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510 results on '"Mori, Tatsuo"'

1. Infantile Epileptic Spasms Syndrome Complicated by Leigh Syndrome and Leigh-Like Syndrome: A Retrospective, Nationwide, Multicenter Case Series

Author

Sasaki, Michiru, Okanishi, Tohru, Matsuoka, Tsuyoshi, Yoshimura, Ayumi, Maruyama, Shinsuke, Shiohama, Tadashi, Hoshino, Hiroki, Mori, Tatsuo, Majima, Hisakazu, Matsumoto, Hiroshi, Kobayashi, Satoru, Chiyonobu, Tomohiro, Matsushige, Takeshi, Nakamura, Kazuyuki, Kubota, Kazuo, Tanaka, Ryuta, Fujita, Takako, Enoki, Hideo, Suzuki, Yasuhiro, Nakamura, Sadao, Fujimoto, Ayataka, and Maegaki, Yoshihiro

Published
2024
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2. Clinical characteristics of SARS-CoV-2-associated encephalopathy in children: Nationwide epidemiological study

Author

Akamine, Satoshi, Chong, Pin Fee, Ema, Tatsuya, Enomoto, Sayaka, Fukatsu, Ryohei, Hanaoka, Yoshiyuki, Igarashi, Ayuko, Ikeda, Tae, Ishida, Kouhei, Ishikawa, Nobutsune, Itamura, Shinji, Iwayama, Hideyuki, Kawata, Nanako, Kawano, Go, Kikuchi, Kenjiro, Kobayashi, Osamu, Kondo, Hidehito, Korematsu, Seigo, Matsuoka, Tsuyoshi, Minamisawa, Yuki, Mitani, Osamu, Mizuma, Kanako, Mori, Tatsuo, Morichi, Shinichiro, Moriyama, Yoko, Motobayashi, Mitsuo, Motoi, Hirotaka, Muramatsu, Kazuhiro, Nakamura, Kazuyuki, Nakazawa, Tomoyuki, Negishi, Yutaka, Nishizawa, Yuka, Okada, Hiroshi, Okanari, Kazuo, Oki, Keisuke, Okumura, Yoshinori, Omata, Taku, Saeki, Saki, Sano, Fumikazu, Sano, Kentaro, Sato, Tatsuharu, Shiihara, Takashi, Shimoda, Konomi, Suzuki, Motomasa, Tanaka, Ryuta, Tokorodani, Chiho, Uematsu, Mitsugu, Yamada, Hiroyuki, Yamamoto, Naohiro, Yamamoto, Tatsuya, Yokoyama, Haruna, Kasai, Mariko, Sakuma, Hiroshi, Abe, Yuichi, Kuki, Ichiro, Maegaki, Yoshihiro, Murayama, Kei, Murofushi, Yuka, Nagase, Hiroaki, Nishiyama, Masahiro, Okumura, Akihisa, Sakai, Yasunari, Tada, Hiroko, Mizuguchi, Masashi, and Takanashi, Jun-ichi

Published
2024
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7. Clinical characteristics of SARS-CoV-2-associated encephalopathy in children: Nationwide epidemiological study

Author

Kasai, Mariko, primary, Sakuma, Hiroshi, additional, Abe, Yuichi, additional, Kuki, Ichiro, additional, Maegaki, Yoshihiro, additional, Murayama, Kei, additional, Murofushi, Yuka, additional, Nagase, Hiroaki, additional, Nishiyama, Masahiro, additional, Okumura, Akihisa, additional, Sakai, Yasunari, additional, Tada, Hiroko, additional, Mizuguchi, Masashi, additional, Takanashi, Jun-ichi, additional, Akamine, Satoshi, additional, Chong, Pin Fee, additional, Ema, Tatsuya, additional, Enomoto, Sayaka, additional, Fukatsu, Ryohei, additional, Hanaoka, Yoshiyuki, additional, Igarashi, Ayuko, additional, Ikeda, Tae, additional, Ishida, Kouhei, additional, Ishikawa, Nobutsune, additional, Itamura, Shinji, additional, Iwayama, Hideyuki, additional, Kawata, Nanako, additional, Kawano, Go, additional, Kikuchi, Kenjiro, additional, Kobayashi, Osamu, additional, Kondo, Hidehito, additional, Korematsu, Seigo, additional, Matsuoka, Tsuyoshi, additional, Minamisawa, Yuki, additional, Mitani, Osamu, additional, Mizuma, Kanako, additional, Mori, Tatsuo, additional, Morichi, Shinichiro, additional, Moriyama, Yoko, additional, Motobayashi, Mitsuo, additional, Motoi, Hirotaka, additional, Muramatsu, Kazuhiro, additional, Nakamura, Kazuyuki, additional, Nakazawa, Tomoyuki, additional, Negishi, Yutaka, additional, Nishizawa, Yuka, additional, Okada, Hiroshi, additional, Okanari, Kazuo, additional, Oki, Keisuke, additional, Okumura, Yoshinori, additional, Omata, Taku, additional, Saeki, Saki, additional, Sano, Fumikazu, additional, Sano, Kentaro, additional, Sato, Tatsuharu, additional, Shiihara, Takashi, additional, Shimoda, Konomi, additional, Suzuki, Motomasa, additional, Tanaka, Ryuta, additional, Tokorodani, Chiho, additional, Uematsu, Mitsugu, additional, Yamada, Hiroyuki, additional, Yamamoto, Naohiro, additional, Yamamoto, Tatsuya, additional, and Yokoyama, Haruna, additional

Published
2024
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13. A case of epilepsy with myoclonic atonic seizures caused by SLC6A1 gene mutation due to balanced chromosomal translocation

Author

Mori, Tatsuo, Sakamoto, Masamune, Tayama, Takahiro, Goji, Aya, Toda, Yoshihiro, Fujita, Atsushi, Mizuguchi, Takeshi, Urushihara, Maki, Matsumoto, Naomichi, Mori, Tatsuo, Sakamoto, Masamune, Tayama, Takahiro, Goji, Aya, Toda, Yoshihiro, Fujita, Atsushi, Mizuguchi, Takeshi, Urushihara, Maki, and Matsumoto, Naomichi

Abstract

Introduction Epilepsy with myoclonic atonic seizures (EMAtS) was previously thought to occur in normally developing children. We report a female case of EMAtS and mild developmental delay before onset. Importantly, a de novo balanced chromosomal translocation was recognized in the patient. Case presentation The patient was a 4-year-old girl. Mild developmental delay was observed during infancy. At the age of one and a half years, she developed atonic seizures once a month. At 4 years of age, her seizures increased to more than 10 times per hour. An ictal electroencephalogram (EEG) showed a 3–4-Hz spike-and-wave complex, which was consistent with atonic and myoclonic seizures of the trunk, eyelids, and lips. Therefore, EMAtS was diagnosed based on the symptoms and EEG findings. After administration of valproic acid (VPA), the epileptic seizures disappeared immediately. At the age of 5 years and 2 months, the seizures recurred but disappeared again when the dose of VPA was increased. Subsequently, no recurrence was observed until 6 years and 3 months of age on VPA and lamotrigine. Chromosome analysis of the patient disclosed 46,XX,t(3;11)(p25;q13.1)dn. Long-read sequencing of the the patient’s genomic DNA revealed that the 3p25.3 translocation breakpoint disrupted the intron 7 of the SLC6A1 gene. Conclusion The SLC6A1 disruption by chromosome translocation well explains the clinical features of this patient. Long-read sequencing is a powerful technique to determine genomic abnormality at the nucleotide level for disease-associated chromosomal abnormality.

Published
2023

18. Usefulness of Near-Infrared Spectroscopy (NIRS) for evaluating drug effects and improvements in medication adherence in children with Attention Deficit Hyperactivity Disorder (ADHD)

Author

Kawai, Chihiro, Mori, Kenji, Tanioka, Tetsuya, Betriana, Feni, Mori, Keiko, Mori, Tatsuo, and Ito, Hiromichi

Subjects
mental disorders, medication adherence, ADHD (attention deficit hyperactivity disorder), frontal lobe function, behavioral disciplines and activities, Children, NIRS (near-infrared spectroscopy)
Abstract

The symptoms of attention deficit hyperactivity disorder (ADHD) are inattention, hyperactivity, and impulsiveness. Physicians often prescribe methylphenidate (MPH) for children with ADHD for long periods of time. The purpose of the present study was to investigate the usefulness of near-infrared spectroscopy (NIRS) for evaluating drug effects and improvements in medication adherence in children with ADHD. Subjects were 10 male children diagnosed with ADHD : average age, 9.3 years, and 10 boys with typical development : average age 9.5 years. Children with intellectual disability, autism, and obvious depressive symptoms were excluded. The present study revealed that in the ADHD group, oxy-Hb concentrations in the left and right lateral prefrontal cortex significantly increased during the execution of the Stroop color-word test in both channels when taking MPH. This method was considered to be useful for assessing drug effects on ADHD because NIRS is an objective indicator for evaluating ADHD executive dysfunction and visualizes the activation of frontal lobe function by MPH. A pediatric neurologist explained the results of NIRS while presenting images to the ADHD group, and medication adherence and the drug-taking ratio both markedly improved. Therefore, this therapeutic explanation is an effective strategy for improving medication compliance and adherence among patients.

Published
2021

19. ARID1B deletion in intractable epilepsy

Author

Mori, Tatsuo, Goji, Aya, Toda, Yoshihiro, Ito, Hiromichi, Kawarai, Toshitaka, Fujita, Atsushi, Matsumoto, Naomichi, and Mori, Kenji

Subjects
Epilepsy, Coffin-Siris syndrome, ARID1B, sodium valproate, partial gene deletion
Abstract

Although epilepsy is a known complication in Coffin-Siris syndrome, its clinical symptoms and effective treatment methods have not been thoroughly investigated so far. Here, we present the case of a female with a 594-kb interstitial deletion at 6q25.3, involving partially ARID1B, with developmental delay, short stature, and intractable epilepsy. At 4 years of age, she developed epilepsy with clonic seizures in the right half of her body. Treatment with carbamazepine, levetiracetam, or topiramate was ineffective. The frequency of epileptic seizures gradually worsened. At the peak of her seizures, she had focal onset clonic seizures 3-4 times a month, and neck atonic seizures lasting for several seconds more than 10 times a day. After administration of sodium valproate, her epileptic seizures decreased to 0-1 times a year. In conclusion, gathering genetic information in Coffin-Siris syndrome allows improvement of epilepsy treatment and outcomes in these patients.

Published
2021

32. Red-color-modulated perovskite solar cells with copper(I) thiocyanate/cellulose acetate-based distributed Bragg reflectors

Author

Seike, Yoshiyuki, Isogawa, Yuya, Goshima, Keishiro, Ichino, Yusuke, Taoka, Noriyuki, and Mori, Tatsuo

Abstract

This study investigates the development of perovskite solar cells (PSCs) equipped with distributed Bragg reflectors (DBRs) through a coating-based fabrication technique. The incorporation of DBRs enhanced the esthetic appeal and improved the light absorption properties of PSCs, rendering them suitable for building-integrated photovoltaics (BIPV). The DBRs, composed of 3–11 layers of copper(I) thiocyanate and cellulose acetate, exhibited peak reflectance at 700 nm. However, as the number of DBR layers increased, there was a corresponding decrease in short-circuit current density (Jsc) and power conversion efficiency (PCE) due to greater light reflection. Specifically, compared with PSCs without DBRs, those with 11-layer DBRs showed 41.2% and 39.0% reduction in Jscand PCE, respectively. Despite these reductions, this study highlights the potential of colored PSCs for practical BIPV applications, achieving a balance between esthetics and efficiency.

Published
2024
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33. A partial ARID1B deletion in a female child with intractable epilepsy

Author

Mori, Tatsuo, Goji, Aya, Toda, Yoshihiro, Ito, Hiromichi, Kawarai, Toshitaka, Fujita, Atsushi, Matsumoto, Naomichi, Mori, Kenji, Mori, Tatsuo, Goji, Aya, Toda, Yoshihiro, Ito, Hiromichi, Kawarai, Toshitaka, Fujita, Atsushi, Matsumoto, Naomichi, and Mori, Kenji

Abstract

Although epilepsy is a known complication in Coffin-Siris syndrome, its clinical symptoms and effective treatment methods have not been thoroughly investigated so far. Here, we present the case of a female with a 594-kb interstitial deletion at 6q25.3, involving partially ARID1B, with developmental delay, short stature, and intractable epilepsy. At 4 years of age, she developed epilepsy with clonic seizures in the right half of her body. Treatment with carbamazepine, levetiracetam, or topiramate was ineffective. The frequency of epileptic seizures gradually worsened. At the peak of her seizures, she had focal onset clonic seizures 3-4 times a month, and neck atonic seizures lasting for several seconds more than 10 times a day. After administration of sodium valproate, her epileptic seizures decreased to 0-1 times a year. In conclusion, gathering genetic information in Coffin-Siris syndrome allows improvement of epilepsy treatment and outcomes in these patients.

Published
2021

34. Effects of manufacturing technology on electrical breakdown and morphology of thin films of low density polyethylene blended with polypropylene copolymer

Author

Zhang, Chao, Mori, Tatsuo, Mizutani, Teruyoshi, and Ishioka, Mitsugu

Subjects
Polypropylene -- Analysis, Business, Electronics, Electronics and electrical industries
Abstract

Extruded films prepared from blends of low-density polyethylene (LDPE) and random copolymer of ethylene and propylene (EP) with the T-die method were studied with respect to electrical properties and morphology. Comparisons with data on blown films are made. These blends are of interest as improved LDPE for making XLPE for insulated power cable. In the high temperature region (90[degrees]C), a specimen with a slightly higher EP content had higher impulse breakdown strength than that with a lower EP content, but no improvement of dc breakdown strength by blending could be found. The improvement of impulse breakdown strength (90[degrees]C) is explained in terms of morphological changes by blending such as the orientation of chains in a film and the size of spherulites on the assumption of the thermal breakdown. In comparison, a T-die film had higher impulse breakdown strength than that of a blown film for the same composition. The impulse breakdown strength also increased with the use of the higher density LDPE. In the current versus electric field characteristics at 30[degrees]C, the blend polymer with EP content of 5-10% showed a transition from LDPE behavior at low field region to EP behavior at high field region. However, no appreciable difference in current behavior among the specimens was observed at 90[degrees]C, which suggests an incompatibility between the two materials that exists at 30[degrees]C but not at 90[degrees]C. Index Terms--Low density polyethylene, polypropylene, copolymer, blends, electrical breakdown, morphology, thin films.

Published
2003

43. Survey of patients with spinal muscular atrophy on the island of Shikoku, Japan

Author

Okamoto, Kentaro, primary, Motoki, Takahiro, additional, Saito, Isao, additional, Urate, Risako, additional, Aibara, Kaori, additional, Jogamoto, Toshihiro, additional, Fukuda, Mitsumasa, additional, Wakamoto, Hiroyuki, additional, Maniwa, Satoshi, additional, Kondo, Yoichi, additional, Toda, Yoshihiro, additional, Goji, Aya, additional, Mori, Tatsuo, additional, Soga, Tomohiro, additional, Konishi, Yukihiko, additional, Nagai, Shigehiro, additional, Takami, Yoko, additional, Tokorodani, Chiho, additional, Nishiuchi, Ritsuo, additional, Usui, Daisuke, additional, Ando, Rina, additional, Tada, Satoshi, additional, Yamanishi, Yuki, additional, Nagai, Masahiro, additional, Arakawa, Reiko, additional, Saito, Kayoko, additional, Nishio, Hisahide, additional, Ishii, Eiichi, additional, and Eguchi, Mariko, additional

Published
2020
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44. Association of Dermatomyositis Sine Dermatitis With Anti–Nuclear Matrix Protein 2 Autoantibodies

Author

Inoue, Michio, primary, Tanboon, Jantima, additional, Hirakawa, Shinya, additional, Komaki, Hirofumi, additional, Fukushima, Takeshi, additional, Awano, Hiroyuki, additional, Tajima, Takashi, additional, Yamazaki, Kenji, additional, Hayashi, Ryutaro, additional, Mori, Tatsuo, additional, Shibuya, Kazumoto, additional, Yamanoi, Takahiko, additional, Yoshimura, Hajime, additional, Ogawa, Tomohiro, additional, Katayama, Atsushi, additional, Sugai, Fuminobu, additional, Nakayama, Yoichi, additional, Yamaguchi, Satoko, additional, Hayashi, Shinichiro, additional, Noguchi, Satoru, additional, Tachimori, Hisateru, additional, Okiyama, Naoko, additional, Fujimoto, Manabu, additional, and Nishino, Ichizo, additional

Published
2020
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50. Multi-delay arterial spin labeling brain magnetic resonance imaging study for pediatric autism

Author

Mori, Tatsuo, Ito, Hiromichi, Harada, Masafumi, Hisaoka, Sonoka, Matsumoto, Yuki, Goji, Aya, Toda, Yoshihiro, Mori, Kenji, Kagami, Shoji, Mori, Tatsuo, Ito, Hiromichi, Harada, Masafumi, Hisaoka, Sonoka, Matsumoto, Yuki, Goji, Aya, Toda, Yoshihiro, Mori, Kenji, and Kagami, Shoji

Abstract

Introduction Arterial spin labeling (ASL) is a non-invasive magnetic resonance imaging (MRI) technique that can measure regional cerebral blood flow (rCBF) without radiation exposure. This study aimed to evaluate rCBF in individuals with autism and their age-matched controls, globally and regionally. Methods We performed ASL MRI (3T, pulsed-continuous ASL, 3 delayed ASL imaging sequences) for 33 patients with autism spectrum disorder (ASD) (average age: 7.3 years, range: 2-14 years). Nineteen children (average age: 8.6 years, range: 3-15 years) without ASD and intellectual delay were included as controls. Patients with morphological abnormalities detected on MRI were excluded. Objective analysis was performed with automatic region of interest analysis of the ASL results. The Mann-Whitney U test was used to compare the rCBF results between the groups. Results Compared to the controls, patients with ASD showed a statistically significant decrease in rCBF, respectively, in the insula [left, rCBF 51.8±9.5 mL/100 g/min (mean±SD) versus 59.9±9.8, p=0.0017; right, 51.2±10.1 versus 57.8±8.8, p=0.0354], superior parietal lobule (left, 44.6±8.4 versus 52.0±7.8, p=0.003), superior temporal gyrus (left, 50.0±8.6 versus 56.9±8.6, p=0.007; right, 49.5±8.4 versus 56.4±7.7, p=0.0058), and inferior frontal gyrus (left, 53.0±9.8 versus 59.3±9.9, p=0.0279), which are associated with the mirror neuron system. Conclusions We concluded that patients with ASD showed a statistically significant decline in CBF in regions associated with the mirror neuron system. The advantages of ASL MRI include low invasiveness (no radiation exposure) and short imaging time (approximately 5 min). Studies with larger sample sizes are required to establish the diagnostic value of ASL MRI for ASD.

Published
2020

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