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15. Initial results with [18F]FAPI-74 PET/CT in idiopathic pulmonary fibrosis.

Author

Mori, Yuriko, Kramer, Vasko, Novruzov, Emil, Mamlins, Eduards, Röhrich, Manuel, Fernández, René, Amaral, Horacio, Soza-Ried, Cristian, Monje, Barbara, Sabbagh, Eduardo, Florenzano, Matías, Giesel, Frederik L., and Undurraga, Álvaro

Subjects
*IDIOPATHIC pulmonary fibrosis, *INTERSTITIAL lung diseases, *POSITRON emission tomography, *LUNG diseases, *PULMONARY fibrosis, *VITAL capacity (Respiration)
Abstract

Idiopathic pulmonary fibrosis (IPF) is a chronic fibrosing interstitial lung disease with a poor prognosis. 68Ga-labeled FAP ligands exhibited highly promising results due to the crucial role of activated fibroblasts in fibrosis imaging of the lung. However, 18F-labeled FAP ligands might provide qualitatively much higher imaging results with accompanying economic benefits due to large-scale production. Thus, we sought to investigate the potential of [18F]FAPI-74 prospectively in a small patient cohort. Methods: Eight patients underwent both [18F]FAPI-74-PET/CT and HRCT scans and were then compared with a control group without any fibrosing pulmonary disease. The tracer uptake of fibrotic lung areas was analyzed in synopsis with radiological and clinical parameters. Results: We observed a positive correlation between the fibrotic active volume, the Hounsfield scale, as well as the vital and diffusing capacity of the lung. Conclusion: The initial results confirm our assumption that [18F]FAPI-74 offers a viable non-invasive assessment method for pulmonary fibrotic changes in patients with IPF. [ABSTRACT FROM AUTHOR]

Published
2024
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17. Epithelioid granuloma mimicking lung cancer showed intense uptake on [18F]FAPI-74 PET

Author

Watabe, Tadashi, primary, David, Ivan Ray, additional, Kimura, Toru, additional, Hiroshima, Takashi, additional, Tatsumi, Mitsuaki, additional, Naka, Sadahiro, additional, Kamiya, Takashi, additional, Fukui, Eriko, additional, Kanou, Takashi, additional, Ose, Naoko, additional, Funaki, Soichiro, additional, Mori, Yuriko, additional, Cardinale, Jens, additional, Kato, Hiroki, additional, Morii, Eiichi, additional, Shintani, Yasushi, additional, and Giesel, Frederik L., additional

Published
2023
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19. Initial Results with [18F]FAPI-74 PET/CT in Idiopathic Pulmonary Fibrosis

Author

Mori, Yuriko, primary, Kramer, Vasko, additional, Novruzov, Emil, additional, Mamlins, Eduards, additional, Röhrich, Manuel, additional, Fernández, René, additional, Amaral, Horacio, additional, Soza-Ried, Cristian, additional, Monje, Barbara, additional, Sabbagh, Eduardo, additional, Florenzano, Matías, additional, Giesel, Frederik L., additional, and Undurraga, Álvaro, additional

Published
2023
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20. Initial Evaluation of [18F]FAPI-74 PET for Various Histopathologically Confirmed Cancers and Benign Lesions

Author

Watabe, Tadashi, primary, Naka, Sadahiro, additional, Tatsumi, Mitsuaki, additional, Kamiya, Takashi, additional, Kimura, Toru, additional, Shintani, Yasushi, additional, Abe, Kaori, additional, Miyake, Tomohiro, additional, Shimazu, Kenzo, additional, Kobayashi, Shogo, additional, Kurokawa, Yukinori, additional, Eguchi, Hidetoshi, additional, Doki, Yuichiro, additional, Inohara, Hidenori, additional, Kato, Hiroki, additional, Mori, Yuriko, additional, Cardinale, Jens, additional, and Giesel, Frederik L., additional

Published
2023
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21. Head-to-Head Intra-Individual Comparison of Biodistribution and Tumor Uptake of [18F]FAPI-74 with [18F]FDG in Patients with PDAC: A Prospective Exploratory Study

Author

Novruzov, Emil, primary, Giesel, Frederik L., additional, Mori, Yuriko, additional, Choyke, Peter L., additional, Dabir, Mardjan, additional, Mamlins, Eduards, additional, Schmitt, Dominik, additional, Antke, Christina, additional, Pinto, Claudio, additional, Soza-Ried, Cristian, additional, Fernandez, Rene, additional, Amaral, Horacio, additional, Kramer, Vasko, additional, and Badinez, Leonardo, additional

Published
2023
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22. Intra-Individual Comparison of Physiologic [68Ga]Ga-PSMA-11 and [18F]PSMA-1007 Uptake in Ganglia in Patients with Prostate Cancer: A Retrospective, Monocentric Analysis

Author

Novruzov, Emil, primary, Schmitt, Dominik, additional, Mattes-György, Katalin, additional, Beu, Markus, additional, Mori, Yuriko, additional, Dabir, Mardjan, additional, Radtke, Jan Philipp, additional, Niegisch, Günter, additional, Albers, Peter, additional, Schimmöller, Lars, additional, Antoch, Gerald, additional, Antke, Christina, additional, Giesel, Frederik L., additional, and Mamlins, Eduards, additional

Published
2023
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24. Supplementary Table S1 from Hypermethylation of Tachykinin-1 Is a Potential Biomarker in Human Esophageal Cancer

Author

Jin, Zhe, primary, Olaru, Alexandru, primary, Yang, Jian, primary, Sato, Fumiaki, primary, Cheng, Yulan, primary, Kan, Takatsugu, primary, Mori, Yuriko, primary, Mantzur, Carmit, primary, Paun, Bogdan, primary, Hamilton, James P., primary, Ito, Tetsuo, primary, Wang, Suna, primary, David, Stefan, primary, Agarwal, Rachana, primary, Beer, David G., primary, Abraham, John M., primary, and Meltzer, Stephen J., primary

Published
2023
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25. Supplementary Tables S1 & S2 from Reprimo Methylation Is a Potential Biomarker of Barrett's-Associated Esophageal Neoplastic Progression

Author

Hamilton, James P., primary, Sato, Fumiaki, primary, Jin, Zhe, primary, Greenwald, Bruce D., primary, Ito, Tetsuo, primary, Mori, Yuriko, primary, Paun, Bogdan C., primary, Kan, Takatsugu, primary, Cheng, Yulan, primary, Wang, Suna, primary, Yang, Jian, primary, Abraham, John M., primary, and Meltzer, Stephen J., primary

Published
2023
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26. Supplementary Figure S1 from Reprimo Methylation Is a Potential Biomarker of Barrett's-Associated Esophageal Neoplastic Progression

Author

Hamilton, James P., primary, Sato, Fumiaki, primary, Jin, Zhe, primary, Greenwald, Bruce D., primary, Ito, Tetsuo, primary, Mori, Yuriko, primary, Paun, Bogdan C., primary, Kan, Takatsugu, primary, Cheng, Yulan, primary, Wang, Suna, primary, Yang, Jian, primary, Abraham, John M., primary, and Meltzer, Stephen J., primary

Published
2023
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27. Supplementary Table 1 from A Multicenter, Double-Blinded Validation Study of Methylation Biomarkers for Progression Prediction in Barrett's Esophagus

Author

Jin, Zhe, primary, Cheng, Yulan, primary, Gu, Wen, primary, Zheng, Yingye, primary, Sato, Fumiaki, primary, Mori, Yuriko, primary, Olaru, Alexandru V., primary, Paun, Bogdan C., primary, Yang, Jian, primary, Kan, Takatsugu, primary, Ito, Tetsuo, primary, Hamilton, James P., primary, Selaru, Florin M., primary, Agarwal, Rachana, primary, David, Stefan, primary, Abraham, John M., primary, Wolfsen, Herbert C., primary, Wallace, Michael B., primary, Shaheen, Nicholas J., primary, Washington, Kay, primary, Wang, Jean, primary, Canto, Marcia Irene, primary, Bhattacharyya, Achyut, primary, Nelson, Mark A., primary, Wagner, Paul D., primary, Romero, Yvonne, primary, Wang, Kenneth K., primary, Feng, Ziding, primary, Sampliner, Richard E., primary, and Meltzer, Stephen J., primary

Published
2023
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28. Supplementary Table 1 from Activin Type II Receptor Restoration in ACVR2-Deficient Colon Cancer Cells Induces Transforming Growth Factor-β Response Pathway Genes

Author

Deacu, Elena, primary, Mori, Yuriko, primary, Sato, Fumiaki, primary, Yin, Jing, primary, Olaru, Andreea, primary, Sterian, Anca, primary, Xu, Yan, primary, Wang, Suna, primary, Schulmann, Karsten, primary, Berki, Agnes, primary, Kan, Takatsugu, primary, Abraham, John M., primary, and Meltzer, Stephen J., primary

Published
2023
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29. Supplementary Figure 1 Legend from Activin Type II Receptor Restoration in ACVR2-Deficient Colon Cancer Cells Induces Transforming Growth Factor-β Response Pathway Genes

Author

Deacu, Elena, primary, Mori, Yuriko, primary, Sato, Fumiaki, primary, Yin, Jing, primary, Olaru, Andreea, primary, Sterian, Anca, primary, Xu, Yan, primary, Wang, Suna, primary, Schulmann, Karsten, primary, Berki, Agnes, primary, Kan, Takatsugu, primary, Abraham, John M., primary, and Meltzer, Stephen J., primary

Published
2023
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30. Supplementary Table 3 from A Multicenter, Double-Blinded Validation Study of Methylation Biomarkers for Progression Prediction in Barrett's Esophagus

Author

Jin, Zhe, primary, Cheng, Yulan, primary, Gu, Wen, primary, Zheng, Yingye, primary, Sato, Fumiaki, primary, Mori, Yuriko, primary, Olaru, Alexandru V., primary, Paun, Bogdan C., primary, Yang, Jian, primary, Kan, Takatsugu, primary, Ito, Tetsuo, primary, Hamilton, James P., primary, Selaru, Florin M., primary, Agarwal, Rachana, primary, David, Stefan, primary, Abraham, John M., primary, Wolfsen, Herbert C., primary, Wallace, Michael B., primary, Shaheen, Nicholas J., primary, Washington, Kay, primary, Wang, Jean, primary, Canto, Marcia Irene, primary, Bhattacharyya, Achyut, primary, Nelson, Mark A., primary, Wagner, Paul D., primary, Romero, Yvonne, primary, Wang, Kenneth K., primary, Feng, Ziding, primary, Sampliner, Richard E., primary, and Meltzer, Stephen J., primary

Published
2023
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31. Data from Activin Type II Receptor Restoration in ACVR2-Deficient Colon Cancer Cells Induces Transforming Growth Factor-β Response Pathway Genes

Author

Deacu, Elena, primary, Mori, Yuriko, primary, Sato, Fumiaki, primary, Yin, Jing, primary, Olaru, Andreea, primary, Sterian, Anca, primary, Xu, Yan, primary, Wang, Suna, primary, Schulmann, Karsten, primary, Berki, Agnes, primary, Kan, Takatsugu, primary, Abraham, John M., primary, and Meltzer, Stephen J., primary

Published
2023
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32. Supplementary Figure 2 from A Multicenter, Double-Blinded Validation Study of Methylation Biomarkers for Progression Prediction in Barrett's Esophagus

Author

Jin, Zhe, primary, Cheng, Yulan, primary, Gu, Wen, primary, Zheng, Yingye, primary, Sato, Fumiaki, primary, Mori, Yuriko, primary, Olaru, Alexandru V., primary, Paun, Bogdan C., primary, Yang, Jian, primary, Kan, Takatsugu, primary, Ito, Tetsuo, primary, Hamilton, James P., primary, Selaru, Florin M., primary, Agarwal, Rachana, primary, David, Stefan, primary, Abraham, John M., primary, Wolfsen, Herbert C., primary, Wallace, Michael B., primary, Shaheen, Nicholas J., primary, Washington, Kay, primary, Wang, Jean, primary, Canto, Marcia Irene, primary, Bhattacharyya, Achyut, primary, Nelson, Mark A., primary, Wagner, Paul D., primary, Romero, Yvonne, primary, Wang, Kenneth K., primary, Feng, Ziding, primary, Sampliner, Richard E., primary, and Meltzer, Stephen J., primary

Published
2023
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33. Supplementary Figure Legends 1-2 from A Multicenter, Double-Blinded Validation Study of Methylation Biomarkers for Progression Prediction in Barrett's Esophagus

Author

Jin, Zhe, primary, Cheng, Yulan, primary, Gu, Wen, primary, Zheng, Yingye, primary, Sato, Fumiaki, primary, Mori, Yuriko, primary, Olaru, Alexandru V., primary, Paun, Bogdan C., primary, Yang, Jian, primary, Kan, Takatsugu, primary, Ito, Tetsuo, primary, Hamilton, James P., primary, Selaru, Florin M., primary, Agarwal, Rachana, primary, David, Stefan, primary, Abraham, John M., primary, Wolfsen, Herbert C., primary, Wallace, Michael B., primary, Shaheen, Nicholas J., primary, Washington, Kay, primary, Wang, Jean, primary, Canto, Marcia Irene, primary, Bhattacharyya, Achyut, primary, Nelson, Mark A., primary, Wagner, Paul D., primary, Romero, Yvonne, primary, Wang, Kenneth K., primary, Feng, Ziding, primary, Sampliner, Richard E., primary, and Meltzer, Stephen J., primary

Published
2023
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34. Supplementary Table 2 from A Multicenter, Double-Blinded Validation Study of Methylation Biomarkers for Progression Prediction in Barrett's Esophagus

Author

Jin, Zhe, primary, Cheng, Yulan, primary, Gu, Wen, primary, Zheng, Yingye, primary, Sato, Fumiaki, primary, Mori, Yuriko, primary, Olaru, Alexandru V., primary, Paun, Bogdan C., primary, Yang, Jian, primary, Kan, Takatsugu, primary, Ito, Tetsuo, primary, Hamilton, James P., primary, Selaru, Florin M., primary, Agarwal, Rachana, primary, David, Stefan, primary, Abraham, John M., primary, Wolfsen, Herbert C., primary, Wallace, Michael B., primary, Shaheen, Nicholas J., primary, Washington, Kay, primary, Wang, Jean, primary, Canto, Marcia Irene, primary, Bhattacharyya, Achyut, primary, Nelson, Mark A., primary, Wagner, Paul D., primary, Romero, Yvonne, primary, Wang, Kenneth K., primary, Feng, Ziding, primary, Sampliner, Richard E., primary, and Meltzer, Stephen J., primary

Published
2023
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35. Supplementary Methods section from Identification of Genes Uniquely Involved in Frequent Microsatellite Instability Colon Carcinogenesis by Expression Profiling Combined with Epigenetic Scanning

Author

Mori, Yuriko, primary, Yin, Jing, primary, Sato, Fumiaki, primary, Sterian, Anca, primary, Simms, Lisa A., primary, Selaru, Florin M., primary, Schulmann, Karsten, primary, Xu, Yan, primary, Olaru, Andreea, primary, Wang, Suna, primary, Deacu, Elena, primary, Abraham, John M., primary, Young, Joanne, primary, Leggett, Barbara A., primary, and Meltzer, Stephen J., primary

Published
2023
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36. Supplementary Methods from Activin Type II Receptor Restoration in ACVR2-Deficient Colon Cancer Cells Induces Transforming Growth Factor-β Response Pathway Genes

Author

Deacu, Elena, primary, Mori, Yuriko, primary, Sato, Fumiaki, primary, Yin, Jing, primary, Olaru, Andreea, primary, Sterian, Anca, primary, Xu, Yan, primary, Wang, Suna, primary, Schulmann, Karsten, primary, Berki, Agnes, primary, Kan, Takatsugu, primary, Abraham, John M., primary, and Meltzer, Stephen J., primary

Published
2023
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37. Data from A Multicenter, Double-Blinded Validation Study of Methylation Biomarkers for Progression Prediction in Barrett's Esophagus

Author

Jin, Zhe, primary, Cheng, Yulan, primary, Gu, Wen, primary, Zheng, Yingye, primary, Sato, Fumiaki, primary, Mori, Yuriko, primary, Olaru, Alexandru V., primary, Paun, Bogdan C., primary, Yang, Jian, primary, Kan, Takatsugu, primary, Ito, Tetsuo, primary, Hamilton, James P., primary, Selaru, Florin M., primary, Agarwal, Rachana, primary, David, Stefan, primary, Abraham, John M., primary, Wolfsen, Herbert C., primary, Wallace, Michael B., primary, Shaheen, Nicholas J., primary, Washington, Kay, primary, Wang, Jean, primary, Canto, Marcia Irene, primary, Bhattacharyya, Achyut, primary, Nelson, Mark A., primary, Wagner, Paul D., primary, Romero, Yvonne, primary, Wang, Kenneth K., primary, Feng, Ziding, primary, Sampliner, Richard E., primary, and Meltzer, Stephen J., primary

Published
2023
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38. Data from Pituitary Tumor-Transforming 1 Increases Cell Motility and Promotes Lymph Node Metastasis in Esophageal Squamous Cell Carcinoma

Author

Ito, Tetsuo, primary, Shimada, Yutaka, primary, Kan, Takatsugu, primary, David, Stefan, primary, Cheng, Yulan, primary, Mori, Yuriko, primary, Agarwal, Rachana, primary, Paun, Bogdan, primary, Jin, Zhe, primary, Olaru, Alexandru, primary, Hamilton, James P., primary, Yang, Jian, primary, Abraham, John M., primary, Meltzer, Stephen J., primary, and Sato, Fumiaki, primary

Published
2023
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39. Supplementary Figure 1 from A Multicenter, Double-Blinded Validation Study of Methylation Biomarkers for Progression Prediction in Barrett's Esophagus

Author

Jin, Zhe, primary, Cheng, Yulan, primary, Gu, Wen, primary, Zheng, Yingye, primary, Sato, Fumiaki, primary, Mori, Yuriko, primary, Olaru, Alexandru V., primary, Paun, Bogdan C., primary, Yang, Jian, primary, Kan, Takatsugu, primary, Ito, Tetsuo, primary, Hamilton, James P., primary, Selaru, Florin M., primary, Agarwal, Rachana, primary, David, Stefan, primary, Abraham, John M., primary, Wolfsen, Herbert C., primary, Wallace, Michael B., primary, Shaheen, Nicholas J., primary, Washington, Kay, primary, Wang, Jean, primary, Canto, Marcia Irene, primary, Bhattacharyya, Achyut, primary, Nelson, Mark A., primary, Wagner, Paul D., primary, Romero, Yvonne, primary, Wang, Kenneth K., primary, Feng, Ziding, primary, Sampliner, Richard E., primary, and Meltzer, Stephen J., primary

Published
2023
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40. Supplementary Table 1 from Identification of Genes Uniquely Involved in Frequent Microsatellite Instability Colon Carcinogenesis by Expression Profiling Combined with Epigenetic Scanning

Author

Mori, Yuriko, primary, Yin, Jing, primary, Sato, Fumiaki, primary, Sterian, Anca, primary, Simms, Lisa A., primary, Selaru, Florin M., primary, Schulmann, Karsten, primary, Xu, Yan, primary, Olaru, Andreea, primary, Wang, Suna, primary, Deacu, Elena, primary, Abraham, John M., primary, Young, Joanne, primary, Leggett, Barbara A., primary, and Meltzer, Stephen J., primary

Published
2023
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41. Supplementary Table 2 from Activin Type II Receptor Restoration in ACVR2-Deficient Colon Cancer Cells Induces Transforming Growth Factor-β Response Pathway Genes

Author

Deacu, Elena, primary, Mori, Yuriko, primary, Sato, Fumiaki, primary, Yin, Jing, primary, Olaru, Andreea, primary, Sterian, Anca, primary, Xu, Yan, primary, Wang, Suna, primary, Schulmann, Karsten, primary, Berki, Agnes, primary, Kan, Takatsugu, primary, Abraham, John M., primary, and Meltzer, Stephen J., primary

Published
2023
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42. Supplementary Table 2 from Identification of Genes Uniquely Involved in Frequent Microsatellite Instability Colon Carcinogenesis by Expression Profiling Combined with Epigenetic Scanning

Author

Mori, Yuriko, primary, Yin, Jing, primary, Sato, Fumiaki, primary, Sterian, Anca, primary, Simms, Lisa A., primary, Selaru, Florin M., primary, Schulmann, Karsten, primary, Xu, Yan, primary, Olaru, Andreea, primary, Wang, Suna, primary, Deacu, Elena, primary, Abraham, John M., primary, Young, Joanne, primary, Leggett, Barbara A., primary, and Meltzer, Stephen J., primary

Published
2023
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43. Data from Identification of Genes Uniquely Involved in Frequent Microsatellite Instability Colon Carcinogenesis by Expression Profiling Combined with Epigenetic Scanning

Author

Mori, Yuriko, primary, Yin, Jing, primary, Sato, Fumiaki, primary, Sterian, Anca, primary, Simms, Lisa A., primary, Selaru, Florin M., primary, Schulmann, Karsten, primary, Xu, Yan, primary, Olaru, Andreea, primary, Wang, Suna, primary, Deacu, Elena, primary, Abraham, John M., primary, Young, Joanne, primary, Leggett, Barbara A., primary, and Meltzer, Stephen J., primary

Published
2023
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44. Supplementary Figure 1 from Activin Type II Receptor Restoration in ACVR2-Deficient Colon Cancer Cells Induces Transforming Growth Factor-β Response Pathway Genes

Author

Deacu, Elena, primary, Mori, Yuriko, primary, Sato, Fumiaki, primary, Yin, Jing, primary, Olaru, Andreea, primary, Sterian, Anca, primary, Xu, Yan, primary, Wang, Suna, primary, Schulmann, Karsten, primary, Berki, Agnes, primary, Kan, Takatsugu, primary, Abraham, John M., primary, and Meltzer, Stephen J., primary

Published
2023
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45. Supplementary Table 4 from A Multicenter, Double-Blinded Validation Study of Methylation Biomarkers for Progression Prediction in Barrett's Esophagus

Author

Jin, Zhe, primary, Cheng, Yulan, primary, Gu, Wen, primary, Zheng, Yingye, primary, Sato, Fumiaki, primary, Mori, Yuriko, primary, Olaru, Alexandru V., primary, Paun, Bogdan C., primary, Yang, Jian, primary, Kan, Takatsugu, primary, Ito, Tetsuo, primary, Hamilton, James P., primary, Selaru, Florin M., primary, Agarwal, Rachana, primary, David, Stefan, primary, Abraham, John M., primary, Wolfsen, Herbert C., primary, Wallace, Michael B., primary, Shaheen, Nicholas J., primary, Washington, Kay, primary, Wang, Jean, primary, Canto, Marcia Irene, primary, Bhattacharyya, Achyut, primary, Nelson, Mark A., primary, Wagner, Paul D., primary, Romero, Yvonne, primary, Wang, Kenneth K., primary, Feng, Ziding, primary, Sampliner, Richard E., primary, and Meltzer, Stephen J., primary

Published
2023
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47. Three-Time-Point PET Analysis of68Ga-FAPI-46 in a Variety of Cancers

Author

Naeimi, Mahnoosh, primary, Choyke, Peter L., additional, Dendl, Katharina, additional, Mori, Yuriko, additional, Staudinger, Fabian, additional, Watabe, Tadashi, additional, Koerber, Stefan A., additional, Röhrich, Manuel, additional, Debus, Jürgen, additional, Kratochwil, Clemens, additional, Haberkorn, Uwe, additional, and Giesel, Frederik L., additional

Published
2022
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48. Head-to-Head Intra-Individual Comparison of Biodistribution and Tumor Uptake of [ 18 F]FAPI-74 with [ 18 F]FDG in Patients with PDAC: A Prospective Exploratory Study.

Author

Novruzov, Emil, Giesel, Frederik L., Mori, Yuriko, Choyke, Peter L., Dabir, Mardjan, Mamlins, Eduards, Schmitt, Dominik, Antke, Christina, Pinto, Claudio, Soza-Ried, Cristian, Fernandez, Rene, Amaral, Horacio, Kramer, Vasko, and Badinez, Leonardo

Subjects
PANCREATIC tumors, RESEARCH, FIBROBLASTS, RADIOISOTOPES, RETROSPECTIVE studies, GALLIUM isotopes, DUCTAL carcinoma, CANCER, RADIOPHARMACEUTICALS, POSITRON emission tomography, DESCRIPTIVE statistics, DEOXY sugars, COMPUTED tomography, DATA analysis software, COMBINED modality therapy, LONGITUDINAL method
Abstract

Simple Summary: The roll-out of the novel pan-cancer tracer family, fibroblast activation protein (FAP) ligands, has opened a new avenue for the diagnosis of numerous epithelial malignancies. These ligands bind to these transmembrane proteins with enzymatic activity, which is predominantly found on the cell membranes of cancer-associated fibroblasts and regulate the interaction of tumor cells and the tumor microenvironment. The upregulation of these membrane proteins enhances tumor growth and leads to poor outcomes. The first studies with Ga-labeled FAP ligands in patients with pancreatic cancer led to very promising results. However, due to production and financial challenges of 68Ga-labeling, 18F-labeled FAP ligands emerge as the "diagnostic" FAP-tracer with the potential of widespread, economical use in regular healthcare. With this monocentric, prospective study, we aimed to investigate the utility of [18F]FAPI-74 PET/CT examination in patients with pancreatic cancer. Background: Radiolabeled fibroblast activation protein (FAP) ligands, a novel class of tracers for PET/CT imaging, have demonstrated very promising results in various oncological, as well as in some benign, diseases with long-term potential to supplant the current pan-cancer agent [18F]FDG in some cancer types. Pancreatic ductal carcinoma (PDAC) belongs to the group of epithelial malignancies with a strong so-called "desmoplastic reaction", leading to a prominent tumor stroma with cancer-associated fibroblasts that exhibit a marked overexpression of fibroblast activation protein (FAP). The first clinical experiences in PDAC with 68Ga-labeled FAP ligands suggested superior sensitivity to [18F]FDG. However, there is limited data with 18F-labeled FAP derivatives, i.e. [18F]FAPI-74, yet prospective single- and multicenter trials are already ongoing. In this proof-of-concept study, we sought to evaluate the biodistribution, tumor uptake, and lesion detectability in patients with PDAC using [18F]FAPI-74 PET/CT as compared to [18F]FDG PET/CT scans for staging. Methods: This study includes 7 patients (median age 69) who underwent both [18F]FDG PET/CT with contrast-enhancement and [18F]FAPI-74 PET with low-dose CT for primary staging (n = 3) and therapy response control after neoadjuvant (n = 1) or re-staging after palliative therapy (n = 3). The mean interval between PET scans was 11 ± 4 days (range 1–15 days). The [18F]FDG and [18F]FAPI-74 PET/CT scans were acquired at 64 ± 4.1 min (range 61–91 min) and 66.4 ± 6.3 min (range 60–76 min), respectively, after administration of 200 ± 94 MBq (range 79–318 MBq) and 235 ± 88 MBq (range 90–321 MBq), respectively. Quantification of tracer uptake was determined with SUVmax and SUVmean. Furthermore, the tumor-to-background ratio (TBR) was derived by dividing the SUVmax of tumor lesions by the SUVmax of adipose tissue, skeletal muscle, and blood pool. Results: Overall, 32 lesions were detected in 7 patients including primary (n = 7), lung (n = 7), bone (n = 3), lymph node (n = 13), and peritoneal metastases (n = 2). [18F]FAPI-74 detected 22% more lesions compared with [18F]FDG with a better TBR and visual lesion delineation. In one patient the primary lesion could be detected unequivocally with [18F]FAPI-74 but was missed by [18F]FDG imaging. Altogether, most of the lesions demonstrated markedly elevated uptake of [18F]FAPI-74 with a simultaneous lower uptake in the background, providing a very high visual contrast. Conclusion: To the best of our knowledge, this is the first, prospective, intra-individual investigation comparing [18F]FAPI-74 with [18F]FDG imaging in PDAC with encouraging results. These pivotalresults supporta larger, multicentric, prospective study to determine the value of [18F]FAPI-74 in detecting and staging PDAC in comparison with current standard of care imaging. [ABSTRACT FROM AUTHOR]

Published
2023
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49. Intra-Individual Comparison of Physiologic [ 68 Ga]Ga-PSMA-11 and [ 18 F]PSMA-1007 Uptake in Ganglia in Patients with Prostate Cancer: A Retrospective, Monocentric Analysis.

Author

Novruzov, Emil, Schmitt, Dominik, Mattes-György, Katalin, Beu, Markus, Mori, Yuriko, Dabir, Mardjan, Radtke, Jan Philipp, Niegisch, Günter, Albers, Peter, Schimmöller, Lars, Antoch, Gerald, Antke, Christina, Giesel, Frederik L., and Mamlins, Eduards

Subjects
GANGLIA, ANALYSIS of variance, RETROSPECTIVE studies, ACQUISITION of data, RADIOISOTOPES, MEDICAL records, POSITRON emission tomography, DESCRIPTIVE statistics, PROSTATE tumors, LONGITUDINAL method
Abstract

Simple Summary: Since the introduction of PSMA imaging around a decade ago, the faint tracer uptake of ganglia in the neck, abdomen, and presacral region has been an imaging challenge due to difficult discrimination from suspicious lymph nodes. Moreover, PSMA tracers labelled with different radionuclides demonstrate varying levels of ganglion uptake despite having the same target structure on the cell membrane, resulting in distinct imaging pitfall patterns. Our study aims to investigate the underlying mechanisms of the varying detectability of PSMA ligands labelled with different radionuclides. Background: Several studies indicate, particularly in the case of [18F]PSMA-1007, a relatively high rate of detection of ganglia in PSMA PET imaging. Ganglia are an integral part of the sympathetic portion of the autonomous nervous system. To date, no studies have directly compared [68Ga]Ga-PSMA-11 and [18F]PSMA-1007 ganglionic uptake intra-individually and analyzed the underlying molecular and physical mechanisms of different detection rates. With this monocentric retrospective study, we sought to evaluate the intra-individual physiological ganglion uptake of these different PSMA ligands in evidence-based imaging for prostate cancer. Methods: Our cohort consists of 19 male patients (median age 72 ± 9 with a range of 56–85) with biochemical recurrence of prostate cancer who underwent both [68Ga]Ga-PSMA-11 and [18F]PSMA-1007 PET/CT in our clinic on the same scanner per standard care between March 2015 and March 2022. Tracer uptake was quantified according to maximum standardized uptake value (SUVmax) for both [68Ga]Ga-PSMA-11 and [18F]PSMA-1007 PET/CT scans. Ganglia-to-background ratios (GBRs) were determined to quantify the image contrast through dividing the SUVmax of the ganglia by the background value (SUVmax of blood pool in the descending aorta, fatty tissue, and skeletal muscle in gluteal region). We used descriptive analyses for demographics and tumor characteristics and performed two-way repeated-measures ANOVA (analysis of variance) for SUV metrics including GBR measurements. Results: In total, we examined 101 ganglia with [18F]PSMA-1007 scanning, localized mostly in pairs as stellate, coeliac, and sacral, of which 76 were also detected with [68Ga]Ga-PSMA-11 PET/CT scanning. There was no statistically significant difference in PSMA uptake in terms of SUVmax between [18F]PSMA-1007 and [68Ga]Ga-PSMA-11 (p value: 0.052). In contrast, the comparison of GBRs revealed a higher detectability rate of ganglia with [18F]PSMA-1007 imaging (p < 0.001). Furthermore, a separate comparison of ganglia with respect to their anatomical location also demonstrated statistically significant differences both within and between [18F]PSMA-1007 and [68Ga]Ga-PSMA-11 PET/CT scans. Conclusion: Given the impression of more accentuated [18F]PSMA-1007 uptake in ganglia compared with 68Ga-labelled counterparts, our study demonstrated that the better detectability of ganglia is not due to more intense [18F]PSMA-1007 uptake by these small structures but to much more favorable physical properties of the radionuclide 18F. The most relevant limitations of our study are its retrospective design and the small patient cohort. [ABSTRACT FROM AUTHOR]

Published
2023
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