1. Essential versus accessory aspects of cell death: recommendations of the NCCD 2015
- Author
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Lorenzo Galluzzi, Thomas Rudel, Hans-Uwe Simon, Vishva M. Dixit, Erwin F. Wagner, Marie-Lise Gougeon, Andreas Linkermann, J M Bravo-San Pedro, Rosario Rizzuto, Cecília M. P. Rodrigues, Gian Maria Fimia, Hidenori Ichijo, Mathieu J.M. Bertrand, Kodi S. Ravichandran, Francis Ka-Ming Chan, Stephen W.G. Tait, Jochen H. M. Prehn, Richard A. Lockshin, Valina L. Dawson, Andreas Villunger, Sharad Kumar, Emily H. Cheng, Carlos López-Otín, Theocharis Panaretakis, Lucia Altucci, Gabriel A. Rabinovich, Michelangelo Campanella, Peter Vandenabeele, Marcus E. Peter, Francesco Cecconi, Noboru Mizushima, Ilio Vitale, Frank Madeo, Mikhail V. Blagosklonny, Zahra Zakeri, Stuart A. Aaronson, Gabriel Núñez, Eric H. Baehrecke, Nektarios Tavernarakis, Gyorgy Szabadkai, Eleonora Candi, Brent R. Stockwell, Dale E. Bredesen, Seamus J. Martin, Thomas Kaufmann, Sonia Melino, Dieter Adam, John M. Abrams, Katiuscia Bianchi, Yufang Shi, Emad S. Alnemri, Klas Blomgren, Pascal Meier, Catherine Brenner, Michael O. Hengartner, Philipp J. Jost, J M Hardwick, Eileen White, T Vanden Berghe, N. Di Daniele, Nicolas G. Bazan, H. L. Tang, Mauro Piacentini, V De Laurenzi, Beth Levine, Margherita Annicchiarico-Petruzzelli, Josef M. Penninger, Walter Malorni, Ted M. Dawson, Carmen Garrido, David W. Andrews, Douglas R. Green, György Hajnóczky, Jerry E. Chipuk, Wafik S. El-Deiry, Christoph Borner, Stuart A. Lipton, John A. Cidlowski, Klaus-Michael Debatin, Junying Yuan, Jan Paul Medema, Bertrand Joseph, Aaron Ciechanover, Ute M. Moll, Hinrich Gronemeyer, Paolo Pinton, Gerry Melino, Daniel J. Klionsky, Simone Fulda, John J. Lemasters, Cristina Muñoz-Pinedo, Hamsa Puthalakath, Navdeep S. Chandel, R De Maria, Jean-Christophe Marine, Richard A. Flavell, Brian David Dynlacht, W. G. Wood, Henning Walczak, David C. Rubinsztein, Guido Kroemer, Oliver Kepp, Richard A. Knight, Andrew Oberst, Enrico Lugli, J-C Martinou, Boris Zhivotovsky, Yoshihide Tsujimoto, Galluzi, L, Bravo-San, Pedro JM, Vitale, I, Aaaronson, SA, Kumar, S, Kroemer, Guido, Galluzzi, L, Bravo San Pedro, J. M, Aaronson, S. A, Abrams, J. M, Adam, D, Alnemri, E. S, Altucci, L, Andrews, D, Annicchiarico Petruzzelli, M, Baehrecke, E. H, Bazan, N. G, Bertrand, M. J, Bianchi, K, Blagosklonny, M. V, Blomgren, K, Borner, C, Bredesen, D. E, Brenner, C, Campanella, M, Candi, E, Cecconi, F, Chan, F. K, Chandel, N. S, Cheng, E. H, Chipuk, J. E, Cidlowski, J. A, Ciechanover, A, Dawson, T. M, Dawson, V. L, De Laurenzi, V, De Maria, R, Debatin, K. M, Di Daniele, N, Dixit, V. M, Dynlacht, B. D, El Deiry, W. S, Fimia, Gian Maria, Flavell, R. A, Fulda, S, Garrido, C, Gougeon, M. L, Green, D. R, Gronemeyer, H, Hajnoczky, G, Hardwick, J. M, Hengartner, M. O, Ichijo, H, Joseph, B, Jost, P. J, Kaufmann, T, Kepp, O, Klionsky, D. J, Knight, R. A, Lemasters, J. J, Levine, B, Linkermann, A, Lipton, S. A, Lockshin, R. A, López Otín, C, Lugli, E, Madeo, F, Malorni, W, Marine, J. C, Martin, S. J, Martinou, J. C, Medema, J. P, Meier, P, Melino, S, Mizushima, N, Moll, U, Muñoz Pinedo, C, Nuñez, G, Oberst, A, Panaretakis, T, Penninger, J. M, Peter, M. E, Piacentini, M, Pinton, P, Prehn, J. H, Puthalakath, H, Rabinovich, G. A, Ravichandran, K. S, Rizzuto, R, Rodrigues, C. M, Rubinsztein, D. C, Rudel, T, Shi, Y, Simon, H. U, Stockwell, B. R, Szabadkai, G, Tait, S. W, Tang, H. L, Tavernarakis, N, Tsujimoto, Y, Vanden Berghe, T, Vandenabeele, P, Villunger, A, Wagner, E. F, Walczak, H, White, E, Wood, W. G, Yuan, J, Zakeri, Z, Zhivotovsky, B, Melino, G, Kroemer, G., Bravo San Pedro, Jm, Aaronson, Sa, Abrams, Jm, Alnemri, E, Altucci, Lucia, Baehrecke, Eh, Bazan, Ng, Bertrand, Mj, Blagosklonny, Mv, Bredesen, De, Chan, Fk, Chandel, N, Cheng, Eh, Chipuk, Je, Cidlowski, Ja, Dawson, Tm, Dawson, Vl, Debatin, Km, Dixit, Vm, Dynlacht, Bd, El Deiry, W, Fimia, Gm, Flavell, Ra, Gougeon, Ml, Green, Dr, Hardwick, Jm, Hengartner, Mo, Jost, Pj, Klionsky, Dj, Knight, Ra, Lemasters, Jj, Lipton, Sa, Lockshin, Ra, Marine, Jc, Martin, Sj, Martinou, Jc, Medema, Jp, Penninger, Jm, Peter, Me, Prehn, Jh, Rabinovich, Ga, Ravichandran, K, Rodrigues, Cm, Rubinsztein, Dc, Simon, Hu, Stockwell, Br, Tait, Sw, Tang, Hl, Wagner, Ef, and Wood, Wg
- Subjects
Biochemical Manifestations of Cell Death ,ISCHEMIA-REPERFUSION INJURY ,Apoptosis ,Review ,Transduction (genetics) ,0302 clinical medicine ,CASPASE INHIBITION SWITCHES ,Animals ,Humans ,Terminology as Topic ,Signal Transduction ,610 Medicine & health ,Caspase ,TUMOR-NECROSIS-FACTOR ,0303 health sciences ,Settore BIO/17 ,biology ,Settore BIO/11 ,Neurodegeneration ,Settore BIO/13 ,APOPTOSIS ,3. Good health ,Medicina Básica ,cell death ,030220 oncology & carcinogenesis ,Morphologic Aspects of Cell Death ,Signal transduction ,DOMAIN-LIKE PROTEIN ,Intracellular ,Human ,Necroptosi ,CYTOCHROME-C RELEASE ,OUTER-MEMBRANE PERMEABILIZATION ,Programmed cell death ,CIENCIAS MÉDICAS Y DE LA SALUD ,Settore BIO/06 ,Inmunología ,CELL DEATH ,NO ,Q-VD-OPH ,03 medical and health sciences ,Settore MED/04 - PATOLOGIA GENERALE ,ddc:570 ,APOPTOSIS-INDUCING FACTOR ,MIXED LINEAGE KINASE ,medicine ,Molecular Biology ,Cell Biology ,Settore BIO/10 ,030304 developmental biology ,Animal ,Cell growth ,Apoptosi ,Biology and Life Sciences ,medicine.disease ,MITOCHONDRIAL PERMEABILITY TRANSITION ,Immunology ,biology.protein ,Neuroscience - Abstract
Cells exposed to extreme physicochemical or mechanical stimuli die in an uncontrollable manner, as a result of their immediate structural breakdown. Such an unavoidable variant of cellular demise is generally referred to as ?accidental cell death' (ACD). In most settings, however, cell death is initiated by a genetically encoded apparatus, correlating with the fact that its course can be altered by pharmacologic or genetic interventions. "Regulated cell death" (RCD) can occur as part of physiologic programs or can be activated once adaptive responses to perturbations of the extracellular or intracellular microenvironment fail. The biochemical phenomena that accompany RCD may be harnessed to classify it into a few subtypes, which often (but not always) exhibit stereotyped morphologic features. Nonetheless, efficiently inhibiting the processes that are commonly thought to cause RCD, such as the activation of executioner caspases in the course of apoptosis, does not exert true cytoprotective effects in the mammalian system, but simply alters the kinetics of cellular demise as it shifts its morphologic and biochemical correlates. Conversely, bona fide cytoprotection can be achieved by inhibiting the transduction of lethal signals in the early phases of the process, when adaptive responses are still operational. Thus, the mechanisms that truly execute RCD may be less understood, less inhibitable and perhaps more homogeneous than previously thought. Here, the Nomenclature Committee on Cell Death formulates a set of recommendations to help scientists and researchers to discriminate between essential and accessory aspects of cell death Fil: Rabinovich, Gabriel Adrian. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental (i); Argentina Fil: Nomenclature Committee on Cell Death. Equipe 11 Apoptose, Cancer et Immunité. Centre de Recherche des Cordeliers; Francia
- Published
- 2015