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Guilherme Moura Cunha,1 Victoria Chernyak,2 Kathryn J Fowler,1 Claude B Sirlin1 1Liver Imaging Group, Department of Radiology, University of California San Diego, La Jolla, CA, USA; 2Department of Radiology, Beth Israel Deaconess Medical Center, Boston, MA, USACorrespondence: Guilherme Moura CunhaLiver Imaging Group, Department of Radiology, University of California San Diego, 9500 Gilman Dr. Mail Code 0888, La Jolla, San Diego, CA, 92093, USAEmail gcunha@uw.eduAbstract: Hepatocellular carcinoma (HCC) is a leading cause of mortality worldwide and a major healthcare burden in most societies. Computed tomography (CT) and magnetic resonance imaging (MRI) play a pivotal role in the medical care of patients with or at risk for hepatocellular carcinoma (HCC). When stringent imaging criteria are fulfilled, CT and MRI allow for diagnosis, staging, and assessment of response to treatment, without the need for invasive workup, and can inform clinical decision making. Owing to the central role of these imaging modalities in HCC management, standardization is essential to facilitate proper imaging technique, accurate interpretation, and clear communication among all stakeholders in both the clinical practice and research settings. The Liver Imaging Reporting and Data System (LI-RADS) is a comprehensive system that provides standardization across the continuum of HCC imaging, including ordinal probabilistic approach for reporting that directs individualized management. This review discusses the up-to-date role of CT and MRI in HCC imaging from the LI-RADS perspective. It also provides a glimpse into the future by discussing how advances in knowledge and technology are likely to enrich the LI-RADS approach.Keywords: hepatocellular carcinoma, computed tomography, magnetic resonance imaging, LI-RADS

This paper analyzes, through a diachronic view about the formation of brazilian cinema, reactions in reply to production of Marighella (2019), film directed by Wagner Moura. From a clipping of the reader-response criticism proposed by Metz (1977) in semiology of the cinema, I intend to argue how the brazilian film is seen about to be released, according ideological aspects who creates the social representation and the cinematographic critics. Therefore, I follow a relation with the ideas of verbal interaction and dialogism, theorized by Bakhtin (2002; 2003; 2013a; 2013b) and Bakhtin/Volóchinov (2014), the definition of semiotic-ideological unity as expression of human language. Then, I realize a research in brazilian social network Filmow, where films can be rated and reviewed, to analyze the content of the published comments. Based on a qualitative observation of twenty posts, I find an effervescent discussion about the representation of the main character and the metacritics, critics about critics. Este artigo visa analisar, através de um olhar diacrônico sobre a formação do cinema nacional, uma série de reações expressas diante da produção de Marighella (2019), filme de Wagner Moura. A partir de um recorte da estética da recepção de Metz (1977), formulada pela semiologia do cinema, pretende-se discutir como a obra brasileira é vista na emergência de seu lançamento, considerando aspectos ideológicos que moldam a representação social e a crítica cinematográfica. Para depreender as ideologias em jogo, faz-se também um diálogo com as noções de interação verbal e dialogismo, de Bakhtin (2002; 2003; 2013a; 2013b) e Bakhtin/Volóchinov (2014), que preconizam a articulação semiótico-ideológica do signo como expressão máxima da linguagem humana. A partir dessas bases, realiza-se um estudo na rede social brasileira Filmow, destinada à catalogação e à avaliação de obras fílmicas, para analisar a natureza dos comentários publicados sobre o filme selecionado. Dessa maneira, por uma observação qualitativa de vinte críticas, depreende-se um efervescente embate em torno da imagem do guerrilheiro e uma sobreposição da metacrítica, que lança juízos de valor sobre as avaliações dos demais usuários.

Purpose To perform an international survey on current practices in imaging-based surveillance, diagnosis, staging, and assessment of treatment response for HCC. Materials and methods Three themes were covered in this international survey: demographics of respondents and liver imaging expertise; imaging practices for screening, surveillance, diagnosis, staging, and assessment of treatment response for HCC; and diagnostic imaging systems used. Descriptive summaries were created. Results Of 151 respondents, 22.5% were from Asia, 6.0% from Europe, 19.9% from North America, 26.5% from South America, and 25.2% from Australasia; 57.0% respondents worked in academic and 34.4% in private or mixed settings. Non-contrast ultrasound was most commonly used for screening and surveillance of HCC (90.7%), and multiphase computed tomography was used for diagnosis (96.0%). Extracellular contrast agents (69.5%) were the most commonly used MRI contrast agents and Lumason/SonoVue (31.1%) is the most commonly used contrast-enhanced ultrasound contrast agent. A majority (94.0%) of respondents use ancillary imaging features for assessment of liver lesions in at-risk patients. Usage of diagnostic imaging systems for HCC varied by region. RECIST or mRECIST criteria were most commonly used for assessing HCC treatment response (48.3%). Most respondents agreed that a standardized classification for the diagnosis of HCC is needed (68.9%) and that an atlas and lexicon would help improve inter-reader agreement (71.5%). Conclusion Practices and recommendations for imaging of HCC vary between geographical regions. Future efforts to develop a unified system should address regional differences and potential barriers for adoption of a standardized diagnostic system for HCC.