13 results on '"Moskal, R."'
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Search Results
2. Measurement of the branching fraction for the decay K-S -> pi mu nu with the KLOE detector
- Author
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Babusci, D., Berlowski, M., Bloise, C., Bossi, F., Branchini, R., Budano, A., Cao, Bo, Ceradini, F., Ciambrone, R., Curciarello, F., Czerwinski, E., D'Agostini, G., Dane, E., De Leo, V, De Lucia, E., De Santis, A., De Simone, R., Di Cicco, A., Di Domenico, A., Domenici, D., D'Uffizi, A., Fantini, A., Fermani, R., Fiore, S., Gajos, A., Gauzzi, R., Giovannella, S., Graziani, E., Ivanov, V. L., Johansson, Tord, Kang, X., Kisielewska-Kaminska, D., Kozyrev, E. A., Krzemien, W., Kupsc, Andrzej, Lukin, P. A., Mandaglio, G., Martini, M., Messi, R., Miscetti, S., Moricciani, D., Moskal, R., Parzych, S., Passeri, A., Patera, V, del Rio, E. Perez, Santangelo, R., Schioppa, M., Selce, A., Silarski, M., Sirghi, F., Solodov, E. P., Tortora, L., Venanzoni, G., Wislicki, W., and Wolke, Magnus
- Subjects
e(+)e(-) collisions ,Subatomär fysik ,Astronomi, astrofysik och kosmologi ,K-0 meson ,Semileptonic decay ,Subatomic Physics ,Astronomy, Astrophysics and Cosmology ,High Energy Physics::Experiment - Abstract
Based on a sample of 300 million K-S mesons produced in phi -> KLKS decays recorded by the KLOE experiment at the DA Phi NE e(+)e(-) collider we have measured the branching fraction for the decay K-S -> pi mu nu. The K-S mesons are identified by the interaction of K-L mesons in the detector. The K-S -> pi mu nu decays are selected by a boosted decision tree built with kinematic variables and by a time-of-flight measurement. Signal efficiencies are evaluated with data control samples of K-L -> pi mu nu decays. A fit to the reconstructed muon mass distribution finds 7223 +/- 180 signal events. Normalising to the K-S -> pi(+)pi(-) decay events the result for the branching fraction is B(K-S -> pi mu nu) = (4.56 +/- 0.11(stat) +/- 0.17(syst)) x 10(-4). It is the first measurement of this decay mode and the result allows an independent determination of vertical bar V-us vertical bar and a test of the lepton-flavour universality. (c) 2020 The Author. Published by Elsevier B.V. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
- Published
- 2020
3. Search for C violation in the decay eta -> pi(0)e(+)e(-) with WASA-at-COSY
- Author
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ADLARSON, R, COLLABORATION, WAC, AUGUSTYNIAK, W, BARDAN, W, BASHKANOV, M, BERGMANN, FS, BERLOWSKI, M, BONDAR, A, BUESCHER, M, CALEN, H, CIEPAL, I, CLEMENT, H, CZERWINSKI, E, DEMMICH, K, ENGELS, R, ERVEN, A, ERVEN, W, EYRICH, W, FEDORETS, R, FOEHL, K, FRANSSON, K, GOLDENBAUM, F, GOSWAMI, A, GRIGORYEV, K, GULLSTROM, CO, HEIJKENSKJOLD, L, HEJNY, V, HUESKEN, N, JARCZYK, L, JOHANSSON, T, KAMYS, B, KEMMERLING, G, KHATRI, G, KHOUKAZ, A, KHREPTAK, A, KIRILLOV, DA, KISTRYN, S, KLEINES, H, KLOS, B, KRZEMIEN, W, KULESSA, R, KUPSC, A, KUZMIN, A, LALWANI, K, LERSCH, D, LORENTZ, B, MAGIERA, A, MAIER, R, MARCINIEWSKI, R, MARIANSKI, B, MORSCH, HP, MOSKAL, R, OHM, H, PAROL, W, RIO, EP, PISKUNOV, NM, PRASUHN, D, PSZCZEL, D, PYSZ, K, PYSZNIAK, A, RITMAN, J, ROY, A, RUDY, Z, RUNDEL, O, SAWANT, S, SCHADMAND, S, SCHATTI-OZERIANSKA, I, SEFZICK, T, SERDYUK, V, SHWARTZ, B, SITTERBERG, K, SKORODKO, T, SKURZOK, M, SMYRSKI, J, SOPOV, V, STASSEN, R, STEPANIAK, J, STEPHAN, E, STERZENBACH, G, STOCKHORST, H, STROEHER, H, SZCZUREK, A, TRZCINSKI, A, WOLKE, M, WRONSKA, A, WUESTNER, R, YAMAMOTO, A, ZABIEROWSKI, J, ZIELINSKI, MJ, ZLOMANCZUK, J, ZUPRANSKI, R, ZUREK, M, and WIRZBA, A
- Subjects
CONSERVING DECAY ,UPPER LIMIT - Abstract
We report on the search for the rare decay eta -> pi(0)e(+)e(-) which is of interest to study C violation in the electromagnetic interaction which would indicate contributions from physics beyond the Standard Model, since the allowed decay via a two-photon intermediate state is strongly suppressed. The experiment has been performed using the WASA-at-COSY installation, located at the COSY accelerator of the Forschungszentrum Julich, Germany. In total 3 x 10(7) events of the reaction pd -> He-3 eta have been recorded at an excess energy of Q = 59.8MeV. Based on this data set the C parity violating decay eta -> pi(0)gamma* -> pi(0)e(+)e(-) via a single-photon intermediate state has been searched for, resulting in new upper limits of Gamma(eta -> pi(0)e(+) e(-))/Gamma(eta -> pi(+) pi(-) pi(0)) < 3.28 x 10(-5) and Gamma(eta -> pi(0)e(+) e(-))/Gamma(eta -> all)< 7.5 x 10(-6) (CL=90%), respectively. (c) 2018 The Author. Published by Elsevier B.V.
- Published
- 2018
- Full Text
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4. Search for C violation in the decay eta -> pi(0)e(+)e(-) with WASA-at-COSY
- Author
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Adlarson, Patrik, Collaboration, WASA-at-COSY, Augustyniak, W., Bardan, W., Bashkanov, M., Bergmann, F. S., Berlowski, M., Bondar, A., Buescher, M., Calén, Hans, Ciepal, I., Clement, H., Czerwinski, E., Demmich, K., Engels, R., Erven, A., Erven, W., Eyrich, W., Fedorets, R., Foehl, K., Fransson, Kjell, Goldenbaum, F., Goswami, A., Grigoryev, K., Gullström, Carl-Oskar, Heijkenskjöld, Lena, Hejny, V., Huesken, N., Jarczyk, L., Johansson, Tord, Kamys, B., Kemmerling, G., Khatri, G., Khoukaz, A., Khreptak, A., Kirillov, D. A., Kistryn, S., Kleines, H., Klos, B., Krzemien, W., Kulessa, R., Kupsc, Andrzej, Kuzmin, A., Lalwani, K., Lersch, D., Lorentz, B., Magiera, A., Maier, R., Marciniewski, Pawel, Marianski, B., Morsch, H. -P, Moskal, R., Ohm, H., Parol, W., del Rio, E. Perez, Piskunov, N. M., Prasuhn, D., Pszczel, Damian, Pysz, K., Pyszniak, Andzej, Ritman, J., Roy, A., Rudy, Z., Rundel, O., Sawant, S., Schadmand, S., Schatti-Ozerianska, I., Sefzick, T., Serdyuk, V., Shwartz, B., Sitterberg, K., Skorodko, T., Skurzok, M., Smyrski, J., Sopov, V., Stassen, R., Stepaniak, J., Stephan, E., Sterzenbach, G., Stockhorst, H., Stroeher, H., Szczurek, A., Trzcinski, A., Wolke, Magnus, Wronska, A., Wuestner, R., Yamamoto, A., Zabierowski, J., Zielinski, M. J., Zlomanczuk, Jozef, Zupranski, R., Zurek, M., and Wirzba, A.
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Subatomär fysik ,Astronomi, astrofysik och kosmologi ,Subatomic Physics ,Astronomy, Astrophysics and Cosmology - Abstract
We report on the search for the rare decay eta -> pi(0)e(+)e(-) which is of interest to study C violation in the electromagnetic interaction which would indicate contributions from physics beyond the Standard Model, since the allowed decay via a two-photon intermediate state is strongly suppressed. The experiment has been performed using the WASA-at-COSY installation, located at the COSY accelerator of the Forschungszentrum Julich, Germany. In total 3 x 10(7) events of the reaction pd -> He-3 eta have been recorded at an excess energy of Q = 59.8MeV. Based on this data set the C parity violating decay eta -> pi(0)gamma* -> pi(0)e(+)e(-) via a single-photon intermediate state has been searched for, resulting in new upper limits of Gamma(eta -> pi(0)e(+) e(-))/Gamma(eta -> pi(+) pi(-) pi(0)) < 3.28 x 10(-5) and Gamma(eta -> pi(0)e(+) e(-))/Gamma(eta -> all)< 7.5 x 10(-6) (CL=90%), respectively.
- Published
- 2018
5. Combined limit on the production of a light gauge boson decaying into mu(+) mu(-) and pi(+) pi(-)
- Author
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Anastasi, A., Babusci, D., Berlowski, M., Bloise, C., Bossi, F., Branchini, R., Budano, A., Cao, Bo, Ceradini, F., Ciambrone, R., Curciarello, F., Czerwinski, E., D'Agostini, G., Dane, E., De Leo, V., De Lucia, E., De Santis, A., De Simone, R., Di Cicco, A., Di Domenico, A., Domenici, D., D'Uffizi, A., Fantini, A., Fantini, G., Fermani, R., Fiore, S., Gajos, A., Gauzzi, R., Giovannella, S., Graziani, E., Ivanov, V. L., Johansson, Tord, Kang, X., Kisielewska-Kaminska, D., Kozyrev, E. A., Krzemien, W., Kupsc, Andrzej, Lukin, P. A., Mandaglio, G., Martini, M., Messi, R., Miscetti, S., Moricciani, D., Moskal, R., Passeri, A., Patera, V., del Rio, E. Perez, Raha, N., Santangelo, R., Schioppa, M., Selce, A., Silarski, M., Sirghi, F., Solodov, E. P., Tortora, L., Venanzoni, G., Wislicki, W., Wolke, Magnus, Anastasi, A., Babusci, D., Berlowski, M., Bloise, C., Bossi, F., Branchini, R., Budano, A., Cao, Bo, Ceradini, F., Ciambrone, R., Curciarello, F., Czerwinski, E., D'Agostini, G., Dane, E., De Leo, V., De Lucia, E., De Santis, A., De Simone, R., Di Cicco, A., Di Domenico, A., Domenici, D., D'Uffizi, A., Fantini, A., Fantini, G., Fermani, R., Fiore, S., Gajos, A., Gauzzi, R., Giovannella, S., Graziani, E., Ivanov, V. L., Johansson, Tord, Kang, X., Kisielewska-Kaminska, D., Kozyrev, E. A., Krzemien, W., Kupsc, Andrzej, Lukin, P. A., Mandaglio, G., Martini, M., Messi, R., Miscetti, S., Moricciani, D., Moskal, R., Passeri, A., Patera, V., del Rio, E. Perez, Raha, N., Santangelo, R., Schioppa, M., Selce, A., Silarski, M., Sirghi, F., Solodov, E. P., Tortora, L., Venanzoni, G., Wislicki, W., and Wolke, Magnus
- Abstract
We searched for the mu(+) mu(-) decay of a light vector gauge boson, also known as dark photon, in the e(+) e(-) -> mu(+) mu(-) gamma(ISR) process by means of the Initial State Radiation (ISR) method. We used 1.93fb(-1) of data collected by the KLOE experiment at the DA Phi NE phi-factory. No structures have been observed over the irreducible mu(+) mu(-) background. A 90% CL limit on the ratio epsilon(2)= alpha'/alpha between the dark coupling constant and the fine structure constant of 3 x 10(-6)-2 x 10(-7) has been set in the dark photon mass region between 519 MeV and 973 MeV. This new limit has been combined with the published result obtained investigating the hypothesis of the dark photon decaying into hadrons in e(+) e(-) -> pi(+) pi(-) gamma(ISR) events. The combined 90% CL limit increases the sensitivity especially in the rho-omega interference region and excludes epsilon(2) greater than (13 - 2) x 10(-7). For dark photon masses greater than 600 MeV the combined limit is lower than 8 x 10(-7) resulting more stringent than present constraints from other experiments.
- Published
- 2018
- Full Text
- View/download PDF
6. Measurement of the running of the fine structure constant below 1 GeV with the KLOE detector
- Author
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Anastasi, A., Babusci, D., Bencivenni, G., Berlowski, M., Bloise, C., Bossi, F., Branchini, R., Budano, A., Caldeira Balkeståhl, Li, Cao, Bo, Ceradini, F., Ciambrone, R., Curciarello, F., Czerwinski, E., D'Agostini, G., Dane, E., De Leo, V., De Lucia, E., De Santis, A., De Simone, R., Di Cicco, A., Di Domenico, A., Di Salvo, R., Domenici, D., D'Uffizi, A., Fantini, A., Felici, G., Fiore, S., Gajos, A., Gauzzi, R., Giardina, G., Giovannella, S., Graziani, E., Happacher, F., Heijkenskjöld, Lena, Johansson, Tord, Kaminska, D., Krzemien, W., Kupsc, Andrzej, Loffredo, S., Lukin, P. A., Mandaglio, G., Martini, M., Mascolo, M., Messi, R., Miscetti, S., Morello, G., Moricciani, D., Moskal, R., Papenbrock, M., Passeri, A., Patera, V., del Rio, E. Perez, Ranieri, A., Santangelo, R., Sarra, I., Schioppa, M., Selce, A., Silarski, M., Sirghi, F., Tortora, L., Venanzoni, G., Wislicki, W., Wolke, M., Jegerlehner, F., Anastasi, A., Babusci, D., Bencivenni, G., Berlowski, M., Bloise, C., Bossi, F., Branchini, R., Budano, A., Caldeira Balkeståhl, Li, Cao, Bo, Ceradini, F., Ciambrone, R., Curciarello, F., Czerwinski, E., D'Agostini, G., Dane, E., De Leo, V., De Lucia, E., De Santis, A., De Simone, R., Di Cicco, A., Di Domenico, A., Di Salvo, R., Domenici, D., D'Uffizi, A., Fantini, A., Felici, G., Fiore, S., Gajos, A., Gauzzi, R., Giardina, G., Giovannella, S., Graziani, E., Happacher, F., Heijkenskjöld, Lena, Johansson, Tord, Kaminska, D., Krzemien, W., Kupsc, Andrzej, Loffredo, S., Lukin, P. A., Mandaglio, G., Martini, M., Mascolo, M., Messi, R., Miscetti, S., Morello, G., Moricciani, D., Moskal, R., Papenbrock, M., Passeri, A., Patera, V., del Rio, E. Perez, Ranieri, A., Santangelo, R., Sarra, I., Schioppa, M., Selce, A., Silarski, M., Sirghi, F., Tortora, L., Venanzoni, G., Wislicki, W., Wolke, M., and Jegerlehner, F.
- Abstract
We have measured the running of the effective QED coupling constant alpha(s) in the time-like region 0.6 < root s < 0.975 GeV with the KLOE detector at DA Phi NE using the Initial-State Radiation process e(+) e(-) -> mu(+) mu(-)gamma. It represents the first measurement of the running of alpha(s) in this energy region. Our results show a more than 5 sigma significance of the hadronic contribution to the running of alpha(s), which is the strongest direct evidence both in time- and space-like regions achieved in a single measurement. By using the e(+) e(-) -> pi(+) pi(-) cross section measured by KLOE, the real and imaginary parts of the shift Delta alpha(s) have been extracted. From a fit of the real part of Delta alpha(s) and assuming the lepton universality the branching ratio BR(omega -> mu(+) mu(-)) = (6.6 +/- 1.4(stat) +/- 1.7(syst)) (.) 10 (5)has been determined., A KLOE-2 Collaboration
- Published
- 2017
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7. Generation of a multipurposePrdm16allele by targeted trapping
- Author
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Strassman, A., primary, Schnütgen, F., additional, Dai, Q., additional, Jones, J. C., additional, Gomez, A. C., additional, Pitstick, L., additional, Holton, N. E., additional, Moskal, R., additional, Leslie, E. R., additional, von Melchner, H., additional, Beier, D. R., additional, and Bjork, B. C., additional
- Published
- 2017
- Full Text
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8. Test of CPT and Lorentz symmetry in entangled neutral kaons with the KLOE experiment
- Author
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Babusci, D., Balwierz Pytko, I., Bencivenni, G., Bloise, C., Bossi, F., Branchini, P., Budano, A., Caldeira Balkestahl, L., Balkestahl, L. C., Caldeirabalkestahl, L., Capon, G., Ceradini, F., Ciambrone, P., Curciarello, F., Czerwin Ski, E., Czerwinski, E., Dane, E., Da Ne, E., De Leo, V., De Lucia, E., De Robertis, G., DE SANTIS, Antonio, De Simone, P., Desimone, P., Di Cicco, A., DI DOMENICO, Antonio, Di Donato, C., Di Salvo, R., Domenici, D., Do Menici, D., Erriquez, O., Fanizzi, G., Fantini, A., Felici, G., Fiore, Salvatore, Franzini, Paolo, Gajos, A., Gauzzi, Paolo, Giardina, G., Giovannella, S., Graziani, E., Happacher, F., Heijkenskjold, L., Hoistad, B., Jacewicz, M., Johansson, T., Kacprzak, K., Kaminska, G. D., Kupsc, A., Lee Franzini, J., Loddo, F., Loffredo, S., Mandaglio, G., Martemianov, M., Martini, M., Mascolo, M., Messi, R., Miscetti, S., Morello, G., Moricciani, D., Moskal, R., Moskal, P., Nguyen, F., Palladino, A., Passeri, A., Patera, Vincenzo, Prado Longhi, I., Longhi, I. P., Pradolonghi, I., Ranieri, A., Santangelo, R., Santangelo, P., Sarra, I., Schioppa, M., Sciascia, B., Silarski, M., Taccini, C., Tortora, L., Venanzoni, G., Wis ́licki, W., Wislicki, W., Wolke, M., Zdebik, J., Babusci, D., Balwierz Pytko, I., Bencivenni, G., Bloise, C., Bossi, F., Branchini, P., Budano, A., Caldeira Balkestahl, L., Capon, G., Ceradini, Filippo, Ciambrone, P., Curciarello, F., Czerwinski, E., Danè, E., De Leo, V., De Lucia, E., De Robertis, G., De Santis, A., De Simone, P., DI CICCO, Alessandro, Di Domenico, A., Di Donato, C., Di Salvo, R., Domenici, D., Erriquez, O., Fanizzi, G., Fantini, A., Felici, G., Fiore, S., Franzini, P., Gajos, A., Gauzzi, P., Giardina, G., Giovannella, S., Graziani, E., Happacher, F., Heijkenskjold, L., Hoistad, B., Jacewicz, M., Johansson, T., Kacprzak, K., Kaminska, D., Kupsc, A., Lee Franzini, J., Loddo, F., Loffredo, Salvatore, Mandaglio, G., Martemianov, M., Martini, M., Mascolo, M., Messi, R., Miscetti, S., Morello, G., Moricciani, D., Moskal, P., Nguyen, F., Palladino, A., Passeri, A., Patera, V., PRADO LONGHI, Ivan, Ranieri, A., Santangelo, P., Sarra, I., Schioppa, M., Sciascia, B., Silarski, M., Taccini, Cecilia, Tortora, L., Venanzoni, G., Wislicki, W., Wolke, M., and Zdebik, J.
- Subjects
Quark ,Particle physics ,Nuclear and High Energy Physics ,lorentz symmetry ,CPT symmetry ,Electron–positron annihilation ,Physics beyond the Standard Model ,FOS: Physical sciences ,Context (language use) ,Lorentz covariance ,$\phi$ -Factory ,01 natural sciences ,High Energy Physics - Experiment ,cpt symmetry ,Nuclear physics ,High Energy Physics - Experiment (hep-ex) ,Standard-Model Extension ,0103 physical sciences ,φ-Factory ,Lorentz symmetry ,Neutral kaons ,neutral kaons ,010306 general physics ,Nuclear Experiment ,Physics ,ϕ-Factory ,Settore FIS/01 ,010308 nuclear & particles physics ,phi-factory ,3. Good health ,φ-factory ,CP violation ,High Energy Physics::Experiment - Abstract
Neutral kaon pairs produced in phi decays in anti-symmetric entangled state can be exploited to search for violation of CPT symmetry and Lorentz invariance. We present an analysis of the CP-violating process phi->K_S K_L->pi+pi-pi+pi- based on 1.7 fb-1 of data collected by the KLOE experiment at the Frascati phi-factory DAFNE. The data are used to perform a measurement of the CPT-violating parameters Delta_amu for neutral kaons in the contest of the Standard Model Extension framework. The parameters measured in the reference frame of the fixed stars are: Delta_ao = (-6.0 +- 7.7_{stat} +- 3.1_{syst}) x 10^{-18} GeV Delta_ax = ( 0.9 +- 1.5_{stat} +- 0.6_{syst}) x 10^{-18} GeV Delta_ay = (-2.0 +- 1.5_{stat} +- 0.5_{syst}) x 10^{-18} GeV Delta_az = ( 3.1 +- 1.7_{stat} +- 0.5_{syst}) x 10^{-18} GeV These are presently the most precise measurements in the quark sector of the Standard Model Extension., 16 pages, 6 figures, added few typo corrections
- Published
- 2014
9. Clinically Relevant Humanized Mouse Models of Metastatic Prostate Cancer Facilitate Therapeutic Evaluation.
- Author
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Kostlan RJ, Phoenix JT, Budreika A, Ferrari MG, Khurana N, Choi JE, Juckette K, Mahapatra S, McCollum BL, Moskal R, Mannan R, Qiao Y, Vander Griend DJ, Chinnaiyan AM, and Kregel S
- Subjects
- Animals, Male, Humans, Mice, Neoplasm Metastasis, Tumor Microenvironment, Immunotherapy methods, Xenograft Model Antitumor Assays, Cell Line, Tumor, Prostatic Neoplasms pathology, Prostatic Neoplasms genetics, Prostatic Neoplasms immunology, Disease Models, Animal
- Abstract
There is tremendous need for improved prostate cancer models. Anatomically and developmentally, the mouse prostate differs from the human prostate and does not form tumors spontaneously. Genetically engineered mouse models lack the heterogeneity of human cancer and rarely establish metastatic growth. Human xenografts are an alternative but must rely on an immunocompromised host. Therefore, we generated prostate cancer murine xenograft models with an intact human immune system (huNOG and huNOG-EXL mice) to test whether humanizing tumor-immune interactions would improve modeling of metastatic prostate cancer and the impact of androgen receptor-targeted and immunotherapies. These mice maintain multiple human immune cell lineages, including functional human T-cells and myeloid cells. Implications: To the best of our knowledge, results illustrate the first model of human prostate cancer that has an intact human immune system, metastasizes to clinically relevant locations, responds appropriately to standard-of-care hormonal therapies, and can model both an immunosuppressive and checkpoint-inhibition responsive immune microenvironment., (©2024 The Authors; Published by the American Association for Cancer Research.)
- Published
- 2024
- Full Text
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10. Clinically relevant humanized mouse models of metastatic prostate cancer to evaluate cancer therapies.
- Author
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Kostlan RJ, Phoenix JT, Budreika A, Ferrari MG, Khurana N, Cho JE, Juckette K, McCollum BL, Moskal R, Mannan R, Qiao Y, Griend DJV, Chinnaiyan AM, and Kregel S
- Abstract
There is tremendous need for improved prostate cancer (PCa) models. The mouse prostate does not spontaneously form tumors and is anatomically and developmentally different from the human prostate. Engineered mouse models lack the heterogeneity of human cancer and rarely establish metastatic growth. Human xenografts represent an alternative but rely on an immunocompromised host. Accordingly, we generated PCa murine xenograft models with an intact human immune system (huNOG and huNOG-EXL mice) to test whether humanizing tumor-immune interactions would improve modeling of metastatic PCa and the impact of hormonal and immunotherapies. These mice maintain multiple human cell lineages, including functional human T-cells and myeloid cells. In 22Rv1 xenografts, subcutaneous tumor size was not significantly altered across conditions; however, metastasis to secondary sites differed in castrate huNOG vs background-matched immunocompromised mice treated with enzalutamide (enza). VCaP xenograft tumors showed decreases in growth with enza and anti-Programed-Death-1 treatments in huNOG mice, and no effect was seen with treatment in NOG mice. Enza responses in huNOG and NOG mice were distinct and associated with increased T-cells within tumors of enza treated huNOG mice, and increased T-cell activation. In huNOG-EXL mice, which support human myeloid development, there was a strong population of immunosuppressive regulatory T-cells and Myeloid-Derived-Suppressor-Cells (MDSCs), and enza treatment showed no difference in metastasis. Results illustrate, to our knowledge, the first model of human PCa that metastasizes to clinically relevant locations, has an intact human immune system, responds appropriately to standard-of-care hormonal therapies, and can model both an immunosuppressive and checkpoint-inhibition responsive immune microenvironment.
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- 2023
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11. Generation of a multipurpose Prdm16 mouse allele by targeted gene trapping.
- Author
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Strassman A, Schnütgen F, Dai Q, Jones JC, Gomez AC, Pitstick L, Holton NE, Moskal R, Leslie ER, von Melchner H, Beier DR, and Bjork BC
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- Animals, Brain metabolism, Breeding, Embryo, Mammalian cytology, Embryonic Stem Cells metabolism, Gene Deletion, Genes, Reporter, Genetic Vectors metabolism, Head embryology, Mice, Mutation genetics, Organ Specificity, Phenotype, Alleles, DNA-Binding Proteins genetics, Gene Targeting, Transcription Factors genetics
- Abstract
Gene trap mutagenesis is a powerful tool to create loss-of-function mutations in mice and other model organisms. Modifications of traditional gene trap cassettes, including addition of conditional features in the form of Flip-excision (FlEx) arrays to enable directional gene trap cassette inversions by Cre and Flpe site-specific recombinases, greatly enhanced their experimental potential. By taking advantage of these conditional gene trap cassettes, we developed a generic strategy for generating conditional mutations and validated this strategy in mice carrying a multipurpose allele of the Prdm16 transcription factor gene. We demonstrate that the gene trap insertion creates a null mutation replicating the Pierre Robin sequence-type cleft palate phenotype of other Prdm16 mutant mice. Consecutive breeding to Flpe and Emx1
IREScre deleter mice spatially restricted Prdm16 loss to regions of the forebrain expressing the homeobox gene Emx1 , demonstrating the utility of the technology for the analysis of tissue-specific gene functions., Competing Interests: Competing interestsThe authors declare no competing or financial interests., (© 2017. Published by The Company of Biologists Ltd.)- Published
- 2017
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12. Persistent melanoma in situ: case report and review.
- Author
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Kemp S, Gallagher G, Kabani S, and Moskal R
- Subjects
- Aged, Humans, Male, Maxillary Neoplasms surgery, Melanoma surgery, Mouth Neoplasms surgery, Rare Diseases pathology, Rare Diseases surgery, Maxillary Neoplasms pathology, Melanoma pathology, Mouth Mucosa pathology, Mouth Neoplasms pathology, Neoplasm Recurrence, Local pathology
- Published
- 2008
- Full Text
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13. Clinical findings among sexually abused children with and without developmental disabilities.
- Author
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Mansell S, Sobsey D, and Moskal R
- Subjects
- Adaptation, Psychological, Child, Child, Preschool, Female, Humans, Male, Child Abuse, Sexual psychology, Developmental Disabilities psychology, Disabled Persons psychology
- Abstract
Although children with developmental disabilities have a heightened risk for sexual abuse compared to those without disabilities, little is known about effects of sexual abuse on this population. Some researchers suggest that the effects are similar, and victims appear to share the same range of variability as people without disabilities. Others suggest that the effects may be complicated by limited coping resources and disability-related issues. Documented effects of sexual abuse on individuals with developmental disabilities was discussed. Clinical findings among a group of 43 children with and 43 children without developmental disabilities referred for treatment of child sexual abuse were also presented.
- Published
- 1998
- Full Text
- View/download PDF
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