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1. Subacromial balloon spacer for irreparable rotator cuff tears of the shoulder (START:REACTS): a group-sequential, double-blind, multicentre randomised controlled trial

Author

Metcalfe, Andrew, Parsons, Helen, Parsons, Nicholas, Arif, Azra, Arnold, Susanne, Bhabra, Gev, Brown, Jaclyn, Bora, Sunayna, Bush, Howard, Drew, Stephen, Fox, Jo, Gemperlé Mannion, Elke, Haque, Aminul, Hutchinson, Charles, Jones, Ceri, Kearney, Rebecca, Khan, Iftekhar, Lawrence, Thomas, Mason, James, McGowan, Kerri, Modi, Chetan, Rahman, Bushra, Rahman, Usama, Ramirez, Maria, Spocinska, Marta, Stallard, Nigel, Teuke, Joanna, Thayalan, Varjithan, Ul-Rahman, Sumayyah, Viswanath, Aparna, Underwood, Martin, Packham, Iain, Barnett, Elizabeth, Witham, Rian, Crowther, Mark, Murphy, Richard, Coates, Katherine, Morley, Josephine, Barnfield, Stephen, Gill, Sukhdeep, Jones, Alistair, Halliday, Ruth, Dunn, Sarah, Fagg, James, Dacombe, Peter, Nanda, Rajesh, Wilson, Deborah, Boulton, Lesley, Liow, Raymond, Jeavons, Richard, Meddes, Andrea, Kang, Niel, Dehghani, Leila, Nacorda, Aileen, Punnoose, Anuj, Ferran, Nicholas, Adewetan, Gbadebo, Adedoyin, Temi, Pall, Arun, Sala, Matthew, Zaman, Tariq, Hartley, Richard, a-Sayyad, Charif, Vamplew, Luke, Howe, Elizabeth, Bokor, Norbert, Corbett, Steve, Moverley, Robert, Cox, Elise, Donaldson, Oliver, Jones, Michael, Wood, Diane, Perry, Jess, Lewis, Alison, Howard, Linda, Beesley, Kate, Harries, Luke, Elmorsy, Ahmed, Wilcocks, Katherine, Shean, Kate, Diment, Sarah, Pidgeon, Helen, King, Victoria, Sjolin, Soren, Williams, Angharad, Kellett, Joanne, Young, Lora, Dunne, Michael, Lockwood, Tom, Curtis, Mark, Siddiqui, Nashat, Mckenley, India, Morrison, Sarah, Morrison, Charlotte, O'Brien, Tracey, Bradley, Isabel, Lambatan, Kenneth, Kelly, Cormac, Perkins, Charlotte, Jones, Teresa, Rowlands, Tessa, Collins, Dawn, Nicholas, Claire, Birch, Claire, Lloyd -Evans, Julie, Akhbari, Pouya, Edakalathu, Jefin Jose, Hand, Campbell, Cole, Andy, Prince, Debbie, Thorpe, Kerry, Rooke, Louise, Baggot, Maria, Morris, Matt, Ivanova, Dima, Baker, David, Matthews, Tim, Falatoori, Jessica, Jarvis, Heather, Jones, Debbie, Williams, Matthew, Evans, Richard, Pullen, Huw, Hodkinson, Gemma, Vannet, Nicola, Davey, Alison, Poyser, Emma, Hall, Angela, Mehta, Hemang, Prakash Tokola, Devi, Connor, Clare, Jordan, Caroline, Ennis, Owain, Omar, Zohra, Lewis, Tracy, Owen, Angharad Lisa, Morgan, Andrew, Ponnada, Ravi, Al-Azzani, Waheeb, Williams, Carolyn, Knox, Liam, Singh, Harvinder, Lee, Tracy, Robinson, Kathryn, Kumar, Dileep, Armstrong, Alison, Majed, Addie, Falworth, Mark, Butt, David, Higgs, Deborah, Rudge, Will, Hughes, Ben, Hanison, Esther, Brooking, Deirdre, Patel, Amit, Symonds, Andrew, Gibson, Jenifer, Santiago, Rodney, Barlow, David, Lennon, Joanne, Smith, Christopher, Hall, Jane, Griffin, Emily, Lear, Rebecca, Thomas, William, Rose, David, Edkins, Janet, Samuel, Helen, Jahnich, Hagen, Geoghegan, John, Gooding, Ben, Hudson, Siobhan, Nightingale, Jess, Papanna, Madhavan, Briggs, Tom, Pugh, Rebecca, Neal, Amy, Warrem, Lisa, Maxwell, Veronica, Chadwick, Robert, Jaki, Thomas, Davies, Loretta, Gwilym, Stephen, Taylor, Rod, Abel, Geoffrey, Graham, John, Littlewood, Christopher, Wallace, Angus, Howard, Anthony, Fox, Josephine, and Lawrence, Tom

Published
2022
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8. Duraplasty in Traumatic Thoracic Spinal Cord Injury: Impact on Spinal Cord Hemodynamics, Tissue Metabolism, Histology, and Behavioral Recovery Using a Porcine Model

Author

Streijger, Femke, primary, Kim, Kyoung-Tae, additional, So, Kitty, additional, Manouchehri, Neda, additional, Shortt, Katelyn, additional, Okon, Elena B., additional, Morrison, Charlotte, additional, Fong, Allan, additional, Gupta, Rishab, additional, Allard Brown, Aysha, additional, Tigchelaar, Seth, additional, Sun, Jenny, additional, Liu, Ella, additional, Keung, Martin, additional, Daly, Chris D., additional, Cripton, Peter A., additional, Sekhon, Mypinder S., additional, Griesdale, Donald E., additional, and Kwon, Brian K., additional

Published
2021
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9. Science: Curriculum Guide for Teaching Gifted Children Science in Grades One Through Three.

Author

California State Dept. of Education, Sacramento. Div. of Special Education. and Morrison, Charlotte

Abstract

The curriculum guide for teaching science to gifted primary grade children in California focuses on natural science, with an emphasis on ecology. Provided are a general overview of the unit, a set of behavioral objectives, a list of generalizations and concepts, a sample teaching-learning plan for the complete unit, and eight sample lesson plans. Each lesson takes up a different ecological topic: substratum, animal movement, seed dispersal, temperature's influence on environment, light, food, water, and erosion. Each lesson plan includes behavioral objectives, teaching strategies, suggested questions and activities, and suggested resource materials. (KW)

Published
1970

12. Characterization of Lower Urinary Tract Dysfunction after Thoracic Spinal Cord Injury in Yucatan Minipigs

Author

Keung, Martin S., primary, Streijger, Femke, additional, Herrity, April, additional, Ethridge, Jay, additional, Dougherty, Susan M., additional, Aslan, Sevda, additional, Webster, Megan, additional, Fisk, Shera, additional, Deegan, Emily G., additional, Tessier-Cloutier, Basile, additional, Chen, Kuan-Yin N., additional, Morrison, Charlotte, additional, Okon, Elena B., additional, Tigchelaar, Seth, additional, Manouchehri, Neda, additional, Kim, Kyoung-Tae, additional, Shortt, Katelyn, additional, So, Kitty, additional, Damaser, Margot S., additional, Sherwood, Leslie C., additional, Howland, Dena R., additional, Boakye, Max, additional, Hubscher, Charles, additional, Stothers, Lynn, additional, Kavanagh, Alex, additional, and Kwon, Brian K., additional

Published
2021
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15. A porcine model for studying the cardiovascular consequences of high‐thoracic spinal cord injury

Author

West, Christopher R., primary, Poormasjedi‐Meibod, Malihe‐Sadat, additional, Manouchehri, Neda, additional, Williams, Alexandra M., additional, Erskine, Erin L., additional, Webster, Megan, additional, Fisk, Shera, additional, Morrison, Charlotte, additional, Short, Katelyn, additional, So, Kitty, additional, Cheung, Amanda, additional, Streijger, Femke, additional, and Kwon, Brian K., additional

Published
2020
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16. Differences in Morphometric Measures of the Uninjured Porcine Spinal Cord and Dural Sac Predict Histological and Behavioral Outcomes after Traumatic Spinal Cord Injury

Author

Kim, Kyoung-Tae, primary, Streijger, Femke, additional, So, Kitty, additional, Manouchehri, Neda, additional, Shortt, Katelyn, additional, Okon, Elena Borisovna, additional, Tigchelaar, Seth, additional, Fong, Allan, additional, Morrison, Charlotte, additional, Keung, Martin, additional, Sun, Jenny, additional, Liu, Ella, additional, Cripton, Peter Alexander, additional, and Kwon, Brian K., additional

Published
2019
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19. A Review of the Literature on Test Use.

Author

California Univ., Los Angeles. Center for the Study of Evaluation. and Lazar-Morrison, Charlotte

Abstract

This report was developed in the Test Use Project at the Center for the Study of Evaluation. The general goal of the project is to examine and describe the features and applications of tests and other assessment methods that contribute to the improvement of instruction. It is, therefore, examining the nature of current assessment practice, the kinds of information such practice yields, the factors influencing the use of the information, the kinds of uses made, and the costs associated with assessment. The first phase of the project (December 1979 to November 1981) consists primarily of a national survey of teachers and principals on the kind of issues suggested above. The design of the phase 1 national survey has been influenced by a variety of project planning activities. This report deals with one of these activities--a review of the literature on test use. This document integrates the literature reviewed and is intended to be selective rather than exhaustive. The focus is on: (1) the nature of current testing practices; (2) factors influencing the use of test results; and (3) costs associated with testing. (Author/GK)

Published
1980

22. Proceedings of the Twentieth Biennial Council of Pi Lambda Theta Teachers College, Columbia University New York City August 21-24, 1957

Author

Wiles, Marion E., Baxter, Bernice, HUNGATE, THAD L., FENNER, MILDRED SANDISON, Rose, Muriel Anderson, ACTON, NORMAN, Donne, John, CORYELL, GLADYS A., VOPNI, SYLVIA, Biggy, M. Virginia, Knowles, Lois, Pearson, Helen R., Olson, M. Adeline, Tatum, Beulah Benton, Johnson, Carmen, Seagoe, May, Hamilton, Frances, Wulfekammer, Verna, Baymiller, Vera Naomi, Carpenter, Bernice, Detlor, Marjorie B., Handy, M. Pauline, Johnson, Inez W., Scott, Esther A., Skjelstad, Vinette E., Beck, Frances J., Campbell, Joan, Carr, Constance, Cummings, Virginia, Dakin, Dorothy, Ellerman, Mary, Elwood, Mary, MacLeod, Alinda C., Platt, Doris H., Sollenberger, Lucille F., York, Katharine M., Hartley, Helene, Jones, Olwen M., Strang, Ruth, Walker, Helen, Watson, Gladys H., Lyons, Catherine A. V., Smith, Margaret Ruth, Adams, Abby, Broderick, Catherine M., Crawford, Gwendolyn, Cunningham, Martha, Herold, Talitha, Loesche, Marion S., Lofgren, Ruth, Logan, Lillian S., Mouradian, Esther, Oliverio, Mary Ellen, Patterson, Mary-Ellen, Smith, Mary Jane, Stewart, Maude, Throop, Nancy, Toomey, Gladys W., Beltramo, Louise, Bourne, Peggy, Bowman, Susan, Carpenter, Marjorie, Cockefair, Carolyn B., Glace, Margaret F. S., Good, Suzanne, Karnes, Merle, Linskie, Rosella, Lucas, Lee, Luthy, Annette, Noel, Doris, Parker, Carolyn, Pine, Mary A. Callahan, Saupe, Mildred W., Stasney, Martha, Stewart, Marcia, Barnes, Thelma I., Ceccarini, Frances, Coy, Nora Parker, Damon, Patricia, Dillon, Helen, Fay, Sara Ann, Hall, Edythe K., Hawkins, Katharine, Larson, Edith, Moore, Marie A., Morrison, Charlotte, Noble, Jeanne L., Owen, Kathleen, Rietz, Dorothy R., Sanderson, Marjorie E., Taylor, Juanita M., Todd, Vivian E., Warner, Welcome A., Wolfe, Ethel M., Thompson, Helen M., Babb, Evelyn M., Beatty, Angela Mensing, Cuskaden, Clarice, Dicke, Mildred, Frangen, Betty, Meilachowitz, Mindelle, Prouty, Mabel G., Razzano, Antoinette, Solomon, Ruth H., Woodworth, Margot, Kitchens, Nellie Mae, Kirkpatrick, Frances, Alvather, Winifred, Coleman, Mary E., Holmes, Chrystal, Keily, Helen J., Ling, Shata, Van Wagenen, Beulah C., Chisholm, Thelma, Efraemson, Margaret W., Shott, Mildred H., Hooper, Laura, Anderson, Ruth I., Apostol, Panoria, Hosack, Blanche J., Koivisto, Helmi, Lenahan, Mariella L., Nelsen, Alice R., O'Connor, Anna R., Raabe, Margaret C., and Wildman, Pauline J.

Published
1957

24. Active site specificity profiling datasets of matrix metalloproteinases (MMPs) 1, 2, 3, 7, 8, 9, 12, 13 and 14

Author

Eckhard, Ulrich, primary, Huesgen, Pitter F., additional, Schilling, Oliver, additional, Bellac, Caroline L., additional, Butler, Georgina S., additional, Cox, Jennifer H., additional, Dufour, Antoine, additional, Goebeler, Verena, additional, Kappelhoff, Reinhild, additional, auf dem Keller, Ulrich, additional, Klein, Theo, additional, Lange, Philipp F., additional, Marino, Giada, additional, Morrison, Charlotte J., additional, Prudova, Anna, additional, Rodriguez, David, additional, Starr, Amanda E., additional, Wang, Yili, additional, and Overall, Christopher M., additional

Published
2016
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25. Active site specificity profiling of the matrix metalloproteinase family: Proteomic identification of 4300 cleavage sites by nine MMPs explored with structural and synthetic peptide cleavage analyses

Author

Eckhard, Ulrich, primary, Huesgen, Pitter F., additional, Schilling, Oliver, additional, Bellac, Caroline L., additional, Butler, Georgina S., additional, Cox, Jennifer H., additional, Dufour, Antoine, additional, Goebeler, Verena, additional, Kappelhoff, Reinhild, additional, Keller, Ulrich auf dem, additional, Klein, Theo, additional, Lange, Philipp F., additional, Marino, Giada, additional, Morrison, Charlotte J., additional, Prudova, Anna, additional, Rodriguez, David, additional, Starr, Amanda E., additional, Wang, Yili, additional, and Overall, Christopher M., additional

Published
2016
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27. Post-translational modifications and expression stability of gpi-anchored and secreted forms of a recombinant metalloproteinase

Author

Morrison, Charlotte J.

Subjects
parasitic diseases
Abstract

The majority of recombinant proteins are produced as soluble secreted proteins. An alternative approach involves expressing recombinant proteins on the cell surface as glycosylphosphatidylinositol (GPI)-anchored proteins and harvesting with phosphatidylinositolphospholipase C. Leishmania GP63 is a GPI-anchored zinc metalloproteinase that is synthesized as a preproprotein and has three potential sites for N-linked glycosylation. Recombinant GP63 was produced in Chinese hamster ovary (CHO) cells as both a GPI-anchored and secreted protein, to investigate the differences in expression levels, stability and post-translational modifications. The expression of both proteolyrically active GP63 (GP63WT) and an active site mutant of GP63 (GP63E265D) was investigated. Flow cytometry was used to follow the stability of GP63WT and GP63E265D expression on the cell surface. Expression of GP63WT was found to be unstable whether or not methotrexate (MTX) selection was maintained. In contrast expression of GP63E265D was stable under MTX selection. In the absence of selection the decline in GP63E265D expression was more gradual than the loss of GP63WT expression. Loss of GP63 expression resulted in higher growth rate nonproducer populations. Expression of recombinant GP63 on the surface of CHO cells enabled a quantitative approach to evaluate expression stability during long-term culture. Comparison of producing and nonproducing populations has given insight into the mechanisms involved in loss of recombinant protein expression. Secreted GP63 production rates were over 20 fold higher than membrane expressed protein, however the post-translational modifications of secreted and membrane expressed proteins were different. GP63 was secreted in a latent form that retained the pro-region normally processed during cell surface expression. Fast atom bombardment-mass spectrometry of the N-linked glycans isolated from both secreted and membrane expressed GP63 showed that the predominant structures were complex biantennary types, however the glycan profiles showed dramatic differences. The degree of sialylation of the membrane form was greatly reduced and the core fucosylation of biantennary structures was increased compared to the secreted form. Glycans isolated from membrane expressed protein also contained poly-N-acetyllactosamine repeats. Residence times in the secretory pathway were similar for both secreted and membrane protein. These changes in post-translational modifications represent important factors to be considered when modifying membrane expressed protein for secreted production.

Published
1997
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30. Stromal regulation of vessel stability by MMP14 and TGFβ

Author

Sounni, Nor E., primary, Dehne, Kerstin, additional, van Kempen, Leon, additional, Egeblad, Mikala, additional, Affara, Nesrine I., additional, Cuevas, Ileana, additional, Wiesen, Jane, additional, Junankar, Simon, additional, Korets, Lidiya, additional, Lee, Jake, additional, Shen, Jennifer, additional, Morrison, Charlotte J., additional, Overall, Christopher M., additional, Krane, Stephen M., additional, Werb, Zena, additional, Boudreau, Nancy, additional, and Coussens, Lisa M., additional

Published
2010
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41. High quality CLE.

Author

Morrison, Charlotte

Subjects
Law -- Study and teaching (Continuing education)
Published
1995

48. Pivotal Molecular Determinants of Peptidic and Collagen Triple Helicase Activities Reside in the S3' Subsite of Matrix Metalloproteinase 8 (MMP-8).

Author

Pelman, Gayle R., Morrison, Charlotte J., and Overall, Christopher M.

Subjects
*METALLOPROTEINASES, *COLLAGEN, *CELLULAR control mechanisms, *EXTRACELLULAR matrix proteins, *CELL adhesion, *CYTOKINES, *GROWTH factors, *NUCLEIC acids, *RNA, *INTERLEUKIN-8, *CHEMOKINES
Abstract

Here, we demonstrate the expression of carcinoembryonic antigen-related cell adhesion molecule-1 (CEACAM1) in angiogenic sprouts but not in large mother blood vessels within tumor tissue. Correspondingly, only human microvascular endothelial cells involved in in vitro tube formation exhibit CEACAM1. CEACAM1-overexpressing versus CEACAM1-silenced human microvascular endothelial cells were used in migration and tube formation assays. CEACAM1-overexpressing microvascular endothelial cells showed prolonged survival and increased tube formation when they were stimulated with vascular endothelial growth factor (VEGF), whereas CEACAM1 silencing via small interfering RNA blocks these effects. Gene array and LightCycler analyses show an up-regulation of angiogenic factors such as VEGF, VEGF receptor 2, angiopoietin-1, angiopoietin-2, tie-2, angiogenin, and interleukin-8 but a down-regulation of collagen XVIII/endostatin and Tie-1 in CEACAM1-overexpressing microvascular endothelial cells. Western blot analyses confirm these results for VEGF and endostatin at the protein level. These results suggest that constitutive expression of CEACAM1 in microvascular endothelial cells switches them to an angiogenic phenotype, whereas CEACAM1 silencing apparently abrogates the VEGF-induced morphogenetic effects during capillary formation. Thus, strategies targeting the endothelial up-regulation of CEACAM1 might be promising for antiangiogenic tumor therapy. [ABSTRACT FROM AUTHOR]

Published
2005
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