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Cardiac catheterization remains the gold standard for the diagnosis and management of pediatric pulmonary hypertension (PH). There is lack of consensus regarding optimal anesthetic and airway regimen. This retrospective study describes the anesthetic/airway experience of our single center cohort of pediatric PH patients undergoing catheterization, in which obtaining hemodynamic data during spontaneous breathing is preferential. A total of 448 catheterizations were performed in 232 patients. Of the 379 cases that began with a natural airway, 274 (72%) completed the procedure without an invasive airway, 90 (24%) received a planned invasive airway, and 15 (4%) required an unplanned invasive airway. Median age was 3.4 years (interquartile range [IQR] 0.7-9.7); the majority were either Nice Classification Group 1 (48%) or Group 3 (42%). Vasoactive medications and cardiopulmonary resuscitation were required in 14 (3.7%) and eight (2.1%) cases, respectively; there was one death. Characteristics associated with use of an invasive airway included age

Enlargement of the endolymphatic sac, duct, and vestibular aqueduct (EVA) is the most common inner ear malformation identified in patients with sensorineural hearing loss. EVA is associated with pathogenic variants in SLC26A4. However, in European-Caucasian populations, about 50% of patients with EVA carry no pathogenic alleles of SLC26A4. We tested for the presence of variants in CHD7, a gene known to be associated with CHARGE syndrome, Kallmann syndrome, and hypogonadotropic hypogonadism, in a cohort of 34 families with EVA subjects without pathogenic alleles of SLC26A4. In two families, NM_017780.4: c.3553A > G [p.(Met1185Val)] and c.5390G > C [p.(Gly1797Ala)] were detected as monoallelic CHD7 variants in patients with EVA. At least one subject from each family had additional signs or potential signs of CHARGE syndrome but did not meet diagnostic criteria for CHARGE. In silico modeling of these two missense substitutions predicted detrimental effects upon CHD7 protein structure. Consistent with a role of CHD7 in this tissue, Chd7 transcript and protein were detected in all epithelial cells of the endolymphatic duct and sac of the developing mouse inner ear. These results suggest that some CHD7 variants can cause nonsyndromic hearing loss and EVA. CHD7 should be included in DNA sequence analyses to detect pathogenic variants in EVA patients. Chd7 expression and mutant phenotype data in mice suggest that CHD7 contributes to the formation or function of the endolymphatic sac and duct.

Los cuadros de las Filiales Universitarias Municipales y de los Centros Universitarios Municipa-les, presentan limitaciones en su visión sobre equidad y género; es insuficiente la incorporacióna su accionar como directivos, de nuevos conceptos y modelos que distinguen las relacionescontemporáneas entre ciencia, tecnología y sociedad; es limitado el tratamiento de la equidady género desde la perspectiva de Ciencia Tecnología y Sociedad en su superación profesional.La situación descrita permite formular el siguiente problema científico: ¿Cómo contribuir ala superación de cuadros en equidad y género desde la perspectiva de Ciencia Tecnología ySociedad? El objetivo fue proponer un sistema de acciones para la superación profesionalde los cuadros de las Filiales Universitarias Municipales y de los Centros UniversitariosMunicipales de la Universidad de Ciego de Ávila en equidad y género desde la perspectivaCiencia Tecnología y Sociedad. Se utilizaron como técnicas: la encuesta y la observacióncientífica para caracterizar el estado de los conocimientos y prácticas sobre equidad y génerodesde la perspectiva Ciencia Tecnología y Sociedad y de la superación profesional de los cuadros. Se diseñó un sistema de acciones de superación profesional cuya pertinencia fuecorroborada mediante taller de socialización con especialistas.

Introduction: Benzodiazepines are frequently prescribed and misused therefore urine drug screening (UDS) is performed in many patient populations. Most current benzodiazepine immunoassays have poor sensitivity, particularly for detecting the metabolites of newer benzodiazepines such as lorazepam in urine. Objectives: We aimed to verify the clinical performance of the new qualitative Roche Benzodiazepines II (BNZ2) immunoassay, as well as compare its performance to the Roche Benzodiazepines Plus (BENZ) assay in two patient populations: UDS in the emergency department (ED) and compliance monitoring. Methods: An initial verification study was performed, selecting for samples containing clonazepam and lorazepam metabolites. Performance of the BNZ2 and BENZ assays was compared to liquid chromatography-tandem mass spectrometry (LC-MS/MS) as the reference method. Sensitivity, specificity, false positive rate (FPR) and false negative rate (FNR) were determined. Results: We verified the performance claims in the initial verification and demonstrated similar precision, with coefficient of variations (CVs) of 12.8% and 7.7% for negative and positive controls, respectively. Furthermore, we observed higher clinical sensitivity and lower FNR with the BNZ2 assay in both the ED and compliance monitoring populations due to improved cross-reactivity for lorazepam and clonazepam metabolites. Despite these improvements, the BNZ2 assay was unable to detect 27% of specimens positive by LC-MS/MS, including specimens from patients using benzodiazepines without prescription. Discussion: Due to its improved performance and rapid turnaround time, the BNZ2 assay should be implemented for UDS in the ED. However, the assay should not replace LC-MS/MS testing for compliance monitoring, as unsuspected benzodiazepine use may go undetected.

Introduction: Granular Cell Tumors (GCTs) are rare soft tissue neoplasms originating from Schwann cells, often benign but mimicking breast carcinoma clinically and radiologically. Case presentation: A 17-year-old female with a second-degree family history of breast cancer presented with a painful left breast mass (∼3 cm) persisting for three years. Initial evaluation with fine needle aspiration (FNA) suggested a benign lipoma, but imaging reported BIRADS IV mass. Mammography revealed an ovoid mass with irregular margins, Sono-mammogram reported heterogeneous slightly lobulated mass with excentric sonolucent of 3 x 2.4 × 1.8 cm, no increased vascularity on sono-doppler and core needle biopsy confirmed a GCT, positive for S-100 and CD68. The patient was taken to the operating room for surgical excision. A 4 cm curvilinear incision was made over the left breast mass, just lateral to the nipple at the 3 o'clock position. En-bloc excision of the mass was carried out with 1 cm margins. The specimen was removed and sent for frozen section analysis that confirmed the cytological diagnosis of a granular cell tumor with clear margins. The excised mass was sent for permanent section to pathology. Final histopathology confirmed a benign GCT with free margins. Due to the infiltrative nature of the tumor, a second excision in similar fashion was required to obtain wider margins, which was uneventful. Clear margins were pursued due to the tumor's infiltrative nature and patient's family history of breast cancer, despite the low risk of recurrence with positive margins. The patient remains clinically disease-free at three-year follow-up. Conclusion: Granular cell tumors of the breast, though benign, are often mistaken for carcinoma due to their clinical similarity. Complete excision with clear margins, which may require re-excision due to their infiltrative nature, is crucial to prevent recurrence.

IntroductionAccording to the latest Cancer Statistics, colorectal, lung, and melanoma are three of the most common cancers that affect both males and females. While males have consistently had a higher incidence and mortality rate in all three types of cancers, females have been shown to have better outcomes. Sex discrepancies in cancer research can impact the efficacy and effectiveness of novel drugs and diagnostic tools. Study results may not accurately represent how the treatment or diagnostic tool performs in the underrepresented sex. To comprehensively assess sex representation in top non-sex-specific cancer research, this systematic review aims to identify if there is equal representation of males and females in colorectal, lung, and melanoma cancer research.MethodsWe explored retrospective and prospective clinical studies published in Pubmed from 2014 to 2023 to identify possible sex discrepancies in colorectal, lung, and melanoma cancer. MeSH terms were employed to retrieve relevant studies for each cancer type (colorectal, lung, melanoma). MeSH terms used include “lung cancer”, “melanoma”, and “colorectal cancer”, in combination with “trials”, “retrospective”, and “prospective”. Extracted data included study characteristics (author, year of publication), study design (prospective or retrospective), sample size, and the number of male and female participants.ResultsThe complete study population consisted of 515,003 patients, of which 275,231 (53%) were males and 237,488 (46%) were females. Specifically, retrospective studies included a total of 302,974 patients with 163,473 (54%) of them identifying as male and 139,072 (46%) patients identifying as female. While prospective studies included a total of 212,029 patients with 111,758 (53%) of these being male and 98,416 (46%) being female. Overall, male representation in the studies included in this systematic review was higher than female representation.DiscussionDisparities in representation were identified in colorectal cancer, lung cancer, and melanoma cancer studies underscoring the need for equitable inclusion of both sexes in cancer research to advance precision medicine and improve patient outcomes. Further exploration of the impact of sex, race, and socioeconomic status on study representation is warranted.

Introduction: Angiolipomatosis is a rare benign condition involving subcutaneous fat and blood vessels, particularly uncommon in pediatric patients. Case presentation: An 11-year-old male presented with multiple firm, non-tender masses in the right gluteal and perianal regions, the largest measuring 8 cm for approximately 8 months duration. The patient underwent staged surgical excisions under general anesthesia due to extensive disease burden. In the first stage, perianal and medial gluteal masses were excised. Lipomatous masses were carefully dissected from the external anal sphincter to the posterior superior iliac spine (PSIS) with preservation of the external anal sphincter. The procedure was well tolerated, but the patient developed a postoperative wound infection, requiring intravenous antibiotics, debridement, and the creation of a loop colostomy to control wound contamination. Six weeks later, a second-stage excision removed the remaining gluteal masses, including a palpable mass measuring 8 x 4 × 2.5 cm. Hemostasis was achieved, and a Jackson-Pratt drain was placed to manage post-op wound fluid accumulation. The patient recovered well after both surgeries and at the 3-month follow-up, there were no complications. Pathological analysis confirmed angiolipomatosis in the gluteal region and diffuse lipomatosis in the perianal region. No recurrence was observed over a 3-year follow-up period. Conclusion: Angiolipomatosis should be considered as a differential diagnosis for pediatric soft tissue masses in uncommon locations like the gluteal and perianal regions. Atypical presentations can be successfully managed with careful surgical planning helping to avoid unnecessary radical procedures. A staged approach is recommended when encountering diffuse disease, as in this case, and consideration should be given to diverting ostomy if wound contamination is a concern.

Amid public concern surrounding the proprietary and exploitative use of personal data by corporations and public institutions, and its consequences from a sociotechnical perspective, narratives around digital commons have recently emerged, framing potential alternatives. This paper presents the co-creation of the Digital Democracy and Data Commons Manifesto through a collaborative writing sprint, drawing on principles of openness, diversity, and inclusivity. The manifesto articulates a technopolitical vision for data governance that prioritizes community control over data. We analyze the manifesto's evolution throughout the process, demonstrating its capacity to address contemporary concerns such as data extractivism and algorithmic governance. Our approach is based on participatory design methods, more concretely on a collaborative writing sprint, to co-create a manifesto on alternatives to current datafication, digital inequalities, and lack of citizen control over personal data. On the one hand, we describe the process of implementing a sprint approach for collaboratively writing a topic-specific manifesto, in the context of the broader EU project DECODE (Decentralised Citizen Owned Data Ecosystems). On the other hand, we present and analyse the main results from the content structure of the manifesto over its initial and final versions, which moved progressively as a cohesive text away from a scholarly and policy-oriented tone.

Abstract We investigated the corrosion properties and transpassive behavior of CrMnFeCoNi and CrCoNi multi‐principal element alloys (MPEAs) in a 0.1 M NaCl electrolyte at pH 12. By using SECM‐based tip substrate voltammetry (TSV) in combination with the chemical analysis of the electrolyte, we were able to differentiate between anodic metal dissolution and oxygen evolution in the transpassive range. Our investigations have shown that CrCoNi has a significantly higher corrosion resistance compared to CrMnFeCoNi. In the studied alkaline environment, a transpassive oxide film is formed on the surface of CrCoNi during secondary passivation. This transpassive oxide film appears to play a significant role in oxygen evolution, as the increase in TSV currents at the microelectrode coincides with the corresponding current density plateau of the voltametric current trace. The formation of the transpassive oxide film was not observed in previous studies conducted in acidic environments. Moreover, the alkaline electrolyte induced a positive hysteresis and mild pitting corrosion, in addition to intergranular corrosion, which was the sole corrosion process observed at acidic pH levels. These findings enhance the understanding of the processes governing the transpassivity of CrMnFeCoNi and CrCoNi MPEAs in alkaline environments and have potential implications for the development of application‐tailored corrosion‐resistant MPEAs.