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249 results on '"Morisson, Mireille"'

3. A New Chicken Genome Assembly Provides Insight into Avian Genome Structure

Author

Warren, Wesley C, Hillier, LaDeana W, Tomlinson, Chad, Minx, Patrick, Kremitzki, Milinn, Graves, Tina, Markovic, Chris, Bouk, Nathan, Pruitt, Kim D, Thibaud-Nissen, Francoise, Schneider, Valerie, Mansour, Tamer A, Brown, C Titus, Zimin, Aleksey, Hawken, Rachel, Abrahamsen, Mitch, Pyrkosz, Alexis B, Morisson, Mireille, Fillon, Valerie, Vignal, Alain, Chow, William, Howe, Kerstin, Fulton, Janet E, Miller, Marcia M, Lovell, Peter, Mello, Claudio V, Wirthlin, Morgan, Mason, Andrew S, Kuo, Richard, Burt, David W, Dodgson, Jerry B, and Cheng, Hans H

Subjects
Biological Sciences, Bioinformatics and Computational Biology, Genetics, Biotechnology, Human Genome, Generic health relevance, Animals, Chickens, Chromosomes, Artificial, Bacterial, Computational Biology, Contig Mapping, Genome, Molecular Sequence Annotation, Sequence Analysis, DNA, Gallus gallus, genome assembly, MHC, Biochemistry and cell biology, Statistics
Abstract

The importance of the Gallus gallus (chicken) as a model organism and agricultural animal merits a continuation of sequence assembly improvement efforts. We present a new version of the chicken genome assembly (Gallus_gallus-5.0; GCA_000002315.3), built from combined long single molecule sequencing technology, finished BACs, and improved physical maps. In overall assembled bases, we see a gain of 183 Mb, including 16.4 Mb in placed chromosomes with a corresponding gain in the percentage of intact repeat elements characterized. Of the 1.21 Gb genome, we include three previously missing autosomes, GGA30, 31, and 33, and improve sequence contig length 10-fold over the previous Gallus_gallus-4.0. Despite the significant base representation improvements made, 138 Mb of sequence is not yet located to chromosomes. When annotated for gene content, Gallus_gallus-5.0 shows an increase of 4679 annotated genes (2768 noncoding and 1911 protein-coding) over those in Gallus_gallus-4.0. We also revisited the question of what genes are missing in the avian lineage, as assessed by the highest quality avian genome assembly to date, and found that a large fraction of the original set of missing genes are still absent in sequenced bird species. Finally, our new data support a detailed map of MHC-B, encompassing two segments: one with a highly stable gene copy number and another in which the gene copy number is highly variable. The chicken model has been a critical resource for many other fields of study, and this new reference assembly will substantially further these efforts.

Published
2017

5. Epigénétique, gènes et environnement : quelle importance pour les pratiques d’élevage et les méthodes de sélection des volailles ?

Author

COUSTHAM, Vincent, primary, ANDRIEUX, Charlotte, additional, CERUTTI, Chloé, additional, COLLIN, Anne, additional, DAVID, Ingrid, additional, DEMARS, Julie, additional, DEVAILLY, Guillaume, additional, MORISSON, Mireille, additional, HOUSSIER, Marianne, additional, LAGARRIGUE, Sandrine, additional, MÉTAYER-COUSTARD, Sonia, additional, MIGNON-GRASTEAU, Sandrine, additional, PANSERAT, Stéphane, additional, PETIT, Angélique, additional, VITORINO CARVALHO, Anaïs, additional, ZERJAL, Tatiana, additional, and PITEL, Frédérique, additional

Published
2023
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8. Fasting/refeeding: an experimental model to study the impact of early thermal manipulation on hepatic metabolism in mule ducks

Author

Andrieux, Charlotte, primary, Marchand, Michaël, additional, Larroquet, Laurence, additional, Veron, Vincent, additional, Biasutti, Sandra, additional, Barrieu, Josette, additional, Morganx, Philippe, additional, Morisson, Mireille, additional, Coustham, Vincent, additional, Panserat, Stéphane, additional, and Houssier, Marianne, additional

Published
2023
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10. Nutritional Programming and Effect of Ancestor Diet in Birds

Author

Morisson, Mireille, primary, Coustham, Vincent, additional, Frésard, Laure, additional, Collin, Anne, additional, Zerjal, Tatiana, additional, Métayer-Coustard, Sonia, additional, Bodin, Loys, additional, Minvielle, Francis, additional, Brun, Jean-Michel, additional, and Pitel, Frédérique, additional

Published
2017
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11. Species difference in ANP32A underlies influenza A virus polymerase host restriction

Author

Long, Jason S., Giotis, Efstathios S., Moncorge, Olivier, Frise, Rebecca, Mistry, Bhakti, James, Joe, Morisson, Mireille, Iqbal, Munir, Vignal, Alain, Skinner, Michael A., and Barclay, Wendy S.

Subjects
Avian influenza -- Research -- Care and treatment -- Complications and side effects, Antiviral agents -- Health aspects -- Research, Environmental issues, Science and technology, Zoology and wildlife conservation
Abstract

Influenza pandemics occur unpredictably when zoonotic influenza viruses with novel antigenicity acquire the ability to transmit amongst humans (1). Host range breaches are limited by incompatibilities between avian virus components and the human host. Barriers include receptor preference, virion stability and poor activity of the avian virus RNA-dependent RNA polymerase in human cells (2). Mutants of the heterotrimeric viral polymerase components, particularly PB2 protein, are selected during mammalian adaptation, but their mode of action is unknown (3-6). We show that a species-specific difference in host protein ANP32A accounts for the suboptimal function of avian virus polymerase in mammalian cells. Avian ANP32A possesses an additional 33 amino acids between the leucine-rich repeats and carboxy-terminal low-complexity acidic region domains. In mammalian cells, avian ANP32A rescued the suboptimal function of avian virus polymerase to levels similar to mammalian-adapted polymerase. Deletion of the avian-specific sequence from chicken ANP32A abrogated this activity, whereas its insertion into human ANP32A, or closely related ANP32B, supported avian virus polymerase function. Substitutions, such as PB2(E627K), were rapidly selected upon infection of humans with avian H5N1 or H7N9 influenza viruses, adapting the viral polymerase for the shorter mammalian ANP32A. Thus ANP32A represents an essential host partner co-opted to support influenza virus replication and is a candidate host target for novel antivirals., The negative sense RNA genome of influenza virus is delivered into host cells associated with the viral RNA-dependent RNA polymerase, a heterotrimeric complex of PB1, PB2 and PA proteins and [...]

Published
2016

12. Application of Metabolomics to Identify Hepatic Biomarkers of Foie Gras Qualities in Duck

Author

Mozduri, Zohre, Lo, Bara, Marty-Gasset, Nathalie, Masoudi, Ali Akbar, Arroyo, Julien, Morisson, Mireille, Canlet, Cécile, Bonnet, Agnès, Bonnefont, Cécile, Tarbiat Modares University [Tehran], Génétique Physiologie et Systèmes d'Elevage (GenPhySE ), Ecole Nationale Vétérinaire de Toulouse (ENVT), Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-École nationale supérieure agronomique de Toulouse [ENSAT]-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Association des Eleveurs de Dordogne (Asseldor), ToxAlim (ToxAlim), Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Ecole Nationale Vétérinaire de Toulouse (ENVT), Université Fédérale Toulouse Midi-Pyrénées-Ecole d'Ingénieurs de Purpan (INPT - EI Purpan), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Metatoul AXIOM (E20 ), MetaboHUB-MetaToul, Génopole Toulouse Midi-Pyrénées [Auzeville] (GENOTOUL), Université Fédérale Toulouse Midi-Pyrénées-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Génopole Toulouse Midi-Pyrénées [Auzeville] (GENOTOUL), Université Fédérale Toulouse Midi-Pyrénées-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-ToxAlim (ToxAlim), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Ecole d'Ingénieurs de Purpan (INPT - EI Purpan), CIFOG, Conseil régional d'Aquitaine, Conseil départemental de Dordogne, Morisson, Mireille, Analyse de Xénobiotiques, Identification, Métabolisme (E20 Metatoul-AXIOM), MetaToul-MetaboHUB, Institut National des Sciences Appliquées - Toulouse (INSA Toulouse), Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Université Toulouse III - Paul Sabatier (UT3), and Université Fédérale Toulouse Midi-Pyrénées-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Institut National des Sciences Appliquées - Toulouse (INSA Toulouse)

Subjects
[SDV] Life Sciences [q-bio], quality, Physiology, [SDV]Life Sciences [q-bio], Physiology (medical), biomarker, foie gras, liver, metabolomics
Abstract

International audience; Foie gras is a traditional dish in France that contains 50 to 60% of lipids. The high-fat content of the liver improves the organoleptic qualities of foie gras and reduces its technological yield at cooking (TY). As the valorization of the liver as foie gras products is strongly influenced by the TY, classifying the foie gras in their potential technological quality before cooking them is the main challenge for producers. Therefore, the current study aimed to identify hepatic biomarkers of foie gras qualities like liver weight (LW) and TY. A group of 120 male mule ducks was reared and overfed for 6-12 days, and their livers were sampled and analyzed by proton nuclear magnetic resonance (1 H-NMR). Eighteen biomarkers of foie gras qualities were identified, nine for LW and TY, five specific to LW, and four specific to TY. All biomarkers were strongly negatively correlated to the liver weights and positively correlated to the technological yield, except for the lactate and the threonine, and also for the creatine that was negatively correlated to foie gras technological quality. As a result, in heavy livers, the liver metabolism was oriented through a reduction of carbohydrate and amino acid metabolisms, and the plasma membrane could be damaged, which may explain the low technological yield of these livers. The detected biomarkers have been strongly discussed with the metabolism of the liver in nonalcoholic steatohepatitis.

Published
2021
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15. A gene-based radiation hybrid map of chicken microchromosome 14: Comparison to human and alignment to the assembled chicken sequence

Author

Milan Denis, Faraut Thomas, Feve Katia, Bardes Suzanne, Lagarrigue Sandrine, Pitel Frédérique, Assaf Sirine, Jiguet-Jiglaire Carine, Leroux Sophie, Morisson Mireille, and Vignal Alain

Subjects
chicken, comparative mapping, radiation hybrids, microchromosome 14, intrachromosomal rearrangement, Animal culture, SF1-1100, Genetics, QH426-470
Abstract

Abstract We present a gene-based RH map of the chicken microchromosome GGA14, known to have synteny conservations with human chromosomal regions HSA16p13.3 and HSA17p11.2. Microsatellite markers from the genetic map were used to check the validity of the RH map and additional markers were developed from chicken EST data to yield comparative mapping data. A high rate of intra-chromosomal rearrangements was detected by comparison to the assembled human sequence. Finally, the alignment of the RH map to the assembled chicken sequence showed a small number of discordances, most of which involved the same region of the chromosome spanning between 40.5 and 75.9 cR6000 on the RH map.

Published
2005
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16. Assignment of CPS1, OTC, CRYD2, ARG2 and ASS genes to the chicken RH map

Author

Vignal Alain, Maeda Yoshizane, Okamoto Shin, Kawabe Kotaro, Morisson Mireille, Bosak Natalia, Shimogiri Takeshi, and Yasue Hiroshi

Subjects
ornithine-urea cycle, chicken, radiation hybrid mapping, chromosomal assignment, Animal culture, SF1-1100, Genetics, QH426-470
Abstract

Abstract An attempt was made to assign five genes, CPS1, OTC, ASS, CRYD2, and ARG2, to chicken chromosomes (GGA) by radiation-hybrid mapping. OTC was assigned to GGA1; ARG2 to GGA5; CPS1 to GGA7; and CRYD2 to GGA19. ASS was not, however, assigned to a specific chromosomal position.

Published
2004
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17. Impacts of Embryonic Thermal Programming on the Expression of Genes Involved in Foie gras Production in Mule Ducks

Author

Massimino, William, primary, Andrieux, Charlotte, additional, Biasutti, Sandra, additional, Davail, Stéphane, additional, Bernadet, Marie-Dominique, additional, Pioche, Tracy, additional, Ricaud, Karine, additional, Gontier, Karine, additional, Morisson, Mireille, additional, Collin, Anne, additional, Panserat, Stéphane, additional, and Houssier, Marianne, additional

Published
2021
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18. ChickRH6: a chicken whole-genome radiation hybrid panel

Author

Yerle Martine, Fillon Valérie, Pitel Frédérique, Fève Katia, Delcros Chantal, Pinton Philippe, Plisson-Petit Florence, Galan Maxime, Bosc Sarah, Lemière Alexandre, Morisson Mireille, and Vignal Alain

Subjects
chicken, radiation hybrid, mapping, Animal culture, SF1-1100, Genetics, QH426-470
Abstract

Abstract As a first step towards the development of radiation hybrid maps, we have produced a radiation hybrid panel in the chicken by fusing female embryonic diploid fibroblasts irradiated at 6 000 rads with HPRT-deficient hamster Wg3hCl2 cells. Due to the low retention frequency of the chicken fragments, a high number of clones was produced from which the best ones were selected. Thus, 452 fusion clones were tested for retention frequencies with a panel of 46 markers. Based on these results, 103 clones with a mean marker retention of 23.8% were selected for large scale culture to produce DNA in sufficient quantities for the genotyping of numerous markers. Retention frequency was tested again with the same 46 markers and the 90 best clones, with a final mean retention frequency of 21.9%, were selected for the final panel. This panel will be a valuable resource for fine mapping of markers and genes in the chicken, and will also help in building BAC contigs.

Published
2002
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19. Identification of Plasmatic Biomarkers of Foie Gras Qualities in Duck by Metabolomics

Author

Masoudi, Ali Akbar, Mozduri, Zohre, Marty-Gasset, Nathalie, Lo, Bara, Masoudi, Ali, Morisson, Mireille, Canlet, Cécile, Arroyo, Julien, Bonnet, Agnès, bonnefont, Cécile, Tarbiat Modares University [Tehran], Génétique Physiologie et Systèmes d'Elevage (GenPhySE ), Ecole Nationale Vétérinaire de Toulouse (ENVT), Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-École nationale supérieure agronomique de Toulouse [ENSAT]-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Analyse de Xénobiotiques, Identification, Métabolisme (E20 Metatoul-AXIOM), MetaToul-MetaboHUB, Génopole Toulouse Midi-Pyrénées [Auzeville] (GENOTOUL), Institut National des Sciences Appliquées - Toulouse (INSA Toulouse), Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Ecole Nationale Vétérinaire de Toulouse (ENVT), Université Fédérale Toulouse Midi-Pyrénées-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Institut National des Sciences Appliquées - Toulouse (INSA Toulouse), Université Fédérale Toulouse Midi-Pyrénées-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Génopole Toulouse Midi-Pyrénées [Auzeville] (GENOTOUL), Université Fédérale Toulouse Midi-Pyrénées-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-ToxAlim (ToxAlim), Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Ecole d'Ingénieurs de Purpan (INPT - EI Purpan), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Ecole d'Ingénieurs de Purpan (INPT - EI Purpan), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Association des Eleveurs de Dordogne (Asseldor), Interprofession Foie gras (CIFOG), and Aquitaine Regional and Dordogne Departmental Councils for funding the project, and Université Fédérale Toulouse Midi-Pyrénées-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Université Toulouse III - Paul Sabatier (UT3)

Subjects
quality, [SDV]Life Sciences [q-bio], biomarker, foie gras, liver, metabolomics, [SDV.AEN]Life Sciences [q-bio]/Food and Nutrition, plasma
Abstract

International audience; The foie gras is an emblematic product of French gastronomy composed of waterfowl fatty liver. The organoleptic qualities of this product depend on the liver characteristics such as liver weight (LW) and technological yield (TY) at cooking. One of the main issues for producers is to classify the foie gras with high or low technological quality before cooking them. Thus the study aims at identifying biomarkers of these characteristics with non-invasive biomarkers in duck. 1H-NMR (nuclear magnetic resonance of the proton) analyses were performed on plasma of male mule ducks at different time points during the overfeeding period to obtain a large range of liver characteristics so as to identify plasmatic biomarkers of foie gras. We used two methods, one based on bucket data from the 1H-NMR spectra and another one based on the fingerprints of several metabolites. PLS analyses and Linear models were performed to identify biomarkers. We identified 18 biomarkers of liver weight and 15 biomarkers of technological yield. As these two quality parameters were strongly correlated (−0.82), 13 biomarkers were common. The lactate was the most important biomarker, the other were mainly amino acids. Contrary to the amino acids, the lactate increased with the liver weight and decreased with the technological yield. We also identified 5 biomarkers specific to LW (3 carbohydrates: glucuronic acid, mannose, sorbitol and 2 amino acids: glutamic acid and methionine) that were negatively correlated to liver weight. It was of main interest to identify 2 biomarkers specific to the technological yield. Contrary to the isovaleric acid, the valine was negatively correlated to the technological yield.

Published
2021
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24. Additional file 2 of Integrative mapping analysis of chicken microchromosome 16 organization

Author

Solinhac, Romain, Leroux, Sophie, Galkina, Svetlana, Chazara, Olympe, Feve, Katia, Vignoles, Florence, Morisson, Mireille, Derjusheva, Svetlana, Bed'hom, Bertrand, Vignal, Alain, Fillon, Valérie, and Pitel, Frédérique

Abstract

Additional File 2:454 contigs distribution on the chicken sequence assembly. The 454 contigs ( http://genome.wustl.edu/genomes/view/gallus_gallus/ ) were aligned to the available chicken sequence assembly (galGal 3, http://genome.ucsc.edu/index.html ). The 7 matching contigs are represented along the GGA16 sequence. File format: PowerPoint (PPT 42 KB)

Published
2021
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26. Transcriptome-wide investigation of genomic imprinting in chicken

Author

Frésard, Laure, Leroux, Sophie, Servin, Bertrand, Gourichon, David, Dehais, Patrice, Cristobal, Magali San, Marsaud, Nathalie, Vignoles, Florence, Bedʼhom, Bertrand, Coville, Jean-Luc, Hormozdiari, Farhad, Beaumont, Catherine, Zerjal, Tatiana, Vignal, Alain, Morisson, Mireille, Lagarrigue, Sandrine, and Pitel, Frédérique

Published
2014
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27. Additional file 1 of Ontogeny of hepatic metabolism in mule ducks highlights different gene expression profiles between carbohydrate and lipid metabolic pathways

Author

Massimino, William, Davail, Stéphane, Secula, Aurélie, Andrieux, Charlotte, Marie-Dominique Bernadet, Pioche, Tracy, Ricaud, Karine, Gontier, Karine, Morisson, Mireille, Collin, Anne, Panserat, Stéphane, and Houssier, Marianne

Abstract

Additional file 1: Supplemental Table 1.. Statistical summary of developmental gene expression comparisons over time from E12 to D4. Statistical comparisons over time (E12 to D4) of the gene expressions illustrated in Fig. 1. Depending on shapiro test result, ANOVA with Bonferroni’s multiple comparisons test or Kruskal-Wallis (K-W) with Dunn’s multiple comparisons test were used (n = 14–20). ns: not significant, *: P

Published
2020
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31. Ontogeny of hepatic metabolism in mule ducks highlights different gene expression profiles between carbohydrate and lipid metabolic pathways

Author

Massimino, William, primary, Davail, Stéphane, additional, Seccula, Aurélie, additional, Andrieux, Charlotte, additional, Bernadet, Marie-Dominique, additional, Pioche, Tracy, additional, Ricaud, Karine, additional, Gontier, Karine, additional, Morisson, Mireille, additional, Collin, Anne, additional, Panserat, Stéphane, additional, and Houssier, Marianne, additional

Published
2020
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32. Programmation nutritionnelle du métabolisme hépatique chez le canard mulard

Author

Secula, Aurelie, Bodin, Loys, Chapuis, Herve, Bernadet, Marie-Dominique, BLUY, Lisa, Cobo, Emilie, Barrieu, Josette, bonnefont, Cécile, Lessire, Michel, Mercerand, Frédéric, LE BOURHIS, Maria-Céleste, BRAVO, Céline, Manse, Hélène, Gress, Laure, Genet, Carine, Bonnet, Agnes, Pitel, Frédérique, Brun, Jean- Michel, Morisson, Mireille, Interactions hôtes-agents pathogènes [Toulouse] (IHAP), Institut National de la Recherche Agronomique (INRA)-Ecole Nationale Vétérinaire de Toulouse (ENVT), Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées, Génétique Physiologie et Systèmes d'Elevage (GenPhySE ), École nationale supérieure agronomique de Toulouse [ENSAT]-Institut National de la Recherche Agronomique (INRA)-Ecole Nationale Vétérinaire de Toulouse (ENVT), Palmipèdes à Foie Gras (UEPFG), Institut National de la Recherche Agronomique (INRA), Biologie des Oiseaux et Aviculture (BOA), Institut National de la Recherche Agronomique (INRA)-Université de Tours, Pôle d'Expérimentation Avicole de Tours (UE PEAT), and Institut National de la Recherche Agronomique (INRA)-Université de Tours (UT)

Subjects
[SDV.GEN]Life Sciences [q-bio]/Genetics, [SDV.GEN.GA]Life Sciences [q-bio]/Genetics/Animal genetics, [SDV]Life Sciences [q-bio], [INFO]Computer Science [cs], ComputingMilieux_MISCELLANEOUS
Abstract

National audience

Published
2019

33. CARActérisation Moléculaire de phénomènes Epigénétiques transgénérationneLs chez la caille (CARAMEL)

Author

Leroux, Sophie, Jérémie, Marie, Gourichon, David, Coustham, Vincent, Zerjal, Tatiana, Morisson, Mireille, Bouchez, Olivier, Foissac, Sylvain, Pitel, Frédérique, Génétique Physiologie et Systèmes d'Elevage (GenPhySE ), École nationale supérieure agronomique de Toulouse [ENSAT]-Institut National de la Recherche Agronomique (INRA)-Ecole Nationale Vétérinaire de Toulouse (ENVT), Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées, Pôle d'Expérimentation Avicole de Tours (UE PEAT), Institut National de la Recherche Agronomique (INRA), Biologie des Oiseaux et Aviculture (BOA), Institut National de la Recherche Agronomique (INRA)-Université de Tours (UT), Génétique Animale et Biologie Intégrative (GABI), Institut National de la Recherche Agronomique (INRA)-AgroParisTech, Génome et Transcriptome - Plateforme Génomique (GeT-PlaGe), Institut National de la Recherche Agronomique (INRA)-Plateforme Génome & Transcriptome (GET), Génopole Toulouse Midi-Pyrénées [Auzeville] (GENOTOUL), Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Ecole Nationale Vétérinaire de Toulouse (ENVT), Université Fédérale Toulouse Midi-Pyrénées-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Génopole Toulouse Midi-Pyrénées [Auzeville] (GENOTOUL), Université Fédérale Toulouse Midi-Pyrénées-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), ANR EpiBird (Département de Génétique Animale), Institut National de la Recherche Agronomique (INRA)-Université de Tours, Institut National des Sciences Appliquées - Toulouse (INSA Toulouse), Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Université Toulouse III - Paul Sabatier (UT3), and Université Fédérale Toulouse Midi-Pyrénées-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Institut National des Sciences Appliquées - Toulouse (INSA Toulouse)

Subjects
[SDV.GEN]Life Sciences [q-bio]/Genetics, [SDV.GEN.GA]Life Sciences [q-bio]/Genetics/Animal genetics, [SDV]Life Sciences [q-bio], [INFO]Computer Science [cs], ComputingMilieux_MISCELLANEOUS
Abstract

National audience

Published
2019

34. Effet du moment d'acquisition des spectres proche infrarouge sur la qualité de prédiction du taux de lipides et du taux de fonte du foie gras chez le canard

Author

bonnefont, Cécile, DENEUFBOURG, Chloé, Manse, Hélène, Bernadet, Marie-Dominique, Morisson, Mireille, Génétique Physiologie et Systèmes d'Elevage (GenPhySE ), Institut National de la Recherche Agronomique (INRA)-Ecole Nationale Vétérinaire de Toulouse (ENVT), Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-École nationale supérieure agronomique de Toulouse [ENSAT], Palmipèdes à Foie Gras (UEPFG), Institut National de la Recherche Agronomique (INRA), École nationale supérieure agronomique de Toulouse [ENSAT]-Institut National de la Recherche Agronomique (INRA)-Ecole Nationale Vétérinaire de Toulouse (ENVT), and Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées

Subjects
[SDV.OT]Life Sciences [q-bio]/Other [q-bio.OT], NIRS, teneur lipide, foie gras, prédiction, taux de fonte, Autre (Sciences du Vivant)
Abstract

Pour caractériser la composition biochimique des tissus animaux,la spectrométrie proche infrarouge (SPIR) est de plus en plus utilisée. Des études précédentes sur le foie gras ont montré la capacité de prédire le taux de lipides et le taux de fonte. L’objectif de ce travail est d’étudier l’effet du moment d’acquisition des spectres sur la qualité de prédiction de ces deux grandeurs. Des spectres infrarouges ont été acquis deux fois sur les mêmes foies gras, en post éviscération (PE) et en post refroidissement (PEPR). Les données spectrales ont été collectées en réflectance (R) dans les régions du visible et du PIR (350-2500 nm, pas de 1 nm) avec un spectromètre portable LabSpec® 5000 (ASD Inc., Boulder (CO), USA) équipé d'un module de contact. Le taux de fonte à la cuisson (n=182) et le taux de lipides (n=125) ont été mesurés. Chacun des groupes de spectres PE et PEPR ont été séparés en deux jeux de données, un jeu de calibration (2/3 des échantillons) et un jeu de validation afin d’établir des équations de prédiction de la composition des foies. Les deux jeux de calibration ainsi que les deux jeux de validation ont aussi été regroupés afin d’établir une équation de prédiction globale. Le traitement des spectres et le développement des équations de prédiction ont été réalisés avec le logiciel WinISI (version 4.6.8, FOSSAnalytical A/S, Hilleroed, Danemark) sur une fenêtre de 650 à 2350 nm. Les équations de prédiction ont été établies par régression partielle des moindres carrés (mPLS du logiciel WinISI) après transformation des données par une Standard Normal Variate andDetrend (SNVD) avec une dérivée première et un lissage de 10 (1/10/10/1).Les équations développées avec les spectres acquis en post éviscération permettent de prédire le taux de fonte et le taux de lipides des foies dont les spectres ont été acquis au même moment post-mortem, mais ne permettent pas de prédire ces grandeurs pour des spectres acquis en post refroidissement. Des résultats similaires ont été obtenus sur les spectres en post refroidissement. En outre, les équations développées sur l’ensemble des spectres disponibles ont une qualité de prédiction équivalente à celles citées précédemment. Ainsi, il est possible de rassembler des spectres acquis à différents moments post mortem et de faire une seule équation afin de prédire soit le taux de lipidesdes foies soit leur taux de fonte

Published
2019

35. Impact d'une manipulation thermique pendant l'embryogénèse sur la production de foie gras des canards mulards

Author

Massimino, William, Davail, Stéphane, Bernadet, Marie-Dominique, Pioche, Tracy, Ricaud, Karine, GONTIER, Karine, bonnefont, Cécile, Manse, Hélène, Morisson, Mireille, Collin, Anne, Panserat, Stephane, Houssier, Marianne, Nutrition, Métabolisme, Aquaculture (NuMéA), Institut National de la Recherche Agronomique (INRA)-Université de Pau et des Pays de l'Adour (UPPA), Palmipèdes à Foie Gras (UEPFG), Institut National de la Recherche Agronomique (INRA), Génétique Physiologie et Systèmes d'Elevage (GenPhySE ), École nationale supérieure agronomique de Toulouse [ENSAT]-Institut National de la Recherche Agronomique (INRA)-Ecole Nationale Vétérinaire de Toulouse (ENVT), Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées, Unité de Recherches Avicoles (URA), CIFOG - Conseil Départemental des Landes, Institut National de la Recherche Agronomique (INRA)-Ecole Nationale Vétérinaire de Toulouse (ENVT), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-École nationale supérieure agronomique de Toulouse [ENSAT], and Recherches Avicoles (SRA)

Subjects
production de foie gras, éclosion, gavage, température d'incubation, [SDV.BA]Life Sciences [q-bio]/Animal biology, hatching, force feeding, embryogénèse, foie gras, canard mulard
Abstract

Résumé; Previous studies have shown that very early life events could have programming effects on adult physiology. Exposing poultry embryos to higher incubation temperatures improve their survival capacity to thermal challenge in adulthood. Recently, embryonic thermal manipulation (TM) has been shown to impact muscle development and hepatic metabolism in Pekin ducks. In this study, we aimed to test whether rising incubation temperature has an impact on development, growth and zootechnical performances in mule ducks, mainly used for fatty liver production. Different thermal incubation conditions were applied during embryogenesis on mule duck eggs with three TM groups and one control, for which the temperature was maintained stable throughout. A faster embryonic and growth development was observed for all TM groups. Significant changes in body temperature and body weight were measured at hatching time and throughout the breeding period. Finally, overfeeding induced significant increase of live body weight, leg muscle, fat, and liver weights in all groups, while embryonic TM significantly increased abdominal fat and liver weights compared to control overfed group.These results suggest that embryonic TM can improve fatty liver production in male mule ducks, nevertheless potential deleterious effects on eclosability need to be explored further.; Différentes études ont montré que des événements survenus très tôt dans la vie d’un animal pouvaient avoir des effets de « programmation » sur la physiologie de l’adulte. L'exposition d'embryons de volaille à des températures d'incubation élevées améliore leur capacité de survie lors de pics de chaleur à l'âge adulte.Récemment, il a été démontré que la manipulation thermique embryonnaire (MT) avait un impact sur le développement musculaire et le métabolisme hépatique chez les canards Pékin. Dans cette étude, notre objectif était de mesurer l’impact d’une élévation de la température d'incubation sur le développement, la croissance et les performances des canards mulards, principalement utilisés pour la production de foie gras.Nous avons testé trois modalités expérimentales d’augmentation de la température dans l’incubateur sur des embryons de canards mulards, parallèlement un groupe témoin était maintenu à température constante tout au long de l’embryogenèse. Une éclosion plus précoce a été observée pour tous les groupes soumis à une MT (1 jour d’avance en moyenne). Des changements significatifs de la température et du poids corporels ont été mesurés à l'éclosion et tout au long de l’élevage. Enfin, le gavage a entraîné une augmentation significative du poids vif , des muscles de la cuisse, du tissu adipeux et du foie dans tous les groupes traités, tandis qu’une MT embryonnaire augmentait de manière significative le poids de graisse abdominale (jusqu’à +13,3% ; P=0,0001)et du foie (jusqu’à +16,9% ; P

Published
2019

37. Diversification : de nouveaux traits, de nouvelles espèces pour de nouveaux services et une stabilité des rendements en conditions de faibles intrants

Author

Cailliatte, Rémy, Enjalbert, Jerome, Morisson, Mireille, Moreau, Delphine, Litrico-Chiarelli, Isabelle, EL Mjiyad, Noureddine, INRA Domaine Saint-Paul - Site Agroparc 228 route de l'Aérodrome AVIGNON CEDEX 9 (FRANCE, Génétique Quantitative et Evolution - Le Moulon (Génétique Végétale) (GQE-Le Moulon), Centre National de la Recherche Scientifique (CNRS)-AgroParisTech-Université Paris-Sud - Paris 11 (UP11)-Institut National de la Recherche Agronomique (INRA), INRA, UMR444 Génétique Cellulaire, F-31326 Castanet-Tolosan, France, Agroécologie [Dijon], Université de Bourgogne (UB)-Institut National de la Recherche Agronomique (INRA)-Université Bourgogne Franche-Comté [COMUE] (UBFC)-AgroSup Dijon - Institut National Supérieur des Sciences Agronomiques, de l'Alimentation et de l'Environnement, and Directrice de Recherche INRAE poitiers

Subjects
[SDE] Environmental Sciences, [SDE]Environmental Sciences, ComputingMilieux_MISCELLANEOUS
Abstract

National audience

Published
2019

39. Avian Expression Patterns and Genomic Mapping Implicate Leptin in Digestion and TNF in Immunity, Suggesting That Their Interacting Adipokine Role Has Been Acquired Only in Mammals

Author

Seroussi, Eyal, Knytl, Martin, Pitel, Frederique, Elleder, Daniel, Krylov, Vladimir, Leroux, Sophie, Morisson, Mireille, Yosefi, Sara, Miyara, Shoval, Ganesan, Saibaba, Ruzal, Mark, Andersson, Leif, Friedman-Einat, Miriam, Seroussi, Eyal, Knytl, Martin, Pitel, Frederique, Elleder, Daniel, Krylov, Vladimir, Leroux, Sophie, Morisson, Mireille, Yosefi, Sara, Miyara, Shoval, Ganesan, Saibaba, Ruzal, Mark, Andersson, Leif, and Friedman-Einat, Miriam

Abstract

In mammals, leptin and tumor-necrosis factor (TNF) are prominent interacting adipokines mediating appetite control and insulin sensitivity. While TNF pleiotropically functions in immune defense and cell survival, leptin is largely confined to signaling energy stores in adipocytes. Knowledge about the function of avian leptin and TNF is limited and they are absent or lowly expressed in adipose, respectively. Employing radiation-hybrid mapping and FISH-TSA, we mapped TNF and its syntenic genes to chicken chromosome 16 within the major histocompatibility complex (MHC) region. This mapping position suggests that avian TNF has a role in regulating immune response. To test its possible interaction with leptin within the immune system and beyond, we compared the transcription patterns of TNF, leptin and their cognate receptors obtained by meta-analysis of GenBank RNA-seq data. While expression of leptin and its receptor (LEPR) were detected in the brain and digestive tract, TNF and its receptor mRNAs were primarily found in viral-infected and LPS-treated leukocytes. We confirmed leptin expression in the duodenum by immunohistochemistry staining. Altogether, we suggest that whereas leptin and TNF interact as adipokines in mammals, in birds, they have distinct roles. Thus, the interaction between leptin and TNF may be unique to mammals.

Published
2019
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42. A duck RH panel and its potential for assisting NGS genome assembly

Author

Rao Man, Morisson Mireille, Faraut Thomas, Bardes Suzanne, Fève Katia, Labarthe Emmanuelle, Fillon Valérie, Huang Yinhua, Li Ning, and Vignal Alain

Subjects
RH mapping, NGS, Sequencing, Duck, Scaffold, Assembly, Biotechnology, TP248.13-248.65, Genetics, QH426-470
Abstract

Abstract Background Owing to the low cost of the high throughput Next Generation Sequencing (NGS) technology, more and more species have been and will be sequenced. However, de novo assemblies of large eukaryotic genomes thus produced are composed of a large number of contigs and scaffolds of medium to small size, having no chromosomal assignment. Radiation hybrid (RH) mapping is a powerful tool for building whole genome maps and has been used for several animal species, to help assign sequence scaffolds to chromosomes and determining their order. Results We report here a duck whole genome RH panel obtained by fusing female duck embryonic fibroblasts irradiated at a dose of 6,000 rads, with HPRT-deficient Wg3hCl2 hamster cells. The ninety best hybrids, having an average retention of 23.6% of the duck genome, were selected for the final panel. To allow the genotyping of large numbers of markers, as required for whole genome mapping, without having to cultivate the hybrid clones on a large scale, three different methods involving Whole Genome Amplification (WGA) and/or scaling down PCR volumes by using the Fluidigm BioMarkTM Integrated Fluidic Circuits (IFC) Dynamic ArrayTM for genotyping were tested. RH maps of APL12 and APL22 were built, allowing the detection of intrachromosomal rearrangements when compared to chicken. Finally, the panel proved useful for checking the assembly of sequence scaffolds and for mapping EST located on one of the smallest microchromosomes. Conclusion The Fluidigm BioMarkTM Integrated Fluidic Circuits (IFC) Dynamic ArrayTM genotyping by quantitative PCR provides a rapid and cost-effective method for building RH linkage groups. Although the vast majority of genotyped markers exhibited a picture coherent with their associated scaffolds, a few of them were discordant, pinpointing potential assembly errors. Comparative mapping with chicken chromosomes GGA21 and GGA11 allowed the detection of the first chromosome rearrangements on microchromosomes between duck and chicken. As in chicken, the smallest duck microchromosomes appear missing in the assembly and more EST data will be needed for mapping them. Altogether, this underlines the added value of RH mapping to improve genome assemblies.

Published
2012
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43. Transgenerational epigenetic inheritance in birds

Author

Guerrero-Bosagna, Carlos, Morisson, Mireille, Liaubet, Laurence, Rodenburg, T. Bas, de Haas, Elske N., Kost'al, L'ubor, Pitel, Frederique, LS GZ Landbouwhuisdieren, dASS BW-2, Animal Welfare, and dFAH I&I

Subjects
birds, transgenerational epigenetics, non-mendelian inheritance, environment, behaviour
Abstract

While it has been shown that epigenetics accounts for a portion of the variability of complex traits linked to interactions with the environment, the real contribution of epigenetics to phenotypic variation remains to be assessed. In recent years, a growing number of studies have revealed that epigenetic modifications can be transmitted across generations in several animal species. Numerous studies have demonstrated inter- or multi-generational effects of changing environment in birds, but very few studies have been published showing epigenetic transgenerational inheritance in these species. In this review, we mention work conducted in parent-to-offspring transmission analyses in bird species, with a focus on the impact of early stressors on behaviour. We then present recent advances in transgenerational epigenetics in birds, which involve germline linked non-Mendelian inheritance, underline the advantages and drawbacks of working on birds in this field and comment on future directions of transgenerational studies in bird species.

Published
2018

44. Positive Impact of Thermal Manipulation During Embryogenesis on Foie Gras Production in Mule Ducks

Author

Massimino, William, primary, Davail, Stéphane, additional, Bernadet, Marie-Dominique, additional, Pioche, Tracy, additional, Tavernier, Annabelle, additional, Ricaud, Karine, additional, Gontier, Karine, additional, Bonnefont, Cécile, additional, Manse, Hélène, additional, Morisson, Mireille, additional, Fauconneau, Benoit, additional, Collin, Anne, additional, Panserat, Stéphane, additional, and Houssier, Marianne, additional

Published
2019
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46. Avian Expression Patterns and Genomic Mapping Implicate Leptin in Digestion and TNF Signaling, Suggesting that Their Interacting Adipokine Role is Unique to Mammals

Author

Seroussi, Eyal, primary, Knytl, Martin, additional, Pitel, Frédérique, additional, Elleder, Daniel, additional, Krylov, Vladimir, additional, Leroux, Sophie, additional, Morisson, Mireille, additional, Yosefi, Sara, additional, Miyara, Shoval, additional, Ganesan, Saibaba, additional, Ruzal, Mark, additional, Andersson, Leif, additional, and Friedman-Einat, Miriam, additional

Published
2019
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50. Integrative mapping analysis of chicken microchromosome 16 organization

Author

Bed'hom Bertrand, Derjusheva Svetlana, Morisson Mireille, Vignoles Florence, Feve Katia, Chazara Olympe, Galkina Svetlana, Leroux Sophie, Solinhac Romain, Vignal Alain, Fillon Valérie, and Pitel Frédérique

Subjects
Biotechnology, TP248.13-248.65, Genetics, QH426-470
Abstract

Abstract Background The chicken karyotype is composed of 39 chromosome pairs, of which 9 still remain totally absent from the current genome sequence assembly, despite international efforts towards complete coverage. Some others are only very partially sequenced, amongst which microchromosome 16 (GGA16), particularly under-represented, with only 433 kb assembled for a full estimated size of 9 to 11 Mb. Besides the obvious need of full genome coverage with genetic markers for QTL (Quantitative Trait Loci) mapping and major genes identification studies, there is a major interest in the detailed study of this chromosome because it carries the two genetically independent MHC complexes B and Y. In addition, GGA16 carries the ribosomal RNA (rRNA) genes cluster, also known as the NOR (nucleolus organizer region). The purpose of the present study is to construct and present high resolution integrated maps of GGA16 to refine its organization and improve its coverage with genetic markers. Results We developed 79 STS (Sequence Tagged Site) markers to build a physical RH (radiation hybrid) map and 34 genetic markers to extend the genetic map of GGA16. We screened a BAC (Bacterial Artificial Chromosome) library with markers for the MHC-B, MHC-Y and rRNA complexes. Selected clones were used to perform high resolution FISH (Fluorescent In Situ Hybridization) mapping on giant meiotic lampbrush chromosomes, allowing meiotic mapping in addition to the confirmation of the order of the three clusters along the chromosome. A region with high recombination rates and containing PO41 repeated elements separates the two MHC complexes. Conclusions The three complementary mapping strategies used refine greatly our knowledge of chicken microchromosome 16 organisation. The characterisation of the recombination hotspots separating the two MHC complexes demonstrates the presence of PO41 repetitive sequences both in tandem and inverted orientation. However, this region still needs to be studied in more detail.

Published
2010
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