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4. SARS-CoV-2 Infection in San Patrignano, the Largest European Drug Rehabilitation Community

Author

Sala, I, Jarach, C, Bagnardi, V, Cattaruzza, M, Morri, M, Ottogalli, P, Zaga, V, Gallus, S, Boschini, A, Sala I., Jarach C. M., Bagnardi V., Cattaruzza M. S., Morri M., Ottogalli P., Zaga V., Gallus S., Boschini A., Sala, I, Jarach, C, Bagnardi, V, Cattaruzza, M, Morri, M, Ottogalli, P, Zaga, V, Gallus, S, Boschini, A, Sala I., Jarach C. M., Bagnardi V., Cattaruzza M. S., Morri M., Ottogalli P., Zaga V., Gallus S., and Boschini A.

Abstract

Background: Studies on SARS-CoV-2 conducted in confined settings for prolonged times allow researchers to assess how the coronavirus spreads. San Patrignano (SP), Italy, is the largest European drug rehabilitation facility. Methods: Between 15 October and 31 December 2020, all SP residents were tested for SARS-CoV-2. We analyzed the relationships between individual characteristics and being SARS-CoV-2-positive. Three selected predictive models were used to calculate the number of expected hospitalizations. For each model, we summed the estimated individual risks to obtain the expected number of hospitalizations in our sample, and we tested whether the observed and expected numbers differed. Results: Of 807 residents, 529 (65.6%) were SARS-CoV-2-positive. Of these 323 (61.1%) were symptomatic. A strong relationship was found between being positive and living connections (p-value < 0.001). No statistically significant relationship was found with age, sex, smoking history, or comorbidities. Although 9 to 17 hospitalizations were expected, no hospitalizations were observed (p-value < 0.001). No one died of COVID-19. Conclusions: The peculiar characteristics of SP residents or the SP environment might at least partially explain the null hospitalization rates. Despite the extreme uniqueness of our population and despite the protected environment and all precautions that were taken, the fact that the virus was able to circulate and infect a large portion of the population highlights the fundamental role of social interactions in the spread of the disease.

Published
2023

7. Evaluation of chitosan salt properties in the production of AgNPs materials with antibacterial activity

Author

Aranaz, I, Navarro-García, F, Morri, M, Acosta, N, Casettari, L, and Heras, A

Subjects
Chitosan, Nanocomposite, Materiales, Structural Biology, General Medicine, Silver nanoparticles, Molecular Biology, Biochemistry, Química inorgánica
Abstract

In this study, water-soluble chitosan salts (chitosan amine sulfopropyl salts) were prepared from chitosan samples with different molecular weights and deacetylation degrees. These soluble-in-water polymer salts allowed us to produce, in an eco-friendly and facile method, silver nanoparticles (AgNPs) with better control on size and polydispersity, even at large silver concentrations than their corresponding chitosan sample. Chitosan salt-based materials (films and scaffolds) were analyzed in terms of antibacterial properties against Staphylococcus aureus ATCC23915 or Pseudomonas aeruginosa ATCC 27853. 3D scaffolds enhanced the effect of the chitosan-AgNPs combination compared to the equivalent films.

Published
2023

9. Assessment of ultra-short heart variability indices derived by smartphone accelerometers for stress detection

Author

Landreani, F, Faini, A, Martin-Yebra, A, Morri, M, Parati, G, Caiani, E, Landreani F., Faini A., Martin-Yebra A., Morri M., Parati G., Caiani E. G., Landreani, F, Faini, A, Martin-Yebra, A, Morri, M, Parati, G, Caiani, E, Landreani F., Faini A., Martin-Yebra A., Morri M., Parati G., and Caiani E. G.

Abstract

Body acceleration due to heartbeat-induced reaction forces can be measured as mobile phone accelerometer (m-ACC) signals. Our aim was to test the feasibility of using m-ACC to detect changes induced by stress by ultra-short heart rate variability (USV) indices (standard deviation of normal-to-normal interval—SDNN and root mean square of successive differences—RMSSD). Sixteen healthy volunteers were recruited; m-ACC was recorded while in supine position, during spontaneous breathing at rest conditions (REST) and during one minute of mental stress (MS) induced by arithmetic serial subtraction task, simultaneous with conventional electrocardiogram (ECG). Beat occurrences were extracted from both ECG and m-ACC and used to compute USV indices using 60, 30 and 10s durations, both for REST and MS. A feasibility of 93.8% in the beat-to-beat m-ACC heart rate series extraction was reached. In both ECG and m-ACC series, compared to REST, in MS the mean beat duration was reduced by 15% and RMSSD decreased by 38%. These results show that short term recordings (up to 10 s) of cardiac activity using smartphone’s accelerometers are able to capture the decrease in parasympathetic tone, in agreement with the induced stimulus.

Published
2019

10. Latent tuberculosis infection in patients with chronic plaque psoriasis: evidence from the Italian Psocare Registry*

Author

Gisondi, P., Cazzaniga, S., Chimenti, S., Maccarone, M., Picardo, M., Girolomoni, G., Naldi, L., Griseta, V., Miracapillo, A., Azzini, M., Mocci, L., Michelini, M., Offidani, A., Bernardini, L., Campanati, A., Ricotti, G., Giacchetti, A., Norat, M., Gualco, F., Castelli, A., Cuccia, A., Diana, A., Roncarolo, G., Belli, M. A., Baldassarre, M. A., Santoro, G., Vena, G. A., Lo Console, F., Filotico, R., Mastrandrea, V., Brunetti, B., Musumeci, F., Carrabba, E., Dal Mas, P., Annicchiarico, F., Benvegnù, B., Spaziani, G., Cusano, F., Iannazzone, Saletta S., Galluccio, A., Pezza, M., Marchesi, L., Imberti, G., Reseghetti, A., Barbera, C., Reggiani, M., Lanzoni, A., Patrizi, A., Bardazzi, F., Antonucci, A., De Tommaso, S., Balestri, R., Wallnofer, W., Ingannamorte, F., Calzavara-Pinton, P., Iannazzi, S., Zane, C., Capezzera, R., Bassisi, S., Rossi, M. T., Altamura, V., Vigl, W., Nobile, C., Aste, N., Murgia, S., Mugheddu, C., Scuderi, G., Baglieri, F., Di Dio, C., Grilli, Cilioni E., Mastronardi, C., Agnusdei, C. P., Antrilli, A., Aulisa, L., Raimondo, U., di Luzio, Scotto G., Battarra, V. C., Farro, P., Plaitano, R., Micali, G., Musumeci, M. L., Massimino, D., Li Calzi, M., La Greca, S., Pettinato, M., Sapienza, G., Valenti, G., De Giacomo, P. F., dʼAmico, D., Arcangeli, F., Brunelli, D., Ghetti, E., Tulli, A., Assi, G., Laria, G., Prestinari, F., Spadafora, S., Coppola, M., Caresana, G., Pezzarossa, E., Domaneschi, E., Felisi, C., Donato, L., Bertero, M., Musso, L., Pa lazzini, S., Bruscino, P., Agozzino, U. C., Ottaviani, M., Simoncini, C., Virgili, A., Osti, F., Fabbri, P., Volpi, W., Caproni, M., Lotti, T., Prignano, F., Buggiani, G., Troiano, M., Fenizi, G., Altobella, A., Amoruso, A., Condello, M., Goffredo, A., Righini, M. G., Alessandrini, F., Satolli, F., Zampetti, M., Bertani, E., Fossati, S., Parodi, A., Burlando, M., Fiorucci, C., Nigro, A., Ghigliotti, G., Massone, L., Moise, G. M., Serrai, M., Cannata, G., Campagnoli, A. M., Daly, M., Leporati, C., Peila, R., Filosa, G., Bugatti, L., Nicolini, M., Nazzari, G., Cestari, R., Anastasio, F., Larussa, F. M., Pollice, N., De Francesco, F., Mazzocchetti, G., Peris, K., Fargnoli, M. C., Di Cesare, A., De Angelis, L., Flati, G., Biamonte, A. S., Quarta, G., Congedo, M., Carcaterra, A., Strippoli, D., Fideli, D., Marsili, F., Celli, M., Ceccarini, M., Bachini, L., DʼOria, M., Schirripa, V., De Filippi, C., Martini, P., Lapucci, E., Mazzatenta, C., Ghilardi, A., Simonacci, M., Bettacchi, A., Gasco, R., Zanca, A., Battistini, S., Dattola, S., Vernaci, R., Postorino, F., Zampieri, P. F., Padovan, C., González Intchaurraga, M. A., Ladurner, J., Guarneri, B., Cannavò, S., Manfrè, C., Borgia, F., Guerra, Puglisi A., Sedona, P., Cattaneo, A., Carrera, C., Fracchiolla, C., Mozzanica, N., Prezzemolo, L., Menni, S., Lodi, A., Martino, P., Monti, M., Mancini, L., Sacrini, F., Altomare, G. F., Taglioni, M., Lovati, C., Mercuri, S. R., Schiesari, G., Giannetti, A., Conti, A., Lasagni, C., Greco, M., Ronsini, G., Schianchi, S., Fiorentini, C., Niglietta, S., Maglietta, R., Padalino, C., Crippa, D., Pini, M., Rossi, E., Tosi, D., Armas, M., Ruocco, V., Ayala, F., Balato, N., Gaudiello, F., Cimmino, G. F., Monfrecola, G., Gallo, L., Argenziano, G., Fulgione, E., Berruti, G., Mozzillo, R., Ceparano, S., De Michele, I., Giorgiano, D., Leigheb, G., Deledda, S., Peserico, A., Alaibac, M., Piaserico, S., Schiesari, L., Dan, G., Mattei, I., Oro, E., Aricò, M., Bongiorno, M. R., Angileri, R., Amato, S., Todaro, F., Milioto, M., Bellastro, R., Di Nuzzo, S., De Panfilis, G., Zanni, M., Borroni, G., Cananzi, R., Brazzelli, V., Lisi, P., Stingeni, L., Hansel, K., Pierfelice, V., Donelli, S., Rastelli, D., Gasperini, M., Barachini, P., Cecchi, R., Bartoli, L., Pavesi, M., De Paola, S., Corradin, M. T., Ricciuti, F., Piccirillo, A., Viola, L., Tataranni, M., Mautone, M. G., Lo Scocco, G., Niccoli, M. C., Brunasso Vernetti, A. M.G., Gaddoni, G., Resta, F., Casadio, M. C., Arcidiaco, M. C., Luvarà, M. C., Albertini, G., Di Lernia, V., Guareschi, E., Catrani, S., Morri, M., Amerio, P., De Simone, C., DʼAgostino, M., Agostino, I., Calvieri, S., Cantoresi, F., Richetta, A., Sorgi, P., Carnevale, C., Nicolucci, F., Berardesca, E., Ardigò, M., De Felice, C., Gubinelli, E., Talamonti, M., Camplone, G., Cruciani, G., Riccardi, F., Barbati, R., Pagani, W., Malagoli, P. G., Pellicano, R., Donadio, D., Di Vito, C., Cottoni, F., Montesu, M. A., Pirodda, C., Addis, G., Marongiu, P., Farris, A., Cacciapuoti, M., Verrini, A., Desirello, G., Gnone, M., Fimiani, M., Pellegrino, M., Castelli, G., Zappalà, L., Sesana, G., Ingordo, V., Vozza, E., Di Giuseppe, D., Fasciocco, D., Nespoli, P., Papini, M., Cicoletti, M., Bernengo, M. G., Ortoncelli, M., Bonvicino, A., Capella, G., Doveil, G. C., Forte, M., Peroni, A., Salomone, B., Savoia, P., Pippione, M., Zichichi, L., Frazzitta, M., De Luca, G., Tasin, L., Simonetto, D., Ros, S., Trevisan, G., Patamia, M., Miertusova, S., Patrone, P., Frattasio, A., Piccirillo, F., La Spina, S., Di Gaetano, L., Marzocchi, V., Motolese, A., Venturi, C., Gai, F., Pasquinucci, S., Bellazzi, R. M., Silvestri, T., Fornasa, Veller C., and Trevisan, G. P.

Published
2015
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11. Pruritus characteristics in a large Italian cohort of psoriatic patients

Author

Damiani, G., Cazzaniga, S., Conic, R. R. Z., Naldi, L., Griseta, V., Miracapillo, A., Azzini, M., Mocci, L., Michelini, M., Offidani, A., Bernardini, L., Campanati, A., Ricotti, G., Giacchetti, A., Norat, M., Gualco, F., Castelli, A., Cuccia, A., Diana, A., Roncarolo, G., Belli, M. A., Baldassarre, M. A., Santoro, G., Vena, G. A., Lo Console, F., Filotico, R., Mastrandrea, V., Brunetti, B., Musumeci, F., Carrabba, E., Dal Mas, P., Annicchiarico, F., Benvegnu, B., Spaziani, G., Cusano, F., Saletta Iannazzone, S., Galluccio, A., Pezza, M., Marchesi, L., Imberti, G., Reseghetti, A., Barbera, C., Reggiani, M., Lanzoni, A., Patrizi, A., Bardazzi, F., Antonucci, A., De Tommaso, S., Wallnofer, W., Ingannamorte, F., Calzavara-Pinton, P., Iannazzi, S., Zane, C., Capezzera, R., Bassisi, S., Rossi, M. T., Altamura, V., Vigl, W., Nobile, C., Aste, N., Murgia, S., Mugheddu, C., Scuderi, G., Baglieri, F., Di Dio, C., Cilioni Grilli, E., Mastronardi, C., Agnusdei, C. P., Antrilli, A., Aulisa, L., Raimondo, U., Scotto di Luzio, G., Battarra, V. C., Farro, P., Plaitano, R., Micali, G., Musumeci, M. L., Massimino, D., Li Calzi, M., La Greca, S., Pettinato, M., Sapienza, G., Valenti, G., De Giacomo, P. F., Amico, Arcangeli, F., Brunelli, D., Ghetti, E., Tulli, A., Assi, G., Amerio, P., Laria, G., Prestinari, F., Spadafora, S., Coppola, M., Caresana, G., Pezzarossa, E., Felisi, C., Donato, L., Bertero, M., Musso, L., Pa lazzini, S., Bruscino, P., Agozzino, U. C., Ottaviani, M., Simoncini, C., Virgili, A., Osti, F., Fabbri, P., Volpi, W., Caproni, M., Lotti, T., Prignano, F., Buggiani, G., Troiano, M., Fenizi, G., Altobella, A., Amoruso, A., Condello, M., Goffredo, A., Righini, M. G., Alessandrini, F., Satolli, F., Zampetti, M., Bertani, E., Fossati, S., Parodi, A., Burlando, M., Fiorucci, C., Nigro, A., Ghigliotti, G., Massone, L., Moise, G. M., Serrai, M., Cannata, G., Campagnoli, A. M., Daly, M., Leporati, C., Peila, R., Filosa, G., Bugatti, L., Nicolini, M., Nazzari, G., Cestari, R., Anastasio, F., Larussa, F. M., Pollice, N., De Francesco, F., Mazzocchetti, G., Peris, K., Fargnoli, M. C., Di Cesare, A., De Angelis, L., Flati, G., Biamonte, A. S., Quarta, G., Congedo, M., Carcaterra, A., Strippoli, D., Fideli, D., Marsili, F., Celli, M., Ceccarini, M., Bachini, L., D'Oria, M., Schirripa, V., De Filippi, C., Martini, P., Lapucci, E., Mazzatenta, C., Ghilardi, A., Simonacci, M., Bettacchi, A., Gasco, R., Zanca, A., Battistini, S., Dattola, S., Vernaci, R., Postorino, F., Zampieri, P. F., Padovan, C., Gonzalez Intchaurraga, M. A., Ladurner, J., Guarneri, B., Cannavo, S., Manfre, C., Borgia, F., Puglisi Guerra, A., Cattaneo, A., Carrera, C., Fracchiolla, C., Mozzanica, N., Prezzemolo, L., Menni, S., Lodi, A., Martino, P., Monti, M., Mancini, L., Sacrini, F., Altomare, G. F., Taglioni, M., Lovati, C., Mercuri, S. R., Schiesari, G., Giannetti, A., Conti, A., Lasagni, C., Greco, M., Ronsini, G., Schianchi, S., Fiorentini, C., Niglietta, S., Maglietta, R., Padalino, C., Crippa, D., Pini, M., Rossi, E., Tosi, D., Armas, M., Ruocco, V., Ayala, F., Balato, N., Gaudiello, F., Cimmino, G. F., Monfrecola, G., Gallo, L., Argenziano, G., Fulgione, E., Berruti, G., Ceparano, S., De Michele, I., Giorgiano, D., Leigheb, G., Deledda, S., Peserico, A., Alaibac, M., Piaserico, S., Schiesari, L., Dan, G., Mattei, I., Oro, E., Arico, M., Bongiorno, M. R., Angileri, R., Amato, S., Todaro, F., Milioto, M., Bellastro, R., Di Nuzzo, S., De Panfilis, G., Zanni, M., Borroni, G., Cananzi, R., Brazzelli, V., Lisi, P., Stingeni, L., Hansel, K., Pierfelice, V., Donelli, S., Rastelli, D., Gasperini, M., Barachini, P., Cecchi, R., Bartoli, L., Pavesi, M., De Paola, S., Corradin, M. T., Ricciuti, F., Piccirillo, A., Viola, L., Tataranni, M., Mautone, M. G., Lo Scocco, G., Niccoli, M. C., Brunasso Vernetti, A. M. G., Gaddoni, G., Resta, F., Casadio, M. C., Arcidiaco, M. C., Luvara, M. C., Albertini, G., Di Lernia, V., Guareschi, E., Catrani, S., Morri, M., De Simone, C., D'Agostino, M., Agostino, I., Calvieri, S., Cantoresi, F., Richetta, A., Sorgi, P., Carnevale, C., Nicolucci, F., Berardesca, E., Ardigo, M., De Felice, C., Gubinelli, E., Talamonti, M., Camplone, G., Cruciani, G., Riccardi, F., Barbati, R., Zumiani, G., Pagani, W., Malagoli, P. G., Pellicano, R., Donadio, D., Di Vito, C., Cottoni, F., Montesu, M. A., Pirodda, C., Addis, G., Marongiu, P., Farris, A., Cacciapuoti, M., Verrini, A., Desirello, G., Gnone, M., Fimiani, M., Pellegrino, M., Castelli, G., Zappala, L., Sesana, G., Ingordo, V., Vozza, E., Di Giuseppe, D., Fasciocco, D., Nespoli, P., Papini, M., Cicoletti, M., Bernengo, M. G., Ortoncelli, M., Bonvicino, A., Capella, G., Doveil, G. C., Forte, M., Peroni, A., Salomone, B., Savoia, P., Pippione, M., Zichichi, L., Frazzitta, M., De Luca, G., Tasin, L., Simonetto, D., Ros, S., Trevisan, G., Patamia, M., Miertusova, S., Patrone, P., Frattasio, A., Piccirillo, F., La Spina, S., Di Gaetano, L., Marzocchi, V., Motolese, A., Venturi, C., Gai, F., Pasquinucci, S., Bellazzi, R. M., Silvestri, T., Girolomoni, G., Gisondi, P., Veller Fornasa, C., Trevisan, G. P., Damiani G., Cazzaniga S., Conic R.R.Z., Naldi L., Griseta V., Miracapillo A., Azzini M., Mocci L., Michelini M., Offidani A., Bernardini L., Campanati A., Ricotti G., Giacchetti A., Norat M., Gualco F., Castelli A., Cuccia A., Diana A., Roncarolo G., Belli M.A., Baldassarre M.A., Santoro G., Vena G.A., Lo Console F., Filotico R., Mastrandrea V., Brunetti B., Musumeci F., Carrabba E., Dal Mas P., Annicchiarico F., Benvegnu B., Spaziani G., Cusano F., Saletta Iannazzone S., Galluccio A., Pezza M., Marchesi L., Imberti G., Reseghetti A., Barbera C., Reggiani M., Lanzoni A., Patrizi A., Bardazzi F., Antonucci A., De Tommaso S., Wallnofer W., Ingannamorte F., Calzavara-Pinton P., Iannazzi S., Zane C., Capezzera R., Bassisi S., Rossi M.T., Altamura V., Vigl W., Nobile C., Aste N., Murgia S., Mugheddu C., Scuderi G., Baglieri F., Di Dio C., Cilioni Grilli E., Mastronardi C., Agnusdei C.P., Antrilli A., Aulisa L., Raimondo U., Scotto di Luzio G., Battarra V.C., Farro P., Plaitano R., Micali G., Musumeci M.L., Massimino D., Li Calzi M., La Greca S., Pettinato M., Sapienza G., Valenti G., De Giacomo P.F., Amico, Arcangeli F., Brunelli D., Ghetti E., Tulli A., Assi G., Amerio P., Laria G., Prestinari F., Spadafora S., Coppola M., Caresana G., Pezzarossa E., Felisi C., Donato L., Bertero M., Musso L., Pa lazzini S., Bruscino P., Agozzino U.C., Ottaviani M., Simoncini C., Virgili A., Osti F., Fabbri P., Volpi W., Caproni M., Lotti T., Prignano F., Buggiani G., Troiano M., Fenizi G., Altobella A., Amoruso A., Condello M., Goffredo A., Righini M.G., Alessandrini F., Satolli F., Zampetti M., Bertani E., Fossati S., Parodi A., Burlando M., Fiorucci C., Nigro A., Ghigliotti G., Massone L., Moise G.M., Serrai M., Cannata G., Campagnoli A.M., Daly M., Leporati C., Peila R., Filosa G., Bugatti L., Nicolini M., Nazzari G., Cestari R., Anastasio F., Larussa F.M., Pollice N., De Francesco F., Mazzocchetti G., Peris K., Fargnoli M.C., Di Cesare A., De Angelis L., Flati G., Biamonte A.S., Quarta G., Congedo M., Carcaterra A., Strippoli D., Fideli D., Marsili F., Celli M., Ceccarini M., Bachini L., D'Oria M., Schirripa V., De Filippi C., Martini P., Lapucci E., Mazzatenta C., Ghilardi A., Simonacci M., Bettacchi A., Gasco R., Zanca A., Battistini S., Dattola S., Vernaci R., Postorino F., Zampieri P.F., Padovan C., Gonzalez Intchaurraga M.A., Ladurner J., Guarneri B., Cannavo S., Manfre C., Borgia F., Puglisi Guerra A., Cattaneo A., Carrera C., Fracchiolla C., Mozzanica N., Prezzemolo L., Menni S., Lodi A., Martino P., Monti M., Mancini L., Sacrini F., Altomare G.F., Taglioni M., Lovati C., Mercuri S.R., Schiesari G., Giannetti A., Conti A., Lasagni C., Greco M., Ronsini G., Schianchi S., Fiorentini C., Niglietta S., Maglietta R., Padalino C., Crippa D., Pini M., Rossi E., Tosi D., Armas M., Ruocco V., Ayala F., Balato N., Gaudiello F., Cimmino G.F., Monfrecola G., Gallo L., Argenziano G., Fulgione E., Berruti G., Ceparano S., De Michele I., Giorgiano D., Leigheb G., Deledda S., Peserico A., Alaibac M., Piaserico S., Schiesari L., Dan G., Mattei I., Oro E., Arico M., Bongiorno M.R., Angileri R., Amato S., Todaro F., Milioto M., Bellastro R., Di Nuzzo S., De Panfilis G., Zanni M., Borroni G., Cananzi R., Brazzelli V., Lisi P., Stingeni L., Hansel K., Pierfelice V., Donelli S., Rastelli D., Gasperini M., Barachini P., Cecchi R., Bartoli L., Pavesi M., De Paola S., Corradin M.T., Ricciuti F., Piccirillo A., Viola L., Tataranni M., Mautone M.G., Lo Scocco G., Niccoli M.C., Brunasso Vernetti A.M.G., Gaddoni G., Resta F., Casadio M.C., Arcidiaco M.C., Luvara M.C., Albertini G., Di Lernia V., Guareschi E., Catrani S., Morri M., De Simone C., D'Agostino M., Agostino I., Calvieri S., Cantoresi F., Richetta A., Sorgi P., Carnevale C., Nicolucci F., Berardesca E., Ardigo M., De Felice C., Gubinelli E., Talamonti M., Camplone G., Cruciani G., Riccardi F., Barbati R., Zumiani G., Pagani W., Malagoli P.G., Pellicano R., Donadio D., Di Vito C., Cottoni F., Montesu M.A., Pirodda C., Addis G., Marongiu P., Farris A., Cacciapuoti M., Verrini A., Desirello G., Gnone M., Fimiani M., Pellegrino M., Castelli G., Zappala L., Sesana G., Ingordo V., Vozza E., Di Giuseppe D., Fasciocco D., Nespoli P., Papini M., Cicoletti M., Bernengo M.G., Ortoncelli M., Bonvicino A., Capella G., Doveil G.C., Forte M., Peroni A., Salomone B., Savoia P., Pippione M., Zichichi L., Frazzitta M., De Luca G., Tasin L., Simonetto D., Ros S., Trevisan G., Patamia M., Miertusova S., Patrone P., Frattasio A., Piccirillo F., La Spina S., Di Gaetano L., Marzocchi V., Motolese A., Venturi C., Gai F., Pasquinucci S., Bellazzi R.M., Silvestri T., Girolomoni G., Gisondi P., Veller Fornasa C., and Trevisan G.P.

Subjects
Male, Cross-sectional study, Severity of Illness Index, Cohort Studies, 030207 dermatology & venereal diseases, 0302 clinical medicine, Risk Factors, education, itch, pruritus, psoriasis, pustular psoriasis, treatment, Adolescent, Adult, Cross-Sectional Studies, Educational Status, Facial Dermatoses, Female, Foot Dermatoses, Genitalia, Hand Dermatoses, Humans, Italy, Middle Aged, Pruritus, Psoriasis, Registries, Sex Factors, Young Adult, Epidemiology, Young adult, skin and connective tissue diseases, Settore MED/33 - MALATTIE APPARATO LOCOMOTORE, Infectious Diseases, 030220 oncology & carcinogenesis, Cohort, PRURITIS EPIDEMIOLOGY, Settore MED/35 - MALATTIE CUTANEE E VENEREE, Cohort study, medicine.medical_specialty, PSORIAS, Dermatology, Article, 03 medical and health sciences, Pharmacotherapy, Settore MED/35, Severity of illness, medicine, business.industry, medicine.disease, Pruritus,Itch sensation, business
Abstract

Background: Psoriasis (Ps) is a chronic systemic autoimmune disease associated with pruritus in 64–98% of patients. However, few modestly sized studies assess factors associated with psoriatic pruritus. Objective: To investigate factors associated with Ps pruritus intensity. Methods: Psoriasis patients 18years or older seen in one of 155 centres in Italy between September 2005 and 2009 were identified from the Italian PsoCare registry. Patients without cutaneous psoriasis and those with missed information on pruritus were excluded. Results: We identified 10802 patients, with a mean age 48.8±14.3years. Mild itch was present in 33.2% of patients, moderate in 34.4%, severe in 18.7% and very severe in 13.7%. Higher itch intensity was associated with female gender, lower educational attainment compared to university degree, pustular psoriasis, psoriasis on the head, face, palmoplantar areas, folds and genitalia, more severe disease, disease duration

Published
2019

12. A determination ofα s( $$M_{Z^0 } $$ ) at LEP using resummed QCD calculations

Author

Acton, P. D., Alexander, G., Allison, J., Allport, P. P., Anderson, K. J., Arcelli, S., Astbury, A., Axen, D., Azuelos, G., Bahan, G. A., Baines, J. T. M., Ball, A. H., Banks, J., Barlow, R. J., Barnett, S., Batley, J. R., Beaudoin, G., Beck, A., Beck, G. A., Becker, J., Behnke, T., Bell, K. W., Bella, G., Bentkowski, P., Berlich, P., Bethke, S., Biebel, O., Binder, U., Bloodworth, I. J., Bock, P., Boden, B., Bosch, H. M., Breuker, H., Bright-Thomas, P., Brown, R. M., Buijs, A., Burckhart, H. J., Burgard, C., Capiluppi, P., Carnegie, R. K., Carter, A. A., Carter, J. R., Chang, C. Y., Charlton, D. G., Chu, S. L., Clarke, P. E. L., Cohen, I., Clayton, J. C., Collins, W. J., Conboy, J. E., Cooper, M., Coupland, M., Cuffiani, M., Dado, S., Dallavalle, G. M., De Jong, S., del Pozo, L. A., Deng, H., Dieckmann, A., Dittmar, M., Dixit, M. S., do Couto e Silva, E., Duboscq, J. E., Duchovni, E., Duckeck, G., Duerdoth, I. P., Dumas, D. J. P., Elcombe, P. A., Estabrooks, P. G., Etzion, E., Evans, H. G., Fabbri, F., Fierro, M., Fincke-Keeler, M., Fischer, H. M., Fong, D. G., Foucher, M., Gaidot, A., Ganel, O., Gary, J. W., Gascon, J., McGowan, R. F., Geddes, N. I., Geich-Gimbel, C., Gensler, S. W., Gentit, F. X., Giacomelli, G., Giacomelli, R., Gibson, V., Gibson, W. R., Gillies, J. D., Goldberg, J., Goodrick, M. J., Gorn, W., Grandi, C., Grant, F. C., Hagemann, J., Hanson, G. G., Hansroul, M., Hargrove, C. K., Harrison, P. F., Hart, J., Hattersley, P. M., Hauschild, M., Hawkes, C. M., Heflin, E., Hemingway, R. J., Heuer, R. D., Hill, J. C., Hillier, S. J., Hilse, T., Hinshaw, D. A., Hobbs, J. D., Hobson, P. R., Hochman, D., Homer, R. J., Honma, A. K., Hughes-Jones, R. E., Humbert, R., Igo-Kemenes, P., Ihssen, H., Imrie, D. C., Janissen, A. C., Jawahery, A., Jeffreys, P. W., Jeremie, H., Jimack, M., Jobes, M., Jones, R. W. L., Jovanovic, P., Jui, C., Karlen, D., Kawagoe, K., Kawamoto, T., Keeler, R. K., Kellogg, R. G., Kennedy, B. W., Kluth, S., Kobayashi, T., Koetke, D. S., Kokott, T. P., Komamiya, S., Köpke, L., Kral, J. F., Kowalewski, R., von Krogh, J., Kroll, J., Kuwano, M., Kyberd, P., Lafferty, G. D., Lahmann, R., Lamarche, F., Layter, J. G., Leblanc, P., Lee, A. M., Lehto, M. H., Lellouch, D., Leroy, C., Letts, J., Levegrün, S., Levinson, L., Lloyd, S. L., Loebinger, F. K., Lorah, J. M., Lorazo, B., Losty, M. J., Lou, X. C., Ludwig, J., Manelli, M., Marcellini, S., Maringer, G., Markus, C., Martin, A. J., Martin, J. P., Mashimo, T., Mättig, P., Maur, U., McKenna, J., McMahon, T. J., McNutt, J. R., Meijers, F., Menszner, D., Merritt, F. S., Mes, H., Michelini, A., Middleton, R. P., Mikenberg, G., Mildenberger, J., Miller, D. J., Mir, R., Mohr, W., Moisan, C., Montanari, A., Mori, T., Morri, M., Mouthuy, T., Nellen, B., Nguyen, H. H., Nozaki, M., O'Neale, S. W., Oakham, F. G., Odorici, F., Ogren, H. O., Oram, C. J., Oreglia, M. J., Orito, S., Pansart, J. P., Panzer-Steindel, B., Paschievici, P., Patrick, G. N., Paz-Jaoshvili, N., Pfister, P., Pilcher, J. E., Pinfold, J., Pitman, D., Plane, D. E., Poffenberger, P., Poli, B., Pouladdej, A., Pritchard, T. W., Przysierzniak, H., Quast, G., Redmond, M. W., Rees, D. L., Richards, G. E., Robinson, D., Rollnik, A., Roney, J. M., Ros, E., Rossberg, S., Rossi, A. M., Rosvick, M., Routenburg, P., Runge, K., Runolfsson, O., Rust, D. R., Sasaki, M., Sbarra, C., Schaile, A. D., Schaile, O., Schappert, W., Scharff-Hansen, P., Schenk, P., Schmitt, B., von der Schmitt, H., Schreiber, S., Schwick, C., Schwiening, J., Scott, W. G., Settles, M., Shears, T. G., Shen, B. C., Shepherd-Themistocleous, C. H., Sherwood, P., Shypit, R., Simon, A., Singh, P., Siroli, G. P., Skuja, A., Smith, A. M., Smith, T. J., Snow, G. A., Sobie, R., Springer, R. W., Sproston, M., Stephens, K., Steuerer, J., Ströhmer, R., Strom, D., Takeshita, T., Taras, P., Tarem, S., Tecchio, M., Teixeira-Dias, P., Tesch, N., Thackray, N. J., Thomson, M. A., Torrente-Lujan, E., Transtromer, G., Tresilian, N. J., Tsukamoto, T., Turner, M. F., Tysarczyk-Niemeyer, G., Van den plas, D., Van Kooten, R., Van Dalen, G. J., Vasseur, G., Virtue, C. J., Wagner, A., Wagner, D. L., Wahl, C., Walker, J. P., Ward, C. P., Ward, D. R., Watkins, P. M., Watson, A. T., Watson, N. K., Weber, M., Weber, P., Wells, P. S., Wermes, N., Whalley, M. A., Wilson, G. W., Wilson, J. A., Winterer, V. -H., Wlodek, T., Wotton, S., Wyatt, T. R., Yaari, R., Yeaman, A., Yekutieli, G., Yurko, M., Zeuner, W., Zorn, G. T., and OPAL Collaboration

Published
1993
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15. Latent tubercolosis infection in patients with cronic plaque psoriasis: evidence from the Italian Psocare Registry

Author

Gisondi, P, Cazzaniga, S, Chimenti, S, Maccarone, M, Picardo, M, Girolomoni, G, Naldi, L, Griseta V, Psocare Study Group., Miracapillo, A, Azzini, M, Mocci, L, Michelini, M, Offidani, A, Bernardini, L, Campanati, A, Ricotti, G, Giacchetti, Alessandro, Norat, M, Gualco, F, Castelli, A, Cuccia, A, Diana, A, Roncarolo, G, Belli, Ma, Baldassarre, Ma, Santoro, G, Vena, Ga, Lo Console, F, Filotico, R, Mastrandrea, V, Brunetti, B, Musumeci, F, Carrabba, E, Dal Mas, P, Annicchiarico, F, Benvegnù, B, Spaziani, G, Cusano, F, Saletta Iannazzone, S, Galluccio, A, Pezza, M, Marchesi, L, Imberti, G, Reseghetti, A, Barbera, Claudia, Reggiani, Matteo, Lanzoni, A, Patrizi, A, Bardazzi, F, Antonucci, A, De Tommaso, S, Balestri, R, Wallnofer, W, Ingannamorte, F, Calzavara-Pinton, P, Iannazzi, S, Zane, C, Capezzera, R, Bassisi, S, Rossi, Mt, Altamura, V, Vigl, W, SCHETTINO NOBILE, Carla, Aste, N, Murgia, S, Mugheddu, C, Scuderi, G, Baglieri, F, Di Dio, C, Cilioni Grilli, E, Mastronardi, C, Agnusdei, Cp, Antrilli, A, Aulisa, L, Raimondo, U, Scotto di Luzio, G, Battarra, Vc, Farro, P, Plaitano, R, Micali, G, Musumeci, Ml, D'Armiento, Massimino, Li Calzi, M, LA GRECA, SEBASTIANO VITTORIO, Pettinato, Cristiana Maria, Sapienza, G, Valenti, G, De Giacomo PF, D'Amico, D, Arcangeli, Federica, Brunelli, D, Ghetti, E, Tulli, Augusta, Assi, G, Amerio, P, Laria, G, Prestinari, F, Spadafora, S, Coppola, M, Caresana, G, Pezzarossa, E, Domaneschi, E, Felisi, C, Donato, L, Bertero, M, Musso, L, Pa Lazzini, S, Bruscino, P, Agozzino, Uc, Ottaviani, M, Simoncini, Cristiana, Virgili, A, Osti, F, Fabbri, P, Volpi, Walter, Caproni, M, Lotti, T, Prignano, F, Buggiani, G, Troiano, M, Fenizi, G, Altobella, A, Amoruso, A, Condello, M, Goffredo, A, Righini, Mg, Alessandrini, F, Satolli, F, Zampetti, M, Bertani, E, Fossati, S, Parodi, A, Burlando, M, Fiorucci, C, Nigro, A, Ghigliotti, G, Massone, L, Moise, Gm, Serrai, M, Cannata, G, Campagnoli, Am, Daly, M, Leporati, C, Peila, R, Filosa, Giovanna, Bugatti, L, Nicolini, M, Nazzari, G, Cestari, R, Anastasio, Fabio, Larussa, Fm, Pollice, N, De Francesco, F, Mazzocchetti, G, Peris, K, Fargnoli, Mc, Di Cesare, A, De Angelis, L, Flati, G, Biamonte, As, Quarta, Giovanni, Congedo, M, Carcaterra, A, Strippoli, D, Fideli, D, Marsili, Filippo, Celli, M, Ceccarini, M, Bachini, L, D ORIA, MARIA FEDERICA, Schirripa, V, De Filippi, C, Martini, P, Lapucci, E, Mazzatenta, C, Ghilardi, A, Simonacci, M, Bettacchi, A, Gasco, R, Zanca, A, Battistini, Simone, Dattola, S, Vernaci, R, Postorino, F, Zampieri, Pf, Padovan, MARIA CRISTINA, González Intchaurraga MA, Ladurner, J, Guarneri, B, Cannavo', Serena, Manfrè, C, Borgia, F, Puglisi Guerra, A, Sedona, P, Cattaneo, A, Carrera, C, Fracchiolla, C, Mozzanica, N, Prezzemolo, L, Menni, S, Lodi, A, Martino, P, Monti, M, Mancini, L, Sacrini, F, Altomare, Gf, Taglioni, M, Lovati, C, Mercuri, Sr, Schiesari, G, Giannetti, A, Conti, A, Lasagni, C, Greco, M, Ronsini, G, Schianchi, S, Fiorentini, C, Niglietta, S, Miglietta, R, Padalino, C, Crippa, D, Pini, M, Rossi, E, Tosi, D, Armas, M, Ruocco, V, Ayala, F, Balato, N, Gaudiello, F, Cimmino, Gf, Monfrecola, G, Gallo, L, Argenziano, G, Fulgione, E, Berruti, G, Mozzillo, R, Ceparano, S, De Michele, I, Giorgiano, D, Leigheb, G, Deledda, S, Peserico, A, Alaibac, M, Piaserico, S, Schiesari, L, Dan, G, Mattei, I, Oro, E, Aricò, M, Bongiorno, Mr, Angileri, Rosalia, Amato, S, Todaro, F, Milioto, M, Bellastro, R, Di Nuzzo, S, De Panfilis, G, Zanni, M, Borroni, G, Cananzi, R, Brazzelli, V, Lisi, P, Stingeni, L, Hansel, K, Pierfelice, V, Donelli, S, Rastelli, D, Gasperini, M, Barachini, P, Cecchi, R, Bartoli, L, Pavesi, Maria Gabriella, De Paola, S, Corradin, Mt, Ricciuti, F, Piccirillo, Alessandro, Viola, L, Tataranni, M, Mautone, Mg, Lo Scocco, G, Niccoli, Mc, Brunasso Vernetti AM, Gaddoni, G, DI RESTA, Fabio, Casadio, Mc, Arcidiaco, Mc, Luvarà, Mc, ALBERTINI PETRONI, Guglielmo, DI LERNIA, Valerio, Guareschi, E, Catrani, S, Morri, M, De Simone, C, D'Agostino, M, Agostino, I, Calvieri, S, Cantoresi, F, Richetta, A, Sorgi, Paola, Carnevale, C, Nicolucci, F, Berardesca, E, Ardigò, M, De Felice, C, Gubinelli, E, Talamonti, Marina, Camplone, G, Cruciani, Giulio, Riccardi, F, Barbati, R, Zumiani, G, Pagani, W, Malagoli, Pg, Pellicano, R, Donadio, Diego, Di Vito, C, Cottoni, F, Montesu, Ma, Pirodda, C, Addis, G, Marongiu, P, Farris, A, Cacciapuoti, Anna Maria, Verrini, A, Desirello, G, Gnone, M, Fimiani, M, Pellegrino, M, Castelli, G, Zappalà, L, Sesana, G, Ingordo, V, Vozza, E, Di Giuseppe, D, Fasciocco, D, Nespoli, P, Papini, M, Cicoletti, M, Bernengo, Mg, Ortoncelli, M, Bonvicino, A, Capella, G, Doveil, Gc, Forte, M, Peroni, A, Salomone, B, Savoia, P, Pippione, M, Zichichi, Ludovica, Frazzitta, M, De Luca, G, Tasin, L, Simonetto, D, Ros, S, Trevisan, G, Patamia, M, Miertusova, S, Patrone, Pietro, Frattasio, A, Piccirillo, Fabiola, La Spina, S, Di Gaetano, L, Marzocchi, V, Motolese, A, Venturi, Caterina, Gai, Francesco, Pasquinucci, S, Bellazzi, Rm, Silvestri, Tommaso, Veller Fornasa, C, Trevisan, Gp., Gisondi, P, Cazzaniga, S, Chimenti, S, Maccarone, M, Picardo, M, Girolomoni, G, Naldi, L, the Psocare Study Group [.., Annalisa Patrizi, ], Trevisan, Giusto, Girolomoni, G., Maccarone, Sergio, Naldi, L., Gisondi, P., Cazzaniga, S., Chimenti, S., Maccarone, M., Picardo, M., Griseta, V., Miracapillo, A., Azzini, M., Mocci, L., Michelini, M., Offidani, A., Bernardini, L., Campanati, A., Ricotti, G., Giacchetti, A., Norat, M., Gualco, F., Castelli, A., Cuccia, A., Diana, A., Roncarolo, G., Belli, M.A., Baldassarre, M.A., Santoro, G., Vena, G.A., Lo Console, F., Filotico, R., Mastrandrea, V., Brunetti, B., Musumeci, F., Carrabba, E., Dal Mas, P., Annicchiarico, F., Benvegnù, B., Spaziani, G., Cusano, F., Saletta Iannazzone, S., Galluccio, A., Pezza, M., Marchesi, L., Imberti, G., Reseghetti, A., Barbera, C., Reggiani, M., Lanzoni, A., Patrizi, A., Bardazzi, F., Antonucci, A., De Tommaso, S., Balestri, R., Wallnofer, W., Ingannamorte, F., Calzavara-Pinton, P., Iannazzi, S., Zane, C., Capezzera, R., Bassisi, S., Rossi, M.T., Altamura, V., Vigl, W., Nobile, C., Aste, N., Murgia, S., Mugheddu, C., Scuderi, G., Baglieri, F., Di Dio, C., Cilioni Grilli, E., Mastronardi, C., Agnusdei, C.P., Antrilli, A., Aulisa, L., Raimondo, U., Scotto Di Luzio, G., Battarra, V.C., Farro, P., Plaitano, R., Micali, G., Musumeci, M.L., Massimino, D., Li Calzi, M., La Greca, S., Pettinato, M., Sapienza, G., Valenti, G., De Giacomo, P.F., D'Amico, D., Arcangeli, F., Brunelli, D., Ghetti, E., Tulli, A., Assi, G., Amerio, P., Laria, G., Prestinari, F., Spadafora, S., Coppola, M., Caresana, G., Pezzarossa, E., Domaneschi, E., Felisi, C., Donato, L., Bertero, M., Musso, L., Pa Lazzini, S., Bruscino, P., Agozzino, U.C., Ottaviani, M., Simoncini, C., Virgili, A., Osti, F., Fabbri, P., Volpi, W., Caproni, M., Lotti, T., Prignano, F., Buggiani, G., Troiano, M., Fenizi, G., Altobella, A., Amoruso, A., Condello, M., Goffredo, A., Righini, M.G., Alessandrini, F., Satolli, F., Zampetti, M., Bertani, E., Fossati, S., Parodi, A., Burlando, M., Fiorucci, C., Nigro, A., Ghigliotti, G., Massone, L., Moise, G.M., Serrai, M., Cannata, G., Campagnoli, A.M., Daly, M., Leporati, C., Peila, R., Filosa, G., Bugatti, L., Nicolini, M., Nazzari, G., Cestari, R., Anastasio, F., Larussa, F.M., Pollice, N., De Francesco, F., Mazzocchetti, G., Peris, K., Fargnoli, M.C., Di Cesare, A., De Angelis, L., Flati, G., Biamonte, A.S., Quarta, G., Congedo, M., Carcaterra, A., Strippoli, D., Fideli, D., Marsili, F., Celli, M., Ceccarini, M., Bachini, L., D'Oria, M., Schirripa, V., De Filippi, C., Martini, P., Lapucci, E., Mazzatenta, C., Ghilardi, A., Simonacci, M., Bettacchi, A., Gasco, R., Zanca, A., Battistini, S., Dattola, S., Vernaci, R., Postorino, F., Zampieri, P.F., Padovan, C., González Intchaurraga, M.A., Ladurner, J., Guarneri, B., Cannavò, S.P., Manfrè, C., Borgia, F., Puglisi Guerra, A., Sedona, P., Cattaneo, A., Carrera, C., Fracchiolla, C., Mozzanica, N., Prezzemolo, L., Menni, S., Lodi, A., Martino, P., Monti, M., Mancini, L., Sacrini, F., Altomare, G.F., Taglioni, M., Lovati, C., Mercuri, S.R., Schiesari, G., Giannetti, A., Conti, A., Lasagni, C., Greco, M., Ronsini, G., Schianchi, S., Fiorentini, C., Niglietta, S., Maglietta, R., Padalino, C., Crippa, D., Pini, M., Rossi, E., Tosi, D., Armas, M., Ruocco, V., Ayala, F., Balato, N., Gaudiello, F., Cimmino, G.F., Monfrecola, G., Gallo, L., Argenziano, G., Fulgione, E., Berruti, G., Mozzillo, R., Ceparano, S., De Michele, I., Giorgiano, D., Leigheb, G., Deledda, S., Peserico, A., Alaibac, M., Piaserico, S., Schiesari, L., Dan, G., Mattei, I., Oro, E., Aricò, M., Bongiorno, M.R., Angileri, R., Amato, S., Todaro, F., Milioto, M., Bellastro, R., Di Nuzzo, S., De Panfilis, G., Zanni, M., Borroni, G., Cananzi, R., Brazzelli, V., Lisi, P., Stingeni, L., Hansel, K., Pierfelice, V., Donelli, S., Rastelli, D., Gasperini, M., Barachini, P., Cecchi, R., Bartoli, L., Pavesi, M., De Paola, S., Corradin, M.T., Ricciuti, F., Piccirillo, A., Viola, L., Tataranni, M., Mautone, M.G., Lo Scocco, G., Niccoli, M.C., Brunasso Vernetti, A.M.G., Gaddoni, G., Resta, F., Casadio, M.C., Arcidiaco, M.C., Luvarà, M.C., Albertini, G., Di Lernia, V., Guareschi, E., Catrani, S., Morri, M., De Simone, C., D'Agostino, M., Agostino, I., Calvieri, S., Cantoresi, F., Richetta, A., Sorgi, P., Carnevale, C., Nicolucci, F., Berardesca, E., Ardigò, M., De Felice, C., Gubinelli, E., Talamonti, M., Camplone, G., Cruciani, G., Riccardi, F., Barbati, R., Zumiani, G., Pagani, W., Malagoli, P.G., Pellicano, R., Donadio, D., Di Vito, C., Cottoni, F., Montesu, M.A., Pirodda, C., Addis, G., Marongiu, P., Farris, A., Cacciapuoti, M., Verrini, A., Desirello, G., Gnone, M., Fimiani, M., Pellegrino, M., Castelli, G., Zappalà, L., Sesana, G., Ingordo, V., Vozza, E., Di Giuseppe, D., Fasciocco, D., Nespoli, P., Papini, M., Cicoletti, M., Bernengo, M.G., Ortoncelli, M., Bonvicino, A., Capella, G., Doveil, G.C., Forte, M., Peroni, A., Salomone, B., Savoia, P., Pippione, M., Zichichi, L., Frazzitta, M., De Luca, G., Tasin, L., Simonetto, D., Ros, S., Trevisan, G., Patamia, M., Miertusova, S., Patrone, P., Frattasio, A., Piccirillo, F., La Spina, S., Di Gaetano, L., Marzocchi, V., Motolese, A., Venturi, C., Gai, F., Pasquinucci, S., Bellazzi, R.M., Silvestri, T., Veller Fornasa, C., and Trevisan, G.P.

Subjects
Registrie, Male, taiwan, Antitubercular Agents, Biological Factor, quantiferon-tb-gold, Antitubercular Agent, Biological Factors, experience, Residence Characteristics, 80 and over, Prevalence, Registries, Young adult, risk, Aged, 80 and over, Latent Tuberculosi, Latent tuberculosis, psoriasis, Middle Aged, Italy, Female, tubercolosis, tubercolosi, Adolescent, Adult, Age Distribution, Aged, Chronic Disease, Humans, Latent Tuberculosis, PUVA Therapy, Psoriasis, Sex Distribution, Tuberculin Test, Young Adult, 2708, Human, medicine.drug, medicine.medical_specialty, chronic plaque psoriasis, Tuberculin, consensus statement, Dermatology, tuberculosis infection, Settore MED/35, Internal medicine, medicine, Adalimumab, factor antagonists, necrosis-factor blockers, systemic treatment, therapy, assay, Psoriasi, History of tuberculosis, tuberculosis infection, chronic plaque psoriasis,Italian Psocare Registry, business.industry, Odds ratio, medicine.disease, bacterial infections and mycoses, Confidence interval, Surgery, Residence Characteristic, Italian Psocare Registry, business
Abstract

SummaryBackground The nationwide prevalence of latent tuberculosis infection (LTBI) in Italian patients with psoriasis has never been investigated. Objectives To estimate the nationwide prevalence of LTBI in Italian patients with psoriasis who are candidates for systemic treatment. Methods Data were obtained from the Psocare Registry on those patients (n = 4946) with age > 18 years, systemic treatment at entry specified and tuberculin skin test (TST) performed according to the Mantoux method. LTBI diagnosis was based on a positive TST result in the absence of any clinical, radiological or microbiological evidence of active tuberculosis. Results Latent tuberculosis infection was diagnosed in 8·3% of patients with psoriasis (409 of 4946). The prevalence of LTBI was lower in patients on biologics than in those on conventional systemic treatments, ranging from 4·3% (19 of 444) of patients on adalimumab to 31% (eight of 26) of those on psoralen–ultraviolet A (P

Published
2015

16. Efficacy of switching between tumor necrosis factor-alfa inhibitors in psoriasis: results from the Italian Psocare registry

Author

Piaserico, Stefano, Cazzaniga, Simone, Chimenti, Sergio, Giannetti, Alberto, Maccarone, Mara, Picardo, Mauro, Peserico, Andrea, Naldi, Luigi, Griseta, V., Miracapillo, A., Azzini, M., Mocci, L., Michelini, M., Offidani, A., Bernardini, L., Campanati, A., Ricotti, G., Giacchetti, A., Norat, M., Gualco, F., Castelli, A., Cuccia, A., Diana, A., Roncarolo, G., Belli, M. A., Baldassarre, M. A., Santoro, G., Vena, G. A., Lo Console, F., Filotico, R., Mastrandrea, V., Brunetti, B., Musumeci, F., Carrabba, E., Dal Mas, P., Annicchiarico, F., Benvegnã¹, B., Spaziani, G., Cusano, F., Saletta Iannazzone, S., Galluccio, A., Pezza, M., Marchesi, L., Imberti, G., Reseghetti, A., Barbera, C., Reggiani, M., Lanzoni, A., Patrizi, A., Bardazzi, F., Antonucci, A., De Tommaso, S., Balestri, R., Wallnofer, W., Ingannamorte, F., Calzavara-Pinton, P., Iannazzi, S., Zane, C., Capezzera, R., Bassisi, S., Rossi, M. T., Altamura, V., Vigl, W., Nobile, C., Aste, N., Murgia, S., Mugheddu, C., Scuderi, G., Baglieri, F., Di Dio, C., Cilioni Grilli, E., Mastronardi, C., Agnusdei, C. P., Antrilli, A., Aulisa, L., Raimondo, U., Scotto di Luzio, G., Battarra, V. C., Farro, P., Plaitano, R., Micali, G., Musumeci, M. L., Massimino, D., Li Calzi, M., La Greca, S., Pettinato, M., Sapienza, G., Valenti, G., De Giacomo, P. F., D’amico, D., Arcangeli, F., Brunelli, D., Ghetti, E., Tulli, A., Assi, G., Amerio, P., Laria, G., Prestinari, F., Spadafora, S., Coppola, M., Caresana, G., Pezzarossa, E., Domaneschi, E., Felisi, C., Donato, L., Bertero, M., Musso, L., Pa lazzini, S., Bruscino, P., Agozzino, U. C., Ottaviani, M., Simoncini, C., Virgili, A., Osti, F., Fabbri, P., Volpi, W., Caproni, M., Lotti, T., Prignano, F., Buggiani, G., Troiano, M., Fenizi, G., Altobella, A., Amoruso, A., Condello, M., Goffredo, A., Righini, M. G., Alessandrini, F., Satolli, F., Zampetti, M., Bertani, E., Fossati, S., Parodi, A., Burlando, M., Fiorucci, C., Nigro, A., Ghigliotti, G., Massone, L., Moise, G. M., Serrai, M., Cannata, G., Campagnoli, A. M., Daly, M., Leporati, C., Peila, R., Filosa, G., Bugatti, L., Nicolini, M., Nazzari, G., Cestari, R., Anastasio, F., Larussa, F. M., Pollice, N., De Francesco, F., Mazzocchetti, G., Peris, K., Fargnoli, M. C., Di Cesare, A., De Angelis, L., Flati, G., Biamonte, A. S., Quarta, G., Congedo, M., Carcaterra, A., Strippoli, D., Fideli, D., Marsili, F., Celli, M., Ceccarini, M., Bachini, L., D’oria, M., Schirripa, V., De Filippi, C., Martini, P., Lapucci, E., Mazzatenta, C., Ghilardi, A., Simonacci, M., Bettacchi, A., Gasco, R., Zanca, A., Battistini, S., Dattola, S., Vernaci, R., Postorino, F., Zampieri, P. F., Padovan, C., González Intchaurraga, M. A., Ladurner, J., Guarneri, B., Cannavo', S., Manfrã, C., Borgia, F., Puglisi Guerra, A., Sedona, P., Cattaneo, A., Carrera, C., Fracchiolla, C., Mozzanica, N., Prezzemolo, L., Menni, S., Lodi, A., Martino, P., Monti, M., Mancini, L., Sacrini, F., Altomare, G. F., Taglioni, M., Lovati, C., Mercuri, S. R., Schiesari, G., Giannetti, A., Conti, A., Lasagni, C., Greco, M., Ronsini, G., Schianchi, S., Fiorentini, C., Niglietta, S., Maglietta, R., Padalino, C., Crippa, D., Pini, M., Rossi, E., Tosi, D., Armas, M., Ruocco, V., Ayala, F., Balato, N., Gaudiello, F., Cimmino, G. F., Monfrecola, G., Gallo, L., Argenziano, G., Fulgione, E., Berruti, G., Ceparano, S., De Michele, I., Giorgiano, D., Leigheb, G., Deledda, S., Peserico, A., Alaibac, M., Piaserico, S., Schiesari, L., Dan, G., Mattei, I., Oro, E., Aricã², M., Bongiorno, M. R., Angileri, R., Amato, S., Todaro, F., Milioto, M., Bellastro, R., Di Nuzzo, S., De Panfilis, G., Zanni, M., Borroni, G., Cananzi, R., Brazzelli, V., Lisi, P., Stingeni, L., Hansel, K., Pierfelice, V., Donelli, S., Rastelli, D., Gasperini, M., Barachini, P., Cecchi, R., Bartoli, L., Pavesi, M., De Paola, S., Corradin, M. T., Ricciuti, F., Piccirillo, A., Viola, L., Tataranni, M., Mautone, M. G., Lo Scocco, G., Niccoli, M. C., Brunasso Vernetti, A. M. G., Gaddoni, G., Resta, F., Casadio, M. C., Arcidiaco, M. C., Luvarã , M. C., Albertini, G., Di Lernia, V., Guareschi, E., Catrani, S., Morri, M., De Simone, C., D’agostino, M., Agostino, I., Calvieri, S., Cantoresi, F., Richetta, A., Sorgi, P., Carnevale, C., Nicolucci, F., Berardesca, E., Ardigã², M., De Felice, C., Gubinelli, E., Chimenti, S., Talamonti, M., Camplone, G., Cruciani, G., Riccardi, F., Barbati, R., Zumiani, G., Pagani, W., Malagoli, P. G., Pellicano, R., Donadio, D., Di Vito, C., Cottoni, F., Montesu, M. A., Pirodda, C., Addis, G., Marongiu, P., Farris, A., Cacciapuoti, M., Verrini, A., Desirello, G., Gnone, M., Fimiani, M., Pellegrino, M., Castelli, G., Zappalã , L., Sesana, G., Ingordo, V., Vozza, E., Di Giuseppe, D., Fasciocco, D., Nespoli, P., Papini, M., Cicoletti, M., Bernengo, M. G., Ortoncelli, M., Bonvicino, A., Capella, G., Doveil, G. C., Forte, M., Peroni, A., Salomone, B., Savoia, P., Pippione, M., Zichichi, L., Frazzitta, M., De Luca, G., Tasin, L., Simonetto, D., Ros, S., Trevisan, G., Patamia, M., Miertusova, S., Patrone, P., Frattasio, A., Piccirillo, F., La Spina, S., Di Gaetano, L., Marzocchi, V., Motolese, A., Venturi, C., Gai, F., Pasquinucci, S., Bellazzi, R. M., Silvestri, T., Girolomoni, G., Gisondi, P., Veller Fornasa, C., Trevisan, G. P., Piaserico S, Cazzaniga S, Chimenti S, Giannetti A, Maccarone M, Picardo M, Peserico A, Naldi L, Psocare Study Group [.., Patrizi A, ], Piaserico, S, Cazzaniga, S, Chimenti, S, Giannetti, A, Maccarone, M, Picardo, M, Peserico, A, Naldi, L, Bongiorno, MR, Psocare Study Group, Monfrecola, Giuseppe, and Trevisan, Giusto

Subjects
Male, primary inefficacy, 75% improvement in the Psoriasis Area Severity Index score, PASI, PASI 75, Psoriasis Area Severity Index, TNF, biologics, efficacy, psoriasis, secondary loss of efficacy, switching, tumor necrosis factor, tumor necrosis factor-alfa inhibitors, Adult, Analysis of Variance, Antibodies, Monoclonal, Antibodies, Monoclonal, Humanized, Cohort Studies, Confidence Intervals, Dose-Response Relationship, Drug, Drug Administration Schedule, Female, Follow-Up Studies, Humans, Immunoglobulin G, Italy, Middle Aged, Multivariate Analysis, Predictive Value of Tests, Proportional Hazards Models, Psoriasis, Receptors, Tumor Necrosis Factor, Registries, Retrospective Studies, Risk Assessment, Severity of Illness Index, Treatment Outcome, Tumor Necrosis Factor-alpha, Young Adult, SWITHCES, psoriasis arthritis, pharmachological treatment, Etanercept, Monoclonal, Receptors, Settore MED/35 - Malattie Cutanee E Veneree, Humanized, Hazard ratio, Predictive value of tests, Drug, biologic, TNF-alpha, medicine.medical_specialty, Dermatology, Antibodies, Dose-Response Relationship, Settore MED/35, Internal medicine, Severity of illness, medicine, Adverse effect, psoriasi, Adalimumab, Infliximab, 2708, Proportional hazards model, business.industry, tumor necrosis factor-alfa inhibitor, Retrospective cohort study, medicine.disease, Confidence interval, Surgery, ANTI-TNFA, business
Abstract

Background: Some studies have shown that switching patients from one tumor necrosis factor (TNF)-alfa inhibitor to another may be beneficial when they have an inadequate response or an adverse event. Objective: We sought to assess the variables predicting the efficacy of the second TNF-alfa inhibitor in patients discontinuing the first TNF-alfa inhibitor. Methods: Data from all 5423 consecutive patients starting TNF-alfa inhibitor therapy for psoriasis between September 2005 and September 2010 who were included in the Italian Psocare registry were analyzed. Results: In 105 patients who switched to a second TNF-alfa inhibitor who had complete follow-up data, 75% improvement in the Psoriasis Area Severity Index score (PASI 75) was reached by 29% after 16 weeks and by 45.6% after 24 weeks. Patients who switched because of secondary loss of efficacy (loss of initial PASI 75 response) or adverse events/intolerance were more likely to reach PASI 75 than those who switched as a result of primary inefficacy (PASI 75 never achieved) (hazard ratio 2.7, 95% confidence interval 1.3-5.5 vs hazard ratio 2.0, 95% confidence interval 1.0-3.9 and 1, respectively). Limitations: There was a small number of patients with complete follow-up data. Conclusion: PASI 75 response in patients who switched from one antie-TNF-alfa agent to another was significantly reduced in patients who showed primary inefficacy of the first antie-TNF-alfa.

Published
2014

20. Il Centro di Psichiatria Multietnica George Deveraux di Bologna: setting e relazioni di aiuto

Author

TARRICONE, ILARIA, SPIGONARDO, VINCENZO, MANGANARO, DARIO, MERINI, ALBERTO, FERRARI, GIUSEPPE, BERARDI, DOMENICO, Salvatori F., Di Marco S., Malaffo l., Poggi F., Fini C., Morri M., Nolet M., Tonti L., Parmeggiani L., Maisto R., Tarricone I., Salvatori F., Di Marco S., Malaffo l., Poggi F., Spigonardo V., Manganaro D., Fini C., Morri M., Nolet M., Tonti L., Parmeggiani L., Maisto R., Merini A., Ferrari G., and Berardi D.

Published
2006

21. Metabolic abnormalities associated with initiation of systemic treatment for psoriasis: Evidence from the Italian Psocare Registry

Author

Gisondi, P., Cazzaniga, S., Chimenti, S., Giannetti, A., Maccarone, M, Picardo, M., Girolomoni, G., Naldi, L., Griseta, V, Miracapillo, A, Azzini, M, Mocci, L, Michelini, M, Offidani, A, Bernardini, L, Campanati, A, Ricotti, G, Giacchetti, A, Norat, M, Gualco, F, Castelli, A, Cuccia, A, Diana, A, Roncarolo, G, Belli, Ma, Baldassarre, Ma, Santoro, G, Vena, Ga, Lo Console, F, Filotico, R, Mastrandrea, V, Brunetti, B, Musumeci, F, Carrabba, E, Dal Mas, P, Annicchiarico, F, Benvegnù, B, Spaziani, G, Cusano, F, Saletta Iannazzone, S, Galluccio, A, Pezza, M, Marchesi, L, Imberti, G, Reseghetti, A, Barbera, C, Reggiani, M, Lanzoni, A, Patrizi, A, Bardazzi, F, Antonucci, A, De Tommaso, S, Balestri, R, Wallnofer, W, Ingannamorte, F, Calzavara-Pinton, P, Iannazzi, S, Zane, C, Capezzera, R, Bassisi, S, Rossi, Mt, Altamura, V, Vigl, W, Nobile, C, Aste, N, Murgia, S, Mugheddu, C, Scuderi, G, Baglieri, F, Di Dio, C, Cilioni Grilli, E, Mastronardi, C, Agnusdei, Cp, Antrilli, A, Aulisa, L, Raimondo, U, Scotto di Luzio, G, Battarra, Vc, Farro, P, Plaitano, R, Micali, G, Musumeci, Ml, Massimino, D, Li Calzi, M, La Greca, S, Pettinato, M, Sapienza, G, Valenti, G, De Giacomo PF, D'Amico, D, Arcangeli, F, Brunelli, D, Ghetti, E, Tulli, A, Assi, G, Amerio, P, Laria, G, Prestinari, F, Spadafora, S, Coppola, M, Caresana, G, Pezzarossa, E, Domaneschi, E, Felisi, C, Donato, L, Bertero, M, Musso, L, Pa lazzini, S, Bruscino, P, Agozzino, Uc, Ottaviani, M, Simoncini, C, Virgili, A, Osti, F, Fabbri, P, Volpi, W, Caproni, M, Lotti, T, Prignano, F, Buggiani, G, Troiano, M, Fenizi, G, Altobella, A, Amoruso, A, Condello, M, Goffredo, A, Righini, Mg, Alessandrini, F, Satolli, F, Zampetti, M, Bertani, E, Fossati, S, Parodi, A, Burlando, M, Fiorucci, C, Nigro, A, Ghigliotti, G, Massone, L, Moise, Gm, Serrai, M, Cannata, G, Campagnoli, Am, Daly, M, Leporati, C, Peila, R, Filosa, G, Bugatti, L, Nicolini, M, Nazzari, G, Cestari, R, Anastasio, F, Larussa, Fm, Pollice, N, De Francesco, F, Mazzocchetti, G, Peris, K, Fargnoli, Mc, Di Cesare, A, De Angelis, L, Flati, G, Biamonte, As, Quarta, G, Congedo, M, Carcaterra, A, Strippoli, D, Fideli, D, Marsili, F, Celli, M, Ceccarini, M, Bachini, L, D'Oria, M, Schirripa, V, De Filippi, C, Martini, P, Lapucci, E, Mazzatenta, C, Ghilardi, A, Simonacci, M, Bettacchi, A, Gasco, R, Zanca, A, Battistini, S, Dattola, S, Vernaci, R, Postorino, F, Zampieri, Pf, Padovan, C, González Intchaurraga MA, Ladurner, J, Guarneri, B, Cannavò, S, Manfrè, C, Borgia, F, Puglisi Guerra, A, Sedona, P, Cattaneo, A, Carrera, C, Fracchiolla, C, Mozzanica, N, Prezzemolo, L, Menni, S, Lodi, A, Martino, P, Monti, M, Mancini, L, Sacrini, F, Altomare, F, Taglioni, M, Lovati, C, Mercuri, Sr, Schiesari, G, Giannetti, A, Conti, A, Lasagni, C, Greco, M, Ronsini, G, Schianchi, S, Fiorentini, C, Niglietta, S, Maglietta, R, Padalino, C, Crippa, D, Pini, M, Rossi, E, Tosi, D, Armas, M, Ruocco, V, Ayala, F, Balato, N, Gaudiello, F, Cimmino, Gf, Monfrecola, G, Gallo, L, Argenziano, G, Fulgione, E, Berruti, G, Ceparano, I, De Michele, I, Giorgiano, D, Leigheb, G, Deledda, S, Peserico, A, Alaibac, M, Piaserico, S, Schiesari, L, Dan, G, Mattei, I, Oro, E, Aricò, M, Bongiorno, Mr, Angileri, R, Amato, S, Todaro, F, Milioto, M, Bellastro, R, Di Nuzzo, S, De Panfilis, G, Zanni, M, Borroni, G, Cananzi, R, Brazzelli, V, Lisi, P, Stingeni, L, Hansel, K, Pierfelice, V, Donelli, S, Rastelli, D, Gasperini, M, Barachini, P, Cecchi, R, Bartoli, L, Pavesi, M, De Paola, S, Corradin, Mt, Ricciuti, F, Piccirillo, A, Viola, L, Tataranni, M, Mautone, Mg, Lo Scocco, G, Niccoli, Mc, Brunasso Vernetti AM, Gaddoni, G, Resta, F, Casadio, Mc, Arcidiaco, Mc, Luvarà, Mc, Albertini, G, Di Lernia, V, Guareschi, E, Catrani, S, Morri, M, De Simone, C, D'Agostino, M, Agostino, I, Calvieri, S, Cantoresi, F, Richetta, A, Sorgi, P, Carnevale, C, Nicolucci, F, Berardesca, E, Gubinelli, E, Chimenti, S, Talamonti, M, Camplone, G, Cruciani, G, Riccardi, F, Barbati, R, Zumiani, G, Pagani, W, Malagoli, Pg, Pellicano, R, Donadio, D, Di Vito, C, Cottoni, F, Montesu, Ma, Pirodda, C, Addis, G, Marongiu, P, Farris, A, Cacciapuoti, M, Verrini, A, Desirello, G, Gnone, M, Fimiani, M, Pellegrino, M, Castelli, G, Zappalà, L, Sesana, G, Ingordo, V, Vozza, Dg, Di Giuseppe, D, Fasciocco, D, Nespoli, P, Papini, M, Cicoletti, M, Bernengo, Mg, Ortoncelli, M, Bonvicino, A, Capella, G, Doveil, Gc, Forte, M, Peroni, A, Salomone, B, Savoia, P, Pippione, M, Zichichi, L, Frazzitta, M, De Luca, G, Tasin, L, Simonetto, S, Ros, S, Trevisan, G, Patamia, M, Miertusova, S, Patrone, A, Frattasio, A, Piccirillo, F, La Spina, S, Di Gaetano, L, Udine, Marzocchi, V, Motolese, A, Venturi, C, Gai, F, Pasquinucci, S, Bellazzi, Rm, Silvestri, T, Girolomoni, G, Gisondi, P, Veller Fornasa, C, Trevisan, Gp., Gisondi, P, Cazzaniga, S, Chimenti, S, Giannetti, A, Maccarone, M, Picardo, M, Girolomoni, G, Naldi, L, Monfrecola, Giuseppe, Psocare Study, G. r. o. u. p., P., Gisondi, S., Cazzaniga, S., Chimenti, A., Giannetti, M., Maccarone, M., Picardo, G., Girolimoni, L., Naldi, Trevisan, Giusto, Psocare Study Group: [.., M. Reggiani, A. Lanzoni, A. Patrizi, F. Bardazzi, A. Antonucci, S. De Tommaso, R. Balestri, and ]

Subjects
Adult, Male, arterial hypertension, Adolescent, Antineoplastic Agents, Risk Assessment, Severity of Illness Index, Antibodies, Drug Administration Schedule, Cohort Studies, Dose-Response Relationship, Young Adult, Settore MED/35, Age Distribution, Metabolic Diseases, Monoclonal, metabolic disorders, Humans, Psoriasis, Prospective Studies, Registries, Sex Distribution, Antibodies, Monoclonal, Dose-Response Relationship, Drug, Evidence-Based Medicine, Female, Immunosuppressive Agents, Incidence, Italy, Treatment Outcome, 2708, Infectious Diseases, METABOLIC SYNDROME, psoriasis, metabolic abnormalities, Treatment, therapy, Metabolic abnormalitie, metabolic comorbidities, Metabolic abnormalities, Drug
Abstract

OBJECTIVE: To evaluate variations in laboratory parameters and diagnoses of selected clinical conditions up to 16 weeks after starting a new systemic psoriasis treatment for Psocare Registry enrollees. DESIGN: Prospective cohort study. SETTING: Italian public referral centres for psoriasis treatment. PATIENTS: First-time recipients (n = 10,539) of continuous systemic psoriasis treatment for at least 16 weeks. MAIN OUTCOME MEASURE: Mean variations in (weeks 8 and 16) and proportions of patients reaching a clinically meaningful increase in serum levels (week 16) of total and low-density lipoprotein cholesterol, triglycerides, aspartate amino transferase, alanine amino transferase and creatinine, as well as week-16 cumulative incidences of new diagnoses of diabetes mellitus and arterial hypertension. RESULTS: Mean cholesterol and triglyceride levels significantly increased in patients treated with acitretin or cyclosporine. Mean triglyceride levels also increased in efalizumab- and etanercept-treated patients. Mean transaminase values increased in methotrexate-treated patients, and mean aspartate amino transferase levels increased in infliximab-treated patients. The average serum creatinine value increased in cyclosporine-treated patients. Acitretin and cyclosporine were associated with risk of hypercholesterolaemia (odds ratios 1.51 and 1.34) and acitretin with risk of hypertriglyceridaemia (odds ratio 1.43). Methotrexate and infliximab were associated with risk of more than doubling the upper normal aspartate amino transferase (odds ratios 2.06 and 1.87) and alanine amino transferase (odds ratios 2.38 and 1.74) values. The relative risk of developing arterial hypertension and diabetes was increased for patients receiving cyclosporine (odds ratios 3.31 and 2.88). CONCLUSION: Systemic treatments for psoriasis resulted in heterogeneous effects on the parameters analysed.

Published
2013

26. Mean Velocity Predictions in Vegetated Flows.

Author

Morri, M., Soualmia, A., and Belleudy, P.

Subjects
VEGETATION dynamics, FLUID flow, VELOCITY measurements, MATHEMATICAL models
Abstract

Vegetation plays an important role in influencing the hydrodynamic behavior, ecological equilibrium and environmental characteristics of water bodies. Several previous models have been developed, to predict hydraulic conditions in vegetated rivers, but only few are actually used in practice. In This paper six analytic model derived for submerged vegetation are compared and evaluate: Klopstra et al. (1997); Stone and Shen (2002); Van velzen (2003); Baptist et al. (2007); Huthoff et al. (2007) and Yang and Choi (2010). The evaluation of the flow formulas is based on the comparison with experimental data from literature using the criteria of deviation. Most descriptors show a good performance for predicting the mean velocity for rigid vegetation. However, the flow formulas proposed by Klopstra et al. (1997) and Huthoff et al. (2007) show the best fit to experimental data. Only for experiments with law density, these models indicate an underestimation. Velocity predicted for flexible vegetation by the six models is less accurate than the prediction in the case of rigid vegetation. [ABSTRACT FROM AUTHOR]

Published
2016

31. Estimation of Root-zone Salinity Using SaltMod in the Irrigated Area of Kalaât El Andalous (Tunisia).

Author

Ferjani, N., Morri, M., and Daghari, I.

Subjects
*SALINITY, *PLANT roots, *IRRIGATION, *ESTIMATION theory, *SALINIZATION
Abstract

In Tunisia, Kalâat El Andalous irrigated district is one of the most affected areas by salinization. The objective of this study was to predict the root zone salinity (over 10 years) in this area using the SaltMod simulation model for subsurface drainage system. SaltMod is based on water balance, salt balance model, and seasonal agronomic aspects. In the pilot area, irrigated vegetables crops such as tomato (Lycopersicum esculentum), melon (Cucumis mela) and squash (Cucurbuta maxima) occupy the field during summer and rainfed wheat during winter. The model predicted more or less similar values of electrical conductivity in the root zone. Highest value of electrical conductivity reached during the irrigation season was 7.7 dS m-1. Following the fall rains, there was a decrease of the soil salinity when the average minimum value of electrical conductivity was 3.1 dS m-1. The simulation also showed that decreasing the depth of the drain did not change significantly the root zone salinity. The depth of the drain could be reduced to 1.6 m without any damage to crops. There was a slight reduction in drainage flow when the depth of the drain changed from 1.8 m to 1.2 m. Decrease of the drain depth decreased water table level. There was no variation in root zone salinities due to change in drain spacing. The predicted drainage flows were related to the occurrence of irrigation and rainfall. In this study, calibration of SaltMod for water-salt balance parameters proved the validity of the model for the local conditions. [ABSTRACT FROM AUTHOR]

Published
2013

32. QUANTIFICATION DE LA DOSE DE LESSIVAGE ET PERFORMANCE DU RESEAU DE DRAINAGE DANS LE PERIMETRE IRRIGUE DE KALAAT EL ANDALOUS (TUNISIE).

Author

MORRI, M. and DAGHARI, H.

Abstract

Copyright of Larhyss Journal is the property of Biskra University, Research Laboratory in Subterranean & Surface Hydraulics and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Published
2013

33. A measurement of the forward-backward charge asymmetry in hadronic decays of the Z0

Author

Acton, P.D., primary, Alexander, G., additional, Allison, J., additional, Allport, P.P., additional, Anderson, K.J., additional, Arcelli, S., additional, Astbury, A., additional, Axen, D., additional, Azuelos, G., additional, Bahan, G.A., additional, Baines, J.T.M., additional, Ball, A.H., additional, Banks, J., additional, Barlow, R.J., additional, Barnett, S., additional, Batley, J.R., additional, Beaudoin, G., additional, Beck, A., additional, Becker, J., additional, Behnke, T., additional, Bell, K.W., additional, Bella, G., additional, Berlich, P., additional, Bethke, S., additional, Biebel, O., additional, Binder, U., additional, Bloodworth, I.J., additional, Bock, P., additional, Boden, B., additional, Bosch, H.M., additional, Bougerolle, S., additional, Breuker, H., additional, Brown, R.M., additional, Buijs, A., additional, Burckhart, H.J., additional, Capiluppi, P., additional, Carnegie, R.K., additional, Carter, A.A., additional, Carter, J.R., additional, Chang, C.Y., additional, Charlton, D.G., additional, Clarke, P.E.L., additional, Cohen, I., additional, Clayton, J.C., additional, Collins, W.J., additional, Conboy, J.E., additional, Cooper, M., additional, Coupland, M., additional, Cuffiani, M., additional, Dado, S., additional, Dallavalle, G.M., additional, De Jong, S., additional, del Pozo, L.A., additional, Deng, H., additional, Dieckmann, A., additional, Dittmar, M., additional, Dixit, M.S., additional, do Couto e Silva, E., additional, Duboscq, J.E., additional, Duchovni, E., additional, Duckeck, G., additional, Duerdoth, I.P., additional, Dumas, D.J.P., additional, Elcombe, P.A., additional, Estabrooks, P.G., additional, Etzion, E., additional, Evans, H.G., additional, Fabbri, F., additional, Fincke-Keeler, M., additional, Fischer, H.M., additional, Fong, D.G., additional, Foucher, M., additional, Gaidot, A., additional, Ganel, O., additional, Gary, J.W., additional, Gascon, J., additional, McGowan, R.F., additional, Geddes, N.I., additional, Geich-Gimbel, C., additional, Gensler, S.W., additional, Gentit, F.X., additional, Giacomelli, G., additional, Gibson, V., additional, Gibson, W.R., additional, Gillies, J.D., additional, Goldberg, J., additional, Goodrick, M.J., additional, Gorn, W., additional, Grandi, C., additional, Grant, F.C., additional, Hagemann, J., additional, Hanson, G.G., additional, Hansroul, M., additional, Hargrove, C.K., additional, Harrison, P.F., additional, Hart, J., additional, Hattersley, P.M., additional, Hauschild, M., additional, Hawkes, C.M., additional, Heflin, E., additional, Hemingway, R.J., additional, Heuer, R.D., additional, Hill, J.C., additional, Hillier, S.J., additional, Hilse, T., additional, Hinshaw, D.A., additional, Hobbs, J.D., additional, Hobson, P.R., additional, Hochman, D., additional, Homer, R.J., additional, Honma, A.K., additional, Howarth, C.P., additional, Hughes-Jones, R.E., additional, Humbert, R., additional, Igo-Kemenes, P., additional, Ihssen, H., additional, Imrie, D.C., additional, Janissen, A.C., additional, Jawahery, A., additional, Jeffreys, P.W., additional, Jeremie, H., additional, Jimack, M., additional, Jobes, M., additional, Jones, R.W.L., additional, Jovanovic, P., additional, Jui, C., additional, Karlen, D., additional, Kawagoe, K., additional, Kawamoto, T., additional, Keeler, R.K., additional, Kellogg, R.G., additional, Kennedy, B.W., additional, Kluth, S., additional, Kobayashi, T., additional, Kokott, T.P., additional, Komamiya, S., additional, Köpke, L., additional, Kral, J.F., additional, Kowalewski, R., additional, von Krogh, J., additional, Kroll, J., additional, Kuwano, M., additional, Kyberd, P., additional, Lafferty, G.D., additional, Lamarche, F., additional, Layter, J.G., additional, Le Du, P., additional, Leblanc, P., additional, Lee, A.M., additional, Lehto, M.H., additional, Lellouch, D., additional, Lennert, P., additional, Leroy, C., additional, Letts, J., additional, Levegrün, S., additional, Levinson, L., additional, Lloyd, S.L., additional, Loebinger, F.K., additional, Lorah, J.M., additional, Lorazo, B., additional, Losty, M.J., additional, Lou, X.C., additional, Ludwig, J., additional, Mannelli, M., additional, Marcellini, S., additional, Maringer, G., additional, Markus, C., additional, Martin, A.J., additional, Martin, J.P., additional, Mashimo, T., additional, Mättig, P., additional, Maur, U., additional, McKenna, J., additional, McMahon, T.J., additional, McNutt, J.R., additional, Meijers, F., additional, Menszner, D., additional, Merritt, F.S., additional, Mes, H., additional, Michelini, A., additional, Middleton, R.P., additional, Mikenberg, G., additional, Mildenberger, J., additional, Miller, D.J., additional, Mir, R., additional, Mohr, W., additional, Moisan, C., additional, Montanari, A., additional, Mori, T., additional, Morri, M., additional, Mouthuy, T., additional, Nellen, B., additional, Nguyen, H.H., additional, Nozaki, M., additional, O'Neale, S.W., additional, Oakham, F.G., additional, Odorici, F., additional, Ogren, H.O., additional, Oram, C.J., additional, Oreglia, M.J., additional, Orito, S., additional, Pansart, J.P., additional, Panzer-Steindel, B., additional, Paschievici, P., additional, Patrick, G.N., additional, Paz-Jaoshvili, N., additional, Pfister, P., additional, Pilcher, J.E., additional, Pitman, D., additional, Plane, D.E., additional, Poffenberger, P., additional, Poli, B., additional, Pouladdej, A., additional, Prebys, E., additional, Pritchard, T.W., additional, Przysiezniak, H., additional, Quast, G., additional, Redmond, M.W., additional, Rees, D.L., additional, Richards, G.E., additional, Robinson, D., additional, Rollnik, A., additional, Roney, J.M., additional, Ros, E., additional, Rossberg, S., additional, Rossi, A.M., additional, Rosvick, M., additional, Routenburg, P., additional, Runge, K., additional, Runolfsson, O., additional, Rust, D.R., additional, Sasaki, M., additional, Sbarra, C., additional, Schaile, A.D., additional, Schaile, O., additional, Schappert, W., additional, Scharff-Hansen, P., additional, Schenk, P., additional, von der Schmitt, H., additional, Schreiber, S., additional, Schwick, C., additional, Schwiening, J., additional, Scott, W.G., additional, Settles, M., additional, Shears, T.G., additional, Shen, B.C., additional, Shepherd-Themistocleous, C.H., additional, Sherwood, P., additional, Shypit, R., additional, Simon, A., additional, Singh, P., additional, Siroli, G.P., additional, Skuja, A., additional, Smith, A.M., additional, Smith, T.J., additional, Snow, G.A., additional, Sobie, R., additional, Springer, R.W., additional, Sproston, M., additional, Stephens, K., additional, Steuerer, J., additional, Ströhmer, R., additional, Strom, D., additional, Takeshita, T., additional, Taras, P., additional, Tarem, S., additional, Tecchio, M., additional, Teixeira-Dias, P., additional, Tesch, N., additional, Thackray, N.J., additional, Transtromer, G., additional, Tresilian, N.J., additional, Tsukamoto, T., additional, Turner, M.F., additional, Tysarczyk-Niemeyer, G., additional, Van den plas, D., additional, Van Kooten, R., additional, VanDalen, G.J., additional, Vasseur, G., additional, Virtue, C.J., additional, Wagner, A., additional, Wagner, D.L., additional, Wahl, C., additional, Walker, J.P., additional, Ward, C.P., additional, Ward, D.R., additional, Watkins, P.M., additional, Watson, A.T., additional, Watson, N.K., additional, Weber, M., additional, Weber, P., additional, Weisz, S., additional, Wells, P.S., additional, Wermes, N., additional, Whalley, M.A., additional, Wilson, G.W., additional, Wilson, J.A., additional, Winterer, V.-H., additional, Wlodek, T., additional, Wotton, S., additional, Wyatt, T.R., additional, Yaari, R., additional, Yeaman, A., additional, Yekutieli, G., additional, Yurko, M., additional, Zeuner, W., additional, and Zorn, G.T., additional

Published
1992
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34. Changing Morbidity of Cutaneous Diseases in Patients with HIV After the Introduction of Highly Active Antiretroviral Therapy Including a Protease Inhibitor.

Author

Calista, D., Morri, M., Stagno, A., and Boschini, A.

Subjects
*HIV infections, *THERAPEUTICS, *THERAPEUTIC use of protease inhibitors, *REVERSE transcriptase, *DRUG side effects, *CHEMICAL inhibitors
Abstract

Background: Highly active antiretroviral therapy (HAART) is a combination of an HIV protease inhibitor (PI), one or two reverse transcriptase inhibitors (RTIs) and/or non-nuclease reverse transcriptase inhibitors (NNRTIs). This combination therapy is able to reduce peripheral HIV viral load, elevate CD4+ cell counts and improve the clinical outcome. Aim: To evaluate the impact of HAART therapy, including one PI, on the prevalence of skin diseases in patients with HIV/AIDS. Patients and methods: The study was performed by collecting data about HIV populations followed at the ‘M. Bufalini’ Infectious Diseases Unit and San Patrignano Medical Centre, Italy. The medical records regarding the dermatological diseases of such people were retrospectively examined in 12-month periods before (1996) and after (1999) the introduction of HAART. Results: The two groups of patients were matched for age, gender and stage of HIV disease. During the first part of the study, 328 of the 456 patients (72%) sought medical advice 689 times for dermatoses. In the second period, 196 of the 502 patients (39%) made a total of 255 visits. There was a considerable decrease in the number of dermatological visits (-63%) and patients with dermatological problems (-40%). In the group that did not receive HAART, 66% of the patients had cutaneous infections, 25% had inflammatory cutaneous disorders, 8% adverse cutaneous drug reactions and 1% cutaneous neoplasms. In the group of patients treated with HAART, cutaneous infections were observed in 53% of patients, while 21% of patients had inflammatory dermatoses, 20% of patients showed adverse cutaneous drug reactions, and 1% had skin cancers. The remaining 5% asked to see a dermatologist for cosmetic reasons. Conclusions: The group of patients who received combination regimens including PIs had significantly lower cutaneous morbidity than those treated with nucleoside analogs alone. This tendency included both opportunistic infections and inflammatory cutaneous diseases. Adverse cutaneous drug reactions related to multidrug combination therapy were significantly higher in the group receiving HAART. [ABSTRACT FROM AUTHOR]

Published
2002
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36. A determination ofαs( <img src="/fulltext-image.asp?format=htmlnonpaginated&src=T6G24400428V617M_html\10052_2005_Article_BF01555834_TeX2GIFIE1.gif" border="0" alt=" $$M_{Z^0 } $$ " />) at LEP using resummed QCD calculations

Author

Acton, P. D., Alexander, G., Allison, J., Allport, P. P., Anderson, K. J., Arcelli, S., Astbury, A., Axen, D., Azuelos, G., Bahan, G. A., Baines, J. T. M., Ball, A. H., Banks, J., Barlow, R. J., Barnett, S., Batley, J. R., Beaudoin, G., Beck, A., Beck, G. A., Becker, J., Behnke, T., Bell, K. W., Bella, G., Bentkowski, P., Berlich, P., Bethke, S., Biebel, O., Binder, U., Bloodworth, I. J., Bock, P., Boden, B., Bosch, H. M., Breuker, H., Bright-Thomas, P., Brown, R. M., Buijs, A., Burckhart, H. J., Burgard, C., Capiluppi, P., Carnegie, R. K., Carter, A. A., Carter, J. R., Chang, C. Y., Charlton, D. G., Chu, S. L., Clarke, P. E. L., Cohen, I., Clayton, J. C., Collins, W. J., Conboy, J. E., Cooper, M., Coupland, M., Cuffiani, M., Dado, S., Dallavalle, G. M., De Jong, S., del Pozo, L. A., Deng, H., Dieckmann, A., Dittmar, M., Dixit, M. S., do Couto e Silva, E., Duboscq, J. E., Duchovni, E., Duckeck, G., Duerdoth, I. P., Dumas, D. J. P., Elcombe, P. A., Estabrooks, P. G., Etzion, E., Evans, H. G., Fabbri, F., Fierro, M., Fincke-Keeler, M., Fischer, H. M., Fong, D. G., Foucher, M., Gaidot, A., Ganel, O., Gary, J. W., Gascon, J., McGowan, R. F., Geddes, N. I., Geich-Gimbel, C., Gensler, S. W., Gentit, F. X., Giacomelli, G., Giacomelli, R., Gibson, V., Gibson, W. R., Gillies, J. D., Goldberg, J., Goodrick, M. J., Gorn, W., Grandi, C., Grant, F. C., Hagemann, J., Hanson, G. G., Hansroul, M., Hargrove, C. K., Harrison, P. F., Hart, J., Hattersley, P. M., Hauschild, M., Hawkes, C. M., Heflin, E., Hemingway, R. J., Heuer, R. D., Hill, J. C., Hillier, S. J., Hilse, T., Hinshaw, D. A., Hobbs, J. D., Hobson, P. R., Hochman, D., Homer, R. J., Honma, A. K., Hughes-Jones, R. E., Humbert, R., Igo-Kemenes, P., Ihssen, H., Imrie, D. C., Janissen, A. C., Jawahery, A., Jeffreys, P. W., Jeremie, H., Jimack, M., Jobes, M., Jones, R. W. L., Jovanovic, P., Jui, C., Karlen, D., Kawagoe, K., Kawamoto, T., Keeler, R. K., Kellogg, R. G., Kennedy, B. W., Kluth, S., Kobayashi, T., Koetke, D. S., Kokott, T. P., Komamiya, S., Köpke, L., Kral, J. F., Kowalewski, R., von Krogh, J., Kroll, J., Kuwano, M., Kyberd, P., Lafferty, G. D., Lahmann, R., Lamarche, F., Layter, J. G., Leblanc, P., Lee, A. M., Lehto, M. H., Lellouch, D., Leroy, C., Letts, J., Levegrün, S., Levinson, L., Lloyd, S. L., Loebinger, F. K., Lorah, J. M., Lorazo, B., Losty, M. J., Lou, X. C., Ludwig, J., Manelli, M., Marcellini, S., Maringer, G., Markus, C., Martin, A. J., Martin, J. P., Mashimo, T., Mättig, P., Maur, U., McKenna, J., McMahon, T. J., McNutt, J. R., Meijers, F., Menszner, D., Merritt, F. S., Mes, H., Michelini, A., Middleton, R. P., Mikenberg, G., Mildenberger, J., Miller, D. J., Mir, R., Mohr, W., Moisan, C., Montanari, A., Mori, T., Morri, M., Mouthuy, T., Nellen, B., Nguyen, H. H., Nozaki, M., O'Neale, S. W., Oakham, F. G., Odorici, F., Ogren, H. O., Oram, C. J., Oreglia, M. J., Orito, S., Pansart, J. P., Panzer-Steindel, B., Paschievici, P., Patrick, G. N., Paz-Jaoshvili, N., Pfister, P., Pilcher, J. E., Pinfold, J., Pitman, D., Plane, D. E., Poffenberger, P., Poli, B., Pouladdej, A., Pritchard, T. W., Przysierzniak, H., Quast, G., Redmond, M. W., Rees, D. L., Richards, G. E., Robinson, D., Rollnik, A., Roney, J. M., Ros, E., Rossberg, S., Rossi, A. M., Rosvick, M., Routenburg, P., Runge, K., Runolfsson, O., Rust, D. R., Sasaki, M., Sbarra, C., Schaile, A. D., Schaile, O., Schappert, W., Scharff-Hansen, P., Schenk, P., Schmitt, B., von der Schmitt, H., Schreiber, S., Schwick, C., Schwiening, J., Scott, W. G., Settles, M., Shears, T. G., Shen, B. C., Shepherd-Themistocleous, C. H., Sherwood, P., Shypit, R., Simon, A., Singh, P., Siroli, G. P., Skuja, A., Smith, A. M., Smith, T. J., Snow, G. A., Sobie, R., Springer, R. W., Sproston, M., Stephens, K., Steuerer, J., Ströhmer, R., Strom, D., Takeshita, T., Taras, P., Tarem, S., Tecchio, M., Teixeira-Dias, P., Tesch, N., Thackray, N. J., Thomson, M. A., Torrente-Lujan, E., Transtromer, G., Tresilian, N. J., Tsukamoto, T., Turner, M. F., Tysarczyk-Niemeyer, G., Van den plas, D., Van Kooten, R., Van Dalen, G. J., Vasseur, G., Virtue, C. J., Wagner, A., Wagner, D. L., Wahl, C., Walker, J. P., Ward, C. P., Ward, D. R., Watkins, P. M., Watson, A. T., Watson, N. K., Weber, M., Weber, P., Wells, P. S., Wermes, N., Whalley, M. A., Wilson, G. W., Wilson, J. A., Winterer, V. -H., Wlodek, T., Wotton, S., Wyatt, T. R., Yaari, R., Yeaman, A., Yekutieli, G., Yurko, M., Zeuner, W., and Zorn, G. T.

Abstract

The strong coupling constant, αs, has been determined in hadronic decays of theZ0 resonance, using measurements of seven observables relating to global event shapes, energy correlations and jet rates. The data have been compared with resummed QCD calculations, which are combined with theO(s2) theory. The seven measurements agree to about 10% and the final results, based on a weighted average, is: $$\alpha _s (M_{Z^0 } ) = 0.120 \pm 0.006,$$ where the error includes both experimental and theoretical uncertainties. This value corresponds to renormalization scale " and the error includes the uncertainty in this choice of scale. The present measurement complements previous determinations using theO(s2) QCD matrix elements alone, and yields a compatible result, with comparable errors.

Published
1993
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38. SARS-CoV-2 Infection in San Patrignano, the Largest European Drug Rehabilitation Community

Author

Isabella Sala, Carlotta Micaela Jarach, Vincenzo Bagnardi, Maria Sofia Cattaruzza, Michela Morri, Paolo Ottogalli, Vincenzo Zagà, Silvano Gallus, Antonio Boschini, Sala, I, Jarach, C, Bagnardi, V, Cattaruzza, M, Morri, M, Ottogalli, P, Zaga, V, Gallus, S, and Boschini, A

Subjects
covid-19, italy, sars-cov-2, hospitalization, mortality, Italy, SARS-CoV-2, Health, Toxicology and Mutagenesis, Public Health, Environmental and Occupational Health, COVID-19
Abstract

BACKGROUND: Studies on SARS-CoV-2 conducted in confined settings for prolonged times allow researchers to assess how the coronavirus spreads. San Patrignano (SP), Italy, is the largest European drug rehabilitation facility.METHODS: Between 15 October and 31 December 2020, all SP residents were tested for SARS-CoV-2. We analyzed the relationships between individual characteristics and being SARS-CoV-2-positive. Three selected predictive models were used to calculate the number of expected hospitalizations. For each model, we summed the estimated individual risks to obtain the expected number of hospitalizations in our sample, and we tested whether the observed and expected numbers differed.RESULTS: Of 807 residents, 529 (65.6%) were SARS-CoV-2-positive. Of these 323 (61.1%) were symptomatic. A strong relationship was found between being positive and living connections ( p-value < 0.001). No statistically significant relationship was found with age, sex, smoking history, or comorbidities. Although 9 to 17 hospitalizations were expected, no hospitalizations were observed ( p-value < 0.001). No one died of COVID-19. CONCLUSIONS: The peculiar characteristics of SP residents or the SP environment might at least partially explain the null hospitalization rates. Despite the extreme uniqueness of our population and despite the protected environment and all precautions that were taken, the fact that the virus was able to circulate and infect a large portion of the population highlights the fundamental role of social interactions in the spread of the disease.

Published
2023

39. Is kinesiophobia a predictor of early functional performance after total hip replacement? A prospective prognostic cohort study

Author

A. Ruggiero, A Culcasi, Mattia Morri, C Govoni, E. Venturini, Riccardo Ruisi, Natalia Franchini, Maria Grazia Benedetti, Morri M., Venturini E., Franchini N., Ruisi R., Culcasi A., Ruggiero A., Govoni C., and Benedetti M.G.

Subjects
medicine.medical_specialty, lcsh:Diseases of the musculoskeletal system, WOMAC, Sports medicine, Arthroplasty, Replacement, Hip, medicine.medical_treatment, Population, Osteoarthritis, Hip, Hip replacement (animal), Arthroplasty, Cohort Studies, 03 medical and health sciences, 0302 clinical medicine, Rheumatology, Osteoarthritis, medicine, Humans, Psychology, Orthopedics and Sports Medicine, Prospective Studies, 030212 general & internal medicine, Functional ability, education, Ontario, education.field_of_study, business.industry, Recovery of function, Osteoarthritis, Knee, Physical Functional Performance, Prognosis, Treatment Outcome, Physical therapy, Osteoarthriti, Female, lcsh:RC925-935, business, Body mass index, 030217 neurology & neurosurgery, Research Article, Cohort study
Abstract

Background Considerable attention has been paid to the role of kinesiophobia with respect to knee prosthesis but it has not yet been studied as a prognostic factor of short-term functional performance following total hip replacement. The main purpose of the present study is to examine the possible predictors of early functional performance of patients undergoing total primary hip arthroplasty, including demographics as age, sex and body mass index, preoperative functional ability, type of anaesthesia, level of haemoglobin, pain and level of kinesiophobia before surgery. Secondly, we want to describe the main characteristics of the population with the highest levels of kinesiophobia. Methods A prospective, prognostic cohort study was carried out. Patients undergoing primary hip replacement were recruited consecutively. The main outcome is the early functional performance achieved by patients after surgery and measured using the Iowa Level of Assistance (ILOA) scale on the fifth postoperative day. Preoperative kinesiophobia was measured by the Tampa Scale and the preoperative functional ability by the Western Ontario and McMaster Osteoarthritis Index (WOMAC). The multivariate analysis was performed by the General Linear Model. The analysis of the population with high levels of kinesiophobia was conducted by identifying a cut-off of 40 compared to the Tampa Scale. Results Statistical analysis was performed on 269 patients. The average ILOA score recorded was 19.5 (DS 8.3). The levels of kinesiophobia, showed an average score of 35.1 (7.8) and it was not associated with early functional performance. The independent predictive factors include age, sex and body mass index. Kinesiophobia high levels were recorded in 30% of the population and this population had a higher level of pre-operative WOMAC score. Conclusions Early functional performance after hip replacement surgery was not correlated with the level of kinesiophobia. Three significant factors that describe a population most at risk of not achieving optimal functional performance are increased age, being female and increase in body mass index. In the preoperative phase, high levels of kinesiophobia were associated with more impaired preoperative functional ability. Trial registration Current Controlled Trials NCT02786121, May 2016. Retrospectively registered.

Published
2020

40. Assessment of Ultra-Short Heart Variability Indices Derived by Smartphone Accelerometers for Stress Detection

Author

Andrea Faini, Alba Martin-Yebra, Federica Landreani, Enrico G. Caiani, Gianfranco Parati, Mattia Morri, Landreani, F, Faini, A, Martin-Yebra, A, Morri, M, Parati, G, and Caiani, E

Subjects
Male, Supine position, 030204 cardiovascular system & hematology, Accelerometer, lcsh:Chemical technology, smartphone, Psychological Distress, 01 natural sciences, Biochemistry, Standard deviation, Accelerometers, Ballistocardiography, Seismocardiography, Smartphone, Stress evaluation, Ultra-short heart rate variability, Analytical Chemistry, Electrocardiography, 0302 clinical medicine, Heart Rate, Accelerometry, Heart rate variability, lcsh:TP1-1185, ultra-short heart rate variability, Instrumentation, medicine.diagnostic_test, Atomic and Molecular Physics, and Optics, Cardiology, Breathing, Female, psychological phenomena and processes, Human, Adult, medicine.medical_specialty, accelerometers, stress evaluation, Beat (acoustics), behavioral disciplines and activities, Article, 03 medical and health sciences, seismocardiography, Internal medicine, Heart rate, smartphone accelerometers, medicine, Humans, Electrical and Electronic Engineering, Psychological Distre, business.industry, 010401 analytical chemistry, biomedical_chemical_engineering, 0104 chemical sciences, business, Beat (music), human activities
Abstract

Body acceleration due to heartbeat-induced reaction forces can be measured as mobile phone accelerometer (m-ACC) signals. Our aim was to test the feasibility of using m-ACC to detect changes induced by stress by ultra-short heart rate variability (USV) indices (standard deviation of normal-to-normal interval&mdash, SDNN and root mean square of successive differences&mdash, RMSSD). Sixteen healthy volunteers were recruited, m-ACC was recorded while in supine position, during spontaneous breathing at rest conditions (REST) and during one minute of mental stress (MS) induced by arithmetic serial subtraction task, simultaneous with conventional electrocardiogram (ECG). Beat occurrences were extracted from both ECG and m-ACC and used to compute USV indices using 60, 30 and 10s durations, both for REST and MS. A feasibility of 93.8% in the beat-to-beat m-ACC heart rate series extraction was reached. In both ECG and m-ACC series, compared to REST, in MS the mean beat duration was reduced by 15% and RMSSD decreased by 38%. These results show that short term recordings (up to 10 s) of cardiac activity using smartphone&rsquo, s accelerometers are able to capture the decrease in parasympathetic tone, in agreement with the induced stimulus.

Published
2019

41. Effect of Game Based Balance Exercises on Rehabilitation After Knee Surgery: A Controlled Observational Study

Author

Mattia Morri, Davide Maria Donati, Maria Grazia Benedetti, Daniela Vigna, Debora Raffa, Morri M., Vigna D., Raffa D., Donati D., and Benedetti M.G.

Subjects
Adult, Male, medicine.medical_specialty, 020205 medical informatics, Adolescent, medicine.medical_treatment, Medicine (miscellaneous), Health Informatics, Bone Neoplasms, 02 engineering and technology, Bone Neoplasm, Walking speed, Disability Evaluation, Young Adult, Health Information Management, Games, Recreational, Retrospective Studie, 0202 electrical engineering, electronic engineering, information engineering, Postural Balance, Medicine, Humans, Range of Motion, Articular, Arthroplasty, Replacement, Knee, Balance (ability), Retrospective Studies, Serious game, Rehabilitation, Proprioception, business.industry, Recovery of Function, Balance exercises, medicine.disease, Primary tumor, Exercise Therapy, Preferred walking speed, Postural balance, Physical therapy, Observational study, Female, business, Information Systems, Human
Abstract

Does a rehabilitation protocol based on balance exercises using Serious Game improve walk performance in patients undergoing knee resection and reconstruction for bone primary tumor?. 30 patients undergoing modular prosthetic replacement, following a primary bone tumor, were consecutively enrolled. During each hospitalization a physiotherapy treatment was activated, included 25min training phase aimed postural and proprioceptive control. In order to better evaluate the walking speed at one-year post surgery in the study group, data were compared with a group of 22 patients treated in a previous period, called the control group, collected retrospectively. The control group differed only for the type of physiotherapy treatment offered. No statistically significant differences emerged from the two groups, regarding baseline characteristics. Walking speed in the study group was improved compared to the control group with a median difference of 0.22m/s (p = 0.022). A difference was also measured in the speed of centre mass, with a median reduction of 4.5mm/s (p = 0.005) in the study group, showing an improvement in postural control in stand-up position. Exercises aimed at recovering balance and Serious Game should be proposed in order to improve motor performance and postural control in the medium and long term.

Published
2019

42. Prevalence and Gender Differences in Late-Life Depression: A Population-Based Study

Author

Diana De Ronchi, Anna Rita Atti, Marco Menchetti, E. Dalmonte, Barbara Ferrari, M. Morri, C. Forlani, Forlani C, Morri M, Ferrari B, Dalmonte E, Menchetti M, De Ronchi D, and Atti AR

Subjects
Male, Gerontology, Population ageing, LATE-LIFE, Population, Prevalence, Logistic regression, Sex Factors, Risk Factors, Activities of Daily Living, Humans, Age of Onset, education, Depression (differential diagnoses), Aged, Aged, 80 and over, ELDERLY, Depressive Disorder, Depressive Disorder, Major, education.field_of_study, Marital Status, Depression, Social Support, Odds ratio, Late life depression, GENDER DIFFERENCES, Social Participation, Confidence interval, Psychiatry and Mental health, Cross-Sectional Studies, Logistic Models, Italy, Multivariate Analysis, Female, Geriatrics and Gerontology, Psychology
Abstract

Objective The worldwide phenomenon of an aging population combined with the increasing prevalence of depression in late life are issues that need to be addressed. This study aims to estimate the frequency of depression and subthreshold depression occurring in a sample of cognitively well-functioning, community-dwelling, older Italian adults and to investigate sociodemographic and clinical correlates of depression, exploring gender differences. Methods We used a cross-sectional analyses of survivors in a population-based study (the Faenza Project) that included 359 subjects aged 74 years and older (49.3% women). A modified version of Cambridge Examination for Mental Disorders of Elderly Persons-Revised was administered to all participants. Prevalence rates of depression and 95% confidence intervals (CIs) were estimated according to International Classification of Diseases, Tenth Revision criteria. Statistical analyses were implemented to describe sociodemographic and clinical features associated with depression. Odds ratios were estimated by multivariate logistic regression, and the dependant variable was any type of depression. Results Overall prevalence of depression was 25.1% (95% CI: 20.6–29.6), with no evidence of gender difference. Prevalence of mild, moderate, and severe depression was 16.4% (95% CI: 12.6–20.2), 7.5% (95% CI: 4.8–10.2), and 1.1 (95% CI: –0.4–2.6), respectively. A rate of 5.6% of the population complained of subthreshold depressive symptoms. After age 81, depression occurrence decreased as age increased. The association between depression and functional measures, such as primary activity, mobility, and disability in performing household chores, were stronger in men than in women. Similarly, severely disabling conditions like stroke were more strongly associated with depression in men than in women. Conclusion Our data suggest a disparity between men and women regarding the impact of depression on everyday life. Specific gender differences need to be taken into account for the evaluation of the depression-related burden in late life.

Published
2014

43. Anxiety symptoms in 74+ community-dwelling elderly: associations with physical morbidity, depression and alcohol consumption

Author

Tobias Attili, V. Bernabei, Diana De Ronchi, Martino Belvederi Murri, M. Forlani, F. Moretti, M. Morri, Anna Biondini, Anna Rita Atti, Forlani M, Morri M, Belvederi Murri M, Bernabei V, Moretti F, Attili T, Biondini A, De Ronchi D, and Atti AR.

Subjects
Male, Phisical morbidity, Cross-sectional study, Epidemiology, lcsh:Medicine, Anxiety, Axiety, Elderly, Odds Ratio, Prevalence, lcsh:Science, Depression (differential diagnoses), Geriatrics, Psychiatry, Aged, 80 and over, education.field_of_study, Multidisciplinary, Depression, Epidemiology of Aging, Anxiety Disorders, Mental Health, Italy, Medicine, Regression Analysis, Female, medicine.symptom, Research Article, medicine.medical_specialty, Alcohol Drinking, Clinical Research Design, Population, NO, Sex Factors, medicine, Humans, education, Biology, Lifecourse Epidemiology, Aged, Population Biology, business.industry, Mood Disorders, lcsh:R, Odds ratio, Confidence interval, Cross-Sectional Studies, lcsh:Q, business, Geriatric psychiatry
Abstract

Objective Anxiety among community-dwelling older adults has not been studied sufficiently. The aims of this cross-sectional population-based study were to estimate the point prevalence of clinically relevant anxiety symptoms and to describe their socio-demographic and clinical features, with particular focus on the association with somatic illnesses. Methods Three-hundred-sixty-six non-demented older adults (mean age 83.7±6.2, range 74–99 years) from the Faenza Project (Northern Italy) were assessed using the Cambridge Mental Disorders of the Elderly Examination-Revised (CAMDEX-R) and the Geriatric Anxiety Inventory short form (GAI-sf). Multi-adjusted regression analyses were used to estimate Odds Ratio (OR) and 95% Confidence Intervals (95% CI). Results Clinically relevant anxiety symptoms occurred in one out of five participants (point prevalence 21.0%) and were significantly associated with depression (OR 5.6 per rank; 95% CI: 3.1–10.1), physical morbidity (OR 3.5 per illness; 95% CI: 1.0–11.9) and female gender (OR 2.8; 95% CI: 1.4–5.5). Further, there were significant associations with a consumption of alcohol exceeding 1 alcoholic unit/day. Conclusions Anxiety symptoms are very common in older subjects, especially when medically ill. Depression and alcohol consumption often co-occur with late-life anxiety symptoms, thus requiring special attention in daily clinical practice.

Published
2014

44. Layer-dependent Debye temperature and thermal expansion of Ru(0001) by means of high-energy resolution core-level photoelectron spectroscopy

Author

Lorenzo Galli, Alessandro Baraldi, Mirko Panighel, Silvano Lizzit, Maria Ricci, Elisa Miniussi, Maurizio Morri, Eugenio Ferrari, Paolo Lacovig, Ferrari, Eugenio, Galli, L., Miniussi, E., Morri, M., Panighel, Mirco, Ricci, M., Lacovig, P., Lizzit, S., and Baraldi, Alessandro

Subjects
Materials science, Phonon, Binding energy, Anharmonicity, Atmospheric temperature range, Condensed Matter Physics, Debye temperature, ruthenium, core level spectroscopy, thermal expansion, Electron spectroscopy, Spectral line, Electronic, Optical and Magnetic Materials, symbols.namesake, symbols, Atomic physics, Spectroscopy, Debye model
Abstract

The layer-dependent Debye temperature of Ru(0001) is determined by means of high-energy resolution core-level photoelectron spectroscopy measurements. The possibility to disentangle three different components in the Ru 3d{sub 5/2} spectrum of Ru(0001), originating from bulk, first-, and second-layer atoms, allowed us to follow the temperature evolution of their photoemission line shapes and binding energies. Temperature effects were detected, namely, a lattice thermal expansion and a layer-dependent phonon broadening, which was interpreted within the framework of the Hedin-Rosengren formalism based on the Debye theory. The resulting Debye temperature of the top-layer atoms is 295{+-}10 K, lower than that of the bulk (T=668{+-}5 K) and second-layer (T=445{+-}10 K) atoms. While these results are in agreement with the expected phonon softening at the surface, we show that a purely harmonic description of the motion of the surface atoms is not valid, since anharmonic effects contribute significantly to the position and line shape of the different core-level components.

Published
2010

45. Old but gold: Is the Judet procedure still a viable option for posttraumatic knee stiffness in 2024? A comprehensive systematic review and meta-analysis.

Author

Rinaldi VG, Sassoli I, Fogacci A, Favero A, Lullini G, Mosca M, Morri M, Zaffagnini S, and Marcheggiani Muccioli GM

Abstract

Background: Posttraumatic extension contracture of the knee (PECK) is common after knee injury. Initial management is conservative to improve the range of motion; if it fails, surgery may be necessary. This systematic review analyses existing literature on Judet quadricepsplasty for PECK. We will assess clinical outcomes, complications, patient satisfaction and factors that may influence its success., Methods: A search was conducted on 25 November 2023, adhering to preferred reporting items for systematic reviews and meta-analyses guidelines. PubMed, Embase and Google Scholar were used. Search strings were ([Judet] OR [quadricepsplasty]) AND (knee) AND (stiffness) and ([Judet] OR [quadricepsplasty]) AND (knee). Inclusion criteria: English articles focused on PECK, published between 2003 and 2023, and a minimum follow-up of 24 months. Exclusion criteria: case reports, alternative techniques, knee stiffness cases not only due to trauma, a sample size of <10 patients and articles not reporting functional outcomes., Results: Among selected studies, 239 patients were considered. The average time between injury and Judet was 27 months. The population was predominantly male; the mean follow-up was 33 months. An average intraoperative knee range of motion improvement of 79.1 degrees (confidence interval 76.9; 81.3) compared to the average preoperative starting value of 30.7 degrees was observed. This improvement decreased by 13.5 degrees at the first postoperative check and by an additional 2.4 degrees at the follow-up, while maintaining an average value of bending above 90 degrees., Conclusion: Judet quadricepsplasty appears an effective technique for the management of PECK. The heterogeneity of included studies and the absence of standardized outcome measures limit the ability to draw definitive conclusions., Level of Evidence: Level III., Competing Interests: The authors declare no conflict of interest., (© 2024 The Author(s). Journal of Experimental Orthopaedics published by John Wiley & Sons Ltd on behalf of European Society of Sports Traumatology, Knee Surgery and Arthroscopy. Traumatology, Knee Surgery and Arthroscopy.)

Published
2024
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46. Individualized support for breastfeeding in a case of elevated blood lead levels: A case report.

Author

Wallace Wu A, Mercedes J, and Markowitz M

Abstract

Introduction: Lead is a known toxicant that affects all tissues in the body, most notably the brains of developing children. However, there are limited data on the dynamics of lead transfer via breastmilk and its short-term and long-term consequences. Much of the available data come from areas of the world where numerous sources of lead complicate our understanding of the effects of lead exposure via breast milk., Case Presentation: We present trends in blood lead levels in a breastfeeding dyad, where the only source of lead exposure identified was prior to pregnancy, without other known ongoing lead exposures for the lactating parent or infant., Discussion and Conclusions: In this case, all lead exposure in the infant was presumed to come from in utero transmission and breastfeeding; and infant blood lead levels varied significantly with initiation and interruption of breastfeeding. This case is discussed in the context of current models for predicting transfer of lead in breastmilk and highlights pathophysiologic considerations for understanding lead transfer in the breastfeeding dyad., Competing Interests: The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (© 2024 The Authors.)

Published
2024
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47. Syndromic Surveillance in Public Health Emergencies: A Systematic Analysis of Cases Related to Exposure to 2023 Floodwaters in Romagna, Italy.

Author

Montalti M, Fabbri M, Angelini R, Bakken E, Morri M, Tamarri F, Reali C, Soldà G, Silvestrini G, and Lenzi J

Abstract

Background: In May 2023, Romagna, Italy, faced a devastating flood resulting in 16 fatalities, forced displacement of 26,000 citizens, and significant economic losses. Due to potential water contamination, implementing public health strategies became imperative for the Local Health Authority to mitigate the health consequences, analyze the flood's impact on the local population's health, and detect early anomalies requiring timely public health interventions., Methods: Between June and July 2023, general practitioners who were part of the RespiVirNet surveillance network completed weekly structured forms. These forms collected data on individuals exposed or not to floodwaters and clinical syndromes. Rates per 1000 resident population aged > 14 were stratified by district, week of observation, and symptomatology. Missing data were addressed by imputation using second-order autoregressive modeling., Results: An incidence of 3.52 syndromes potentially related to flood water exposure per 1000 individuals (95% CI 2.82-4.35) was estimated. Ravenna, the city most affected by the flood, recorded the highest rate (6.05 per 1000, 95% CI 4.59-7.82). Incidence decreased in the weeks post-event. Anxiety, or trauma and stress symptoms, exhibited higher rates among the exposed, diminishing over weeks. The incidence for the non-exposed (12.76 per 1000, 95% CI 10.55-15.29) showed no significant territorial differences compared to the exposed ones., Conclusions: Syndromic surveillance provided timely information on the flood's health impact, revealing a higher incidence of individual syndromes among the non-exposed. This study contributes to guiding the implementation of future public health preparedness and response strategies for populations facing similar natural disasters.

Published
2024
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48. Schwann cell-secreted PGE 2 promotes sensory neuron excitability during development.

Author

Kantarci H, Elvira PD, Thottumkara AP, O'Connell EM, Iyer M, Donovan LJ, Dugan MQ, Ambiel N, Granados A, Zeng H, Saw NL, Brosius Lutz A, Sloan SA, Gray EE, Tran KV, Vichare A, Yeh AK, Münch AE, Huber M, Agrawal A, Morri M, Zhong H, Shamloo M, Anderson TA, Tawfik VL, Du Bois J, and Zuchero JB

Subjects
Animals, Mice, Signal Transduction, Schwann Cells metabolism, Dinoprostone metabolism, Sensory Receptor Cells metabolism, Action Potentials
Abstract

Electrical excitability-the ability to fire and propagate action potentials-is a signature feature of neurons. How neurons become excitable during development and whether excitability is an intrinsic property of neurons remain unclear. Here, we demonstrate that Schwann cells, the most abundant glia in the peripheral nervous system, promote somatosensory neuron excitability during development. We find that Schwann cells secrete prostaglandin E 2 , which is necessary and sufficient to induce developing somatosensory neurons to express normal levels of genes required for neuronal function, including voltage-gated sodium channels, and to fire action potential trains. Inactivating this signaling pathway in Schwann cells impairs somatosensory neuron maturation, causing multimodal sensory defects that persist into adulthood. Collectively, our studies uncover a neurodevelopmental role for prostaglandin E 2 distinct from its established role in inflammation, revealing a cell non-autonomous mechanism by which glia regulate neuronal excitability to enable the development of normal sensory functions., Competing Interests: Declaration of interests J.D.B. is a cofounder and holds equity shares in SiteOne Therapeutics, Inc., a start-up company developing subtype-selective modulators of Na(V)s., (Copyright © 2024 Elsevier Inc. All rights reserved.)

Published
2024
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49. The Italian Consensus Conference on the role of rehabilitation for children and adolescents with leukemia, central nervous system tumors, and bone cancer, part 2: general principles for the rehabilitation treatment of motor function impairments.

Author

Rossi F, Botti S, Morri M, Asaftei S, Bertin D, Breggiè S, Casalaz R, Cervo M, Ciullini P, Coppo M, Cornelli A, Esposito M, Ferrarese M, Ghetti M, Longo L, Naretto G, Orsini N, Panzeri D, Pellegrini C, Peranzoni M, Perna A, Petit N, Picone F, Pittorru G, Raffa D, Recchiuti V, Rizzato L, Sarzana M, Sensi R, Fagioli F, and Ricci F

Subjects
Humans, Adolescent, Child, Italy, Female, Male, Child, Preschool, Central Nervous System Neoplasms rehabilitation, Bone Neoplasms rehabilitation, Leukemia rehabilitation, Leukemia therapy
Abstract

In Italy, 1400 children and 800 adolescents are diagnosed with cancer every year. About 80% of them can be cured but are at high risk of experiencing severe side effects, many of which respond to rehabilitation treatment. Due to the paucity of literature on this topic, the Italian Association of Pediatric Hematology and Oncology organized a Consensus Conference on the role of rehabilitation of motor impairments in children/adolescents affected by leukemia, central nervous system tumors, and bone cancer to state recommendations to improve clinical practice. This paper includes the consensus on the rehabilitation of children and adolescents with these cancers.

Published
2024
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50. Interstitial macrophages are a focus of viral takeover and inflammation in COVID-19 initiation in human lung.

Author

Wu TT, Travaglini KJ, Rustagi A, Xu D, Zhang Y, Andronov L, Jang S, Gillich A, Dehghannasiri R, Martínez-Colón GJ, Beck A, Liu DD, Wilk AJ, Morri M, Trope WL, Bierman R, Weissman IL, Shrager JB, Quake SR, Kuo CS, Salzman J, Moerner WE, Kim PS, Blish CA, and Krasnow MA

Subjects
Humans, SARS-CoV-2, Macrophages, Inflammation, RNA, Viral, Lung, COVID-19
Abstract

Early stages of deadly respiratory diseases including COVID-19 are challenging to elucidate in humans. Here, we define cellular tropism and transcriptomic effects of SARS-CoV-2 virus by productively infecting healthy human lung tissue and using scRNA-seq to reconstruct the transcriptional program in "infection pseudotime" for individual lung cell types. SARS-CoV-2 predominantly infected activated interstitial macrophages (IMs), which can accumulate thousands of viral RNA molecules, taking over 60% of the cell transcriptome and forming dense viral RNA bodies while inducing host profibrotic (TGFB1, SPP1) and inflammatory (early interferon response, CCL2/7/8/13, CXCL10, and IL6/10) programs and destroying host cell architecture. Infected alveolar macrophages (AMs) showed none of these extreme responses. Spike-dependent viral entry into AMs used ACE2 and Sialoadhesin/CD169, whereas IM entry used DC-SIGN/CD209. These results identify activated IMs as a prominent site of viral takeover, the focus of inflammation and fibrosis, and suggest targeting CD209 to prevent early pathology in COVID-19 pneumonia. This approach can be generalized to any human lung infection and to evaluate therapeutics., (© 2024 Wu et al.)

Published
2024
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