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23 results on '"Morizot, Frederique"'

1. Extracellular Vesicles in Human Skin: Cross-Talk from Senescent Fibroblasts to Keratinocytes by miRNAs

Author

Terlecki-Zaniewicz, Lucia, Pils, Vera, Bobbili, Madhusudhan Reddy, Lämmermann, Ingo, Perrotta, Ida, Grillenberger, Tonja, Schwestka, Jennifer, Weiß, Katrin, Pum, Dietmar, Arcalis, Elsa, Schwingenschuh, Simon, Birngruber, Thomas, Brandstetter, Marlene, Heuser, Thomas, Schosserer, Markus, Morizot, Frederique, Mildner, Michael, Stöger, Eva, Tschachler, Erwin, Weinmüllner, Regina, Gruber, Florian, and Grillari, Johannes

Published
2019
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2. Towards Continuous Health Diagnosis from Faces with Deep Learning

Author

Martin, Victor, Séguier, Renaud, Porcheron, Aurélie, Morizot, Frédérique, Hutchison, David, Series Editor, Kanade, Takeo, Series Editor, Kittler, Josef, Series Editor, Kleinberg, Jon M., Series Editor, Mattern, Friedemann, Series Editor, Mitchell, John C., Series Editor, Naor, Moni, Series Editor, Pandu Rangan, C., Series Editor, Steffen, Bernhard, Series Editor, Terzopoulos, Demetri, Series Editor, Tygar, Doug, Series Editor, Weikum, Gerhard, Series Editor, Rekik, Islem, editor, Unal, Gozde, editor, Adeli, Ehsan, editor, and Park, Sang Hyun, editor

Published
2018
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6. Identification of New Biological Pathways Involved in Skin Aging From the Analysis of French Women Genome-Wide Data

Author

Rahmouni, Myriam, primary, Laville, Vincent, additional, Spadoni, Jean-Louis, additional, Jdid, Randa, additional, Eckhart, Leopold, additional, Gruber, Florian, additional, Labib, Taoufik, additional, Coulonges, Cedric, additional, Carpentier, Wassila, additional, Latreille, Julie, additional, Morizot, Frederique, additional, Tschachler, Erwin, additional, Ezzedine, Khaled, additional, Le Clerc, Sigrid, additional, and Zagury, Jean-François, additional

Published
2022
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7. Identification of New Biological Pathways Involved in Skin Aging From the Analysis of French Women Genome-Wide Data

Author

Rahmouni, Myriam, Laville, Vincent, Spadoni, Jean-Louis, Jdid, Randa, Eckhart, Leopold, Gruber, Florian, Labib, Taoufik, Coulonges, Cedric, Carpentier, Wassila, Latreille, Julie, Morizot, Frederique, Tschachler, Erwin, Ezzedine, Khaled, Le Clerc, Sigrid, Zagury, Jean-François, Laboratoire Génomique, bioinformatique et chimie moléculaire (GBCM), Conservatoire National des Arts et Métiers [CNAM] (CNAM), HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM), Chanel, Medizinische Universität Wien = Medical University of Vienna, Plateforme Post-génomique de la Pitié-Salpêtrière (PASS-P3S), Unité Mixte de Service Production et Analyse de données en Sciences de la vie et en Santé (PASS), Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU), Hôpital Henri Mondor, Epidemiology in Dermatology and Evaluation in Therapeutics (EpiDermE), and Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12)

Subjects
skin, integumentary system, pathway, aging, Genetics, Molecular Medicine, SNP, GWAS, [SDV.BBM]Life Sciences [q-bio]/Biochemistry, Molecular Biology, Genetics (clinical)
Abstract

Skin aging is an ineluctable process leading to the progressive loss of tissue integrity and is characterized by various outcomes such as wrinkling and sagging. Researchers have identified impacting environmental factors (sun exposure, smoking, etc.) and several molecular mechanisms leading to skin aging. We have previously performed genome-wide association studies (GWAS) in 502 very-well characterized French women, looking for associations with four major outcomes of skin aging, namely, photoaging, solar lentigines, wrinkling, and sagging, and this has led to new insights into the molecular mechanisms of skin aging. Since individual SNP associations in GWAS explain only a small fraction of the genetic impact in complex polygenic phenotypes, we have made the integration of these genotypes into the reference Kegg biological pathways and looked for associations by the gene set enrichment analysis (GSEA) approach. 106 pathways were tested for association with the four outcomes of skin aging. This biological pathway analysis revealed new relevant pathways and genes, some likely specific of skin aging such as the WNT7B and PRKCA genes in the “melanogenesis” pathway and some likely involved in global aging such as the DDB1 gene in the “nucleotide excision repair” pathway, not picked up in the previously published GWAS. Overall, our results suggest that the four outcomes of skin aging possess specific molecular mechanisms such as the “proteasome” and “mTOR signaling pathway” but may also share common molecular mechanisms such as “nucleotide excision repair.”

Published
2021
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11. Sensitive Skin

Author

Morizot, Frederique

Subjects
Pharmaceutical industry -- Research, Business, Pharmaceuticals and cosmetics industries
Abstract

The study examines symptoms arising from sensitive skin. The authors provide a literature review of the skin condition in the cosmetics industry and related publications.

Published
2000

13. A genome-wide association study in Caucasian women suggests the involvement ofHLAgenes in the severity of facial solar lentigines

Author

Laville, Vincent, primary, Clerc, Sigrid Le, additional, Ezzedine, Khaled, additional, Jdid, Randa, additional, Taing, Lieng, additional, Labib, Taoufik, additional, Coulonges, Cedric, additional, Ulveling, Damien, additional, Carpentier, Wassila, additional, Galan, Pilar, additional, Hercberg, Serge, additional, Morizot, Frederique, additional, Latreille, Julie, additional, Malvy, Denis, additional, Tschachler, Erwin, additional, and Zagury, Jean‐François, additional

Published
2016
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17. A genome-wide association study in Caucasian women suggests the involvement of HLA genes in the severity of facial solar lentigines.

Author

Laville, Vincent, Clerc, Sigrid Le, Ezzedine, Khaled, Jdid, Randa, Taing, Lieng, Labib, Taoufik, Coulonges, Cedric, Ulveling, Damien, Carpentier, Wassila, Galan, Pilar, Hercberg, Serge, Morizot, Frederique, Latreille, Julie, Malvy, Denis, Tschachler, Erwin, and Zagury, Jean ‐ François

Subjects
LENTIGO, METASTASIS, SKIN aging, GENETICS, GENOMES
Abstract

Solar lentigines are a common feature of sun-induced skin ageing. Little is known, however, about the genetic factors contributing to their development. In this genome-wide association study, we aimed to identify genetic loci associated with solar lentigines on the face in 502 middle-aged French women. Nine SNPs, gathered in two independent blocks on chromosome 6, exhibited a false discovery rate below 25% when looking for associations with the facial lentigine score. The first block, in the 6p22 region, corresponded to intergenic SNPs and also exhibited a significant association with forehead lentigines (P = 1.37 × 10−8). The second block, within the 6p21 HLA region, was associated with decreased HLA-C expression according to several eQTL databases. Interestingly, these SNPs were also in high linkage disequilibrium with the HLA-C*0701 allele ( r2 = 0.95). We replicated an association recently found by GWAS in the IRF4 gene. Finally, a complementary study on 44 selected candidate SNPs revealed novel associations in the MITF gene. Overall, our results point to several mechanisms involved in the severity of facial lentigines, including HLA/immunity and the melanogenesis pathway. [ABSTRACT FROM AUTHOR]

Published
2016
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21. Ethnic Differences in Skin Aging.

Author

Gilchrest, Barbara A., Krutmann, Jean, Tschachler, Erwin, and Morizot, Frederique

Subjects
SKIN aging, WRINKLES (Skin), FOOD habits, LIFESTYLES, HUMAN skin color
Abstract

Ethnic differences in skin properties has attracted great interest in the past, but apart from the visible differences in pigmentation, their assessment has frequently yielded indefinite or conflicting results. Whereas it is self-evident that skin aging affects all human beings regardless of their ethnic background, it is commonly assumed that differences in the rate of appearance of the signs of aging exist between different ethnic groups. As far as premature aging due to sun exposure is concerned, evidence exists that natural photoprotection by melanin and melanosomal dispersion influences both the severity and manifestations of photoaging. Unfortunately, there are only a few studies in which aging and photoaging were compared directly in the context of different racial backgrounds. This is probably, at least in part, due to the fact that for such a study a multitude of confounding factors such as differences in environment, food and life-style habits of the different ethnic groups cannot be easily controlled for. Aware of these constraints, we sought to determine whether defined signs of skin aging appear at comparable severity and rates in Japanese and French women and were able to show that the two study populations differed in the rate of appearance of different types of wrinkles and age-associated pigment changes. [ABSTRACT FROM AUTHOR]

Published
2006
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22. Transepidermal water loss, temperature and sebum levels on women's facial skin follow characteristic patterns.

Author

Lopez, Sabine, Le Fur, Isabelle, Morizot, Frederique, Heuvin, Guylaine, Guinot, Christiane, and Tschachler, Erwin

Subjects
FACE, SKIN, CHEMICALS
Abstract

Provides information on a study which compared the biophysical properties of different facial zones in women. Background on the significance of anatomical variation to the response of the skin to chemical agents; Materials and methodology; Results and discussion.

Published
2000
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23. Comparison of cheek and forehead regions by bioengineering methods in women with different self-reported 'cosmetic skin types.'

Author

Le Fur, Isabelle, Lopez, Sabine, Morizot, Frederique, Guinot, Christiane, and Tschachler, Erwin

Subjects
SKIN, PHYSICAL biochemistry, COSMETICS, CHEEK, WOMEN'S health
Abstract

Deals with a study which compared biophysical parameters on malar and frontal facial areas of healthy women classified according to self-reported cosmetic skin types. Material and methods; Results; Discussion.

Published
1999
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