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208 results on '"Motomura, Yasuaki"'

6. Sustained effect of leukocytapheresis/granulocytapheresis versus anti-human TNF-α monoclonal antibody on ulcerative colitis: A 2-year retrospective study

Author

Sakai, Masahiro, primary, Hayashi, Koichi, additional, Ito, Tomoyuki, additional, Otani, Haruka, additional, Mori, Yuya, additional, Ito, Shinsuke, additional, Endo, Keita, additional, Matsuda, Hiroto, additional, Yoshino, Kaede, additional, Kitamura, Koichi, additional, Kubota, Eiji, additional, Motomura, Yasuaki, additional, Suzuki, Yasuhiro, additional, Fujitani, Shigeki, additional, and Suzuki, Toshihiko, additional

Published
2023
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10. Sustained effect of leukocytapheresis/granulocytapheresis versus anti-human TNF-α monoclonal antibody on ulcerative colitis - a 2-year retrospective study -

Author

Sakai, Masahiro, primary, Hayashi, Koichi, additional, Ito, Tomoyuki, additional, Otani, Haruka, additional, Mori, Yuya, additional, Ito, Shinsuke, additional, Endo, Keita, additional, Matsuda, Hiroto, additional, Yoshino, Kaede, additional, Kitamura, Koichi, additional, Kubota, Eiji, additional, Motomura, Yasuaki, additional, Suzuki, Yasuhiro, additional, Fujitani, Shigeki, additional, and Suzuki, Toshihiko, additional

Published
2022
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18. Mechanisms underlying gut dysfunction in a murine model of chronic parasitic infection

Author

Motomura, Yasuaki, Khan, Waliul I., El-Sharkawy, Rami T., Verma-Gandhu, Monica, Grencis, Richard K., and Collins, Stephen M.

Subjects
Irritable bowel syndrome -- Physiological aspects, Irritable bowel syndrome -- Care and treatment, Parasitic diseases -- Physiological aspects, Parasitic diseases -- Care and treatment, Cytokines -- Properties, Gastrointestinal system -- Motility, Gastrointestinal system -- Models, Biological sciences
Abstract

Irritable bowel syndrome (IBS) is common in countries where chronic parasitic infestations are endemic. However, the relationship between parasitic infection and IBS is not clear. The aim of this study was to examine whether chronic parasitic infection is accompanied by gut dysfunction and whether the continued presence of the parasite is required for the maintenance of the dysfunction. We used chronic Trichuris muris infection in Th1-biased susceptible AKR mice to evaluate this relationship. AKR mice were infected with T. muris and were euthanized on various days postinfection (pi) to examine worm burden, muscle function, and immune and inflammatory responses. Mice were treated with the anthelmintic oxantel pamoate to assess the effect of eradication of infection on muscle function. Infection resulted in persistence of the parasite, elevated IFN-[gamma], and increased MPO activity evident at 45 days pi. This was accompanied by a reduction in muscle contractility and excitatory innervation. Whereas parasite eradication at 7 days pi normalized IFN-[gamma] and muscle contractility, eradication at 28 days pi failed to normalize muscle contractility. Administration of dexamethasone after parasite eradication normalized all parameters. Anthelmintic treatment improved histology except for eosinophils, which were normalized by subsequent dexamethasone therapy. Persistent gut dysfunction is independent of the continued presence of the parasite and is maintained by inflammatory process that includes eosinophils. Thus data in this preclinical model suggest that parasitic infection could be a cause of IBS, and the lack of symptomatic improvement following eradication is insufficient evidence to refute a causal relationship between the infection and IBS. irritable bowel syndrome; motility; animal model; Thl cytokine; inflammation doi: 10.1152/ajpgi.00324.2010.

Published
2010

23. CD4+ T cell-mediated immunological control of enterochromaffin cell hyperplasia and 5-hydroxytryptamine production in enteric infection

Author

Wang, Huaqing, Steeds, Justin, Motomura, Yasuaki, Deng, Yikang, Verma-Gandhu, Monica, El-Sharkawy, Rami T., McLaughlin, John T., Grencis, Richard K., and Khan, Waliul I.

Subjects
CD4 lymphocytes -- Research, Irritable bowel syndrome -- Causes of, Serotonin -- Physiological aspects, Serotonin -- Research, Chromaffin cells -- Physiological aspects, Health
Published
2007

31. Gastric Glomus Tumor Diagnosed by Endoscopic Ultrasound-Guided Fine-Needle Aspiration Biopsy : Report of a Case

Author

Minoda, Yosuke, Akahoshi, Kazuya, Oya, Masafumi, Kubokawa, Masaru, Motomura, Yasuaki, and Nakamura, Kazuhiko

Subjects
Glomus tumor, EUS-FNA, Submucosal tumor, グロムス腫瘍, digestive system diseases, 粘膜下腫瘍
Abstract

A glomus tumor of the stomach is rare. It is difficult to diagnose the tumor before surgery by only endoscopic biopsy and radiography, and there is no established method of diagnosis before surgical treatment. Esophagogastroduodenoscopy (EGD) on a 50-year-old Japanese woman revealed a 10mm submucosal tumor in the anterior wall of the gastric angle. Follow-up EGD revealed an increase in the size of the tumor to 15mm. Endoscopic ultrasonography (EUS) demonstrated a 15mm subepithelial hypoechoic solid tumor with continuity to the proper muscle layer. Histologic diagnosis by endoscopic ultrasonography guided fine needle aspiration (EUS-FNA) was glomus tumor. The tumor was treated by laparoscopic local resection. The histologic diagnosis of the resected tumor was similar to the preoperative EUS-FNA results. EUS-FNA would appear to be an effective histologic test for early diagnosis of gastric glomus tumor., 胃グロムス腫瘍はまれな疾患であり，上部消化管内視鏡検査(EGD)による生検や画像診断のみでは手術前に診断に至ることは難しい．現在のところ胃グロムス腫瘍を術前に診断することは困難である．症例は50歳の日本人女性．近医にて施行されたEGDにて胃角部前壁に10mm大の粘膜下腫瘍を指摘された．1年後のフォローアップのEGDでサイズは15mm大に増大しており精査加療のため当院を紹介された．当院で施行した超音波内視鏡検査(EUS)で粘膜下に筋層と連続する15mm大の低エコー充実性腫瘤を指摘．超音波内視鏡下穿刺吸引法(EUS-FNA)を施行しグロムス腫瘍と病理組織学的に診断した．当院外科へ紹介し腹腔鏡下胃局所切除術が施行され，術後の病理組織は術前のEUS-FNAで採取された組織とほぼ同様でグロムス腫瘍と診断された．EUS-FNAは胃グロムス腫瘍の早期診断に有用な方法であると考えられた．

Published
2014

35. Newly Developed All in One EUS System : One Cart System, Forward-Viewing Optics Type 360°Electronic Radial Array Echoendoscope and Oblique-Viewing Type Convex Array Echoendoscope

Author

Akahoshi, Kazuya, Tanaka, Toshizumi, Matsui, Noriaki, Kubokawa, Masaru, Motomura, Yasuaki, Honda, Kuniomi, Murata, Atsuhiko, Ouchi, Jiro, Kimura, Mitsuhide, and Endo, Shingo

Subjects
digestive system diseases
Abstract

Most endosonographers use radial scanning instruments for diagnostic imaging, and use longitudinal scanning instruments primarily for endoscopic ultrasoundguided fine needle aspiration (EUS-FNA). The use of two separate instruments for radial and longitudinal scanning means 2 different echoendoscopes are required,each with its own dedicated US processing unit. Currently available electronic radial echoendoscopes and linear instruments made by the same company require the same other brand US unit. Furthermore,no forward-viewing optics type 360°electronic radial echoendoscope currently exists. We have developed an all-in-one one cart EUS system that saves space and is available for both the forward-viewing type 360°radial electronic echoendoscope and the oblique-viewing type convex echoendoscope. These scopes have a transducer with variable frequency (5.0, 7.5, 10.0, 12.0 MHz) and color and power Doppler flow mapping capabilities. We performed a clinical development test for thirteen patients with sixteen lesions (Radial EUS on 8 lesions and EUS-FNA on 8 lesions)using this new EUS system. These new instruments provided satisfactory US and endoscopic images. The forward-viewing optics of the prototype enhanced intubation and instrument advancement. The radial scanning prototype provided an adequate diagnosis in 8(100%) out of 8 lesions for EUS. The convex type achieved successful puncture in 8 (100%)out of 8 lesions and collection of adequate specimen for diagnosis of EUS-FNA in 4(50%)out of 8 lesions. There were no complications in this series. This new system appears to be an attractive alternative for efficient EUS.

Published
2007

37. Is double-balloon colonoscopy a better aid to unskilled colonoscopists than conventional colonoscopy?

Author

Okamoto, Risa, Motomura, Yasuaki, Akahoshi, Kazuya, Kashiwabara, Yumi, Endo, Shingo, Higuchi, Naomi, Oda, Manami, Kubokawa, Masaru, Matsui, Noriaki, Nakamura, Kazuhiko, and Takayanagi, Ryoichi

Subjects
Adult, Aged, 80 and over, Double-Balloon Enteroscopy, Male, training, Humans, Female, Clinical Competence, Colonoscopy, technique, Middle Aged, double-balloon colonoscopy, Aged
Abstract

Background and study aims : To compare the clinical outcome of double-balloon colonoscopy (DBC) with conventional colonoscopy (CC) for colon evaluation performed by an unskilled colonoscopist. Patientes and methods : Between June 2008 and November 2008, 1544 colonoscopies were performed in our hospital. Fifty-eight patients, (29 male and 29 female ; 19-86 years; mean age, 63 years) involving 60 intubations, were enrolled in this study and were assigned randomly to the DBC or CC group. One first-year GI fellow was enrolled and performed these 60 consecutive colonoscopies (30 DBCs, 30 CCs). Completion rate of colonoscopy, cecal intubation time, and rate of analgesic agent usage were analyzed. Results : Completion of DBC was 100% (30/30), while completion of CC was 73% (22/30). There was a statistically significant difference (p < 0.05). The mean cecal intubation time was 36.2 ± 14.4 minutes (DBC) and 36.5 ± 15.2 minutes (CC). There was no statistically significant difference. Analgesic agent was used with 19 intubations (63%) (DBC) and with 27 intubations (90%) (CC) (p < 0.05). Conclusions : For inexpert endoscopists, using DBC has a higher rate of effectiveness than using CC and can decrease the discomfort of patients during colonoscopic procedures., 【目的】最近日本では大腸癌の罹患率が急速に増加しており，前癌病変の早期発見早期治療が望まれる．しかし，内視鏡医にとって，通常内視鏡を使用し盲腸まで難なく到達できるようになるまでには，訓練が必要である．又，訓練を積んだ内視鏡医においても，盲腸までの挿入到達率は平均90-95％と言われている．そこで我々は，特定の一人の初心者内視鏡医に，通常大腸内視鏡とダブルバルーン大腸内視鏡の両方を使用させ，挿入成績に関して検討を行った．【方法】施行医は，初心者内視鏡医1 名．対象は，2008年6月から2008年11 月の間に，麻生飯塚病院消化器内科に来院した患者58 人60 例（男29 人，女29 人；19 - 86 歳，平均年齢63歳）．施行前にコンピューターでランダムに，(A）ダブルバルーン大腸内視鏡（B）通常大腸内視鏡，に割付けし，その挿入成績を検討した．【結果】各々の内視鏡での盲腸挿入成績は，(A）100％（30/30 例）(B）73％（22/30 例）と両群間に差を認めた．盲腸までの挿入時間は，(A）平均36.2± 14.4分（B）平均36.5± 15.2分であり，有意差は認めなかった．検査中患者が苦痛を感じ，鎮静剤を使用した場合は，(A）63％（19/30例）(B）90％（27/30例）で，両群間に差を認めた．ダブルバルーン大腸内視鏡を使用することで，全例が挿入可能であり，苦痛度の軽減が得られた．全ての症例で偶発症はなかった．【結論】ダブルバルーン大腸内視鏡を使用することにより，初心者内視鏡医でも容易に盲腸への到達が可能であり，安全で苦痛の少ない内視鏡検査が可能になると思われた．

Published
2012

38. Successful EUS-guided drainage of the abscess in the abdominal cavity consequent to the gastric surgery: Report of a case

Author

Nakamura Kazuhiko, Kimura Kazue, Endoh Shingo, Oya Masafumi, Motomura Yasuaki, Kubokawa Masaru, Akahoshi Kazuya, Honda Kuniomi, Matsui Noriaki, and Watanabe Masayuki

Subjects
medicine.medical_specialty, medicine.anatomical_structure, business.industry, Gastroenterology, Medicine, Abdominal cavity, business, Abscess, medicine.disease, Eus guided drainage, Surgery
Published
2011
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39. Endoscopic Submucosal Dissection for Early Gastric Cancer using the Clutch Cutter: a large single-center experience

Author

Akahoshi, Kazuya, additional, Motomura, Yasuaki, additional, Kubokawa, Masaru, additional, Gibo, Junya, additional, Kinoshita, Nobukatsu, additional, Osada, Shigeki, additional, Tokumaru, Kayo, additional, Hosokawa, Taizou, additional, Tomoeda, Naru, additional, Otsuka, Yoshihiro, additional, Matsuo, Mie, additional, Oya, Masafumi, additional, Koga, Hidenobu, additional, and Nakamura, Kazuhiko, additional

Published
2015
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41. Tu1740 Does Lactate Predict Inpatient Mortality and Morbidity in Acute Upper Gastrointestinal Bleeding?

Author

Miyazaki, Takehiro, primary, Akahoshi, Kazuya, additional, Koga, Hidenobu, additional, Miyagaki, Aki, additional, Kubokawa, Masaru, additional, Motomura, Yasuaki, additional, Gibo, Junya, additional, Kinoshita, Nobukatsu, additional, Osada, Shigeki, additional, Shimokawa, Yuzo, additional, Tokumaru, Kayo, additional, Otsuka, Yoshihiro, additional, Tomoeda, Naru, additional, Utsunomiya, Ran, additional, Miyamoto, Kazuaki, additional, Baba, Yoko, additional, and Hosokawa, Taizou, additional

Published
2015
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42. Suitability of the expanded indication criteria for the treatment of early gastric cancer by endoscopic submucosal dissection: Japanese multicenter large-scale retrospective analysis of short- and long-term outcomes

Author

Nakamura, Kazuhiko, primary, Honda, Kuniomi, additional, Akahoshi, Kazuya, additional, Ihara, Eikichi, additional, Matsuzaka, Hiroshi, additional, Sumida, Yorinobu, additional, Yoshimura, Daisuke, additional, Akiho, Hirotada, additional, Motomura, Yasuaki, additional, Iwasa, Tsutomu, additional, Komori, Keishi, additional, Chijiiwa, Yoshiharu, additional, Harada, Naohiko, additional, Ochiai, Toshiaki, additional, Oya, Masafumi, additional, Oda, Yoshinao, additional, and Takayanagi, Ryoichi, additional

Published
2015
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44. Endoscopic ultrasound diagnosis of a small splenic vein aneurysm

Author

Komori, Keishi, additional, Akahoshi, Kazuya, additional, Motomura, Yasuaki, additional, Kubokawa, Masaru, additional, Gibo, Junya, additional, Kanayama, Kenji, additional, Fukuda, Shinichiro, additional, Hamada, Shohei, additional, Otuka, Yoshiaki, additional, and Nakamura, Kazuhiko, additional

Published
2014
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46. Endoscopic submucosal dissection using the “Clutch Cutter” for early esophageal squamous cell carcinoma

Author

Akahoshi, Kazuya, additional, Minoda, Yousuke, additional, Komori, Keishi, additional, Motomura, Yasuaki, additional, Kubokawa, Masaru, additional, Otsuka, Yoshihiro, additional, Hamada, Syouhei, additional, Fukuda, Shinichirou, additional, Iwao, Risa, additional, Gibo, Junya, additional, Oya, Masafumi, additional, and Nakamura, Kazuhiko, additional

Published
2013
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47. Characteristics of Hemorrhagic Peptic Ulcers in Patients Receiving Antithrombotic/Nonsteroidal Antiinflammatory Drug Therapy

Author

Nakamura, Kazuhiko, primary, Akahoshi, Kazuya, additional, Ochiai, Toshiaki, additional, Komori, Keishi, additional, Haraguchi, Kazuhiro, additional, Tanaka, Munehiro, additional, Nakamura, Norimoto, additional, Tanaka, Yoshimasa, additional, Kakigao, Kana, additional, Ogino, Haruei, additional, Ihara, Eikichi, additional, Akiho, Hirotada, additional, Motomura, Yasuaki, additional, Kabemura, Teppei, additional, Harada, Naohiko, additional, Chijiiwa, Yoshiharu, additional, Ito, Tetsuhide, additional, and Takayanagi, Ryoichi, additional

Published
2012
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48. Predictive Factors for Colonic Diverticular Rebleeding: A Retrospective Analysis of the Clinical and Colonoscopic Features of 111 Patients

Author

Tanaka, Yoshimasa, primary, Motomura, Yasuaki, additional, Akahoshi, Kazuya, additional, Iwao, Risa, additional, Komori, Keishi, additional, Nakama, Naotaka, additional, Osoegawa, Takashi, additional, Itaba, Soichi, additional, Kubokawa, Masaru, additional, Hisano, Terumasa, additional, Ihara, Eikichi, additional, Nakamura, Kazuhiko, additional, and Takayanagi, Ryoichi, additional

Published
2012
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50. Regulatory T cells expanded by rapamycin in vitro suppress colitis in an experimental mouse model

Author

Ogino, Haruei, primary, Nakamura, Kazuhiko, additional, Iwasa, Tsutomu, additional, Ihara, Eikich, additional, Akiho, Hirotada, additional, Motomura, Yasuaki, additional, Akahoshi, Kazuya, additional, Igarashi, Hisato, additional, Kato, Masaki, additional, Kotoh, Kazuhiro, additional, Ito, Tetsuhide, additional, and Takayanagi, Ryoichi, additional

Published
2011
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