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2. Feasibility of a screening algorithm for chronic thromboembolic pulmonary hypertension: The OSIRIS study

Author

Otero, Remedios, Lobo, José Luis, López, Raquel, Fernández, Carmen, Jiménez, David, Muriel, Alfonso, Alfonso, María, Ballaz, Aitor, Núñez-Ares, Ana, Rodríguez-Matute, Consolación, de Miguel-Díez, Javier, Rodríguez-Chiaradía, Diego Agustín, Alcalde, Mercedes, Elías, Teresa, Jara-Palomares, Luis, Rivas, Agustina, Alonso, Ángel, García-Ortega, Alberto, Sancho, Teresa, Morillo, Raquel, García-Bragado, Fernando, Hernández-Blasco, Luis, Uresandi, Fernando, Madridano, Olga, Agüero, Ramón, and Monreal, Manuel

Published
2023
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5. Different performance of three point-of-care SARS-CoV-2 antigen detection devices in symptomatic patients and close asymptomatic contacts: a real-life study

Author

Adán, Iván, Adán, Javier, Alcalá, Luis, Alonso, Roberto, Álvarez-Uría, Ana, Bouza, Emilio, Catalán, Pilar, Escribano, Pilar, Estévez, Agustín, Fernández-Del Rey, Rocío, Galar, Alicia, García de Viedma, Darío, González, Pedro, Gómez-Núñez, Ana, Guinea, Jesús, Herranz, Marta, Kestler, Marta, Machado, Marina, Marín, Mercedes, Muñoz, Patricia, Olmedo, María, Ortiz, Javier, Palomo, María, Pérez-Granda, María Jesús, Pérez, Laura, Rincón, Cristina, Rodríguez, Sara, Rodríguez, Belén, Ruiz-Serrano, María Jesús, Valerio, Maricela, Vidán, Maite, María Alonso Blanco, Ana, Coca Escribano, Elena, Blázquez Andrés, Susana, Sastre Páez, María Sonsoles, Vega López, Patricia, Díez Vaquero, Lorena, Sandoval Montejo, María Carmen, Pinto Zurita, Jannet, Jiménez Otero, Estefanía, Cañón Cañón, Carolina, Castro Romaní, Marisol, Villamañán Lobo, David, Roca Sánchez, Susana, López Rodríguez, M. Estrella, Jiménez Morillo, Raquel, Plaza Rivera, Sara, Zaragoza Vargas, Natalia, Sánchez Sánchez, José Alejandro, Sánchez Carrasco, Cristina, Corral Martínez, Pedro, Valero López, Iván, Ramos del, Río Lourdes, Huertas Uhagón, María, Martín Francisco María de la, Peña, Cañas Zuluaga, Ángela Bibiana, Heras Martín, Laura, García García, Ana Isabel, Sevilla Aguerre, Ainhoa, López Alonso, Ana Belén, Sánchez Sánchez, Luis Alberto, Cánovas Martínez, Miriam, Roy Zafra, Rut, García Ramos, Aitor, Sánchez-Pulido, Ana-Erika, González-Leiva, José, and Valero-López, Iván

Published
2022
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7. Guía práctica para técnico superior de laboratorio de diagnóstico clínico y biomédico

Author

Iván Sanz Muñoz, Raquel Moreno Mayordomo, Wysali Trapiello Fernández, Jose Manuel Mendez Legaza, Cristina Andrés Ledesma, María José Lázaro Morillo, Raquel De la Cruz Perez and Iván Sanz Muñoz, Raquel Moreno Mayordomo, Wysali Trapiello Fernández, Jose Manuel Mendez Legaza, Cristina Andrés Ledesma, María José Lázaro Morillo, Raquel De la Cruz Perez

Published
2019

10. DVT Management and Outcome Trends, 2001 to 2014

Author

Monreal, Manuel, Decousus, Hervè, Prandoni, Paolo, Brenner, Benjamin, Barba, Raquel, Di Micco, Pierpaolo, Bertoletti, Laurent, Schellong, Sebastian, Tzoran, Inna, Reis, Abilio, Bosevski, Marijan, Bounameaux, Henri, Malý, Radovan, Wells, Philip, Papadakis, Manolis, Agudo, P., Aibar, M.A., Akasbi, M., Alcalde-Manero, M., Andújar, V., Arcelus, J.I., Ballaz, A., Barba, R., Barrón, M., Barrón-Andrés, B., Bascuñana, J., Blanco-Molina, A., Cañas, I., Casado, I., de Miguel, J., del Toro, J., Díaz, S., Díaz-Peromingo, J.A., Falgá, C., Fernández-Capitán, C., Font, C., Font, L., Gallego, P., García-Bragado, F., García-Rodenas, M., Gómez, V., González, C.J., Grau, E., Guirado, L., Gutiérrez, J., Hernández, G., Hernández-Blasco, L., Isern, V., Jara-Palomares, L., Jaras, M.J., Jiménez, D., Lobo, J.L., López-Jiménez, L., López-Reyes, R., López-Sáez, J.B., Lorente, M.A., Lorenzo, A., Madridano, O., Maestre, A., Marchena, P.J., Martín, M., Martín-Antorán, J.M., Martín-Martos, F., Monreal, M., Morales, M.V., Nauffal, D., Nieto, J.A., Nieto, S., Núñez, M.J., Orbegoso, C., Otalora, S., Otero, R., Pagán, B., Pedrajas, J.M., Pérez, C., Pérez, G., Peris, M.L., Pons, I., Porras, J.A., Reig, O., Riera-Mestre, A., Rivas, A., Rodríguez, C., Rodríguez-Dávila, M.A., Rosa, V., Rosa-Murillo, A.S., Ruiz-Giménez, N., Sahuquillo, J.C., Sala, M.C., Sampériz, A., Sánchez, R., Sanz, O., Soler, S., Suriñach, J.M., Tolosa, C., Trujillo-Santos, J., Uresandi, F., Valero, B., Valle, R., Vela, J., Vidal, G., Vilar, C., Villalta, J., Xifre, B., Vanassche, T., Verhamme, P., Wells, P., Hirmerova, J., Malý, R., Tomko, T., Celis, G., Salgado, E., Sánchez, G.T., Bertoletti, L., Bura-Riviere, A., Farge-Bancel, D., Hij, A., Mahé, I., Merah, A., Quere, I., Papadakis, M., Braester, A., Brenner, B., Tzoran, I., Apollonio, A., Barillari, G., Bertone, A., Bilora, F., Bucherini, E., Ciammaichella, M., De Ciantis, P., Dentali, F., Di Micco, P., Duce, R., Ferrazzi, P., Grandone, E., Lessiani, G., Lodigiani, C., Mastroiacovo, D., Pace, F., Pesavento, R., Pinelli, M., Poggio, R., Prandoni, P., Rosa, M., Rota, L., Tiraferri, E., Tonello, D., Tufano, A., Venturelli, U., Visonà, A., Zalunardo, B., Drucka, E., Kigitovica, D., Skride, A., Mafalda, A., Ribeiro, J.L., Sousa, M.S., Bosevski, M., Zdraveska, M., Bounameaux, H., Mazzolai, L., Morillo, Raquel, Jiménez, David, Aibar, Miguel Ángel, Mastroiacovo, Daniela, Wells, Philip S., Sampériz, Ángel, Saraiva de Sousa, Marta, Muriel, Alfonso, and Yusen, Roger D.

Published
2016
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12. Different performance of three point-of-care SARS-CoV-2 antigen detection devices in symptomatic patients and close asymptomatic contacts: a real-life study

Author

Escribano, Pilar, primary, Sánchez-Pulido, Ana-Erika, additional, González-Leiva, José, additional, Valero-López, Iván, additional, Catalán, Pilar, additional, Muñoz, Patricia, additional, Guinea, Jesús, additional, Adán, Iván, additional, Adán, Javier, additional, Alcalá, Luis, additional, Alonso, Roberto, additional, Álvarez-Uría, Ana, additional, Bouza, Emilio, additional, Escribano, Pilar, additional, Estévez, Agustín, additional, Fernández-Del Rey, Rocío, additional, Galar, Alicia, additional, García de Viedma, Darío, additional, González, Pedro, additional, Gómez-Núñez, Ana, additional, Herranz, Marta, additional, Kestler, Marta, additional, Machado, Marina, additional, Marín, Mercedes, additional, Olmedo, María, additional, Ortiz, Javier, additional, Palomo, María, additional, Pérez-Granda, María Jesús, additional, Pérez, Laura, additional, Rincón, Cristina, additional, Rodríguez, Sara, additional, Rodríguez, Belén, additional, Ruiz-Serrano, María Jesús, additional, Valerio, Maricela, additional, Vidán, Maite, additional, María Alonso Blanco, Ana, additional, Coca Escribano, Elena, additional, Blázquez Andrés, Susana, additional, Sastre Páez, María Sonsoles, additional, Vega López, Patricia, additional, Díez Vaquero, Lorena, additional, Sandoval Montejo, María Carmen, additional, Pinto Zurita, Jannet, additional, Jiménez Otero, Estefanía, additional, Cañón Cañón, Carolina, additional, Castro Romaní, Marisol, additional, Villamañán Lobo, David, additional, Roca Sánchez, Susana, additional, López Rodríguez, M. Estrella, additional, Jiménez Morillo, Raquel, additional, Plaza Rivera, Sara, additional, Zaragoza Vargas, Natalia, additional, Sánchez Sánchez, José Alejandro, additional, Sánchez Carrasco, Cristina, additional, Corral Martínez, Pedro, additional, Valero López, Iván, additional, Ramos del, Río Lourdes, additional, Huertas Uhagón, María, additional, Martín Francisco María de la, Peña, additional, Cañas Zuluaga, Ángela Bibiana, additional, Heras Martín, Laura, additional, García García, Ana Isabel, additional, Sevilla Aguerre, Ainhoa, additional, López Alonso, Ana Belén, additional, Sánchez Sánchez, Luis Alberto, additional, Cánovas Martínez, Miriam, additional, Roy Zafra, Rut, additional, and García Ramos, Aitor, additional

Published
2022
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17. Randomised controlled trial of a prognostic assessment and management pathway to reduce the length of hospital stay in normotensive patients with acute pulmonary embolism

Author

Jiménez, David, primary, Rodríguez, Carmen, additional, León, Francisco, additional, Jara-Palomares, Luis, additional, López-Reyes, Raquel, additional, Ruiz-Artacho, Pedro, additional, Elías, Teresa, additional, Otero, Remedios, additional, García-Ortega, Alberto, additional, Rivas-Guerrero, Agustina, additional, Abelaira, Jaime, additional, Jiménez, Sonia, additional, Muriel, Alfonso, additional, Morillo, Raquel, additional, Barrios, Deisy, additional, Le Mao, Raphael, additional, Yusen, Roger D., additional, Bikdeli, Behnood, additional, Monreal, Manuel, additional, and Lobo, José Luis, additional

Published
2021
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19. Refinement of a modified simplified Pulmonary Embolism Severity Index for elderly patients with acute pulmonary embolism

Author

Morillo, Raquel, primary, Jiménez, David, additional, Bikdeli, Behnood, additional, Rodríguez, Carmen, additional, Tenes, Andrés, additional, Yamashita, Yugo, additional, Morimoto, Takeshi, additional, Kimura, Takeshi, additional, Vidal, Gemma, additional, Ruiz-Giménez, Nuria, additional, Espitia, Olivier, additional, and Monreal, Manuel, additional

Published
2021
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21. Right heart thrombi in pulmonary embolism

Author

Barrios, Deisy, Rosa-Salazar, Vladimir, Jimenez, David, Morillo, Raquel, Muriel, Alfonso, del Toro, Jorge, Lopez-Jimenez, Luciano, Farge-Bancel, Dominique, Yusen, Roger, Monreal, Manuel, RIETE Investigators, [Barrios, Deisy] Ramon & Cajal Hosp, Resp Dept, Madrid, Spain, [Jimenez, David] Ramon & Cajal Hosp, Resp Dept, Madrid, Spain, [Morillo, Raquel] Ramon & Cajal Hosp, Resp Dept, Madrid, Spain, [Muriel, Alfonso] Ramon & Cajal Hosp, Resp Dept, Madrid, Spain, [Barrios, Deisy] Univ Alcala IRYCIS, Madrid, Spain, [Jimenez, David] Univ Alcala IRYCIS, Madrid, Spain, [Morillo, Raquel] Univ Alcala IRYCIS, Madrid, Spain, [Muriel, Alfonso] Univ Alcala IRYCIS, Madrid, Spain, [Rosa-Salazar, Vladimir] Hosp Clin Univ Virgen Arrixaca, Dept Internal Med, Murcia, Spain, [del Toro, Jorge] Hosp Gen Univ Gregorio Maranon, Dept Internal Med, Madrid, Spain, [Lopez-Jimenez, Luciano] Hosp Gen Univ Gregorio Maranon, Dept Internal Med, Madrid, Spain, [Farge-Bancel, Dominique] Hosp Gen Univ Gregorio Maranon, Dept Internal Med, Madrid, Spain, [Jimenez, David] Hosp Univ Reina Sofia, Dept Internal Med, Cordoba, Spain, [Farge-Bancel, Dominique] Hosp Univ Reina Sofia, Dept Internal Med, Cordoba, Spain, [Barrios, Deisy] Dept Internal Med & Pathol, Hdpital St Louis, Paris, France, [Morillo, Raquel] Washington Univ Sch Med, Div Pulm & Crit Care Med & Gen Med Sci, St Louis, MO USA, [Farge-Bancel, Dominique] Washington Univ Sch Med, Div Pulm & Crit Care Med & Gen Med Sci, St Louis, MO USA, [Rosa-Salazar, Vladimir] Univ Catalic Murcia, Hosp Univ Germans Trias Pujol, Dept Internal Med, Barcelona, Spain, [Jimenez, David] Univ Catalic Murcia, Hosp Univ Germans Trias Pujol, Dept Internal Med, Barcelona, Spain, [Farge-Bancel, Dominique] Univ Catalic Murcia, Hosp Univ Germans Trias Pujol, Dept Internal Med, Barcelona, Spain, Sanofi Spain, and Bayer Pharma AG

Subjects
Pulmonary and Respiratory Medicine, medicine.medical_specialty, Outcomes, 030204 cardiovascular system & hematology, 03 medical and health sciences, 0302 clinical medicine, Internal medicine, Diagnosis, medicine, Systole, business.industry, Retrospective cohort study, Odds ratio, medicine.disease, Comorbidity, Cardiovascular physiology, Pulmonary embolism, Management, Index, Blood pressure, 030228 respiratory system, Heart failure, Cardiology, Therapy, business, Venous thromboembolism
Abstract

There is a lack of comprehensive data on the prevalence, predictors and prognostic significance of right heart thrombi (RHT) in pulmonary embolism.In this study of patients with pulmonary embolism from the Registro Informatizado de la Enfermedad TromboEmbólica (RIETE) registry, we assessed the prevalence and predictors of RHT, and the association between the presence of RHT and the outcomes of all-cause mortality, pulmonary embolism-related mortality, recurrences, and major bleeding through 30 days after initiation of pulmonary embolism treatment.Of 12 441 patients with pulmonary embolism and baseline echocardiographic data, 2.6% had RHT. The following increased the risk of RHT: younger age, previous bleeding, congestive heart failure, cancer, syncope, systolic blood pressure versus 0.7%; p=0.04). Major bleeding was similar in patients with and without RHT.In patients presenting with pulmonary embolism, RHT is relatively infrequent. Patients with RHT had a worse outcome when compared with those without RHT.

Published
2016

22. Implications of Abnormal Troponin Levels With Normal Right Ventricular Function in Normotensive Patients With Acute Pulmonary Embolism

Author

Mirambeaux, Rosa, primary, Le Mao, Raphael, additional, Muriel, Alfonso, additional, Pintado, Beatriz, additional, Pérez, Andrea, additional, Velasco, Diurbis, additional, Lobo, José Luis, additional, Barrios, Deisy, additional, Morillo, Raquel, additional, Bikdeli, Behnood, additional, and Jiménez, David, additional

Published
2020
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23. Intermediate-High Risk Pulmonary Embolism

Author

Mirambeaux, Rosa, additional, León, Francisco, additional, Bikdeli, Behnood, additional, Morillo, Raquel, additional, Barrios, Deisy, additional, Mercedes, Edwin, additional, Moores, Lisa, additional, Tapson, Victor, additional, Yusen, Roger D., additional, and Jiménez, David, additional

Published
2019
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28. Chronic thromboembolic pulmonary hypertension treatment and sex: Systematic review and meta-analysis

Author

Tenes, Andrés, García-Sánchez, Aldara, Pintado-Cort, Beatriz, González-Castro, Sara, Briceño, Winnifer, Durán, Diego, Morillo, Raquel, and Jiménez, David

Abstract

Chronic thromboembolic pulmonary hypertension (CTEPH) is a complication of pulmonary embolism and a major cause of chronic pulmonary hypertension leading to right heart failure and death. While pulmonary endarterectomy is the treatment of choice, some patients might benefit from medical therapy or balloon pulmonary angioplasty. Sex differences in outcomes of these therapies are not well characterized.

Published
2024
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30. Assessment of coexisting deep vein thrombosis for risk stratification of acute pulmonary embolism

Author

Quezada, Carlos Andrés, primary, Bikdeli, Behnood, additional, Barrios, Deisy, additional, Morillo, Raquel, additional, Nieto, Rosa, additional, Chiluiza, Diana, additional, Barbero, Esther, additional, Guerassimova, Ina, additional, García, Aldara, additional, Yusen, Roger D., additional, Jiménez, David, additional, Rodríguez, Consolación, additional, Vivancos, Jorge, additional, Marín, Jesús, additional, Oribe, Mikel, additional, Ballaz, Aitor, additional, Abaitúa, Jose María, additional, Velasco, Sonia, additional, Barrón, Manuel, additional, Lladó, María, additional, Rodrigo, Carmen, additional, Alonso, Luis Javier, additional, Rabuñal, Ramón, additional, Castro, Olalla, additional, Iglesias, Concepción, additional, Testa, Ana, additional, Gómez, Vicente, additional, Gorospe, Luis, additional, Briongos, Sem, additional, del Rey, José Manuel, additional, Álvarez, Celso, additional, Rodríguez, Nuria, additional, Prieto, Amador, additional, Martín, María, additional, Navarro, Carmen, additional, López, Mónica, additional, Castañer, Eva, additional, Guillaumet, Eva, additional, Otero, Remedios, additional, Elías, Teresa, additional, Serrano, Pilar, additional, López, Francisco, additional, Valle, Reina, additional, Piret, María Victoria, additional, Lucio, Pilar, additional, Cuesta, José María, additional, Nauffal, Dolores, additional, Ballester, Marta, additional, Pamies, José, additional, Osa, Ana, additional, Lobo, José Luis, additional, Zorrilla, Vanesa, additional, Pozo, Delfina, additional, Alonso, Ángel, additional, Conget, Francisco, additional, Santolaria, Miguel Ángel, additional, González, Mariano, additional, and de Benito, José Luis, additional

Published
2018
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31. Prognostic impact of copeptin in pulmonary embolism: a multicentre validation study

Author

Hellenkamp, Kristian, primary, Pruszczyk, Piotr, additional, Jiménez, David, additional, Wyzgał, Anna, additional, Barrios, Deisy, additional, Ciurzyński, Michał, additional, Morillo, Raquel, additional, Hobohm, Lukas, additional, Keller, Karsten, additional, Kurnicka, Katarzyna, additional, Kostrubiec, Maciej, additional, Wachter, Rolf, additional, Hasenfuß, Gerd, additional, Konstantinides, Stavros, additional, and Lankeit, Mareike, additional

Published
2018
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36. Efficacy and safety outcomes of recanalisation procedures in patients with acute symptomatic pulmonary embolism: systematic review and network meta-analysis

Author

Jimenez, David, primary, Martin-Saborido, Carlos, additional, Muriel, Alfonso, additional, Zamora, Javier, additional, Morillo, Raquel, additional, Barrios, Deisy, additional, Klok, Frederikus A, additional, Huisman, Menno V, additional, Tapson, Victor, additional, and Yusen, Roger D, additional

Published
2017
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40. Right heart thrombi in pulmonary embolism

Author

Barrios, Deisy, primary, Rosa-Salazar, Vladimir, additional, Jiménez, David, additional, Morillo, Raquel, additional, Muriel, Alfonso, additional, del Toro, Jorge, additional, López-Jiménez, Luciano, additional, Farge-Bancel, Dominique, additional, Yusen, Roger, additional, and Monreal, Manuel, additional

Published
2016
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42. DVT Management and Outcome Trends, 2001 to 2014

Author

Morillo, Raquel, primary, Jiménez, David, additional, Aibar, Miguel Ángel, additional, Mastroiacovo, Daniela, additional, Wells, Philip S., additional, Sampériz, Ángel, additional, Saraiva de Sousa, Marta, additional, Muriel, Alfonso, additional, Yusen, Roger D., additional, Monreal, Manuel, additional, Decousus, Hervè, additional, Prandoni, Paolo, additional, Brenner, Benjamin, additional, Barba, Raquel, additional, Di Micco, Pierpaolo, additional, Bertoletti, Laurent, additional, Schellong, Sebastian, additional, Tzoran, Inna, additional, Reis, Abilio, additional, Bosevski, Marijan, additional, Bounameaux, Henri, additional, Malý, Radovan, additional, Wells, Philip, additional, Papadakis, Manolis, additional, Agudo, P., additional, Aibar, M.A., additional, Akasbi, M., additional, Alcalde-Manero, M., additional, Andújar, V., additional, Arcelus, J.I., additional, Ballaz, A., additional, Barba, R., additional, Barrón, M., additional, Barrón-Andrés, B., additional, Bascuñana, J., additional, Blanco-Molina, A., additional, Cañas, I., additional, Casado, I., additional, de Miguel, J., additional, del Toro, J., additional, Díaz, S., additional, Díaz-Peromingo, J.A., additional, Falgá, C., additional, Fernández-Capitán, C., additional, Font, C., additional, Font, L., additional, Gallego, P., additional, García-Bragado, F., additional, García-Rodenas, M., additional, Gómez, V., additional, González, C.J., additional, Grau, E., additional, Guirado, L., additional, Gutiérrez, J., additional, Hernández, G., additional, Hernández-Blasco, L., additional, Isern, V., additional, Jara-Palomares, L., additional, Jaras, M.J., additional, Jiménez, D., additional, Lobo, J.L., additional, López-Jiménez, L., additional, López-Reyes, R., additional, López-Sáez, J.B., additional, Lorente, M.A., additional, Lorenzo, A., additional, Madridano, O., additional, Maestre, A., additional, Marchena, P.J., additional, Martín, M., additional, Martín-Antorán, J.M., additional, Martín-Martos, F., additional, Monreal, M., additional, Morales, M.V., additional, Nauffal, D., additional, Nieto, J.A., additional, Nieto, S., additional, Núñez, M.J., additional, Orbegoso, C., additional, Otalora, S., additional, Otero, R., additional, Pagán, B., additional, Pedrajas, J.M., additional, Pérez, C., additional, Pérez, G., additional, Peris, M.L., additional, Pons, I., additional, Porras, J.A., additional, Reig, O., additional, Riera-Mestre, A., additional, Rivas, A., additional, Rodríguez, C., additional, Rodríguez-Dávila, M.A., additional, Rosa, V., additional, Rosa-Murillo, A.S., additional, Ruiz-Giménez, N., additional, Sahuquillo, J.C., additional, Sala, M.C., additional, Sampériz, A., additional, Sánchez, R., additional, Sanz, O., additional, Soler, S., additional, Suriñach, J.M., additional, Tolosa, C., additional, Trujillo-Santos, J., additional, Uresandi, F., additional, Valero, B., additional, Valle, R., additional, Vela, J., additional, Vidal, G., additional, Vilar, C., additional, Villalta, J., additional, Xifre, B., additional, Vanassche, T., additional, Verhamme, P., additional, Wells, P., additional, Hirmerova, J., additional, Malý, R., additional, Tomko, T., additional, Celis, G., additional, Salgado, E., additional, Sánchez, G.T., additional, Bertoletti, L., additional, Bura-Riviere, A., additional, Farge-Bancel, D., additional, Hij, A., additional, Mahé, I., additional, Merah, A., additional, Quere, I., additional, Papadakis, M., additional, Braester, A., additional, Brenner, B., additional, Tzoran, I., additional, Apollonio, A., additional, Barillari, G., additional, Bertone, A., additional, Bilora, F., additional, Bucherini, E., additional, Ciammaichella, M., additional, De Ciantis, P., additional, Dentali, F., additional, Di Micco, P., additional, Duce, R., additional, Ferrazzi, P., additional, Grandone, E., additional, Lessiani, G., additional, Lodigiani, C., additional, Mastroiacovo, D., additional, Pace, F., additional, Pesavento, R., additional, Pinelli, M., additional, Poggio, R., additional, Prandoni, P., additional, Rosa, M., additional, Rota, L., additional, Tiraferri, E., additional, Tonello, D., additional, Tufano, A., additional, Venturelli, U., additional, Visonà, A., additional, Zalunardo, B., additional, Drucka, E., additional, Kigitovica, D., additional, Skride, A., additional, Mafalda, A., additional, Ribeiro, J.L., additional, Sousa, M.S., additional, Bosevski, M., additional, Zdraveska, M., additional, Bounameaux, H., additional, and Mazzolai, L., additional

Published
2016
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43. Efficacy and safety outcomes of recanalisation procedures in patients with acute symptomatic pulmonary embolism: systematic review and network meta-analysis.

Author

Jimenez, David, Martin-Saborido, Carlos, Muriel, Alfonso, Zamora, Javier, Morillo, Raquel, Barrios, Deisy, Klok, Frederikus A., Huisman, Menno V., Tapson, Victor, and Yusen, Roger D.

Subjects
PULMONARY embolism, THROMBOLYTIC therapy, DRUG efficacy, CATHETERS, ANTICOAGULANTS, RANDOMIZED controlled trials, THERAPEUTICS, FIBRINOLYTIC agents, CINAHL database, HEMORRHAGE, MEDICAL information storage & retrieval systems, META-analysis, SYSTEMATIC reviews, ACUTE diseases, SWAN-Ganz catheterization
Abstract

Background: We aimed to review the efficacy and safety of recanalisation procedures for the treatment of PE.Methods: We searched PubMed, the Cochrane Library, EMBASE, EBSCO, Web of Science and CINAHL databases from inception through 31 July 2015 and included randomised clinical trials that compared the effect of a recanalisation procedure versus each other or anticoagulant therapy in patients diagnosed with PE. We used network meta-analysis and multivariate random-effects meta-regression to estimate pooled differences between each intervention and meta-regression to assess the association between trial characteristics and the reported effects of recanalisation procedures versus anticoagulation.Results: For all-cause mortality, there were no significant differences in event rates between any of the recanalisation procedures and anticoagulant treatment (full-dose thrombolysis: OR 0.60; 95% CI0.36 to 1.01; low-dose thrombolysis: 0.47; 95% CI 0.14 to 1.59; and catheter-associated thrombolysis: 0.31; 95% CI 0.01 to 7.96). Full-dose thrombolysis increased the risk of major bleeding (2.00; 95% CI 1.06 to 3.78) compared with anticoagulation. Catheter-directed thrombolysis was associated with the lowest probability of dying (surface under the cumulative ranking curve (SUCRA), 0.67), followed by low-dose thrombolysis (SUCRA, 0.66) and full-dose thrombolysis (SUCRA, 0.55). Similarly, low-dose thrombolysis was associated with the lowest probability of major bleeding (SUCRA, 0.61), followed by catheter-directed thrombolysis (SUCRA, 0.54) and full-dose thrombolysis (SUCRA, 0.17). The results were similar in sensitivity analyses based on restricting only to studies in haemodynamically stable patients with PE.Conclusions: In the treatment of PE, recanalisation procedures do not seem to offer a clear advantage compared with standard anticoagulation. Low-dose thrombolysis was associated with the lowest probability of dying and bleeding.Trial Registration Number: PROSPERO CRD42015024670. [ABSTRACT FROM AUTHOR]

Published
2018
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45. Randomised controlled trial of a prognostic assessment and management pathway to reduce the length of hospital stay in normotensive patients with acute pulmonary embolism.

Author

Jiménez D, Rodríguez C, León F, Jara-Palomares L, López-Reyes R, Ruiz-Artacho P, Elías T, Otero R, García-Ortega A, Rivas-Guerrero A, Abelaira J, Jiménez S, Muriel A, Morillo R, Barrios D, Le Mao R, Yusen RD, Bikdeli B, Monreal M, and Lobo JL

Subjects
Acute Disease, Adult, Humans, Length of Stay, Prognosis, Patient Readmission, Pulmonary Embolism drug therapy, Pulmonary Embolism therapy
Abstract

Background: The length of hospital stay (LOS) for acute pulmonary embolism (PE) varies considerably. Whether the upfront use of a PE prognostic assessment and management pathway is effective in reducing the LOS remains unknown., Methods: We conducted a randomised controlled trial of adults hospitalised for acute PE: patients were assigned either to a prognostic assessment and management pathway involving risk stratification followed by predefined criteria for mobilisation and discharge (intervention group) or to usual care (control group). The primary end-point was LOS. The secondary end-points were the cost of prognostic tests and of hospitalisation, and 30-day clinical outcomes., Results: Of 500 patients who underwent randomisation, 498 were included in the modified intention-to-treat analysis. The median LOS was 4.0 days (interquartile range (IQR) 3.7-4.2 days) in the intervention group and 6.1 days (IQR 5.7-6.5 days) in the control group (p<0.001). The mean total cost of prognostic tests was EUR 174.76 in the intervention group, compared with EUR 233.12 in the control group (mean difference EUR -58.37, 95% CI EUR -84.34- to -32.40). The mean total hospitalisation cost per patient was EUR 2085.66 in the intervention group, compared with EUR 3232.97 in the control group (mean difference EUR -1147.31, 95% CI EUR -1414.97- to -879.65). No significant differences were observed in 30-day readmission (4.0% versus 4.8%), all-cause mortality (2.4% versus 2.0%) or PE-related mortality (0.8% versus 1.2%) rates., Conclusions: The use of a prognostic assessment and management pathway was effective in reducing the LOS for acute PE., Competing Interests: Conflict of interest: D. Jiménez has served as an advisor or consultant for Bayer HealthCare Pharmaceuticals, Boehringer Ingelheim, Bristol-Myers Squibb, Daiichi Sankyo, Leo Pharma, Pfizer, ROVI and Sanofi; served as a speaker or a member of a speakers’ bureau for Bayer HealthCare Pharmaceuticals, Boehringer Ingelheim, Bristol-Myers Squibb, Daiichi Sankyo, Leo Pharma, ROVI and Sanofi; and has received grants for clinical research from Daiichi Sankyo, Sanofi and ROVI. Conflict of interest: C. Rodríguez has nothing to disclose. Conflict of interest: F. León has nothing to disclose. Conflict of interest: L. Jara-Palomares has served as an advisor or consultant for Actelion Pharmaceuticals, Bayer HealthCare Pharmaceuticals, Leo Pharma, Menarini, Pfizer, GSK and ROVI. Conflict of interest: R. López-Reyes has nothing to disclose. Conflict of interest: P. Ruiz-Artacho has nothing to disclose. Conflict of interest: T. Elías has nothing to disclose. Conflict of interest: R. Otero has served as an advisor or consultant for Bayer HealthCare Pharmaceuticals, Leo Pharma, Janssen Pharmaceutical Companies, Merck Sharp & Dohme Corp, ROVI and Sanofi; and received grants for clinical research from Leo Pharma and Bayer Hispania SL. Conflict of interest: A. García-Ortega has nothing to disclose. Conflict of interest: A. Rivas-Guerrero has nothing to disclose. Conflict of interest: J. Abelaria has nothing to disclose. Conflict of interest: S. Jiménez has nothing to disclose. Conflict of interest: A. Muriel has nothing to disclose. Conflict of interest: R. Morillo has nothing to disclose. Conflict of interest: D. Barrios has nothing to disclose. Conflict of interest: R. Le Mao has nothing to disclose. Conflict of interest: R.D. Yusen has received research funding from Bayer HealthCare Pharmaceuticals, Bristol-Myers Squibb, Pfizer and Portola in the past 3 years; and has served as a consultant for Bayer HealthCare, Inc., Bristol-Myers Squibb, GlaxoSmithkline, Janssen, Johnson and Johnson, Ortho Pharmaceuticals, Organon, Pfizer, Portola, Sanofi and SCIOS in the past 3 years. Conflict of interest: B. Bikdeli reports that he is a consulting expert, on behalf of the plaintiff, for litigation related to two specific brand models of inferior vena cava filters. Conflict of interest: M. Monreal has served as an advisor or consultant for Bayer HealthCare Pharmaceuticals, Daiichi Sankyo, Leo Pharma and Sanofi; served as a speaker or a member of a speakers’ bureau for Bayer HealthCare Pharmaceuticals, Daiichi Sankyo, Leo Pharma and Sanofi; and received grants for clinical research from Sanofi and Bayer. Conflict of interest: J.L. Lobo has nothing to disclose., (Copyright ©The authors 2022. For reproduction rights and permissions contact permissions@ersnet.org.)

Published
2022
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