183 results on '"Morishita, Kimberly"'
Search Results
2. Higher concentrations of vitamin D in Canadian children with juvenile idiopathic arthritis compared to healthy controls are associated with more frequent use of vitamin D supplements and season of birth
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Finch, Sarah L., Rosenberg, Alan M., Kusalik, Anthony J., Maleki, Farhad, Rezaei, Elham, Baxter-Jones, Adam, Benseler, Susanne, Boire, Gilles, Cabral, David, Campillo, Sarah, Chédeville, Gaëlle, Chetaille, Anne-Laure, Dancey, Paul, Duffy, Ciaran, Duffy, Karen Watanabe, Guzman, Jaime, Houghton, Kristin, Huber, Adam M., Jurencak, Roman, Lang, Bianca, Laxer, Ron M., Morishita, Kimberly, Oen, Kiem G., Petty, Ross E., Ramsey, Suzanne E., Roth, Johannes, Schneider, Rayfel, Scuccimarri, Rosie, Stringer, Elizabeth, Tse, Shirley M.L., Tucker, Lori B., Turvey, Stuart E., Szafron, Michael, Whiting, Susan, Yeung, Rae SM, and Vatanparast, Hassan
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- 2021
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3. Consensus Treatment Plans for Severe Pediatric Antineutrophil Cytoplasmic Antibody–Associated Vasculitis
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Morishita, Kimberly A., Wagner‐Weiner, Linda, Yen, Eric Y., Sivaraman, Vidya, James, Karen E., Gerstbacher, Dana, Szymanski, Ann M., OʼNeil, Kathleen M., and Cabral, David A.
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- 2022
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4. Anti-LAMP-2 Antibody Seropositivity in Children with Primary Systemic Vasculitis Affecting Medium- and Large-Sized Vessels
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Akbaba, Tayfun Hilmi, primary, Toor, Kirandeep K., additional, Mann, Simranpreet K., additional, Gibson, Kristen M., additional, Alfaro, Gabriel Alejandro, additional, Balci-Peynircioglu, Banu, additional, Cabral, David A., additional, Morishita, Kimberly A., additional, and Brown, Kelly L., additional
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- 2024
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5. 111 - Juvenile Dermatomyositis, Scleroderma, and Vasculitis
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Kim, Susan, Torok, Kathryn S., and Morishita, Kimberly A.
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- 2025
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6. Relationship of Fatigue, Pain Interference, and Physical Disability in Children Newly Diagnosed With Juvenile Idiopathic Arthritis
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Choong, Naomi, Batthish, Michelle, Berard, Roberta A., Chédeville, Gaëlle, Feldman, Brian M., Houghton, Kristin M., Huber, Adam M., James, Sarah, Proulx‐Gauthier, Jean‐Philippe, Rumsey, Dax G., Schmeling, Heinrike, Toupin‐April, Karine, Guzman, Jaime, Cabral, David A., Chédeville, Gaëlle, Duffy, Ciarán M., Gerhold, Kerstin, Guzman, Jaime, Hiraki, Linda, Huber, Adam M., Schmeling, Heinrike, Shiff, Natalie J., Tucker, Lori B., Barsalou, Julie, Basodan, Daniah, Batthish, Michelle, Berard, Roberta A., Blanchette, Nicholas, Boire, Gilles, Bolaria, Roxana, Bruns, Alessandra, Cabral, David, Campillo, Sarah, Cellucci, Tania, Chan, Mercedes, Chédeville, Gaëlle, Chhabra, Amieleena, Couture, Julie, Dancey, Paul, De Bruycker, Jean‐Jacques, Demirkaya, Erkan, Dhalla, Muhammed, Duffy, Ciarán M., El Tal, Talal, Gerschman, Tommy, Guzman, Jaime, Heale, Liane, Herrington, Julie, Houghton, Kristin M., Huber, Adan M., Human, Andrea, Johnson, Nicole, Jurencak, Roman, Lang, Bianca, LeBlanc, Claire, Lim, Lilian, Lim, Lily S. H., Luca, Nadia, McColl, Jeanine, McGrath, Tara, McMillan, Tamara, McPherson, Megan, Miettunen, Paivi, Morishita, Kimberly, Ng, Honyan, Park, Jonathan, Proulx‐Gauthier, Jean‐Philippe, Roth, Johannes, Rozenblyum, Evelyn, Rumsey, Dax G., Schmeling, Heinrike, Scuccimarri, Rosie, Soon, Gordon, Stevenson, Rebeka, Stringer, Elizabeth, Tam, Herman, Tucker, Lori B., Twilt, Marinka, Verstegen, Ruud H. J., and Duffy, Karen Watanabe
- Abstract
Our objectives were to quantify the relationships among fatigue, pain interference, and physical disability in children with juvenile idiopathic arthritis (JIA) and to test whether fatigue mediates the relationship between pain interference and physical disability in JIA. Patients enrolled within three months of JIA diagnosis in the Canadian Alliance of Pediatric Rheumatology Investigators (CAPRI) Registry between February 2017 and May 2023 were included. Their parents completed the Patient‐Reported Outcomes Measurement Information System fatigue and pain interference short proxy questionnaires and the Childhood Health Assessment Questionnaire disability index at registry enrollment. Associations were assessed using Pearson correlations and multiple linear regression. Structural equation modeling (SEM) was used to test if fatigue mediates the relationship between pain interference and physical disability. Among 855 patients (61.4% female, 44.1% with oligoarthritis), most reported fatigue and pain interference scores similar to those in the reference population, but 15.6% reported severe fatigue and 7.3% reported severe pain interference, with wide variation across JIA categories. Fatigue was strongly correlated with pain interference (r = 0.72, P< 0.001) and with physical disability (r= 0.60, P< 0.001). Pain interference (β = 0.027, P< 0.001) and fatigue (β = 0.013, P< 0.001) were both associated with physical disability after controlling for each other and potential confounders. SEM supported our hypothesis that fatigue partially mediates the relationship between pain interference and physical disability. Our findings suggest both fatigue and pain interference are independently associated with physical disability in children newly diagnosed with JIA, and the effect of pain interference may be partly mediated by fatigue.
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- 2024
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7. Granulomatosis with Polyangiitis in Children
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Cabral, David A., Morishita, Kimberly, Sawhney, Sujata, editor, and Aggarwal, Amita, editor
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- 2017
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8. A decade of progress in juvenile idiopathic arthritis treatments and outcomes in Canada: results from ReACCh-Out and the CAPRI registry
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Nguyen, Kelly, primary, Barsalou, Julie, additional, Basodan, Daniah, additional, Batthish, Michelle, additional, Benseler, Susanne M, additional, Berard, Roberta A, additional, Blanchette, Nicholas, additional, Boire, Gilles, additional, Bolaria, Roxana, additional, Bruns, Alessandra, additional, Cabral, David A, additional, Cameron, Bonnie, additional, Campillo, Sarah, additional, Cellucci, Tania, additional, Chan, Mercedes, additional, Chédeville, Gaëlle, additional, Chetaille, Anne-Laure, additional, Chhabra, Amieleena, additional, Couture, Julie, additional, Dancey, Paul, additional, De Bruycker, Jean-Jacques, additional, Demirkaya, Erkan, additional, Dhalla, Muhammed, additional, Duffy, Ciarán M, additional, Feldman, Brian M, additional, Feldman, Debbie E, additional, Gerschman, Tommy, additional, Haddad, Elie, additional, Heale, Liane, additional, Herrington, Julie, additional, Houghton, Kristin, additional, Huber, Adam M, additional, Human, Andrea, additional, Johnson, Nicole, additional, Jurencak, Roman, additional, Lang, Bianca, additional, Larché, Maggie, additional, Laxer, Ronald M, additional, LeBlanc, Claire M, additional, Lee, Jennifer J Y, additional, Levy, Deborah M, additional, Lim, Lillian, additional, Lim, Lily S H, additional, Luca, Nadia, additional, McGrath, Tara, additional, McMillan, Tamara, additional, Miettunen, Paivi M, additional, Morishita, Kimberly A, additional, Ng, Hon Yan, additional, Oen, Kiem, additional, Park, Jonathan, additional, Petty, Ross E, additional, Proulx-Gauthier, Jean-Philippe, additional, Ramsey, Suzanne, additional, Roth, Johannes, additional, Rosenberg, Alan M, additional, Rozenblyum, Evelyn, additional, Rumsey, Dax G, additional, Schmeling, Heinrike, additional, Schneider, Rayfel, additional, Scuccimarri, Rosie, additional, Shiff, Natalie J, additional, Silverman, Earl, additional, Soon, Gordon, additional, Spiegel, Lynn, additional, Stringer, Elizabeth, additional, Tam, Herman, additional, Tse, Shirley M, additional, Tucker, Lori B, additional, Turvey, Stuart, additional, Twilt, Marinka, additional, Duffy, Karen Watanabe, additional, Yeung, Rae S M, additional, and Guzman, Jaime, additional
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- 2023
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9. Predictive utility of ANCA positivity and antigen specificity in the assessment of kidney disease in paediatric-onset small vessel vasculitis.
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Mann, Simranpreet K., Bone, Jeffrey N., Bosman, Else S., Cabral, David A., Morishita, Kimberly A., and Brown, Kelly L.
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- 2024
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10. Current Approach to the Evaluation and Management of Incomplete Kawasaki Disease in the Emergency Department
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Morishita, Kimberly A. and Goldman, Ran D.
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- 2020
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11. Complexity in unclassified auto-inflammatory disease: a case report illustrating the potential for disease arising from the allelic burden of multiple variants
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Tucker, Lori B., Lamot, Lovro, Niemietz, Iwona, Chung, Brian K., Cabral, David A., Houghton, Kristin, Petty, Ross E., Morishita, Kimberly A., Rice, Gillian I., Turvey, Stuart E., Gibson, William T., and Brown, Kelly L.
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- 2019
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12. Therapeutic Management of Pediatric Antineutrophil Cytoplasmic Antibody (ANCA)-Associated Vasculitis
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Morishita, Kimberly A., Tiller, Georgina, and Cabral, David A.
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- 2017
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13. Contributors
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Aggarwal, Rohit, Ahn, Christine S., Anderson, Meghan, Andrade, Felipe, Appleton, C. Thomas, Ardoin, Stacy P., Ayaz, Nuray Aktay, Baker, Joshua F., Balboni, Imelda, Barbhaiya, Medha, Barbour, Kamil E., Barton, Anne, Baughman, Robert P., Behrens, Edward M., Bermas, Bonnie L., Bertsias, George, Bewtra, Meenakshi, Bhardwaj, Nina, Bieber, Amir, Bingham, Clifton O., III, Blackler, Garth B., Bober, Michael B., Bockenstedt, Linda K., Boilard, Eric, Boin, Francesco, Boumpas, Dimitrios T., Broderick, Lori, Brown, Matthew, Buckley, Christopher D., Budd, Ralph C., Burstein, Sumner, Butler, Andrew J., Canna, Scott W., Cannella, Amy C., Cappelli, Laura C., Carpintero, Maria F., Carter, John D., Chan, Andrew C., Chang, Christopher, Cheng, Joseph, Chiodo, Christopher P., Chowdhary, Vaidehi R., Chung, Sharon A., Cohen, Stanley Bruce, Cook, Paul P., Costello, Kerry E., Cowley, Sharon, Crispín, José C., Crofford, Leslie J., Cronstein, Bruce, Crow, Mary K., Cunnane, Gaye, Daien, Claire I., Dalbeth, Nicola, Dall’Era, Maria, Darrah, Erika, Davis, John M., III, de Almeida, Pedro H.T.Q., De Bari, Cosimo, Eduardo de Barros Branco, Carlos, De Craemer, Ann-Sophie, Dell’Accio, Francesco, DeMarco, Paul J., De Ponti, Federico F., DeQuattro, Kimberly A., Diamond, Betty, Diekhoff, Torsten, di Matteo, Andrea, Distler, Jörg H.W., Dixit, Rajiv, Donohue, Kenneth W., Elewaut, Dirk, El-Gabalawy, Hani S., England, Bryant R., Erkan, Doruk, Eyre, Stephen, Falasinnu, Titilola, Fanouriakis, Antonis C., Fearon, Ursula, Filer, Andrew, Fiorentino, David F., Firestein, Gary S., Fischer, Saloumeh K., Fishman, Felicity G., Fitzgerald, Gillian, Flaherty, John P., Friedman, Marcia, Galli, Stephen J., Gasque, Philippe, Gensler, Lianne S., George, Michael D., Gershwin, M. Eric, Gerstbacher, Dana, Gilbert, Mileka, Goldring, Mary B., Gonzalez, Yoly, Goodman, Stuart B., Graef, Elizabeth R., Graf, Jonathan, Graham, Gerard, Greenspan, Adam, Grimaldi, Christine, Guilherme, Luiza, Guillot, Xavier, Guma, Monica, Gupta, Sarthak, Haberman, Rebecca H., Hajj-Ali, Rula A., Helget, Lindsay N., Hellmann, David B., Hoffman, Hal M., Holers, V. Michael, Huddleston, James I., III, Hudson, Alan P., Humphrey, Mary Beth, Hunder, Gene G., Ikdahl, Eirik, Inman, Robert D., Isaacs, John D., Itoh, Yoshifumi, Iwasaki, Laura, Jaremko, Jacob L., Jeffries, Matlock A., Johnson, Tate M., Jordan, Martha S., Jorizzo, Joseph L., Kaplan, Mariana J., Kapoor, Mohit, Karp, David R., Katz, Patricia, Kavanaugh, Arthur, Kerola, Anne, Kerr, Darcy A., Kievit, Corlinda R.E., Kim, Alfred H.J., Kim, Susan, Kissin, Eugene Y., Klein, Michael J., Kono, Dwight H., Koretzky, Gary A., Korsten, Peter, Krakow, Deborah, Kriegel, Martin Alexander, Kuhn, Kristine A., Kumar, Deepak, Kurata-Sato, Izumi, Lachmann, Helen J., Lafeber, Floris P.J.G., Lane, Nancy E., Langford, Carol A., Lauvau, Gregoire, Lebron, Dora A., Lee, Tzielan C., Leverenz, David L., Lewis, Cara L., Liew, Jean W., Lillegraven, Siri, Lindquist, Ingrid, Loeser, Richard F., Lozada, Carlos J., Lundberg, Ingrid E., Mader, Reuven, Malfait, Anne-Marie, Markenson, Joseph A., Mastbergen, Simon C., Matteson, Eric L., Mayer, Adam, McCarthy, Geraldine M., McCarthy, Katharine, McInnes, Iain B., Mehta, Puja, Merkel, Peter A., Mikuls, Ted R., Millar, Neal L., Miller, John B., Mobasheri, Ali, Monach, Paul A., Morishita, Kimberly A., Motley, Benjamin, Mulders-Manders, Catharina M., Murrell, George A.C., Nagaraju, Kanneboyina, Naovarat, Benjamin S., Naraghi, Kamran, Nasser, Rani, Nelson, Amanda E., Neogi, Tuhina, Nickel, Jeffrey, Nigrovic, Peter A., Oatis, Carol A., O’Dell, James R., Ogdie, Alexis, O’Neil, Liam J., Østergaard, Mikkel, Ozen, Seza, Pacifici, Maurizio, Paley, Michael, Panush, Richard S., Peng, Stanford L., Peterson, Erik J., Philpott, Holly T., Pillai, Shiv, Pillinger, Michael H., Plotz, Benjamin H., Polston, Gregory R., Porcelli, Steven A., Powell-Hamilton, Nina, Pratt, Arthur G., Price, Mark D., Rector, Amadeia, Reddy, Virginia, Reveille, John D., Rhee, Rennie L., Ritchlin, Christopher T., Robinson, Philip C., Rockel, Jason S., Rosen, Antony, Rosenbaum, James T., Rosenberg, Andrew E., Rosenthal, Ann K., Ruderman, Eric M., Saag, Kenneth G., Salmon, Jane E., Sammaritano, Lisa R., Sandborg, Christy I., Santora, Arthur C., II, Sattui, Sebastian E., Sawalha, Amr H., Saxena, Mansi, Scanzello, Carla R., Schenk, Simon, Scher, Jose U., Scherlinger, Marc, Schulert, Grant S., Scott, Charlotte L., Sellam, Jérémie, Semb, Anne Grete, Shah, Ami A., Shah, Sameer B., Sharpley, Faye A., Simard, Julia Fridman, Solow, E. Blair, Sparks, Jeffrey A., St. Clair, E. William, Stang, Alexandra T., Stone, John H., Strowd, Lindsay C., Sweiss, Nadera J., Swigart, Carrie R., Szekanecz, Zoltán, Tanner, Stacy, Taylor, Peter C., Taylor, William J., Tedeschi, Sara K., Thanarajasingam, Uma, Theofilopoulos, Argyrios N., Thoma, Louise M., Toprover, Michael, Torok, Kathryn S., Townsend, Michael J., Trouw, Leendert A., Tsai, Mindy, Tsokos, George C., Vabret, Nicolas, Vakil-Gilani, Kiana, van de Sande, Marleen G.H., Van der Laken, Conny J., van der Linden, Sjef, van der Meer, Jos W.M., van Laar, Jacob M., van Vollenhoven, Ronald F., van Vulpen, Lize F.D., Varga, John, Vaseer, Samera, Veale, Douglas J., Wakefield, Richard J., Wallace, Mark S., Walsh, David Andrew, Ward, Samuel R., Werth, Victoria P., Wigley, Fredrick M., Winthrop, Kevin L., Wright, Tracey, Wu, Ying, Yokoyama, Wayne, Zayat, Ahmed S., Zou, Yong-Rui, and Zurier, Robert B.
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- 2025
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14. Trajectories of pain severity in juvenile idiopathic arthritis: results from the Research in Arthritis in Canadian Children Emphasizing Outcomes cohort
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Shiff, Natalie J., Tupper, Susan, Oen, Kiem, Guzman, Jaime, Lim, Hyun, Lee, Chel Hee, Bryce, Rhonda, Huber, Adam M., Boire, Gilles, Dancey, Paul, Feldman, Brian, Laxer, Ronald, Miettunen, Paivi, Schmeling, Heinrike, Watanabe Duffy, Karen, Levy, Deborah M., Turvey, Stuart, Bolaria, Roxana, Bruns, Alessandra, Cabral, David A., Campillo, Sarah, Chédeville, Gaëlle, Feldman, Debbie Ehrmann, Haddad, Elie, Houghton, Kristin, Johnson, Nicole, Jurencak, Roman, Lang, Bianca, Larche, Maggie, Morishita, Kimberly, Ramsey, Suzanne, Roth, Johannes, Schneider, Rayfel, Scuccimarri, Rosie, Spiegel, Lynn, Stringer, Elizabeth, Tse, Shirley M., Yeung, Rae, Duffy, Ciarán M., and Tucker, Lori B.
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- 2018
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15. Granulomatosis with Polyangiitis in Children
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Cabral, David A., primary and Morishita, Kimberly, additional
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- 2016
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16. Antineutrophil Cytoplasmic Antibody Associated Vasculitis
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Cabral, David A., primary and Morishita, Kimberly, additional
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- 2016
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17. Contributors
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Akikusa, Jonathan, primary, Albani, Salvatore, additional, Allen, Roger, additional, Alsaeid, Khaled, additional, Avčin, Tadej, additional, Babyn, Paul S., additional, Bagga, Arvind, additional, Barron, Karyl S., additional, Becker, Mara L., additional, Benseler, Susanne M., additional, Beukelman, Timothy, additional, Brogan, Paul, additional, Brunner, Hermine I., additional, Burgos-Vargas, Rubèn, additional, Buyon, Jill, additional, Cabral, David A., additional, Choo, Sharon, additional, Cimaz, Rolando, additional, Colbert, Robert Allen, additional, Cole, William G., additional, Davidson, Iris, additional, Benedetti, Fabrizio De, additional, Doria, Andrea S., additional, Dressler, Frank, additional, Duffy, Ciarán M., additional, Eleftheriou, Despina, additional, Feldman, Brian M., additional, Ferguson, Polly J., additional, Fuhlbrigge, Robert, additional, Gattorno, Marco, additional, Grom, Alexei A., additional, Hashkes, Philip J., additional, Houghton, Kristin, additional, Huppertz, Hans-Iko, additional, Ilowite, Norman T., additional, Jaeggi, Edgar, additional, Kastner, Daniel L., additional, Kirton, Adam, additional, Klein-Gitelman, Marisa, additional, Kuchta, Gay, additional, Lane, Jerome Charles, additional, Laxer, Ronald M., additional, LeBlanc, Claire, additional, Leeder, Steven J., additional, Legger, G. Elizabeth, additional, Li, Suzanne C., additional, Lindsley, Carol B., additional, Lovell, Dan, additional, Makitie, Outi, additional, Martini, Alberto, additional, Miller, Frederick W., additional, Morishita, Kimberly, additional, Nigrovic, Peter A., additional, Oen, Kiem G., additional, O'Neil, Kathleen M., additional, Ozen, Seza, additional, Pepmueller, Peri H., additional, Petty, Ross E., additional, Pope, Elena, additional, Prahalad, Sampath, additional, Prakken, Berent, additional, Rapoff, Michael, additional, Rider, Lisa G., additional, Rosé, Carlos Daniel, additional, Rosenbaum, James T., additional, Rosenberg, Alan M., additional, Roth, Johannes, additional, Guillermo, Ricardo Alberto, additional, Schneider, Rayfel, additional, Scott, Christiaan, additional, Sherry, David D., additional, Silverman, Earl, additional, Son, Mary Beth, additional, Sundel, Robert P., additional, Thompson, Susan D., additional, Tiedemann, Karin, additional, Tse, Shirley M.L., additional, Tucker, Lori, additional, Uziel, Yosef, additional, van Montfrans, Joris, additional, Vazques-Mellado, Janitzia, additional, Ward, Leanne, additional, Wedderburn, Lucy R., additional, Wouters, Carine, additional, Wright, James, additional, Wulffraat, Nico M., additional, Zemel, Lawrence, additional, and Zulian, Francesco, additional
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- 2016
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18. The risk and nature of flares in juvenile idiopathic arthritis: results from the ReACCh-Out cohort
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Guzman, Jaime, Oen, Kiem, Huber, Adam M, Watanabe Duffy, Karen, Boire, Gilles, Shiff, Natalie, Berard, Roberta A, Levy, Deborah M, Stringer, Elizabeth, Scuccimarri, Rosie, Morishita, Kimberly, Johnson, Nicole, Cabral, David A, Rosenberg, Alan M, Larché, Maggie, Dancey, Paul, Petty, Ross E, Laxer, Ronald M, Silverman, Earl, Miettunen, Paivi, Chetaille, Anne-Laure, Haddad, Elie, Houghton, Kristin, Spiegel, Lynn, Turvey, Stuart E, Schmeling, Heinrike, Lang, Bianca, Ellsworth, Janet, Ramsey, Suzanne E, Bruns, Alessandra, Roth, Johannes, Campillo, Sarah, Benseler, Susanne, Chédeville, Gaëlle, Schneider, Rayfel, Tse, Shirley M L, Bolaria, Roxana, Gross, Katherine, Feldman, Brian, Feldman, Debbie, Cameron, Bonnie, Jurencak, Roman, Dorval, Jean, LeBlanc, Claire, St. Cyr, Claire, Gibbon, Michele, Yeung, Rae S M, Duffy, Ciarán M, and Tucker, Lori B
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- 2016
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19. The outcomes of juvenile idiopathic arthritis in children managed with contemporary treatments: results from the ReACCh-Out cohort
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Guzman, Jaime, Oen, Kiem, Tucker, Lori B, Huber, Adam M, Shiff, Natalie, Boire, Gilles, Scuccimarri, Rosie, Berard, Roberta, Tse, Shirley M L, Morishita, Kimberly, Stringer, Elizabeth, Johnson, Nicole, Levy, Deborah M, Duffy, Karen Watanabe, Cabral, David A, Rosenberg, Alan M, Larché, Maggie, Dancey, Paul, Petty, Ross E, Laxer, Ronald M, Silverman, Earl, Miettunen, Paivi, Chetaille, Anne-Laure, Haddad, Elie, Houghton, Kristin, Spiegel, Lynn, Turvey, Stuart E, Schmeling, Heinrike, Lang, Bianca, Ellsworth, Janet, Ramsey, Suzanne, Bruns, Alessandra, Campillo, Sarah, Benseler, Susanne, Chédeville, Gaëlle, Schneider, Rayfel, Yeung, Rae, Duffy, Ciarán M, Bolaria, Roxana, Gross, Katherine, Feldman, Brian, Feldman, Debbie, Cameron, Bonnie, Jurencak, Roman, Roth, Johannes, Dorval, Jean, LeBlanc, Claire, and St. Cyr, Claire
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- 2015
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20. Development and validation of the Kids Disability Screen for children with juvenile idiopathic arthritis: results from the CAPRI Registry.
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Houghton, Kristin, McPherson, Meghan, Surjanovic, Nikola, Loughin, Thomas, Berard, Roberta, Proulx-Gauthier, Jean-Phillipe, Chédeville, Gaëlle, Rumsey, Dax, Schmeling, Heinrike, Luca, Nadia, Johnson, Nicole, Gerschman, Tommy, Miettunen, Paivi, Tam, Herman, Lim, Lillian, Morishita, Kimberly, Scuccimarri, Rosie, Roth, Johannes, Duffy, Ciaran, and Tucker, Lori
- Subjects
EXPERIMENTAL design ,RESEARCH methodology ,RESEARCH methodology evaluation ,JUVENILE idiopathic arthritis ,REGRESSION analysis ,FUNCTIONAL assessment ,PSYCHOMETRICS ,DESCRIPTIVE statistics ,SENSITIVITY & specificity (Statistics) ,LONGITUDINAL method ,DISEASE complications - Abstract
Objective The aim of this study was to develop and validate a brief disability screen for children with JIA, the Kids Disability Screen (KDS). Methods A total of 216 children enrolled in the Canadian Alliance of Pediatric Rheumatology Investigators (CAPRI) Registry in 2017–2018 formed a development cohort, and 220 children enrolled in 2019–2020 formed a validation cohort. At every clinic visit, parents answered two questions derived from the Childhood Health Assessment Questionnaire (CHAQ): 'Is it hard for your child to run and play BECAUSE OF ARTHRITIS?' ('Hard' 0–10), and 'Does your child usually need help from you or another person BECAUSE OF ARTHRITIS?' ('Help', 0–10). We used 36-fold cross-validation and tested nine different mathematical methods to combine the answers and optimize psychometric properties. The results were confirmed in the validation cohort. Results Expressed as the mean of the two answers, KDS best balanced ease of use and psychometric properties, while a LASSO regression model combining the two answers with other patient characteristics [estimated CHAQ [eCHAQ]) had the highest responsiveness. In the validation cohort, 22.7%, 25.9% and 28.6% of patients had a score of 0 at enrolment for the KDS, eCHAQ and CHAQ, respectively. Responsiveness was 0.67, 0.74 and 0.62, respectively. Sensitivity to detect a CHAQ > 0 was 0.90 and specificity 0.56, KDS detecting some disability in 44% of children with a CHAQ = 0. Conclusion This simple KDS has psychometric properties comparable with those of a full CHAQ and may be used at every clinic visit to identify those children who need a full disability assessment. [ABSTRACT FROM AUTHOR]
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- 2022
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21. 36 - Antineutrophil Cytoplasmic Antibody Associated Vasculitis
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Cabral, David A. and Morishita, Kimberly A.
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- 2021
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22. 32 - Vasculitis and Its Classification
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Cabral, David A., Ozen, Seza, and Morishita, Kimberly A.
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- 2021
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23. Children with systemic autoinflammatory diseases have multiple, mixed ethnicities that reflect regional ethnic diversity
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Tucker, Lori B., primary, Niemietz, Iwona, additional, Mangat, Preet, additional, Belen, Maria, additional, Tekano, Jenny, additional, Cabral, David A., additional, Guzman, Jaime, additional, Houghton, Kristin M., additional, Morishita, Kimberly A., additional, Chan, Mercedes O., additional, Human, Andrea, additional, Sundqvist, Martina, additional, and Brown, Kelly L., additional
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- 2021
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24. Serious musculoskeletal infections in children receiving anti-tumor necrosis factor-α therapy: a case series
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Morishita, Kimberly, Petty, Ross, Cairns, Robyn, Bolaria, Roxana, Cabral, David, and Turvey, Stuart
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- 2010
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25. CHYLOUS PERICARDIAL EFFUSION IN GRANULOMATOSIS WITH POLYANGIITIS
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Larkins, Nicholas, Harris, Kevin C, Morishita, Kimberly, and Matsell, Douglas G
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- 2014
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26. Additional file 1 of Clinical and psychosocial stress factors are associated with decline in physical activity over time in children with juvenile idiopathic arthritis
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Heale, Liane D., Houghton, Kristin M., Rezaei, Elham, Baxter-Jones, Adam D. G., Tupper, Susan M., Muhajarine, Nazeem, Benseler, Susanne M., Boire, Gilles, Cabral, David A., Campillo, Sarah, Chédeville, Gaëlle, Chetaille, Anne-Laure, Dancey, Paul, Duffy, Ciaran, Duffy, Karen Watanabe, Ellsworth, Janet, Guzman, Jaime, Huber, Adam M., Jurencak, Roman, Lang, Bianca, Laxer, Ronald M., Morishita, Kimberly, Oen, Kiem G., Petty, Ross E., Ramsey, Suzanne E., Roth, Johannes, Schneider, Rayfel, Scuccimarri, Rosie, Spiegel, Lynn, Stringer, Elizabeth, Tse, Shirley M. L., Tucker, Lori B., Turvey, Stuart E., Yeung, Rae S. M., and Rosenberg, Alan M.
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Data_FILES - Abstract
Additional file 1.
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- 2021
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27. Predicting Which Children with Juvenile Idiopathic Arthritis Will Not Attain Early Remission with Conventional Treatment: Results from the ReACCh-Out Cohort
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Guzman, Jaime, Henrey, Andrew, Loughin, Thomas, Berard, Roberta A., Shiff, Natalie J., Jurencak, Roman, Huber, Adam M., Oen, Kiem, Gerhold, Kerstin, Feldman, Brian M., Scuccimarri, Rosie, Houghton, Kristin, Chédeville, Gaëlle, Morishita, Kimberly, Lang, Bianca, Dancey, Paul, Rosenberg, Alan M., Barsalou, Julie, Bruns, Alessandra, Duffy, Karen Watanabe, Benseler, Susanne, Duffy, Ciaran M., Tucker, Lori B., Bolaria, Roxana, Gross, Katherine, Turvey, Stuart E., Cabral, David, Petty, Ross, and Ellsworth, Janet
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Male ,Pediatrics ,medicine.medical_specialty ,Adolescent ,Immunology ,Arthritis ,Early remission ,Logistic regression ,Severity of Illness Index ,Decile ,03 medical and health sciences ,0302 clinical medicine ,Rheumatology ,medicine ,Humans ,Immunology and Allergy ,Juvenile ,Treatment Failure ,030212 general & internal medicine ,Child ,Risk stratification ,030203 arthritis & rheumatology ,Biological Products ,business.industry ,Remission Induction ,Conventional treatment ,Juvenile idiopathic arthritis ,Prognosis ,medicine.disease ,Arthritis, Juvenile ,Logistic Models ,Treatment Outcome ,Antirheumatic Agents ,Child, Preschool ,Cohort ,Cohort studies ,Female ,Prediction ,business ,Cohort study - Abstract
Objective.To estimate the probability of early remission with conventional treatment for each child with juvenile idiopathic arthritis (JIA). Children with a low chance of remission may be candidates for initial treatment with biologics or triple disease-modifying antirheumatic drugs (DMARD).Methods.We used data from 1074 subjects in the Research in Arthritis in Canadian Children emphasizing Outcomes (ReACCh-Out) cohort. The predicted outcome was clinically inactive disease for ≥ 6 months starting within 1 year of JIA diagnosis in patients who did not receive early biologic agents or triple DMARD. Models were developed in 200 random splits of 75% of the cohort and tested on the remaining 25% of subjects, calculating expected and observed frequencies of remission and c-index values.Results.Our best Cox logistic model combining 18 clinical variables a median of 2 days after diagnosis had a c-index of 0.69 (95% CI 0.67–0.71), better than using JIA category alone (0.59, 95% CI 0.56–0.63). Children in the lowest probability decile had a 20% chance of remission and 21% attained remission; children in the highest decile had a 69% chance of remission and 73% attained remission. Compared to 5% of subjects identified by JIA category alone, the model identified 14% of subjects as low chance of remission (probability < 0.25), of whom 77% failed to attain remission.Conclusion.Although the model did not meet our a priori performance threshold (c-index > 0.70), it identified 3 times more subjects with low chance of remission than did JIA category alone, and it may serve as a benchmark for assessing value added by future laboratory/imaging biomarkers.
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- 2019
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28. Wide variation in glucocorticoid dosing in paediatric ANCA-associated vasculitis with renal disease: a paediatric vasculitis initiative study
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Chen, Audrea, primary, Mammen, Cherry, additional, Guzman, Jaime, additional, Al-Abadi, Eslam, additional, Benseler, Susanne M., additional, Berard, Roberta A., additional, Gerstbacher, Dana, additional, Heshin-Bekenstein, Merav, additional, Kim, Susan, additional, Klein-Gitelman, Marisa, additional, Chavan, Pallavi Pimpale, additional, James, Karen E., additional, Martin, Neil, additional, McErlane, Flora, additional, Myrup, Charlotte, additional, Noone, Damien G., additional, Raghuram, Jyothi, additional, Shenoi, Susan, additional, Sivaraman, Vidya, additional, Tanner, Tamara, additional, Yeung, Rae S.M., additional, Cabral, David A., additional, and Morishita, Kimberly A., additional
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- 2021
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29. Impact of the COVID-19 pandemic on juvenile idiopathic arthritis presentation and research recruitment: results from the CAPRI registry.
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Dushnicky, Molly J, Campbell, Catherine, Beattie, Karen A, Berard, Roberta, Cellucci, Tania, Chan, Mercedes, Gerschman, Tommy, Johnson, Nicole, Lim, Lillian, Luca, Nadia, Miettunen, Paivi, Morishita, Kimberly A, Proulx-Gauthier, Jean-Philippe, Rumsey, Dax G, Schmeling, Heinrike, Scuccimarri, Rosie, Tam, Herman, Guzman, Jaime, Batthish, Michelle, and Investigators, for the CAPRI Registry
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HUMAN research subjects ,PATIENT selection ,JUVENILE idiopathic arthritis ,MEDICAL care ,COMPARATIVE studies ,TREATMENT effectiveness ,DESCRIPTIVE statistics ,QUALITY of life ,COVID-19 pandemic ,MEDICAL research - Abstract
Objective The COVID-19 pandemic has disrupted healthcare delivery and clinical research worldwide, with data from areas most affected demonstrating an impact on rheumatology care. This study aimed to characterize the impact of the pandemic on the initial presentation of JIA and JIA-related research in Canada. Methods Data collected from the Canadian Alliance of Pediatric Rheumatology Investigators JIA Registry from the year pre-pandemic (11 March 2019 to 10 March 2020) was compared with data collected during the first year of the pandemic (11 March 2020 to 10 March 2021). Outcomes included time from symptom onset to first assessment, disease severity at presentation and registry recruitment. Proportions and medians were used to describe categorical and continuous variables, respectively. Results The median time from symptom onset to first assessment was 138 (IQR 64–365) days pre-pandemic vs 146 (IQR 83–359) days during the pandemic. The JIA category frequencies remained overall stable (44% oligoarticular JIA pre-pandemic, 46.8% pandemic), except for systemic JIA (12 cases pre-pandemic, 1 pandemic). Clinical features, disease activity (cJADAS10), disability (CHAQ) and quality of life (JAQQ) scores were similar between the two cohorts. Pre-pandemic, 225 patients were enrolled, compared with 111 in the pandemic year, with the greatest decrease from March to June 2020. Conclusions We did not observe the anticipated delay in time to presentation or increased severity at presentation, suggesting that, within Canada, care adapted well to provide support to new patient consults without negative impacts. The COVID-19 pandemic was associated with an initial 50% decrease in registry enrolment but has since improved. [ABSTRACT FROM AUTHOR]
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- 2022
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30. Clinical and Psychosocial Stress Factors are Associated with Decline in Physical Activity Over Time in Children with Juvenile Idiopathic Arthritis
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Heale, Liane D, primary, Houghton, Kristin, additional, Rezaei, Elham, additional, Baxter-Jones, Adam D.G., additional, Tupper, Susan M, additional, Muhajarine, Nazeem, additional, Benseler, Susanne M, additional, Boire, Gilles, additional, Cabral, David A, additional, Campillo, Sarah, additional, Chedeville, Gaelle, additional, Chetaille, Anne-Laure, additional, Dancey, Paul, additional, Duffy, Ciaran, additional, Duffy, Karen Watanabe, additional, Ellsworth, Janet, additional, Guzman, Jaime, additional, Huber, Adam M, additional, Jurencak, Roman, additional, Lang, Bianca, additional, Laxer, Ronald M, additional, Morishita, Kimberly, additional, Oen, Keim G, additional, Petty, Ross E, additional, Ramsey, Suzanne E, additional, Roth, Johannes, additional, Schneider, Rayfel, additional, Scuccimarri, Rosie, additional, Spiegel, Lynn, additional, Stringer, Elizabeth, additional, Tse, Shirley M.L., additional, Tucker, Lori B, additional, Turvey, Stuart E, additional, Yeung, Rae S.M., additional, and Rosenberg, Alan M, additional
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- 2021
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31. Musculoskeletal manifestations of mucopolysaccharidoses
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Morishita, Kimberly and Petty, Ross E.
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- 2011
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32. Mortality in Wegener’s granulomatosis: a bimodal pattern
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Luqmani, Raashid, Suppiah, Ravi, Edwards, Christopher J., Phillip, Rhodri, Maskell, Joe, Culliford, David, Jayne, David, Morishita, Kimberly, and Arden, Nigel
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- 2011
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33. Long-term outcomes and disease course of children with juvenile idiopathic arthritis in the ReACCh-Out cohort: a two-centre experience
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Chhabra, Amieleena, primary, Robinson, Cal, additional, Houghton, Kristin, additional, Cabral, David A, additional, Morishita, Kimberly, additional, Tucker, Lori B, additional, Petty, Ross E, additional, Larché, Maggie, additional, Batthish, Michelle, additional, and Guzman, Jaime, additional
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- 2020
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34. Utility of Adult-Derived Biomarkers for Assessment of Kidney Function in Pediatric ANCA-Associated Vasculitis
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Brown, Kelly, Mann, Simranpreet Kaur, Toor, Kirandeep, Bosman, Else S., Chen, Audrea, Mammen, Cherry, Cabral, David A., and Morishita, Kimberly
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- 2024
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35. Mixed phenotype in a case of an undefined autoinflammatory syndrome
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Niemetz, Iwona, Lamot, Lovro, Tucker, Lori B, Rivera, Angelina, Houghton, Kristin, Guzman, Jaimme, Cabral, David, Morishita, Kimberly, Human, Andrea, and Brown, Kelly L
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Autoinflammatory syndrome - Abstract
Mixed phenotype in a case of an undefined autoinflammatory syndrome
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- 2019
36. The Challenges of Genetic Testing in Children with Suspected Periodic Fever Syndromes
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Lamot, Lovro, Tucker, Lori B, Rivera, Angelina, Houghton, Kristin, Guzman, Jaimme, Cabral, David, Morishita, Kimberly, Human, Andrea, and Brown, Kelly L
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Periodic Fever Syndroms - Abstract
Objectives: Establishing a genetic diagnosis in children with periodic fever syndromes can be challenging. Availability of genetic testing is variable, different testing panels are used, and majority of patients have negative testing or a variant of unclear significance (VUS). We describe genetic testing results of a prospective cohort of children with suspected periodic fever syndromes seen in a provincial pediatric Auto-Inflammatory Diseases clinic in British Columbia (BC). Methods: Auto-Inflammatory Diseases clinic was established in 2016 in Rheumatology, BC Children’s Hospital (BCCH), Vancouver, BC. Until September 2018, 94 patients have been evaluated and enrolled in a longitu- dinal registry, collecting clinical and laboratory data. Gene screening for MEFV, MVK, and TNFRSP1A was available at BCCH Molecular Genetics Laboratory (MGL) ; more extensive gene testing was limited, out of-province and funding dependent, done at GeneDX, MNG labs and Hospital for Sick Children (HSC). Summary results of genetic testing performed in BCCH MGL is reported here. Results: Genetic testing was performed in three quarter of patients (71/94). Mean age of tested patients was 8.2 years (IQR 4.9-11.9 years) and 67.6% were female. Out-of-province testing, including whole exome sequencing and gene panels, was performed in 10 patients, while three patients came to the clinic with out-of-country results of the single gene sequencing. Total of 66 patients were tested in BCCH MGL ; MEFV was sequenced in 61, TNFSR1 in 48 and MVK in 45 patients. In those patients, sequencing of MEFV revealed one homozygous (p.Met694Val) and four heterozygous (p.Met694Val, p.Lys695Arg, p.Glu148Gln, p.Val726Ala) pathogenic or likely pathogenic variants in nine patients, two compound heterozygous VUS (Pro369Ser/Arg408Gln and p.Glu148Gln/p.Leu110Pro) in four patients and two heterozygous VUS (p.Val469Ala and p.Glu248Gln) in two patients. The most common pathogenic variants in MEFV gene were p.Glu148Gln and p.Met694Val seen in three patients each. Sequencing of TNFSR1 revealed one heterozygous pathogenic variant (p.Cys72Tyr) in one patient, three heterozygous VUS (p.Arg121Gln, pThr276Ser and p.Leu359=) in five patients and one heterozygous likely benign variant (p.Pro75Leu) in one patient. Finally, sequencing of MVK revealed two compound heterozygous pathogenic variants (p.Trp188/p.val377Ile and p.Val377Ile/p.Arg215Ter) in one patient each and heterozygous VUS (p.Leu308=) in two patients. Conclusion: Pathogenic variants causing three most common autoinflam- matory diseases (FMF, MKD and TRAPS) were discovered in 18.2% of tested patients. Additionally, 19.7% of patients had VUS in associated genes. The majority of patients did not have an identified pathologic variant, although they had clinical symptoms of a periodic fever syndrome.
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- 2019
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37. Clinical and associated inflammatory biomarker features predictive of short-term outcomes in non-systemic juvenile idiopathic arthritis
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Rezaei, Elham, primary, Hogan, Daniel, additional, Trost, Brett, additional, Kusalik, Anthony J, additional, Boire, Gilles, additional, Cabral, David A, additional, Campillo, Sarah, additional, Chédeville, Gaëlle, additional, Chetaille, Anne-Laure, additional, Dancey, Paul, additional, Duffy, Ciaran, additional, Watanabe Duffy, Karen, additional, Gordon, John, additional, Guzman, Jaime, additional, Houghton, Kristin, additional, Huber, Adam M, additional, Jurencak, Roman, additional, Lang, Bianca, additional, Morishita, Kimberly, additional, Oen, Kiem G, additional, Petty, Ross E, additional, Ramsey, Suzanne E, additional, Scuccimarri, Rosie, additional, Spiegel, Lynn, additional, Stringer, Elizabeth, additional, Taylor-Gjevre, Regina M, additional, Tse, Shirley M L, additional, Tucker, Lori B, additional, Turvey, Stuart E, additional, Tupper, Susan, additional, Yeung, Rae S M, additional, Benseler, Susanne, additional, Ellsworth, Janet, additional, Guillet, Chantal, additional, Karananayake, Chandima, additional, Muhajarine, Nazeem, additional, Roth, Johannes, additional, Schneider, Rayfel, additional, and Rosenberg, Alan M, additional
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- 2020
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38. Feasibility and safety of a 6-month exercise program to increase bone and muscle strength in children with juvenile idiopathic arthritis
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Houghton, Kristin M., Macdonald, Heather M., McKay, Heather A., Guzman, Jaime, Duffy, Ciarán, Tucker, Lori, Berard, Roberta, Boire, Gilles, Bruns, Alessandra, Campillo, Sarah, Chédeville, Gaëlle, Dancey, Paul, Ellsworth, Janet, Feldman, Debbie, Huber, Adam, Johnson, Nicole, Jurencak, Roman, Leblanc, Claire, Levy, Deborah, Miettunen, Paivi, Morishita, Kimberly, Ramsey, Suzanne, Rosenberg, Alan, Roth, Johannes, Rumsey, Dax, Schmeling, Heinrike, Scuccimarri, Rosie, Shiff, Natalie, and Stringer, Elizabeth
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Male ,lcsh:Diseases of the musculoskeletal system ,Childhood arthritis ,Arthritis ,Radius bone ,Cohort Studies ,0302 clinical medicine ,Absorptiometry, Photon ,Quality of life ,Bone Density ,Immunology and Allergy ,030212 general & internal medicine ,Longitudinal Studies ,Quantitative computed tomography ,Child ,medicine.diagnostic_test ,lcsh:RJ1-570 ,Exercise Therapy ,medicine.anatomical_structure ,Treatment Outcome ,Muscle ,Female ,medicine.symptom ,Exercise prescription ,Research Article ,medicine.medical_specialty ,Canada ,Adolescent ,Juvenile arthritis ,03 medical and health sciences ,Rheumatology ,Internal medicine ,medicine ,Humans ,Muscle Strength ,Bone ,Exercise ,030203 arthritis & rheumatology ,business.industry ,Physical activity ,Muscle weakness ,lcsh:Pediatrics ,medicine.disease ,Arthritis, Juvenile ,Pediatrics, Perinatology and Child Health ,Physical therapy ,Quality of Life ,Feasibility Studies ,Patient Compliance ,lcsh:RC925-935 ,business ,Tomography, X-Ray Computed - Abstract
Background Arthritis in childhood can be associated with muscle weakness around affected joints, low bone mass and low bone strength. Exercise is recognized as an important part of management of children with juvenile idiopathic arthritis (JIA) but the exercise prescription to best promote bone and muscle health is unknown. We therefore aimed to: 1. assess feasibility and safety of a 6-month home- and group-based exercise program for children with JIA; 2. estimate the effect of program participation on bone mass and strength, muscle function and clinical outcomes and 3. determine if any positive changes in bone and muscle outcomes are maintained 6 months later. Methods We recruited 24 children with JIA who were part of the Linking Exercise, Physical Activity and Pathophysiology in Childhood Arthritis (LEAP) study to participate in a 6-month home-based exercise program involving jumping and handgrip exercises, resistance training and one group exercise session per month. We assessed lumbar spine bone mass (dual energy X-ray absorptiometry), distal tibia and radius bone microarchitecture and strength (high-resolution peripheral quantitative computed tomography), muscle function (jumping mechanography, dynamometry) and clinical outcomes (joint assessment, function, health-related quality of life) at baseline, 6- and 12-months. Adherence was assessed using weekly activity logs. Results Thirteen children completed the 6-month intervention. Participants reported 9 adverse events and post-exercise pain was rare (0.4%). Fatigue improved, but there were no other sustained improvements in muscle, bone or clinical outcomes. Adherence to the exercise program was low (47%) and decreased over time. Conclusion Children with JIA safely participated in a home-based exercise program designed to enhance muscle and bone strength. Fatigue improved, which may in turn facilitate physical activity participation. Prescribed exercise posed adherence challenges and efforts are needed to address facilitators and barriers to participation in and adherence to exercise programs among children with JIA. Trial registration Data of the children with JIA are from the LEAP study (Canadian Institutes of Health Research (CIHR; GRANT# 107535). http://www.leapjia.com/ Electronic supplementary material The online version of this article (10.1186/s12969-018-0283-4) contains supplementary material, which is available to authorized users.
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- 2018
39. Familial Takayasu arteritis - a pediatric case and a review of the literature
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Brogan Paul A, Rosendahl Karen, and Morishita Kimberly A
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Pediatrics ,RJ1-570 ,Diseases of the musculoskeletal system ,RC925-935 - Abstract
Abstract Takayasu arteritis (TA) is a rare chronic inflammatory disease of the aorta and its major branches. It is seen predominantly in females during the second and third decades of life, although it can occur in childhood. The aetiology of TA remains unknown. To date, familial cases of TA have been considered rare; however, a review of the literature suggests that cases are accumulating. We report a case of two sisters affected by severe TA, and review other reported familial cases.
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- 2011
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40. Soluble Low-density Lipoprotein Receptor-related Protein 1 in Juvenile Idiopathic Arthritis.
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Rezaei, Elham, Newkirk, Marianna M., Zhenhong Li, Gordon, John R., Oen, Kiem G., Benseler, Susanne M., Boire, Gilles, Cabral, David A., Campillo, Sarah, Chédeville, Gaëlle, Chetaille, Anne-Laure, Dancey, Paul, Duffy, Ciaran, Watanabe Duffy, Karen, Houghton, Kristin, Huber, Adam M., Jurencak, Roman, Lang, Bianca, Morishita, Kimberly A., and Petty, Ross E.
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- 2021
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41. The importance of considering monogenic causes of autoimmunity: A somatic mutation in KRAS causing pediatric Rosai-Dorfman syndrome and systemic lupus erythematosus
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Ragotte, Robert J., Dhanrajani, Anita, Pleydell-Pearce, Julian, Del Bel, Kate L., Tarailo-Graovac, Maja, van Karnebeek, Clara, Terry, Jefferson, Senger, Christof, McKinnon, Margaret L., Seear, Michael, Prendiville, Julie S., Tucker, Lori B., Houghton, Kristin, Cabral, David A., Guzman, Jaime, Petty, Ross E., Brown, Kelly L., Tekano, Jenny, Wu, John, Morishita, Kimberly A., and Turvey, Stuart E.
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- 2017
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42. Early Outcomes in Children with Antineutrophil Cytoplasmic Antibody (ANCA) Associated Vasculitis (AAV)
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Morishita, Kimberly, Moorthy, Lakshmi N., Lubieniecka, Joanna M., Twilt, Marinka, Yeung, Rae S.M., Toth, Mary B., Shenoi, Susan, Ristic, Goran, Nielsen, Susan M., Li, Suzanne C., Lee, Tzielan, Lawson, Erica, Kostik, Mikhail, Klein-Gitelman, Marisa, Huber, Adam M., Hersh, Aimee O., Foell, Dirk, Elder, Melissa E., Eberhard, Barbara A., Dancey, Paul, Charuvanij, Sirirat, Benseler, Susanne, and Cabral, David
- Abstract
Objective: To characterize early disease course in childhood onset antineutrophil cytoplasmic antibody (ANCA) associated vasculitis (AAV) and 12-month outcomes. Methods: Eligible subjects were children diagnosed with GPA, MPA, EGPA, and ANCA-positive pauci-immune glomerulonephritis before their eighteenth birthday and entered into The Pediatric Vasculitis Initiative (PedVas) study. The primary outcome was remission (Pediatric Vasculitis Activity Score (PVAS) = 0 with corticosteroid dose (CS)
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- 2018
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43. Health-Related Quality of Life in an Inception Cohort of Children With Juvenile Idiopathic Arthritis: A Longitudinal Analysis
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Oen, Kiem, Guzman, Jaime, Dufault, Brenden, Tucker, Lori B, Shiff, Natalie J, Duffy, Karen Watanabe, Lee, Jennifer J Y, Feldman, Brian M, Berard, Roberta A, Dancey, Paul, Huber, Adam M, Scuccimarri, Rosie, Cabral, David A, Morishita, Kimberly A, Ramsey, Suzanne E, Rosenberg, Alan M, Boire, Gilles, Benseler, Susanne M, Lang, Bianca, Houghton, Kristin, Miettunen, Paivi M, Chédeville, Gaëlle, Levy, Deborah M, Bruns, Alessandra, Schmeling, Heinrike, Haddad, Elie, Yeung, Rae S M, Duffy, Ciarán M, and The Research in Arthritis in Canadian Children emphasizing Outcomes (ReACCh-Out) investigators
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Male ,Pediatrics ,Time Factors ,Arthritis ,Child Behavior ,Disability Evaluation ,0302 clinical medicine ,Child Development ,Quality of life ,Surveys and Questionnaires ,Medicine ,longitudinal studies ,Longitudinal Studies ,030212 general & internal medicine ,Child ,Pain Measurement ,Oligoarthritis ,adolescent development ,Age Factors ,Prognosis ,humanities ,female ,arthritis ,Predictive value of tests ,Child, Preschool ,Cohort ,Female ,Polyarthritis ,medicine.medical_specialty ,age factors ,Canada ,Adolescent ,disability evaluation ,adolescent behavior ,pain measurement ,preschool ,03 medical and health sciences ,Rheumatology ,Predictive Value of Tests ,Humans ,Survival analysis ,030203 arthritis & rheumatology ,business.industry ,Adolescent Development ,medicine.disease ,Child development ,Arthritis, Juvenile ,juvenile ,quality of life ,Adolescent Behavior ,Quality of Life ,business - Abstract
Objective To describe changes in health-related quality of life (HRQoL) over time in children with juvenile idiopathic arthritis (JIA), relative to other outcomes, and to identify predictors of unfavorable HRQoL trajectories. Methods Children with JIA in the Research in Arthritis in Canadian Children emphasizing Outcomes (ReACCh-Out) cohort were included. The Juvenile Arthritis Quality of Life Questionnaire (JAQQ, a standardized instrument), health-related Quality of My Life (HRQoML, an instrument based on personal valuations), and JIA core variables were completed serially. Analyses included median values, Kaplan-Meier survival curves, and latent trajectory analysis. Results A total of 1,249 patients enrolled at a median of 0.5 months after diagnosis were followed for a median of 34.2 months. The degree of initial HRQoL impairment and probabilities of reaching the best possible HRQoL scores varied across JIA categories (best for oligoarthritis, worst for rheumatoid factor–positive polyarthritis). Median times to attain best possible HRQoL scores (JAQQ 59.3 months, HRQoML 34.5 months), lagged behind those for disease activity, pain, and disability measures. Most patients followed trajectories with minimal or mild impairment; however, 7.6% and 13.8% of patients, respectively, followed JAQQ and HRQoML trajectories with persistent major impairment in HRQoL. JIA category, aboriginal ethnicity, and baseline disease activity measures distinguished between membership in trajectories with major and minimal impairments. Conclusion Improvement in HRQoL is slower than for disease activity, pain, and disability. Improvement of a measure based on respondents’ preferences (HRQoML) is more rapid than that of a standardized measure (JAQQ). Higher disease activity at diagnosis heralds an unfavorable HRQoL trajectory.
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- 2018
44. Different Disease Endotypes in Phenotypically Similar Vasculitides Affecting Small-to-Medium Sized Blood Vessels.
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Gill, Erin E., Smith, Maren L., Gibson, Kristen M., Morishita, Kimberly A., Lee, Amy H. Y., Falsafi, Reza, Graham, Jinko, Foell, Dirk, Benseler, Susanne M., Ross, Colin J., Luqmani, Raashid A., Cabral, David A., Hancock, Robert E. W., and Brown, Kelly L.
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VASCULITIS ,BLOOD vessels ,T cell receptors ,GENES ,DIAGNOSIS - Abstract
Objectives: Chronic primary vasculitis describes a group of complex and rare diseases that are characterized by blood vessel inflammation. Classification of vasculitis subtypes is based predominantly on the size of the involved vessels and clinical phenotype. There is a recognized need to improve classification, especially for small-to-medium sized vessel vasculitides, that, ideally, is based on the underlying biology with a view to informing treatment. Methods: We performed RNA-Seq on blood samples from children (n = 41) and from adults (n = 11) with small-to-medium sized vessel vasculitis, and used unsupervised hierarchical clustering of gene expression patterns in combination with clinical metadata to define disease subtypes. Results: Differential gene expression at the time of diagnosis separated patients into two primary endotypes that differed in the expression of ~3,800 genes in children, and ~1,600 genes in adults. These endotypes were also present during disease flares, and both adult and pediatric endotypes could be discriminated based on the expression of just 20 differentially expressed genes. Endotypes were associated with distinct biological processes, namely neutrophil degranulation and T cell receptor signaling. Conclusions: Phenotypically similar subsets of small-to-medium sized vessel vasculitis may have different mechanistic drivers involving innate vs. adaptive immune processes. Discovery of these differentiating immune features provides a mechanistic-based alternative for subclassification of vasculitis. [ABSTRACT FROM AUTHOR]
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- 2021
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45. Real-World Effectiveness of Common Treatment Strategies for Juvenile Idiopathic Arthritis: Results From a Canadian Cohort.
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Chhabra, Amieleena, Oen, Kiem, Huber, Adam M., Shiff, Natalie J., Boire, Gilles, Benseler, Susanne M., Berard, Roberta A., Scuccimarri, Rosie, Feldman, Brian M., Lim, Lily Siok Hoon, Barsalou, Julie, Bruns, Alessandra, Cabral, David A., Chédeville, Gaëlle, Ellsworth, Janet, Houghton, Kristin, Lang, Bianca, Morishita, Kimberly, Rumsey, Dax G., and Rosenberg, Alan M.
- Abstract
Objective: Undervaluing the effectiveness of conventional treatments may lead to overtreatment with biologic medications in children with juvenile idiopathic arthritis (JIA). Using data from a nationwide inception cohort and strict methods to control bias, the aim of our study was to estimate the real-world effectiveness of simple JIA treatment strategies recommended in current guidelines.Methods: Children with JIA who were recruited at 16 Canadian centers from 2005 to 2010 were followed for up to 5 years. For each child, all observed treatment changes over time were assessed by independent physicians using prospectively collected data and published response criteria. Success was defined as attainment of inactive disease or maintenance of this state when stepping down treatment; minimally active disease was deemed acceptable for children with polyarticular JIA. Success rates were calculated for treatments tried ≥25 times, and logistic regression analysis identified features associated with success.Results: A total of 4,429 treatment episodes were observed in 1,352 children. Nonsteroidal antiinflammatory drug (NSAID) monotherapy was attempted 697 times, mostly as initial treatment when <5 joints were involved, with a 54.4% success rate (95% confidence interval [95% CI] 50.3-58.6). NSAIDs plus joint injections had a 64.7% success rate (95% CI 59.8-69.7). Adding methotrexate to NSAIDs and/or joint injections (attempted 566 times) had a 60.5% success rate (95% CI 55.7-65.3). In adjusted analyses, each additional active joint reduced chances of success for treatment with NSAIDs (odds ratio [OR] 0.90 [95% CI 0.85-0.94]) and for methotrexate combinations (OR 0.96 [95% CI 0.94-0.99]). Each additional year after disease onset reduced chances of success for treatment with methotrexate combinations (OR 0.83 [95% CI 0.72-0.95]).Conclusion: These real-world effectiveness estimates show that conventional nonbiologic treatment strategies that are recommended in current guidelines are effective in achieving treatment targets in many children with JIA. [ABSTRACT FROM AUTHOR]- Published
- 2020
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46. Natural history and extracutaneous involvement of congenital morphea: Multicenter retrospective cohort study and literature review
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Mansour, Mark, primary, Liy Wong, Carmen, additional, Zulian, Francesco, additional, Li, Suzanne, additional, Morishita, Kimberly, additional, Yeh, Eluen Ann, additional, Stewart, Katie, additional, Laxer, Ronald M., additional, and Pope, Elena, additional
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- 2018
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47. Contributors
- Author
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Abinun, Mario, Aggarwal, Amita, Akikusa, Jonathan, Allen, Roger, Alsaeid, Khaled, Avčin, Tadej, Balevic, Stephen, Banwell, Brenda, Barron, Karyl, Barsalou, Julie, Becker, Mara L., Behrens, Edward M., Beresford, Michael W., Beukelman, Timothy, Bockenstedt, Linda K., Brogan, Paul, Brunner, Hermine I., Burns, Jane C., Busch, Robert, Cabral, David A., Canna, Scott W., Choo, Sharon, Cimaz, Rolando, Ciurtin, Coziana, Clinch, Jacqui, Colbert, Robert A., Consolaro, Alessandro, Cooper, Jennifer C., Cron, Randy Q., Davidson, Iris, Dusser, Perrine, Eleftheriou, Despina, Feldman, Brian Michael, Ferguson, Polly J., Foster, Helen Elisabeth, Fuhlbrigge, Robert C., Funk, Ryan S., Gattorno, Marco, Giancane, Gabriella, Griffiths, Anne, Grom, Alexei A., Harel, Liora, Hashkes, Philip J., Hedrich, Christian Michael, Horneff, Gerd, Houghton, Kristin Michelle, Jaeggi, Edgar, Jariwala, Mehul, Jones, Jordan T., Kastner, Daniel L., Kimura, Yukiko, Klein-Gitelman, Marisa S., Koné-Paut, Isabelle, Laxer, Ronald M., Anne LeBlanc, Claire Marie, Li, Suzanne C., Lindsley, Carol B., Martini, Alberto, Mellins, Elizabeth, Morishita, Kimberly A., Muscal, Eyal, Newburger, Jane W., Nigrovic, Peter A., Nott, Kerstin A., O’Neil, Kathleen M., Ombrello, Michael J., Orme, Lisa, Ozen, Seza, Petty, Ross E., Pilkington, Clarissa A., Pope, Elena, Prahalad, Sampath, Prescott, Steven A., Pääkkönen, Markus, Rabinovich, C. Egla, Ramanan, Athimalaipet V., Ravelli, Angelo, Ricciuto, Amanda, Ringold, Sarah, Rosenbaum, James Todd, Rosenberg, Alan M., Rosendahl, Karen, Rosser, Elizabeth C., Rosé, Carlos Daniel, Roth, Johannes, Ruperto, Nicolino, Schulert, Grant, Scott, Christiaan, Sen, Ethan S., Sherry, David D., Silverman, Earl D., Son, Mary Beth F., Sontichai, Watchareewan, Stevens, Anne M., Stinson, Jennifer N., Stoll, Matthew L., Sullivan, Kathleen, Takken, Tim, Torok, Kathryn S., Tse, Shirley M.L., Tucker, Lori, Unger, Sheila, Uziel, Yosef, van der Net, Janjaap, Vastert, Sebastiaan J., Ward, Leanne M., Wedderburn, Lucy R., Weiss, Pamela F., Wouters, Carine Helena, and Zemel, Lawrence
- Published
- 2021
- Full Text
- View/download PDF
48. Chapter 36 - Antineutrophil Cytoplasmic Antibody Associated Vasculitis
- Author
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Cabral, David A. and Morishita, Kimberly
- Published
- 2016
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49. Additional file 1: of Growth and weight gain in children with juvenile idiopathic arthritis: results from the ReACCh-Out cohort
- Author
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Guzman, Jaime, Kerr, Tristan, Ward, Leanne, Jinhui Ma, Kiem Oen, Rosenberg, Alan, Feldman, Brian, Boire, Gilles, Houghton, Kristin, Dancey, Paul, Scuccimarri, Rosie, Bruns, Alessandra, Huber, Adam, Duffy, Karen Watanabe, Shiff, Natalie, Berard, Roberta, Levy, Deborah, Stringer, Elizabeth, Morishita, Kimberly, Johnson, Nicole, Cabral, David, LarchĂŠ, Maggie, Petty, Ross, Laxer, Ronald, Silverman, Earl, Paivi Miettunen, Anne-Laure Chetaille, Haddad, Elie, Spiegel, Lynn, Turvey, Stuart, Schmeling, Heinrike, Lang, Bianca, Ellsworth, Janet, Ramsey, Suzanne, Roth, Johannes, Campillo, Sarah, Benseler, Susanne, GaĂŤlle ChĂŠdeville, Rayfel Schneider, Tse, Shirley, Bolaria, Roxana, Gross, Katherine, Feldman, Debbie, Cameron, Bonnie, Jurencak, Roman, Dorval, Jean, LeBlanc, Claire, Cyr, Claire St., Gibbon, Michele, Yeung, Rae, CiarĂĄn Duffy, and Tucker, Lori
- Abstract
Growth and Weight Gain in Juvenile Arthritis. (DOCX 2958 kb)
- Published
- 2017
- Full Text
- View/download PDF
50. Trajectories of pain severity in juvenile idiopathic arthritis: results from the Research in Arthritis in Canadian Children Emphasizing Outcomes cohort
- Author
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Shiff, Natalie J., primary, Tupper, Susan, additional, Oen, Kiem, additional, Guzman, Jaime, additional, Lim, Hyun, additional, Lee, Chel Hee, additional, Bryce, Rhonda, additional, Huber, Adam M., additional, Boire, Gilles, additional, Dancey, Paul, additional, Feldman, Brian, additional, Laxer, Ronald, additional, Miettunen, Paivi, additional, Schmeling, Heinrike, additional, Watanabe Duffy, Karen, additional, Levy, Deborah M., additional, Turvey, Stuart, additional, Bolaria, Roxana, additional, Bruns, Alessandra, additional, Cabral, David A., additional, Campillo, Sarah, additional, Chédeville, Gaëlle, additional, Feldman, Debbie Ehrmann, additional, Haddad, Elie, additional, Houghton, Kristin, additional, Johnson, Nicole, additional, Jurencak, Roman, additional, Lang, Bianca, additional, Larche, Maggie, additional, Morishita, Kimberly, additional, Ramsey, Suzanne, additional, Roth, Johannes, additional, Schneider, Rayfel, additional, Scuccimarri, Rosie, additional, Spiegel, Lynn, additional, Stringer, Elizabeth, additional, Tse, Shirley M., additional, Yeung, Rae, additional, Duffy, Ciarán M., additional, and Tucker, Lori B., additional
- Published
- 2017
- Full Text
- View/download PDF
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