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4. The long Pentraxin PTX3 serves as an early predictive biomarker of co-infections in COVID-19

Author

Accornero, Stefano, Aghemo, Alessio, Ali, Hussam, Angelini, Claudio, Arcari, Ivan, Arosio, Paola, Azzolini, Elena, Baccarin, Alessandra, Badalamenti, Salvatore, Baggio, Sara, Barbagallo, Michela, Barberi, Caterina, Barbic, Franca, Barbieri, Viviana, Barbone, Alessandro, Basciu, Alessio, Bocciolone, Monica, Borea, Federica, Borroni, Mario, Bresciani, Gianluigi, Brunetta, Enrico, Bulletti, Cinzia, Cadonati, Cristina, Calabro', Lorenzo, Calatroni, Marta, Calvetta Albania, Antonietta, Cannata, Francesco, Canziani, Lorenzo, Capretti Giovanni, Luigi, Carlani, Elisa, Carrone, Flaminia, Casana, Maddalena, Cecconi, Maurizio, Ceriotti, Carlo, Ciccarelli, Michele, Cimino, Matteo, Ciuffini, Leonardo, Colaizzi, Chiara, Colapietro, Francesca, Costa, Guido, Cozzi, Ottavia, Craviotto, Vincenzo, Crespi, Chiara, Crippa, Massimo, Da Rio, Leonardo, Dal Farra, Sara, D'Antonio, Federica, De Ambroggi, Guido, De Donato, Massimo, De Lucia, Francesca, De Santis, Maria, Delle Rose, Giacomo, Di Pilla, Marina, Dipaola, Franca, Dipasquale, Andrea, Dipasquale, Angelo, Droandi, Ginevra, Fazio, Roberta, Ferrante, Giuseppe, Ferrara Elisa, Chiara, Ferrari Matteo, Carlo, Ferri, Sebastian, Folci, Marco, Foresti, Sara, Franchi, Eloisa, Fraolini, Elia, Fugazza, Alessandro, Furfaro, Federica, Galimberti, Paola, Galtieri Alessia, Piera, Gavazzi, Francesca, Generali, Elena, Goletti, Benedetta, Guidelli, Giacomo, Jacobs, Flavia, Kurihara, Hayato, Lagioia, Michele, Libre', Luca, Lleo, Ana, Loiacono, Ferdinando, Lughezzani, Giovanni, Maccallini, Marta, Maiorino Alfonso, Francesco, Malesci, Alberto, Mantovani, Riccardo, Marchettini, Davide, Marinello, Arianna, Markopoulos, Nikolaos, Masetti, Chiara, Milani, Angelo, Mirani, Marco, Morelli, Paola, Motta, Francesca, Mundula, Valeria, Nigro, Mattia, Omodei, Paolo, Ormas, Monica, Pagliaro, Arianna, Paliotti, Roberta, Parigi Tommaso, Lorenzo, Pedale, Rosa, Pegoraro, Francesco, Pellegatta, Gaia, Pellegrino, Marta, Petriello, Gennaro, Piccini, Sara, Pocaterra, Daria, Poliani, Laura, Preatoni, Paoletta, Procopio, Fabio, Puggioni, Francesca, Pugliese, Luca, Racca, Francesca, Randazzo, Michele, Regazzoli Lancini, Damiano, Reggiani, Francesco, Rodolfi, Stefano, Ruongo, Lidia, Sacco, Clara, Sandri Maria, Teresa, Savi, Marzia, Scarfo', Iside, Shiffer, Dana, Sicoli, Federico, Solano, Simone, Solitano, Virginia, Stainer, Anna, Stella Matteo, Carlo, Strangio, Giuseppe, Taormina, Antonio, Testoni, Lucia, Tordato, Federica, Trabucco, Angela, Ulian, Luisa, Valentino, Rossella, Valeriano, Chiara, Vena, Walter, Verlingieri, Simona, Vespa, Edoardo, Voza, Antonio, Zanuso, Valentina, Zilli, Alessandra, Anfray, Clement, Belgiovine, Cristina, Bertocchi, Alice, Bombace, Sara, Brescia, Paola, Calcaterra, Francesca, Calvi, Michela, Cancellara, Assunta, Capucetti, Arianna, Carenza, Claudia, Carloni, Sara, Carnevale, Silvia, Cazzetta, Valentina, Coianiz, Nicolò, Darwich, Abbass, Davoudian, Sadaf, De Paoli, Federica, Di Donato, Rachele, Digifico, Elisabeth, Durante, Barbara, Farina Floriana, Maria, Ferrari, Valentina, Fornasa, Giulia, Franzese, Sara, Ghasemi, Somayehsadat, Gil Gomez, Antonio, Giugliano, Silvia, Gomes Ana, Rita, Lizier, Michela, Lo Cascio, Antonino, Melacarne, Alessia, Mozzarelli, Alessandro, My, Ilaria, Oresta, Bianca, Pasqualini, Fabio, Pastò, Anna, Pelamatti, Erica, Perucchini, Chiara, Pozzi, Chiara, Rimoldi, Valeria, Rimoldi, Monica, Scarpa, Alice, Scavello, Francesco, Silvestri, Alessandra, Sironi, Marina, Spadoni, Ilaria, Spano', Salvatore, Spata, Gianmarco, Supino, Domenico, Tentorio, Paolo, Ummarino, Aldo, Valentino, Sonia, Zaghi, Elisa, Zanon, Veronica, Mapelli, Sarah N., Nappi, Emanuele, García Martín, Ian David, Leone, Roberto, Angelotti, Giovanni, Zhong, Hang, Magrini, Elena, Stravalaci, Matteo, Protti, Alessandro, Santini, Alessandro, Costantini, Elena, Savevski, Victor, Bottazzi, Barbara, Bartoletti, Michele, Mantovani, Alberto, and Garlanda, Cecilia

Published
2024
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9. Antibody glycosylation in autoimmune diseases

Author

Zhou, Xing, Motta, Francesca, Selmi, Carlo, Ridgway, William M, Gershwin, M Eric, and Zhang, Weici

Subjects
Biomedical and Clinical Sciences, Immunology, Autoimmune Disease, Arthritis, Lupus, Digestive Diseases, Inflammatory and immune system, Good Health and Well Being, Arthritis, Rheumatoid, Autoimmune Diseases, Autoimmunity, Glycosylation, Humans, Lupus Erythematosus, Systemic, Antibody, Inflammation, Fc fragment, Clinical sciences
Abstract

The glycosylation of the fragment crystallizable (Fc) region of immunoglobulins (Ig) is critical for the modulation of antibody effects on inflammation. Moreover, antibody glycosylation may induce pathologic modifications and ultimately contribute to the development of autoimmune diseases. Thanks to progress in the analysis of glycosylation, more data are available on IgG and its subclass structures in the context of autoimmune diseases. In this review, we focused on the impact of Ig glycosylation in autoimmunity, describing how it modulates the immune response and how glycome profiles can be used as biomarkers of disease activity. The analysis of antibody glycosylation demonstrated specific features in human autoimmune and chronic inflammatory conditions, including rheumatoid arthritis, systemic lupus erythematosus, inflammatory bowel disease and autoimmune liver diseases, among others. Within the same disease, different patterns are associated with disease severity and treatment options. Future research may increase the information available on the distinct glycome profiles and expand their potential role as biomarkers and as targets for treatment, ultimately favoring an individualized approach.

Published
2021

11. Recommendations for coronavirus infection in rheumatic diseases treated with biologic therapy

Author

Ceribelli, Angela, Motta, Francesca, De Santis, Maria, Ansari, Aftab A, Ridgway, William M, Gershwin, M Eric, and Selmi, Carlo

Subjects
Medical Microbiology, Biomedical and Clinical Sciences, Clinical Sciences, Immunology, Infectious Diseases, Arthritis, Emerging Infectious Diseases, Autoimmune Disease, Prevention, Vaccine Related, Lung, Biodefense, 5.1 Pharmaceuticals, Development of treatments and therapeutic interventions, Infection, Inflammatory and immune system, Good Health and Well Being, Antibodies, Monoclonal, Humanized, Antimalarials, Antirheumatic Agents, Azetidines, Betacoronavirus, Biological Therapy, COVID-19, Coronavirus Infections, Cytokines, Humans, Immunosuppressive Agents, Interleukin-1, Interleukin-6, Pandemics, Pneumonia, Viral, Purines, Pyrazoles, Rheumatic Diseases, SARS-CoV-2, Sulfonamides, Virus Internalization, COVID-19 Drug Treatment, CoViD-19, SARS-CoV2, Rheumatic diseases, Tocilizumab, Baricitinib
Abstract

The Coronavirus-associated disease, that was first identified in 2019 in China (CoViD-19), is a pandemic caused by a bat-derived beta-coronavirus, named SARS-CoV2. It shares homology with SARS and MERS-CoV, responsible for past outbreaks in China and in Middle East. SARS-CoV2 spread from China where the first infections were described in December 2019 and is responsible for the respiratory symptoms that can lead to acute respiratory distress syndrome. A cytokine storm has been shown in patients who develop fatal complications, as observed in past coronavirus infections. The management includes ventilatory support and broad-spectrum antiviral drugs, empirically utilized, as a targeted therapy and vaccines have not been developed. Based upon our limited knowledge on the pathogenesis of CoViD-19, a potential role of some anti-rheumatic drugs may be hypothesized, acting as direct antivirals or targeting host immune response. Antimalarial drugs, commonly used in rheumatology, may alter the lysosomal proteases that mediates the viral entry into the cell and have demonstrated efficacy in improving the infection. Anti-IL-1 and anti-IL-6 may interfere with the cytokine storm in severe cases and use of tocilizumab has shown good outcomes in a small cohort. Baricitinib has both antiviral and anti-inflammatory properties. Checkpoints inhibitors such as anti-CD200 and anti-PD1 could have a role in the treatment of CoViD-19. Rheumatic disease patients taking immunosuppressive drugs should be recommended to maintain the chronic therapy, prevent infection by avoiding social contacts and pausing immunosuppressants in case of infection. National and international registries are being created to collect data on rheumatic patients with CoViD-19.

Published
2020

13. Systemic syndromes of rheumatological interest with onset after COVID-19 vaccine administration: a report of 30 cases

Author

Ursini, Francesco, Ruscitti, Piero, Raimondo, Vincenzo, De Angelis, Rossella, Cacciapaglia, Fabio, Pigatto, Erika, Olivo, Domenico, Di Cola, Ilenia, Galluccio, Felice, Francioso, Francesca, Foti, Rosario, Tavoni, Antonio Gaetano, D’Angelo, Salvatore, Campochiaro, Corrado, Motta, Francesca, De Santis, Maria, Bilia, Silvia, Bruno, Caterina, De Luca, Giacomo, Visentini, Marcella, Ciaffi, Jacopo, Mancarella, Luana, Brusi, Veronica, D’Onghia, Martina, Cuomo, Giovanna, Fusaro, Enrico, Cipriani, Paola, Dagna, Lorenzo, Guiducci, Serena, Meliconi, Riccardo, Iannone, Florenzo, Iagnocco, Annamaria, Giacomelli, Roberto, and Ferri, Clodoveo

Published
2022
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14. Evolution of brain injury and neurological dysfunction after cardiac arrest in the rat – A multimodal and comprehensive model.

Author

Perego, Carlo, Fumagalli, Francesca, Motta, Francesca, Cerrato, Marianna, Micotti, Edoardo, Olivari, Davide, De Giorgio, Daria, Merigo, Giulia, Di Clemente, Angelo, Mandelli, Alessandra, Forloni, Gianluigi, Cervo, Luigi, Furlan, Roberto, Latini, Roberto, Neumar, Robert W, and Ristagno, Giuseppe

Abstract

Cardiac arrest (CA) is one of the leading causes of death worldwide. Due to hypoxic ischemic brain injury, CA survivors may experience variable degrees of neurological dysfunction. This study, for the first time, describes the progression of CA-induced neuropathology in the rat. CA rats displayed neurological and exploratory deficits. Brain MRI revealed cortical and striatal edema at 3 days (d), white matter (WM) damage in corpus callosum (CC), external capsule (EC), internal capsule (IC) at d7 and d14. At d3 a brain edema significantly correlated with neurological score. Parallel neuropathological studies showed neurodegeneration, reduced neuronal density in CA1 and hilus of hippocampus at d7 and d14, with cells dying at d3 in hilus. Microgliosis increased in cortex (Cx), caudate putamen (Cpu), CA1, CC, and EC up to d14. Astrogliosis increased earlier (d3 to d7) in Cx, Cpu, CC and EC compared to CA1 (d7 to d14). Plasma levels of neurofilament light (NfL) increased at d3 and remained elevated up to d14. NfL levels at d7 correlated with WM damage. The study shows the consequences up to 14d after CA in rats, introducing clinically relevant parameters such as advanced neuroimaging and blood biomarker useful to test therapeutic interventions in this model. [ABSTRACT FROM AUTHOR]

Published
2024
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15. Osteoblast Response to Widely Ranged Texturing Conditions Obtained through High Power Laser Beams on Ti Surfaces.

Author

Ruffinatti, Federico Alessandro, Genova, Tullio, Roato, Ilaria, Perin, Martina, Chinigò, Giorgia, Pedraza, Riccardo, Della Bella, Olivio, Motta, Francesca, Aimo Boot, Elisa, D'Angelo, Domenico, Gatti, Giorgio, Scarpellino, Giorgia, Munaron, Luca, and Mussano, Federico

Subjects
HIGH power lasers, FREE surfaces, FACTOR analysis, REGRESSION analysis, DENTAL materials, CELL adhesion
Abstract

Titanium and titanium alloys are the prevailing dental implant materials owing to their favorable mechanical properties and biocompatibility, but how roughness dictates the biological response is still a matter of debate. In this study, laser texturing was used to generate eight paradigmatic roughened surfaces, with the aim of studying the early biological response elicited on MC3T3-E1 pre-osteoblasts. Prior to cell tests, the samples underwent SEM analysis, optical profilometry, protein adsorption assay, and optical contact angle measurement with water and diiodomethane to determine surface free energy. While all the specimens proved to be biocompatible, supporting similar cell viability at 1, 2, and 3 days, surface roughness could impact significantly on cell adhesion. Factorial analysis and linear regression showed, in a robust and unprecedented way, that an isotropic distribution of deep and closely spaced valleys provides the best condition for cell adhesion, to which both protein adsorption and surface free energy were highly correlated. Overall, here the authors provide, for the first time, a thorough investigation of the relationship between roughness parameters and osteoblast adhesion that may be applied to design and produce new tailored interfaces for implant materials. [ABSTRACT FROM AUTHOR]

Published
2024
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19. Validation of the Italian version of the ANCA-associated vasculitis patient-reported outcome (AAV-PRO) questionnaire

Author

Treppo, Elena, primary, Isola, Miriam, additional, De Martino, Maria, additional, Padoan, Roberto, additional, Giollo, Alessandro, additional, Urban, Maria Letizia, additional, Monti, Sara, additional, Sartorelli, Silvia, additional, Fassio, Angelo, additional, Argolini, Lorenza Maria, additional, Marvisi, Chiara, additional, Gattamelata, Angelica, additional, Regola, Francesca, additional, Ferro, Francesco, additional, Cassone, Giulia, additional, Motta, Francesca, additional, Berti, Alvise, additional, Conticini, Edoardo, additional, Guiducci, Serena, additional, Matucci-Cerinic, Marco, additional, Lo Gullo, Alberto, additional, Manfredi, Andreina, additional, Frediani, Bruno, additional, Bortolotti, Roberto, additional, Selmi, Carlo, additional, Baldini, Chiara, additional, Franceschini, Franco, additional, Conti, Fabrizio, additional, Caporali, Roberto, additional, Rossini, Maurizio, additional, Dagna, Lorenzo, additional, Montecucco, Carlomaurizio, additional, Emmi, Giacomo, additional, Schiavon, Franco, additional, Salvarani, Carlo, additional, and Quartuccio, Luca, additional

Published
2024
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20. Higher levels of IgA and IgG at sepsis onset are associated with higher mortality: results from the Albumin Italian Outcome Sepsis (ALBIOS) trial

Author

Alagna, Laura, Meessen, Jennifer M. T. A., Bellani, Giacomo, Albiero, Daniela, Caironi, Pietro, Principale, Irene, Vivona, Luigi, Grasselli, Giacomo, Motta, Francesca, Agnelli, Nicolò M., Parrini, Vieri, Romagnoli, Stefano, Keim, Roberto, Di Marzo Capozzi, Francesca, Taccone, Fabio S., Taccone, Walter, Bottazzi, Barbara, Bandera, Alessandra, Cortegiani, Andrea, and Latini, Roberto

Published
2021
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30. Inflammatory rheumatic diseases with onset after SARS-CoV-2 infection or COVID-19 vaccination: a report of 267 cases from the COVID-19 and ASD group

Author

Ursini, Francesco, primary, Ruscitti, Piero, additional, Addimanda, Olga, additional, Foti, Rosario, additional, Raimondo, Vincenzo, additional, Murdaca, Giuseppe, additional, Caira, Virginia, additional, Pigatto, Erika, additional, Cuomo, Giovanna, additional, Lo Gullo, Alberto, additional, Cavazzana, Ilaria, additional, Campochiaro, Corrado, additional, Naclerio, Caterina, additional, De Angelis, Rossella, additional, Ciaffi, Jacopo, additional, Mancarella, Luana, additional, Brusi, Veronica, additional, Marchetti, Elena, additional, Motta, Francesca, additional, Visentini, Marcella, additional, Lorusso, Sebastiano, additional, De Santis, Maria, additional, De Luca, Giacomo, additional, Massaro, Laura, additional, Olivo, Domenico, additional, Pellegrini, Roberta, additional, Francioso, Francesca, additional, Luppino, Jessica, additional, Di Cola, Ilenia, additional, Foti, Roberta, additional, Varcasia, Giuseppe, additional, Caso, Francesco, additional, Reta, Massimo, additional, Dagna, Lorenzo, additional, Selmi, Carlo, additional, Iagnocco, Annamaria, additional, Giacomelli, Roberto, additional, Iannone, Florenzo, additional, and Ferri, Clodoveo, additional

Published
2023
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31. Validation of the Italian version of the ANCA-associated vasculitis patient-reported outcome (AAV-PRO) questionnaire.

Author

Tripp, Elena, Isola, Miriam, De Martino, Maria, Padoan, Roberto, Giollo, Alessandro, Urban, Maria Letizia, Monti, Sara, Sartorelli, Silvia, Fassio, Angelo, Argolini, Lorenza Maria, Marvisi, Chiara, Gattamelata, Angelica, Regola, Francesca, Ferro, Francesco, Cassone, Giulia, Motta, Francesca, Berti, Alvise, Conticini, Edoardo, Guiducci, Serena, and Matucci-Cerinic, Marco

Published
2024
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33. Inflammatory rheumatic diseases with onset after SARS-CoV-2 infection or COVID-19 vaccination: a report of 267 cases from the COVID-19 and ASD group

Author

Ursini, Francesco, Ruscitti, Piero, Addimanda, Olga, Foti, Rosario, Raimondo, Vincenzo, Murdaca, Giuseppe, Caira, Virginia, Pigatto, Erika, Cuomo, Giovanna, Lo Gullo, Alberto, Cavazzana, Ilaria, Campochiaro, Corrado, Naclerio, Caterina, De Angelis, Rossella, Ciaffi, Jacopo, Mancarella, Luana, Brusi, Veronica, Marchetti, Elena, Motta, Francesca, Visentini, Marcella, Lorusso, Sebastiano, De Santis, Maria, De Luca, Giacomo, Massaro, Laura, Olivo, Domenico, Pellegrini, Roberta, Francioso, Francesca, Luppino, Jessica, Di Cola, Ilenia, Foti, Roberta, Varcasia, Giuseppe, Caso, Francesco, Reta, Massimo, Dagna, Lorenzo, Selmi, Carlo, Iagnocco, Annamaria, Giacomelli, Roberto, Iannone, Florenzo, and Ferri, Clodoveo

Subjects
Arthritis, Autoimmune Diseases, COVID-19, Polymyalgia Rheumatica, Vaccination
Published
2023

38. Characterization of the Cardiac Structure and Function of Conscious D2.B10- Dmd mdx /J (D2- mdx) mice from 16–17 to 24–25 Weeks of Age.

Author

De Giorgio, Daria, Novelli, Deborah, Motta, Francesca, Cerrato, Marianna, Olivari, Davide, Salama, Annasimon, Fumagalli, Francesca, Latini, Roberto, Staszewsky, Lidia, Crippa, Luca, Steinkühler, Christian, and Licandro, Simonetta Andrea

Subjects
MICE, DUCHENNE muscular dystrophy, VENTRICULAR remodeling, GENETIC disorders, HEART fibrosis, HEART diseases
Abstract

Duchenne muscular dystrophy (DMD) is the most common form of muscle degenerative hereditary disease. Muscular replacement by fibrosis and calcification are the principal causes of progressive and severe musculoskeletal, respiratory, and cardiac dysfunction. To date, the D2.B10-Dmdmdx/J (D2-mdx) model is proposed as the closest to DMD, but the results are controversial. In this study, the cardiac structure and function was characterized in D2-mdx mice from 16–17 up to 24–25 weeks of age. Echocardiographic assessment in conscious mice, gross pathology, and histological and cardiac biomarker analyses were performed. At 16–17 weeks of age, D2-mdx mice presented mild left ventricular function impairment and increased pulmonary vascular resistance. Cardiac fibrosis was more extended in the right ventricle, principally on the epicardium. In 24–25-week-old D2-mdx mice, functional and structural alterations increased but with large individual variation. High-sensitivity cardiac Troponin T, but not N-terminal pro-atrial natriuretic peptide, plasma levels were increased. In conclusion, left ventricle remodeling was mild to moderate in both young and adult mice. We confirmed that right ventricle epicardial fibrosis is the most outstanding finding in D2-mdx mice. Further long-term studies are needed to evaluate whether this mouse model can also be considered a model of DMD cardiomyopathy. [ABSTRACT FROM AUTHOR]

Published
2023
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39. The Preventive Role of Physical Activity in Systemic Sclerosis: A Cross-Sectional Study on the Correlation with Clinical Parameters and Disease Progression

Author

Antinozzi, Cristina, primary, Grazioli, Elisa, additional, De Santis, Maria, additional, Motta, Francesca, additional, Sgrò, Paolo, additional, Mari, Federico, additional, Mauri, Caterina, additional, Parisi, Attilio, additional, Caporossi, Daniela, additional, Duranti, Guglielmo, additional, Ceci, Roberta, additional, Di Luigi, Luigi, additional, and Dimauro, Ivan, additional

Published
2022
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44. Low-energy pulsed electromagnetic field therapy reduces pain in fibromyalgia: A randomized single-blind controlled pilot study

Author

Giovale, Massimo, primary, Novelli, Lucia, additional, Persico, Luca, additional, Motta, Francesca, additional, Rampoldi, Stefano, additional, Galli, Rossana, additional, Monteforte, Patrizia, additional, Doveri, Marica, additional, Bianchi, Gerolamo, additional, Selmi, Carlo, additional, and Bottaro, Luigi Carlo, additional

Published
2022
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48. Dose-Dependent Impairment of the Immune Response to the Moderna-1273 mRNA Vaccine by Mycophenolate Mofetil in Patients with Rheumatic and Autoimmune Liver Diseases

Author

De Santis, Maria, primary, Motta, Francesca, additional, Isailovic, Natasa, additional, Clementi, Massimo, additional, Criscuolo, Elena, additional, Clementi, Nicola, additional, Tonutti, Antonio, additional, Rodolfi, Stefano, additional, Barone, Elisa, additional, Colapietro, Francesca, additional, Ceribelli, Angela, additional, Vecellio, Matteo, additional, Luciano, Nicoletta, additional, Guidelli, Giacomo, additional, Caprioli, Marta, additional, Rezk, Clara, additional, Canziani, Lorenzo, additional, Azzolini, Elena, additional, Germagnoli, Luca, additional, Mancini, Nicasio, additional, Lleo, Ana, additional, and Selmi, Carlo, additional

Published
2022
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49. mRNA COVID-19 vaccine booster fosters B- and T-cell responses in immunocompromised patients

Author

Azzolini, Elena, primary, Pozzi, Chiara, additional, Germagnoli, Luca, additional, Oresta, Bianca, additional, Carriglio, Nicola, additional, Calleri, Mariella, additional, Selmi, Carlo, additional, De Santis, Maria, additional, Finazzi, Silvia, additional, Carlo-Stella, Carmelo, additional, Bertuzzi, Alexia, additional, Motta, Francesca, additional, Ceribelli, Angela, additional, Mantovani, Alberto, additional, Bonelli, Fabrizio, additional, and Rescigno, Maria, additional

Published
2022
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