1. On-treatment measurements of circulating tumor DNA during FOLFOX therapy in patients with colorectal cancer
- Author
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Michael R. Speicher, Qing Zhou, Ellen Heitzer, Florian Posch, Karl Kashofer, Sabrina Weber, Ricarda Graf, Jasmin Alia Terzic, Helmut Schoellnast, Sigurd Lax, Julie Waldispuehl-Geigl, Samantha O Hasenleithner, Gerald Hoefler, Jelena Belic, Heinz Sill, Tina Moser, Thomas Bauernhofer, Jochen B. Geigl, Moser, Tina [0000-0001-5211-0920], Hasenleithner, Samantha O [0000-0002-9401-5224], Sill, Heinz [0000-0003-0993-4371], Lax, Sigurd [0000-0002-3576-601X], Heitzer, Ellen [0000-0002-8815-7859], Geigl, Jochen B [0000-0001-9160-0682], Bauernhofer, Thomas [0000-0001-9124-4876], Speicher, Michael R [0000-0003-0105-955X], and Apollo - University of Cambridge Repository
- Subjects
0301 basic medicine ,Oncology ,Cancer Research ,medicine.medical_specialty ,Colorectal cancer ,medicine.medical_treatment ,32 Biomedical and Clinical Sciences ,Brief Communication ,lcsh:RC254-282 ,03 medical and health sciences ,0302 clinical medicine ,Stable Disease ,FOLFOX ,Internal medicine ,Partial response ,medicine ,In patient ,Cell destruction ,Cancer ,Chemotherapy ,business.industry ,3 Good Health and Well Being ,medicine.disease ,lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,3211 Oncology and Carcinogenesis ,Colo-Rectal Cancer ,3204 Immunology ,030104 developmental biology ,Circulating tumor DNA ,030220 oncology & carcinogenesis ,business ,Digestive Diseases ,Biomarkers ,medicine.drug - Abstract
We addressed a significant unknown feature of circulating tumor DNA (ctDNA), i.e., how ctDNA levels change during chemotherapy, by serially monitoring ctDNA in patients with colorectal cancer during the 48-h application of FOLFOX. Surprisingly, we did not observe a spike in ctDNA as a sign of a responsive tumor, but instead ctDNA levels initially decreased and remained low in patients with stable disease or partial response. Our observations reveal further insights into cell destruction during chemotherapy with important implications for the management of patients.
- Published
- 2020
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