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4 results on '"Moreno, Thalia Bracamonte"'

1. Allelic polymorphism controls autoreactivity and vaccine elicitation of human broadly neutralizing antibodies against influenza virus

Author

Sangesland, Maya, primary, Torrents de la Peña, Alba, additional, Boyoglu-Barnum, Seyhan, additional, Ronsard, Larance, additional, Mohamed, Faez Amokrane Nait, additional, Moreno, Thalia Bracamonte, additional, Barnes, Ralston M., additional, Rohrer, Daniel, additional, Lonberg, Nils, additional, Ghebremichael, Musie, additional, Kanekiyo, Masaru, additional, Ward, Andrew, additional, and Lingwood, Daniel, additional

Published
2022
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2. Naive human B cells engage the receptor binding domain of SARS-CoV-2, variants of concern, and related sarbecoviruses

Author

Feldman, Jared, primary, Bals, Julia, additional, Altomare, Clara G., additional, St. Denis, Kerri, additional, Lam, Evan C., additional, Hauser, Blake M., additional, Ronsard, Larance, additional, Sangesland, Maya, additional, Moreno, Thalia Bracamonte, additional, Okonkwo, Vintus, additional, Hartojo, Nathania, additional, Balazs, Alejandro B., additional, Bajic, Goran, additional, Lingwood, Daniel, additional, and Schmidt, Aaron G., additional

Published
2021
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3. Spontaneous Glycan Reattachment Following N-Glycanase Treatment of Influenza and HIV Vaccine Antigens

Author

Keating, Celina L., primary, Kuhn, Eric, additional, Bals, Julia, additional, Cocco, Alexandra R., additional, Yousif, Ashraf S., additional, Matysiak, Colette, additional, Sangesland, Maya, additional, Ronsard, Larance, additional, Smoot, Matthew, additional, Moreno, Thalia Bracamonte, additional, Okonkwo, Vintus, additional, Setliff, Ian, additional, Georgiev, Ivelin, additional, Balazs, Alejandro B., additional, Carr, Steven A., additional, and Lingwood, Daniel, additional

Published
2020
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4. Naive human B cells engage the receptor binding domain of SARS-CoV-2, variants of concern, and related sarbecoviruses.

Author

Feldman J, Bals J, Altomare CG, St Denis K, Lam EC, Hauser BM, Ronsard L, Sangesland M, Moreno TB, Okonkwo V, Hartojo N, Balazs AB, Bajic G, Lingwood D, and Schmidt AG

Abstract

Exposure to a pathogen elicits an adaptive immune response aimed to control and eradicate. Interrogating the abundance and specificity of the naive B cell repertoire contributes to understanding how to potentially elicit protective responses. Here, we isolated naive B cells from 8 seronegative human donors targeting the SARS-CoV-2 receptor-binding domain (RBD). Single B cell analysis showed diverse gene usage with no restricted complementarity determining region lengths. We show that recombinant antibodies engage SARS-CoV-2 RBD, circulating variants, and pre-emergent coronaviruses. Representative antibodies signal in a B cell activation assay and can be affinity matured through directed evolution. Structural analysis of a naive antibody in complex with spike shows a conserved mode of recognition shared with infection-induced antibodies. Lastly, both naive and affinity-matured antibodies can neutralize SARS-CoV-2. Understanding the naive repertoire may inform potential responses recognizing variants or emerging coronaviruses enabling the development of pan-coronavirus vaccines aimed at engaging germline responses., Competing Interests: Competing interests: Authors declare no competing interests.

Published
2021
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