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321 results on '"Morgagni, P"'

1. Genomic events stratifying prognosis of early gastric cancer

Author

Molinari, Chiara, Solaini, Leonardo, Rebuzzi, Francesca, Tedaldi, Gianluca, Angeli, Davide, Petracci, Elisabetta, Prascevic, Dusan, Ewald, Jan, Rahm, Erhard, Canale, Matteo, Giovanni, Martinelli, Tomezzoli, Anna, Bencivenga, Maria, Ambrosio, Maria Raffaella, Marrelli, Daniele, Morgagni, Paolo, Ercolani, Giorgio, Ulivi, Paola, and Saragoni, Luca

Published
2024
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2. International consensus on the management of metastatic gastric cancer: step by step in the foggy landscape: Bertinoro Workshop, November 2022

Author

Morgagni, Paolo, Bencivenga, Maria, Carneiro, Fatima, Cascinu, Stefano, Derks, Sarah, Di Bartolomeo, Maria, Donohoe, Claire, Eveno, Clarisse, Gisbertz, Suzanne, Grimminger, Peter, Gockel, Ines, Grabsch, Heike, Kassab, Paulo, Langer, Rupert, Lonardi, Sara, Maltoni, Marco, Markar, Sheraz, Moehler, Markus, Marrelli, Daniele, Mazzei, Maria Antonietta, Melisi, Davide, Milandri, Carlo, Moenig, Paul Stefan, Mostert, Bianca, Mura, Gianni, Polkowski, Wojciech, Reynolds, John, Saragoni, Luca, Van Berge Henegouwen, Mark I., Van Hillegersberg, Richard, Vieth, Michael, Verlato, Giuseppe, Torroni, Lorena, Wijnhoven, Bas, Tiberio, Guido Alberto Massimo, Yang, Han-Kwang, Roviello, Franco, and de Manzoni, Giovanni

Published
2024
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3. Correction: International consensus on the management of metastatic gastric cancer: step by step in the foggy landscape

Author

Morgagni, Paolo, Bencivenga, Maria, Carneiro, Fatima, Cascinu, Stefano, Derks, Sarah, Di Bartolomeo, Maria, Donohoe, Claire, Eveno, Clarisse, Gisbertz, Suzanne, Grimminger, Peter, Gockel, Ines, Grabsch, Heike, Kassab, Paulo, Langer, Rupert, Lonardi, Sara, Maltoni, Marco, Markar, Sheraz, Moehler, Markus, Marrelli, Daniele, Mazzei, Maria Antonietta, Melisi, Davide, Milandri, Carlo, Moenig, Paul Stefan, Mostert, Bianca, Mura, Gianni, Polkowski, Wojciech, Reynolds, John, Saragoni, Luca, Van Berge Henegouwen, Mark I., Van Hillegersberg, Richard, Vieth, Michael, Verlato, Giuseppe, Torroni, Lorena, Wijnhoven, Bas, Tiberio, Guido Alberto Massimo, Yang, Han-Kwang, Roviello, Franco, and de Manzoni, Giovanni

Published
2024
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6. Clinical outcomes of patients with complicated post-operative course after gastrectomy for cancer: a GIRCG study using the GASTRODATA registry

Author

Baiocchi, Gian Luca, Giacopuzzi, Simone, Vittimberga, Giovanni, De Pascale, Stefano, Pastorelli, Elisabetta, Gelmini, Roberta, Viganò, Jacopo, Graziosi, Luigina, Vagliasindi, Alessio, Rosa, Fausto, Steccanella, Francesca, Demartini, Paolo, Reddavid, Rossella, Berselli, Mattia, Elmore, Ugo, Romario, Uberto Fumagalli, Degiuli, Maurizio, Morgagni, Paolo, Marrelli, Daniele, D’Ugo, Domenico, Rosati, Riccardo, and De Manzoni, Giovanni

Published
2023
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7. Structured and shared CT radiological report of gastric cancer: a consensus proposal by the Italian Research Group for Gastric Cancer (GIRCG) and the Italian Society of Medical and Interventional Radiology (SIRM)

Author

Mazzei, Maria Antonietta, Bagnacci, Giulio, Gentili, Francesco, Capitoni, Iacopo, Mura, Gianni, Marrelli, Daniele, Petrioli, Roberto, Brunese, Luca, Cappabianca, Salvatore, Catarci, Marco, Degiuli, Maurizio, De Manzoni, Giovanni, De Prizio, Marco, Donini, Annibale, Romario, Uberto Fumagalli, Funicelli, Luigi, Laghi, Andrea, Minetti, Giuseppe, Morgagni, Paolo, Petrella, Enrico, Pittiani, Frida, Rausei, Stefano, Romanini, Laura, Rosati, Riccardo, Ianora, Amato Antonio Stabile, Tiberio, Guido A. M., Volterrani, Luca, Roviello, Franco, and Grassi, Roberto

Published
2022
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8. Reconstruction Techniques and Associated Morbidity in Minimally Invasive Gastrectomy for Cancer

Author

Schneider, Marcel André, Kim, Jeesun, Berlth, Felix, Sugita, Yutaka, Grimminger, Peter P., Wijnhoven, Bas P.L., Overtoom, Hidde, Gockel, Ines, Thieme, René, Griffiths, Ewen A., Butterworth, William, Nienhüser, Henrik, Müller, Beat, Crnovrsanin, Nerma, Gero, Daniel, Nickel, Felix, Gisbertz, Suzanne, van Berge Henegouwen, Mark I., Pucher, Philip H., Khan, Kashuf, Chaudry, Asif, Patel, Pranav H., Pera, Manuel, Dal Cero, Mariagiulia, Garcia, Carlos, Martinez Salinas, Guillermo, Kassab, Paulo, Prado Castro, Osvaldo Antônio, Norero, Enrique, Wisniowski, Paul, Putnam, Luke Randall, Lombardi, Pietro Maria, Ferrari, Giovanni, Gudaityte, Rita, Maleckas, Almantas, Prodehl, Leanne, Castaldi, Antonio, Prudhomme, Michel, Lee, Hyuk-Joon, Sano, Takeshi, Baiocchi, Gian Luca, De Manzoni, Giovanni, Giacopuzzi, Simone, Bencivenga, Maria, Rosati, Riccardo, Puccetti, Francesco, D’Ugo, Domenico, Nunobe, Souya, Yang, Han-Kwang, Gutschow, Christian Alexander, Piessen, Guillaume, Lerooy, Justine, van Sandick, Johanna Wilhelmina, Reynolds, John V., Morgagni, Paolo, Hölscher, Arnulf H., Hemmerich, Martin, Mönig, Stefan, Chevallay, Mickael, Kołodziejczyk, Piotr, Hartgrink, Henk, da Costa, Paulo Matos, Borges, Filipe Castro, Davies, Andrew, Baker, Cara, Allum, William, Kumar, Sacheen, Polkowski, Wojciech, Rawicz-Pruszyński, Karol, Romario, Uberto Fumagalli, De Pascale, Stefano, Tarasconi, Antonio, Reim, Daniel, Pergolini, Ilaria, Santos, Lucio Lara, Martins, Pedro Carvalho, Biondi, Alberto, Degiuli, Maurizio, Reddavid, Rossella, Kielan, Wojciech, Schneider, Paul Magnus, and Murphy, Thomas

Published
2024
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9. Early Gastric Cancer: identification of molecular markers able to distinguish submucosa-penetrating lesions with different prognosis

Author

Molinari, Chiara, Tedaldi, Gianluca, Rebuzzi, Francesca, Morgagni, Paolo, Capelli, Laura, Ravaioli, Sara, Tumedei, Maria Maddalena, Scarpi, Emanuela, Tomezzoli, Anna, Bernasconi, Riccardo, Ambrosio, Maria Raffaella, D’Ignazio, Alessia, Solaini, Leonardo, Limarzi, Francesco, Ercolani, Giorgio, Martinelli, Giovanni, Ulivi, Paola, and Saragoni, Luca

Published
2021
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10. Looking for a strategy in treating peritoneal gastric cancer carcinomatosis: an Italian multicenter Gastric Cancer Research group’s analysis

Author

Graziosi, Luigina, Marino, Elisabetta, Bencivenga, Maria, D’Ignazio, Alessia, Solaini, Leonardo, Ministrini, Silvia, Caprioli, Michela, Sacco, Michele, Marrelli, Daniele, Mura, Gianni, Degiuli, Maurizio, Morgagni, Paolo, Tiberio, Guido Alberto Massimo, De Manzoni, Giovanni, Roviello, Franco, and Donini, Annibale

Published
2021
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12. International consensus on a complications list after gastrectomy for cancer

Author

Baiocchi, Gian Luca, Giacopuzzi, Simone, Marrelli, Daniele, Reim, Daniel, Piessen, Guillaume, Matos da Costa, Paulo, Reynolds, John V., Meyer, Hans-Joachim, Morgagni, Paolo, Gockel, Ines, Lara Santos, Lucio, Jensen, Lone Susanne, Murphy, Thomas, Preston, Shaun R., Ter-Ovanesov, Mikhail, Fumagalli Romario, Uberto, Degiuli, Maurizio, Kielan, Wojciech, Mönig, Stefan, Kołodziejczyk, Piotr, Polkowski, Wojciech, Hardwick, Richard, Pera, Manuel, Johansson, Jan, Schneider, Paul M., de Steur, Wobbe O., Gisbertz, Suzanne S., Hartgrink, Henk, van Sandick, Joanna W., Portolani, Nazario, Hölscher, Arnulf H., Botticini, Maristella, Roviello, Franco, Mariette, Christophe, Allum, William, and De Manzoni, Giovanni

Published
2019
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14. Open versus laparoscopic gastrectomy for advanced gastric cancer: a propensity score matching analysis of survival in a western population—on behalf of the Italian Research Group for Gastric Cancer

Author

Lombardi, P, Bernasconi, D, Baiocchi, G, Berselli, M, Biondi, A, Castoro, C, Catarci, M, Degiuli, M, Fumagalli Romario, U, Giacopuzzi, S, Marchesi, F, Marrelli, D, Mazzola, M, Molfino, S, Olmi, S, Rausei, S, Rosa, F, Rosati, R, Roviello, F, Santi, S, Solaini, L, Staderini, F, Vigano, J, Ferrari, G, Agnes, A, Alfieri, S, Alloggio, M, Bencivenga, M, Benedetti, M, Bottari, A, Cianchi, F, Cocozza, E, Dalmonte, G, De Martini, P, De Pascale, S, Desio, M, Emiliani, G, Ercolani, G, Galli, F, Garosio, I, Giani, A, Gualtierotti, M, Marano, L, Morgagni, P, Peri, A, Puccetti, F, Reddavid, R, Uccelli, M, Lombardi P. M., Bernasconi D., Baiocchi G. L., Berselli M., Biondi A., Castoro C., Catarci M., Degiuli M., Fumagalli Romario U., Giacopuzzi S., Marchesi F., Marrelli D., Mazzola M., Molfino S., Olmi S., Rausei S., Rosa F., Rosati R., Roviello F., Santi S., Solaini L., Staderini F., Vigano J., Ferrari G., Agnes A., Alfieri S., Alloggio M., Bencivenga M., Benedetti M., Bottari A., Cianchi F., Cocozza E., Dalmonte G., De Martini P., De Pascale S., Desio M., Emiliani G., Ercolani G., Galli F., Garosio I., Giani A., Gualtierotti M., Marano L., Morgagni P., Peri A., Puccetti F., Reddavid R., Uccelli M., Lombardi, P, Bernasconi, D, Baiocchi, G, Berselli, M, Biondi, A, Castoro, C, Catarci, M, Degiuli, M, Fumagalli Romario, U, Giacopuzzi, S, Marchesi, F, Marrelli, D, Mazzola, M, Molfino, S, Olmi, S, Rausei, S, Rosa, F, Rosati, R, Roviello, F, Santi, S, Solaini, L, Staderini, F, Vigano, J, Ferrari, G, Agnes, A, Alfieri, S, Alloggio, M, Bencivenga, M, Benedetti, M, Bottari, A, Cianchi, F, Cocozza, E, Dalmonte, G, De Martini, P, De Pascale, S, Desio, M, Emiliani, G, Ercolani, G, Galli, F, Garosio, I, Giani, A, Gualtierotti, M, Marano, L, Morgagni, P, Peri, A, Puccetti, F, Reddavid, R, Uccelli, M, Lombardi P. M., Bernasconi D., Baiocchi G. L., Berselli M., Biondi A., Castoro C., Catarci M., Degiuli M., Fumagalli Romario U., Giacopuzzi S., Marchesi F., Marrelli D., Mazzola M., Molfino S., Olmi S., Rausei S., Rosa F., Rosati R., Roviello F., Santi S., Solaini L., Staderini F., Vigano J., Ferrari G., Agnes A., Alfieri S., Alloggio M., Bencivenga M., Benedetti M., Bottari A., Cianchi F., Cocozza E., Dalmonte G., De Martini P., De Pascale S., Desio M., Emiliani G., Ercolani G., Galli F., Garosio I., Giani A., Gualtierotti M., Marano L., Morgagni P., Peri A., Puccetti F., Reddavid R., and Uccelli M.

Abstract

Background: Oncologic outcomes after laparoscopic gastrectomy for advanced gastric cancer in the West have been poorly investigated. The aim of the present study was to compare survival outcomes in patients undergoing curative-intent laparoscopic and open gastrectomy for advanced gastric cancer in several centres belonging to the Italian Research Group for Gastric Cancer. Methods: Data of patients operated between 2015 and 2018 were retrospectively analysed. Propensity Score Matching was performed to balance baseline characteristics of patients undergoing laparoscopic and open gastrectomy. The primary endpoint was 3-year overall survival. Secondary endpoints were 3-year disease-free survival and short-term outcomes. Multivariable regression analyses for survival were conducted. Results: Data were retrieved from 20 centres. Of the 717 patients included, 438 patients were correctly matched, 219 per group. The 3-year overall survival was 73.6% and 68.7% in the laparoscopic and open group, respectively (p = 0.40). When compared with open gastrectomy, laparoscopic gastrectomy showed comparable 3-year disease-free survival (62.8%, vs 58.9%, p = 0.40), higher rate of return to intended oncologic treatment (56.9% vs 40.2%, p = 0.001), similar 30-day morbidity/mortality. Prognostic factors for survival were ASA Score ≥ 3, age-adjusted Charlson Comorbidity Index ≥ 5, lymph node ratio ≥ 0.15, p/ypTNM Stage III and return to intended oncologic treatment. Conclusions: Laparoscopic gastrectomy for advanced gastric cancer offers similar rates of survival when compared to open gastrectomy, with higher rates of return to intended oncologic treatment. ASA score, age-adjusted Charlson Comorbidity Index, lymph node ratio, return to intended oncologic treatment and p/ypTNM Stage, but not surgical approach, are prognostic factors for survival.

Published
2022

15. Current practice on the use of prophylactic drain after gastrectomy in Italy: the Abdominal Drain in Gastrectomy (ADiGe) survey

Author

Mengardo, V, Weindelmayer, J, Veltri, A, Giacopuzzi, S, Torroni, L, de Manzoni, G, Agresta, F, Alfieri, R, Alfieri, S, Antonacci, N, Baiocchi, G, Bencini, L, Bencivenga, M, Benedetti, M, Berselli, M, Biondi, A, Capolupo, G, Carboni, F, Casadei, R, Casella, F, Catarci, M, Cerri, P, Chiari, D, Cocozza, E, Colombo, G, Cozzaglio, L, Dalmonte, G, Degiuli, M, De Luca, M, De Luca, R, De Manzini, N, De Pasqual, C, De Pascale, S, De Ruvo, N, Di Cosmo, M, Di Leo, A, Di Paola, M, Elio, A, Ferrara, F, Ferrari, G, Fiscon, V, Fumagalli, U, Garulli, G, Gennai, A, Gentile, I, Germani, P, Gualtierotti, M, Guerini, F, Gurrado, A, Inama, M, La Torre, F, Laterza, E, Losurdo, P, Macri, A, Marano, A, Marano, L, Marchesi, F, Marino, F, Massani, M, Menghi, R, Milone, M, Molfino, S, Montuori, M, Moretto, G, Morgagni, P, Morpurgo, E, Abdallah, M, Nespoli, L, Olmi, S, Palaia, R, Pallabazer, G, Parise, P, Pasculli, A, Pericoli Ridolfini, M, Pesce, A, Pinotti, E, Pisano, M, Poiasina, E, Postiglione, V, Rausei, S, Rella, A, Rosa, F, Rosati, R, Rossi, G, Rossit, L, Rovatti, M, Ruspi, L, Sacco, L, Saladino, E, Sansonetti, A, Sartori, A, Scaglione, D, Scaringi, S, Schoenthaler, C, Sena, G, Simone, M, Solaini, L, Strignano, P, Tartaglia, N, Testa, S, Testini, M, Tiberio, G, Treppiedi, E, Vagliasindi, A, Valmasoni, M, Vigano, J, Zanchettin, G, Zanoni, A, Zardini, C, Zerbinati, A, Mengardo V., Weindelmayer J., Veltri A., Giacopuzzi S., Torroni L., de Manzoni G., Agresta F., Alfieri R., Alfieri S., Antonacci N., Baiocchi G. L., Bencini L., Bencivenga M., Benedetti M., Berselli M., Biondi A., Capolupo G. T., Carboni F., Casadei R., Casella F., Catarci M., Cerri P., Chiari D., Cocozza E., Colombo G., Cozzaglio L., Dalmonte G., Degiuli M., De Luca M., De Luca R., De Manzini N., De Pasqual C. A., De Pascale S., De Ruvo N., Di Cosmo M., Di Leo A., Di Paola M., Elio A., Ferrara F., Ferrari G., Fiscon V., Fumagalli U., Garulli G., Gennai A., Gentile I., Germani P., Gualtierotti M., Guerini F., Gurrado A., Inama M., La Torre F., Laterza E., Losurdo P., Macri A., Marano A., Marano L., Marchesi F., Marino F., Massani M., Menghi R., Milone M., Molfino S., Montuori M., Moretto G., Morgagni P., Morpurgo E., Abdallah M., Nespoli L., Olmi S., Palaia R., Pallabazer G., Parise P., Pasculli A., Pericoli Ridolfini M., Pesce A., Pinotti E., Pisano M., Poiasina E., Postiglione V., Rausei S., Rella A., Rosa F., Rosati R., Rossi G., Rossit L., Rovatti M., Ruspi L., Sacco L., Saladino E., Sansonetti A., Sartori A., Scaglione D., Scaringi S., Schoenthaler C., Sena G., Simone M., Solaini L., Strignano P., Tartaglia N., Testa S., Testini M., Tiberio G. A. M., Treppiedi E., Vagliasindi A., Valmasoni M., Vigano J., Zanchettin G., Zanoni A., Zardini C., Zerbinati A., Mengardo, V, Weindelmayer, J, Veltri, A, Giacopuzzi, S, Torroni, L, de Manzoni, G, Agresta, F, Alfieri, R, Alfieri, S, Antonacci, N, Baiocchi, G, Bencini, L, Bencivenga, M, Benedetti, M, Berselli, M, Biondi, A, Capolupo, G, Carboni, F, Casadei, R, Casella, F, Catarci, M, Cerri, P, Chiari, D, Cocozza, E, Colombo, G, Cozzaglio, L, Dalmonte, G, Degiuli, M, De Luca, M, De Luca, R, De Manzini, N, De Pasqual, C, De Pascale, S, De Ruvo, N, Di Cosmo, M, Di Leo, A, Di Paola, M, Elio, A, Ferrara, F, Ferrari, G, Fiscon, V, Fumagalli, U, Garulli, G, Gennai, A, Gentile, I, Germani, P, Gualtierotti, M, Guerini, F, Gurrado, A, Inama, M, La Torre, F, Laterza, E, Losurdo, P, Macri, A, Marano, A, Marano, L, Marchesi, F, Marino, F, Massani, M, Menghi, R, Milone, M, Molfino, S, Montuori, M, Moretto, G, Morgagni, P, Morpurgo, E, Abdallah, M, Nespoli, L, Olmi, S, Palaia, R, Pallabazer, G, Parise, P, Pasculli, A, Pericoli Ridolfini, M, Pesce, A, Pinotti, E, Pisano, M, Poiasina, E, Postiglione, V, Rausei, S, Rella, A, Rosa, F, Rosati, R, Rossi, G, Rossit, L, Rovatti, M, Ruspi, L, Sacco, L, Saladino, E, Sansonetti, A, Sartori, A, Scaglione, D, Scaringi, S, Schoenthaler, C, Sena, G, Simone, M, Solaini, L, Strignano, P, Tartaglia, N, Testa, S, Testini, M, Tiberio, G, Treppiedi, E, Vagliasindi, A, Valmasoni, M, Vigano, J, Zanchettin, G, Zanoni, A, Zardini, C, Zerbinati, A, Mengardo V., Weindelmayer J., Veltri A., Giacopuzzi S., Torroni L., de Manzoni G., Agresta F., Alfieri R., Alfieri S., Antonacci N., Baiocchi G. L., Bencini L., Bencivenga M., Benedetti M., Berselli M., Biondi A., Capolupo G. T., Carboni F., Casadei R., Casella F., Catarci M., Cerri P., Chiari D., Cocozza E., Colombo G., Cozzaglio L., Dalmonte G., Degiuli M., De Luca M., De Luca R., De Manzini N., De Pasqual C. A., De Pascale S., De Ruvo N., Di Cosmo M., Di Leo A., Di Paola M., Elio A., Ferrara F., Ferrari G., Fiscon V., Fumagalli U., Garulli G., Gennai A., Gentile I., Germani P., Gualtierotti M., Guerini F., Gurrado A., Inama M., La Torre F., Laterza E., Losurdo P., Macri A., Marano A., Marano L., Marchesi F., Marino F., Massani M., Menghi R., Milone M., Molfino S., Montuori M., Moretto G., Morgagni P., Morpurgo E., Abdallah M., Nespoli L., Olmi S., Palaia R., Pallabazer G., Parise P., Pasculli A., Pericoli Ridolfini M., Pesce A., Pinotti E., Pisano M., Poiasina E., Postiglione V., Rausei S., Rella A., Rosa F., Rosati R., Rossi G., Rossit L., Rovatti M., Ruspi L., Sacco L., Saladino E., Sansonetti A., Sartori A., Scaglione D., Scaringi S., Schoenthaler C., Sena G., Simone M., Solaini L., Strignano P., Tartaglia N., Testa S., Testini M., Tiberio G. A. M., Treppiedi E., Vagliasindi A., Valmasoni M., Vigano J., Zanchettin G., Zanoni A., Zardini C., and Zerbinati A.

Abstract

Evidence against the use of prophylactic drain after gastrectomy are increasing and ERAS guidelines suggest the benefit of drain avoidance. Nevertheless, it is unclear whether this practice is still widespread. We conducted a survey among Italian surgeons through the Italian Gastric Cancer Research Group and the Polispecialistic Society of Young Surgeons, aiming to understand the current use of prophylactic drain. A 28-item questionnaire-based survey was developed to analyze the current practice and the individual opinion about the use of prophylactic drain after gastrectomy. Groups based on age, experience and unit volume were separately analyzed. Response of 104 surgeons from 73 surgical units were collected. A standardized ERAS protocol for gastrectomy was applied by 42% of the respondents. Most of the surgeons, regardless of age, experience, or unit volume, declared to routinely place one or more drain after gastrectomy. Only 2 (1.9%) and 7 surgeons (6.7%) belonging to high volume units, do not routinely place drains after total and subtotal gastrectomy, respectively. More than 60% of the participants remove the drain on postoperative day 4–6 after performing an assessment of the anastomosis integrity. Interestingly, less than half of the surgeons believe that drain is the main tool for leak management, and this percentage further drops among younger surgeons. On the other hand, drain’s role seems to be more defined for duodenal stump leak treatment, with almost 50% of the surgeons recognizing its importance. Routine use of prophylactic drain after gastrectomy is still a widespread practice even if younger surgeons are more persuaded that it could not be advantageous.

Published
2022

16. Textbook Oncological Outcome in European GASTRODATA.

Author

Sędłak, Katarzyna, Rawicz-Pruszyński, Karol, Mlak, Radosław, Van Sandick, Johanna, Gisbertz, Suzanne, Pera, Manuel, Cero, Mariagiulia Dal, Baiocchi, Gian Luca, Celotti, Andrea, Morgagni, Paolo, Vittimberga, Giovani, Hoelscher, Arnulf, Moenig, Stefan, Kołodziejczyk, Piotr, and Richter, Piotr

Abstract

Objective: To assess the rate of textbook outcome (TO) and textbook oncological outcome (TOO) in the European population based on the GASTRODATA registry. Background: TO is a composite parameter assessing surgical quality and strongly correlates with improved overall survival. Following the standard of treatment for locally advanced gastric cancer, TOO was proposed as a quality and optimal multimodal treatment parameter. Methods: TO was achieved when all the following criteria were met: no intraoperative complications, radical resection according to the surgeon, pR0 resection, retrieval of at least 15 lymph nodes, no severe postoperative complications, no reintervention, no admission to the intensive care unit, no prolonged length of stay, no postoperative mortality and no hospital readmission. TOO was defined as TO with the addition of perioperative chemotherapy compliance. Results: Of the 2558 patients, 1700 were included in the analysis. TO was achieved in 1164 (68.5%) patients. The use of neoadjuvant chemotherapy [odds ratio (OR) = 1.33, 95% CI: 1.04--1.70] and D2 or D2+ lymphadenectomy (OR = 1.55, 95% CI: 1.15--2.10) had a positive impact on TO achievement. Older age (OR = 0.73, 95% CI: 0.54--0.94), pT3/4 (OR = 0.79, 95% CI: 0.63--0.99), ASA 3/4 (OR = 0.68, 95% CI: 0.54--0.86) and total gastrectomy (OR = 0.56, 95% CI: 0.45--0.70), had a negative impact on TO achievement. TOO was achieved in 388 (22.8%) patients. Older age (OR = 0.37, 95% CI: 0.27--0.53), pT3 or pT4 (OR = 0.52, 95% CI: 0.39--0.69), and ASA 3 or 4 (OR = 0.58, 95% CI: 0.43--0.79) had a negative impact on TOO achievement. Conclusions: Despite successively improved surgical outcomes, stageappropriate chemotherapy in adherence to the current guidelines for multimodal treatment of gastric cancer remains poor. Further implementation of oncologic quality metrics should include greater emphasis on perioperative chemotherapy and adequate lymphadenectomy. [ABSTRACT FROM AUTHOR]

Published
2023
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17. Complications after gastrectomy for cancer: Italian perspective

Author

Baiocchi, Gian Luca, Giacopuzzi, Simone, Marrelli, Daniele, Bencivenga, Maria, Morgagni, Paolo, Rosa, Fausto, Berselli, Mattia, Orsenigo, Elena, Cananzi, Ferdinando, Tiberio, Guido, Rausei, Stefano, Cozzaglio, Luca, Degiuli, Maurizio, Di Leo, Alberto, Fumagalli, Uberto, Portolani, Nazario, Rosati, Riccardo, Roviello, Franco, De Manzoni, Giovanni, and On behalf of the Italian Research Group for Gastric Cancer (GIRCG)

Published
2017
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19. The Italian Research Group for Gastric Cancer (GIRCG) guidelines for gastric cancer staging and treatment: 2015

Author

De Manzoni, Giovanni, Marrelli, Daniele, Baiocchi, Gian Luca, Morgagni, Paolo, Saragoni, Luca, Degiuli, Maurizio, Donini, Annibale, Fumagalli, Uberto, Mazzei, Maria Antonietta, Pacelli, Fabio, Tomezzoli, Anna, Berselli, Mattia, Catalano, Filippo, Di Leo, Alberto, Framarini, Massimo, Giacopuzzi, Simone, Graziosi, Luigina, Marchet, Alberto, Marini, Mario, Milandri, Carlo, Mura, Gianni, Orsenigo, Elena, Quagliuolo, Vittorio, Rausei, Stefano, Ricci, Riccardo, Rosa, Fausto, Roviello, Giandomenico, Sansonetti, Andrea, Sgroi, Giovanni, Tiberio, Guido Alberto Massimo, Verlato, Giuseppe, Vindigni, Carla, Rosati, Riccardo, and Roviello, Franco

Published
2017
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20. Krukenberg Tumors of Gastric Origin: The Rationale of Surgical Resection and Perioperative Treatments in a Multicenter Western Experience

Author

Rosa, Fausto, Marrelli, Daniele, Morgagni, Paolo, Cipollari, Chiara, Vittimberga, Giovanni, Framarini, Massimo, Cozzaglio, Luca, Pedrazzani, Corrado, Berardi, Stefano, Baiocchi, Gian Luca, Roviello, Franco, Portolani, Nazario, de Manzoni, Giovanni, Costamagna, Guido, Doglietto, Giovanni Battista, and Pacelli, Fabio

Published
2016
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21. Follow-up after gastrectomy for cancer: the Charter Scaligero Consensus Conference

Author

Baiocchi, Gian Luca, D’Ugo, Domenico, Coit, Daniel, Hardwick, Richard, Kassab, Paulo, Nashimoto, Atsushi, Marrelli, Daniele, Allum, William, Berruti, Alfredo, Chandramohan, Servarayan Murugesan, Coburn, Natalie, Gonzàlez-Moreno, Santiago, Hoelscher, Arnulf, Jansen, Edwin, Leja, Marcis, Mariette, Christophe, Meyer, Hans-Joachim, Mönig, Stefan, Morgagni, Paolo, Ott, Katia, Preston, Shaun, Rha, Sun Young, Roviello, Franco, Sano, Takeshi, Sasako, Mitsuru, Shimada, Hideaki, Schuhmacher, Cristoph, So Bok-yan, Jimmy, Strong, Vivian, Yoshikawa, Takaki, Terashima, Masanori, Ter-Ovanesov, Michail, Van der Velde, Cornelis, Memo, Maurizio, Castelli, Francesco, Pecorelli, Sergio, Detogni, Claudio, Kodera, Yasuhiro, and de Manzoni, Giovanni

Published
2016
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22. Surgical management of duodenal stump fistula after elective gastrectomy for malignancy: an Italian retrospective multicenter study

Author

Cozzaglio, Luca, Giovenzana, Marco, Biffi, Roberto, Cobianchi, Lorenzo, Coniglio, Arianna, Framarini, Massimo, Gerard, Leonardo, Gianotti, Luca, Marchet, Alberto, Mazzaferro, Vincenzo, Morgagni, Paolo, Orsenigo, Elena, Rausei, Stefano, Romano, Fabrizio, Rosa, Fausto, Rosati, Riccardo, Roviello, Francesco, Sacchi, Matteo, Morenghi, Emanuela, and Quagliuolo, Vittorio

Published
2016
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24. Open versus laparoscopic gastrectomy for advanced gastric cancer: a propensity score matching analysis of survival in a western population-on behalf of the Italian Research Group for Gastric Cancer

Author

Lombardi, P. M., Bernasconi, D., Baiocchi, G. L., Berselli, M., Biondi, Alberto, Castoro, C., Catarci, Marco, Degiuli, M., Fumagalli Romario, U., Giacopuzzi, S., Marchesi, F., Marrelli, D., Mazzola, M., Molfino, S., Olmi, S., Rausei, S., Rosa, Fausto, Rosati, R., Roviello, F., Santi, Samuele, Solaini, L., Staderini, F., Vigano, J., Ferrari, G., Agnes, Annamaria, Alfieri, Sergio, Alloggio, M., Bencivenga, M., Benedetti, M., Bottari, A., Cianchi, F., Cocozza, E., Dalmonte, G., De Martini, P., De Pascale, S., Desio, M., Emiliani, G., Ercolani, G., Galli, F., Garosio, I., Giani, A., Gualtierotti, M., Marano, L., Morgagni, P., Peri, A., Puccetti, F., Reddavid, R., Uccelli, M., Biondi A. (ORCID:0000-0002-2470-7858), Catarci M., Rosa F. (ORCID:0000-0002-7280-8354), Santi S., Agnes A., Alfieri S. (ORCID:0000-0002-0404-724X), Lombardi, P. M., Bernasconi, D., Baiocchi, G. L., Berselli, M., Biondi, Alberto, Castoro, C., Catarci, Marco, Degiuli, M., Fumagalli Romario, U., Giacopuzzi, S., Marchesi, F., Marrelli, D., Mazzola, M., Molfino, S., Olmi, S., Rausei, S., Rosa, Fausto, Rosati, R., Roviello, F., Santi, Samuele, Solaini, L., Staderini, F., Vigano, J., Ferrari, G., Agnes, Annamaria, Alfieri, Sergio, Alloggio, M., Bencivenga, M., Benedetti, M., Bottari, A., Cianchi, F., Cocozza, E., Dalmonte, G., De Martini, P., De Pascale, S., Desio, M., Emiliani, G., Ercolani, G., Galli, F., Garosio, I., Giani, A., Gualtierotti, M., Marano, L., Morgagni, P., Peri, A., Puccetti, F., Reddavid, R., Uccelli, M., Biondi A. (ORCID:0000-0002-2470-7858), Catarci M., Rosa F. (ORCID:0000-0002-7280-8354), Santi S., Agnes A., and Alfieri S. (ORCID:0000-0002-0404-724X)

Abstract

Background Oncologic outcomes after laparoscopic gastrectomy for advanced gastric cancer in the West have been poorly investigated. The aim of the present study was to compare survival outcomes in patients undergoing curative-intent laparoscopic and open gastrectomy for advanced gastric cancer in several centres belonging to the Italian Research Group for Gastric Cancer. Methods Data of patients operated between 2015 and 2018 were retrospectively analysed. Propensity Score Matching was performed to balance baseline characteristics of patients undergoing laparoscopic and open gastrectomy. The primary endpoint was 3-year overall survival. Secondary endpoints were 3-year disease-free survival and short-term outcomes. Multivariable regression analyses for survival were conducted. Results Data were retrieved from 20 centres. Of the 717 patients included, 438 patients were correctly matched, 219 per group. The 3-year overall survival was 73.6% and 68.7% in the laparoscopic and open group, respectively (p = 0.40). When compared with open gastrectomy, laparoscopic gastrectomy showed comparable 3-year disease-free survival (62.8%, vs 58.9%, p = 0.40), higher rate of return to intended oncologic treatment (56.9% vs 40.2%, p = 0.001), similar 30-day morbidity/mortality. Prognostic factors for survival were ASA Score >= 3, age-adjusted Charlson Comorbidity Index >= 5, lymph node ratio >= 0.15, p/ypTNM Stage III and return to intended oncologic treatment. Conclusions Laparoscopic gastrectomy for advanced gastric cancer offers similar rates of survival when compared to open gastrectomy, with higher rates of return to intended oncologic treatment. ASA score, age-adjusted Charlson Comorbidity Index, lymph node ratio, return to intended oncologic treatment and p/ypTNM Stage, but not surgical approach, are prognostic factors for survival.

Published
2022

25. Consequences of the COVID-19 pandemic on the diagnosis and treatment of gastric cancer in referral centers in Italy

Author

Solaini, L., Bencivenga, M., Rosa, Fausto, D'Ignazio, A., Marino, E., Ministrini, S., Sofia, S., Sacco, M., Mura, G., Rausa, E., Prizio, M. D., Graziosi, L., Degiuli, M., Tiberio, G. A. M., Alfieri, Sergio, Marrelli, D., Morgagni, P., Ercolani, G., Rosa F. (ORCID:0000-0002-7280-8354), Alfieri S. (ORCID:0000-0002-0404-724X), Solaini, L., Bencivenga, M., Rosa, Fausto, D'Ignazio, A., Marino, E., Ministrini, S., Sofia, S., Sacco, M., Mura, G., Rausa, E., Prizio, M. D., Graziosi, L., Degiuli, M., Tiberio, G. A. M., Alfieri, Sergio, Marrelli, D., Morgagni, P., Ercolani, G., Rosa F. (ORCID:0000-0002-7280-8354), and Alfieri S. (ORCID:0000-0002-0404-724X)

Abstract

Background: The coronavirus pandemic had a major impact in Italy. The Italian health system’s re-organization to face the emergency may have led to significant consequences especially in the diagnosis and treatment of malignancies. This study aimed to assess the impact of the pandemic in the diagnosis and treatment of gastric cancer in nine Gruppo Italiano RIcerca Cancro Gastrico (GIRCG) centers. Methods: All patients assessed for gastric adenocarcinoma at nine GIRCG centers between January 2019 and November 2020 were included. Patients were grouped according to the date of “patient 1’s” diagnosis in Italy: preCOVID versus COVID. Clinico-pathological and outcome differences between the two groups were analyzed. Results: A total of 632 patients were included in the analysis (205 in the COVID group). The cT4 weighted ratios were higher in 2020 from April to September, with the greatest differences in May, August and September. The cM+ weighted ratio was significantly higher in July 2020. The mean number of gastrectomies had the greatest reduction in March and May 2020 compared with 2019. The median times from diagnosis to chemotherapy, to complete diagnostic work-up or to operation were longer in 2019. The median time from the end of chemotherapy to surgery was 17 days longer in the preCOVID group. Conclusions: A greater number of advanced or metastatic cases were diagnosed after the spread of SARS-CoV-2 infection, especially after the “full lockdown” periods. During the pandemic, once gastric cancer patients were referred to one of the centers, a shorter time to complete the diagnostic work-up or to address them to the best treatment option was required.

Published
2022

26. 62: WHICH GASTRIC CANCER PATIENTS COULD BENEFIT FROM STAGING LAPAROSCOPY? A GIRCG MULTICENTER COHORT STUDY

Author

Solaini, L, primary, Bencivenga, M, additional, D’Ignazio, A, additional, Milone, M, additional, Marino, E, additional, De Pascale, S, additional, Rosa, F, additional, Sacco, M, additional, Fumagalli Romario, U, additional, Graziosi, L, additional, De Palma, G, additional, Marrelli, D, additional, Morgagni, P, additional, and Ercolani, G, additional

Published
2022
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30. Follow-Up After Gastrectomy for Cancer: An Appraisal of the Italian Research Group for Gastric Cancer

Author

Baiocchi, Gian Luca, Marrelli, Daniele, Verlato, Giuseppe, Morgagni, Paolo, Giacopuzzi, Simone, Coniglio, Arianna, Marchet, Alberto, Rosa, Fausto, Capponi, Michela Giulii, Di Leo, Alberto, Saragoni, Luca, Ansaloni, Luca, Pacelli, Fabio, Nitti, Donato, D’Ugo, Domenico, Roviello, Franco, Tiberio, Guido A. M., Giulini, Stefano M., and De Manzoni, Giovanni

Published
2014
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31. The SIC-GIRCG 2013 Consensus Conference on Gastric Cancer

Author

De Manzoni, Giovanni, Baiocchi, Gian Luca, Framarini, Massimo, De Giuli, Maurizio, D’Ugo, Domenico, Marchet, Alberto, Nitti, Donato, Marrelli, Daniele, Morgagni, Paolo, Rinnovati, Andrea, Rosati, Riccardo, Roviello, Franco, Allieta, Rosaldo, Berti, Stefano, Bracale, Umberto, Capelli, Patrizio, Cavicchi, Angelo, Di Martino, Natale, Donini, Annibale, Filippini, Angelo, Francioni, Gianfranco, Frascio, Marco, Garofalo, Alfredo, Giulini, Stefano Maria, Grassi, Giovanni Battista, Innocenti, Paolo, Martino, Antonio, Mazzocconi, Gualtiero, Mazzola, Lorenzo, Montemurro, Severino, Palasciano, Nicola, Pantuso, Gianni, Pernthaler, Heinrich, Petri, Roberto, Piazza, Diego, Sacco, Rosario, Sgroi, Giovanni, Staudacher, Carlo, Testa, Michele, Vallicelli, Carlo, Vettoretto, Nereo, Zingaretti, Costantino, Capussotti, Lorenzo, Morino, Mario, and Verdecchia, Giorgio Maria

Published
2014
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32. Surgical management of oncologic patient during and after the COVID-19 outbreak: practical recommendations from the Italian society of Surgical Oncology

Author

Cavaliere, D., Parini, D., Marano, L., Cipriani, F., Di Marzo, F., Macri, A., D'Ugo, D., Roviello, F., Gronchi, A., Lorenzon, L., De Luca, R., Boggi, U., Torzilli, G., Folli, S., Restivo, A., Spolverato, G., Garofalo, A., Lissidini, G., Dessena, M., Girelli, R., Sorrenti, S., Fumagalli Romario, U., Morgagni, P., Rastrelli, M., Cananzi, F., Degiuli, M., Simone, M., Donini, A., Muratore, A., Belluco, C., Ercolani, G., Cavaliere D., Parini D., Marano L., Cipriani F., Di Marzo F., Macri A., D'Ugo D., Roviello F., Gronchi A., Lorenzon L., De Luca R., Boggi U., Torzilli G., Folli S., Restivo A., Spolverato G., Garofalo A., Lissidini G., Dessena M., Girelli R., Sorrenti S., Fumagalli Romario U., Morgagni P., Rastrelli M., Cananzi F., Degiuli M., Simone M., Donini A., Muratore A., Belluco C., and Ercolani G.

Subjects
medicine.medical_specialty, Telemedicine, medicine.medical_treatment, Scientific literature, Recommendations, Rationalization (economics), Phase (combat), Cancer, COVID-19, Oncologic surgery, Multidisciplinary approach, Surgical oncology, Neoplasms, Pandemic, Medicine, Humans, Neoadjuvant therapy, COVID-19 · Cancer, Infection Control, business.industry, Patient Selection, COVID-19 · Cancer, Recommendations, Oncologic surgery, medicine.disease, Surgery, Surgical Oncology, Italy, Practice Guidelines as Topic, Original Article, Medical emergency, business
Abstract

The recent outbreak of COVID-19 in Italy caused a limitation of the resources of the health system, which necessarily led to their rationalization in the critical phase (phase 1) and a reorganization of the system in the following phase (phase 2). The Italian Society of Oncological Surgery–SICO has drafted these practical recommendations, calibrated on the most recent scientific literature and taking into account current health regulations and common sense. Surgical activity during phase 1 and 2 should follow a dynamic model, considering architectural structures, hospital mission, organizational models. Surgical delay should not affect oncological prognosis. However, COVID-19-positive cancer patients should be postponed until the infection is cured. The patients to consider more carefully before delaying surgery are those who have completed neoadjuvant therapy, patients with high biological aggressiveness tumors or without therapeutic alternatives. The multidisciplinary discussions are fundamental for sharing clinical decisions; videoconference meetings are preferable and use of telemedicine for follow-up is recommended. Especially in phase 1, maximum effort must be made to reduce the spread of the pandemic. Prefer intra-corporeal rather than open anastomosis during laparoscopy and mechanical rather than hand-sewn anastomosis in open surgery. Consider PPE for caregivers during stoma management. Minimal invasive surgery is not discouraged, because there is little evidence for augmented risk. Specific procedures have to be followed and use of energy devices has to be limited. Training programs with COVID-19 + patients are not recommended. All staff in OR should be trained with specific courses on specific PPE use. Differentiate recommendations are presented for every district cancer. Surgical oncology during phase 2 should be guaranteed by individual and distinct protocols and pathways between cancer patients and COVID-19 + patients with resources specifically addressed to the two distinct kind of patients to limit diagnostic/therapeutic interferences or slowdowns. These recommendations are based on currently available evidence about management of oncologic patients during COVID-19 pandemic, were endorsed by the SICO Executive Board, and are considered suitable for nationwide diffusion. They will be subject to updates and revisions in case of new and relevant scientific acquisitions.

Published
2021

34. Core Outcome Set for Surgical Trials in Gastric Cancer (GASTROS Study):International patient and healthcare professional consensus

Author

Alkhaffaf, B, Metryka, A, Blazeby, J M, Glenny, A-M, Adeyeye, A, Costa, P M, Diez Del Val, I, Gisbertz, S S, Guner, A, Law, S, Lee, H-J, Li, Z, Nakada, K, Reim, D, Vorwald, P, Baiocchi, G L, Allum, W, Chaudry, M A, Griffiths, E A, Williamson, P R, Bruce, I A, Li, S., He, Yl, Xu, Z., Xue, Y., Liang, H., Li, G., Zhao, E., Neumann, P., O’Neill, L., Guinan, E., Zanotti, D., de Manzoni, G., Hagens, Erc., van Berge Henegouwen, Mi., Lages, P., Onofre, S., Restrepo Nunez, Rm., Salcedo Cabanas, G., Posada Gonzalez, M., Marin Campos, C., Candas, B., Emre Baki, B., Selim Bodur, M., Yildirim, R., Burak Cekic, A., Brown, J., Hayes, K., Daher, I., Gianchandani Moorjani, Rh., Adetoyese Adeyeye, A., Sulaiman Olayide, A., Mitsuo Leon-Takahashi, A., Pueyo Rabanal, A., Peri, A., Boddy, A., Novotny, A., Charalabopoulos, A., Alemdar, A., Souadka, A., Rodrigues Gomes, Am., Lazaro, A., Maciel Da Silva, A., do Rosario da Conceicao Silva e Santos, A., Guidi, A., Silva Bernardes, Aj., Quinn, A., Isik, A., A Slipek, A., Candas Altinbas, B., Johnson Alegbeleye, B., Wool Eom, B., Frittoli, B., Lonsdale, B., Rogers, B., Ammori, Bj., Rau, B., Molteni, B., Byrne, Be., Villacıs- Bermeo, Ba., Villacıs Gallardo, Be., Kose, B., Sampedro Nogueira, Cj., Loureiro, C., Oliveira de Sousa, Cm., Collins, Cg., Nonso Ekwunife, C., Chukwunwendu Osuagwu, C., Wong, Cly., Winkler, C., Reim, D., Kjær, Dw., Cooper, D., Horner, D., Irvine, D., Bowrey, Dj., Chuter, Dj., Elliot, D., Mcghee, D., Toth, D., Ofner, D., Manatakis, Dk., Silveira Martins, Dr., Belt, Ejt., Cattaneo, E., Samadov, E., Colak, E., Treppiedi, E., Guglielmi, E., Redondo- Villahoz, E., Ciferri, E., Tiemens-de Graaf, E., Cocozza, E., Pape, E., Drozdov, Es., Enrico, F., Rashid, F., Sandri, Marco, Rosa, F., Mingol Navarro, F., Simionato Perrotta, F., Chan, Fsy., Saavedra Tomasich, Fd., Takeda, Fr., Farrell, F., Olanike Wuraola, F., Rosero, G., Bevilacqua, G., Baronio, G., Mura, G., D’Eugenio, G., Ortega-Perez, G., Tilt, G., Sutcliffe, G., Mureddu, G., Guerra Jacob, G., Daneri, H., Olufemi Gbenga, H., Okabe, H., Kingsford Smith, I., Olawale Lateef, I., Garosio, I., Hatipoglu, I., Gockel, I., Negoi, I., Min, Ish., Mesquita, Imm., Diez del Val, I., Leemhuis, Jhf., Gossage, Ja., Weindelmayer, J., Izbicki, Jr., McKenzie Manson, J., Kelly, J., Stoot, Jhmb., Haveman, Jw., Brown, Jd., Sultan, J., Hassall, J., van Sandick, J., Saunders, Jh., Clarke, Jk., Heisterkamp, J., Vargas, Ji., Couselo Villanueva, Jm., Ingmire, J., Mcewen, J., Galindo Alvarez, J., Turner, J., Peng, J., Roberts, K., Brandon, Kg., Mitchell, K., Mccarthy, K., Akhtar, K., Mikhailovich, Kn., Corbelli, L., Medeiros Milhomem, L., Solaini, L., Fengyuan, L., Xinchun, L., Timmermans, L., Porritt, L., Taglietti, L., Bonavina, L., F. Pinheiro L., de los Angeles Mayo Ossorio, M., Schiavo, M., Marchesiello, M., das Dores Vieira Leite, M., Demois, M., Di Felice, Mt., de Sousa, Md., Takahashi, M., Forshaw, M., Berselli, M., Paro, M., Usta, Ma., Yan, Mh., Pinchin, M., Caprioli, M., Rubbini, M., Cowen, M., Herrera Servin, Ma., Li, Mz., Sasako, M., Shukri Jahit, M., Ngonyoku Muhinga, M., Tareen, Ma., Ahmad, Mf., Bodur, Ms., Kaban, M., Farooq, N., Coburn, N., Cooper, N., Blencowe, Ns., Loria, N., de Vries, N., Adami Andreollo, N., Koksal, N., Zanini, N., Kreuser, N., Okkabaz, N., Damiana, O., Afuwape, O., Kayode Fasiku, O., Comensoli, O., F. Koroye O., Capener, P., Morgagni, P., Pernadas Lages, Pm., Wilkerson, Pm., Turner, P., Dutton, P., Hayes, P., Vorwald, P., Singh, P., Gan, Q., Kottayasamy Seenivasagam, R., Ayloor Seshadri, R., Guevara Castro, R., Douglas, R., Koshy, Rm., Yıldırım, R., Skipworth, Rje., Gould, Ra., Wetherill, Rc., Shaw, R., Burley, Ra., Palatucci, R., Racalbuto, R., Correia Casaca, Rm., Lagarde, Sm., Gana, S., Marietti, S., Qureshi, S., Morales-Conde, S., Molfino, S., Barreto, Sg., Turkyilmaz, S., Turan-Trabzon, S., Frisch, S., Castoldi, S., Belloni, S., Flisi, S., Galloway, S., Maria, Sr., Royston, S., Boyle, T., Sezer, T., Mengardo, V., Concepcion Martın, V., Lee Wills, V., Owen-Holt, V., Casagrande, V., Al-Khyatt, W., Jansen, W., Wang, W., Eshuis, W., Polkowski, Wp., Huang, X., Wang, X., Chen, Xz., Gonzalez Dominguez, Y., Wang, Y., Viswanath, Yks., He, Yl., Demir, Z., Na, Z., Surgery, CCA - Cancer Treatment and Quality of Life, CCA - Cancer biology and immunology, AGEM - Amsterdam Gastroenterology Endocrinology Metabolism, CCA - Imaging and biomarkers, Experimental Immunology, Clinical Immunology and Rheumatology, CCA -Cancer Center Amsterdam, and CCA - Cancer Treatment and quality of life

Subjects
medicine.medical_specialty, Manchester Cancer Research Centre, business.industry, gastric cancer, ResearchInstitutes_Networks_Beacons/mcrc, Delphi method, MEDLINE, Cancer, medicine.disease, Outcome (game theory), 03 medical and health sciences, 0302 clinical medicine, Quality of life (healthcare), 030220 oncology & carcinogenesis, Family medicine, gastros, Medicine, Surgery, 030212 general & internal medicine, Stage (cooking), Adverse effect, business, Set (psychology)
Abstract

Background Surgery is the primary treatment that can offer potential cure for gastric cancer, but is associated with significant risks. Identifying optimal surgical approaches should be based on comparing outcomes from well designed trials. Currently, trials report different outcomes, making synthesis of evidence difficult. To address this, the aim of this study was to develop a core outcome set (COS)—a standardized group of outcomes important to key international stakeholders—that should be reported by future trials in this field. Methods Stage 1 of the study involved identifying potentially important outcomes from previous trials and a series of patient interviews. Stage 2 involved patients and healthcare professionals prioritizing outcomes using a multilanguage international Delphi survey that informed an international consensus meeting at which the COS was finalized. Results Some 498 outcomes were identified from previously reported trials and patient interviews, and rationalized into 56 items presented in the Delphi survey. A total of 952 patients, surgeons, and nurses enrolled in round 1 of the survey, and 662 (70 per cent) completed round 2. Following the consensus meeting, eight outcomes were included in the COS: disease-free survival, disease-specific survival, surgery-related death, recurrence, completeness of tumour removal, overall quality of life, nutritional effects, and ‘serious’ adverse events. Conclusion A COS for surgical trials in gastric cancer has been developed with international patients and healthcare professionals. This is a minimum set of outcomes that is recommended to be used in all future trials in this field to improve trial design and synthesis of evidence.

Published
2021
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35. Updates on Surgical Management of Advanced Gastric Cancer: New Evidence and Trends. Insights from the First International Course on Upper Gastrointestinal Surgery—Varese (Italy), December 2, 2011

Author

Rausei, Stefano, Dionigi, Gianlorenzo, Sano, Takeshi, Sasako, Mitsuru, Biondi, Alberto, Morgagni, Paolo, Garofalo, Alfredo, Boni, Luigi, Frattini, Francesco, D’Ugo, Domenico, Preston, Shaun, Marrelli, Daniele, Degiuli, Maurizio, Capella, Carlo, Sacco, Rosario, Ruspi, Laura, De Manzoni, Giovanni, Roviello, Franco, Pinotti, Graziella, Rovera, Francesca, Noh, Sung Hoon, Coit, Daniel, and Dionigi, Renzo

Published
2013
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39. Consequences of the COVID-19 pandemic on the diagnosis and treatment of gastric cancer in referral centers in Italy

Author

Solaini, Leonardo, Bencivenga, Maria, Rosa, Fausto, D’ignazio, Alessia, Marino, Elisabetta, Ministrini, Silvia, Sofia, Silvia, Sacco, Michele, Mura, Gianni, Rausa, Emanuele, Prizio, Marco De, Graziosi, Luigina, Degiuli, Maurizio, Tiberio, Guido Alberto Massimo, Alfieri, Sergio, Marrelli, Daniele, Morgagni, Paolo, and Ercolani, Giorgio

Abstract

Background: The coronavirus pandemic had a major impact in Italy. The Italian health system’s re-organization to face the emergency may have led to significant consequences especially in the diagnosis and treatment of malignancies. This study aimed to assess the impact of the pandemic in the diagnosis and treatment of gastric cancer in nine Gruppo Italiano RIcerca Cancro Gastrico (GIRCG) centers.Methods: All patients assessed for gastric adenocarcinoma at nine GIRCG centers between January 2019 and November 2020 were included. Patients were grouped according to the date of “patient 1’s” diagnosis in Italy: preCOVID versus COVID. Clinico-pathological and outcome differences between the two groups were analyzed.Results: A total of 632 patients were included in the analysis (205 in the COVID group). The cT4 weighted ratios were higher in 2020 from April to September, with the greatest differences in May, August and September. The cM+ weighted ratio was significantly higher in July 2020. The mean number of gastrectomies had the greatest reduction in March and May 2020 compared with 2019. The median times from diagnosis to chemotherapy, to complete diagnostic work-up or to operation were longer in 2019. The median time from the end of chemotherapy to surgery was 17 days longer in the preCOVID group.Conclusions: A greater number of advanced or metastatic cases were diagnosed after the spread of SARS-CoV-2 infection, especially after the “full lockdown” periods. During the pandemic, once gastric cancer patients were referred to one of the centers, a shorter time to complete the diagnostic work-up or to address them to the best treatment option was required.

Published
2023
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41. Which gastric cancer patients could benefit from staging laparoscopy? A GIRCG multicenter cohort study.

Author

Solaini, Leonardo, Bencivenga, Maria, D'ignazio, Alessia, Milone, Marco, Marino, Elisabetta, De Pascale, Stefano, Rosa, Fausto, Sacco, Michele, Fumagalli Romario, Uberto, Graziosi, Luigina, De Palma, Giovanni, Marrelli, Daniele, Morgagni, Paolo, and Ercolani, Giorgio

Subjects
STOMACH cancer, CANCER patients, LAPAROSCOPY, PERITONEAL cancer, COHORT analysis, INTESTINAL tumors
Abstract

This study aimed to investigate which gastric cancer patients could benefit the most from staging laparoscopy. A retrospective cohort study was carried out, including 316 (216 cM- and 100 cM+) gastric cancer patients who had undergone staging laparoscopy between 2010 and 2020 in seven GIRCG centers. A model including easily-accessible clinical, biochemical and pathological markers was constructed to predict the risk of carcinomatosis. ROC curve and decision curve analyses were used to verify its accuracy and net benefit. In the cM-population staging laparoscopy could detect 67 cases who had peritoneal carcinomatosis or positive cytology, for a yield of 30.5%. In cM-patients, intestinal type tumors (0.25, 0.12–0.51; p = 0.002), cT4 tumors (2.18, 1.11–4.28; p = 0.023) and cancers of the lower third (0.31, 0.14–0.70; p = 0.004) were associated with the presence of peritoneal carcinomatosis and/or positive cytology. The ROC curve analysis of the model including the three variables showed an AUC of 0.75 (0.68–0.81, p < 0.001). The decision curve analyses showed that the model had a higher net benefit than the treating all strategy between threshold probabilities of 15 and 50%. Staging laparoscopy is a useful tool to address the patient with gastric cancer to the most adequate treatment. In cM-patients the assessment of the location of the tumor, the Lauren's histotype and the cT status may help in providing additional elements in indicating or not the use of staging laparoscopy. [ABSTRACT FROM AUTHOR]

Published
2022
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47. Virtual reality study of the effects of railway crossing safety technologies on pedestrian behaviour

Author

Aupetit, Samuel, Escaich, Sara, Gillet, Camille, Herber, Philippe, Grison, Elise, and Morgagni, Simone

Abstract

This study reports on the description of an evaluation of safety systems at Pedestrian Track Crossings (PTC) in French train stations installed to cross over tracks when no other installation is deployed. Two complementary systems - a physical chicane positioned before the crossing zone and a ringing alarm - have been proposed in addition to the existing flashing pictogram. A study, combining a quantitative experimental setup using virtual reality to measure the efficacy of the systems, and a qualitative ergonomic analysis method to complete the results, was proposed to 100 participants. Our results allow us to measure the effect of safety systems on participants’ crossing behaviour, gaze, and kinematic. It appears that the combination with the ringing alarm led to more safety behaviours. Moreover, qualitative data gave new perspectives to improve the system tested and make PTC safer.

Published
2023
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