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12. Association between Physical Fitness and Academic Achievement in a Cohort of Danish School Pupils

Author

Andersen, Mikkel P., Mortensen, Rikke N., Vardinghus-Nielsen, Henrik, Franch, Jesper, Torp-Pedersen, Christian, and Bøggild, Henrik

Abstract

Background: Time spent on physical activity in elementary school has been altered to improve core academics. However, little is known about the relationship between physical fitness and academic achievement. We examined the association between physical fitness and academic achievement and investigated the influence of parental socioeconomic status and ethnicity. Methods: Participants were 542 girls and 577 boys aged 13 to 15 residing in the Danish municipality of Aalborg. A watt-max cycle ergometer test was completed to evaluate physical fitness as represented by VO[subscript 2]max (mL·kg[superscript -1]·min[superscript -1]). Academic achievement was measured 1 school year later through a series of mandatory exams within the humanities, sciences, and all obligatory defined exams. Parental income and education were drawn from nationwide registers. Linear regression models were used to investigate the association. Results: Adjusting for ethnicity and parental socioeconomic status, the effect size of the humanities was 0.08 grad/VO[subscript 2]max (95% Cl:0.05 to 0.11) for girls and 0.06 grad/VO[subscript 2]max (95% Cl:0.03 to 0.08) for boys. The effect size of the sciences was 0.09 grad/VO[subscript 2]max (95% Cl:0.05 to 0.13) for girls and 0.06 grad/VO[subscript 2]max (95% Cl:0.03 to 0.09) for boys. The effect size of the defined exams was 0.09 grad/VO[subscript 2]max (95% Cl:0.06 to 0.11) for girls and 0.06 grad/VO[subscript 2]max (95% Cl:0.03 to 0.08) for boys. Conclusion: We found a statistically significant positive association between physical fitness and academic achievement after adjusting for ethnicity and parental socioeconomic status.

Published
2016
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13. Mortensen, Rikke

Author

Mortensen, Rikke and Mortensen, Rikke

Published
2023

16. Prediction of cardiovascular events from systolic or diastolic blood pressure

Author

Talebi, Atefeh, Mortensen, Rikke Nørmark, Gerds, Thomas Alexander, Jeppesen, Jørgen Lykke, Torp-Pedersen, Christian, Talebi, Atefeh, Mortensen, Rikke Nørmark, Gerds, Thomas Alexander, Jeppesen, Jørgen Lykke, and Torp-Pedersen, Christian

Abstract

Over time, a focus on blood pressure has transferred from diastolic pressure to systolic pressure. Formal analyses of differences in predictive value are scarce. Our goal of the study was whether office SBP adds prognostic information to office DBP and whether both 24-h ambulatory SBP and 24-h ambulatory DBP is specifically important. The authors examined 2097 participants from a population cohort recruited in Copenhagen, Denmark. Cause-specific Cox regression was performed to predict 10-year person-specific absolute risks of fatal and non-fatal cardiovascular (CV) events. Also, the time-dependent area under the receiver operator curve (AUC) was utilized to evaluate discriminative ability. The calibration plots of the models (Hosmer-May test) were calculated as well as the Brier score which combines (discrimination and calibration). Adding both 24-h ambulatory SBP and 24-h ambulatory diastolic blood pressure did not significantly increase AUC for CV mortality and CV events. Moreover, adding both office SBP and office DBP did not significantly improve AUC for both CV mortality and CV events. The difference in AUC (95% confidence interval; p-value) was.26% (-.2% to.73%;.27) for 10-year CV mortality and.69% (-.09% to 1.46%;.082) for 10-year risk of CV events. The difference in AUC was.12% (-.2% to.44%;.46) for 10-year CV mortality and.04% (-.35 to.42%;.85) for 10-year risk of CV events. Moreover, for both CV mortality and CV events, office SBP did not improve prognostic information to office DBP. In addition, the Brier scores of office BP in both CV mortality and CV events were.078 and.077, respectively. Furthermore, the Brier scores were.077 and.078 in CV mortality and CV events of 24-h ambulatory. For the average population as those participating in a population survey, the 10-year discriminative ability for long-term predictions of CV death and CV events is not improved by adding systolic to diastolic blood pressure. This finding is found for ambulatory as well a

Published
2022

19. Work exposure and associated risk of hospitalisation with pneumonia and influenza:A nationwide study

Author

Østergaard, Lauge, Mortensen, Rikke Nørmark, Kragholm, Kristian, Dalager-Pedersen, Michael, Koch, Kristoffer, Køber, Lars, Torp-Pedersen, Christian, Fosbøl, Emil, Østergaard, Lauge, Mortensen, Rikke Nørmark, Kragholm, Kristian, Dalager-Pedersen, Michael, Koch, Kristoffer, Køber, Lars, Torp-Pedersen, Christian, and Fosbøl, Emil

Abstract

Background: Pneumonia and influenza are major health concerns and constitute a high economic burden. However, few data are available on the associated risk of pneumonia and influenza and work exposure on a large population scale. Aim: This study aimed to examine the associated risk of pneumonia and influenza by type of work exposure. Methods: By cross-linking administrative Danish registries, we classified people in 10 different profession types. The main outcome was hospitalisation with pneumonia or influenza. A multivariable Poisson regression analysis was used to assess the associated incidence rate ratio (IRR) of being hospitalised with pneumonia or influenza by type of profession. Results: A total of 1,327,606 people added risk time to the analyses. In a multivariable model, work in day care, public transportation, sewers and nursing home care was associated with an increased risk of hospitalisation with pneumonia compared to work within public administration: IRR=1.20 (95% confidence interval (CI) 1.12–1.28), IRR=1.21 (95% CI 1.09–1.34), IRR=1.61 (95% CI 1.19–2.19) and IRR=1.10 (95% CI 1.03–1.18), respectively. In a multivariable analysis, people working within public transportation were associated with an increased risk of hospitalisation with influenza compared to people working within public administration: IRR=2.54 (95% CI 1.79–3.58). Conclusions: Working in day care, public transportation, sewers and nursing home care increased the associated risk of hospitalisation with pneumonia, and working within public transportation increased the associated risk of being hospitalised with influenza compared to working within public administration.

Published
2021

21. Additional file 1 of Associations of health literacy with socioeconomic position, health risk behavior, and health status: a large national population-based survey among Danish adults

Author

Svendsen, Majbritt Tang, Bak, Carsten Kronborg, Sørensen, Kristine, Pelikan, Jürgen, Riddersholm, Signe Juul, Skals, Regitze Kuhr, Mortensen, Rikke Nørmark, Maindal, Helle Terkildsen, Bøggild, Henrik, Nielsen, Gitte, and Torp-Pedersen, Christian

Abstract

Additional file 1: Table S1. Demographic and socioeconomic characteristics of Danish residents aged 25 years or older in 2016 and 2017 by interview or web-based distribution. Data are presented as medians with 25th (Q1) and 75th (Q3) percentiles (age) or number of residents and percentage (all others).

Published
2020
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22. SJP964974_Supplemental_Table – Supplemental material for Work exposure and associated risk of hospitalisation with pneumonia and influenza: A nationwide study

Author

Lauge Østergaard, Mortensen, Rikke Nørmark, Kragholm, Kristian, Dalager-Pedersen, Michael, Koch, Kristoffer, Køber, Lars, Torp-Pedersen, Christian, and Fosbøl, Emil

Subjects
111799 Public Health and Health Services not elsewhere classified, FOS: Health sciences
Abstract

Supplemental material, SJP964974_Supplemental_Table for Work exposure and associated risk of hospitalisation with pneumonia and influenza: A nationwide study by Lauge Østergaard, Rikke Nørmark Mortensen, Kristian Kragholm, Michael Dalager-Pedersen, Kristoffer Koch, Lars Køber, Christian Torp-Pedersen and Emil Fosbøl in Scandinavian Journal of Public Health

Published
2020
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23. Valve regurgitation in patients surviving endocarditis and the subsequent risk of heart failure

Author

Østergaard, Lauge, Dahl, Anders, Bruun, Niels Eske, Oestergaard, Louise Bruun, Lauridsen, Trine Kiilerich, Torp-Pedersen, Christian, Mortensen, Rikke, Smerup, Morten, Valeur, Nana, Koeber, Lars, Hassager, Christian, Ihlemann, Nikolaj, Fosbøl, Emil Loldrup, Østergaard, Lauge, Dahl, Anders, Bruun, Niels Eske, Oestergaard, Louise Bruun, Lauridsen, Trine Kiilerich, Torp-Pedersen, Christian, Mortensen, Rikke, Smerup, Morten, Valeur, Nana, Koeber, Lars, Hassager, Christian, Ihlemann, Nikolaj, and Fosbøl, Emil Loldrup

Abstract

Background Significant valve regurgitation is common in patients surviving native valve infective endocarditis (IE), however the associated risk of heart failure (HF) subsequent to hospital discharge after IE is sparsely described. Methods We linked data from the East Danish Endocarditis Registry with administrative registries from 2002 to 2016 and included patients treated medically for IE who were discharged alive. Left-sided valve regurgitation was assessed by echocardiography at IE discharge and examined for longitudinal risk of HF. Multivariable adjusted Cox analysis was used to assess the associated risk of HF in patients with regurgitation (moderate or severe) compared with patients without regurgitation. Results We included 192 patients, 87 patients with regurgitation at discharge (30 with aortic regurgitation and 57 with mitral regurgitation) and 105 patients without. The cumulative risk of HF at 5 years of follow-up was 28.7% in patients with regurgitation at IE discharge and 12.4% in patients without regurgitation; the corresponding multivariable adjusted HR was 3.53 (95% CI 1.72 to 7.25). We identified an increased associated risk of HF for patients with aortic regurgitation (HR=2.91, 95% CI 1.14 to 7.43) and mitral regurgitation (HR=3.95, 95% CI 1.80 to 8.67) compared with patients without regurgitation. During follow-up, 21.9% and 5.7% underwent left-sided valve surgery among patients with and without regurgitation. Conclusion In patients surviving IE, treated medically, we observed that severe or moderate left-sided native valve regurgitation was associated with a significantly higher risk of HF compared with patients without regurgitation at IE discharge. Close monitoring of these patients is needed to initiate surgery timely.

Published
2020

27. Uncertainty in classification of death from fatal myocardial infarction: A nationwide analysis of regional variation in incidence and diagnostic support

Author

Svendsen, Majbritt Tang, primary, Bøggild, Henrik, additional, Skals, Regitze Kuhr, additional, Mortensen, Rikke Nørmark, additional, Kragholm, Kristian, additional, Hansen, Steen Møller, additional, Riddersholm, Signe Juel, additional, Nielsen, Gitte, additional, and Torp-Pedersen, Christian, additional

Published
2020
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29. Relationship between heart failure, concurrent chronic obstructive pulmonary disease andbeta-blocker use:A Danish nationwide cohort study

Author

Sessa, Maurizio, Mascolo, Annamaria, Mortensen, Rikke Nørmark, Andersen, Mikkel Porsborg, Rosano, Giuseppe Massimo Claudio, Capuano, Annalisa, Rossi, Francesco, Gislason, Gunnar, Enghusen-Poulsen, Henrik, Torp-Pedersen, Christian, Sessa, Maurizio, Mascolo, Annamaria, Mortensen, Rikke Nørmark, Andersen, Mikkel Porsborg, Rosano, Giuseppe Massimo Claudio, Capuano, Annalisa, Rossi, Francesco, Gislason, Gunnar, Enghusen-Poulsen, Henrik, and Torp-Pedersen, Christian

Subjects
Male, Clinical guidelines, Adrenergic beta-1 Receptor Agonists/therapeutic use, Time Factors, Denmark, Cause of Death/trends, Heart failure, Comorbidity, Metoprolol/therapeutic use, Journal Article, Humans, Bisoprolol/therapeutic use, Non-cardio-selective β-blockers, Registries, Clinical guideline, Retrospective Studies, Aged, Chronic obstructive pulmonary disease, Heart Failure/drug therapy, Pulmonary Disease, Chronic Obstructive/drug therapy, Denmark/epidemiology, Carvedilol/therapeutic use, Non-cardio-selective β-blocker, Hospitalization, Treatment Outcome, Nebivolol/therapeutic use, Female, Drug Therapy, Combination, Carvedilol, Cardiology and Cardiovascular Medicine, Follow-Up Studies
Abstract

AIMS: To compare the hazard of all-cause, chronic obstructive pulmonary disease (COPD) and heart failure (HF) hospitalization in carvedilol vs. metoprolol/bisoprolol/nebivolol users with COPD and concurrent HF from 2009 to 2012, and to evaluate the use and persistence in treatment of these β-blockers, their impact on the risk of COPD-related hospitalization, and the factors important for their selection.METHODS AND RESULTS: Cox and logistic regression were used for both unadjusted and adjusted analyses. Carvedilol users had a higher hazard of being hospitalized for HF compared with metoprolol/bisoprolol/nebivolol users in both the unadjusted [hazard ratio (HR) 1.74; 95% confidence interval (CI) 1.65-1.83] and adjusted (HR 1.61; 95% CI 1.52-1.70) analyses. No significant differences were found for all-cause and COPD hospitalization between the two groups. Carvedilol users had a significant lower restricted mean persistence time than metoprolol/bisoprolol/nebivolol users. Patients exposed to carvedilol had an odds ratio (OR) of 1.38 (95% CI 1.23-1.56) for being hospitalized due to COPD within 60 days after redeeming the first carvedilol prescription, which was similar to that observed in metoprolol/bisoprolol/nebivolol users (OR 1.37; 95% CI 1.27-1.48). Patients with concurrent chronic kidney disease had a higher probability of receiving carvedilol (OR 1.16; 95% CI 1.04-1.29).CONCLUSION: Carvedilol prescription carried an increased hazard of HF hospitalization and lower restricted mean persistence time among patients with COPD and concurrent HF. Additionally, we found a widespread phenomenon of carvedilol prescription at variance with the European Society of Cardiology guidelines and potential for improving the proportion of patients treated with β-blockers.

Published
2018
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31. Additional file 5: of Infancy weight gain, parental socioeconomic position, and childhood overweight and obesity: a Danish register-based cohort study

Author

Rotevatn, Torill, Overgaard, Charlotte, G. Melendez-Torres, Mortensen, Rikke, Ullits, Line, HøStgaard, Anna, Torp-Pedersen, Christian, and BøGgild, Henrik

Abstract

Comparison of populations with and without missing data on exposure and outcome. A table showing comparing populations with and without missing data on exposure and outcome on central variables. (DOCX 17 kb)

Published
2019
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32. Additional file 1: of Infancy weight gain, parental socioeconomic position, and childhood overweight and obesity: a Danish register-based cohort study

Author

Rotevatn, Torill, Overgaard, Charlotte, G. Melendez-Torres, Mortensen, Rikke, Ullits, Line, HøStgaard, Anna, Torp-Pedersen, Christian, and BøGgild, Henrik

Abstract

Tables of covariate distribution on maternal education. A table presenting how covariates are distributed across levels of maternal education. (DOCX 21 kb)

Published
2019
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33. Additional file 3: of Infancy weight gain, parental socioeconomic position, and childhood overweight and obesity: a Danish register-based cohort study

Author

Rotevatn, Torill, Overgaard, Charlotte, G. Melendez-Torres, Mortensen, Rikke, Ullits, Line, HøStgaard, Anna, Torp-Pedersen, Christian, and BøGgild, Henrik

Abstract

Results from logistic regression models conducted on the population with complete data. A table showing the results obtained from the logistic regression models when these are based on the population with complete data. (DOCX 22 kb)

Published
2019
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34. The relationship between serum potassium concentrations and electrocardiographic characteristics in 163,547 individuals from primary care

Author

Krogager, Maria Lukacs, Kragholm, Kristian, Skals, Regitze Kuhr, Mortensen, Rikke Normark, Polcwiartek, Christoffer, Graff, Claus, Nielsen, Jonas Bille, Kanters, Jorgen K., Holst, Anders Gaarsdal, Sogaard, Peter, Pietersen, Adrian, Torp-Pedersen, Christian, Hansen, Steen Moller, Krogager, Maria Lukacs, Kragholm, Kristian, Skals, Regitze Kuhr, Mortensen, Rikke Normark, Polcwiartek, Christoffer, Graff, Claus, Nielsen, Jonas Bille, Kanters, Jorgen K., Holst, Anders Gaarsdal, Sogaard, Peter, Pietersen, Adrian, Torp-Pedersen, Christian, and Hansen, Steen Moller

Abstract

Aims: Potassium disturbances are common and associated with increased morbidity and mortality, even in patients without prior cardiovascular disease. We examined six electrocardiographic (ECG) measures and their association to serum potassium levels. Methods and results: From the Copenhagen General Practitioners' Laboratory, we identified 163,547 individuals aged >= 16 years with a first available ECG and a concomitant serum potassium measurement during 2001-2011. Restricted cubic splines curves showed a non-linear relationship between potassium and the Fridericia corrected QT (QTcF) interval, T-wave amplitude, morphology combination score (MCS), PR interval, P-wave amplitude and duration. Therefore, potassium was stratified in two intervals K: 2.0-4.1 mmol/L and 4.2-6.0 mmol/L for further analyses. Within the low potassium range, we observed: QTcF was 12.8 ms longer for each mmol/L decrease in potassium (p < 0.0001); T-wave amplitude was 43.1 mu V lower for each mmol/L decrease in potassium (p < 0.0001); and MCS was 0.13 higher per mmol/L decrease in potassium (p < 0.001). Moreover, P-wave duration and PR interval were prolonged by 2.7 and 4.6 ms for each mmol/L decrease in potassium (p < 0.0001), respectively. Within the lowest potassium range (2.0-4.1 mmol/L) P-wave amplitude was 3.5 mu V higher for each mmol/L decrease in potassium (p < 0.0001). Within the high potassium range associations with the above-mentioned ECG parameters were much weaker. (C) 2018 Elsevier Inc. All rights reserved.

Published
2019

35. Associations between common ECG abnormalities and out-of-hospital cardiac arrest

Author

Søndergaard, Marc Meller, Nielsen, Jonas Bille, Mortensen, Rikke Nørmark, Gislason, Gunnar, Køber, Lars, Lippert, Freddy, Graff, Claus, Haunsø, Stig, Svendsen, Jesper Hastrup, Kragholm, Kristian Hay, Pietersen, Adrian Holger, Lind, Bent Struer, Hjortshøj, Søren Pihlkjær, Holst, Anders Gaarsdal, Struijk, Johannes Jan, Torp-Pedersen, Christian, Hansen, Steen Møller, Søndergaard, Marc Meller, Nielsen, Jonas Bille, Mortensen, Rikke Nørmark, Gislason, Gunnar, Køber, Lars, Lippert, Freddy, Graff, Claus, Haunsø, Stig, Svendsen, Jesper Hastrup, Kragholm, Kristian Hay, Pietersen, Adrian Holger, Lind, Bent Struer, Hjortshøj, Søren Pihlkjær, Holst, Anders Gaarsdal, Struijk, Johannes Jan, Torp-Pedersen, Christian, and Hansen, Steen Møller

Abstract

Background: Out-of-hospital cardiac arrest (OHCA) is often the first manifestation of unrecognised cardiac disease. ECG abnormalities encountered in primary care settings may be warning signs of OHCA.Objective: We examined the association between common ECG abnormalities and OHCA in a primary care setting.Methods: We cross-linked individuals who had an ECG recording between 2001 and 2011 in a primary care setting with the Danish Cardiac Arrest Registry and identified OHCAs of presumed cardiac cause.Results: A total of 326 227 individuals were included and 2667 (0,8%) suffered an OHCA. In Cox regression analyses, adjusted for age and sex, the following ECG findings were strongly associated with OHCA: ST-depression without concomitant atrial fibrillation (HR 2.79; 95% CI 2.45 to 3.18), left bundle branch block (LBBB; HR 3.44; 95% CI 2.85 to 4.14) and non-specific intraventricular block (NSIB; HR 3.15; 95% CI 2.58 to 3.83). Also associated with OHCA were atrial fibrillation (HR 1.89; 95% CI 1.63 to 2.18), Q-wave (HR 1.75; 95% CI 1.57 to 1.95), Cornell and Sokolow-Lyon criteria for left ventricular hypertrophy (HR 1.56; 95% CI 1.33 to 1.82 and HR 1.27; 95% CI 1.12 to 1.45, respectively), ST-elevation (HR 1.40; 95% CI 1.09 to 1.54) and right bundle branch block (HR 1.29; 95% CI 1.09 to 1.54). The association between ST-depression and OHCA diminished with concomitant atrial fibrillation (HR 1.79; 95% CI 1.42 to 2.24, p < 0.01 for interaction). Among patients suffering from OHCA, without a known cardiac disease at the time of the cardiac arrest, 14.2 % had LBBB, NSIB or ST-depression.Conclusions: Several common ECG findings obtained from a primary care setting are associated with OHCA.

Published
2019

36. Blood pressure, hazard ratio, and prediction

Author

Torp-Pedersen, Christian, Mortensen, Rikke, Jeppesen, Jørgen, Gerds, Thomas Alexander, Torp-Pedersen, Christian, Mortensen, Rikke, Jeppesen, Jørgen, and Gerds, Thomas Alexander

Published
2019

37. Risk factors for unfavourable postoperative outcome in patients with Crohn's disease undergoing right hemicolectomy or ileocaecal resection. An international audit by ESCP and S-ECCO

Author

El-Hussuna, A., Pinkney, T., Zmora, O., Frasson, M., Bhangu, A., Battersby, N., Chaudhri, S., Nepogodiev, D., Singh, B., Vennix, S., Altomare, D., Bemelman, W., Christensen, P., D'Hoore, A., Laurberg, S., Morton, D., Rubbini, M., Vaizey, C., Magill, L., Perry, R., Sheward, N., Nørmark Mortensen, Rikke, El-Hussuna, Alaa, Cillo, M., Estefania, D., Patron Uriburu, J., Ruiz, H., Salomon, M., Makhmudov, A., Selnyahina, L., Varabei, A., Vizhynis, Y., Claeys, D., Defoort, B., Muysoms, F., Pletinckx, P., Vergucht, V., Debergh, I., Feryn, T., Reusens, H., Nachtergaele, M., Francart, D., Jehaes, C., Markiewicz, S., Monami, B., Weerts, J., Bouckaert, W., Houben, B., Knol, J., Sergeant, G., Vangertruyden, G., Haeck, L., Lange, C., Sommeling, C., Vindevoghel, K., Castro, S., De Bruyn, H., Huyghe, M., De Wolf, E., Reynders, D., de Buck van Overstraeten, A., Wolthuis, A., Delibegovic, S., Christiani, A., Marchiori, M., Rocha de Moraes, C., Tercioti, V., Arabadjieva, E., Bulanov, D., Dardanov, D., Stoyanov, V., Yonkov, A., Angelov, K., Maslyankov, S., Sokolov, M., Todorov, G., Toshev, S., Georgiev, Y., Karashmalakov, A., Zafirov, G., Wang, X., Condic, D., Kraljik, D., Mrkovic, H., Pavkovic, V., Raguž, K., Bencurik, V., Holášková, E., Skrovina, M., Farkašová, M., Grolich, T., Kala, Z., Antos, F., Pruchova, V., Sotona, O., Chobola, M., Dusek, T., Ferko, A., Örhalmi, J., Hoch, J., Kocian, P., Martinek, L., Bernstein, I., Gotschalck Sunesen, K., Leunbach, J., Thorlacius-Ussing, O., Uth Oveson, A., Dahl Chirstensen, S., Gamez, V., Oeting, M., Schou Loeve, U., Ugianskis, A., Jessen, M., Krarup, P. M., Linde, K., Mirza, Q., Overgaard Stovring, J., Erritzøe, L., Loft Jakobsen, H., Lykke, J., Palmgren Colov, E., Husted Madsen, A., Linde Friis, T., Amstrup Funder, J., Dich, R., Kjær, S., Rasmussen, S., Schlesinger, N., Dilling Kjaer, M., Qvist, N., Khalid, A., Ali, G., Hadi, S., Rosell Walker, L., Kivelä, A., Lehtonen, T., Lepistö, A., Scheinin, T., Siironen, P., Kössi, J., Kuusanmäki, P., Tomminen, T., Turunen, A., Rautio, T., Vierimaa, M., Huhtinen, H., Karvonen, J., Lavonius, M., Rantala, A., Varpe, P., Cotte, E., Francois, Y., Glehen, O., Kepenekian, V., Passot, G., Maggiori, L., Manceau, G., Panis, Y., Gout, M., Rullier, E., van Geluwe, B., Chafai, N., Lefevre, J. H., Parc, Y., Tiret, E., Couette, C., Duchalais, E., Agha, A., Hornberger, M., Hungbauer, A., Iesalnieks, I., Weindl, I., Crescenti, F., Keller, M., Kolodziejski, N., Scherer, R., Sterzing, D., Bock, B., Boehm, G., El-Magd, M., Krones, C., Niewiera, M., Buhr, J., Cordesmeyer, S., Hoffmann, M., Krückemeier, K., Vogel, T., Schön, M., Baral, J., Lukoschek, T., Münch, S., Pullig, F., Horisberger, K., Kienle, P., Magdeburg, J., Post, S., Batzalexis, K., Germanos, S., Agalianos, C., Dervenis, C., Gouvas, N., Kanavidis, P., Kottikias, A., Katsoulis, I. E., Korkolis, D., Plataniotis, G., Sakorafas, G., Akrida, I., Argentou, M., Kollatos, C., Lampropoulos, C., Tsochatzis, S., Besznyák, I., Bursics, A., Egyed, T., Papp, G., Svastics, I., Atladottir, J., Möller, P., Sigurdsson, H., Stefánsson, T., Valsdottir, E., Andrews, E., Foley, N., Hechtl, D., Majeed, M., Mccourt, M., Hanly, A., Hyland, J., Martin, S., O'Connell, P. R., Winter, D., Connelly, T., Joyce, W., Wrafter, P., Berkovitz, R., Avital, S., Haj Yahia, I., Hermann, N., Shpitz, B., White, I., Lishtzinsky, Y., Tsherniak, A., Wasserberg, N., Horesh, N., Keler, U., Pery, R., Shapiro, R., Tulchinsky, H., Badran, B., Dayan, K., Iskhakov, A., Lecaros, J., Nabih, N., Angriman, I., Bardini, R., Pizzolato, E., Tonello, M., Arces, F., Balestri, R., Ceccarelli, C., Prosperi, V., Rossi, E., Giannini, I., Vincenti, L., Altomare, D. F., Di Candido, F., Di Iena, M., Guglielmi, A., Caputi-Iambrenghi, O., Marsanic, P., Mellano, A., Muratore, A., Annecchiarico, M., Bencini, L., Amore Bonapasta, S., Coratti, A., Guerra, F., Asteria, C. R., Boccia, L., Gerard, L., Pascariello, A., Manca, G., Marino, F., Casaril, A., Inama, M., Moretto, G., Bacchelli, C., Carvello, M., Mariani, N., Montorsi, M., Spinelli, A., Romairone, E., Scabini, S., Belli, A., Bianco, F., De Franciscis, S., Maria Romano, G., Delrio, P., Pace, U., Rega, D., Sassaroli, C., Scala, D., De Luca, R., Ruggieri, E., Elbetti, C., Garzi, A., Romoli, L., Scatizzi, M., Vannucchi, A., Curletti, G., Durante, V., Galleano, R., Mariani, F., Reggiani, L., Bellomo, R., Infantino, A., Franceschilli, L., Sileri, P., Clementi, I., Coletta, D., La Torre, F., Mingoli, A., Velluti, F., Di Giacomo, A., Fiorot, A., Massani, M., Padoan, L., Ruffolo, C., Caruso, S., Franceschini, F., Laessig, R., Monaci, I., Rontini, M., De Nardi, P., Elmore, U., Lemma, M., Rosati, R., Tamburini, A., De Luca, M., Sartori, A., Benevento, A., Bottini, C., Ferrari, C. C., Pata, F., Tessera, G., Pellino, G., Selvaggi, F., Lanzani, A., Romano, F., Sgroi, G., Steccanella, F., Turati, L., Yamamoto, T., Ancans, G., Gerkis, S., Leja, M., Pcolkins, A., Sivins, A., Latkauskas, T., Lizdenis, P., Saladžinskas, Ž., Švagždys, S., Tamelis, A., Razbadauskas, A., Sokolovas, M., Dulskas, A., Samalavicius, N., Jotautas, V., Mikalauskas, S., Poskus, E., Poskus, T., Strupas, K., Camenzuli, C., Cini, C., Predrag, A., Psaila, J., Spiteri, N., Buskens, C., de Groof, E. J., Gooszen, J., Tanis, P., Belgers, E., Davids, P., Furnee, E., Postma, E., Pronk, A., Smakman, N., Clermonts, S., Zimmerman, D., Omloo, J., van der Zaag, E., van Duijvendijk, P., Wassenaar, E., Bruijninckx, M., de Graff, E., Doornebosch, P., Tetteroo, G., Vermaas, M., Iordens, G., Knops, S., Toorenvliet, B., van Westereenen, H. 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Benevento, A, Bottini, C, Ferrari, Cc, Pata, F, Tessera, G, Pellino, G, Selvaggi, F, Lanzani, A, Romano, F, Sgroi, G, Steccanella, F, Turati, L, Yamamoto, T, Ancans, G, Gerkis, S, Leja, M, Pcolkins, A, Sivins, A, Latkauskas, T, Lizdenis, P, Saladžinskas, Ž, Švagždys, S, Tamelis, A, Razbadauskas, A, Sokolovas, M, Dulskas, A, Samalavicius, N, Jotautas, V, Mikalauskas, S, Poskus, E, Poskus, T, Strupas, K, Camenzuli, C, Cini, C, Predrag, A, Psaila, J, Spiteri, N, Buskens, C, de Groof, Ej, Gooszen, J, Tanis, P, Belgers, E, Davids, P, Furnee, E, Postma, E, Pronk, A, Smakman, N, Clermonts, S, Zimmerman, D, Omloo, J, van der Zaag, E, van Duijvendijk, P, Wassenaar, E, Bruijninckx, M, de Graff, E, Doornebosch, P, Tetteroo, G, Vermaas, M, Iordens, G, Knops, S, Toorenvliet, B, van Westereenen, Hl, Boerma, E, Coene, P, van der Harst, E, Van Der Pool, A, Raber, M, Melenhorst, J, de Castro, S, Gerhards, M, Arron, M, Bremers, A, de Wilt, H, Ferenschild, F, Yauw, S, Cense, H, Demirkiran, A, Hunfeld, M, Mulder, I, Nonner, J, Swank, H, van Wagensveld, B, Bolmers, M, Briel, J, van Geloven, A, van Rossem, C, Klemann, V, Konsten, J, Leenders, B, Schok, T, Bleeker, W, Gidwani, A, Lawther, R, Loughlin, P, Skelly, B, Spence, R, Brun, M, Helgeland, M, Ignjatovic, D, Øresland, T, Yousefi, P, Flåten Backe, I, Helmer Sjo, O, Nesbakken, A, Tandberg-Eriksen, M, Cais, A, Hallvard Traeland, J, Herikstad, R, Kørner, H, Lauvland, N, Jajtner, D, Kabiesz, W, Rak, M, Gmerek, L, Horbacka, K, Horst, N, Krokowicz, P, Kwiatkowski, A, Pasnik, K, Karcz, P, Romaniszyn, M, Rusek, T, Walega, P, Czarencki, R, Obuszko, Z, Sitarska, M, Wojciech, W, Zawadzki, M, Amado, S, Clara, P, Couceiro, A, Malaquias, R, Rama, N, Almeida, A, Barbosa, E, Cernadas, E, Duarte, A, Silva, P, Costa, S, Martinez Insua, C, Pereira, J, Pereira, C, Sacchetti, M, Carvalho Pinto, B, Jorge Vieira Sousa, P, Marques, R, Oliveira, A, Cardoso, R, Carlos, S, Corte-Real, J, Moniz Pereira, P, Souto, R, Carneiro, C, Marinho, R, Nunes, V, Rocha, R, Sousa, M, Leite, J, Melo, F, Pimentel, J, Ventura, L, Vila Nova, C, Copăescu, C, Bintintan, V, Ciuce, C, Dindelegan, G, Scurtu, R, Seicean, R, Domansky, N, Karachun, A, Moiseenko, A, Pelipas, Y, Petrov, A, Pravosudov, I, Aiupov, R, Akmalov, Y, Parfenov, A, Suleymanov, N, Tarasov, N, Jumabaev, H, Mamedli, Z, Rasulov, A, Aliev, I, Chernikovskiy, I, Kochnev, V, Komyak, K, Smirnov, A, Achkasov, S, Bolikhov, K, Shelygin, Y, Sushkov, O, Zapolskiy, A, Gvozdenovic, M, Jovanovic, D, Lausevic, Z, Cvetković, D, Maravić, M, Milovanovic, B, Stojakovic, N, Tripković, I, Mihajlovic, D, Nestorovic, M, Pecic, V, Petrovic, D, Stanojevic, G, Barisic, G, Dimitrijevic, I, Krivokapic, Z, Markovic, V, Popovic, M, Aleksic, A, Dabic, D, Kostic, I, Milojkovic, A, Perunicic, V, Lukic, D, Petrovic, T, Radovanovic, D, Radovanovic, Z, Cuk, Vm, Cuk, Vv, Kenic, M, Kovacevic, B, Krdzic, I, Korcek, J, Rems, M, Toplak, J, Escarrâ, J, Gil Barrionuevo, M, Golda, T, Kreisler Moreno, E, Zerpa Martin, C, Álvarez Laso, C, Cumplido, P, Padin, H, Baixauli Fons, J, Hernández-Lizoain, J, Martinez-Ortega, P, Molina-Fernández, M, Sánchez-Justicia, C, Antonio Gracia Solanas, J, Córdoba Díaz de Laspra, E, Echazarreta-Gallego, E, Elia-Guedea, M, Ramirez, J, Arredondo Chaves, J, Diez González, P, Elosua, T, Sahagún, J, Turienzo Frade, A, Álvarez Conde, J, Castrillo, E, Diaz Maag, R, Maderuelo, V, Saldarriaga, L, Aldrey Cao, I, Fernández Varela, X, Núñez Fernández, S, Parajó Calvo, A, Villar Álvarez, S, Blesa Sierra, I, Lozano, R, Márquez, M, Porcel, O, Menendez, P, Fernández Hevia, M, Flores Sigüenza, L, Jimenez Toscano, M, Lacy Fortuny, A, Ordoñez Trujillo, J, Espi, A, Garcia-Botello, S, Martín-Arévalo, J, Moro-Valdezate, D, Pla-Martí, V, Blanco-Antona, F, Abrisqueta, J, Ibañez Canovas, N, Lujan Mompean, J, Escolá Ripoll, D, Martinez Gonzalez, S, Parodi, J, Fernández López, A, Ramos Fernández, M, Castellvi Valls, J, Ortiz de Zarate, L, Ribas, R, Sabia, D, Viso, L, Alonso Gonçalves, S, José Gil Egea, M, Pascual Damieta, M, Pera, M, Salvans Ruiz, S, Bernal, J, Landete, F, Ais, G, Etreros, J, Aguiló Lucia, J, Boscá, A, Deusa, S, García Del Caño, J, Viciano, V, García-Armengol, J, Roig, J, Blas, J, Escartin, J, Fatás, J, Fernando, J, Ferrer, R, Arias Pacheco, R, García Flórez, L, Moreno Gijón, M, Otero Díez, J, Solar Garcia, L, Aguilar Teixido, F, Balaguer Ojo, C, Bargallo Berzosa, J, Lamas Moure, S, Enrique Sierra, J, Fermiñán, A, Herrerias, F, Rufas, M, Viñas, J, Codina-Cazador, A, Farrés, R, Gómez, N, Julià, D, Planellas, P, López, J, Luna, A, Maristany, C, Muñoz Duyos, A, Puértolas, N, Alcantara Moral, M, Serra-Aracil, X, Concheiro Coello, P, Gómez, D, Carton, C, Miguel, A, Reoyo Pascual, F, Valero Cerrato, X, Zambrano Muñoz, R, Cervera-Aldama, J, García González, J, Ramos-Prada, J, Santamaría-Olabarrieta, M, Urigüen-Echeverría, A, Coves Alcover, R, Espinosa Soria, J, Fernandez Rodriguez, E, Hernandis Villalba, J, Maturana Ibañez, V, De la Torre Gonzalez, F, Huerga, D, Pérez Viejo, E, Rivera, A, Ruiz Ucar, E, Garcia-Septiem, J, Jiménez, V, Jiménez Miramón, J, Ramons Rodriquez, J, Rodriguez Alvarez, V, Garcea, A, Ponchietti, L, Borda, N, Enriquez-Navascues, J, Saralegui, Y, Febles Molina, G, Nogues, E, Rodríguez Méndez, Á, Roque Castellano, C, Sosa Quesada, Y, Alvarez-Gallego, M, Pascual, I, Rubio-Perez, I, Diaz-San Andrés, B, Tone-Villanueva, F, Alonso, J, Cagigas, C, Castillo, J, Gómez, M, Martín-Parra, J, Mengual Ballester, M, Pellicer Franco, E, Soria Aledo, V, Valero Navarro, G, Caballero Rodríguez, E, Gonzalez De Chaves, P, Hernandez, G, Perez Alvarez, A, Soto Sanchez, A, Cesar Becerra Garcia, F, Guillermo Alonso Roque, J, López Rodríguez Arias, F, Del Valle Ruiz, Sr, Sánchez De La Villa, G, Compañ, A, García Marín, A, Nofuentes, C, Orts Micó, F, Pérez Auladell, V, Carrasco, M, Duque Perez, C, Gálvez-Pastor, S, Navarro Garcia, I, Sanchez Perez, A, Enjuto, D, Manuel Bujalance, F, Marcelin, N, Pérez, M, Serrano García, R, Cabrera, A, de la Portilla, F, Diaz-Pavon, J, Jimenez-Rodriguez, R, Vazquez-Monchul, J, Daza González, J, Gómez Pérez, R, Rivera Castellano, J, Roldán de la Rua, J, Errasti Alustiza, J, Fernandez, L, Romeo Ramirez, J, Sardon Ramos, J, Cermeño Toral, B, Alias, D, Garcia-Olmo, D, Guadalajara, H, Herreros, M, Pacheco, P, Del Castillo Díez, F, Lima Pinto, F, Martínez Alegre, J, Ortega, I, Picardo Nieto Antonio, A, Caro, A, Escuder, J, Feliu, F, Millan, M, Alos Company, R, Frangi Caregnato, A, Lozoya Trujillo, R, Rodríguez Carrillo, R, Ruiz Carmona, M, Alonso, N, Ambrona Zafra, D, Amilka Ayala Candia, B, Bonnin Pascual, J, Pineño Flores, C, Alcazar Montero, J, Angoso Clavijo, M, Garcia, J, Sanchez Tocino, J, Gómez-Alcazar, C, Costa-Navarro, D, Ferri-Romero, J, Rey-Riveiro, M, Romero-Simó, M, Arencibia, B, Esclapez, P, García-Granero, E, Granero, P, Medina Fernández, Fj, Gallardo Herrera, Ab, Diaz López, C, Navarro Rodriguez, E, Torres Tordera, E, Arenal, J, Citores, M, Marcos, J, Sánchez, J, Tinoco, C, Espin, E, Garcia Granero, A, Jimenez Gomez, L, Sanchez Garcia, J, Vallribera, F, Folkesson, J, Sköldberg, F, Bergman, K, Borgström, E, Frey, J, Silfverberg, A, Söderholm, M, Nygren, J, Segelman, J, Gustafsson, D, Lagerqvist, A, Papp, A, Pelczar, M, Abraham-Nordling, M, Ahlberg, M, Sjovall, A, Tengstrom, J, Hagman, K, Chabok, A, Ezra, E, Nikberg, M, Smedh, K, Tiselius, C, Al-Naimi, N, Dao Duc, M, Meyer, J, Mormont, M, Ris, F, Prevost, G, Villiger, P, Hoffmann, H, Kettelhack, C, Kirchhoff, P, Oertli, D, Weixler, B, Aytac, B, Leventoglu, S, Mentes, B, Yuksel, O, Demirbas, S, Busra Ozkan, B, Selçuk Özbalci, G, Sungurtekin, U, Gülcü, B, Ozturk, E, Yilmazlar, T, Challand, C, Fearnhead, N, Hubbard, R, Kumar, S, Arthur, J, Barben, C, Skaife, P, Slawik, S, Williams, M, Zammit, M, Barker, J, French, J, Sarantitis, I, Slawinski, C, Clifford, R, Eardley, N, Johnson, M, Mcfaul, C, Vimalachandran, D, Allan, S, Bell, A, Oates, E, Shanmugam, V, Brigic, A, Halls, M, Pucher, P, Stubbs, B, Agarwal, T, Chopada, A, Mallappa, S, Pathmarajah, M, Sugden, C, Brown, C, Macdonald, E, Mckay, A, Richards, J, Robertson, A, Kaushal, M, Patel, P, Tezas, S, Touqan, N, Ayaani, S, Marimuthu, K, Piramanayagam, B, Vourvachis, M, Iqbal, N, Korsgen, S, Seretis, C, Shariff, U, Arnold, S, Chan, H, Clark, E, Fernandes, R, Moran, B, Bajwa, A, Mcarthur, D, Cao, K, Cunha, P, Pardoe, H, Quddus, A, Theodoropoulou, K, Bolln, C, Denys, G, Gillespie, M, Manimaran, N, Reidy, J, Malik, Ai, Malik, A, Pitt, J, Aryal, K, El-Hadi, A, Lal, R, Pal, A, Velchuru, V, Oliveira Cunha, M, Thomas, M, Bains, S, Boyle, K, Miller, A, Norwood, M, Yeung, J, Goian, L, Gurjar, S, Saghir, W, Sengupta, N, Stewart-Parker, E, Bailey, S, Khalil, T, Lawes, D, Nikolaou, S, Omar, G, Church, R, Muthiah, B, Garrett, W, Marsh, P, Obeid, N, Chandler, S, Coyne, P, Evans, M, Hunt, L, Lim, J, Oliphant, Z, Papworth, E, Weaver, H, Cuiñas Leon, K, Williams, G, Hernon, J, Kapur, S, Moosvi, R, Shaikh, I, Swafe, L, Aslam, M, Evans, J, Ihedioha, U, Kang, P, Merchant, J, Hompes, R, Middleton, R, Broomfield, A, Crutten-Wood, D, Foster, J, Nash, G, Akhtar, M, Boshnaq, M, Eldesouky, S, Mangam, S, Rabie, M, Ahmed, J, Khan, J, Ming Goh, N, Shamali, A, Stefan, S, Thompson, C, Amin, A, Docherty, J, Lim, M, Walker, K, Watson, A, Hossack, M, Mackenzie, N, Paraoan, M, Alam, N, Daniels, I, Narang, S, Pathak, S, Smart, N, Al-Qaddo, A, Codd, R, Rutka, O, Bronder, C, Crighton, I, Davies, E, Raymond, T, Bookless, L, Griffiths, B, Plusa, S, Carlson, G, Harrison, R, Lees, N, Mason, C, Quayle, J, Branagan, G, Broadhurst, J, Chave, H, Sleight, S, Awad, F, Cruickshank, N, Joy, H, Boereboom, C, Daliya, P, Dhillon, A, Watson, N, Watson, R, Artioukh, D, Gokul, K, Javed, M, Kong, R, Sutton, J, Faiz, O, Jenkins, I, Leo, Ca, Samaranayake, Sf, Warusavitarne, J, Arya, S, Bhan, C, Mukhtar, H, Oshowo, A, Wilson, J, Duff, S, Fatayer, T, Mbuvi, J, Sharma, A, Cornish, J, Davies, L, Harries, R, Morris, C, Torkington, J, Knight, J, Lai, C, Shihab, O, Tzivanakis, A, Hussain, A, Luke, D, Padwick, R, Torrance, A, Tsiamis, A, Dawson, P, Balfour, A, Brady, R, Mander, J, Paterson, H, Chandratreya, N, Chu, H, Cutting, J, Vernon, S, Wai Ho, C, Andreani, S, Patel, H, Warner, M, Yan Qi Tan, J, Iqbal, A, Khan, A, Perrin, K, Raza, A, Tan, S., and 2015 European Society of Coloproctology collaborating, Group

Subjects
creatinine blood level, adverse event, Disease, open surgery, surgery, 0302 clinical medicine, hospital readmission, postoperative complication, resection, Crohn's disease, Resection, Surgery, outcome, parenteral nutrition, postoperative complications, C reactive protein, adult, Gastroenterology, creatinine, Crohn disease, cohort analysis, female, priority journal, risk factor, 030220 oncology & carcinogenesis, 030211 gastroenterology & hepatology, abdominal abscess, anastomosis leakage, prospective study, medicine.medical_specialty, side to side anastomosis, surgical infection, reoperation, Anastomosis, Article, NO, 03 medical and health sciences, intestine resection, length of stay, male, medicine, intraoperative period, follow up, ileocecal resection, controlled study, human, Adverse effect, outcome assessment, preoperative period, ta3126, business.industry, Postoperative complication, Odds ratio, medicine.disease, surgical margin, major clinical study, Confidence interval, hemicolectomy, Parenteral nutrition, protein blood level, business, abscess drainage
Abstract

Aim: Patient- and disease-related factors, as well as operation technique, all have the potential to impact on postoperative outcome in Crohn's disease. The available evidence is based on small series and often displays conflicting results. The aim was to investigate the effect of preoperative and intra-operative risk factors on 30-day postoperative outcome in patients undergoing surgery for Crohn's disease. Method: This was an international prospective snapshot audit including consecutive patients undergoing right hemicolectomy or ileocaecal resection. The study analysed a subset of patients who underwent surgery for Crohn's disease. The primary outcome measure was the overall Clavien–Dindo postoperative complication rate. The key secondary outcomes were anastomotic leak, reoperation, surgical site infection and length of stay in hospital. Multivariable binary logistic regression analyses were used to produce odds ratios and 95% confidence intervals. Results: In all, 375 resections in 375 patients were included. The median age was 37 and 57.1% were women. In multivariate analyses, postoperative complications were associated with preoperative parenteral nutrition (OR 2.36, 95% CI 1.10–4.97), urgent/expedited surgical intervention (OR 2.00, 95% CI 1.13–3.55) and unplanned intra-operative adverse events (OR 2.30, 95% CI 1.20–4.45). The postoperative length of stay in hospital was prolonged in patients who received preoperative parenteral nutrition (OR 31, 95% CI 1.08–1.61) and those who had urgent/expedited operations (OR 1.21, 95% CI 1.07–1.37). Conclusion: Preoperative parenteral nutritional support, urgent/expedited operation and unplanned intra-operative adverse events were associated with unfavourable postoperative outcome. Enhanced preoperative optimization and improved planning of operation pathways and timings may improve outcomes for patients. Colorectal Disease © 2017 The Association of Coloproctology of Great Britain and Ireland

Published
2018
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38. Additional file 4: of Perceived stress as a risk factor of unemployment: a register-based cohort study

Author

Mæhlisen, Maiken, Pasgaard, Alexander, Mortensen, Rikke, Vardinghus-Nielsen, Henrik, Torp-Pedersen, Christian, and Bøggild, Henrik

Abstract

Table S3. Hazard ratios (HR) and 95% confidence intervals (CI) of unemployment by perceived everyday life stress quintiles among men (N = 4567) and women (N = 4768). Unadjusted (model 1) and adjusted for age, education and income level (model 2). (DOCX 18 kb)

Published
2018
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41. Additional file 2: of Perceived stress as a risk factor of unemployment: a register-based cohort study

Author

Mæhlisen, Maiken, Pasgaard, Alexander, Mortensen, Rikke, Vardinghus-Nielsen, Henrik, Torp-Pedersen, Christian, and Bøggild, Henrik

Abstract

Table S2. Hazard ratios (HR) and 95% confidence intervals (CI) of unemployment by perceived everyday life stress quintiles. Unadjusted (model 1) and adjusted for gender, age, education level, income level, smoking, BMI, alcohol consumption and self-rated health (model 2). Complete cases (N = 8046). (DOCX 14 kb)

Published
2018
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42. Valve regurgitation in patients surviving endocarditis and the subsequent risk of heart failure

Author

Østergaard, Lauge, primary, Dahl, Anders, additional, Bruun, Niels Eske, additional, Oestergaard, Louise Bruun, additional, Lauridsen, Trine Kiilerich, additional, Torp-Pedersen, Christian, additional, Mortensen, Rikke, additional, Smerup, Morten, additional, Valeur, Nana, additional, Koeber, Lars, additional, Hassager, Christian, additional, Ihlemann, Nikolaj, additional, and Fosbøl, Emil Loldrup, additional

Published
2019
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43. The relationship between serum potassium concentrations and electrocardiographic characteristics in 163,547 individuals from primary care

Author

Krogager, Maria Lukács, primary, Kragholm, Kristian, additional, Skals, Regitze Kuhr, additional, Mortensen, Rikke Nørmark, additional, Polcwiartek, Christoffer, additional, Graff, Claus, additional, Nielsen, Jonas Bille, additional, Kanters, Jørgen K., additional, Holst, Anders Gaarsdal, additional, Søgaard, Peter, additional, Pietersen, Adrian, additional, Torp-Pedersen, Christian, additional, and Hansen, Steen Møller, additional

Published
2019
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44. Associations between common ECG abnormalities and out-of-hospital cardiac arrest

Author

Søndergaard, Marc Meller, primary, Nielsen, Jonas Bille, additional, Mortensen, Rikke Nørmark, additional, Gislason, Gunnar, additional, Køber, Lars, additional, Lippert, Freddy, additional, Graff, Claus, additional, Haunsø, Stig, additional, Svendsen, Jesper Hastrup, additional, Kragholm, Kristian Hay, additional, Pietersen, Adrian Holger, additional, Lind, Bent Struer, additional, Hjortshøj, Søren Pihlkjær, additional, Holst, Anders Gaarsdal, additional, Struijk, Johannes Jan, additional, Torp-Pedersen, Christian, additional, and Hansen, Steen Møller, additional

Published
2019
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46. Association between T-wave discordance and the development of heart failure in left bundle branch block patients: Results from the Copenhagen ECG study

Author

Jensen, Johannes Riis, primary, Kragholm, Kristian, additional, Bødker, Karoline Willum, additional, Mortensen, Rikke, additional, Graff, Claus, additional, Pietersen, Adrian, additional, Nielsen, Jonas Bille, additional, Polcwiartek, Christoffer, additional, Tayal, Bhupendar, additional, Torp-Pedersen, Christian, additional, Søgaard, Peter, additional, and Hansen, Steen Møller, additional

Published
2019
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47. Organ support therapy in the intensive care unit and return to work in out-of-hospital cardiac arrest survivors:A nationwide cohort study

Author

Riddersholm, Signe, Kragholm, Kristian, Mortensen, Rikke Nørmark, Hansen, Steen Moller, Wissenberg, Mads, Lippert, Freddy K, Torp-Pedersen, Christian, Christiansen, Christian F, Rasmussen, Bodil Steen, Riddersholm, Signe, Kragholm, Kristian, Mortensen, Rikke Nørmark, Hansen, Steen Moller, Wissenberg, Mads, Lippert, Freddy K, Torp-Pedersen, Christian, Christiansen, Christian F, and Rasmussen, Bodil Steen

Abstract

AIM: With increased survival after out-of-hospital cardiac arrest (OHCA), impact of the post-resuscitation course has become important. Among 30-day OHCA survivors, we investigated associations between organ support therapy in the Intensive Care Unit (ICU) and return to work.METHODS: This Danish nationwide cohort-study included 30-day-OHCA-survivors who were employed prior to arrest. We linked OHCA data to information on in-hospital care and return to work. For patients admitted to an ICU and based on renal replacement therapy (RRT), cardiovascular support and mechanical ventilation, we assessed the prognostic value of organ support therapies in multivariable Cox regression models.RESULTS: Of 1087 30-day survivors, 212 (19.5%) were treated in an ICU with 0-1 types of organ support, 494 (45.4%) with support of two organs, 26 (2.4%) with support of three organs and 355 (32.7%) were not admitted to an ICU. Return to work increased with decreasing number of organs supported, from 53.8% (95% CI: 49.5-70.1%) in patients treated with both RRT, cardiovascular support and mechanical ventilation to 88.5% (95% CI: 85.1-91.8%) in non-ICU-patients. In 732 ICU-patients, ICU-patients with support of 3 organs had significantly lower adjusted hazard ratios (HR) of returning to work (0.50 [95% CI: 0.30-0.85] compared to ICU-patients with support of 0-1 organ. The corresponding HR was 0.48 [95% CI: 0.30-0.78] for RRT alone.CONCLUSIONS: In 30-day survivors of OHCA, number of organ support therapies and in particular need of RRT were associated with reduced rate of return to work, although more than half of these latter patients still returned to work.

Published
2018

49. Work exposure and associated risk of hospitalisation with pneumonia and influenza: A nationwide study.

Author

Østergaard, Lauge, Mortensen, Rikke Nørmark, Kragholm, Kristian, Dalager-Pedersen, Michael, Koch, Kristoffer, Køber, Lars, Torp-Pedersen, Christian, and Fosbøl, Emil

Subjects
*RISK factors of pneumonia, *CONFIDENCE intervals, *REPORTING of diseases, *HOSPITAL care, *INFLUENZA, *MULTIVARIATE analysis, *NURSING care facilities, *OCCUPATIONS, *REGRESSION analysis, *RISK assessment, *SEWAGE, *TRANSPORTATION, *ADULT day care, *DISEASE incidence, *OCCUPATIONAL exposure, *DISEASE risk factors
Abstract

Background: Pneumonia and influenza are major health concerns and constitute a high economic burden. However, few data are available on the associated risk of pneumonia and influenza and work exposure on a large population scale. Aim: This study aimed to examine the associated risk of pneumonia and influenza by type of work exposure. Methods: By cross-linking administrative Danish registries, we classified people in 10 different profession types. The main outcome was hospitalisation with pneumonia or influenza. A multivariable Poisson regression analysis was used to assess the associated incidence rate ratio (IRR) of being hospitalised with pneumonia or influenza by type of profession. Results: A total of 1,327,606 people added risk time to the analyses. In a multivariable model, work in day care, public transportation, sewers and nursing home care was associated with an increased risk of hospitalisation with pneumonia compared to work within public administration: IRR=1.20 (95% confidence interval (CI) 1.12–1.28), IRR=1.21 (95% CI 1.09–1.34), IRR=1.61 (95% CI 1.19–2.19) and IRR=1.10 (95% CI 1.03–1.18), respectively. In a multivariable analysis, people working within public transportation were associated with an increased risk of hospitalisation with influenza compared to people working within public administration: IRR=2.54 (95% CI 1.79–3.58). Conclusions: Working in day care, public transportation, sewers and nursing home care increased the associated risk of hospitalisation with pneumonia, and working within public transportation increased the associated risk of being hospitalised with influenza compared to working within public administration. [ABSTRACT FROM AUTHOR]

Published
2021
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