27 results on '"Moreira, Filipe Romero Rebello"'
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2. Lessons from a Multilaboratorial Task Force for Diagnosis of a Fatal Toxoplasmosis Outbreak in Captive Primates in Brazil
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Schiffler, Francine Bittencourt, primary, Pereira, Asheley Henrique Barbosa, additional, Moreira, Silvia Bahadian, additional, Arruda, Igor Falco, additional, Moreira, Filipe Romero Rebello, additional, D’arc, Mirela, additional, Claro, Ingra Morales, additional, Pissinatti, Thalita de Abreu, additional, Cavalcante, Liliane Tavares de Faria, additional, Miranda, Thamiris dos Santos, additional, Cosentino, Matheus Augusto Calvano, additional, de Oliveira, Renata Carvalho, additional, Fernandes, Jorlan, additional, Assis, Matheus Ribeiro da Silva, additional, de Oliveira, Jonathan Gonçalves, additional, da Silva, Thayssa Alves Coelho, additional, Galliez, Rafael Mello, additional, Faffe, Debora Souza, additional, de Jesus, Jaqueline Goes, additional, Sobreira Bezerra da Silva, Marise, additional, Bezerra, Matheus Filgueira, additional, Ferreira Junior, Orlando da Costa, additional, Tanuri, Amilcar, additional, Castiñeiras, Terezinha Marta, additional, Aguiar, Renato Santana, additional, Faria, Nuno Rodrigues, additional, Almeida, Alzira Paiva de, additional, Pissinatti, Alcides, additional, Sabino, Ester Cerdeira, additional, Amendoeira, Maria Regina Reis, additional, de Lemos, Elba Regina Sampaio, additional, Ubiali, Daniel Guimarães, additional, and Santos, André F. A., additional
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- 2023
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3. SARS-CoV-2 lineage-specific disease symptoms and disease severity in São Caetano do Sul city, Brazil
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Sales, Flavia Cristina da Silva, primary, Prete, Carlos Augusto, additional, Abade, Leandro, additional, Buss, Lewis Fletcher, additional, Candido, Darlan da Silva, additional, Claro, Ingra Morales, additional, Moreira, Filipe Romero Rebello, additional, Manulli, Erika Regina, additional, Capuani, Ligia, additional, Maia, Camila Alves da Silva, additional, Oliveira, Beatriz Araujo, additional, Coletti, Thais, additional, Paiao, Heuder Gustavo Oliveira, additional, Costa, Silvia Figueiredo, additional, Correa, Maria Cassia Mendes, additional, Leal, Fabio Eudes, additional, Parag, Kris Varun, additional, Nascimento, Vítor Heloiz, additional, Faria, Nuno Rodrigues, additional, and Sabino, Ester Cerdeira, additional
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- 2023
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4. Epidemiological and genomic investigation of chikungunya virus in Rio de Janeiro state, Brazil, between 2015 and 2018
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Moreira, Filipe Romero Rebello, primary, Menezes, Mariane Talon de, additional, Salgado-Benvindo, Clarisse, additional, Whittaker, Charles, additional, Cox, Victoria, additional, Chandradeva, Nilani, additional, Paula, Hury Hellen Souza de, additional, Martins, André Frederico, additional, Chagas, Raphael Rangel das, additional, Brasil, Rodrigo Decembrino Vargas, additional, Cândido, Darlan da Silva, additional, Herlinger, Alice Laschuk, additional, Ribeiro, Marisa de Oliveira, additional, Arruda, Monica Barcellos, additional, Alvarez, Patricia, additional, Tôrres, Marcelo Calado de Paula, additional, Dorigatti, Ilaria, additional, Brady, Oliver, additional, Voloch, Carolina Moreira, additional, Tanuri, Amilcar, additional, Iani, Felipe, additional, Souza, William Marciel de, additional, Cardozo, Sergian Vianna, additional, Faria, Nuno Rodrigues, additional, and Aguiar, Renato Santana, additional
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- 2023
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5. Fecal Virome ofCoendou spinosus(Paraguaian Hairy Dwarf Porcupine)
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Miranda, Thamiris dos Santos, primary, de Matos, Isabelle Gomes, additional, D’arc, Mirela, additional, Moreira, Filipe Romero Rebello, additional, Schiffler, Francine Bittencourt, additional, Cosentino, Matheus Augusto Calvano, additional, Coimbra, Amanda, additional, de Oliveira, Thiago Henrique, additional, Mouta, Ricardo, additional, Medeiros, Gabriel, additional, Girardi, Déa Luiza, additional, Lima, Monique, additional, Wanderkoke, Victor, additional, Francisco, Talitha Mayumi, additional, Soffiati, Flávio Landim, additional, Ferreira, Suelen Sanches, additional, Ruiz-Miranda, Carlos Ramon, additional, Soares, Marcelo Alves, additional, and dos Santos, André Felipe Andrade, additional
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- 2023
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6. Phylogenomics reconciles molecular data with the rich fossil record on the origin of living turtles
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Selvatti, Alexandre Pedro, primary, Moreira, Filipe Romero Rebello, additional, Carvalho, Daniel Cardoso, additional, Prosdocimi, Francisco, additional, Russo, Claudia Augusta de Moraes, additional, and Junqueira, Ana Carolina Martins, additional
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- 2023
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7. The Omicron Lineages BA.1 and BA.2 (Betacoronavirus SARS-CoV-2) Have Repeatedly Entered Brazil through a Single Dispersal Hub
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Lamarca, Alessandra P., primary, Souza, Ueric José Borges de, additional, Moreira, Filipe Romero Rebello, additional, Almeida, Luiz G. P. de, additional, Menezes, Mariane Talon de, additional, Souza, Adrieli Barboza de, additional, Ferreira, Alessandro Clayton de Souza, additional, Gerber, Alexandra L., additional, Lima, Aline B. de, additional, Guimarães, Ana Paula de C., additional, Cavalcanti, Andréa Cony, additional, Silva, Aryel B. Paz e, additional, Lima, Bruna Israel, additional, Lobato, Cirley, additional, Silva, Cristiane Gomes Da, additional, Mendonça, Cristiane P. T. B., additional, Queiroz, Daniel Costa, additional, Zauli, Danielle Alves Gomes, additional, Menezes, Diego, additional, Possebon, Fábio Sossai, additional, Cardoso, Franciano Dias Pereira, additional, Malta, Frederico Scott Varella, additional, Braga-Paz, Isabela, additional, Silva, Joice do Prado, additional, Ferreira, Jorge Gomes Goulart, additional, Galvão, Jucimária Dantas, additional, Souza, Leandro Magalhães de, additional, Ferreira, Leonardo, additional, Possuelo, Lia Gonçalves, additional, Cavalcante, Liliane Tavares de Faria, additional, Alvim, Luige B., additional, Souza, Luiz Fellype Alves de, additional, Santos, Luiza C. G. de Araújo E, additional, Dias, Rillery Calixto, additional, Souza, Rutilene Barbosa, additional, Castro, Thaís Regina y, additional, Valim, Andréia Rosane de Moura, additional, Campos, Fabrício Souza, additional, Araujo, João Pessoa, additional, Trindade, Priscila de Arruda, additional, Aguiar, Renato S., additional, Michael Delai, Robson, additional, and Vasconcelos, Ana Tereza R de, additional
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- 2023
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8. Cyanovirin-N binds to select SARS-CoV-2 spike oligosaccharides outside of the receptor binding domain and blocks infection by SARS-CoV-2
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Muñoz-Basagoiti, Jordana, primary, Monteiro, Fábio Luís Lima, additional, Krumpe, Lauren R. H., additional, Armario-Najera, Victoria, additional, Shenoy, Shilpa R., additional, Perez-Zsolt, Daniel, additional, Westgarth, Harrison James, additional, Villorbina, Gemma, additional, Bomfim, Larissa Maciel, additional, Raïch-Regué, Dàlia, additional, Nogueras, Lara, additional, Henrich, Curtis J., additional, Gallemí, Marçal, additional, Moreira, Filipe Romero Rebello, additional, Torres, Pascual, additional, Wilson, Jennifer, additional, D’arc, Mirela, additional, Marfil, Silvia, additional, Herlinger, Alice Laschuk, additional, Pradenas, Edwards, additional, Higa, Luiza Mendonça, additional, Portero-Otin, Manuel, additional, Trinité, Benjamin, additional, Twyman, Richard M., additional, Capell, Teresa, additional, Tanuri, Amilcar, additional, Blanco, Julià, additional, Izquierdo-Useros, Nuria, additional, Rech, Elibio L., additional, Christou, Paul, additional, and O’Keefe, Barry R., additional
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- 2023
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9. Dynamics of Early Establishment of SARS-CoV-2 VOC Omicron Lineages in Minas Gerais, Brazil
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de Menezes, Mariane Talon, primary, Moreira, Filipe Romero Rebello, additional, Whittaker, Charles, additional, Santos, Franciele Martins, additional, Queiroz, Daniel Costa, additional, Geddes, Victor, additional, Fonseca, Paula Luize Camargos, additional, de Jesus, Jaqueline Góes, additional, Mendes-Oliveira, Franciane, additional, Reis-Souza, Valquíria, additional, Santos, Bibiana, additional, Zauli, Danielle Alves Gomes, additional, de Lima, Aline Brito, additional, de Brito Mendonça, Cristiane, additional, Alvim, Luige Biciati, additional, do Prado Silva, Joice, additional, Malta, Frederico Scott Varella, additional, de Souza Ferreira, Alessandro Clayton, additional, Faria, Nuno R., additional, Sabino, Ester Cerdeira, additional, and Aguiar, Renato Santana, additional
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- 2023
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10. Cyanovirin-N binds to select SARS-CoV-2 spike oligosaccharides outside of the receptor binding domain and blocks infection by SARS-CoV-2
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Muñoz-Basagoiti, Jordana, Monteiro, Fábio Luís Lima, Krumpe, Lauren R.H., Armario-Nájera, Victoria, Shenoy, Shilpa R., Perez-Zsolt, Daniel, Westgarth, Harrison James, Villorbina Noguera, Gemma, Bomfim, Larissa Maciel, Raïch-Regué, Dàlia, Nogueras Penabad, Lara, Henrich, Curtis J., Gallemí, Marçal, Moreira, Filipe Romero Rebello, Torres Cabestany, Pascual, Wilson, Jennifer, D’arc, Mirela, Marfil, Silvia, Herlinger, Alice Laschuk, Pradenas, Edwards, Higa, Luiza Mendonça, Portero Otín, Manuel, Trinité, Benjamin, Twyman, Richard M., Capell Capell, Teresa, Tanuri, Amilcar, Blanco, Julià, Izquierdo-Useros, Nuria, Rech, Elibio L., Christou, Paul, O’Keefec, Barry R., and Higa, Higa,Luiza Mendonça
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Multidisciplinary ,Cyanovirin N ,Antiviral ,Lectin ,Oligosacàrids - Abstract
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is an enveloped positive stranded RNA virus which has caused the recent deadly pandemic called COVID-19. The SARS-CoV-2 virion is coated with a heavily glycosylated Spike glycoprotein which is responsible for attachment and entry into target cells. One, as yet unexploited strategy for preventing SARS-CoV-2 infections, is the targeting of the glycans on Spike. Lectins are carbohydrate-binding proteins produced by plants, algae, and cyanobacteria. Some lectins can neutralize enveloped viruses displaying external glycoproteins, offering an alternative therapeutic approach for the prevention of infection with virulent β-coronaviruses, such as SARS-CoV-2. Here we show that the cyanobacterial lectin cyanovirin-N (CV-N) can selectively target SARS-CoV-2 Spike oligosaccharides and inhibit SARS-CoV-2 infection in vitro and in vivo. CV-N neutralizes Delta and Omicron variants in vitro better than earlier circulating viral variants. CV-N binds selectively to Spike with a Kd as low as 15 nM and a stoichiometry of 2 CV-N: 1 Spike but does not bind to the receptor binding domain (RBD). Further mapping of CV-N binding sites on Spike shows that select high-mannose oligosaccharides in the S1 domain of Spike are targeted by CV-N. CV-N also reduced viral loads in the nares and lungs in vivo to protect hamsters against a lethal viral challenge. In summary, we present an anti-coronavirus agent that works by an unexploited mechanism and prevents infection by a broad range of SARS-CoV-2 strains. Agricultural Biotechnology and Bioeconomy Unit (ABBU), Universitat de Lleida, Spain, EU Pharma-Factory grant agreement 77,4078 to P.C. Research in NI-U’s lab is supported by the Spanish Ministry of Science and Innovation (grant PID2020-117145RB-I00),EU HORIZON-HLTH-2021-CORONA-01 (grant 101046118) and by institutional funding of Grifols,Pharma Mar,HIPRA,Amassence,and Palobiofarma. E.L.R. is supported by Embrapa Genetic Resources and Biotechnology/National Institute of Science and Technology in Synthetic Biology, National Council for Scientific and Technological Development (465603/2014-9), Research Support Foundation of the Federal District (0193.001.262/2017), and Coordination for the Improvement of Higher Education Personnel. This research has been supported in part by the Intramural Research Program of the NIH, NCI, Center for Cancer Research and with federal funds from the NCI, NIH, under contract HHSN261200800001E. The content of this publication does not necessarily reflect the views or policies of the Department of Health and Human Services, nor does mention of trade names, commercial products, or organizations imply endorsement by the U.S.Government.All animal experiments were approved by
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- 2023
11. Monitoring the Establishment of VOC Gamma in Minas Gerais, Brazil: A Retrospective Epidemiological and Genomic Surveillance Study
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Alves, Hugo José, primary, de Araújo, João Locke Ferreira, additional, Fonseca, Paula Luize Camargos, additional, Moreira, Filipe Romero Rebello, additional, Bonfim, Diego Menezes, additional, Queiroz, Daniel Costa, additional, Miguita, Lucyene, additional, de Souza, Rafael Marques, additional, Geddes, Victor Emmanuel Viana, additional, Costa, Walyson Coelho, additional, Oliveira, Jaqueline Silva de, additional, Medeiros, Eva Lídia Arcoverde, additional, Souza, Carolina Senra Alves de, additional, Saliba, Juliana Wilke, additional, Menezes, André Luiz, additional, Oliveira, Eneida Santos de, additional, Adelino, Talita Emile Ribeiro, additional, Guimaraes, Natalia Rocha, additional, Ribeiro, Adriana Aparecida, additional, Moreira, Rennan Garcias, additional, Zauli, Danielle Alves Gomes, additional, Silva, Joice do Prado, additional, Malta, Frederico Scott Varella, additional, Ferreira, Alessandro Clayton de Souza, additional, Silva, Ana Valesca Fernandes Gilson, additional, Alfenas-Zerbini, Poliane, additional, Souza, Flavia Oliveira de, additional, Sabino, Adriano de Paula, additional, Xavier, Laura do Amaral, additional, Carobin, Natália Virtude, additional, Carvalho, Alex Fiorini de, additional, Lourenço, Karine Lima, additional, Teixeira, Santuza Maria Ribeiro, additional, Fernandes, Ana Paula Salles Moura, additional, Fonseca, Flavio Guimarães da, additional, Abrahão, Jônatas Santos, additional, Iani, Felipe Campos de Melo, additional, Rodrigues, Rodrigo Araújo Lima, additional, Souza, Renan Pedra de, additional, and Aguiar, Renato Santana, additional
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- 2022
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12. Metagenomic analysis reveals novel dietary-related viruses in the gut virome of marmosets hybrids (Callithrix jacchus x Callithrix penicillata), Brazil
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Miranda, Thamiris dos Santos, primary, Schiffler, Francine Bittencourt, additional, D’arc, Mirela, additional, Moreira, Filipe Romero Rebello, additional, Cosentino, Matheus Augusto Calvano, additional, Coimbra, Amanda, additional, Mouta, Ricardo, additional, Medeiros, Gabriel, additional, Girardi, Déa Luiza, additional, Wanderkoke, Victor, additional, Soares, Caique Ferreira Amaral, additional, Francisco, Talitha Mayumi, additional, Henry, Malinda Dawn, additional, Afonso, Bianca Cardozo, additional, Soffiati, Flávio Landim, additional, Ferreira, Suelen Sanches, additional, Ruiz-Miranda, Carlos Ramon, additional, Soares, Marcelo Alves, additional, and dos Santos, André Felipe Andrade, additional
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- 2022
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13. Discovery of two novel Torque Teno viruses in Callithrix penicillata provides insights on Anelloviridae diversification dynamics
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Cosentino, Matheus Augusto Calvano, primary, D’arc, Mirela, additional, Moreira, Filipe Romero Rebello, additional, Cavalcante, Liliane Tavares de Faria, additional, Mouta, Ricardo, additional, Coimbra, Amanda, additional, Schiffler, Francine Bittencourt, additional, Miranda, Thamiris dos Santos, additional, Medeiros, Gabriel, additional, Dias, Cecilia A., additional, Souza, Antonizete R., additional, Tavares, Maria Clotilde Henriques, additional, Tanuri, Amilcar, additional, Soares, Marcelo Alves, additional, and Santos, André Felipe Andrade dos, additional
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- 2022
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14. A SARS-CoV-2 Negative Antigen Rapid Diagnostic in RT-qPCR Positive Samples Correlates With a Low Likelihood of Infectious Viruses in the Nasopharynx
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Corrêa, Isadora Alonso, primary, Faffe, Débora Souza, additional, Galliez, Rafael Mello, additional, Gonçalves, Cássia Cristina Alves, additional, Maia, Richard Araújo, additional, da Silva, Gustavo Peixoto, additional, Moreira, Filipe Romero Rebello, additional, Mariani, Diana, additional, Campos, Mariana Freire, additional, Leitão, Isabela de Carvalho, additional, de Souza, Marcos Romário, additional, Cunha, Marcela Sabino, additional, Nascimento, Érica Ramos dos Santos, additional, Ribeiro, Liane de Jesus, additional, da Cruz, Thais Felix Cordeiro, additional, Policarpo, Cintia, additional, Gonzales, Luis, additional, Rodgers, Mary A., additional, Berg, Michael, additional, Vijesurier, Roy, additional, Cloherty, Gavin A., additional, Hackett, John, additional, Ferreira, Orlando da Costa, additional, Castiñeiras, Terezinha Marta Pereira Pinto, additional, Tanuri, Amilcar, additional, and da Costa, Luciana Jesus, additional
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- 2022
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15. Biosafety in Dental Health Care During the COVID-19 Pandemic: A Longitudinal Study
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Miguita, Lucyene, primary, Martins-Chaves, Roberta Rayra, additional, Geddes, Victor Emmanuel Viana, additional, Mendes, Suellen da Rocha, additional, Costa, Sara Ferreira dos Santos, additional, Fonseca, Paula Luize Camargos, additional, Menezes, Diego, additional, Souza, Rafael Marques de, additional, Queiroz, Daniel Costa, additional, Alves, Hugo José, additional, Freitas, Raphaela Alvarenga Braga de, additional, Cruz, Aline Fernanda, additional, Moreira, Rennan Garcias, additional, Moreira, Filipe Romero Rebello, additional, Bemquerer, Larissa Marques, additional, Aguilar, Diego Rodrigues de, additional, Souza e Silva, Maria Elisa de, additional, Sampaio, Aline Araújo, additional, Jardilino, Francisca Daniele Moreira, additional, Souza, Leandro Napier de, additional, Silva, Tarcilia Aparecida da, additional, Gomes, Carolina Cavaliéri, additional, de Abreu, Mauro Henrique Nogueira Guimarães, additional, Aguiar, Renato Santana de, additional, Souza, Renan Pedra de, additional, and Gomez, Ricardo Santiago, additional
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- 2022
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16. Identification and characterisation of SARS-CoV-2 and Human alphaherpesvirus 1 from a productive coinfection in a fatal COVID-19 case
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Herlinger, Alice Laschuk, Monteiro, Fábio Luís Lima, D’arc, Mirela, Moreira, Filipe Romero Rebello, Westgarth, Harrison James, Galliez, Rafael Mello, Mariani, Diana, da Costa, Luciana Jesus, de Almeida, Luiz Gonzaga Paula, Voloch, Carolina Moreira, Melo, Adriana Suely de Oliveira, Aguiar, Renato Santana de, dos Santos, André Felipe Andrade, Castiñeiras, Terezinha Marta Pereira Pinto, de Vasconcelos, Ana Tereza Ribeiro, João Filho, Esaú Custódio, Escosteguy, Claudia Caminha, Ferreira Junior, Orlando da Costa, Tanuri, Amilcar, and Higa, Luiza Mendonça
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SARS-CoV-2 ,viruses ,coronavirus ,COVID-19 ,HSV-1 ,coinfection - Abstract
BACKGROUND During routine Coronavirus disease 2019 (COVID-19) diagnosis, an unusually high viral load was detected by reverse transcription real-time polymerase chain reaction (RT-qPCR) in a nasopharyngeal swab sample collected from a patient with respiratory and neurological symptoms who rapidly succumbed to the disease. Therefore we sought to characterise the infection. OBJECTIVES We aimed to determine and characterise the etiological agent responsible for the poor outcome. METHODS Classical virological methods, such as plaque assay and plaque reduction neutralisation test combined with amplicon-based sequencing, as well as a viral metagenomic approach, were performed to characterise the etiological agents of the infection. FINDINGS Plaque assay revealed two distinct plaque phenotypes, suggesting either the presence of two severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) strains or a productive coinfection of two different species of virus. Amplicon-based sequencing did not support the presence of any SARS-CoV-2 genetic variants that would explain the high viral load and suggested the presence of a single SARS-CoV-2 strain. Nonetheless, the viral metagenomic analysis revealed that Coronaviridae and Herpesviridae were the predominant virus families within the sample. This finding was confirmed by a plaque reduction neutralisation test and PCR. MAIN CONCLUSIONS We characterised a productive coinfection of SARS-CoV-2 and Herpes simplex virus 1 (HSV-1) in a patient with severe symptoms that succumbed to the disease. Although we cannot establish the causal relationship between the coinfection and the severity of the clinical case, this work serves as a warning for future studies focused on the interplay between SARS-CoV-2 and HSV-1 coinfection and COVID-19 severity.
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- 2022
17. Seroprevalence, Prevalence, and Genomic Surveillance: Monitoring the Initial Phases of the SARS-CoV-2 Pandemic in Betim, Brazil
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Silva, Ana Valesca Fernandes Gilson, primary, Menezes, Diego, additional, Moreira, Filipe Romero Rebello, additional, Torres, Octávio Alcântara, additional, Fonseca, Paula Luize Camargos, additional, Moreira, Rennan Garcias, additional, Alves, Hugo José, additional, Alves, Vivian Ribeiro, additional, Amaral, Tânia Maria de Resende, additional, Coelho, Adriano Neves, additional, Saraiva Duarte, Júlia Maria, additional, da Rocha, Augusto Viana, additional, de Almeida, Luiz Gonzaga Paula, additional, de Araújo, João Locke Ferreira, additional, de Oliveira, Hilton Soares, additional, de Oliveira, Nova Jersey Cláudio, additional, Zolini, Camila, additional, de Sousa, Jôsy Hubner, additional, de Souza, Elizângela Gonçalves, additional, de Souza, Rafael Marques, additional, Ferreira, Luciana de Lima, additional, Lehmkuhl Gerber, Alexandra, additional, Guimarães, Ana Paula de Campos, additional, Maia, Paulo Henrique Silva, additional, Marim, Fernanda Martins, additional, Miguita, Lucyene, additional, Monteiro, Cristiane Campos, additional, Neto, Tuffi Saliba, additional, Pugêdo, Fabrícia Soares Freire, additional, Queiroz, Daniel Costa, additional, Queiroz, Damares Nigia Alborguetti Cuzzuol, additional, Resende-Moreira, Luciana Cunha, additional, Santos, Franciele Martins, additional, Souza, Erika Fernanda Carlos, additional, Voloch, Carolina Moreira, additional, Vasconcelos, Ana Tereza, additional, de Aguiar, Renato Santana, additional, and de Souza, Renan Pedra, additional
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- 2022
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18. Shotgun metagenomic sequencing of the first case of monkeypox virus in Brazil, 2022
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Claro, Ingra Morales, primary, Romano, Camila Malta, additional, Candido, Darlan da Silva, additional, Lima, Evelyn Lepka de, additional, Lindoso, José Angelo Lauletta, additional, Ramundo, Mariana Severo, additional, Moreira, Filipe Romero Rebello, additional, Barra, Luiz Alberto Costa, additional, Borges, Luciana Marques Sansão, additional, Medeiros, Lucas Alberto, additional, Tomishige, Marcia Y. S., additional, Moutinho, Tomas, additional, Silva, Anderson José Dias da, additional, Rodrigues, Camila Cristina Martini, additional, Azevedo, Luiz Cesar Fernandes de, additional, Villas-Boas, Lucy Santos, additional, Silva, Camila Alves Maia da, additional, Coletti, Thaís Moura, additional, Manuli, Erika R., additional, O’Toole, Aine, additional, Quick, Joshua, additional, Loman, Nicholas, additional, Rambaut, Andrew, additional, Faria, Nuno R., additional, Figueiredo-Mello, Claudia, additional, and Sabino, Ester Cerdeira, additional
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- 2022
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19. Prolonged SARS-CoV-2 Positivity in Immunocompetent Patients: Virus Isolation, Genomic Integrity, and Transmission Risk
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Leitão, Isabela de Carvalho, primary, Calil, Pedro Telles, additional, Galliez, Rafael Mello, additional, Moreira, Filipe Romero Rebello, additional, Mariani, Diana, additional, Castiñeiras, Anna Carla Pinto, additional, da Silva, Gustavo Peixoto Duarte, additional, Maia, Richard Araújo, additional, Corrêa, Isadora Alonso, additional, Monteiro, Fábio Luís Lima, additional, de Souza, Marcos Romário Matos, additional, Gonçalves, Cássia Cristina Alves, additional, Higa, Luiza Mendonça, additional, de Jesus Ribeiro, Liane, additional, Fonseca, Vinicius Wakoff Pereira, additional, Bastos, Victoria Cortes, additional, Voloch, Carolina Moreira, additional, Faffe, Débora Souza, additional, da Costa Ferreira, Orlando, additional, Tanuri, Amilcar, additional, Castiñeiras, Terezinha Marta Pereira Pinto, additional, and da Costa, Luciana Jesus, additional
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- 2021
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20. Seroprevalence, prevalence, and genomic surveillance: monitoring the initial phases of the SARS-CoV-2 pandemic in Betim, Brazil
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Gilson Silva, Ana Valesca Fernandes, primary, Menezes, Diego, additional, Moreira, Filipe Romero Rebello, additional, Torres, Octavio Alcantara, additional, Fonseca, Paula Luize Camargos, additional, Moreira, Rennan Garcias, additional, Alves, Hugo Jose, additional, Alves, Vivian Ribeiro, additional, Amaral, Tania Maria de Resende, additional, Coelho, Adriano Neves, additional, Saraiva-Duarte, Julia Maria, additional, da Rocha, Augusto Viana, additional, de Almeida, Luiz Gonzaga Paula, additional, de Araujo, Joao Locke Ferreira, additional, de Oliveira, Hilton Soares, additional, de Oliveira, Nova Jersey Claudio, additional, de Sa, Camila Zolini, additional, de Souza, Josy Hubner, additional, de Souza, Elizangela Goncalves, additional, de Souza, Rafael Marques, additional, Ferreira, Luciana de Lima, additional, Gerber, Alexandra Lehmkuhl, additional, Guimaraes, Ana Paula de Campos, additional, Maia, Paulo Henrique Silva, additional, Marim, Fernanda Martins, additional, Miguita, Lucyene, additional, Monteiro, Cristiane Campos, additional, Saliba Neto, Tuffi, additional, Pugedo, Fabricia Soares Freire, additional, Queiroz, Daniel Costa, additional, Cuzzuol Queiroz, Damares Nigia Alborguetti, additional, Resende-Moreira, Luciana Cunha, additional, Santos, Franciele Martins, additional, Souza, Erika Fernanda Carlos, additional, Voloch, Carolina Moreira, additional, Vasconcelos, Ana Tereza, additional, Aguiar, Renato Santana de, additional, and Souza, Renan Pedra de, additional
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- 2021
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21. Epidemiological dynamics of SARS-CoV-2 VOC Gamma in Rio de Janeiro, Brazil
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Moreira, Filipe Romero Rebello, primary, D’arc, Mirela, additional, Mariani, Diana, additional, Herlinger, Alice Laschuk, additional, Schiffler, Francine Bittencourt, additional, Rossi, Átila Duque, additional, Leitão, Isabela de Carvalho, additional, Miranda, Thamiris dos Santos, additional, Cosentino, Matheus Augusto Calvano, additional, Tôrres, Marcelo Calado de Paula, additional, da Costa, Raíssa Mirella dos Santos Cunha, additional, Gonçalves, Cássia Cristina Alves, additional, Faffe, Débora Souza, additional, Galliez, Rafael Mello, additional, Junior, Orlando da Costa Ferreira, additional, Aguiar, Renato Santana, additional, Dos Santos, André Felipe Andrade, additional, Voloch, Carolina Moreira, additional, Castiñeiras, Terezinha Marta Pereira Pinto, additional, and Tanuri, Amilcar, additional
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- 2021
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22. Common Dysregulation of Innate Immunity Pathways in Human Primary Astrocytes Infected With Chikungunya, Mayaro, Oropouche, and Zika Viruses
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Geddes, Victor Emmanuel Viana, primary, Brustolini, Otávio José Bernardes, additional, Cavalcante, Liliane Tavares de Faria, additional, Moreira, Filipe Romero Rebello, additional, de Castro, Fernando Luz, additional, Guimarães, Ana Paula de Campos, additional, Gerber, Alexandra Lehmkuhl, additional, Figueiredo, Camila Menezes, additional, Diniz, Luan Pereira, additional, Neto, Eurico de Arruda, additional, Tanuri, Amilcar, additional, Souza, Renan Pedra, additional, Assunção-Miranda, Iranaia, additional, Alves-Leon, Soniza Vieira, additional, Romão, Luciana Ferreira, additional, de Souza, Jorge Paes Barreto Marcondes, additional, de Vasconcelos, Ana Tereza Ribeiro, additional, and de Aguiar, Renato Santana, additional
- Published
- 2021
- Full Text
- View/download PDF
23. Biosafety in Dental Health Care During Covid-19 Pandemic: A Longitudinal Study
- Author
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Miguita, Lucyene, primary, Martins-Chaves, Roberta Rayra, additional, Geddes, Victor Emmanuel Viana, additional, Mendes, Suellen da Rocha, additional, Costa, Sara Ferreira dos Santos, additional, Menezes, Diego, additional, Fonseca, Paula Luize Camargos, additional, Souza, Rafael Marques de, additional, Queiroz, Daniel Costa, additional, Alves, Hugo José, additional, Freitas, Raphaela Alvarenga Braga de, additional, Cruz, Aline Fernanda, additional, Moreira, Rennan Garcias, additional, Moreira, Filipe Romero Rebello, additional, Bemquerer, Larissa Marques, additional, de Aguilar, Diego Rodrigues, additional, Souza e Silva, Maria Elisa de, additional, Sampaio, Aline Araujo, additional, Silami, Francisca Daniele Jardilino, additional, de Souza, Leandro Napier, additional, Silva, Tarcilia Aparecida da, additional, Gomes, Carolina Cavaliéri, additional, de Abreu, Mauro Henrique Nogueira Guima, additional, Aguiar, Renato Santana de, additional, de Souza, Renan Pedra, additional, and Gomez, Ricardo Santiago, additional
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- 2021
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24. A novel Betacoronavirus characterised in collared peccaries from the Rio de Janeiro Zoo (Brazil) killed by unknown disease
- Author
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D’arc, Mirela, primary, Cosentino, Matheus Calvano, additional, Moreira, Filipe Romero Rebello, additional, Cavalcante, Liliane Tavares Faria, additional, Augusto, Anderson Mendes, additional, Trocolli, Fernando, additional, Ubiali, Daniel Guimarães, additional, Verona, Carlos Eduardo, additional, Soares, Marcelo Alves, additional, and Santos, André Felipe, additional
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- 2020
- Full Text
- View/download PDF
25. Oropouche virus genomic surveillance in Brazil.
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Moreira FRR, Dutra JVR, de Carvalho AHB, Reis CR, Rios JSH, Ribeiro MO, Arruda MB, Alvarez P, Souza RP, Voloch C, Zauli DAG, and Aguiar RS
- Abstract
Competing Interests: We declare no competing interests. All new Oropouche virus genome sequences were deposited on NCBI GenBank under accessions PQ066768 to PQ066785. We acknowledge all authors who submitted Oropouche virus genome sequences to National Center for Biotechnology Information GenBank, making this and other genomic epidemiology efforts possible. A complete list of data contributors is available in the appendix. Editorial note: The Lancet Group takes a neutral position with respect to territorial claims in published maps and institutional affiliations.
- Published
- 2024
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26. Identification and characterisation of SARS-CoV-2 and Human alphaherpesvirus 1 from a productive coinfection in a fatal COVID-19 case.
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Herlinger AL, Monteiro FLL, D'arc M, Moreira FRR, Westgarth HJ, Galliez RM, Mariani D, da Costa LJ, de Almeida LGP, Voloch CM, Melo ASO, Aguiar RS, Dos Santos AFA, Castiñeiras TMPP, de Vasconcelos ATR, João Filho EC, Escosteguy CC, Ferreira Junior ODC, Tanuri A, and Higa LM
- Subjects
- Humans, Real-Time Polymerase Chain Reaction, SARS-CoV-2, COVID-19, Coinfection, Herpesvirus 1, Human genetics
- Abstract
Background: During routine Coronavirus disease 2019 (COVID-19) diagnosis, an unusually high viral load was detected by reverse transcription real-time polymerase chain reaction (RT-qPCR) in a nasopharyngeal swab sample collected from a patient with respiratory and neurological symptoms who rapidly succumbed to the disease. Therefore we sought to characterise the infection., Objectives: We aimed to determine and characterise the etiological agent responsible for the poor outcome., Methods: Classical virological methods, such as plaque assay and plaque reduction neutralisation test combined with amplicon-based sequencing, as well as a viral metagenomic approach, were performed to characterise the etiological agents of the infection., Findings: Plaque assay revealed two distinct plaque phenotypes, suggesting either the presence of two severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) strains or a productive coinfection of two different species of virus. Amplicon-based sequencing did not support the presence of any SARS-CoV-2 genetic variants that would explain the high viral load and suggested the presence of a single SARS-CoV-2 strain. Nonetheless, the viral metagenomic analysis revealed that Coronaviridae and Herpesviridae were the predominant virus families within the sample. This finding was confirmed by a plaque reduction neutralisation test and PCR., Main Conclusions: We characterised a productive coinfection of SARS-CoV-2 and Herpes simplex virus 1 (HSV-1) in a patient with severe symptoms that succumbed to the disease. Although we cannot establish the causal relationship between the coinfection and the severity of the clinical case, this work serves as a warning for future studies focused on the interplay between SARS-CoV-2 and HSV-1 coinfection and COVID-19 severity.
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- 2022
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27. A novel Betacoronavirus characterised in collared peccaries from the Rio de Janeiro Zoo (Brazil) killed by unknown disease.
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D'arc M, Cosentino MC, Moreira FRR, Cavalcante LTF, Augusto AM, Trocolli F, Ubiali DG, Verona CE, Soares MA, and Santos AF
- Subjects
- Animals, Betacoronavirus genetics, Brazil, Coronavirus Infections diagnosis, Coronavirus Infections mortality, Artiodactyla virology, Betacoronavirus isolation & purification
- Abstract
In an enclosure with nine collared peccaries (Pecari tajacu) from the Rio de Janeiro city Zoo, Brazil, one specimen was found dead and two others developed prostration, apathy and dehydration, resulting on its death. Necropsy of two animals pointed to pulmonary and renal damage. Histological examination revealed vasculitis in spleen from both P. tajacu, suggesting a systemic viral infection. Lungs from one specimen showed fibrinoid vasculitis, alveolar damage with hyaline membrane, and interstitial lymphocytes infiltration. Virome analysis in anal wash samples from the latter two animals revealed a new type of Betacoronavirus, lineage A, provisionally named Ptajacu-CoV.
- Published
- 2020
- Full Text
- View/download PDF
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