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Your search keyword '"Moreira, Daniele Dal Col"' showing total 5 results
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5 results on '"Moreira, Daniele Dal Col"'

2. Vitis vinifera L. grape skin extract activates the insulin-signalling cascade and reduces hyperglycaemia in alloxan-induced diabetic mice

Author

Soares de Moura, Roberto, primary, da Costa, Giselle França, additional, Moreira, Annie Seixas Bello, additional, Queiroz, Emerson Ferreira, additional, Moreira, Daniele Dal Col, additional, Garcia-Souza, Erica Patrícia, additional, Resende, Ângela Castro, additional, Moura, Aníbal Sanchez, additional, and Teixeira, Michelle Teixeira, additional

Published
2011
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4. Vitis vinifera L. grape skin extract activates the insulin-signalling cascade and reduces hyperglycaemia in alloxan-induced diabetic mice.

Author

Soares de Moura, Roberto, da Costa, Giselle França, Moreira, Annie Seixas Bello, Queiroz, Emerson Ferreira, Moreira, Daniele Dal Col, Garcia-Souza, Erica Patrícia, Resende, Ângela Castro, Moura, Aníbal Sanchez, and Teixeira, Michelle Teixeira

Subjects
VITIS vinifera, LABORATORY mice, SERUM, INSULIN, ALLOXAN, DIABETES complications
Abstract

Objectives This study examined the effect of Vitis vinifera grape skin extract (ACH09) on hyperglycaemia and the insulin-signalling cascade in alloxan-treated mice. Methods Glycaemia, serum insulin and Western blot analysis of insulin cascade proteins were evaluated in the gastrocnemius muscles of four groups of adult mice: control, ACH09 (200 mg/kg per day, p.o.), alloxan (300 mg/kg, i.p.) and alloxan + ACH09. Insulin secretion in isolated pancreatic islets was also studied. Key findings Glycaemia values in the alloxan + ACH09 and ACH09 groups were significantly lower than in the alloxan-treated and control groups, respectively. Increased insulin resistance (HOMA index) was observed in the alloxan-treated group but not in the alloxan + ACH09 group. Insulin receptor content and Akt phosphorylation were significantly greater in the alloxan + ACH09 group compared with the alloxan-treated group. The glucose transporter (GLUT-4) content was reduced in alloxan-treated mice compared with the control group, while alloxan + ACH09 and ACH09-treated mice showed a significant increase in GLUT-4 content. ACH09 treatment did not change glucose-induced insulin secretion in isolated pancreatic islets. Conclusions The results suggest that ACH09 has hypoglycaemic and antihyperglycaemic effects that are independent of an increase in insulin release but are probably dependent on an increase in insulin sensitivity resulting from an activation of the insulin-signalling cascade in skeletal muscle. [ABSTRACT FROM AUTHOR]

Published
2012
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5. Metabolic Disorders and Oxidative Stress Programming in Offspring of Rats Fed a High-fat Diet During Lactation Effects of a ViniferaGrape Skin (ACH09) Extract

Author

Emiliano, Andréa Fernandes, Cavalho, Lenize Costa Reis Marins de, da Silva Cristino Cordeiro, Viviane, Costa, Cristiane Aguiar da, Oliveira, Paola Braz Raquel de, Queiroz, Emerson Ferreira, Moreira, Daniele Dal Col, Boaventura, Gilson Teles, Moura, Roberto Soares de, and Resende, Angela Castro

Abstract

This study examined the effect of Vitis viniferagrape skin ACH09 extract (ACH09) on metabolic disorders and oxidative stress in adult offspring of rats fed a high-fat diet (HF) during lactation. Four groups of female rats were fed: control diet (7% fat); ACH09 (7% fat + 200 mg·kg−1·d−1ACH09 orally); HF (24% fat); HF+ ACH09 (24% fat + 200 mg·kg−1·d−1ACH09 orally) during lactation. From weaning onward, all female offspring were fed a control diet and killed when they were 90 or 180 days old. Systolic blood pressure was increased in adult offspring of HF-fed dams, and ACH09 prevented hypertension. Increased adiposity, plasma triglyceride, glucose levels, and insulin resistance were observed in offspring from both ages, and these changes were reversed by ACH09. The plasma oxidative damage assessed by malondialdehyde levels was increased, and nitrite levels decreased in the HF group of both ages, which were reversed by ACH09. In addition, ACH09 restored the decreased plasma and mesenteric artery antioxidant activities of superoxide dismutase, catalase, and glutathione peroxidase in the HF group. In conclusion, ACH09 protected normally fed offspring of HF-fed dams during lactation from phenotypic and metabolic characteristics of metabolic syndrome providing an alternative nutritional resource for the prevention of metabolic syndrome.

Published
2011
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