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239 results on '"Mottola, M."'

1. Mercury's geochronology revised by applying Model Production Functions to Mariner 10 data: geological implications

Author

Massironi, M., Cremonese, G., Marchi, S., Martellato, M., Mottola, M., and Wagner, R. J.

Subjects
Astrophysics - Earth and Planetary Astrophysics
Abstract

Model Production Function chronology uses dynamic models of the Main Belt Asteroids (MBAs) and Near Earth Objects (NEOs) to derive the impactor flux to a target body. This is converted into the crater size-frequency-distribution for a specific planetary surface, and calibrated using the radiometric ages of different regions of the Moon's surface. This new approach has been applied to the crater counts on Mariner 10 images of the highlands and of several large impact basins on Mercury. MPF estimates for the plains show younger ages than those of previous chronologies. Assuming a variable uppermost layering of the Hermean crust, the age of the Caloris interior plains may be as young as 3.59 Ga, in agreement with MESSENGER results that imply that long-term volcanism overcame contractional tectonics. The MPF chronology also suggests a variable projectile flux through time, coherent with the MBAs for ancient periods and then gradually comparable also to the NEOs., Comment: Accepted by Journal Geophysical Research Letters

Published
2009
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2. URINARY, BOWEL AND SEXUAL FUNCTION OF TRANSGENDER WOMEN AFTER SEX REASSIGNMENT SURGERY VAGINOPLASTY: CROSS-SECTIONAL STUDY

Author

Lima Martins, K, primary, Sarkis Oliveira, P, additional, Azevedo, M, additional, Cecchi Salata, M, additional, Franções Porto, D, additional, Amaral Pequeno, S, additional, Martinez David, M, additional, Shimohara Bradaschia, J, additional, da Silva Souza, S, additional, Henriques Jácomo, R, additional, Lucena da Silva, M, additional, Azevedo Garcia, P, additional, Barbaresco Gomide Matheus, L, additional, Armando Nunes de Lima, E, additional, Tirolli Rett, M, additional, Paplinskie, S, additional, Hosein, K, additional, Mottola, M, additional, and Teixeira Alves, A, additional

Published
2023
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3. 312 - URINARY, BOWEL AND SEXUAL FUNCTION OF TRANSGENDER WOMEN AFTER SEX REASSIGNMENT SURGERY VAGINOPLASTY: CROSS-SECTIONAL STUDY

Author

Lima Martins, K, Sarkis Oliveira, P, Azevedo, M, Cecchi Salata, M, Franções Porto, D, Amaral Pequeno, S, Martinez David, M, Shimohara Bradaschia, J, da Silva Souza, S, Henriques Jácomo, R, Lucena da Silva, M, Azevedo Garcia, P, Barbaresco Gomide Matheus, L, Armando Nunes de Lima, E, Tirolli Rett, M, Paplinskie, S, Hosein, K, Mottola, M, and Teixeira Alves, A

Published
2023
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4. Beyond multiparametric MRI and towards radiomics to detect prostate cancer: A machine learning model to predict clinically significant lesions

Author

Bianchi, L., primary, Gaudiano, C., additional, Mottola, M., additional, Corcioni, B., additional, Tonin, E., additional, Droghetti, M., additional, Cattabriga, A., additional, Cocozza, M.A., additional, Palmeri, A., additional, Coppola, F., additional, Giunchi, F., additional, Schiavina, R., additional, Fiorentino, M., additional, Brunocilla, E., additional, Golfieri, R., additional, and Bevilacqua, A., additional

Published
2023
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5. Signals of pseudo-starvation unveil the amino acid transporter SLC7A11 as key determinant in the control of Treg cell proliferative potential

Author

Procaccini, C, Garavelli, S, Carbone, F, Di Silvestre, D, La Rocca, C, Greco, D, Colamatteo, A, Lepore, M, Russo, C, De Rosa, G, Faicchia, D, Prattichizzo, F, Grossi, S, Campomenosi, P, Buttari, F, Mauri, P, Uccelli, A, Salvetti, M, Brescia Morra, V, Vella, D, Galgani, M, Mottola, M, Zuccarelli, B, Lanzillo, R, Maniscalco, G, Centonze, D, de Candia, P, Matarese, G, Procaccini C., Garavelli S., Carbone F., Di Silvestre D., La Rocca C., Greco D., Colamatteo A., Lepore M. T., Russo C., De Rosa G., Faicchia D., Prattichizzo F., Grossi S., Campomenosi P., Buttari F., Mauri P., Uccelli A., Salvetti M., Brescia Morra V., Vella D., Galgani M., Mottola M., Zuccarelli B., Lanzillo R., Maniscalco G. T., Centonze D., de Candia P., Matarese G., Procaccini, C, Garavelli, S, Carbone, F, Di Silvestre, D, La Rocca, C, Greco, D, Colamatteo, A, Lepore, M, Russo, C, De Rosa, G, Faicchia, D, Prattichizzo, F, Grossi, S, Campomenosi, P, Buttari, F, Mauri, P, Uccelli, A, Salvetti, M, Brescia Morra, V, Vella, D, Galgani, M, Mottola, M, Zuccarelli, B, Lanzillo, R, Maniscalco, G, Centonze, D, de Candia, P, Matarese, G, Procaccini C., Garavelli S., Carbone F., Di Silvestre D., La Rocca C., Greco D., Colamatteo A., Lepore M. T., Russo C., De Rosa G., Faicchia D., Prattichizzo F., Grossi S., Campomenosi P., Buttari F., Mauri P., Uccelli A., Salvetti M., Brescia Morra V., Vella D., Galgani M., Mottola M., Zuccarelli B., Lanzillo R., Maniscalco G. T., Centonze D., de Candia P., and Matarese G.

Abstract

Human CD4+CD25hiFOXP3+ regulatory T (Treg) cells are key players in the control of immunological self-tolerance and homeostasis. Here, we report that signals of pseudo-starvation reversed human Treg cell in vitro anergy through an integrated transcriptional response, pertaining to proliferation, metabolism, and transmembrane solute carrier transport. At the molecular level, the Treg cell proliferative response was dependent on the induction of the cystine/glutamate antiporter solute carrier (SLC)7A11, whose expression was controlled by the nuclear factor erythroid 2-related factor 2 (NRF2). SLC7A11 induction in Treg cells was impaired in subjects with relapsing-remitting multiple sclerosis (RRMS), an autoimmune disorder associated with reduced Treg cell proliferative capacity. Treatment of RRMS subjects with dimethyl fumarate (DMF) rescued SLC7A11 induction and fully recovered Treg cell expansion. These results suggest a previously unrecognized mechanism that may account for the progressive loss of Treg cells in autoimmunity and unveil SLC7A11 as major target for the rescue of Treg cell proliferation.

Published
2021

7. Quality, Features, and Presence of Behavior Change Techniques in Mobile Apps Designed to Improve Physical Activity in Pregnant Women: Systematic Search and Content Analysis

Author

Hayman, M, Alfrey, K-L, Cannon, S, Alley, S, Rebar, AL, Williams, S, Short, CE, Altazan, A, Comardelle, N, Currie, S, Denton, C, Harrison, CL, Lamerton, T, Mena, GP, Moran, L, Mottola, M, Nagpal, TS, Vincze, L, Schoeppe, S, Hayman, M, Alfrey, K-L, Cannon, S, Alley, S, Rebar, AL, Williams, S, Short, CE, Altazan, A, Comardelle, N, Currie, S, Denton, C, Harrison, CL, Lamerton, T, Mena, GP, Moran, L, Mottola, M, Nagpal, TS, Vincze, L, and Schoeppe, S

Abstract

BACKGROUND: Physical activity during pregnancy is associated with several health benefits for the mother and child. However, very few women participate in regular physical activity during pregnancy. eHealth platforms (internet and mobile apps) have become an important information source for pregnant women. Although the use of pregnancy-related apps has significantly increased among pregnant women, very little is known about their theoretical underpinnings, including their utilization of behavior change techniques (BCTs). This is despite research suggesting that inclusion of BCTs in eHealth interventions are important for promoting healthy behaviors, including physical activity. OBJECTIVE: The aim of this study was to conduct a systematic search and content analysis of app quality, features, and the presence of BCTs in apps designed to promote physical activity among pregnant women. METHODS: A systematic search in the Australian App Store and Google Play store using search terms relating to exercise and pregnancy was performed. App quality and features were assessed using the 19-item Mobile App Rating Scale (MARS), and a taxonomy of BCTs was used to determine the presence of BCTs (26 items). BCTs previously demonstrating efficacy in behavior changes during pregnancy were also identified from a literature review. Spearman correlations were used to investigate the relationships between app quality, app features, and number of BCTs identified. RESULTS: Nineteen exercise apps were deemed eligible for this review and they were accessed via Google Play (n=13) or App Store (n=6). The MARS overall quality scores indicated moderate app quality (mean 3.5 [SD 0.52]). Functionality was the highest scoring MARS domain (mean 4.2 [SD 0.5]), followed by aesthetics (mean 3.7 [SD 0.6]) and information quality (mean 3.16 [SD 0.42]). Subjective app quality (mean 2.54 [SD 0.64]) and likelihood for behavioral impact (mean 2.5 [SD 0.6]) were the lowest scoring MARS domains. All 19 apps wer

Published
2021

8. Impact of different values of prosthesis–patient mismatch on outcome in male patients with aortic valve replacement

Author

Mannacio VA, Mannacio L, Antignano A, Pinna GB, Giordano R, Mottola M, Iannelli G., IANNELLI, GABRIELE, Mannacio, Va, Mannacio, L, Antignano, A, Pinna, Gb, Giordano, R, Mottola, M, Iannelli, G., and Iannelli, Gabriele

Subjects
Male, medicine.medical_specialty, Time Factors, Databases, Factual, medicine.medical_treatment, 030204 cardiovascular system & hematology, Prosthesis Design, Prosthesis, Ventricular Function, Left, Left ventricular mass, 03 medical and health sciences, 0302 clinical medicine, Aortic valve replacement, Risk Factors, Internal medicine, Humans, Medicine, In patient, Aged, Retrospective Studies, Heart Valve Prosthesis Implantation, Ventricular Remodeling, business.industry, Effective orifice area, Aortic Valve Stenosis, General Medicine, Middle Aged, medicine.disease, Aortic valve replacement Prosthesis-patient mismatch Risk stratification Surgery Ventricular hypertrophy, Surgery, Treatment Outcome, 030228 respiratory system, Male patient, Aortic Valve, Heart Valve Prosthesis, Cardiology, Hypertrophy, Left Ventricular, Cardiology and Cardiovascular Medicine, business
Abstract

Aims Mortality and left ventricular mass (LVM) recovery/regression after aortic valve replacement in patients with prosthesis-patient mismatch (PPM) is controversial. This study evaluated the impact of different values of indexed effective orifice area (EOAi) in male patients on mortality and indexed LVM (ILVM) recovery/regression. Method The study recruited 376 male patients with and without PPM after aortic valve replacement with different EOAi cut-off values. Results At EOAi 0.85 cm2/m2 or less, 295 patients had PPM (78.5%). ILVM recovery occurred in 60.5% of no-PPM patients versus 46.1% of patients with PPM (P = 0.003), and ILVM regression was 35 versus 25% (P < 0.001). Time for ILVM regression was shorter in no-PPM group. At EOAi 0.75 cm2/m2 or less, 201 patients had PPM (53.4%). ILVM recovery occurred in 55.4% of no-PPM patients versus 45.2% of patients with PPM (P = 0.06), regression was 32 versus 29% (P = 0.09). Time for ILVM regression was similar between groups. Regardless the cut-off value for PPM definition, mortality was similar. Conclusion LVM recovery/regression, but not mortality, was different at different EOAi. The cut-off value at EOAi 0.75 cm2/m2 or less guaranteed a more balanced patient distribution between groups and the best compromise between specificity and sensitivity

Published
2017

12. RF19 ENDOVASCULAR SURGERY FOR TYBE B AORTIC DISSECTION

Author

Scigliano, F., Di Tommaso, L., Di Tommaso, E., Mottola, M., Fontana, I., Tozzi, A., Pilato, E., Iannelli, G., Scigliano, F., Di Tommaso, L., Di Tommaso, E., Mottola, M., Fontana, I., Tozzi, A., Pilato, E., and Iannelli, G.

Published
2018

36. ENDOVASCULAR SURGERY FOR THORACIC AORTIC PATHOLOGY

Author

IANNELLI, GABRIELE, MONACO M., DI TOMMASO L., MOTTOLA M., PINNA G., DE AMICIS, VINCENZO, SARNO G., PISCIONE F., Iannelli, Gabriele, Monaco, M., DI TOMMASO, L., Mottola, M., Pinna, G., DE AMICIS, Vincenzo, Sarno, G., and Piscione, F.

Published
2005

37. ACUTE TYPE-B AORTIC DISSECTION:IMPACT OF ENDOVASCULAR SURGERY

Author

TRUNFIO S., MONACO M., DI TOMMASO L., MOTTOLA M., TROISI N., BOTTA L., PISCIONE F., IANNELLI, GABRIELE, Trunfio, S., Monaco, M., DI TOMMASO, L., Mottola, M., Troisi, N., Botta, L., Piscione, F., and Iannelli, Gabriele

Published
2004

42. Cardiovascular monitoring of drug-resistant lymphomapatients treated with epoch chemotherapy plus high-dose verapamil in continuous-infusion

Author

Tagliaferri P, Correale P, Mottola M, Desimone G, Rea A, Ascione R, MorabitoA, Matano E, Montesarchio V, CARAGLIA, Michele, Tortora G, Barile C, Palmieri G, Bianco A., CIARDIELLO, Fortunato, Tagliaferri, P, Correale, P, Mottola, M, Desimone, G, Rea, A, Ascione, R, Morabitoa, Matano, E, Montesarchio, V, Caraglia, Michele, Tortora, G, Ciardiello, Fortunato, Barile, C, Palmieri, G, and Bianco, A.

Published
1994

45. A Formal Approach to Ontology-Based Semantic Match of Skills Descriptions

Author

Colucci, S., Di Noia, T., Di Sciascio, E., Donini, Fm, Marina Mongiello, and Mottola, M.

Subjects
skill management, matchmaking, knowledge representation, ontologies, Knowledge representation
Abstract

Skills management has been recently acknowledged as one of the key factors to adequately face the increasing competitiveness between knowledge intensive companies. In this paper we present a formal approach to Ontology-Based Semantic Matchmaking between Skills demand and supply, devised as a virtual marketplace of knowledge. In such a knowledge market metaphor, skills are a peculiar kind of good that has distinguishing characteristics with respect to traditional assets. Buyers are entities that need the skills of people, such as projects, departments and organizations, sellers are workers that offer their own skills. The formal framework supports the semantic match of descriptions provided by demanders and sellers of skills. In particular our approach, based on Description Logics formalization and reasoning, overcomes simple subsumption matching and allows match ranking and categorization. The implementation of the approach in a prototype system, which embeds a NeoClassic reasoner, is also described.

Published
2003

47. Translating Healthy Living Messages to Postpartum Women and Their Partners After Gestational Diabetes (GDM): Body Habitus, A1C, Lifestyle Habits, and Program Engagement Results From the Families Defeating Diabetes (FDD) Randomized Trial

Author

McManus, R., Miller, D., Mottola, M., Giroux, I., and Donovan, L.

Abstract

Purpose: The Families Defeating Diabetes intervention evaluated a postpartum healthy living program for women with recent gestational diabetes mellitus (GDM).Design: Randomized controlled trial.Setting: Tertiary centers in London, Calgary, and Victoria, Canada.Participants: Women with GDM and partners; 46% of eligible maternal participants agreed to participate.Intervention: Interventional (INT) participants received a healthy living seminar at 3 months; access to a walking group/Website; biweekly e-mails. Control (CON) participants received a contemporary postpartum diabetes prevention handout.Measures: Maternal, partner, and offspring demographics at baseline, 3, and 12 months.Analysis: Percentages of women losing ≥7% of postpartum weight were compared by χ2testing; body habitus comparisons by analysis of covariance (ANCOVA); maternal A1C comparisons by unpaired ttests; participant outcome associations by Pearson correlation coefficients.Results: Maternal participants were 170 (89 INT and 81 CON) with 63 partners (30 INT and 33 CON); 103 (73 maternal; 30 partners) were lost to follow-up; 57% of maternal participants completed 12 months; 33% INT women (n = 50) lost ≥7% weight versus 25% CON women (n = 47), P= .43. Interventional participant results did not correlate with accession of study elements. Maternal completion was significantly associated with partner involvement, breastfeeding, higher income, and education. Paternal weights correlated significantly with maternal and offspring weights.Conclusion: Families Defeating Diabetes outcomes were not significantly different for INT maternal or paternal participants versus CON participants. Secondary outcomes of future value included statistically significant positive associations between paternal participation, socioeconomic indicators, and maternal study completion, significant correlations between maternal, paternal, and offspring weights as well as insights into study component engagement.

Published
2018
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49. Phase I clinical trial of high dose recombinant interleukin-2/veparimil combination in advancer cancer

Author

Tagliaferri, P., Correale, P., Mottola, M., DE SIMONE, G., Montesarchio, V., Matano, E., Rea, A., Morabito, A., Famiani, M., Ciardiello, F., Tortora, Giampaolo, Caraglia, M., Guarrasi, R., Barile, C., Palmieri, G., Bianco, A. R., Tagliaferri, P., Correale, P., Mottola, Michele, DE SIMONE, Giovanni, Montesarchio, V., Matano, Elide, Rea, A., Morabito, A., Famiani, M., Ciardiello, F., Tortora, Giampaolo, Caraglia, M., Guarrasi, R., Barile, C., Palmieri, Giovannella, and Bianco, A. R.

Subjects
Clinical trial, IL-2, veparimil
Published
1996

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