127 results on '"Moruzzi, M C"'
Search Results
2. Imaging in gynecological disease (27): clinical and ultrasound characteristics of recurrent ovarian stromal cell tumors
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Moro, Francesca, Giudice, M. T., Bolomini, G., Moruzzi, M. C., Mascilini, F., Quagliozzi, L., Ciccarone, F., Scambia, Giovanni, Fagotti, Anna, Valentin, L., Testa, Antonia Carla, Moro, F., Scambia, G. (ORCID:0000-0003-2758-1063), Fagotti, A. (ORCID:0000-0001-5579-335X), Testa, A. C. (ORCID:0000-0003-2217-8726), Moro, Francesca, Giudice, M. T., Bolomini, G., Moruzzi, M. C., Mascilini, F., Quagliozzi, L., Ciccarone, F., Scambia, Giovanni, Fagotti, Anna, Valentin, L., Testa, Antonia Carla, Moro, F., Scambia, G. (ORCID:0000-0003-2758-1063), Fagotti, A. (ORCID:0000-0001-5579-335X), and Testa, A. C. (ORCID:0000-0003-2217-8726)
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Objective To describe the clinical and ultrasound characteristics of recurrent granulosa cell and Sertoli-Leydig cell tumors. Methods This was a retrospective observational study performed at Fondazione Policlinico Universitario A. Gemelli, Istituto di Ricovero e Cura a Carattere Scientifico, IRCCS, Rome (Gemelli center). Patients with a histological diagnosis of recurrent granulosa cell tumor or Sertoli-Leydig cell tumor were identified from the database of the Department of Gynecological Oncology. Those who had undergone a preoperative ultrasound examination at the Gemelli center between 2012 and 2020 were included, and the data retrieved from the original ultrasound reports. In all of these reports, the recurrent tumors were described using International Ovarian Tumor Analysis (IOTA) terminology. If a patient had more than one episode of relapse, information from all episodes was collected. If there was more than one recurrent tumor at the same ultrasound examination, all tumors were included. One expert sonographer also reviewed all available ultrasound images to identify typical ultrasound patterns using pattern recognition. Results We identified 30 patients with a histological diagnosis of recurrent granulosa cell tumor (25 patients, 55 tumors) or Sertoli-Leydig cell tumor (five patients, seven tumors). All 30 had undergone at least one preoperative ultrasound examination at the Gemelli center and were included. These women had a total of 66 episodes of relapse, of which a preoperative ultrasound examination had been performed at the Gemelli center in 34, revealing 62 recurrent lesions: one in 22/34 (64.7%) episodes of relapse, two in 4/34 (11.8%) episodes and three or more in 8/34 (23.5%) episodes. Most recurrent granulosa cell tumors (38/55, 69.1%) and recurrent Sertoli-Leydig tumors (6/7, 85.7%) were classified as solid or multilocular-solid tumors, while 8/55 (14.5%) recurrent granulosa cell tumors and 1/7 (14.3%) recurrent Sertoli-Leydig cell tumors were
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- 2024
3. Preliminary design of a short-medium range windowless aircraft
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Moruzzi, M. C. and Bagassi, S.
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- 2020
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4. Imaging in gynecological disease (27): clinical and ultrasound characteristics of recurrent ovarian stromal cell tumors.
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Moro, F., Giudice, M. T., Bolomini, G., Moruzzi, M. C., Mascilini, F., Quagliozzi, L., Ciccarone, F., Scambia, G., Fagotti, A., Valentin, L., and Testa, A. C.
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CELL tumors ,FEMALE reproductive organ diseases ,STROMAL cells ,ULTRASONIC imaging ,GRANULOSA cell tumors ,OVARIAN tumors - Abstract
Objective: To describe the clinical and ultrasound characteristics of recurrent granulosa cell and Sertoli–Leydig cell tumors. Methods: This was a retrospective observational study performed at Fondazione Policlinico Universitario A. Gemelli, Istituto di Ricovero e Cura a Carattere Scientifico, IRCCS, Rome (Gemelli center), Italy. Patients with a histological diagnosis of recurrent granulosa cell tumor or Sertoli–Leydig cell tumor were identified from the database of the Department of Gynecological Oncology. Those who had undergone a preoperative ultrasound examination at the Gemelli center between 2012 and 2020 were included, and the data retrieved from the original ultrasound reports. In all of these reports, the recurrent tumors were described using International Ovarian Tumor Analysis (IOTA) terminology. If a patient had more than one episode of relapse, information from all episodes was collected. If there was more than one recurrent tumor at the same ultrasound examination, all tumors were included. One expert sonographer also reviewed all available ultrasound images to identify typical ultrasound patterns using pattern recognition. Results: We identified 30 patients with a histological diagnosis of recurrent granulosa cell tumor (25 patients, 55 tumors) or Sertoli–Leydig cell tumor (five patients, seven tumors). All 30 had undergone at least one preoperative ultrasound examination at the Gemelli center and were included. These women had a total of 66 episodes of relapse, of which a preoperative ultrasound examination had been performed at the Gemelli center in 34, revealing 62 recurrent lesions: one in 22/34 (64.7%) episodes of relapse, two in 4/34 (11.8%) episodes and three or more in 8/34 (23.5%) episodes. Most recurrent granulosa cell tumors (38/55, 69.1%) and recurrent Sertoli–Leydig tumors (6/7, 85.7%) were classified as solid or multilocular‐solid tumors, while 8/55 (14.5%) recurrent granulosa cell tumors and 1/7 (14.3%) recurrent Sertoli–Leydig cell tumors were unilocular cysts and 9/55 (16.4%) recurrent granulosa cell tumors were multilocular cysts. The nine unilocular cysts had contents that were anechoic (n = 2) or had low‐level echogenicity (n = 7), had either smooth (n = 4) or irregular (n = 5) internal cyst walls, and ranged in largest diameter from 8 to 38 mm, with three being < 20 mm and five being 20–30 mm. On retrospective review of the images, two typical ultrasound patterns were described: small solid tumor measuring < 2 cm (15/62, 24.2%) and tumor with vascularized echogenic ground‐glass‐like content (12/62, 19.4%). Conclusions: Some granulosa cell and Sertoli–Leydig cell recurrences manifest one of two typical ultrasound patterns, while some appear as unilocular cysts. These are usually classified as benign, but in patients being followed up for a granulosa cell tumor or Sertoli–Leydig cell tumor, a unilocular cyst should be considered suspicious of recurrence. © 2023 The Authors. Ultrasound in Obstetrics & Gynecology published by John Wiley & Sons Ltd on behalf of International Society of Ultrasound in Obstetrics and Gynecology. [ABSTRACT FROM AUTHOR]
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- 2024
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5. Imaging in gynecological disease: clinical and ultrasound characteristics of recurrent ovarian stromal cell tumors
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Moro, F., primary, Giudice, M. T., additional, Bolomini, G., additional, Moruzzi, M. C., additional, Mascilini, F., additional, Quagliozzi, L., additional, Ciccarone, F., additional, Scambia, G., additional, Fagotti, A., additional, Valentin, L., additional, and Testa, A. C., additional
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- 2023
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6. TRANSVAGINAL/TRANSABDOMINAL SONOGRAPHY FOR HISTOLOGICAL DIAGNOSIS IN ADVANCED OVARIAN CANCER PATIENTS: A SINGLE INSTITUTION PROSPECTIVE STUDY: EP918
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Mascilini, F, Quagliozzi, L, Moruzzi, M C, Albanese, M, Testa, A C, Scambia, G, and Fagotti, A
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- 2019
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7. Imaging in gynecological disease (12): clinical and ultrasound features of invasive and non‐invasive malignant serous ovarian tumors
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Moro, F., Baima Poma, C., Zannoni, G. F., Vidal Urbinati, A., Pasciuto, T., Ludovisi, M., Moruzzi, M. C., Carinelli, S., Franchi, D., Scambia, G., and Testa, A. C.
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- 2017
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8. A non-invasive prevention program model for the assessment of osteoporosis in the early postmenopausal period: a pilot study on FRAX® and QUS tools advantages
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Villa, P., Lassandro, A. P., Moruzzi, M. C., Amar, I. D., Vacca, L., Di Nardo, F., De Waure, C., Pontecorvi, A., and Scambia, G.
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- 2016
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9. Diagnostic performance of ultrasound in assessing the extension of disease in advanced ovarian cancer
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Moruzzi, M. C., Bolomini, G., Esposito, R., Mascilini, F., Ciccarone, Francesca, Quagliozzi, L., Giudice, M. T., Beneduce, Giuliana, Ficarelli, S., Moroni, R., Scambia, Giovanni, Fagotti, Anna, Testa, Antonia Carla, Moro, Francesca, Ciccarone F., Beneduce G., Scambia G. (ORCID:0000-0003-2758-1063), Fagotti A. (ORCID:0000-0001-5579-335X), Testa A. C. (ORCID:0000-0003-2217-8726), Moro F., Moruzzi, M. C., Bolomini, G., Esposito, R., Mascilini, F., Ciccarone, Francesca, Quagliozzi, L., Giudice, M. T., Beneduce, Giuliana, Ficarelli, S., Moroni, R., Scambia, Giovanni, Fagotti, Anna, Testa, Antonia Carla, Moro, Francesca, Ciccarone F., Beneduce G., Scambia G. (ORCID:0000-0003-2758-1063), Fagotti A. (ORCID:0000-0001-5579-335X), Testa A. C. (ORCID:0000-0003-2217-8726), and Moro F.
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Background: Surgical exploration remains the gold standard for evaluating the extension of disease and predicting resectability. A laparoscopy-based scoring model was developed by Fagotti and colleagues in 2006 and updated in 2015, based on the intraoperative presence or absence of some specific cancer features. The model proved an overall accuracy rate of 77% to 100% and is considered the reference test for assessing resectability in our institution. Objective: The primary aim of the study was to analyze the agreement between preoperative ultrasound examination and laparoscopic findings in assessing the extension of intraabdominal disease using 6 parameters described by Fagotti's score. Study Design: This was a prospective single-center observational study. Between January 2019 and June 2020, consecutive patients with clinical or radiological suspicion of ovarian or peritoneal cancer were assessed with preoperative ultrasound examination and assigned a score based on the 6 Fagotti score parameters (great omentum, liver surface, lesser omentum/stomach/spleen, parietal peritoneum, diaphragms, bowel disease). Presence of mesenteral retraction of the small bowel and miliary carcinomatosis on the serosa were also evaluated. Each parameter was correlated with laparoscopic findings. Concordance was calculated between ultrasound and laparoscopic parameters using Cohen's kappa. Results: Cohen's kappa ranged from 0.70 to 0.90 for carcinomatosis on the small or large bowel, supracolic omentum, liver surface, and diaphragms. Cohen's kappa test was lower for carcinomatosis on the parietal peritoneum (k=0.63) and on the lesser omentum or lesser curvature of the stomach or spleen (k=0.54). The agreement between ultrasound and surgical predictive index value (score) was k=0.74. For the evaluation of mesenteral retraction and miliary carcinomatosis, the agreement was low (k=0.57 and k=0.36, respectively). Conclusion: The results of ultrasound and laparoscopy in the assessment of in
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- 2022
10. Fusion imaging in preoperative assessment of extent of disease in patients with advanced ovarian cancer: feasibility and agreement with laparoscopic findings
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Moro, F., primary, Bertoldo, V., additional, Avesani, G., additional, Moruzzi, M. C., additional, Mascilini, F., additional, Bolomini, G., additional, Caliolo, G., additional, Esposito, R., additional, Moroni, R., additional, Zannoni, G. F., additional, Fagotti, A., additional, Manfredi, R., additional, Scambia, G., additional, and Testa, A. C., additional
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- 2021
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11. OP07.07: Role of ultrasound in advanced ovarian cancer staging during pregnancy: a case report
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Moruzzi, M. C., primary, Esposito, R., additional, Beneduce, G., additional, Arciuolo, D., additional, Vegni, F., additional, Quagliozzi, L., additional, Biscione, A., additional, Bertoldo, V., additional, Landolfo, C., additional, and Testa, A.C., additional
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- 2021
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12. Repeat twisting of ovary in young woman with ribbon‐like contralateral ovary and absence of contralateral Fallopian tube
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Bolomini, G., primary, Moruzzi, M. C., additional, Moro, F., additional, Lavecchia, D., additional, Esposito, R., additional, Scambia, G., additional, and Testa, A. C., additional
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- 2021
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13. ATTENUATION OF NOISE IN THE CABIN OF A REGIONAL AIRCRAFT BY METAMATERIAL TRIM PANELS
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Moruzzi M. C., Cinefra M., Bagassi S., Carrera E., Moruzzi M.C., Cinefra M., Bagassi S., and Carrera E.
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Finite element method ,Metamaterial ,Vibroacoustic analysis ,Cabin comfort ,Noise reduction - Abstract
Interior noise has always been an issue for aircraft manufacturers, even if only recently has it received equal importance to other design requirements. Passengers are increasingly concerned about cabin comfort, which they consider high priority for medium and long flights. In order to reach the challenging interior noise target set for the new generation small aircraft 80 OASPL dB, 70 dBA, 56 dBSIL3, a noise reduction plan must address and accurately identify noise sources. The main goal of this work is to evaluate acoustic comfort, by analysing sound pressure levels, in the cabin of a regional turboprop subjected to multiple broadband noise components, that simulates the noise generated inside the aircraft with monopolar sources. Sandwiches with metamaterial core are employed as trim panels of the cabin for improving sound absorption through the fuselage and the averaged interior noise level at seated person ear height is numerically evaluated with the Finite Element commercial software, Actran®. In particular, this work aims to show the higher acoustic performances of innovative passive Noise & Vibration technologies, such as acoustic metamaterials, with respect to classical soundproofing solutions.
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- 2021
14. Repeat twisting of ovary in young woman with ribbon-like contralateral ovary and absence of contralateral Fallopian tube
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Bolomini, G., Moruzzi, M. C., Moro, Francesca, Lavecchia, D., Esposito, R., Scambia, Giovanni, Testa, Antonia Carla, Moro F., Scambia G. (ORCID:0000-0003-2758-1063), Testa A. C. (ORCID:0000-0003-2217-8726), Bolomini, G., Moruzzi, M. C., Moro, Francesca, Lavecchia, D., Esposito, R., Scambia, Giovanni, Testa, Antonia Carla, Moro F., Scambia G. (ORCID:0000-0003-2758-1063), and Testa A. C. (ORCID:0000-0003-2217-8726)
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To describe the clinical and ultrasound characteristics of three types of rare malignant ovarian germ cell tumor: embryonal carcinoma, non-gestational choriocarcinoma and malignant mixed germ cell tumor. This was a retrospective multicenter study. From the International Ovarian Tumor Analysis (IOTA) database, we identified patients with a histological diagnosis of ovarian embryonal carcinoma, non-gestational choriocarcinoma or malignant mixed germ cell tumor, who had undergone preoperative ultrasound examination by an experienced ultrasound examiner between 2000 and 2020. Additional patients with the same histology were identified from the databases of the departments of gynecological oncology in the participating centers. All tumors were described using IOTA terminology. Three examiners reviewed all available ultrasound images and described them using pattern recognition. One patient with embryonal carcinoma, five patients with non-gestational ovarian choriocarcinoma and seven patients with ovarian malignant mixed germ cell tumor (six primary tumors and one recurrence) were identified. Seven patients were included in the IOTA studies and six patients were examined outside of the IOTA studies. The median age at diagnosis was 26 (range, 14–77) years. Beta-human chorionic gonadotropin levels were highest in non-gestational choriocarcinomas and alpha-fetoprotein levels were highest in malignant mixed germ cell tumors. Most tumors were International Federation of Gynecology and Obstetrics (FIGO) Stage I (9/12 (75.0%)). All tumors were unilateral, and the median largest diameter was 129 (range, 38–216) mm. Of the tumors, 11/13 (84.6%) were solid and 2/13 (15.4%) were multilocular-solid; 9/13 (69.2%) manifested abundant vascularization on color Doppler examination. Using pattern recognition, the typical ultrasound appearance was a large solid tumor with inhomogeneous echogenicity of the solid tissue and often dispersed cysts which, in most cases, were small and irregular.
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- 2021
15. Fusion imaging in the preoperative assessment of the extension of disease in patients with advanced ovarian cancer: feasibility and agreement with laparoscopic findings
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Moro, Francesca, Bertoldo, V, Avesani, Giacomo, Moruzzi, M C, Mascilini, Floriana, Bolomini, G, Caliolo, Gianluca, Esposito, Raffaele, Moroni, R, Zannoni, Gian Franco, Fagotti, Anna, Manfredi, Riccardo, Scambia, Giovanni, Testa, Antonia Carla, Moro, F, Avesani, G, Mascilini, F, Caliolo, G, Esposito, R, Zannoni, G F (ORCID:0000-0003-1809-129X), Fagotti, A (ORCID:0000-0001-5579-335X), Manfredi, R (ORCID:0000-0002-4972-9500), Scambia, G (ORCID:0000-0003-2758-1063), Testa, A C (ORCID:0000-0003-2217-8726), Moro, Francesca, Bertoldo, V, Avesani, Giacomo, Moruzzi, M C, Mascilini, Floriana, Bolomini, G, Caliolo, Gianluca, Esposito, Raffaele, Moroni, R, Zannoni, Gian Franco, Fagotti, Anna, Manfredi, Riccardo, Scambia, Giovanni, Testa, Antonia Carla, Moro, F, Avesani, G, Mascilini, F, Caliolo, G, Esposito, R, Zannoni, G F (ORCID:0000-0003-1809-129X), Fagotti, A (ORCID:0000-0001-5579-335X), Manfredi, R (ORCID:0000-0002-4972-9500), Scambia, G (ORCID:0000-0003-2758-1063), and Testa, A C (ORCID:0000-0003-2217-8726)
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Objectives: Fusion imaging is an emerging technique that can fuse real time ultrasound examination with other imaging modalities such as computed tomography (CT), magnetic resonance, and positron emission tomography. The primary aim of the study was to evaluate the Fusion imaging feasibility in patients with advanced ovarian cancer. The secondary aims were: 1) to compare agreement laparoscopic findings with Fusion, CT scan alone and ultrasound alone in assessing the extension of intra-abdominal disease; 2) to evaluate the time required by the Fusion technique. Methods: patients with clinical and/or radiographic suspicion of advanced ovarian or peritoneal cancer and candidate to surgery were prospectively enrolled between December 2019 and September 2020. All patients underwent CT scan, ultrasound and Fusion examination in order to evaluate the presence/absence of the following abdominal cancer features according to the laparoscopy-based scoring model (PIV: Predictive Index Value): supracolic omentum disease, visceral carcinomatosis on the liver, lesser omental carcinomatosis and/or visceral carcinomatosis on the lesser curvature of stomach and/or on the spleen, parietal peritoneal involvement of paracolic gutter/-s and/or anterior abdominal wall, parietal peritoneal involvement of diaphragm and visceral carcinomatosis on small and large bowel (except rectosigmoid). Feasibility of the Fusion examination was evaluated. Agreement between each imaging method (ultrasound, CT scan and Fusion) and laparoscopy (considered as reference standard) was calculated using Cohen's kappa coefficient. Results: 52 patients were enrolled in the study. Fusion examination was feasible in 51/52 (98%) patients (in one patient the CD was not working). Two other patients were excluded because laparoscopy was not performed. 49 women were considered for final analysis. Kappa values between CT, ultrasound, Fusion and laparoscopy in assessing the PIV parameters were respectively: 0.781, 0.845 an
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- 2021
16. Ultrasound features of appendiceal adenoneuroendocrine carcinoma metastatic to ovaries
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Codecà, C., primary, Moruzzi, M. C., additional, Spina, M. R., additional, Moro, F., additional, Scambia, G., additional, and Testa, A. C., additional
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- 2021
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17. Ultrasound features of ovarian recurrence of medullary thyroid carcinoma
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Codecà, C., primary, Moruzzi, M. C., additional, Paris, V., additional, Moro, F., additional, Scambia, G., additional, and Testa, A. C., additional
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- 2021
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18. How to perform lung ultrasound in pregnant women with suspected COVID-19
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Moro, Francesca, Buonsenso, Danilo, Moruzzi, M. C., Inchingolo, Riccardo, Smargiassi, Andrea, Demi, L., Larici, Anna Rita, Scambia, Giovanni, Lanzone, Antonio, Testa, Antonia Carla, Moro F., Buonsenso D., Inchingolo R. (ORCID:0000-0003-2843-9966), Smargiassi A., Larici A. R. (ORCID:0000-0002-1882-6244), Scambia G. (ORCID:0000-0003-2758-1063), Lanzone A. (ORCID:0000-0003-4119-414X), Testa A. C. (ORCID:0000-0003-2217-8726), Moro, Francesca, Buonsenso, Danilo, Moruzzi, M. C., Inchingolo, Riccardo, Smargiassi, Andrea, Demi, L., Larici, Anna Rita, Scambia, Giovanni, Lanzone, Antonio, Testa, Antonia Carla, Moro F., Buonsenso D., Inchingolo R. (ORCID:0000-0003-2843-9966), Smargiassi A., Larici A. R. (ORCID:0000-0002-1882-6244), Scambia G. (ORCID:0000-0003-2758-1063), Lanzone A. (ORCID:0000-0003-4119-414X), and Testa A. C. (ORCID:0000-0003-2217-8726)
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Under certain circumstances, such as during the current COVID-19 outbreak, pregnant women can be a target for respiratory infection, and lung examination may be required as part of their clinical evaluation, ideally while avoiding exposure to radiation. We propose a practical approach for obstetricians/gynecologists to perform lung ultrasound examination, discussing potential applications, semiology and practical aspects, which could be of particular importance in emergency situations, such as the current pandemic infection of COVID-19. Copyright © 2020 ISUOG. Published by John Wiley & Sons Ltd.
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- 2020
19. Minimal residual disease at primary debulking surgery versus complete tumor resection at interval debulking surgery in advanced epithelial ovarian cancer: A survival analysis
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Ghirardi, V., Moruzzi, M. C., Bizzarri, N., Vargiu, V., D'Indinosante, Marco, Garganese, Giorgia, Pasciuto, Tina, Loverro, Matteo, Scambia, Giovanni, Fagotti, Anna, D'Indinosante M., Garganese G. (ORCID:0000-0002-4209-5285), Pasciuto T. (ORCID:0000-0003-2959-8571), Loverro M., Scambia G. (ORCID:0000-0003-2758-1063), Fagotti A. (ORCID:0000-0001-5579-335X), Ghirardi, V., Moruzzi, M. C., Bizzarri, N., Vargiu, V., D'Indinosante, Marco, Garganese, Giorgia, Pasciuto, Tina, Loverro, Matteo, Scambia, Giovanni, Fagotti, Anna, D'Indinosante M., Garganese G. (ORCID:0000-0002-4209-5285), Pasciuto T. (ORCID:0000-0003-2959-8571), Loverro M., Scambia G. (ORCID:0000-0003-2758-1063), and Fagotti A. (ORCID:0000-0001-5579-335X)
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Objectives: To compare survival outcomes and peri-operative complications in patients with advanced ovarian cancer with 1–10 mm residual disease (RD) at primary debulking surgery (PDS) versus those achieving no gross residual disease (NGR) at interval debulking surgery (IDS). Methods: Patients operated with the intent of complete cytoreduction for epithelial ovarian/fallopian tube/primary peritoneal cancer, FIGO stage IIIC-IV, RD 1–10 mm at PDS and NGR at IDS, between 01/2010 and 12/2016, were retrospectively included. All patients had at least 2-years of follow-up completed. Results: 207 patients were included (59 PDS and 148 IDS). Patients in PDS group were younger and had a higher surgical complexity score. There was a higher rate of intra- and major early post-operative complications in the group of PDS vs IDS (16.9% vs 1.3% and 28.8% vs 2.0%, p < 0.0001 respectively). After a median follow up of 56.4 months (range 59.2–65.4), 117 (56.5%) patients died of disease in the whole population. Forty-eight (81.4%) patients had progression/recurrent disease in the PDS group and 120 (81.1%) in the IDS group. Median PFS was 16.2 months and 18.9 months for PDS and IDS group, respectively (p = 0.111). Median OS was 41.4 months and 52.4 months for PDS and IDS group, respectively (p = 0.022). Conclusions: IDS should be considered the preferred treatment in case millimetric residual disease is expected at PDS in view of the superimposable PFS and the reduced number of perioperative complications.
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- 2020
20. Diagnostic performance of ultrasound in assessing the extension of the disease in patients with suspicion of malignant ovarian tumor: Correlation between ultrasound parameters and Fagotti's score
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Moruzzi, M. C., Bolomini, G., Moro, Francesca, Mascilini, Floriana, Ficarelli, S., Beneduce, G., Giudice, Maria Teresa, Pasciuto, Tina, Moroni, R., Scambia, Giovanni, Fagotti, Anna, Testa, Antonia Carla, Moro F., Mascilini F., Giudice M. T., Pasciuto T. (ORCID:0000-0003-2959-8571), Scambia G. (ORCID:0000-0003-2758-1063), Fagotti A. (ORCID:0000-0001-5579-335X), Testa A. C. (ORCID:0000-0003-2217-8726), Moruzzi, M. C., Bolomini, G., Moro, Francesca, Mascilini, Floriana, Ficarelli, S., Beneduce, G., Giudice, Maria Teresa, Pasciuto, Tina, Moroni, R., Scambia, Giovanni, Fagotti, Anna, Testa, Antonia Carla, Moro F., Mascilini F., Giudice M. T., Pasciuto T. (ORCID:0000-0003-2959-8571), Scambia G. (ORCID:0000-0003-2758-1063), Fagotti A. (ORCID:0000-0001-5579-335X), and Testa A. C. (ORCID:0000-0003-2217-8726)
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Background: A radical surgical approach represents the mainstay treatment for gynecological malignancy, and preoperative staging of ovarian cancer is crucial. Ultrasound evaluation is widely recognized as the gold standard technique for the characterization of ovarian masses due to a high sensitivity for malignancy. In addition, its accuracy in defining intra-abdominal ovarian cancer spread has been previously proposed. Primary objective: To analyze the agreement between preoperative ultrasound examination and laparoscopic findings in assessing the extension of intra-abdominal disease using six parameters as described by Fagotti's score. Study hypothesis: When performed by expert examiners, ultrasound can be an accurate technique to assess tumor spread in ovarian cancer and therefore to predict surgical resectability. Trial design: This is a single-center prospective observational study. Patients with clinical and/or radiological suspicion of advanced ovarian or peritoneal cancer will be assessed with preoperative ultrasound and assigned a score based on the six Fagotti's laparoscopic score parameters. Each parameter will then be correlated with laparoscopic findings. Major inclusion/exclusion criteria: Eligible patients include women 18-75 years of age with clinical and/or imaging suggestive of advanced ovarian or peritoneal cancer, and an ECOG performance status 0-3. Primary endpoints: Sensitivity and specificity of ultrasound in detecting carcinomatosis, using the parameters of Fagotti's score as a reference standard. Agreement between preoperative ultrasound examination and laparoscopic findings in assessing the extension of intra-abdominal disease as described in Fagotti's score. Sample size: 240 patients. Estimate dates for completing accrual and presenting results: The accrual started in January 2019. Enrollment should be completed approximately by October 2020 and the results will be analyzed by December 2020. Trial registration: The study received the Ethic
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- 2020
21. Management of ovarian masses in pregnancy: Patient selection for interventional treatment
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Testa, Antonia Carla, Mascilini, Floriana, Quagliozzi, L., Moro, Francesca, Bolomini, G., Mirandola, M. T., Moruzzi, M. C., Scambia, Giovanni, Fagotti, Anna, Testa A. C. (ORCID:0000-0003-2217-8726), Mascilini F., Moro F., Scambia G. (ORCID:0000-0003-2758-1063), Fagotti A. (ORCID:0000-0001-5579-335X), Testa, Antonia Carla, Mascilini, Floriana, Quagliozzi, L., Moro, Francesca, Bolomini, G., Mirandola, M. T., Moruzzi, M. C., Scambia, Giovanni, Fagotti, Anna, Testa A. C. (ORCID:0000-0003-2217-8726), Mascilini F., Moro F., Scambia G. (ORCID:0000-0003-2758-1063), and Fagotti A. (ORCID:0000-0001-5579-335X)
- Abstract
Objective: The management of pregnant women with an adnexal tumor is still challenging and in the literature few data are available. The aim of this study was to describe the management and outcome of patients with ovarian masses detected during pregnancy. As secondary aims, we evaluated the prevalence of malignancy in the International Ovarian Tumor Analysis (IOTA) morphological classes of ovarian masses diagnosed during pregnancy, and created an algorithm for the management of patients with adnexal masses during pregnancy. Methods: This was a retrospective single centered study including patients with adnexal masses detected at any trimester during pregnancy between January 2000 and December 2019. Clinical, ultrasound, surgical, and histological data were retrieved from medical records as well as information on management (ultrasound follow-up vs surgery). Indications for surgery were recorded in terms of suspicion of malignancy based on pattern recognition of the ultrasound examiner or on symptoms or prevention of complications, such as torsion, rupture, or obstacle to normal full-term pregnancy. All masses were described using IOTA terminology. Results: A total of 113 patients were selected for the analysis. Of these, 48 (42%) patients had surveillance and 65 (58%) patients underwent surgery (11 primary ovarian tumors, one recurrence of ovarian cancer, four metastases to the ovary, 20 borderline tumors, and 29 benign lesions). Indications for surgery were suspicious malignancy in 41/65 (63.1%) cases and symptoms or prevention of complications in 24/65 (36.9%) cases. All patients in the surveillance group showed no morphological changes of the ovarian lesions at 6 months after delivery. According to the IOTA ultrasound morphological category, the prevalence of malignancy was 0% (0/37) in the unilocular cyst group, 27% (4/15) in the multilocular group, 35% (11/31) in the unilocular solid group, 70% (14/20) in the multilocular solid group, and 70% (7/10) in the sol
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- 2020
22. Role of transvaginal ultrasound-guided biopsy in gynecology
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Mascilini, Floriana, Quagliozzi, L., Moro, Francesca, Moruzzi, M. C., De Blasis, I., Paris, V., Scambia, Giovanni, Fagotti, Anna, Testa, Antonia Carla, Mascilini F., Moro F., Scambia G. (ORCID:0000-0003-2758-1063), Fagotti A. (ORCID:0000-0001-5579-335X), Testa A. C. (ORCID:0000-0003-2217-8726), Mascilini, Floriana, Quagliozzi, L., Moro, Francesca, Moruzzi, M. C., De Blasis, I., Paris, V., Scambia, Giovanni, Fagotti, Anna, Testa, Antonia Carla, Mascilini F., Moro F., Scambia G. (ORCID:0000-0003-2758-1063), Fagotti A. (ORCID:0000-0001-5579-335X), and Testa A. C. (ORCID:0000-0003-2217-8726)
- Abstract
Background Ultrasound-guided biopsy is an easy technique for obtaining tissue samples. It is commonly used for different types of tumors, such as breast and prostate cancers, in order to plan early and adequate treatment. Objective To evaluate the indications, adequacy, and safety of transvaginal ultrasound-guided biopsy in women with pelvic lesions suspected of gynecologic malignancy. Methods A retrospective study including all patients who had undergone transvaginal ultrasound-guided biopsy between April 2015 and May 2018 was carried out at the division of gynecologic oncology. Inclusion criteria were the presence at imaging of abdominal or pelvic tumors in patients considered not ideal candidates for primary gynecological surgery, or the origin and/or nature of the tumor was unclear and further management required histological verification. Patients with planned surgery were excluded from the study. Transvaginal biopsies were performed with a 18 G/25 cm core-cut biopsy needle and histology was obtained. Tru-cut biopsies were performed using an automatic bioptic gun with a 18 G/25 cm core-cut biopsy needle. Results are presented as absolute frequency (percentage) for nominal variables and as median (range) for continuous variables. Results A total of 62 women were analyzed. An adequate sample for histological analysis was obtained in all cases. Histopathological examinations showed 24 (38.7%) benign lesions (fibrosis, inflammation, uterine or ovarian myoma) and 38 (61.3%) malignant tumors, distributed as follows: 34 (89.5%) malignant gynecological lesions and 4 (10.5%) non-gynecological malignant tumors. Among the malignant lesions, there were 12/38 (31.6%) primary tumors, 24/38 (63.2%) recurrent tumors, and 2/38 (5.3%) metastases from non-genital cancer. Ten patients eventually underwent surgery. Final histology was not in agreement with the results from transvaginal ultrasound-guided biopsy in 2 of 10 patients (20%); in particular, benign disease at transvaginal
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- 2020
23. Imaging in gynecological disease (8): ultrasound characteristics of recurrent borderline ovarian tumors
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FRANCHI, D., BOVERI, S., FRUSCIO, R., FISCHEROVA, D., GUERRIERO, S., MORUZZI, M. C., COLOMBO, N., TIMMERMAN, D., VALENTIN, L., and TESTA, A. C.
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- 2013
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24. Additively manufactured negative stiffness structures for shock absorber applications.
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Corsi, M., Bagassi, S., Moruzzi, M. C., and Weigand, F.
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SHOCK absorbers ,SELECTIVE laser sintering ,FUNCTIONAL integration ,MECHANICAL buckling ,MATERIALS compression testing ,FLEXIBLE structures - Abstract
Negative stiffness structures (NSS), as a branch of multi-stable mechanical metamaterials, exhibit multiple stable configurations. Their characteristics, such as bistability, snap-through and negative stiffness, make them particularly suitable for shock absorber applications. The majority of NSS is designed in a cuboidal shape and only recently few studies focused on cylindrical NSS. Lately, Fraunhofer for Additive Manufacturing Technologies IAPT, has started some studies to optimize these structures and to profit by their features in different applications, such as InspectionCopter project. During this study, three types of special-shaped NSS were designed, produced and tested. To determine the influence of dimensional parameters and materials on the functionality of these flexible structures, for each one of three concepts, five different versions in two different materials and techniques were realized. The specimens were fabricated in PEBA (PolyEther Block Amide) and TPU (Thermoplastic PolyUrethane) using, respectively, Selective Laser Sintering (SLS) and MultiJet Printing (MJP) technologies; the design freedom of Additive Manufacturing (AM) allows the production of complex structures and the possibility of functional integration, such as shock absorber functionality. To investigate the mechanical and NS properties of these structures and their deformation mechanisms, quasi-static compression tests were performed according to ASTM D695 − 15 regulation. The results, analyzed through force–displacement curves, highlighted the energy recovery of the specimens during deformation and the influence of dimensional parameters on the response to the applied loads. During the tests, it was also evident how the usage of different dimensions and materials can lead, for the same structure, to a symmetric or asymmetric buckling mode in the collapse of the layers and to prevent the structure from returning to its original shape once the load has been removed. [ABSTRACT FROM AUTHOR]
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- 2022
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- View/download PDF
25. Additively manufactured negative stiffness structures for shock absorber applications
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Corsi, M., primary, Bagassi, S., additional, Moruzzi, M. C., additional, and Weigand, F., additional
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- 2020
- Full Text
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26. Intraoperative ultrasound assistance during myomectomy in pregnant woman
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Moruzzi, M. C., primary, Moro, F., additional, Bolomini, G., additional, Macchi, C., additional, Cavaliere, A. F., additional, Fagotti, A., additional, Scambia, G., additional, and Testa, A. C., additional
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- 2020
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- View/download PDF
27. How to perform lung ultrasound in pregnant women with suspected COVID‐19
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Moro, F., primary, Buonsenso, D., additional, Moruzzi, M. C., additional, Inchingolo, R., additional, Smargiassi, A., additional, Demi, L., additional, Larici, A. R., additional, Scambia, G., additional, Lanzone, A., additional, and Testa, A. C., additional
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- 2020
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28. Vibroacoustic analysis of an innovative windowless cabin with metamaterial trim panels in regional turboprops
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Moruzzi, M. C., primary, Cinefra, M., additional, and Bagassi, S., additional
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- 2019
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29. Imaging of gynecological disease: clinical and ultrasound characteristics of uterine sarcomas
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Ludovisi, Manuela, Moro, Francesca, Pasciuto, Tina, Di Noi, Silvia, Giunchi, S, Savelli, L, Pascual, M A, Sladkevicius, P, Alcazar, J L, Franchi, D, Mancari, R, Moruzzi, M C, Jurkovic, D, Chiappa, V, Guerriero, S, Exacoustos, C, Epstein, E, Frühauf, P, Fischerova, D, Fruscio, R, Ciccarone, F, Zannoni, Gian Franco, Scambia, Giovanni, Valentin, L, and Testa, Antonia Carla
- Subjects
endometrial stromal ,leiomyosarcoma ,pattern recognition ,sarcoma ,ultrasonography ,Settore MED/40 - GINECOLOGIA E OSTETRICIA - Published
- 2019
30. Imaging in gynecological disease (15): clinical and ultrasound characteristics of uterine sarcoma
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Ludovisi, M, Moro, F, Pasciuto, T, Di Noi, S, Giunchi, S, Savelli, L, Pascual, M, Sladkevicius, P, Alcazar, J, Franchi, D, Mancari, R, Moruzzi, M, Jurkovic, D, Chiappa, V, Guerriero, S, Exacoustos, C, Epstein, E, Frühauf, P, Fischerova, D, Fruscio, R, Ciccarone, F, Zannoni, G, Scambia, G, Valentin, L, Testa, A, Pascual, M A, Alcazar, J L, Moruzzi, M C, Zannoni, G F, Testa, A C, Ludovisi, M, Moro, F, Pasciuto, T, Di Noi, S, Giunchi, S, Savelli, L, Pascual, M, Sladkevicius, P, Alcazar, J, Franchi, D, Mancari, R, Moruzzi, M, Jurkovic, D, Chiappa, V, Guerriero, S, Exacoustos, C, Epstein, E, Frühauf, P, Fischerova, D, Fruscio, R, Ciccarone, F, Zannoni, G, Scambia, G, Valentin, L, Testa, A, Pascual, M A, Alcazar, J L, Moruzzi, M C, Zannoni, G F, and Testa, A C
- Abstract
Objective: To describe the clinical and ultrasound characteristics of uterine sarcomas. Methods: This was a retrospective multicenter study. From the databases of 13 ultrasound centers, we identified patients with a histological diagnosis of uterine sarcoma with available ultrasound reports and ultrasound images who had undergone preoperative ultrasound examination between 1996 and 2016. As the first step, each author collected information from the original ultrasound reports from his/her own center on predefined ultrasound features of the tumors and by reviewing the ultrasound images to identify information on variables not described in the original report. As the second step, 16 ultrasound examiners reviewed the images electronically in a consensus meeting and described them using predetermined terminology. Results: We identified 116 patients with leiomyosarcoma, 48 with endometrial stromal sarcoma and 31 with undifferentiated endometrial sarcoma. Median age of the patients was 56 years (range, 26–86 years). Most patients were symptomatic at diagnosis (164/183 (89.6%)), the most frequent presenting symptom being abnormal vaginal bleeding (91/183 (49.7%)). Patients with endometrial stromal sarcoma were younger than those with leiomyosarcoma and undifferentiated endometrial sarcoma (median age, 46 years vs 57 and 60 years, respectively). According to the assessment by the original ultrasound examiners, the median diameter of the largest tumor was 91 mm (range, 7–321 mm). Visible normal myometrium was reported in 149/195 (76.4%) cases, and 80.0% (156/195) of lesions were solitary. Most sarcomas (155/195 (79.5%)) were solid masses (> 80% solid tissue), and most manifested inhomogeneous echogenicity of the solid tissue (151/195 (77.4%)); one sarcoma was multilocular without solid components. Cystic areas were described in 87/195 (44.6%) tumors and most cyst cavities had irregular walls (67/87 (77.0%)). Internal shadowing was observed in 42/192 (21.9%) sarcomas and fan
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- 2019
31. Role of CA125/CEA ratio and ultrasound parameters in identifying metastases to the ovaries in patients with multilocular and multilocular-solid ovarian masses
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Moro, Francesca, Pasciuto, Tina, Djokovic, D., Di Legge, A., Granato, V., Moruzzi, M. C., Mancari, R., Zannoni, Gian Franco, Fischerova, D., Franchi, D., Scambia, Giovanni, Testa, Antonia Carla, Moro, F., Pasciuto, T. (ORCID:0000-0003-2959-8571), Zannoni, G. F. (ORCID:0000-0003-1809-129X), Scambia, G. (ORCID:0000-0003-2758-1063), Testa, A. C. (ORCID:0000-0003-2217-8726), Moro, Francesca, Pasciuto, Tina, Djokovic, D., Di Legge, A., Granato, V., Moruzzi, M. C., Mancari, R., Zannoni, Gian Franco, Fischerova, D., Franchi, D., Scambia, Giovanni, Testa, Antonia Carla, Moro, F., Pasciuto, T. (ORCID:0000-0003-2959-8571), Zannoni, G. F. (ORCID:0000-0003-1809-129X), Scambia, G. (ORCID:0000-0003-2758-1063), and Testa, A. C. (ORCID:0000-0003-2217-8726)
- Abstract
Objectives: To investigate ultrasound features and the best cut-off value of the cancer antigen 125/carcinoembryonic antigen (CA125/CEA) ratio to discriminate ovarian metastases from benign and primary malignant ovarian neoplasms in two selected groups of morphological ovarian masses, namely multilocular masses with five or more locules and multilocular-solid masses. Methods: Patients with multilocular (five or more locules) or multilocular-solid ovarian masses, operated on within 3 months of ultrasound examination, and with tumor markers (CEA and CA125) available at diagnosis, were identified retrospectively from three ultrasound centers. The masses were described using the International Ovarian Tumor Analysis (IOTA) terminology. Ultrasound and clinical characteristics were compared between those with an ovarian neoplasm (including benign and primary malignant neoplasms) and those with an ovarian metastasis. Receiver–operating characteristics curve (ROC) analysis was used to evaluate the ability of CA125, CEA and CA125/CEA to differentiate between ovarian neoplasms and ovarian metastases, and their predictive performance was assessed. Results: In total, 350 (88.4%) patients with an ovarian neoplasm (including 99 benign, 43 borderline and 197 primary epithelial ovarian carcinomas, seven malignant rare tumors and four other types of invasive ovarian tumor) and 46 (11.6%) patients with an ovarian metastasis were analyzed. On ultrasound examination, ovarian neoplasms were smaller than ovarian metastases (median largest diameter, 97 (range, 20–387) mm vs 146 (range, 43–259) mm, respectively; P < 0.0001) and presented with a lower number of cysts with > 10 locules (18.9% vs 54.3%; P < 0.0001). ROC curve analysis showed that the best cut-off value of CEA for distinguishing between ovarian neoplasms and ovarian metastases was 2.33 ng/mL. The predictive performance of this CEA cut-off value was: area under the curve (AUC), 0.791 (95% CI, 0.711–0.870); accuracy, 73.
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- 2019
32. Vibroacoustic analysis of an innovative windowless cabin with metamaterial trim panels in regional turboprops.
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Moruzzi, M. C., Cinefra, M., and Bagassi, S.
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- *
ACOUSTIC vibrations , *NOISE control , *SOUND pressure , *VACATION homes , *MODEL airplanes - Abstract
The purpose of this work is to study the possible noise reduction, in terms of sound pressure level, in the passenger cabin of a regional turboprop aircraft under multiple tonal and broadband noise components characterizing the noise generated by the engines during cruise flight conditions. In particular, we want to show the acoustic performances of innovative passive noise and vibration technologies, such as acoustic metamaterials applied to the trim panel of the cabin, in the low-frequency range, from 100 to 300 Hz. Moreover, the removal of windows from the passenger cabin is evaluated, in acoustic terms. Analyses are performed using a numerical tool, Actran, a finite element based software, and a numerical model of a regional aircraft fuselage. According to the results, metamaterials seem to have significant acoustic performances that lead to a reduction in noise and therefore an increase in passenger comfort. [ABSTRACT FROM AUTHOR]
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- 2021
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33. Preliminary design of a long range windowless aircraft concept
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Bagassi, S., Lucchi, F., Moruzzi, M. C., Bagassi, S., Lucchi, F., and Moruzzi, M.C.
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Control and Systems Engineering ,Windowless configuration ,Aircraft preliminary design ,Weight reduction ,Aerospace Engineering ,ComputerApplications_COMPUTERSINOTHERSYSTEMS ,Materials Science (all) ,Electrical and Electronic Engineering ,Fuselage design - Abstract
The objective of this paper is to describe the preliminary design of a windowless configuration of a long-range aircraft and to analytically assess the achieved weight reduction. As a matter of fact, the reduction of weight is directly linked with reduction of fuel consumption; consequently there are advantages in terms of aircraft operative costs and emissions of carbon dioxide. A feasibility study will bring to the assessment of weight and cost reduction in consideration to the introduction of innovative screens, to give passengers the possibility to see through the fuselage itself. The proposed methodology consists in the preliminary design of a long-range aircraft, considering some defined design parameters and constraints. The activity will finally lead to weight reduction evaluation, in case the same aircraft will be designed windowless. In the end the methodology is applied to two existing aircrafts to estimate potential benefits of the windowless configuration if compared to the traditional one: the Airbus 340-500 and the Being 777-300.
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- 2018
34. Imaging in gynecological disease (15): clinical and ultrasound characteristics of uterine sarcoma
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Ludovisi, M., primary, Moro, F., additional, Pasciuto, T., additional, Di Noi, S., additional, Giunchi, S., additional, Savelli, L., additional, Pascual, M. A., additional, Sladkevicius, P., additional, Alcazar, J. L., additional, Franchi, D., additional, Mancari, R., additional, Moruzzi, M. C., additional, Jurkovic, D., additional, Chiappa, V., additional, Guerriero, S., additional, Exacoustos, C., additional, Epstein, E., additional, Frühauf, F., additional, Fischerova, D., additional, Fruscio, R., additional, Ciccarone, F., additional, Zannoni, G. F., additional, Scambia, G., additional, Valentin, L., additional, and Testa, A. C., additional
- Published
- 2019
- Full Text
- View/download PDF
35. Role of CA125/CEA ratio and ultrasound parameters in identifying metastases to the ovaries in patients with multilocular and multilocular‐solid ovarian masses
- Author
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Moro, F., primary, Pasciuto, T., additional, Djokovic, D., additional, Di Legge, A., additional, Granato, V., additional, Moruzzi, M. C., additional, Mancari, R., additional, Zannoni, G. F., additional, Fischerova, D., additional, Franchi, D., additional, Scambia, G., additional, and Testa, A. C., additional
- Published
- 2019
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36. PRospective Imaging of CErvical cancer and neoadjuvant treatment (PRICE) study: role of ultrasound to predict partial response in locally advanced cervical cancer patients undergoing chemoradiation and radical surgery
- Author
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Testa, A. C. (ORCID:0000-0003-2217-8726), Ferrandina, G. (ORCID:0000-0003-4672-4197), Moro, F., Pasciuto, T., Moruzzi, M. C., De Blasis, I., Mascilini, F., Foti, E., Autorino, R., Collarino, A., Gui, B., Zannoni, G. F. (ORCID:0000-0003-1809-129X), Gambacorta, M. A. (ORCID:0000-0001-5455-8737), Valentini, A. L. (ORCID:0000-0001-6746-692X), Rufini, V. (ORCID:0000-0002-2052-8078), Scambia, G. (ORCID:0000-0003-2758-1063), Testa, A. C. (ORCID:0000-0003-2217-8726), Ferrandina, G. (ORCID:0000-0003-4672-4197), Moro, F., Pasciuto, T., Moruzzi, M. C., De Blasis, I., Mascilini, F., Foti, E., Autorino, R., Collarino, A., Gui, B., Zannoni, G. F. (ORCID:0000-0003-1809-129X), Gambacorta, M. A. (ORCID:0000-0001-5455-8737), Valentini, A. L. (ORCID:0000-0001-6746-692X), Rufini, V. (ORCID:0000-0002-2052-8078), and Scambia, G. (ORCID:0000-0003-2758-1063)
- Abstract
Objective: Chemoradiation-based neoadjuvant treatment followed by radical surgery is an alternative therapeutic strategy for locally advanced cervical cancer (LACC), but ultrasound variables used to predict partial response to neoadjuvant treatment are not well defined. Our goal was to analyze prospectively the potential role of transvaginal ultrasound in early prediction of partial pathological response, assessed in terms of residual disease at histology, in a large, single-institution series of LACC patients triaged to neoadjuvant treatment followed by radical surgery. Methods: Between October 2010 and June 2014, we screened 108 women with histologically documented LACC Stage IB2–IVA, of whom 88 were included in the final analysis. Tumor volume, three-dimensional (3D) power Doppler indices and contrast parameters were obtained before (baseline examination) and after 2 weeks of treatment. The pathological response was defined as complete (absence of any residual tumor after treatment) or partial (microscopic and/or macroscopic residual tumor at pathological examination). Complete-response and partial-response groups were compared and receiver–operating characteristics (ROC) curves were generated for ultrasound variables that were statistically significant on univariate analysis to evaluate their diagnostic ability to predict partial pathological response. Results: There was a complete pathological response to neoadjuvant therapy in 40 (45.5%) patients and a partial response in 48 (54.5%). At baseline examination, tumor volume did not differ between the two groups. However, after 2 weeks of neoadjuvant treatment, the tumor volume was significantly greater in patients with partial response than it was in those with complete response (P = 0.019). Among the 3D vascular indices, the vascularization index (VI) was significantly lower in the partial-response compared with the complete-response group, both before and after 2 weeks of treatment (P = 0.037 and P = 0.024, res
- Published
- 2018
37. PRospective Imaging of CErvical cancer and neoadjuvant treatment (PRICE) study: role of ultrasound to predict partial response in locally advanced cervical cancer patients undergoing chemoradiation and radical surgery
- Author
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Testa, Antonia Carla, Ferrandina, Maria Gabriella, Moro, F., Pasciuto, Tina, Moruzzi, M. C., De Blasis, I., Mascilini, Floriana, Foti, E., Autorino, R., Collarino, A., Gui, B., Zannoni, Gian Franco, Gambacorta, Maria Antonietta, Valentini, A. L., Rufini, Vittoria, Scambia, Giovanni, Testa A. C. (ORCID:0000-0003-2217-8726), Ferrandina G. (ORCID:0000-0003-4672-4197), Pasciuto T. (ORCID:0000-0003-2959-8571), Mascilini F., Zannoni G. F. (ORCID:0000-0003-1809-129X), Gambacorta M. A. (ORCID:0000-0001-5455-8737), Rufini V. (ORCID:0000-0002-2052-8078), Scambia G. (ORCID:0000-0003-2758-1063), Testa, Antonia Carla, Ferrandina, Maria Gabriella, Moro, F., Pasciuto, Tina, Moruzzi, M. C., De Blasis, I., Mascilini, Floriana, Foti, E., Autorino, R., Collarino, A., Gui, B., Zannoni, Gian Franco, Gambacorta, Maria Antonietta, Valentini, A. L., Rufini, Vittoria, Scambia, Giovanni, Testa A. C. (ORCID:0000-0003-2217-8726), Ferrandina G. (ORCID:0000-0003-4672-4197), Pasciuto T. (ORCID:0000-0003-2959-8571), Mascilini F., Zannoni G. F. (ORCID:0000-0003-1809-129X), Gambacorta M. A. (ORCID:0000-0001-5455-8737), Rufini V. (ORCID:0000-0002-2052-8078), and Scambia G. (ORCID:0000-0003-2758-1063)
- Abstract
Objective: Chemoradiation-based neoadjuvant treatment followed by radical surgery is an alternative therapeutic strategy for locally advanced cervical cancer (LACC), but ultrasound variables used to predict partial response to neoadjuvant treatment are not well defined. Our goal was to analyze prospectively the potential role of transvaginal ultrasound in early prediction of partial pathological response, assessed in terms of residual disease at histology, in a large, single-institution series of LACC patients triaged to neoadjuvant treatment followed by radical surgery. Methods: Between October 2010 and June 2014, we screened 108 women with histologically documented LACC Stage IB2–IVA, of whom 88 were included in the final analysis. Tumor volume, three-dimensional (3D) power Doppler indices and contrast parameters were obtained before (baseline examination) and after 2 weeks of treatment. The pathological response was defined as complete (absence of any residual tumor after treatment) or partial (microscopic and/or macroscopic residual tumor at pathological examination). Complete-response and partial-response groups were compared and receiver–operating characteristics (ROC) curves were generated for ultrasound variables that were statistically significant on univariate analysis to evaluate their diagnostic ability to predict partial pathological response. Results: There was a complete pathological response to neoadjuvant therapy in 40 (45.5%) patients and a partial response in 48 (54.5%). At baseline examination, tumor volume did not differ between the two groups. However, after 2 weeks of neoadjuvant treatment, the tumor volume was significantly greater in patients with partial response than it was in those with complete response (P = 0.019). Among the 3D vascular indices, the vascularization index (VI) was significantly lower in the partial-response compared with the complete-response group, both before and after 2 weeks of treatment (P = 0.037 and P = 0.024, res
- Published
- 2018
38. PRospective Imaging of CErvical cancer and neoadjuvant treatment (PRICE) study: role of ultrasound to assess residual tumor in locally advanced cervical cancer patients undergoing chemoradiation and radical surgery
- Author
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Testa, Antonia Carla, Moro, Francesca, Pasciuto, Tina, Moruzzi, M. C., Di Legge, A., Fuoco, G., Autorino, R., Collarino, A., Gui, Benedetta, Zannoni, Gian Franco, Gambacorta, Maria Antonietta, Micco', Maura, Rufini, Vittoria, Scambia, Giovanni, Ferrandina, Maria Gabriella, Testa, A. C. (ORCID:0000-0003-2217-8726), Moro, F., Pasciuto, T. (ORCID:0000-0003-2959-8571), Gui, B., Zannoni, G. F. (ORCID:0000-0003-1809-129X), Gambacorta, A. (ORCID:0000-0001-5455-8737), Miccò, M., Rufini, V. (ORCID:0000-0002-2052-8078), Scambia, G. (ORCID:0000-0003-2758-1063), Ferrandina, G. (ORCID:0000-0003-4672-4197), Testa, Antonia Carla, Moro, Francesca, Pasciuto, Tina, Moruzzi, M. C., Di Legge, A., Fuoco, G., Autorino, R., Collarino, A., Gui, Benedetta, Zannoni, Gian Franco, Gambacorta, Maria Antonietta, Micco', Maura, Rufini, Vittoria, Scambia, Giovanni, Ferrandina, Maria Gabriella, Testa, A. C. (ORCID:0000-0003-2217-8726), Moro, F., Pasciuto, T. (ORCID:0000-0003-2959-8571), Gui, B., Zannoni, G. F. (ORCID:0000-0003-1809-129X), Gambacorta, A. (ORCID:0000-0001-5455-8737), Miccò, M., Rufini, V. (ORCID:0000-0002-2052-8078), Scambia, G. (ORCID:0000-0003-2758-1063), and Ferrandina, G. (ORCID:0000-0003-4672-4197)
- Abstract
Objective: To determine the diagnostic performance of two-dimensional (2D) ultrasound parameters, three-dimensional (3D) power Doppler and contrast-enhanced indices in detecting residual disease in locally advanced cervical cancer patients triaged to neoadjuvant treatment followed by radical surgery. Methods: Between October 2010 and June 2014, we screened 108 women with histologically documented locally advanced cervical cancer Stage IB2–IVA, of whom 88 were included in the final analysis. 2D ultrasound parameters, 3D power Doppler and contrast-ultrasound parameters were assessed 5 weeks after the end of neoadjuvant chemoradiation therapy. The pathological response was defined as complete (absence of any residual tumor after treatment) or partial (including microscopic and/or macroscopic residual tumor at pathology examination). The two response groups were compared and receiver–operating characteristics (ROC) curves generated to determine the best cut-off value of sonographic tumor diameter to predict residual disease. Histology was considered as reference. Results: Complete pathological response to chemoradiation was observed in 40 (45.5%) patients and partial response in 48 (54.5%). The presence of residual disease, as confirmed at pathology examination, was detected by 2D grayscale ultrasound with a sensitivity of 64.6% and specificity of 65%. Color Doppler examination in the cases with lesions visualized on grayscale imaging detected the presence of residual disease, confirmed at pathology, with a sensitivity of 87.1% and specificity of 21.4%. The best area under the ROC curve (0.817) was for the detection of pathological residual disease of at least 6 mm in diameter, using a cut-off value of 12 mm for the largest tumor diameter assessed using 2D grayscale ultrasound (sensitivity, 95%; specificity, 70.6%). Neither 3D vascular indices nor contrast-ultrasound parameters obtained for lesions suspected at ultrasound following chemoradiation differed significantly
- Published
- 2018
39. Imaging in gynecological disease (13): clinical and ultrasound characteristics of endometrioid ovarian cancer
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Moro, Francesca, Magoga, G., Pasciuto, Tina, Mascilini, Floriana, Moruzzi, M. C., Fischerova, D., Savelli, L., Giunchi, S., Mancari, R., Franchi, D., Czekierdowski, A., Froyman, W., Verri, D., Epstein, E., Chiappa, V., Guerriero, S., Zannoni, Gian Franco, Timmerman, D., Scambia, Giovanni, Valentin, L., Testa, Antonia Carla, Moro, F., Pasciuto, T. (ORCID:0000-0003-2959-8571), Mascilini, F., Zannoni, G. F. (ORCID:0000-0003-1809-129X), Scambia, G. (ORCID:0000-0003-2758-1063), Testa, A. C. (ORCID:0000-0003-2217-8726), Moro, Francesca, Magoga, G., Pasciuto, Tina, Mascilini, Floriana, Moruzzi, M. C., Fischerova, D., Savelli, L., Giunchi, S., Mancari, R., Franchi, D., Czekierdowski, A., Froyman, W., Verri, D., Epstein, E., Chiappa, V., Guerriero, S., Zannoni, Gian Franco, Timmerman, D., Scambia, Giovanni, Valentin, L., Testa, Antonia Carla, Moro, F., Pasciuto, T. (ORCID:0000-0003-2959-8571), Mascilini, F., Zannoni, G. F. (ORCID:0000-0003-1809-129X), Scambia, G. (ORCID:0000-0003-2758-1063), and Testa, A. C. (ORCID:0000-0003-2217-8726)
- Abstract
OBJECTIVE: To describe the clinical and ultrasound characteristics of ovarian pure endometrioid carcinomas.METHODS: This was a retrospective multicenter study of patients with a histological diagnosis of pure endometrioid carcinoma. We identified 161 patients from the International Ovarian Tumor Analysis (IOTA) database who had undergone preoperative ultrasound examination by an experienced ultrasound examiner between 1999 and 2016, and another 78 patients from the databases of the departments of gynecological oncology in the participating centers. All tumors were described using IOTA terminology. In addition, one author reviewed all available ultrasound images and described them using pattern recognition.RESULTS: Median age of the 239 patients was 55 years (range, 19-88 years). On ultrasound examination, two (0.8%) endometrioid carcinomas were described as unilocular cysts, three (1.3%) as multilocular cysts, 37 (15.5%) as unilocular-solid cysts, 115 (48.1%) as multilocular-solid cysts and 82 (34.3%) as solid masses. Median largest tumor diameter was 102.5 mm (range, 20-300 mm) and median largest diameter of the largest solid component was 63 mm (range, 9-300 mm). Papillary projections were present in 70 (29.3%) masses. Most cancers (188 (78.7%)) were unilateral. In 49 (20.5%) cases, the cancer was judged by the pathologist to develop from endometriosis. These cancers, compared with those without evidence of tumor developing from endometriosis, more often manifested papillary projections on ultrasound (46.9% (23/49) vs 24.7% (47/190)), were less often bilateral (8.2% (4/49) vs 24.7% (47/190)) and less often associated with ascites (6.1% (3/49) vs 28.4% (54/190)) and fluid in the pouch of Douglas (24.5% (12/49) vs 48.9% (93/190)). Retrospective analysis of available ultrasound images using pattern recognition revealed that many tumors without evidence of tumor developing from endometriosis (36.3% (41/113)) had a large central solid component entrapped within locules
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- 2018
40. Ultrasound appearance of breast cancer metastatic to uterine leiomyoma
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Ludovisi, Manuela, Moruzzi, M C, Ferrandina, Maria Gabriella, Scambia, Giovanni, Testa, A C, Ludovisi, M, Ferrandina, G (ORCID:0000-0003-4672-4197), Scambia, G (ORCID:0000-0003-2758-1063), Ludovisi, Manuela, Moruzzi, M C, Ferrandina, Maria Gabriella, Scambia, Giovanni, Testa, A C, Ludovisi, M, Ferrandina, G (ORCID:0000-0003-4672-4197), and Scambia, G (ORCID:0000-0003-2758-1063)
- Abstract
N/A
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- 2018
41. Imaging in gynecological disease (13): clinical and ultrasound characteristics of endometrioid ovarian cancer
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Moro, F., primary, Magoga, G., additional, Pasciuto, T., additional, Mascilini, F., additional, Moruzzi, M. C., additional, Fischerova, D., additional, Savelli, L., additional, Giunchi, S., additional, Mancari, R., additional, Franchi, D., additional, Czekierdowski, A., additional, Froyman, W., additional, Verri, D., additional, Epstein, E., additional, Chiappa, V., additional, Guerriero, S., additional, Zannoni, G. F., additional, Timmerman, D., additional, Scambia, G., additional, Valentin, L., additional, and Testa, A. C., additional
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- 2018
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42. PRospective Imaging of CErvical cancer and neoadjuvant treatment (PRICE) study: role of ultrasound to assess residual tumor in locally advanced cervical cancer patients undergoing chemoradiation and radical surgery
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Testa, A. C., primary, Moro, F., additional, Pasciuto, T., additional, Moruzzi, M. C., additional, Di Legge, A., additional, Fuoco, G., additional, Autorino, R., additional, Collarino, A., additional, Gui, B., additional, Zannoni, G. F., additional, Gambacorta, A., additional, Miccò, M., additional, Rufini, V., additional, Scambia, G., additional, and Ferrandina, G., additional
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- 2018
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43. Ultrasound appearance of breast cancer metastatic to uterine leiomyoma
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Ludovisi, M., primary, Moruzzi, M. C., additional, Ferrandina, G., additional, Scambia, G., additional, and Testa, A. C., additional
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- 2018
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44. PRospective Imaging of CErvical cancer and neoadjuvant treatment (PRICE) study: role of ultrasound to predict partial response in locally advanced cervical cancer patients undergoing chemoradiation and radical surgery
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Testa, A. C., primary, Ferrandina, G., additional, Moro, F., additional, Pasciuto, T., additional, Moruzzi, M. C., additional, De Blasis, I., additional, Mascilini, F., additional, Foti, E., additional, Autorino, R., additional, Collarino, A., additional, Gui, B., additional, Zannoni, G. F., additional, Gambacorta, M. A., additional, Valentini, A. L., additional, Rufini, V., additional, and Scambia, G., additional
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- 2018
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45. Early and late onset complications of gynaecologic surgery: a multimodality imaging approach
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De Blasis, Ilaria, Vinci, V, Sergi, M E, Capozza, F, Saldari, M, Moro, Francesca, Moruzzi, M C, Testa, Antonia Carla, Manganaro, L, De Blasis, I, Moro, F, Testa, Antonia Carla (ORCID:0000-0003-2217-8726), De Blasis, Ilaria, Vinci, V, Sergi, M E, Capozza, F, Saldari, M, Moro, Francesca, Moruzzi, M C, Testa, Antonia Carla, Manganaro, L, De Blasis, I, Moro, F, and Testa, Antonia Carla (ORCID:0000-0003-2217-8726)
- Abstract
N/A
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- 2017
46. Imaging in gynecological disease (12): clinical and ultrasound features of invasive and non-invasive malignant serous ovarian tumors
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Moro, Francesca, Baima Poma, C., Zannoni, Gian Franco, Vidal Urbinati, A., Pasciuto, Tina, Ludovisi, Manuela, Moruzzi, Maria Cristina, Carinelli, S., Franchi, D., Scambia, Giovanni, Testa, Antonia Carla, Moro, F., Zannoni, G. F. (ORCID:0000-0003-1809-129X), Pasciuto, T. (ORCID:0000-0003-2959-8571), Ludovisi, M., Moruzzi, M. C., Scambia, G. (ORCID:0000-0003-2758-1063), Testa, A. C. (ORCID:0000-0003-2217-8726), Moro, Francesca, Baima Poma, C., Zannoni, Gian Franco, Vidal Urbinati, A., Pasciuto, Tina, Ludovisi, Manuela, Moruzzi, Maria Cristina, Carinelli, S., Franchi, D., Scambia, Giovanni, Testa, Antonia Carla, Moro, F., Zannoni, G. F. (ORCID:0000-0003-1809-129X), Pasciuto, T. (ORCID:0000-0003-2959-8571), Ludovisi, M., Moruzzi, M. C., Scambia, G. (ORCID:0000-0003-2758-1063), and Testa, A. C. (ORCID:0000-0003-2217-8726)
- Abstract
Objectives: To describe clinical and ultrasound features of different subclasses of malignant serous ovarian tumors according to the World Health Organization 2014 classification. Methods: Patients with a histological diagnosis of borderline tumor (BOT), non-invasive and invasive low-grade serous carcinoma (LGSC) and high-grade serous carcinoma (HGSC), who had undergone preoperative ultrasound examination, were retrospectively identified from two ultrasound centers. The masses were described using the terms of the International Ovarian Tumor Analysis Group. Results: Sixty-four (15.8%) women had a serous BOT, 11 (2.7%) a non-invasive LGSC, 31 (7.6%) an invasive LGSC and 300 (73.9%) had a HGSC. The vast majority of BOTs (82.3%) and non-invasive LGSCs (90.9%) were Stage I according to the International Federation of Gynecology and Obstetrics (FIGO) classification scheme, whereas most invasive LGSCs (74.2%) and HGSCs (74.0%) were FIGO Stage III. On ultrasound examination, most borderline lesions were described as unilocular-solid (54.7%) or as multilocular-solid (29.7%) cysts. Papillary projections were present in 52 (81.3%) BOTs. Most non-invasive LGSCs (63.6%) were multilocular-solid cysts and 81.8% had papillary projections. Invasive LGSCs were multilocular-solid cysts in 54.8% of cases, and papillary projections were present in 32.3% of lesions. HGSCs were multilocular-solid (32.7%) or solid (64.0%) masses, with papillary projections in only 7% of cases. Conclusions: Papillary projections were the most typical ultrasound feature of non-invasive (borderline and low-grade) malignant serous tumors, while the presence of solid components but few, if any, papillations was the most representative feature of invasive (low-grade and high-grade) serous tumors. Copyright © 2017 ISUOG. Published by John Wiley & Sons Ltd.
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- 2017
47. Ovarian masses with papillary projections diagnosed and removed during pregnancy: ultrasound features and histological diagnoses
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Mascilini, Floriana, Savelli, L, Scifo, M. C, Exacoustos, C, Timor Tritsch, I, De Blasis, Ilaria, Moruzzi, M. C, Pasciuto, Tina, Scambia, Giovanni, Valentin, L, Testa, Antonia Carla, Pasciuto, Tina (ORCID:0000-0003-2959-8571), Scambia, Giovanni (ORCID:0000-0003-2758-1063), Testa, A. C. (ORCID:0000-0003-2217-8726), Mascilini, Floriana, Savelli, L, Scifo, M. C, Exacoustos, C, Timor Tritsch, I, De Blasis, Ilaria, Moruzzi, M. C, Pasciuto, Tina, Scambia, Giovanni, Valentin, L, Testa, Antonia Carla, Pasciuto, Tina (ORCID:0000-0003-2959-8571), Scambia, Giovanni (ORCID:0000-0003-2758-1063), and Testa, A. C. (ORCID:0000-0003-2217-8726)
- Abstract
OBJECTIVES: To elucidate if there are any ultrasound features that can be used to discriminate between benign and malignant cysts with papillary projections but no other solid components in pregnant women. METHODS: Thirty-four women with an ultrasound diagnosis of an ovarian cyst with papillary projections but no other solid components that had been surgically removed during pregnancy were identified from the databases of four ultrasound units. Some clinical and ultrasound information had been collected prospectively. Missing information was obtained retrospectively from ultrasound images, ultrasound reports and patient records. Using the prospectively and retrospectively collected data, the ultrasound appearance of the tumors was described using the terms and definitions of the International Ovarian Tumor Analysis (IOTA) group. The ultrasound characteristics were compared with the histological diagnosis. RESULTS: Nine-teen (56%) lesions were benign (16 decidualized endometriomas, one cystadenofibroma, one simple cyst, one struma ovarii), 12 (35%) borderline tumors, three (9%) primary invasive tumors (two immature teratomas, one endometroid cystadenocarcinoma). The contour of the papillations was smooth in 79% (15/19) of the benign tumors versus in 27% (4/15) of the malignant ones (P = 0.002), ground glass echogenicity of cyst fluid was present in 74% (14/19) versus in 13% (2/15) (P = 0.0005). All ovarian masses with smooth contour of the papillations and ground glass cyst content (n = 12) were decidualized endometriomas. The papillary projections were vascularized and the color score was 3 or 4 in 87% (14/16) of decidualized endometriomas versus in 41% (5/12) of borderline tumors (P = 0.017). CONCLUSIONS: During pregnancy cysts with papillations with smooth contour and ground glass echogenicity of cyst fluid on ultrasound are most likely to be decidualized endometriomas. Papillations with irregular contour and anechoic or low level echogenicity of cyst fluid sugges
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- 2017
48. Ovarian masses with papillary projections diagnosed and removed during pregnancy: ultrasound features and histological diagnosis
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Mascilini, F., primary, Savelli, L., additional, Scifo, M. C., additional, Exacoustos, C., additional, Timor-Tritsch, I. E., additional, De Blasis, I., additional, Moruzzi, M. C., additional, Pasciuto, T., additional, Scambia, G., additional, Valentin, L., additional, and Testa, A. C., additional
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- 2017
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49. Prospective multimodal imaging assessment of locally advanced cervical cancer patients administered by chemoradiation followed by radical surgery. The PRICE (PRospective Imaging of CErvical cancer and neoadjuvant treatment) study 2: the role of ultrasound after chemoradiation to assess residual tumor.
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Testa, A. C., Moro, F., Pasciuto, T., Moruzzi, M. C., Di Legge, A., Fuoco, G., Autorino, R., Collarino, A., Gui, B., Zannoni, G. F., Gambacorta, A., Miccò, M., Rufini, V., Scambia, G., Ferrandina, G., Testa, Antonia Carla, Moro, Francesca, Pasciuto, Tina, Moruzzi, Maria Cristina, and Di Legge, Alessia
- Abstract
Objective: To determine the diagnostic performance of two-dimensional (2D) ultrasound parameters, three-dimensional (3D) power Doppler and contrast-enhanced indices in detecting residual disease in locally advanced cervical cancer patients triaged to neoadjuvant treatment followed by radical surgery.Methods: Between October 2010 and June 2014, we screened 108 women with histologically documented locally advanced cervical cancer Stage IB2-IVA, of whom 88 were included in the final analysis. 2D ultrasound parameters, 3D power Doppler and contrast-ultrasound parameters were assessed 5 weeks after the end of neoadjuvant chemoradiation therapy. The pathological response was defined as complete (absence of any residual tumor after treatment) or partial (including microscopic and/or macroscopic residual tumor at pathology examination). The two response groups were compared and receiver-operating characteristics (ROC) curves generated to determine the best cut-off value of sonographic tumor diameter to predict residual disease. Histology was considered as reference.Results: Complete pathological response to chemoradiation was observed in 40 (45.5%) patients and partial response in 48 (54.5%). The presence of residual disease, as confirmed at pathology examination, was detected by 2D grayscale ultrasound with a sensitivity of 64.6% and specificity of 65%. Color Doppler examination in the cases with lesions visualized on grayscale imaging detected the presence of residual disease, confirmed at pathology, with a sensitivity of 87.1% and specificity of 21.4%. The best area under the ROC curve (0.817) was for the detection of pathological residual disease of at least 6 mm in diameter, using a cut-off value of 12 mm for the largest tumor diameter assessed using 2D grayscale ultrasound (sensitivity, 95%; specificity, 70.6%). Neither 3D vascular indices nor contrast-ultrasound parameters obtained for lesions suspected at ultrasound following chemoradiation differed significantly between patients with histological complete and those with partial response.Conclusions: Our results show that grayscale and color Doppler ultrasound have a low level of diagnostic performance in detecting residual disease after neoadjuvant chemoradiation in patients with locally advanced cervical cancer. The best performance was achieved in detection of macroscopic (≥ 6 mm) residual disease. Copyright © 2018 ISUOG. Published by John Wiley & Sons Ltd. [ABSTRACT FROM AUTHOR]- Published
- 2018
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50. Isterectomia laparoscopica semplice e radicale: terminologia, classificazione e tecnica chirurgica. In: Isterectomia laparoscopica
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Fanfani, F., Gagliardi, M. L., Fagotti, Anna, Vizzielli, G., Moruzzi, M. C., Panico, G., Rossitto, C., Scambia, G., and Ercoli, A.
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- 2012
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