, Menu, Eline, primary, Vanderkerken, Karin, primary, Moreaux, Jérôme, primary, and De Bruyne, Elke, primary

Published
2023
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43. Supplemental Tables S1, S4 and S5 from Loss of RASSF4 Expression in Multiple Myeloma Promotes RAS-Driven Malignant Progression

Author

De Smedt, Eva, primary, Maes, Ken, primary, Verhulst, Stefaan, primary, Lui, Hui, primary, Kassambara, Alboukadel, primary, Maes, Anke, primary, Robert, Nicolas, primary, Heirman, Carlo, primary, Cakana, Andrew, primary, Hose, Dirk, primary, Breckpot, Karine, primary, van Grunsven, Leo A., primary, De Veirman, Kim, primary, Menu, Eline, primary, Vanderkerken, Karin, primary, Moreaux, Jérôme, primary, and De Bruyne, Elke, primary

Published
2023
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44. Immunophenotypic portrait of leukemia‐associated‐phenotypemarkers in B acute lymphoblastic leukemia

Author

Boris, Emilia, Theron, Alexandre, Montagnon, Valentin, Rouquier, Nicolas, Almeras, Marion, Moreaux, Jérôme, and Bret, Caroline

Abstract

Multiparametric flow cytometry (MFC) is an essential diagnostic tool in B acute lymphoblastic leukemia (B ALL) to determine the B‐lineage affiliation of the blast population and to define their complete immunophenotypic profile. Most MFC strategies used in routine laboratories include leukemia‐associated phenotype (LAP) markers, whose expression profiles can be difficult to interpret. The aim of our study was to reach a better understanding of 7 LAP markers' landscape in B ALL: CD9, CD21, CD66c, CD58, CD81, CD123, and NG2. Using a 10‐color MFC approach, we evaluated the level of expression of 7 LAP markers including CD9, CD21, CD66c, CD58, CD81, CD123, and NG2, at the surface of normal peripheral blood leukocytes (n= 10 healthy donors), of normal precursor B regenerative cells (n= 40 uninvolved bone marrow samples) and of lymphoblasts (n= 100 peripheral blood samples or bone marrow samples from B ALL patients at diagnosis). The expression profile of B lymphoblasts was analyzed according the presence or absence of recurrent cytogenetic aberrations. The prognostic value of the 7 LAP markers was examined using Maxstat R algorithm. In order to help the interpretation of the MFC data in routine laboratories, we first determined internal positive and negative populations among normal leukocytes for each of the seven evaluated LAP markers. Second, their profile of expression was evaluated in normal B cell differentiation in comparison with B lymphoblasts to establish a synopsis of their expression in normal hematogones. We then evaluated the frequency of expression of these LAP markers at the surface of B lymphoblasts at diagnosis of B ALL. CD9 was expressed in 60% of the cases, CD21 in only 3% of the cases, CD58 in 96% of the cases, CD66c in 45% of the cases, CD81 in 97% of the cases, CD123 in 72% of the cases, and NG2 in only 2% of the cases. We confirmed the interest of the CD81/CD58 MFI expression ratio as a way to discriminate hematogones from lymphoblasts. We observed a significant lower expression of CD9 and of CD81 at the surface of B lymphoblasts with a t(9;22)(BCR‐ABL) in comparison with B lymphoblasts without any recurrent cytogenetic alteration (p= 0.0317 and p= 0.0011, respectively) and with B lymphoblasts harboring other cytogenetic recurrent abnormalities (p= 0.0032 and p< 0.0001, respectively). B lymphoblasts with t(1;19) at diagnosis significantly overexpressed CD81 when compared with B lymphoblasts with other recurrent cytogenetic abnormalities or without any recurrent alteration (p= 0.0001). An overexpression of CD58 was also observed in the cases harboring this abnormal cytogenetic event, when compared with B lymphoblasts with other recurrent cytogenetic abnormalities (p= 0.030), or without any recurrent alteration (p= 0.0002). In addition, a high expression of CD123, of CD58 and of CD81 was associated with a favorable prognosis in our cohort of pediatric and young adult B ALL patients. We finally built a risk score based on the expression of these 3 LAP markers, this scoring approach being able to split these patients into a high‐risk group (17%) and a better outcome group (83%, p< 0.0001). The complexity of the phenotypic signature of lymphoblasts at diagnosis of B ALL is illustrated by the variability in the expression of LAP antigens. Knowledge of the expression levels of these markers in normal leukocytes and during normal B differentiation is crucial for an optimal interpretation of diagnostic cytometry results and serves as a basis for the biological follow‐up of B ALL.

Published
2024
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48. The BLM helicase is a new therapeutic target in multiple myeloma involved in replication stress survival and drug resistance

Author

Ovejero, Sara, primary, Viziteu, Elena, additional, Dutrieux, Laure, additional, Devin, Julie, additional, Lin, Yea-Lih, additional, Alaterre, Elina, additional, Jourdan, Michel, additional, Basbous, Jihane, additional, Requirand, Guilhem, additional, Robert, Nicolas, additional, de Boussac, Hugues, additional, Seckinger, Anja, additional, Hose, Dirk, additional, Vincent, Laure, additional, Herbaux, Charles, additional, Constantinou, Angelos, additional, Pasero, Philippe, additional, and Moreaux, Jérôme, additional

Published
2022
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49. Growth Factors in Multiple Myeloma

Author

Moreaux, Jérôme, Bret, Caroline, Mahtouk, Karène, Sprynski, Anne-Catherine, Hose, Dirk, Klein, Bernard, Munshi, Nikhil C., editor, and Anderson, Kenneth C., editor

Published
2013
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50. miRNA profile at diagnosis predicts treatment outcome in patients with B-chronic lymphocytic leukemia: A FILO study

Author

Duroux-Richard, Isabelle, primary, Gagez, Anne-Laure, additional, Alaterre, Elina, additional, Letestu, Rémi, additional, Khalifa, Olfa, additional, Jorgensen, Christian, additional, Leprêtre, Stéphane, additional, Tchernonog, Emmanuelle, additional, Moreaux, Jérôme, additional, Cartron, Guillaume, additional, and Apparailly, Florence, additional

Published
2022
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